MULTI-PATIENT TOMOGRAPHY DEVICE

Abstract

MULTI-PATIENT TOMOGRAPHY DEVICE The present invention relates to a positron emission tomography device configured to generate tomographic images of at least one subject placed in an examination region. Abstract figure: Fig. 1

Description

Title of the invention: MULTI-PATIENT TOMOGRAPHY DEVICE FIELD OF INVENTION

[0001] The present invention relates to medical imaging devices, more particularly to preclinical imaging using positron emission tomography (PET). STATE OF THE ART

[0002] Conventional Positron Emission Tomography (PET) devices have long been used for medical imaging, but have some significant drawbacks that limit their accessibility.

[0003] In terms of cost, traditional PET scanners require considerable investment for both their acquisition and maintenance, which can be a financial barrier to their installation for many healthcare facilities. Furthermore, these scanners generally have long acquisition times, resulting in delays in the imaging process and limiting the number of patients that can be treated within a given period. These cost and time constraints can compromise the profitability and efficiency of medical imaging services, particularly in environments where the demand for PET scans is high.

[0004] This has the direct consequence that PET scans are either difficult for patients to access or subject to long waiting times, while demand continues to increase. Indeed, a growing demand for PET scans is observed in the evaluation and monitoring of radiotherapy, chemotherapy, or immunotherapy. Furthermore, the increasingly early detection of diseases such as cancers should lead to improved treatment outcomes and a growing demand for follow-up scans in the near future. For example, PET imaging after cancer screening can be expected for breast, lung, or prostate cancer. PET imaging is therefore no longer limited to tumor detection and monitoring its spread (as was previously the case), but is increasingly playing a crucial role in early diagnosis.

[0005] In order to keep up with this trend (and meet clinical needs) without further increasing healthcare costs, imaging services will need the capacity to scan more patients in a given period.

[0006] Consequently, there is a need for more efficient and economical PET devices, capable of meeting the growing needs for patient diagnosis and monitoring, allowing in particular an increase in patient throughput. SUMMARY

[0007] The present invention relates to a positron emission tomography apparatus configured to generate tomographic images of at least one subject placed in an examination region, the apparatus comprising: - a radiation detection device arranged to visualize the examination area and comprising an axial axis z running longitudinally through the center of the detection device, a radial axis x perpendicular to the axial axis z and a tangential axis y perpendicular to both the axial axis z and the radial axis x; - an examination platform extending along the axial axis z and inside the detection device, the examination platform comprising an examination area opposite the examination region and an installation area extending outside the examination region, the examination platform being configured to simultaneously accommodate at least two subjects, of which at least one subject is in the examination area; - an image generation device to generate 3D or 4D images from signals detected by the detection device in the examination region.

[0008] In one embodiment, the examination platform further comprises: - a fixed support; - a sliding plan placed on the fixed support and comprising at least two sections arranged side by side along an axis of the detection device and configured to accommodate each one subject, at least one first section being placed in the examination area and at least one second section being placed in the installation area or in the examination area; - a device for moving the sliding plane along an axis of the detection device configured to move at least one section of the installation area towards the examination area.

[0009] In one embodiment, the at least two sections are arranged side by side along the radial axis of the detection device, and the sliding plane movement device is configured to move the sliding plane along the axial axis of the detection device so that the examination platform is configured to simultaneously accommodate at least two subjects in the examination area. In one embodiment, the at least two sections are arranged side by side along the axial axis of the detection device, and the sliding plane movement device is configured to move the sliding plane along the axial axis of the detection device, so that the examination platform is configured to simultaneously accommodate one subject in the examination area and one subject in the setup area. In one embodiment, the at least two sections are arranged side by side along the radial axis of the device. The detection system includes a sliding plate movement device configured to move the sliding plate along the radial axis of the detection system, such that the examination tray is configured to simultaneously accommodate at least two subjects in the examination area or to simultaneously accommodate one subject in the examination area and one subject in the setup area. In one embodiment, the examination tray comprises at least two rows of at least two sections along an axis of the detection system, preferably along the radial or axial axis of the detection system. In one embodiment, the tomography system comprises at least two examination trays arranged side by side along the radial axis of the detection system.In one embodiment, the examination platform further comprises a fixed support including at least two sections arranged side by side along an axis of the detection device and configured to accommodate a subject each, with at least one section located in the examination area and at least one section located in the setup area or the examination area. In one embodiment, the detection device has a dimension along the axial axis of between 50 cm and 3 m. In another embodiment, the detection device has a dimension along the radial axis of between 50 cm and 10 m. In another embodiment, the detection device has a dimension along the tangential axis of between 20 cm and 1 m. DEFINITIONS

[0010] In the present invention, the terms below are defined as follows:

[0011] “Axial axis” (or longitudinal axis) refers to the main axis of a device (or A PET scanner is a PET scan that runs longitudinally through the center of the radiation detection device, preferably in a ring. This axis is parallel to the direction of movement of the scan platform. Detectors arranged along this axis capture positron emission data emitted by the radiopharmaceutical in the subject's body.

[0012] “Radial axis” (or transaxial) refers to an axis that is perpendicular to the axial axis and passes radially through the center of the radiation detection device. This axis defines the lateral or horizontal directions in the transverse plane. Transaxial images are generated using data captured along this axis, showing a cross-sectional view of the subject's body.

[0013] “Tangent axis” (or azimuth axis) refers to an axis that is perpendicular to both The axial axis and the radial axis. This axis defines the angular directions around the subject. The PET scanner can rotate around this axis to capture images from different angles, allowing for three-dimensional reconstruction of the data. DETAILED DESCRIPTION

[0014] The present invention relates to a positron emission tomography (PET) device configured to generate tomography images of at least one subject placed in an examination region.

[0015] The device comprises: - a radiation detection device arranged to visualize the examination area and comprising an axial axis longitudinally passing through the center of the detection device, a radial axis perpendicular to the axial axis and a tangential axis perpendicular to both the axial axis and the radial axis; - an examination platform extending along the axial axis and inside the detection device, the examination platform comprising an examination area opposite the examination region and an installation area extending outside the examination region, the examination platform being configured to simultaneously accommodate at least two subjects, of which at least one subject is in the examination area; - an image generation device to generate 3D or 4D images from signals detected by the detection device in the examination region.

[0016] The fundamental principle of a PET scanner (also commonly called a PET device) is based on the detection of gamma photons emitted during the annihilation of positrons in a subject's body. When a radiotracer, such as 18F-FDG (fluorodeoxyglucose labeled with fluorine-18), is injected into the body, it concentrates in areas of high metabolic activity, such as tumors or inflammatory tissues. The positrons emitted by the radiotracer interact with electrons in the surrounding tissues, resulting in their mutual annihilation. This annihilation produces two gamma photons emitted in opposite directions with a characteristic energy of 511 keV. The PET scanner uses detectors arranged around the subject to detect these gamma photons. These detectors are generally made of scintillation crystals that emit light when a gamma photon passes through them.Photons emitted by scintillation crystals are converted into electrical signals by photodetectors. When gamma photons are detected simultaneously by multiple detectors around a subject, this indicates positron emission that has occurred along the imaginary line connecting these detectors. By collecting information about positron emissions from different directions, the PET scanner can reconstruct a three-dimensional image of the radiotracer's distribution in the subject's body. This image allows physicians to identify areas of abnormal metabolic activity, such as cancerous tumors, infections, or inflammatory lesions, and to assess the response to treatment.

[0017] The examination region is defined as the spatial area in which the radiation emitted by the administered radiopharmaceutical (or radiotracer) can be detected by the detection device.

[0018] The aim of the invention is to make cancer screening by positron emission tomography (PET) technology compatible with a large target population (people aged 40 to 75) and / or to enable whole-body tumor molecular mapping (3-10 molecules characterizing lesions are studied for a subject).

[0019] Since the examination platform is configured to simultaneously accommodate at least two subjects, with at least one subject in the examination area, i.e., one subject in the examination area and one subject in the setup area, or two subjects in the examination area, preferably positioned side by side, the multi-patient PET scanner allows, in one case, for one subject to be set up while another subject is undergoing a PET scan and / or for simultaneous PET scans to be performed on two subjects. More specifically, the PET scanner described below optimizes resource utilization by efficiently sharing available time and equipment to perform parallel PET scans, while ensuring accurate and reliable data acquisition for each subject.

[0020] The PET device described here advantageously allows for the sharing of the detection area. Indeed, by allowing two (or more) subjects to be placed in the same examination area, each subject benefits from a larger detection area, contributing to an increase in detection sensitivity. The detection sensitivity will thus be four to six times greater than a conventional LAFOV PET scanner, sixty times greater than a SAFOV digital PET scanner, and 240 times greater than a SAFOV analog PET scanner. This notably allows for a corresponding reduction in the administered radiotracer dose, making the technique compatible with mass screening and potentially considered virtually non-irradiating.

[0021] The PET device described herein also advantageously allows for the sharing of detection time. Indeed, by allowing two (or more) subjects to be placed in the same examination area, the PET device enables the simultaneous acquisition of images for several subjects. For example, a 5-minute PET image acquisition for five subjects simultaneously positioned in the examination area is equivalent to acquiring one subject per minute if a conventional PET device were used (which is not possible because it would require increasing the administered dose by a factor of 5 for the same image quality).

[0022] The PET scanner described herein also advantageously allows for the sharing of setup time. Indeed, by allowing one subject to be simultaneously in the examination area and another in the setup area, the PET scanner enables ultra-fast setup of subjects. Thus, one (or more) subjects are removed and another (or Several) are installed during the acquisition time of another subject. The time the PET scanner spends detecting is advantageously and considerably improved. By comparison, it takes six minutes to install a conventional LAFOV PET scanner and three minutes for a CT scanner with five minutes of acquisition. With the PET scanner described here, it will take less than a minute to move a subject previously installed in the setup area into the examination zone and to remove the subject whose PET scan has been performed.

[0023] The invention therefore aims to accelerate the entire detection process, from the installation of the patient to the simultaneous detection of several subjects.

[0024] By way of comparison, a conventional SAFOV (small axial field of view) PET scanner can perform PET scans on 12 to 30 patients per day, while a standard LAFOV PET scanner can perform PET scans on 40 to 50 patients per day. The multi-patient PET scanner described here advantageously allows for a further increase in the daily patient throughput by sharing the detection area, detection time, and setup time. For example, it is conceivable that a medical imaging center equipped with a multi-patient PET scanner could perform between 300 and 3,000 PET scans per day, depending on the number of subjects that can be simultaneously positioned in the setup area and the scan area.

[0025] The ability to simultaneously image multiple subjects with a single PET scanner offers numerous significant advantages in the field of medical imaging. First, this approach allows for more efficient use of resources by maximizing scanner uptime and reducing patient wait times. By enabling the simultaneous examination of multiple patients, the imaging throughput is considerably increased, allowing for a faster response to patients' diagnostic and follow-up needs. Furthermore, this multi-patient PET scanner helps reduce operating costs by streamlining the use of equipment and associated human resources. In addition, simultaneous imaging of multiple patients can be particularly beneficial in busy hospital environments, where the demand for PET scans is high and resources are often limited.In summary, the ability to image multiple patients simultaneously with a single PET scanner offers advantages in terms of operational efficiency, reduced costs, and improved patient care. For example, the detection area per subject is approximately 35% of that of a conventional LAFOV PET scanner.

[0026] The present PET device can be used in a horizontal configuration in which subjects are lying on the examination platform, or in a vertical configuration in which subjects are standing against the examination platform.

[0027] In an alternative configuration, subjects are in a seated or semi-seated position. This configuration is not possible with traditional PET scanners because they require a scanner for attenuation correction. This position is psychologically more comfortable for the subject, as the supine position is associated psychologically with the illness. This configuration also allows for the rapid setup of several subjects simultaneously on a flat surface: in the case of three subjects, the middle subject must position themselves on the surface as a person would lie down in bed from the foot of the bed (which is not necessarily easy when space is limited and other subjects are already positioned to the side). It therefore reduces acquisition, setup, and removal time compared to the supine or standing positions.

[0028] The detection device is preferably of the long axial field of view (LAFOV) type. A LAFOV detection device advantageously allows imaging of a large portion of a subject's body, or even the entire body. An LAFOV detection device advantageously offers a combination of sensitivity, resolution, and functionality that makes it a valuable tool for the diagnosis, monitoring, and treatment of various medical conditions. Indeed, it allows for high spatial and temporal resolution, enabling the detection of even small abnormalities or changes in tissues. Thanks to its high sensitivity, the LAFOV detection device can detect diseases at an early stage, allowing for rapid and often more effective medical intervention. This also allows for the use of lower radiation doses, thus minimizing risks to subjects.

[0029] The detection device is preferably a monolithic device using scintillation crystals, such as, for example, BGO (bismuth germanium oxide), LYSO (lutetium-yttrium orthosilicate), or LSO (lutetium oxide orthosilicate), which convert the photons emitted by positrons into detectable electrical signals and possess depth of interaction (DOI) capabilities that allow a resolution of 1.2 mm to be maintained regardless of the angle of coincidence, unlike pixel-based detector technology. These crystals are often coupled to photodetectors, such as photomultiplier tubes (PMTs) or photodiode detectors, which amplify the light signals produced by the scintillation crystals and convert them into electrical signals for further analysis.These detectors are positioned around the subject to record positron emissions and reconstruct three-dimensional images of the distribution of radiotracers in the body. Preferably, the detection device incorporates silicon photomultiplier (SiPM) type detectors, a type of light-sensitive photodetector used to detect positrons. Photons emitted by scintillators. Advantageously, this type of photodetector exhibits high sensitivity and low background noise, allowing for better differentiation between useful and unwanted signals, thus contributing to improved image quality and greater detection accuracy. They can cover a wide dynamic range, meaning they can detect signals ranging from low to high intensity levels. These detectors also offer the advantage of fast response times, enabling rapid PET data acquisition. This reduces the time required for image acquisition. Finally, they are generally compact and energy-efficient, making them suitable for use in high-throughput PET scanners and facilitating the use of detectors with very fast times of flight, on the order of 50 ps to 10 ps, ​​enabling real-time imaging.

[0030] The detection device may include at least one internal wall (i.e. the wall closest to the subject in the examination area) and one external wall.

[0031] The radiation detection device may include a PET detection ring. In a specific configuration, the detection ring may have a circular, elliptical, oval, polygonal, square, rectangular, or D-shaped geometry. In the case of a detection ring, the ring comprises an inner wall and an outer wall, the diameter defined by the inner wall being between 20 cm and 10 m, preferably between 30 cm and 5 m, and more preferably between 35 cm and 5 m. This advantageous geometry, close to the patient's body, increases the number of photon pairs detected due to the increased angles of incidence. Advantageously, the use of a PET detection ring also allows for three-dimensional detection, i.e., the capture of signals emitted in all directions around the subject, thus enabling three-dimensional image reconstruction.This provides a comprehensive view of the radioactive tracer's distribution within the body, allowing for a more precise assessment of metabolic activity. It also enables the collection of more data in a single acquisition, resulting in shorter examination times and more efficient use of scan time. The detection ring's geometry allows for precise image reconstruction, leading to more reliable and accurate results in terms of lesion localization and metabolic activity quantification. Finally, with a detection ring, subjects can be positioned in various ways while still ensuring complete image acquisition. This allows for better adaptation to the subject's specific needs or certain examination requirements.

[0032] According to an alternative illustrated in [Fig. 5], the radiation detection device may comprise two parallel plates arranged on either side of the examination platform and extending along the axial axis. In the case of two plates The parallel detection device comprises two inner walls, i.e., the faces of the two plates opposite each other, and two outer walls, i.e., the faces of the two plates opposite each other. The distance between two inner walls is between 20 cm and 1 m, preferably between 30 cm and 75 cm, and more preferably between 35 cm and 50 cm. Advantageously, the use of two parallel plates allows for high spatial resolution, leading to better visualization of small structures and more precise localization of metabolic activity within the body. Finally, this configuration allows for rapid patient setup with a single entry and exit point.

[0033] The detection device may have an axial dimension (length) of between 50 cm and 3 m, preferably between 60 cm and 250 cm, and more preferably between 70 cm and 220 cm. This dimension advantageously allows the detection device to have a length along the axial axis sufficient to generate tomographic images of a part of a subject's body or of the entire body of a subject.

[0034] The detection device may have a dimension along the radial axis (width) of between 50 cm and 10 m, preferably between 60 cm and 7.5 m, more preferably between 70 cm and 5 m. This dimension advantageously allows the detection device to be very wide along the radial axis, enabling the examination platform to accommodate several subjects in the examination area in order to perform simultaneous PET examinations.

[0035] The detection device may have a dimension along the tangential axis (thickness) of between 20 cm and 1 m, preferably between 30 cm and 75 cm, and more preferably between 35 cm and 50 cm. This dimension along the tangential axis advantageously allows the detection device to be very close to the subject. This advantageous geometry, close to the patient's body, increases the number of photon pairs detected due to the increased angles of incidence. The dimension ranges above allow for compatibility with most templates down to 20 cm, preferably 35-40 cm to accommodate the thinnest templates.

[0036] The detection device may have a non-homogeneous dimension along the tangential axis, i.e., there may be a thickness gradient along the radial axis, with the thickness at one radial end being less than at the other radial end. Advantageously, this allows for the accommodation of different templates along the radial axis while maintaining an optimal subject-detector distance. This geometry is best suited to the morphology of subjects with personalized acolinearity. In comparison, and to a disadvantage, a conventional PET scanner, i.e., one that can only accommodate a single patient, must have a geometry that allows it to adapt to the most corpulent subjects. at the expense of geometry and therefore requiring a large number of detectors (suboptimal fixed linearity).

[0037] The detection device may include an upper module intended to be placed above the examination platform at the level of the examination area, a lower module intended to be placed below the examination platform at the level of the examination area, and at least one lateral module, preferably two lateral modules, intended to be placed on either side of the examination platform along the radial axis. The upper and lower modules are assembled with the lateral modules to form the detection device. The lateral modules may be symmetrical (promoting versatility) or asymmetrical (geometry adapted to the morphology of the subjects with personalized acollinearity). Preferably, the lateral modules are asymmetrical.

[0038] In a configuration specific to a side module, the detection device therefore includes a lateral opening allowing a subject to pass into the examination area. The side modules may be fixed or removable. At least one side module may be a door associated with a actuator allowing the detection device to be opened and closed.

[0039] As illustrated in Figures 5-6, the radiation detection device may include at least one opening located at one end of the examination platform along the radial axis of the detection device, the opening being configured to allow a subject to position themselves in the setup area and / or the examination area. In the case of a vertically arranged PET scanner, this opening (or these openings) allows the subject to easily position themselves in the examination area.

[0040] The examination area and / or the installation area may have a dimension along the axial axis between 50 cm and 3 m, preferably between 60 cm and 250 cm, more preferably between 70 cm and 220 cm.

[0041] The examination area and / or the installation area may have a dimension along the radial axis between 50 cm and 10 m, preferably between 60 cm and 7.5 m, more preferably between 70 cm and 5 m.

[0042] The examination area may have a dimension along the tangential axis of between 20 cm and 1 m, preferably between 30 cm and 75 cm, and more preferably between 35 cm and 50 cm. This dimension corresponds in particular to the distance between the examination platform and the detection device along the tangential axis. Advantageously, the subject is thus positioned directly at the required height for optimal detection by the detection device, also reducing acolinearity.

[0043] The examination platform may further include: - a fixed support; - a sliding panel mounted on the fixed support and comprising at least two sections arranged side by side along an axis of the detection device and configured to accommodate a subject each, with at least one first section being placed in the examination area and at least one second section being placed in the installation area or in the examination area; - a device for moving the sliding plane along an axis of the detection device configured to move at least one section of the installation area towards the examination area.

[0044] This configuration of the examination platform advantageously allows two subjects to be accommodated simultaneously in the examination area or one subject in the examination area and one subject in the installation area.

[0045] In the case of the simultaneous reception of two subjects in the examination area, it is advantageously possible to generate, simultaneously, tomography images of two subjects placed in an examination region.

[0046] In the case of simultaneous placement of a subject in the examination area and a subject in the setup area, it is advantageous to place one subject in the setup area and perform the PET scan of another subject simultaneously. Here, one subject can be positioned while the previous one is being examined. When the scan of the subject positioned in the examination area is complete, the sliding platform is moved so that the subject previously positioned in the setup area is moved into the examination area for examination.

[0047] This configuration of the examination platform therefore allows a considerable time saving for the operator, and a time saving for a patient since, the throughput of patients in a given period being increased, the waiting time to have an imaging appointment will be shorter.

[0048] The fixed support may include a platform supported by four legs. For example, the fixed support is a table.

[0049] The sliding plane can be a carbon plate. Advantageously, carbon exhibits low photon attenuation while being rigid, and a carbon sliding plane will be lightweight and therefore easier to move.

[0050] The sliding panel may include separating elements to isolate the sections (or reception sections). This isolation may advantageously be physical, in order to preserve the privacy of each subject installed in a section of the panel. It may also advantageously allow for the isolation of signals detected in each section, resulting in a lower signal-to-noise ratio due to the suppression of artifacts originating from another subject installed in a neighboring section.

[0051] A section may have a dimension along the axial axis of between 50 cm and 3 m, preferably between 60 cm and 250 cm, more preferably between 70 cm and 220 cm.

[0052] A section may have a dimension along the radial axis between 40 cm and 70 cm.

[0053] The device for moving the sliding plane can be a rail.

[0054] As illustrated in [Fig. 3], the at least two sections can be arranged side by side along the radial axis of the detection device, and the sliding plane movement device is configured to move the sliding plane along the axial axis of the detection device so that the examination platform is configured to simultaneously accommodate at least two subjects in the examination area. Side-by-side sections along the radial axis of the detection device are defined as two adjacent sections along this radial axis, i.e., sharing their longest side along the axial axis. Such sections are hereinafter referred to as "radial sections." Ideally, this configuration is used in the case of a horizontal floor examination platform, in which two subjects can each lie in a section, so as to be simultaneously positioned in the examination area.This configuration advantageously allows for the simultaneous generation of tomography images of two subjects positioned in the same examination area. Such a configuration therefore results in considerable time savings for the operator, since the subjects can be imaged two at a time, and time savings for the patient because, with the number of examinations doubled, the waiting time for an imaging appointment will be shorter.

[0055] As illustrated in Figures 1-3, the at least two sections can be arranged side by side along the axial axis of the detection device, and the sliding plane movement device is configured to move the sliding plane along the axial axis of the detection device, so that the examination platform is configured to simultaneously accommodate one subject in the examination area and one subject in the setup area. Side-by-side sections along the axial axis of the detection device are defined as two adjacent sections along this axial axis, i.e., sharing their side along the radial axis. Such sections are hereinafter referred to as "axial sections." Ideally, this configuration is used in the case of a horizontal floor examination platform, in which two subjects can each lie in a section, so as to be placed simultaneously on the examination platform, one subject being in the examination area and one subject being in the setup area.This configuration advantageously allows for the simultaneous placement of one subject in the installation area and the PET scan of another subject. This configuration therefore results in considerable time savings for the operator. Indeed, with a conventional PET scanner, the installation of a subject requires that the previous subject has vacated the space. Here, a subject can be installed while the previous one is being examined. The removal and subsequent installation of a subject takes approximately 5-10 minutes, representing a significant time saving for the operator. Once the scan of the subject in the examination area is complete, the sliding platform is moved so that the subject previously in the installation area is transferred to the examination area for further examination. This also represents a time saving for the patient since it will be possible, with this configuration, to increase the number of examinations per day, so the waiting time for an imaging appointment will be shorter.

[0056] The at least two sections can be arranged side by side along the radial axis of the detection device, and the sliding plane movement device is configured to move the sliding plane along the radial axis of the detection device, so that the examination platform is configured to simultaneously accommodate at least two subjects in the examination area or to simultaneously accommodate one subject in the examination area and one subject in the setup area. Side-by-side sections along the radial axis of the detection device are defined as two adjacent sections along this radial axis, i.e., sharing their side along the axial axis. Such sections are hereinafter referred to as "radial sections".Ideally, this configuration is used with an examination platform perpendicular to the floor, allowing two subjects to stand in separate sections so they can be positioned simultaneously on the platform. One subject can be in the examination area and the other in the setup area, or both subjects can be in the examination area simultaneously. This configuration allows for the simultaneous setup of one subject in the setup area and the PET scan of another subject. This results in considerable time savings for the operator. Indeed, with a conventional PET scanner, positioning a new subject requires the previous subject to have vacated the space. Here, a subject can be positioned while the previous one is being examined. Since positioning a new subject takes approximately 5-10 minutes, this translates into significant time savings for the operator.When the scan of the subject positioned in the examination area is complete, the sliding platform moves so that the subject previously in the setup area is moved to the examination area for scanning. This also saves time for the patient, as this configuration allows for an increased number of examinations per day, thus shortening the wait for an imaging appointment. Alternatively, this configuration advantageously allows for the simultaneous generation of tomography images of two subjects positioned in the same examination area. Such a configuration therefore offers considerable time savings for the operator, since the subjects can be imaged two at a time, and time savings for the patient, since the number of examinations is doubled, resulting in a shorter wait for an imaging appointment.

[0057] The examination platform may comprise at least two rows of at least two sections along an axis of the detection device, preferably along the radial or axial axis of the detection device. Advantageously, this configuration allows for the simultaneous installation of several subjects and / or the performance of simultaneous PET scans on several subjects.

[0058] Alternatively, the examination platform may include a fixed support comprising at least two sections arranged side by side along an axis of the detection device and configured to accommodate each one subject, at least a first section being arranged in the examination area and at least a second section being arranged in the installation area or in the examination area.

[0059] The examination tray can be confused with the internal wall of the detection device.

[0060] In this configuration, the examination platform does not include a sliding plane, the subjects moving themselves into the examination area.

[0061] As illustrated in Figures 4-6, the at least two sections can be arranged side by side along the radial axis of the detection device, and the sliding plane displacement device is configured to move the sliding plane along the radial axis of the detection device, so that the examination platform is configured to simultaneously accommodate at least two subjects in the examination area or to simultaneously accommodate one subject in the examination area and one subject in the setup area. Side-by-side sections along the radial axis of the detection device are defined as two adjacent sections along this radial axis, i.e., sharing their side along the axial axis. Such sections are hereinafter referred to as "radial sections".Ideally, this configuration is used with an examination platform perpendicular to the floor, allowing two subjects to stand in separate sections so they can be positioned simultaneously on the platform. One subject can be in the examination area and the other in the setup area, or both subjects can be in the examination area simultaneously. This configuration advantageously allows for one subject to be positioned in the setup area while another subject undergoes a PET scan simultaneously. Alternatively, this configuration also allows for the simultaneous generation of tomography images of two subjects positioned in the same examination region. Such a configuration therefore offers considerable time savings for the operator, as the subjects can be imaged two at a time.This also represents a time saving for the patient since, with this configuration, it will be possible to increase the number of examinations per day, thus shortening the waiting time for an imaging appointment.

[0062] The examination platform is configured to accommodate at least two subjects, for example between 2 and 20 subjects, preferably between 2 and 12 subjects.

[0063] As illustrated in [Fig. 3], the PET scanner may comprise at least two examination platforms arranged side by side along the radial axis of the detection device. This advantageously allows the number of radial and / or axial sections to be adjusted according to needs or the available space in the PET scanner's installation area. It is therefore possible to increase the number of sections available in the installation area and / or in examination area. This configuration allows for the simultaneous installation of multiple subjects and / or the performance of simultaneous PET scans on multiple subjects. This configuration also allows for significant modularity of the PET scanner according to needs, and the possibility of future upgrades (increasing or decreasing the number of platforms over time).

[0064] Alternatively, as illustrated in Figures 2 and 4-6, the PET scanner may comprise a single examination platform with at least two subject reception sections. This "monoblock" or "single-platform" configuration advantageously allows for the simultaneous installation of several subjects and / or the performance of simultaneous PET scans on multiple subjects.

[0065] The examination platform may include a jack configured to elevate a subject. This is particularly advantageous in the vertical configuration of the PET scanner because it becomes possible to elevate one or more subjects depending on the area of ​​the body of interest, for example, for leg imaging. This jack can be combined with a seat and / or a headrest, allowing each subject to be centered with respect to the detection device.

[0066] The image generation device is an image generation device configured to collect the signal by photoelectric effect, Compton effect or other effect known in the field of PET imaging.

[0067] The image generation device is configured to generate three-dimensional (3D), four-dimensional (4D), five-dimensional (5D) or six-dimensional (6D) images from signals detected by the detection device in the examination region.

[0068] In medical imaging, a 4D image is a three-dimensional (3D) representation that evolves over time (fourth dimension). Unlike a static image, which captures a snapshot, a 4D image allows visualization of a phenomenon or process in motion or evolving over time. In Positron Emission Tomography (PET), for example, a 4D image can be used to observe the distribution and elimination of a radiotracer in the body over time after its injection. This capability makes it possible to dynamically study the kinetics of a radiotracer in different organs or tissues, thus providing valuable information on metabolic processes, tissue perfusion, or organ function.

[0069] In medical imaging, a 5D image is a multidimensional representation that includes not only the three spatial dimensions (length, width, and depth) but also a temporal dimension (fourth dimension) and another additional dimension. This additional dimension may vary depending on the context and the type of imaging, but it may include parameters such as heart rate, Variations in contrast, or other physiological or functional data. 5D image acquisition can provide a more complete and dynamic visualization of biological processes, anatomical changes, and responses to treatments.

[0070] In medical imaging, a 6D image comprises six dimensions, generally the three spatial dimensions (length, width, depth) as well as three additional dimensions. These additional dimensions can represent temporal variations, functional data, physiological data, or other specific characteristics of the observed phenomenon. A 6D image thus integrates spatial, temporal, and functional information to provide an even more complete and detailed representation of an anatomical structure, a biological process, or a physiological function.

[0071] The image generation device can be configured to simultaneously generate tomography images of at least two subjects placed in an examination region.

[0072] The image generation device may further include: - an image generation means to generate images from signals detected by the detection ring in the examination region; - a means of generating tomographic images configured to reconstruct a series of tomoscintigraphic images, so as to generate tomographic images of subjects placed in the examination region.

[0073] The present invention also relates to a method for generating tomography images of at least one subject placed in an examination area, comprising - supply of a positron emission tomography device according to the invention; - installation of at least one subject in the examination area of ​​the examination platform; - generation of tomography images of at least one subject placed in the examination region.

[0074] In this method, two subjects can be simultaneously placed in the PET device: a first subject in the examination area and a second subject in the installation area, or two subjects in the examination area.

[0075] Advantageously, said method makes it possible to optimize the use of resources by efficiently sharing the time and equipment available to perform parallel PET examinations, while ensuring accurate and reliable data acquisition for each subject.

[0076] In the case of a first subject in the examination area and a second subject in the installation area, the method may simultaneously include the generation step of tomography images of the first subject, the installation of the second subject in the installation area.

[0077] In the case of a first subject in the examination area and a second subject in the installation area, the method may include, following the step of generating tomography images of the first subject, moving the second subject into the examination area and then generating tomography images of the second subject.

[0078] The present invention also relates to a method for simultaneously generating tomography images of at least two subjects placed in an examination area, comprising: - supply of a positron emission tomography device according to the invention; - simultaneous generation of tomography images of subjects placed in the examination area.

[0079] Advantageously, said method makes it possible to optimize the use of resources by efficiently sharing the time and equipment available to perform parallel PET examinations, while ensuring accurate and reliable data acquisition for each subject. BRIEF DESCRIPTION OF THE FIGURES

[0080] [Fig.1] illustrates an examination platform 12 according to an embodiment of the invention.

[0081] [Fig.2] illustrates a PET device 1 according to a first embodiment of the invention.

[0082] [Fig.3] illustrates a PET device 1 according to a second embodiment of the invention.

[0083] [Fig.4] illustrates a PET device 1 according to a third embodiment of the invention.

[0084] [Fig.5] illustrates a PET device 1 according to a fourth embodiment of the invention.

[0085] [Fig.6] illustrates a PET device 1 according to a fifth embodiment of the invention.

[0086] [Fig.7] illustrates a PET device 1 according to a sixth embodiment of the invention. ILLUSTRATIVE METHODS OF IMPLEMENTING THE INVENTION

[0087] In an embodiment illustrated in [Fig. 1], the examination platform 12 comprises: - an examination area 121 opposite the examination region; - an installation zone 122 extending outside the examination area; - a fixed support 123; - a sliding plan 124 arranged on the fixed support and comprising two sections 125 arranged side by side along the axial axis z of the detection device and configured to accommodate each one subject, a first section 125 being arranged in the examination area 121 and a second section 125 being arranged in the installation area 122.

[0088] In a first embodiment illustrated in [Fig.2], the PET device 1 comprises: - a radiation detection device 11, in the form of a ring, arranged to visualize the examination region and comprising an axial axis z longitudinally passing through the center of the detection device 11, a radial axis x perpendicular to the axial axis z and a tangential axis y perpendicular to both the axial axis z and the radial axis x; - an examination platform 12 extending along the axial axis z and inside the detection device 11, the examination platform 12 comprising: • an examination area 121 opposite the examination region; • an installation area 122 extending outside the examination area; • a fixed support 123; • a sliding plan 124 arranged on the fixed support and comprising two sections 125 arranged side by side along the axial axis z of the detection device and configured to accommodate each one subject, a first section 125 being arranged in the examination area 121 and a second section 125 being arranged in the installation area 122.

[0089] These two embodiments are particularly advantageous because they allow for the simultaneous placement of a subject in the examination area 121 and a subject in the loading area 122. It is then possible to place a subject in the loading area 121 and to perform a PET scan on another subject simultaneously. Here, a subject can be placed while the previous one is being examined. When the scan of the subject placed in the examination area 121 has been completed, the sliding platform 124 is moved so that the subject previously placed in the loading area 122 is moved into the examination area 121 for examination. This therefore results in considerable time savings for both the operator and the patients.

[0090] In a second embodiment illustrated in [Fig. 3], the PET device 1 comprises: - a radiation detection device 11, in the form of a ring, arranged to visualize the examination region and comprising an axial axis z passing longitudinally through the center of the detection device 11, an axis radial x perpendicular to the axial axis z and a tangential axis y perpendicular to both the axial axis z and the radial axis x; - six examination platforms 12 extending along the axial axis z and inside the detection device 11, each examination platform 12 comprising: • an examination area 121 opposite the examination region; • an installation area 122 extending outside the examination area; • a fixed support 123; • a sliding plan 124 arranged on the fixed support and comprising two sections 125 arranged side by side along the axial axis z of the detection device and configured to accommodate each one subject, a first section 125 being arranged in the examination area 121 and a second section 125 being arranged in the installation area 122.

[0091] The six examination platforms 12 arranged side by side along the radial axis x of the detection device 11. The PET device 1 therefore comprises six radial sections 125 able to accommodate a total of six patients in the installation area 122 and six radial sections 125 able to accommodate a total of six patients in the examination area 122.

[0092] This embodiment is particularly advantageous because it allows six subjects to be simultaneously accommodated in the examination area 121 and six subjects in the setup area 122. It is therefore possible to position six subjects in the setup area 121 and to perform PET scans on six other subjects simultaneously. This results in considerable time savings for both the operator and the patients, since the scanning time and the setup time are combined. Indeed, tomographic images can be generated simultaneously for six patients during an acquisition time equal to that of a single PET scan, and six patients can be positioned while six patients are being examined.For comparison, a conventional LAFOV PET scanner requires six minutes of setup and three minutes of CT scanning for five minutes of acquisition per patient, i.e., 2 hours and 48 minutes for 12 patients, whereas with the PET 1 device using this method, it will take less than 20 minutes to perform the scans of the 12 patients.

[0093] In a third embodiment illustrated in [Fig. 4], the PET device 1, in a vertical configuration, comprises: - a radiation detection device 11, arranged to visualize the examination area and comprising an axial axis z passing longitudinally through the center of the detection device 11, a radial axis x perpendicular to the axial axis z and a tangential axis y perpendicular to both the axial axis z and the radial axis x, the detection device 11 comprising an upper module 111, a lower module 112 and two lateral modules 113 which together form the detection device 11; - an examination platform 12 extending along the axial axis z and inside the detection device 11, the examination platform 12 comprising: • an examination area 121 opposite the examination region; • a fixed support 123 comprising five sections 125 arranged side by side side by side along the radial x axis and configured to accommodate each one subject, sections 125 being arranged in examination area 121.

[0094] In this case, the examination platform is confused with the internal wall of the lower module 112.

[0095] In a fourth embodiment illustrated in [Fig. 5], the PET device 1, in a vertical configuration, comprises: - a radiation detection device 11, arranged to visualize the examination region and comprising an axial axis z running longitudinally through the center of the detection device 11, a radial axis x perpendicular to the axial axis z and a tangential axis y perpendicular to both the axial axis z and the radial axis x, the detection device 11 comprising two parallel detection plates 114; - an examination platform 12 extending along the axial axis z and inside the detection device 11, the examination platform 12 comprising: • an examination area 121 opposite the examination region; • a fixed support 123 comprising five sections 125 arranged side by side side by side along the radial x axis and configured to accommodate each one subject, sections 125 being arranged in examination area 121.

[0096] In this case, the examination platform is confused with the inner wall of a detection plate 114.

[0097] In a fifth embodiment illustrated in [Fig. 6], the PET device 1, in a vertical configuration, comprises: - a radiation detection device 11, arranged to visualize the examination region and comprising an axial axis z running longitudinally through the center of the detection device 11, a radial axis x perpendicular to the axial axis z and a tangential axis y perpendicular to both the axial axis z and the radial axis x, the detection device 11 comprising an upper module 111, a lower module 112 and a lateral module 113 which together form the detection device 11; - an examination platform 12 extending along the axial axis z and inside the detection device 11, the examination platform 12 comprising: • an examination area 121 opposite the examination region; • a fixed support 123 comprising five sections 125 arranged side by side along the radial x axis and configured to accommodate each one subject, the sections 125 being arranged in the examination area 121.

[0098] In this case, the examination platform is confused with the internal wall of the lower module 112.

[0099] In a sixth embodiment illustrated in [Fig.7], the PET device 1, in a vertical configuration, comprises: - a radiation detection device 11, arranged to visualize the examination region and comprising an axial axis z running longitudinally through the center of the detection device 11, a radial axis x perpendicular to the axial axis z and a tangential axis y perpendicular to both the axial axis z and the radial axis x, the detection device 11 comprising an upper module 111, a lower module 112 and a lateral module 113 which together form the detection device 11; - two examination platforms 12 extending along the axial axis z and inside the detection device 11, the examination platform 12, each comprising: • an examination area 121 opposite the examination region; • a fixed vertical support 123 comprising six sections 125 (delimited by dotted lines in the figure) arranged side by side along the radial axis x and configured to accommodate each one subject, the sections 125 being arranged in the examination area 121; • a horizontal sliding plane 124 configured to move along the tangential y axis; • each section 125 being equipped with a device for maintaining the patient in a semi-sitting position 127 equipped with a jack 128, a head support device 129 and a wrist support device (not shown).

[0100] In this particular embodiment, the detection device therefore includes a lateral opening allowing for the rapid passage and positioning of patients. The patient restraint devices (127, 128, 129) allow for precise positioning of patients relative to the radiation detection device 11 (centered, at the correct height) and ensure their immobility throughout the scan.

[0101] These vertically configured embodiments are particularly advantageous because they allow for the simultaneous acquisition and generation of tomographic images for five subjects. This results in considerable time savings for both the operator and the patients, as the scanning time is shared. NUMERICAL REFERENCES

[0102] 1 - Positron emission tomography apparatus / / 11- Detection device Radiation / / 111- Upper Module / / 112- Lower Module / / 113- Lateral Module / / 114 - Detection Plates / / Z- Axial Axis / / X- Radial Axis / / Y- Tangential Axis / / 12 - Examination Platform / / 121 - Examination Area / / 122 - Installation Area / / 123 - Fixed Support / / 124 - Sliding Plane / / 125 - Section / / 126 - Sliding Plane Displacement Device / / 127 - Patient Holding Device in Semi-Sitting Position / / 128 - Jack / / 129 - Head Holding Device

Claims

1.

2. Demands A positron emission tomography (PET) scanner (1) configured to generate tomographic images of at least one subject placed in an examination region, the scanner (1) comprising: - a radiation detection device (11) arranged to visualize the examination region and comprising an axial axis (z) longitudinally passing through the center of the detection device (11), a radial axis (x) perpendicular to the axial axis (z) and a tangential axis (y) perpendicular to both the axial axis (z) and the radial axis (x); - an examination platform (12) extending along the axial axis (z) and inside the detection device (11), the examination platform (12) comprising an examination area (121) opposite the examination region and an installation area (122) extending outside the examination region, the examination platform (12) being configured to simultaneously accommodate at least two subjects, of which at least one subject is in the examination area (121); - an image generation device to generate 3D or 4D images from signals detected by the detection device (11) in the examination region. Positron emission tomography apparatus (1) according to claim 1, wherein the examination platform (12) further comprises: - a fixed support (123); - a sliding plan (124) arranged on the fixed support (123) and comprising at least two sections (125) arranged side by side along an axis of the detection device (x, y, z) and configured to accommodate each one subject, at least a first section (125) being arranged in the examination area (121) and at least a second section (125) being arranged in the installation area (122) or in the examination area (121); - a device for moving the sliding plane (124) along an axis of the detection device (x, y, z) configured to move at least one section (125) from the installation area (122) to the examination area (121).

3. Positron emission tomography apparatus (1) according to claim 1 or 2, wherein the at least two sections (125) are arranged side by side along the radial axis of the detection device (x), and the sliding plane displacement device (124) is configured to move the sliding plane (124) along the axial axis of the detection device (z) so that the examination tray (12) is configured to simultaneously accommodate at least two subjects in the examination region.

4. Positron emission tomography apparatus (1) according to any one of claims 1 to 3, wherein the at least two sections (125) are arranged side by side along the axial axis of the detection device (z), and the sliding plane displacement device (124) is configured to move the sliding plane (124) along the axial axis of the detection device (z), so that the examination tray (12) is configured to simultaneously accommodate a subject in the examination region and a subject in the setup area (122).

5. Positron emission tomography apparatus (1) according to claim 1 or 2, wherein the at least two sections (125) are arranged side by side along the radial axis of the detection device (x), and the sliding plane displacement device (124) is configured to move the sliding plane (124) along the radial axis of the detection device (x), so that the examination tray (12) is configured to simultaneously accommodate at least two subjects in the examination region or simultaneously accommodate one subject in the examination region and one subject in the setup area (122).

6. Positron emission tomography apparatus (1) according to any one of claims 1 to 5, wherein the examination platform (12) comprises at least two rows of at least two sections (125) along an axis of the detection device (x, y, z), preferably along the radial axis (x) or the axial axis (z) of the detection device (11).

7. Positron emission tomography apparatus (1) according to any one of claims 1 to 6, comprising at least two examination platforms (12) arranged side by side along the radial axis of the detection device (x).

8. Positron emission tomography apparatus (1) according to claim 1, wherein the examination platform (12) further comprises a fixed support (123) comprising at least two sections (125) arranged side by side along an axis of the detection device (x, y, z) and configured to accommodate each one subject, at least a first section (125) being disposed in the examination area (121) and at least a second section (125) being disposed in the installation area (122) or in the examination area (121).

9. Positron emission tomography apparatus (1) according to any one of claims 1 to 8, configured to accommodate a subject in a supine or standing position.

10. Positron emission tomography apparatus (1) according to any one of claims 1 to 8, configured to accommodate a subject in a seated or semi-seated position.

11. Positron emission tomography apparatus (1) according to any one of claims 1 to 10, wherein the detection device (11) has a dimension along the axial axis (z) of between 50 cm and 3 m.

12. Positron emission tomography apparatus (1) according to any one of claims 1 to 11, wherein the detection device (11) has a dimension along the radial axis (x) between 50 cm and 10 m.

13. Positron emission tomography apparatus (1) according to any one of claims 1 to 12, wherein the detection device (11) has a dimension along the tangential axis (y) of between 20 cm and 1 m.