External composition for skin

Abstract

To provide an external composition for skin with suppressed coloration.SOLUTION: An external composition for skin is prepared that contains (A) nicotinamide of 3 mass% or more, (B) two or more selected from the group consisting of hyaluronic acid, a derivative thereof, a salt thereof, and a heparin analog; and (C) an amphiphilic compound.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for external use on the skin. More specifically, the present invention relates to a composition for external use on the skin containing nicotinamide. The present invention relates to a composition for external use on the skin. [Background technology]

[0002] Nicotinamide is a vitamin that has been used extensively in the skin care field to date. It is an ingredient that is used to promote circulation, as an anti-inflammatory, and to promote ceramide synthesis, and is also effective in improving beauty. It is also known to have whitening, anti-wrinkle and anti-aging effects.

[0003] For example, Patent Document 1 discloses riboflavin, pyridoxine hydrochloride, nicotinamide and A skin whitening agent containing one or more active ingredients selected from the group consisting of calcium anthrate and calcium phosphate has been proposed. It is being done.

[0004] In addition, Patent Document 2 discloses a method for producing a nicotinamide-based amine compound having 2 to 28 carbon atoms. It is characterized in that it contains one or more compounds selected from the group consisting of α-hydroxycarboxylic acid compounds. Cosmetics for preventing skin aging have been proposed. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2004-217629 A [Patent Document 2] Japanese Patent Application Publication No. 10-130135 Summary of the Invention [Problem to be solved by the invention]

[0006] In order to effectively utilize the various benefits of nicotinamide, nicotinamide is used at high concentrations. However, the present inventors have developed a formulation containing 3% by mass of component (A). The above nicotinamide and component (B) hyaluronic acid, its derivatives, and their salts, as well as and coloring occurs when the substance coexists with two or more substances selected from the group consisting of heparin-like substances. This led to the discovery of a new problem.

[0007] Therefore, the present invention contains a high concentration of nicotinamide, 3% by mass or more, as component (A). The present invention aims to provide a composition for external use on the skin that is inhibited from discoloring even when exposed to heat or moisture. [Means for solving the problem]

[0008] As a result of intensive research by the present inventors to solve the above problems, (A) 3% by mass or more of nicotinamide; and (B) The group consisting of hyaluronic acid, its derivatives, their salts, and heparinoids. In addition to two or more selected from the above, (C) an amphiphilic compound is added to the composition, thereby providing coloring. The present invention has been completed based on the discovery that the above-mentioned problems can be suppressed.

[0009] That is, the present invention provides the following compositions for external use on the skin. Section 1. (A) 3% by mass or more of nicotinamide; (B) The group consisting of hyaluronic acid, its derivatives, their salts, and heparinoids. Two or more selected from the following: (C) A composition for topical application to the skin containing an amphiphilic compound. Section 2. Item 2. The composition according to item 1, wherein the content of the component (A) is 3 to 20% by mass. Section 3. The component (C) is a compound represented by the following general formula (I), 2-methacryloyloxyethyl ether Poly(ethylphosphorylcholine / butyl methacrylate) copolymer, (eicosanedioic acid / tetradecane Decaglyceryl diacid, bisethoxydiglycol cyclohexanedicarboxylate, amber diethylhexyl succinate, diethoxyethyl succinate, and alkanedioic acid having 5 to 10 carbon atoms Item 3. The composition according to item 1 or 2, wherein the composition is one or more selected from the group consisting of alcohols.

[0010] [ka] (In the formula, Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms, which has n hydroxy groups. means the residue obtained by removing; AO means an oxyalkylene group having 3 to 4 carbon atoms; EO means an oxyethylene group; BO means an oxyalkylene group having 4 carbon atoms; n is 1 to 9; a, b, and c each represent the average number of moles of AO, EO, and BO added, and are independently 0 to The number is 200. However, a, b, and c cannot all be 0. Also, when n is 2 or more, Each of the multiple a's, b's, and c's may be the same or different. When Z is a hydrogen atom, n is 1. do. In addition, AO and EO may be added randomly or in the form of a block. Section 4. The component (C) is a compound represented by the following general formula (II), 2-methacryloyloxy Ethyl phosphorylcholine-butyl methacrylate copolymer, (eicosanedioic acid / tetradeca Decaglyceryl cyclohexanedicarboxylate, bisethoxydiglycol cyclohexanedicarboxylate, Diethylhexyl succinate, diethoxyethyl succinate, and dialkyl alkane having 5 to 10 carbon atoms. 3. The composition according to claim 1, wherein the organic solvent is one or more selected from the group consisting of phenols.

[0011] [ka] (In the formula, Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms, which has n hydroxy groups. means the residue obtained by removing; AO means an oxyalkylene group having 3 to 4 carbon atoms; EO means an oxyethylene group; n is 1 to 9; a and b each represent the average number of moles of AO and EO added, and are independently 0 to 200. However, a and b cannot all be 0. Also, when n is 2 or more, multiple a and b They may be the same or different. When Z is a hydrogen atom, n is 1. In addition, AO and EO may be added randomly or in the form of a block. Section 5. In the general formulas (I) and (II), Z is a hydrogen atom or a carbon number 4-24 alkyl monoalcohol, glycerin, trimethylolpropane, erythritol ethanol, pentaerythritol, alkyl glucoside, diglycerin, xylitol, dipeptide pentaerythritol, sorbitol, inositol, sucrose, trehalose, or Item 3, which is a residue obtained by removing n hydroxyl groups from maltitol Or the composition described in 4. Section 6. In the general formulas (I) and (II), Z is a hydrogen atom or a carbon number 4-24 alkyl monoalcohol, glycerin, or diglycerin to n-hydroxyl group Item 5. The composition according to item 3 or 4, wherein the residue is obtained by removing an oxy group. Effect of the Invention

[0012] According to the present invention, a nicotinic acid amide having a high concentration of 3% by mass or more as component (A) and a component (B ) A substance selected from the group consisting of hyaluronic acid, its derivatives, their salts, and heparinoids. The present invention provides a composition for external use on the skin that is inhibited from discoloring even when two or more selected from the group consisting of phenylalanine and phenylalanine are present together. It is possible. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] In this specification, the unit of content "mass%" is synonymous with "g / 100 g".

[0014] The composition for external use on the skin of the present invention comprises: (A) 3% by mass or more of nicotinamide; (B) The group consisting of hyaluronic acid, its derivatives, their salts, and heparinoids. Two or more selected from the following: (C) Amphiphilic Compounds A skin external composition comprising:

[0015] [(A) Nicotinamide] The nicotinamide contained in the composition for external use on the skin of the present invention is nicotinic acid (vitamin B3 / Nicotinic acid is an amide compound of niacin and is a water-soluble vitamin. The extract may be a product of the first invention or a product synthesized by a known method. You can use the ones listed in the 7th Revised Japanese Pharmacopoeia. They have the effect of promoting blood circulation and treating rough skin. In addition to its improving effect, it is also known to have a melanin production inhibitory effect and a whitening effect.

[0016] In the composition for external use on the skin of the present invention, the content of component (A) in the total amount of the composition is The content of component (A) is appropriately set based on the total amount of the composition. From the viewpoint of providing sufficient effectiveness in whitening, anti-aging, etc., the content is preferably 3% by mass or more. Preferably, the content is 4% by mass or more, and more preferably, 5% by mass or more. The content of the component A is preferably 20% by mass or less, more preferably 20% by mass or less, based on the total amount of the composition. is 15% by mass or less, more preferably 10% by mass or less, particularly preferably 8% by mass or less. The content of the component (A) is preferably 3% by mass to 20% by mass based on the total amount of the composition. %, more preferably 3% by mass to 15% by mass, and even more preferably 3% by mass to 10% by mass. %, and even more preferably, it is 3% by mass to 8% by mass.

[0017] [(B) Hyaluronic acid, its derivatives, their salts, and heparinoids Two or more selected from the group Hyaluronic acid is a type of acidic mucopolysaccharide, composed of glucuronic acid and N-acetylglucosamine. Hyaluronic acid is a polysaccharide that contains disaccharide units of amino acids. It is found in chicken combs, shark skin, and umbilicus. Animal tissues such as the girdle, eyeball, skin, and cartilage, and hyaluronic acid from microorganisms such as Streptococcus It can be extracted and recovered from cultures of acid-producing microorganisms, animal cells, or plant cells. Alternatively, it can be purchased commercially.

[0018] As described above, hyaluronic acid extracted from animal tissues, microorganisms, etc. generally has an average molecular weight of It is known that the molecular weight of the molecule is about 1 million or more and that it is an extremely high molecular weight. Alternatively, a hyaluronic acid having a high molecular weight such as hyaluronic acid obtained by decomposing a high molecular weight hyaluronic acid may be used. Low molecular weight hyaluronic acid may be used. Low molecular weight hyaluronic acid is a salt of high molecular weight hyaluronic acid. A method of hydrolyzing the compound in the presence of an acid or alkali, such as an acid, using an enzyme such as hyaluronidase, or by physically cutting it with ultrasonic waves or shearing it, or by fermenting it with microorganisms. Low molecular weight hyaluronic acid can be obtained by purchasing a commercial product. In the skin topical composition of the present invention, a low molecular weight compound is preferably used, but not limited to. Hyaluronic acid, hyaluronic acid oligosaccharides such as 4-, 6-, and 8-saccharides, and D-glucuronic acid Unsaturated hyaluronic acid having double bonds at the 5- and 6-positions is used.

[0019] The average molecular weight of hyaluronic acid is not particularly limited as long as the effects of the present invention are achieved. For example, The range is about 1 to 5 million. This makes it possible to more effectively achieve the effects of the present invention. From this viewpoint, the average molecular weight of the hyaluronic acid of the present invention is preferably about 100 to 700,000. More preferably, it is about 2,000,000 to 600,000, and even more preferably, it is about 4,000,000 to 500,000. , even more preferably about 5,000 to 400,000, and particularly preferably about 8,000 to 2,000,000 It is.

[0020] When low molecular weight hyaluronic acid is used, the average molecular weight is from the viewpoint of significantly exhibiting the effects of the present invention. Preferably, it is about 1,000,000 to 350,000, more preferably about 1,000,000 to 100,000, and even more preferably about 1,000,000 to 100,000. The most preferred range is about 200,000 to 50,000, even more preferably about 200,000 to 30,000, and particularly preferably Preferably around 500 to 20,000.

[0021] In this specification, the average molecular weight means the weight average molecular weight. The weight average molecular weight is It can be determined by a known measurement method. Specifically, it is possible to measure the amount of the ion exchange reaction by size exclusion chromatography. The measurement conditions are as follows: (Column: TSKgel GMPWXL 7 .8mm×30cm (Tosoh Corporation), Column temperature: constant temperature around 40℃, Detector: Differential refractometer, mobile phase: 0.2mol / L NaCl, flow rate: 0.3mL / min, injection volume: 100 μL, standard substance: pullulan standard (STANDARD P-82, Showa Denko Co., Ltd.) It is manufactured by

[0022] The derivative of hyaluronic acid is not particularly limited as long as it is pharmacologically or physiologically acceptable. For example, acetylated hyaluronic acid in which the hydroxyl group is acetylated, and Sulfated hyaluronic acid, cationized hyaluronic acid, hydrophobized hyaluronic acid Decomposed hyaluronic acid (hydrolyzed hyaluronic acid alkyl (C12-13) glyceryl, etc.), cross-linked Hyaluronic acid, carboxymethyl hyaluronic acid, alkylene glycol hyaluronate, Examples of the hyaluronic acid silanol and / or salts thereof include hyaluronic acid silanol and / or salts thereof. The acid derivatives are preferably acetylated hyaluronic acid, hyaluronic acid hydroxypropyl ester, and hyaluronic acid hydroxypropyl ester. Lopyrtrimonium, Hydrolyzed Hyaluronate Alkyl (C12-13) Glyceryl, Cal carboxymethyl hyaluronic acid, crosslinked hyaluronic acid, dimethylsilanol hyaluronate, Propylene glycol hydroxyl group and / or salts thereof are preferably used. Acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, cross-linked hyaluronic acid uronic acid, dimethylsilanol hyaluronate, propylene glycol hyaluronate and Or a salt thereof may be used.

[0023] Salts of hyaluronic acid or its derivatives are also usable, as long as they are pharmacologically or physiologically acceptable. Examples of the metals include, but are not limited to, alkali metals such as sodium and potassium, calcium, magnesium, etc. Salts with alkaline earth metals such as sodium, zinc, aluminum, and other metals, and ammonium salts Examples of the salt include basic amino acid salts, amine salts such as triethanolamine, etc. Preferably, the salt of hyaluronic acid or a derivative thereof is a sodium salt, a potassium salt, A zinc salt is used. Specific examples of salts of hyaluronic acid or its derivatives include hyaluronic acid Sodium hyaluronate, potassium hyaluronate, calcium hyaluronate, malic acid hyaluronate Magnesium, Zinc Hyaluronate, Ammonium Hyaluronate, Monoethanolamine Hyaluronate Aminolic acid, sodium acetylated hyaluronate, potassium acetylated hyaluronate, acetylated hyaluronate, Acetylated Calcium Hyaluronate, Acetylated Magnesium Hyaluronate, Acetylated Hyaluronate Zinc hyaluronate, ammonium acetylated hyaluronate, sodium hyaluronate crosspolymer hyaluronic acid hydroxypropyltrimonium, etc.

[0024] The composition for external use on the skin of the present invention comprises hyaluronic acid, its derivatives, salts thereof, and Two or more selected from the group consisting of heparinoids are used in combination. A) 3% by mass or more of nicotinamide, and component (B) hyaluronic acid, its derivatives, and two or more heparinoids selected from the group consisting of However, by further incorporating an amphiphilic compound (C), coloring can be prevented. The composition for external use on the skin of the present invention contains hyaluronic acid, acetylated hyaluronic acid, and hydrolyzed hyaluronic acid. Degraded hyaluronic acid, cationized hyaluronic acid, cross-linked hyaluronic acid, and heparins It is preferable that the composition contains at least two or more substances selected from the group consisting of similar substances.

[0025] The hyaluronic acid, its derivatives, and their salts used in the present invention are commercially available products. For example, hyaluronic acid can be obtained by using the product name "Sodium Hyaluronate HA12 N" (Shiseido Co., Ltd.) Average molecular weight 1.1 to 1.6 million, product name "Hyaluronic Acid FCH-1 50" (Kikkoman Biochemifa Corporation) Average molecular weight 1.4 to 1.8 million, product name " Bio-sodium hyaluronate SZE (Shiseido Co., Ltd.) Average molecular weight: 1.1-1.6 million , product name "Hyaluronic Acid FCH-120" (Kikkoman Biochemifa Corporation) average Molecular weight 1-1.4 million, product name "Hyaluronic Acid HA-LQ" (Kewpie Corporation) Average molecular weight: 850,000 to 1,600,000; product name: Hyaluronic Acid FCH-80 (Kikkoman Bio Chemipha Corporation) Average molecular weight 600,000 to 1,000,000, product name "Hyaluronic acid FCH-60" ( Kikkoman Biochemifa Corporation) Average molecular weight 500,000 to 700,000, product name "Hyaluronic Acid FCH-SU" (Kikkoman Biochemifa Corporation), average molecular weight 50,000 to 110,000, product name "Hyaluronic acid (L)" (FAP Japan Co., Ltd.) Average molecular weight less than 50,000, product name "Hyaluronic acid (L)" Rooligo (Kewpie Corporation) Average molecular weight less than 10,000, product name "Hyaluronic acid (SL) (FAP Japan Co., Ltd.) Average molecular weight of 10,000 or less, product name "Micro Hyaluronic Acid FC" H" (Kikkoman Biochemifa Corporation) average molecular weight of 5000 or less) As a derivative of hyaluronic acid, the product name "Sodium Acetylated Hyaluronate" is available. (Shiseido Co., Ltd.) Average molecular weight: 10,000 to 100,000, product name: "Hyaloveil" (Kewpie Corporation) Company) Average molecular weight 500,000 to 800,000, product name "Hyalopair" (Kewpie Corporation) Average molecular weight Molecular weight less than 10,000, product name "Hyalujon" (Kikkoman Biochemifa Corporation), product Name: "Hyalocatch" (Kewpie Corporation) Average molecular weight: 800,000 to 1,200,000; product name: Arcage System" (IRAsrl), product name "DSHCN6" (EXSY Examples include commercially available products such as MOL SAM.

[0026] Heparinoids are a general term for polysulfated mucopolysaccharides such as chondroitin polysulfate. 0.5 to 5 molecules on average, preferably 0.6 to 3 molecules on average, per one monosaccharide molecule constituting the copolysaccharide More specifically, the heparinoid is heparin, conjugate, or the like. Contains chondroitin sulfate D and chondroitin sulfate E, also known as droitin polysulfate. do.

[0027] Heparinoids can also be obtained by sulfated mucopolysaccharides, and are derived from bovine and bronchial Extraction and purification are performed using aqueous carriers from the internal organs of animals, including the bronchi, such as mice, and then, if necessary, Such heparinoids can also be obtained by sulfation, depending on the case. Since it has been developed as a cosmetic ingredient, such commercially available products can also be used.

[0028] In the skin external composition of the present invention, the heparinoid is Those that are available in the market are preferably used.

[0029] In the skin topical composition of the present invention, the combination of component (B) is preferably hyaluronic acid, Among two or more of its derivatives and their salts, acetylated hyaluronic acid, cationized hyaluronic acid, It is preferable that the composition contains hyaluronic acid, crosslinked hyaluronic acid, or a salt thereof. At least sodium hyaluronate, acetylated sodium hyaluronate, hyaluronic acid Crosspolymer sodium or hydroxypropyltrimonium hyaluronate or at least sodium acetylated hyaluronate and heparin More preferably, it is combined with a hyaluronic acid analogue, at least sodium hyaluronate. , acetylated sodium hyaluronate, sodium hyaluronate crosspolymer, or It contains hydroxypropyltrimonium hyaluronate and is combined with a heparinoid. It is particularly preferred that they are combined. Among them, the combination of component (B) is acetylated hyaluronic acid and sodium hyaluronate. Thorium, Acetylated Hyaluronic Acid and Zinc Hyaluronate, Acetylated Hyaluronic Acid and Low Fraction Hyaluronic acid, acetylated hyaluronic acid and low molecular weight zinc hyaluronate, acetylated hyaluronic acid hyaluronic acid and hydroxypropyltrimonium hyaluronate, acetylated hyaluronic acid and hydrolyzed Decomposed hyaluronic acid alkyl (C12-13) glyceryl, acetylated hyaluronic acid and calcium carboxymethyl hyaluronic acid, acetylated hyaluronic acid and cross-linked hyaluronic acid, acetylated Hyaluronic acid and hyaluronate dimethylsilanol, acetylated hyaluronic acid and hyaluronate Propylene glycol, acetylated hyaluronic acid, and a combination of acetylated hyaluronic acid and heparinoids. A combination of Acetylated hyaluronic acid and sodium hyaluronate, Acetylated hyaluronic acid and hyaluronic acid Zinc hyaluronic acid, acetylated hyaluronic acid and low molecular weight hyaluronic acid, acetylated hyaluronic acid and Low molecular weight zinc hyaluronate, acetylated hyaluronate and hydroxypropyl hyaluronate Limonium, acetylated hyaluronic acid and hyaluronic acid dimethylsilanol, acetylated hyaluronic acid Hyaluronic acid and propylene glycol hyaluronate and acetylated hyaluronic acid and heparin A combination of imitation amines is more preferred. Acetylated hyaluronic acid and sodium hyaluronate, acetylated hyaluronic acid and low molecular weight Hyaluronic Acid, Acetylated Hyaluronic Acid and Hydroxypropyltrimonium Hyaluronate and a combination of acetylated hyaluronic acid and a heparinoid. I wish. In another embodiment, the combination of the component (B) is hyaluronic acid crosslinker. Sodium hyaluronate, sodium hyaluronate crosspolymer, Zinc hyaluronate, sodium hyaluronate crosspolymer and low molecular weight hyaluronic acid, Sodium hyaluronate crosspolymer and low molecular weight zinc hyaluronate, hyaluronic acid crosspolymer Sodium hyaluronate and hydroxypropyltrimonium hyaluronate, hyaluronic acid crosspo Sodium hyaluronate and hydrolyzed alkyl (C12-13) glyceryl hyaluronate, Sodium hyaluronic acid crosspolymer and carboxymethyl hyaluronic acid, hyaluronic acid crosspolymer Polymer sodium and hyaluronic acid dimethylsilanol, hyaluronic acid crosspolymer sodium Sodium, propylene glycol hyaluronate, and hyaluronic acid crosspolymer A combination of thorium and a heparinoid is preferred. In another embodiment, the combination of the component (B) is hyaluronic acid hydroxyl. Cypropyltrimonium and sodium hyaluronate, hydroxypropyl hyaluronate Limonium and Zinc Hyaluronate, Hydroxypropyltrimonium Hyaluronate and Low Molecular Weight Hyaluronic acid, hydroxypropyltrimonium hyaluronate and low molecular weight zinc hyaluronate , hydroxypropyltrimonium hyaluronate and cross-linked hyaluronic acid, hyaluronic acid Hydroxypropyltrimonium and hydrolyzed alkyl hyaluronate (C12-13) glycerol lysyl, hydroxypropyltrimonium hyaluronate and carboxymethyl hyaluronate, Hydroxypropyltrimonium hyaluronate and dimethylsilanol hyaluronate, Hydroxypropyltrimonium Hyaluronate and Propylene Glycol Hyaluronate, and A combination of hydroxypropyltrimonium hyaluronate and a heparinoid is preferred. It is nice. In addition, as for a combination of three or more types, at least acetylated hyaluronic acid and hyaluronic acid sodium hyaluronic acid, or at least acetylated hyaluronic acid and low molecular weight hyaluronic acid or at least acetylated hyaluronic acid and hydroxypropyl hyaluronate Two types of hyaluronic acid, or at least acetylated hyaluronic acid and hyaluronic acid crosslinker Two types of polymeric sodium, or at least acetylated hyaluronic acid and heparin-like Two substances, or at least hydroxypropyltrimonium hyaluronate and hyaluronic acid Two types of sodium hyaluronate or at least hydroxypropyltrimonium hyaluronate Two types of hyaluronic acid are used: hyaluronic acid and low molecular weight hyaluronic acid, or at least hyaluronic acid crosspolymer natto. Hyaluronic acid crosspolymer and sodium hyaluronate, or at least hyaluronic acid crosspolymer. A combination of three or more types including two types of hyaluronic acid, sodium hyaluronate and low molecular weight hyaluronic acid, is preferred. Acetylated hyaluronic acid, sodium hyaluronate, low molecular weight hyaluronic acid, acetylated Hyaluronic Acid, Sodium Hyaluronate, and Hydroxypropyltrimonium Hyaluronate , hydroxypropyltrimonium hyaluronate, sodium hyaluronate and low molecular weight hyaluronate Hyaluronic acid, hyaluronic acid crosspolymer sodium and sodium hyaluronate and low molecular weight hyaluronic acid Hyaluronic acid, acetylated hyaluronic acid, sodium hyaluronate, heparinoids, Hydroxypropyltrimonium hyaluronate, sodium hyaluronate, and heparin analogues Quality, Sodium Hyaluronate Crosspolymer and Sodium Hyaluronate and Heparin Analogues Quality, acetylated hyaluronic acid, low molecular weight hyaluronic acid and hydroxypropyl hyaluronic acid Limonium, acetylated hyaluronic acid, low molecular weight hyaluronic acid, heparinoids, hyaluronic acid Hydroxypropyltrimonium hyaluronate, low molecular weight hyaluronic acid, and heparinoids, The compound is a combination of sodium hyaluronate crosspolymer, low molecular weight hyaluronate, and heparinoid. More preferably, it includes a combination.

[0030] In the composition for external use on the skin of the present invention, the total content of the component (B) is not particularly limited, and may be any amount other than that of the other components. The composition is appropriately set depending on the type of the synthetic component, etc., but from the viewpoint of significantly exhibiting the effects of the present invention, Preferably, the content is 0.0001% by mass or more, more preferably 0.0005% by mass or more, based on the total amount of the composition. % by mass or more, more preferably 0.001% by mass or more, and even more preferably 0.0 It is preferably 0.01% by mass or more, and particularly preferably 0.001% by mass or more. The total content of the (B) component is preferably 5% by mass or less, more preferably 5% by mass or less, based on the total amount of the composition. Preferably, the content is 3% by mass or less, more preferably 2% by mass or less, and even more preferably 1% by mass or less. % by mass or less, particularly preferably 0.5% by mass or less. The total content of the component (B) is preferably 0.0001 to 5 mass% based on the total amount of the composition. , more preferably 0.0005 to 3 mass%, further preferably 0.001 to 2 mass%, More preferably, the content is from 0.001 to 1 mass%, and particularly preferably, from 0.001 to 0.5 mass%. %.

[0031] In the composition for external use on skin of the present invention, the ratio of the total content of component (B) to component (A) is Although not particularly limited, the ratio of the (B) component to 1 part by mass of the (A) component is preferably 0.00 0.001 to 2 parts by mass, more preferably 0.0005 to 1 part by mass, and even more preferably 0.00 The content is 1 to 0.1 parts by mass.

[0032] In the composition for external use on the skin of the present invention, the content of hyaluronic acid, its derivatives, and The total content of the salts thereof is not particularly limited as long as the effects of the present invention are achieved. The total content of hyaluronic acid, its derivatives, and their salts is based on the total amount of the composition. , preferably 0.00001% by mass or more, more preferably 0.0001% by mass or more, More preferably, it is 0.001 mass % or more. The total content of hyaluronic acid, its derivatives, and their salts is based on the total amount of the composition. , preferably 2% by mass or less, more preferably 1% by mass or less, and even more preferably 0. The content is 5% by mass or less. The total content of hyaluronic acid, its derivatives, and their salts is based on the total amount of the composition. , preferably 0.00001 to 2 mass%, more preferably 0.0001 to 1 mass%, More preferably, it is 0.001 to 0.5% by mass.

[0033] In the skin topical composition of the present invention, the content of the heparinoid alone relative to the total amount of the composition The amount is not particularly limited as long as the effects of the present invention are achieved. The content of the heparinoid is preferably 0.005% by mass or more based on the total amount of the composition. More preferably, the content is 0.001% by mass or more, and even more preferably, the content is 0.01% by mass or more. Particularly preferably, it is 0.1 mass % or more. The content of the heparinoid is preferably 10% by mass or less, more preferably 10% by mass or less, based on the total amount of the composition. More preferably, it is 5% by mass or less, even more preferably, it is 1% by mass or less, and particularly preferably, it is 0. The content is 5% by mass or less. The content of the heparinoid is preferably 0.005 to 10 mass % based on the total amount of the composition. %, more preferably 0.001 to 5 mass%, and even more preferably 0.01 to 1 mass%. The content is particularly preferably 0.1 to 1% by mass.

[0034] [(C) Amphiphilic component] An amphiphilic component is a molecule that contains both hydrophilic and hydrophobic groups (lipophilic groups). As a result, it refers to all compounds that have affinity for both the aqueous phase and the oil phase (organic phase).

[0035] Such an amphiphilic component is not particularly limited, but may be, for example, an alkylene oxide. Derivatives, phosphorylcholine-containing polymers, dicarboxylic acid esters, and alkyl groups with 5 to 10 carbon atoms Examples of the component (C) of the present invention include: These compounds can be used alone or in combination of two or more. By blending the component (A) and the component (B), a high concentration of nicotine is obtained. It is possible to provide a composition for external use on the skin that is inhibited from discoloring even when an acid amide is blended therein. It becomes possible.

[0036] The component (C) is preferably an alkylene oxide derivative represented by the following general formula (I): 2-Methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer, (Ethyl Decaglyceryl icosane diacid / tetradecane diacid, bis(cyclohexanedicarboxylate), Toxicdiglycol, diethylhexyl succinate, diethoxyethyl succinate, and carbon black. The alkanediol is one or more selected from alkanediols having 5 to 10 prime numbers.

[0037] [ka] (In the formula, Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms, which has n hydroxy groups. means the residue obtained by removing; AO means an oxyalkylene group having 3 to 4 carbon atoms; EO means an oxyethylene group; BO means an oxyalkylene group having 4 carbon atoms; n is 1 to 9; a, b, and c each represent the average number of moles of AO, EO, and BO added, and are independently 0 to The number is 200. However, a, b, and c cannot all be 0. Also, when n is 2 or more, Each of the multiple a's, b's, and c's may be the same or different. When Z is a hydrogen atom, n is 1. do. In addition, AO and EO may be added randomly or in the form of a block.

[0038] In order to provide a skin topical composition which is inhibited from discoloring, the alkylene oxide derivative is preferably a compound represented by the following general formula (II).

[0039] [ka] (In the formula, Z is a hydrogen atom or a hydroxy compound having 1 to 30 carbon atoms, which has n hydroxy groups. means the residue obtained by removing; AO means an oxyalkylene group having 3 to 4 carbon atoms; EO means an oxyethylene group; n is 1 to 9; a and b each represent the average number of moles of AO and EO added, and are independently 0 to 200. However, a and b cannot all be 0. Also, when n is 2 or more, multiple a and b They may be the same or different. When Z is a hydrogen atom, n is 1. In addition, AO and EO may be added randomly or in the form of a block.

[0040] The alkylene oxide derivative used in the present invention is a polymerizable compound obtained by polymerization of a specific alkylene glycol. (when Z is a hydrogen atom) or a specific hydroxy compound (corresponding to Z) with a specific aryl group. An alkylene oxide group (corresponding to the portion excluding Z in general formulas (I) and (II)) is added (Z is a compound obtained by removing n hydroxy groups from a hydroxy compound having 1 to 30 carbon atoms.) (In the case where the group is a group obtained by

[0041] In the alkylene oxide derivative used in the present invention, a skin preparation for external use in which coloring is suppressed is From the viewpoint of providing a composition, AO is an oxyalkylene group having 3 to 4 carbon atoms, for example: Oxypropylene group, oxybutylene group (oxy n-butylene group, oxyisobutylene group oxyt-butylene group, oxytrimethylene group, oxytetramethylene group, etc. AO is preferably an oxypropylene group, an oxybutylene group, more preferably It is an oxypropylene group.

[0042] In the alkylene oxide derivative used in the present invention, BO is an oxyalkyl having 4 carbon atoms. Examples of the butylene group include oxybutylene (oxy n-butylene, oxyisobutylene). oxytetramethylene group, etc. are preferably used. It is an oxybutylene group.

[0043] In the alkylene oxide derivative used in the present invention, a, b, and c each independently represent a and b each independently represents an integer of 0 to 200, and More preferably, it is from 2 to 70, even more preferably from 2 to 50, and particularly preferably It is 2 to 20. c is preferably 2 to 150. In another embodiment, c is preferably 0.5 to 100, more preferably 0.8 to 50, and further Preferably, it is 1 to 30.

[0044] In chemical formula (I), a+b+c is the total number of AO, EO, and BO monomer units. From the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 3 or more, more preferably 5 or more, More preferably, it is 10 or more. In addition, a+b+c is a value from the viewpoint of exhibiting the effects of the present invention remarkably. , preferably 400 or less, more preferably 300 or less, and even more preferably 250 or less, Particularly preferably, it is 200 or less.

[0045] In the chemical formula (II), the total number of AO and EO monomer units, a+b, is From the viewpoint of exhibiting a remarkable brightness effect, it is preferably 3 or more, more preferably 5 or more, and further preferably It is preferably 10 or more. In addition, a+b is preferably 10 or more from the viewpoint of significantly exhibiting the effects of the present invention. Preferably, the ratio is 300 or less, more preferably 250 or less, even more preferably 200 or less, and particularly preferably is less than 150.

[0046] In the above formulas (I) and (II), the objective is to provide a composition for external use on the skin in which coloring is suppressed. Z is a hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms; Glycerin, trimethylolpropane, erythritol, pentaerythritol, alkyl Glycoside, diglycerin, xylitol, dipentaerythritol, sorbitol, n hydroxyl groups from inositol, sucrose, trehalose, or maltitol The residues obtained by removing the It is preferably a hydrogen atom or an alkyl group having 4 to 24 carbon atoms. Monoalcohols, glycerin (there are 3 hydroxyl groups to which alkylene oxide groups can be added) ), alkylglucoside having 1 to 24 carbon atoms (hydrazine to which an alkylene oxide group can be added) 4 hydroxy groups), diglycerin (4 hydroxy groups to which alkylene oxide groups can be added) 4 hydroxy groups) or sorbitol (6 hydroxy groups to which alkylene oxide groups can be added) more preferably, the residue is obtained by removing n hydroxy groups from A hydrogen atom or an alkyl monoalcohol having 4 to 24 carbon atoms, glycerin, It is a residue obtained by removing n hydroxyl groups from diglycerol. More preferred are alkyl monoalcohols having 4 to 24 carbon atoms, glycerin, and diglycerin. It is more preferable that the residue is obtained by removing n hydroxy groups from stomach.

[0047] In the chemical formula (I) or (II), Z is an alkyl monoalcohol having 4 to 24 carbon atoms. In this case, from the viewpoint of exhibiting the effects of the present invention remarkably, butyl alcohol, tetradecyl Tetraalcohol, cetanol, and stearyl alcohol are preferred, and butyl alcohol, Tetradecyl tetraalcohol is particularly preferred.

[0048] In the chemical formula (I) or (II), when Z is an alkyl glucoside, the effect of the present invention is Among them, alkylglucosides having 1 to 24 carbon atoms are preferred from the viewpoint of significantly achieving the above-mentioned effects. Alkyl glucosides having 1 to 16 carbon atoms are more preferred, and alkyl glucosides having 1 to 10 carbon atoms are more preferred. is even more preferred, and alkylglucosides having 1 to 5 carbon atoms are particularly preferred.

[0049] Such alkylene oxide derivatives can be synthesized by known methods. For example, Hydroxy compounds having 1 to 30 carbon atoms, ethylene oxide, and alkoxy compounds having 3 to 4 carbon atoms. After addition polymerization of alkylene oxide, it is reacted with alkylene oxide having 4 carbon atoms. In addition, the hydroxy compound having 1 to 30 carbon atoms is mixed with ethylene oxide and In the step of addition polymerization of alkylene oxide having 3 to 4 carbon atoms, ethylene oxide and The alkylene oxide may be randomly polymerized or block polymerized. In the reaction, an alkali catalyst, a phase transfer catalyst, a Lewis acid catalyst, etc. can be used. For this purpose, it is preferable to use an alkali catalyst such as potassium hydroxide.

[0050] The molecular weight of such an alkylene oxide derivative is not limited as long as the effect of the present invention is exhibited. However, from the viewpoint of significantly exhibiting the effects of the present invention, it is preferably 120 or more, and more preferably Preferably, it is 200 or more, more preferably, it is 300 or more, and particularly preferably , more than 400.

[0051] The properties of the alkylene oxide derivative are not limited as long as the effects of the present invention are exhibited. In the formulas (I) and (II), from the viewpoint of significantly exhibiting the effects of the present invention, preferably, The component is preferably in a semi-solid (including a paste-like form) to liquid form at 25°C.

[0052] In addition, such alkylene oxide derivatives include, for example, polyoxyalkylene glycerides. alkyl ether, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyalkylene sorbitol, polyoxyalkylene erythritol ether ether, polyoxyalkylene pentaerythritol ether, polyoxyalkylene di Glyceryl ether, polyoxyalkylene trimethylolpropane, polyoxypropionate Polyoxyethylene polyoxypropylene glycol, polyoxyal xylitol, polyoxyalkylene dipentaerythritol, polyoxyalkyl Leninositol, Polyoxyalkylene sucrose ether, Polyoxyalkylene Examples include lehalose ether, polyoxyalkylene maltitol ether, and the like. Among them, the alkylene oxide derivatives include polyoxyethylene glyceryl ether, poly Oxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl Ether, Polyoxybutylene Polyoxyethylene Polyoxypropylene Glyceryl Ether, Polyoxybutylene Polyoxyethylene Polyoxypropylene Alkyl Gluco , polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside Polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene Alkyl ether, polyoxypropylene sorbitol, polyoxyethylene sorbitol, Polyoxypropylene erythritol ether, polyoxyethylene erythritol ether Polyoxyethylene pentaerythritol ether, polyoxyethylene polyoxy Polyoxypropylene erythritol ether, polyoxypropylene pentaerythritol ether Polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene Polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, poly Oxyethylene polyoxypropylene diglyceryl ether, polyoxyethylene trime Trimethylolpropane, Polyoxypropylene, Trimethylolpropane, Polyoxyethylene Polyoxypropylene trimethylolpropane, polyoxypropylene glycol, poly Oxyethylene polyoxypropylene glycol, polyoxybutylene polyoxyethylene Polyoxypropylene glycol, polyoxyethylene xylitol, polyoxypropylene Pyrene alkylene xylitol, polyoxyethylene polyoxypropylene xylitol , polyoxyethylene polyoxypropylene dipentaerythritol, polyoxyethylene Polyoxypropyl pentaerythritol, polyoxyethylene Polyoxyethylene inositol, polyoxypropylene inositol, polyoxyethylene polyoxy Dipropylene inositol, polyoxyethylene sucrose ether, polyoxypropylene sucrose ether, polyoxyethylene polyoxypropylene sucrose ether , polyoxyethylene trehalose ether, polyoxypropylene trehalose ether Polyoxyethylene polyoxypropylene trehalose ether, polyoxyethylene Polyoxypropylene maltitol ether, polyoxypropylene maltitol ether, and polyoxypropylene maltitol ether and preferably one or more selected from the group consisting of ethylene polyoxypropylene ethers, Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxy Diethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside Coside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether Polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene Sorbitol, polyoxyethylene sorbitol, polyoxyethylene polyoxypropylene Pentaerythritol ether, polyoxyethylene diglyceryl ether, polyoxyethylene Dipropylene diglyceryl ether, polyoxyethylene polyoxypropylene trimethyl Rollpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene Pyrene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene More preferably, one or more selected from ethylene glycol, Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, Polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene poly Oxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxy Diethylene polyoxypropylene alkyl glucoside, polyoxypropylene alkyl glucoside Glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside Coside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene Polyoxyethylene alkyl ether, polyoxyethylene diglyceryl ether, polyoxypropylene Diglyceryl ether, polyoxypropylene glycol, polyoxyethylene polyoxyethylene Polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxy More preferably, one or more selected from propylene glycol, Polyoxyethylene methyl glucoside, Polyoxypropylene methyl glucoside, Poly Oxyethylene polyoxypropylene butyl ether, polyoxyethylene polyoxypropylene Propylene decyl tetradecyl ether, polyoxybutylene polyoxyethylene polyoxy Propylene methyl glucoside, polyoxypropylene diglyceryl ether, polyoxy Diethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene Glyceryl ethers are particularly preferred.

[0053] These alkylene oxide derivatives are UNILUBE 50MB-26 (polyoxyethylene Polyoxypropylene butyl ether (17E.O.) (17P.O.)), Unilube 5 0MB-168 (Polyoxyethylene polyoxypropylene butyl ether (37E.O .)(38P.O.)), Sorbure GS-01 (Polyoxyethylene polyoxypropyl Polydecyl tetradecyl ether (24E.O.) (30P.O.), Uniol HS-1 600D (PPG-25 sorbitol), Pronon #208 (PEG / PPG-150 / 3 5 copolymer), Pronon #124P (Polyoxyethylene (20) Polyoxypropylene (20) glycol), Pronon #184R (Polyoxyethylene (26) Polyoxy Propylene (30) glycol), Uniol D-2000 (PPG-34), Macbio Bride MG10E (Polyoxyethylene methyl glucoside (10E.O.)), Makubi Obride MG-20E (Polyoxyethylene methyl glucoside (20E.O.)), Cubiobride MG-10P (Polyoxypropylene methyl glucoside (10P.O.) , Macbiobride MG-20P (Polyoxypropylene methyl glucoside (20P.O .)), Wilbride MG2070 (Polyoxybutylene Polyoxyethylene Polyoxy Dipropylene methylglucositol), Unilube 5TP-300KB (PEG-5- / PP G-65 Pentaerythrityl; Unilube 50TG-32 (Polyoxyethylene Polyoxyethylene) Propylene Glyceryl Ether (24E.O.) (24P.O.), Wilbride S-753 (Polyoxybutylene Polyoxyethylene Polyoxypropylene Glyceryl Ethylene) (3B.O.) (8E.O.) (5P.O.)), Uniox G-1200 (Grise Res-26) (all manufactured by NOF Corporation); SY-DP14 (PPG-14 Polyglyceryl -2 ether), SY-DP9 (PPG-9 diglyceryl) (both from Sakamoto Pharmaceutical Co., Ltd. Newpol GP-1000 (PPG-16 glyceryl ether), Newpol SP-750 (PPG-10 sorbitol), Newpol PE-68 (PEG / PP G-160 / 30 copolymer), Newpol PE-78 (PEG / PPG-150 / 3 5 copolymer) (all manufactured by Sanyo Chemical Industries, Ltd.); Emulgen PP-290 (PEG / PP G-160 / 30 copolymer, manufactured by Kao Corporation); GlucamE-10 (polyoxyethylene ethylene methyl glucoside (10E.O.), GlucamP-10 (polyoxypropion 10E.O.)), GlucamP-20 (Polyoxypropylene SG-DTD6 30 (Polyoxyethylene polyoxypropylene decyl tetradecyl ether (30E. O.)(6P.O.)), SG-DTD620 (Polyoxyethylene polyoxypropylene Decyl tetradecyl ether (20E.O.) (6P.O.)), PEN4612 (Polyoxygen Diethylene polyoxypropylene decyl tetradecyl ether (12E.O.) (6P.O .)), PBC-34 (Polyoxyethylene polyoxypropylene cetyl ether (20E .O.)(4P.O.)), SG-G2424 (Polyoxyethylene polyoxypropylene Glyceryl ether (24E.O.) (24P.O.)) (above, Nikko Chemicals Co., Ltd. Dipropylene glycol (DPG) (both manufactured by ADEKA Corporation) and other names are available. is. As commercially available alkylene oxide derivatives, from the viewpoint of remarkably exhibiting the effects of the present invention, Unilube 50MB-26, Unilube 50MB-168, Solbure GS-01, Ronon #208, Pronon #124P, Pronon #184R, Uniol D-2000, MacBioBride MG-10E, MacBioBride MG-20E, MacBioBride MG -10P, Macbio Bride MG-20P, Wilbride MG2070, Unilube 5 TP-300KB, Unilube 50TG-32, Wilbride S-753, Unioc G-1200, SY-DP14, SY-DP9, Newpole GP-1000, New Pole PE-68, New Pole PE-78, Emulgen PP-290, SG-DTD6 30, SG-DTD620, and dipropylene glycol. It is preferable that the number of species is 1 or more. Unilube 50MB-26, Unilube 50MB-168, Solbure GS-01, Pronon #208, Pronon #124P, Pronon #184R, Macbio Bride MG- 10P, Macbio Bride MG-20P, Wilbride MG2070, Wilbride S-753, Unilube 50TG-32, SY-DP14, SY-DP9, Newpol PE-68, Newpol PE-78, Emulgen PP-290, SG-DTD630, and SG-DTD620. .

[0054] In the present invention, the alkylene oxide derivatives may be used alone or in combination. Any combination of the above may be used.

[0055] The phosphorylcholine-containing polymer is a polymer obtained by polymerizing an organic compound containing phosphorylcholine as a monomer. It refers to polymers in general that include the above-mentioned polymers. Among them, a monomer containing 2-methacryloyloxyethyl phosphorylcholine is polymerized. The polymer obtained by the above reaction is preferably a 2-methacryloyloxyphosphorylcholine-containing polymer. Among them, 2-methacryloyloxyethyl phosphorylcholine / butyric acid methacrylate is preferred. copolymer (Polyquaternium-51), and polymethacryloyloxyethyl phosphoryl Preferably, one or more selected from the group consisting of 2-methacryloyloxyalkylenes, Diethyl phosphorylcholine-butyl methacrylate copolymer is more preferred. Commercially available phosphorus-containing polymers include Lipidure-PMB (2-methacryloyloxy). Diethylphosphorylcholine-Butyl methacrylate copolymer liquid, Polyquaternium-51) , and Lipidure-HM (polymethacryloyloxyethyl phosphorylcholine) ( Preferably, one or more selected from the group consisting of Lipoic Acid, Lipoic Acid (all manufactured by NOF Corp.) dure-PMB (2-methacryloyloxyethyl phosphorylcholine methacrylate bromide) Chilled copolymer liquid) is more preferred

[0056] Dicarboxylic acid esters are compounds that combine dicarboxylic acids with glycols, glycol ethers, etc. It is an ester condensed with a hydroxy group, and is not particularly limited, for example, Neosolu e-Aqua Neosolue-AquaS ((Eicosane diacid / Tetradecanedioic acid) Polyglyceryl-10), Neosolue-Aqulio (Cyclohexanedicarbonate) bis(ethoxydiglycol) acetate (both manufactured by Nippon Fine Chemicals Co., Ltd.), 1,4-cyclohexane Bis(triethylene glycol monoethyl ether) dicarboxylate, bis(diethylene glycol ethylene glycol monoethyl ether), bis(triethylene glycol monoethyl ether) adipate ethyl ether), and diethoxyethyl succinate (CRODAMOL DES), succinate Diethylhexyl acetate (CRODAMOL OSU) (both manufactured by Croda Japan Co., Ltd.) ), among which Neosolue-Aqua and Neosolue-AquaS (( Eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10), Neosolue-Aq ulio (bisethoxydiglycol cyclohexanedicarboxylate), diethoxy succinate Diethylhexyl succinate (CRODAMOL DES), Diethylhexyl succinate (CRODAMOL OSU) is preferred, and Neosolue-Aqua Neosolue-AquaS ( (Eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10), Neosolue-A Qulio (bisethoxydiglycol cyclohexanedicarboxylate) is more preferred, Neosolue-Aqulio (Cyclohexanedicarboxylic acid bisethoxydiglycol is even more preferred.

[0057] In order to achieve the effects of the present invention more remarkably, the alkanediol preferably has 5 carbon atoms. The ratio is preferably from 1 to 10, more preferably from 5 to 8, and even more preferably from 5 to 6. For example, 1,2-penta Preferred are 1,2-hexanediol, 1,2-octanediol, and -pentanediol, 1,2-hexanediol are more preferred, and 1,2-pentanediol is more preferred. In addition, commercially available products include, but are not limited to, HYDROLITE (manufactured by Symrise Co., Ltd.) and KMO-6 (manufactured by Osaka Organic Chemical Industry Co., Ltd.) can be used.

[0058] In the present invention, the component (C) may be, in addition to the above alkylene oxide derivatives, 2- Methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer, (Eico Decaglyceryl tetradecane diacid / tetradecane diacid, bisethoxycyclohexane dicarboxylate Diglycol, diethylhexyl succinate, diethoxyethyl succinate, carbon number 5-1 Alkanediols having a molecular weight of 0 are preferred, and in addition to the above alkylene oxide derivatives, 2-methacrylamide, Trimethylsilyloxyethyl phosphorylcholine-butyl methacrylate copolymer, (eicosanol diethyl ester Decaglyceryl tetradecane diacid, bisethoxy cyclohexane dicarboxylate Recall: 1,2 pentanediol, 1,2 hexanediol, or 1,2 octanediol More preferred are 2-methacryloyl ols, in addition to the above alkylene oxide derivatives. Poly(ethylhexylcholine / butyl methacrylate) copolymer, (eicosanedioic acid / tetramethyl methacrylate) Decaglyceryl decanedioate, bisethoxydiglycol cyclohexanedicarboxylate, 1,2 pentanediol and 1,2 hexanediol are even more preferred. The components may be used alone or in any combination of two or more. stomach.

[0059] In the composition for external use on the skin of the present invention, the total content of the component (C) is not particularly limited, and The amount is appropriately set depending on the type of component and the type of other blended components, but it is possible to significantly exhibit the effects of the present invention. From this viewpoint, the content is preferably 0.001% by mass or more, more preferably 0.001% by mass or more, based on the total amount of the composition. is 0.005% by mass or more, more preferably 0.01% by mass or more, and even more preferably The content is preferably 0.05% by mass or more, and most preferably 0.1% by mass or more. The total content of the component (C) is preferably 20 mass % or less, more preferably 20 mass % or less, based on the total amount of the composition. Preferably, it is 15% by mass or less, more preferably, it is 12% by mass or less, and even more preferably, it is 15% by mass or less. , 10% by mass or less, and most preferably 8% by mass or less. The total content of the component (C) is preferably 0.001 to 20 mass% based on the total amount of the composition. , more preferably 0.005 to 15 mass%, further preferably 0.01 to 12 mass%, More preferably, it is 0.05 to 10% by mass, and most preferably, it is 0.1 to 8% by mass. .

[0060] In the composition for external use on skin of the present invention, the ratio of the total content of the component (C) to the component (B) is Although not particularly limited, the amount of the component (C) is preferably 0.01 part by mass per part by mass of the component (B). 0.05 to 10,000 parts by mass, and more preferably 0.05 to 50,000 parts by mass. .1 to 5000 parts by mass.

[0061] In the skin topical composition of the present invention, the ratio of the alkylene oxide derivative to the total amount of the composition is The content of the specific ingredient is not particularly limited as long as the effects of the present invention are achieved. The content of the alkylene oxide derivative alone is preferably 0. 0.1% by mass or more, more preferably 0.1% by mass or more, and even more preferably 1% by mass or more. It is. The content of the alkylene oxide derivative alone is preferably 15 to 20% by weight based on the total amount of the composition. % by mass or less, more preferably 10% by mass or less, and even more preferably 8% by mass or less. . The content of the alkylene oxide derivative alone is preferably 0. The content is preferably 0.01 to 15% by mass, more preferably 0.1 to 10% by mass, and even more preferably is 1 to 8 mass %.

[0062] In the skin topical composition of the present invention, the amount of (eicosane diacid / tetradecane diacid) relative to the total amount of the composition The content of decaglyceryl diacetate alone is not particularly limited as long as the effects of the present invention are achieved. . The content of decaglyceryl (eicosane diacid / tetradecane diacid) alone is the total amount of the composition. Preferably, it is 0.001% by mass or more, more preferably, 0.005% by mass or more. , more preferably 0.01% by mass or more, and even more preferably 0.05% by mass or more. It is. The content of decaglyceryl (eicosane diacid / tetradecane diacid) alone is the total amount of the composition. Preferably, the content is 15% by mass or less, more preferably, 10% by mass or less, and even more preferably Preferably, it is 8 mass % or less, and even more preferably, it is 5 mass % or less. The content of decaglyceryl (eicosane diacid / tetradecane diacid) alone is the total amount of the composition. Preferably, the content is 0.001 to 15 mass%, more preferably, 0.005 to 10 mass%. %, more preferably 0.01 to 8 mass%, and even more preferably 0.05 mass%. ~5% by mass.

[0063] In the composition for external use on the skin of the present invention, the amount of cyclohexanedicarboxylic acid bicarbonate relative to the total amount of the composition is The content of ethoxydiglycol alone is not particularly limited as long as the effects of the present invention are achieved. . The content of bis(ethoxydiglycol) cyclohexanedicarboxylate alone is the total amount of the composition. Preferably, it is 0.001% by mass or more, more preferably, 0.005% by mass or more. , more preferably 0.01% by mass or more, and even more preferably 0.05% by mass or more. It is. The content of bis(ethoxydiglycol) cyclohexanedicarboxylate alone is the total amount of the composition. Preferably, the content is 15% by mass or less, more preferably, 10% by mass or less, and even more preferably Preferably, it is 8 mass % or less, and even more preferably, it is 5 mass % or less. The content of bis(ethoxydiglycol) cyclohexanedicarboxylate alone is the total amount of the composition. Preferably, the content is 0.001 to 15 mass%, more preferably, 0.005 to 10 mass%. %, more preferably 0.01 to 8 mass%, and even more preferably 0.05 mass%. ~5% by mass.

[0064] In the skin external composition of the present invention, the amount of 2-methacryloyloxyethyl ether based on the total amount of the composition is The content of the polyphosphorylcholine-butyl methacrylate copolymer alone is not enough to achieve the effects of the present invention. As long as it is, there is no particular limitation. Monomer of 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer The content of the inorganic filler is preferably 0.0001% by mass or more, more preferably 0.0001% by mass or more, based on the total amount of the composition. Preferably, the content is 0.001% by mass or more, more preferably, 0.005% by mass or more, and even more preferably, It is preferably 0.01 mass % or more. Monomer of 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer The content of the component (I) is preferably 2% by mass or less, more preferably 1% by mass or less, based on the total amount of the composition. % by weight or less, more preferably 0.5% by weight or less, and even more preferably 0.2% by weight or less. The following is the result. Monomer of 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer The content of the inorganic filler is preferably 0.0001 to 2 mass%, more preferably 0.0001 to 2 mass%, based on the total amount of the composition. Preferably, the content is 0.001 to 1 mass%, more preferably, 0.005 to 0.5 mass%, and even more preferably, The content is more preferably 0.01% by mass to 0.2% by mass.

[0065] In the composition for external use on the skin of the present invention, the amount of the alkandiamine having 5 to 10 carbon atoms relative to the total amount of the composition is The content of the alcohol alone is not particularly limited as long as the effects of the present invention are achieved. The content of the alkanediol having 5 to 10 carbon atoms alone is preferably is 0.0001 mass% or more, more preferably 0.001 mass% or more, and even more preferably is 0.01% by mass or more, and even more preferably 0.1% by mass or more. The content of the alkanediol having 5 to 10 carbon atoms alone is preferably is 10% by mass or less, more preferably 7% by mass or less, and even more preferably 5% by mass or less. , and even more preferably 3 mass % or less. The content of the alkanediol having 5 to 10 carbon atoms alone is preferably is 0.0001 to 10 mass%, more preferably 0.001 to 7 mass%, and even more preferably The content is preferably 0.01 to 5% by mass, and even more preferably 0.1 to 3% by mass.

[0066] The composition for external use on the skin of the present invention further comprises chondroitin, from the viewpoint of exhibiting the effects of the present invention remarkably. It is preferred that it contains isotonic sulfate and / or a salt thereof. Chondroitin sulfate is made up of two components: D-glucuronic acid and N-acetyl-D-galactosamine. It is a type of glycosaminoglycan that has a structure in which sulfate is attached to a glycan chain with repeating sugars.

[0067] The chondroitin sulfate used in the present invention is pharmacologically or physiologically acceptable. As long as the cartilage is of a suitable origin, there is no particular limitation. For example, the cartilage may be derived from mammals or fish (salmon cartilage). Those derived from tissues such as bones can be used.

[0068] As the salt of chondroitin sulfate, any salt that is pharmacologically or physiologically acceptable may be used. The salt of chondroitin sulfate is not particularly limited. Specific examples of the salt of chondroitin sulfate include salts with organic acids [e.g. For example, monocarboxylates (acetates, trifluoroacetates, butyrates, palmitates, stearates, etc.) Phosphates, etc.), polycarboxylates (fumarates, maleates, etc.), oxycarboxylates Acid salts (lactates, tartrates, citrates, succinates, malonates, etc.), organic sulfonic acids salts (e.g., methanesulfonate, toluenesulfonate, tosylate, etc.), with inorganic acids Salts (e.g., hydrochlorides, sulfates, nitrates, hydrobromides, phosphates, etc.), salts with organic bases (e.g., methylamine, triethylamine, triethanolamine, morpholine, pipette salts with organic amines such as aldehyde, pyrrolidine, tripyridine, picoline, etc.) and salts with inorganic bases Salts [e.g., ammonium salts; alkali metal (sodium, potassium, etc.), alkaline earth Metals (calcium, magnesium, etc.), salts with metals such as aluminum, etc. .

[0069] These chondroitin sulfates and / or salts thereof may be used alone or in combination. In order to achieve the effects of the present invention more significantly, As chondroitin sulfate and / or a salt thereof, a salt of chondroitin sulfate with an inorganic base is preferred. Preferably, an alkali metal salt of chondroitin sulfate is used, and more preferably, sodium chondroitin sulfate is used. Sodium, potassium chondroitin sulfate, sodium dermatan sulfate, and dermatan sulfate More preferably, the chondroitin sulfate is at least one selected from the group consisting of potassium sulfate and chondroitin sulfate. Sodium chondroitinate and / or potassium chondroitin sulfate are particularly preferred. Chondroitin sulfate is also called chondroitin sulfate ester, and sodium chondroitin sulfate is chondroitin sulfate. It is also called sodium droitin sulfate.

[0070] In the composition for external use on the skin of the present invention, the amount of chondroitin sulfate and / or The total content of the salt is preferably 0.0001 to 10 mass%, more preferably 0.00 05 to 7 mass%, more preferably 0.001 to 5 mass%, and even more preferably 0. The content is preferably 0.005 to 3 mass %, and most preferably 0.01 to 1 mass %.

[0071] [Other ingredients] In addition to the above-mentioned essential components, the skin topical composition of the present invention contains other useful functions. In order to prevent and / or repair DNA damage, ingredients, whitening ingredients, anti-inflammatory ingredients, cooling agents, organic acids, anti-glycation ingredients, antibacterial ingredients, cell activation ingredients , astringent ingredients, antioxidant ingredients, anti-aging ingredients, moisturizing ingredients, polyhydric alcohol, keratin softening ingredients, amines, blood circulation promoting ingredients, sebum absorbing ingredients, peptides or their derivatives, amino acids or their derivatives Various components such as conductors may be blended in one or more combinations. As the above, those that can be used in the fields of medicines, quasi-drugs, cosmetics, etc. are particularly preferred. There is no limitation, and any one can be appropriately selected and used. If applicable, they may be added as ingredients for any of these functions.

[0072] Examples of the ultraviolet scattering agent include zinc oxide, titanium oxide, iron oxide, cerium oxide, Zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, hydrous silica Inorganic compounds such as acids, and their derivatives such as hydrous silicic acid, aluminum hydroxide, mica, It is coated with inorganic powder such as talc, or is made of polyamide, polyethylene, polyester, polystyrene, etc. Compounds of resin powder such as polyethylene and nylon, as well as silicone oil and fatty acid aluminum Examples include those treated with zinc salts, alkyl titanates, etc. Among these, zinc oxide, titanium oxide, etc. Inorganic compounds such as tungsten and iron oxide, and the combination of these inorganic compounds with aluminum hydroxide and hydrous silicate Preferably, the material is coated with inorganic powder such as mica or talc, or with silicone oil. When a component is blended, its content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001 to 35% by mass, preferably about The content is 0.1 to 25% by mass.

[0073] The ultraviolet absorbing agent is not limited, but is preferably a salicylic acid-based ultraviolet absorbing agent. agents, cinnamic acid-based UV absorbers, benzoylmethane-based UV absorbers, benzoic acid ester derivatives Body UV absorbers, triazine derivative UV absorbers, benzalmalonate derivative UV absorbers agents, octocrylene-based ultraviolet absorbers, imidazole sulfonic acid derivative ultraviolet absorbers, The ultraviolet absorber may be a zofenone derivative.

[0074] In detail, as the ultraviolet absorber, 2-ethylhexyl salicylate, homomene salicylate, salicylic acid-based ultraviolet absorbers such as ethylene glycol salicylate; Glyceryl cinnamate, mono-2-ethylhexanoate;para-dihydroxypropyl benzoate cinnamic acid-based ultraviolet absorbers such as 2-ethylhexyl or p-methoxycinnamate; 4-t Benzoylmethane UV absorbers such as ert-butyl-4'-methoxydibenzoylmethane 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, etc. Benzoic acid ester derivatives of ultraviolet absorbers; Dimethoxybenzylidene dioxoimidazolidine 2,2'-methylenebis[6-(2H-benzotriazoic acid ester; -yl-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol];2,4-bis- [{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl) phenyl)-1,3,5-triazine, diethylhexylbutamidotriazone, 2,4,6- Tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine triazine derivatives such as dimethicone diethyl benzalmalonate; Conductive ultraviolet absorber; 2-Cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester Octocrylene UV absorbers such as sterol; 2-phenylbenzimidazole-5-sulfonic acid , imidazole sulfones such as disodium phenyldibenzimidazole tetrasulfonate, Acid derivative UV absorber; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonic acid and its salts, dihydroxydimethoxybenzophenone Benzophenone, dihydroxybenzophenone, or tetrahydroxybenzophenone Examples of such ultraviolet absorbents include phenol derivative ultraviolet absorbents.

[0075] In the present invention, such an ultraviolet absorbing agent is, but not limited to, paramethoxyphenyl. 2-Ethylhexyl cinnamate, 4-tert-butyl-4'-methoxydibenzoyl meth 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester Dimethoxybenzylidene dioxoimidazolidinepropionic acid 2-ethylhexyl , 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1 ,3,3-tetramethylbutyl)phenol], 2,4-bis-[{4-(2-ethylhexyl) xyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1, 3,5-Triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl )Anilino]-1,3,5-triazine, dimethicone diethyl benzalmalonate, 2-cyclohexyl Ano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester, 2-phenyl Benzimidazole-5-sulfonic acid is preferred, and 2-ethyl paramethoxycinnamate is preferred. xyl, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-[4-(diphenyl 2,4-bis(2-hydroxybenzoyl)benzoic acid hexyl ester [{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methyl 2,4,6-Tris[4-(2-ethylphenyl)-1,3,5-triazine, [xyloxycarbonyl]anilino]-1,3,5-triazine, 2-phenylbenzoyl Midazole-5-sulfonic acid is more preferred, and 2-ethylhexyl paramethoxycinnamate is more preferred. , 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl 1,3,5-triazine, 2,4,6-tris[ 4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine is More preferred.

[0076] The ultraviolet absorbing agent may be a commercially available product or may be synthesized.

[0077] Commercially available products include, but are not limited to, Parsol EHS (DSM Nutrition Japan), ESCALOL 587 (Ashland Japan) , EusolexOS (Merck), Parsol HMS (DSM Nutrition (manufactured by BASF), Uvinul MC80 (manufactured by BASF), Parsol MCX (DSM Nutrition Japan), Parsol 1789 (DSM Nutrition Japan) (manufactured by SHON Japan), Ubinal A Plus Granular, Soft Shade D H, Tinosorb M (manufactured by BASF), Milestab 360, Mixxim BB / 100, Tinosorb S (BASF), Uvasorb HEB, Vinal T150 (manufactured by BASF), Heliosun OTZ (O'Laughli DSM Nutrition Industries), Parsol SLX (DSM Nutrition (manufactured by DSM Nutrition Japan), Parsol 340 (manufactured by DSM Nutrition Japan), Esca Roll 597 (Ashland Japan), Parsol HS (DSM Nutrition (manufactured by J.P. Japan), Eusolex232 (manufactured by Merk), NeoHeliopan AP (made by Herman & Reimer), Ubinal M40, Escarole 567 Ashland Japan Co., Ltd.), Ubinal MS40 (BASF), EESORB107 (Cipro) SEESORB100 (manufactured by Shipro Chemicals), SEESORB106 (manufactured by Shipro Chemicals) (manufactured by Seisakusho)

[0078] In the composition for external use on the skin of the present invention, the total content of the ultraviolet absorbing agent is , preferably 1 mass % or more, more preferably 3 mass % or more, and even more preferably 6 mass % or more. The total content of the ultraviolet absorbing agent is preferably 7% by mass or more, and more preferably 7% by mass or more. Preferably, the content is 20% by mass or less, more preferably 15% by mass or less, based on the total amount of the composition. More preferably, the total content of the ultraviolet absorbing agent is 10% by mass or less. Preferably, the content is 1 to 20% by mass, more preferably 3 to 15% by mass, and even more preferably The content is preferably 5 to 10% by mass, and particularly preferably 7 to 10% by mass.

[0079] In the skin topical composition of the present invention, the ratio of the total content of the ultraviolet absorber to the component (A) is not particularly limited, but the amount of the ultraviolet absorber is preferably 0 to 1 part by mass of the (A) component. 0.6 to 2 parts by weight, more preferably 1 to 2 parts by weight, and even more preferably 1.4 to 2 parts by weight It is.

[0080] In addition, these UV scattering agents and UV absorbing agents can be compounded, supported, or encapsulated with other components. The combination of these is not particularly limited.

[0081] Examples of components having an effect of preventing and / or repairing DNA damage include those for animals (e.g. , Artemia); components derived from plants (e.g., Cat's Claw); DN A, DNA salts, RNA, RNA salts, and other nucleic acid components. Prevention of DNA damage and / or The content of the ingredient having a repairing effect can be appropriately selected taking into consideration the feel and effect on the skin. However, the amount of the composition for external use on the skin of the present invention is, for example, about 0.001 to 3% by mass, preferably In general, the content is about 0.01 to 1% by mass. When animal or plant ingredients are used, the content is In terms of extracts such as dandelions, the amount is preferably about 0.0 The content is 0001 to 0.1% by mass, and more preferably about 0.0001 to 0.01% by mass.

[0082] Examples of whitening ingredients include placenta, arbutin, kojic acid, ellagic acid, and phytin. Acid; Tranexamic acid; Rucinol; Chamomilla ET; Hydroquinone, 4-Methoxysalicylic Acid potassium salt of linoleic acid; linoleic acid and its derivatives; ascorbic acid and its salts; ascorbic acid Vitamin C derivatives (sodium ascorbyl phosphate, sodium ascorbyl phosphate, Phosphate Magnesium, Tetra-2-hexyldecanoate Ascorbyl, 2-O-Ethyl Ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid glucoside, isostearyl Disodium Allyl Ascorbyl Phosphate, L-Ascorbyl Dipalmitate, Palmitic Acid Trisodium Ascorbyl Phosphate, Glyceryl Ascorbate, Bisglyceryl Ascorbate ascorbic acid, alkylglyceryl ascorbic acid, etc.), vitamin A or its derivatives, bread Vitamins such as beta-carotene and its derivatives are also included. Plant ingredients may be used as whitening ingredients. Examples of such plant ingredients include iris (Iris), Ardisia crenata (Ardisia crenata), and others. Mondo, aloe, acerola, oolong tea, star anise, Scutellaria, Coptis, Hypericum , Lamium, Seaweed, Cucumber, Gardenia, Sophora Root, Chlorella, Rice, Rice Moth, Lizanol, rice bran, rhizome, Japanese pepper, perilla, peony, cnidium, sophae Kuhi, soybean, natto, tea, angelica, calendula, witch hazel, safflower, peony leaf, Coix seed, Acacia oleracea, Diospyros kaki, kiwi, black bean, gentian, genus Gin, sage, radish, azalea, parsley, holly, hops, thyme, clove, chin Pisum sativum, Licorice, Chamomile, Prune, Meadowsweet, Purple bark, Sowberry, Gray Beans, pears, lemons, kiwis, pine, neem, artichokes, horsetail, olives Obaku, evening primrose, bilberry, geranium geranium, glasswort, white willow These include ingredients derived from saxifrage, centella asiatica, rosemary, lavender, and Chinese quince. When these plant ingredients are used in the skin topical composition of the present invention, the form of the plant ingredients is Although there is no particular limitation, it is usually used in the form of a plant extract or essential oil. The names in parentheses for the plant ingredients are the scientific name, alternative name, or herbal medicine name of the plant. It is. In the present invention, such a whitening component is not particularly limited, but may be, for example, placenta; Arbutin; Kojic Acid; Ellagic Acid; Phytic Acid; Tranexamic Acid; Rucinol; Chamomilla ET; Hydroquinone; 4-Methoxysalicylic acid potassium salt; Linoleic acid and its derivatives Ascorbic acid, sodium ascorbate, sodium ascorbyl phosphate Ascorbic acid phosphate magnesium, ascorbyl tetra 2-hexyldecanoate Ascorbic Acid, 2-O-Ethyl Ascorbic Acid, 3-O-Ethyl Ascorbic Acid, Ascorbic Acid Glucosides, Vitamin A oil; Iris, almond, aloe, acerola, radish, grass , coptis, St. John's wort, white lamb, seaweed, pueraria lobata, chlorella, rice, rice hawthorn Burrs, oryzanol, rice bran, perilla, peony, mulberry bark, soybean, tea, tokin Cinnamon, Hamamelis, Peony, Coix seed, Kiwi, Sage, Parsley, Holly, Hot , thyme, clove, chinpi, liquorice, chamomile, prune, meadowsweet, purple Japanese maple, Japanese laurel, grapefruit, thorn pear, lemon, kiwi, pine, neem, almond Artichoke, horsetail, barnyard millet, evening primrose, bilberry, geranium globulus, akke Perilla, white willow, saxifrage, centella, rosemary, lavender, sun Preferably, one or more extracts are selected from extracts extracted from Chinese quince, Placenta;Arbutin;Kojic Acid;Phytic Acid;Tranexamic Acid;Hydroquinone; Ascorbic Acid, Sodium Ascorbate, Sodium Ascorbyl Phosphate , Magnesium ascorbyl phosphate, Ascorbic acid tetra 2-hexyldecanoate Ascorbic acid, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, ascorbic acid glycerol Glucosides, Vitamin A Oil; Iris Root Extract, Almond Oil, Aloe Vera Extract, Acerola Extract, Ajitsu extract, Scutellaria root extract, Hypericum extract, Lamium extract, Seaweed extract, pueraria root extract, chamomile extract, peony root extract, mulberry bark extract, Soybean extract, tea extract, white tea extract, calendula, witch hazel, coix seed , Job's tears extract, Hop extract, Prune extract, Licorice extract, Oil-soluble Licorice Kisu, Meadowsweet Extract, Veronica Extract, Alpinia Katsumadai Seed Extract, Grapefruit extract, Rosa rosa extract, Lemon extract, Kiwi extract, Matsue extract , neem leaf extract, artichoke extract, horsetail extract, bark extract, Japanese pine Night primrose extract, evening primrose oil, bilberry leaf extract, geranium extract, glasswort extract One selected from the group consisting of white willow extract, centella asiatica extract, and Chinese cornus fruit extract More preferably, one or more species are used.

[0083] When the skin external composition of the present invention is blended with the above-described whitening ingredient, the content of the ingredient is The amount of the composition for external use on the skin can be appropriately selected taking into consideration the feel and effect on the skin. The concentration of the plant extract is about 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass. When using, the content is calculated as the extract, etc., based on the total amount of the skin topical composition. For example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, more preferably about 0.0001 to 20% by mass. More preferably, it is 0.001 to 10% by mass.

[0084] Anti-inflammatory ingredients include, for example, allantoin, calamine, tranexamic acid, and glycyrrhizin. glycyrrhizinic acid or its derivatives or their salts (e.g., dipotassium glycyrrhizinate, Monoammonium cyrrhizinate, etc.), glycyrrhetinic acid or its derivatives or Salts (e.g., glycyrrhetinic acid, stearyl glycyrrhetinate, etc.), zinc oxide, amine Nocaproic acid, azulene and its derivatives (e.g., guaiazulene, azulene, etc.), vinegar Tocopherol acid, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin cin, salicylic acid or its derivatives, steroids or their derivatives or their salts (e.g. For example, hydrocortisone, prednisolone), ufenamate, bufexamac, ibuprapone Lofenpiconol, glycol salicylate, botanicals (e.g., comfrey, coptis, douglas fir, Components derived from Houttuynia cordata, etc. are preferred. Allantoin, tranexamic acid , Dipotassium glycyrrhizinate, Monoammonium glycyrrhizinate, Glycyrrhetinic acid , stearyl glycyrrhetinate, aminocaproic acid, azulene and its derivatives, or dokuda and more preferably, allantoin, trametin, tetrahydrocanthus naphtha ... Choose from nexamic acid, dipotassium glycyrrhizinate, glycyrrhetinic acid, and aminocaproic acid. When anti-inflammatory ingredients are used, the content is determined based on the amount of the ingredient that is applied to the skin. The amount of the composition for external use on the skin of the present invention can be appropriately selected in consideration of the feeling of use and the effect. For example, the content is about 0.0003 to 10% by mass, and preferably about 0.01 to 5% by mass.

[0085] Examples of antibacterial ingredients include chlorhexidine, salicylic acid, benzalkonium chloride, Acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives Body, povidone-iodine, potassium iodide, iodine, isopropyl methylphenol, trichloroethylene Rocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol Tanol, alkyldiaminoglycine hydrochloride, cetylpyridinium chloride, piroctoolamine , miconazole or its salt, chlorobutanol, ethylhexylglycerin, butyl Propynyl iodide carbamate, caprylhydroxamic acid, phenethyl alcohol, methyl Leuisothiazolinone, sorbic acid, β-glycyrrhetinic acid, plants (e.g., Sophora flavescens, Rhododendron amplexicaule) Examples of the components include those derived from mulberry, eucalyptus, etc. Acid, benzalkonium chloride, ethanol, benzethonium chloride, gluconic acid, isopropyl methylphenol, paraben, phenoxyethanol, cetylpyridinium chloride, chlorine Butanol, Ethylhexylglycerin, Iodopropynyl Butylcarbamate, Caprylic / Capric Triglyceride One or more selected from the group consisting of arylhydroxamic acid, sorbic acid, and β-glycyrrhetinic acid When an antibacterial ingredient is added, its content should be determined taking into consideration the feel on the skin and the effect. The amount can be appropriately selected, but may be, for example, about 0.0003 to ...4 relative to the total amount of the composition for external use on skin of the present invention. The content is 10% by mass, and preferably about 0.01 to 5% by mass.

[0086] Examples of the cooling agent include menthol and its derivatives, camphor, borneol, and gelatin. Terpenes such as raniol, cineole, anethole, limonene, and eugenol (these may be in the d-, l- or dl-form; eucalyptus oil, bergamot oil, peppermint oil Mint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose Among them, l-menthol, menthyl glyceryl ether, and essential oils such as turpentine oil are particularly preferred. Menthyl lactate, menthyl 3-hydroxybutyrate, menthoxypropanediol Combinations with oleic acid, camphor, eucalyptus oil, peppermint oil, and peppermint oil are preferred.

[0087] Examples of organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, chlorine, and glycerol. Enic acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propyl acetic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, bread acid Tothenic acid, glycyrrhetinic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, Examples of the salts include sulfuric acid, azelaic acid, and salts thereof. salts of mineral acids such as acid or phosphoric acid; salts of organic acids such as maleic acid or methanesulfonic acid; Alkaline metal salts such as potassium or alkaline earth metal salts, ammonium salts, basic amine salts, etc. Among these, gluconic acid, chlorinated isopropyl alcohol, and amine salts such as triethanolamine. Enic acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytic acid, A combination of one or more selected from tartaric acid, lactic acid, glycyrrhetinic acid and their salts A combination is more preferable.

[0088] Examples of anti-glycation ingredients include Budreja axillaris leaf extract, plum fruit extract, and E. -Delweiss extract and other plant extracts, evening primrose oil, amla fruit, fruit juice or their extracts L-arginine, L-lysine, hydrolyzed casein, hydrolyzed tannins, carnosine etc.

[0089] Examples of cell activating components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid. Acids: Retinol, thiamine, riboflavin, pyridoxine hydrochloride, pyrroloxacin, pantothenate Vitamins such as quinones; gluconic acid, phytic acid, glycolic acid, lactic acid, etc. α-hydroxy acids; tannins, flavonoids, saponins, allantoin, photosensitizer No. 301, Components derived from plants (for example, soybean sprouts, bilberry leaves, etc.) etc. When adding activating ingredients, the amount of the ingredient can be selected appropriately taking into consideration the feel and effect on the skin. However, for example, about 0.0003 to 10% by mass based on the total amount of the skin external composition of the present invention. , and preferably about 0.001 to 5 mass %.

[0090] Examples of astringent ingredients include alum, chlorohydroxyaluminum, and aluminum chloride. nium, aluminum allantoin, zinc paraphenolsulfonate, basic aluminum lactate Metal salts such as aluminum zinc, zinc sulfate, and potassium aluminum sulfate; tannic acid, citric acid Examples of organic acids that can be used include lactic acid, succinic acid, etc. The amount of the composition for external use on the skin of the present invention can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.0003 to 20 mass%, preferably about 0.01 to 10 mass%, based on the total amount. Quantity %.

[0091] Examples of the antioxidant include butyl hydroxyanisole and dibutyl hydroxytoluene. Ene, sodium hydrogen sulfite, sodium pyrosulfite, erythorbic acid and its salts, aspartame Corbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, Glutathione-S-transferase, catalase, superoxide dismutase, Thioredoxin, taurine, thiotaurine, hypotaurine, plant extract (honeysuckle flower extract) When antioxidants are used, their content is determined based on the sensation of use on the skin. The amount of the external skin composition of the present invention may be appropriately selected taking into consideration the effect and the amount of the external skin composition. .00001 to 10% by mass, preferably about 0.0001 to 5% by mass, more preferably 0. The content is 0.01 to 5 mass %.

[0092] Anti-aging ingredients include, for example, hydrolyzed soy protein, retinoids (retinol, tinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingomyelin Syn derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, peptides (Caprooyl tetrapeptide-3, oligopeptide-24, etc.) Hydrolyzed soy protein, retinol, retinol acetate, retinol palmitate, calcium carbonate Prooyl tetrapeptide-3 and oligopeptide-24 are preferred. Contains anti-aging ingredients When the composition is used, the content can be appropriately selected taking into consideration the feel on the skin and the effect of the composition. For example, about 0.0003 to 10% by mass, preferably about The content is 0.01 to 5% by mass.

[0093] Moisturizing ingredients include, for example, alanine, serine, aspartic acid, glycine, and proline. , hydroxyproline, glucosamine, theanine, arginine, and other amino acids and their derivatives Conductors; polyhydric alcohols such as glycerin and 1,3-butanediol; sorbitol, xylitol Lithritol, erythritol, maltose-sucrose condensates (gluco-oligosaccharides), glyceryl Sugar alcohols such as glucosides; glycosyltrehalose, trehalose; ceramides, glucosides, etc. Glucosylceramide, cholesterol, phytosterol, cholesterol derivatives, phytosterol Sterol derivatives; phospholipids such as lecithin and hydrogenated lecithin; lactic acid, sodium lactate , sodium pyrrolidone carboxylate, urea and other NMF-derived components; collagen, elastin keratin, chitin, chitosan, etc. and their hydrolysates; hydroxyethyl urea; (e.g. chamomile, hamamelis, tea, perilla, grapefruit, gynostemma etc.) Among them, glycine, arginine, glycerin, 1 ,3-butanediol, glycosyltrehalose, ceramide, glucosylceramide, chole Sterols, cholesterol derivatives, phytosterol derivatives, hydrogenated lecithin, lactic acid , Sodium Lactate, Sodium Pyrrolidone Carboxylate, Urea, Collagen, Elastin It is preferable to use a combination of one or more selected from the group consisting of keratin and hydroxyethyl urea. When moisturizing ingredients are added, their content should be appropriately determined taking into consideration the feel and effect on the skin. However, the amount of the external skin composition of the present invention may be selected from the range of about 0.001 to 20 mass %. % by mass, preferably about 0.01 to 10% by mass.

[0094] The polyhydric alcohols include diols having 2 to 4 or 11 or more carbon atoms, and polyols having 3 or more hydroxyl groups. Examples of suitable polyhydric alcohols include glycerin, diglycerin, triglycerin, and the like. Serine, propylene glycol, 1,3-butanediol, ethylene glycol, diethylene Examples of suitable olefin glycol include ethylene glycol, isoprene glycol, and 1,3-butylene glycol. Among them are glycerin, diglycerin, propylene glycol, and 1,3-butylene glycol. It is preferable to use a combination of one or more selected from the following. In this case, the content can be appropriately selected taking into consideration the feel on the skin and the moisturizing effect. For example, about 0.1 to 20% by mass, preferably about 0.5 to 10% by mass, based on the total amount of the composition for external use on the skin. It is 15% by mass.

[0095] Examples of keratin softening ingredients include lanolin, urea, phytic acid, lactic acid, lactate, and glycosaminoglycans. Acid, salicylic acid, malic acid, citric acid, fruit acid, phytic acid, urea, sulfur, etc. Among them, lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid, A combination with citric acid is preferred. When a keratin softening ingredient is added, its content should be adjusted according to the amount of the ingredient applied to the skin. can be appropriately selected taking into consideration the feel and effect of use, For example, 0.0001 to 50% by mass, preferably about 0.001 to 50% by mass, more preferably Or, it is about 0.01 to 25% by mass.

[0096] Vitamins include, for example, retinol, retinol acetate, and retinol palmitate. , retinol derivatives such as retinol propionate and retinol linoleate, retinal, Retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d -δ-tocopheryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate Vitamin A derivatives such as thiocyanate; β-carotene, α-carotene, γ-carotene, δ-carotene Provitamin A, such as lycopene, zeaxanthin, cryptoxanthin, and echinenone dl-α-tocopherol, dl-α-tocopherol succinate, dl-α- Calcium tocopherol, delta-tocopherol, tocopherol nicotinate, dl acetate -α-Tocopherol, Tocopherol Linoleate, Tocopherol (Linoleic Acid / Oleic Acid) Vitamin E such as ascorbyl / tocopheryl phosphate potassium; riboflavin flavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate Esters, Riboflavin tetrabutyrate, Riboflavin 5'-phosphate sodium Vitamin B2 such as riboflavin tetranicotinate; methyl nicotinate; Nicotinic acid, benzyl nicotinate, and other nicotinic acids other than the above component (A); stearyl Ascorbyl phosphate, disodium isostearyl ascorbyl phosphate, L dipalmitate -Ascorbyl, tetraisopalmitate (tetra 2-hexyldecanoate scorbyl), trisodium ascorbyl palmitate phosphate, ascorbic acid, ascorbic acid Sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate Ascorbyl phosphate magnesium, ascorbyl glucoside, 2-O- Ethyl ascorbic acid, 3-O-ethyl ascorbic acid, glyceryl ascorbic acid, bi Vitamin C such as glyceryl ascorbic acid, alkylglyceryl ascorbic acid, etc. Vitamins such as methylhesperidin, ergocalciferol, and cholecalciferol D group; Vitamin K group such as phylloquinone, falnoquinone; thiamine and their salts (e.g. For example, dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine diphosphate, etc. Pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-phosphate Vitamin B6 such as pyridoxal, pyridoxamine hydrochloride, cyanocobalamin, Vitamin B12 such as socobalamin and deoxyadenosylcobalamin; folic acid, pteroyl Glutamic acid and other folic acids; pantothenic acid, calcium pantothenate, pantothenyl alcohol Panthenol, D-pantetheine, D-pantethin, coenzyme A, pantothenyl ester pantothenic acids such as calcium pantetheine sulfonate; biotin, biotin, Biotins such as cytin; carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, hesperidin and glucosylherperidin, Vitamin-like factors such as ubiquinone and their salts are also included. Combinations with vitamin B, vitamin C, vitamin E, vitamin A, and vitamin-like factors are preferred, particularly pyridoxine hydrochloride, pantothenyl alcohol (panthenol), lyvof Rabin, cyanocobalamin, ascorbic acid, ascorbic acid glucoside, 3-O-ethyl Ascorbic acid, sodium ascorbyl phosphate, ascorbyl phosphate Magnesium ester, dl-α-tocopherol acetate, ascorbyl palmitate Tetrahexyl Ascorbyl Tetrahydrocanthate, Retinol, Retinol Palmitate , retinol propionate, retinol acetate, pyrroloquinoline quinone or its salt, ubiquitin A combination with one or more selected from non-oryzanol and γ-oryzanol is more preferred. When adding vitamins, the amount should be selected appropriately, taking into consideration the skin feel and effects. However, the amount of the composition for external use on skin of the present invention may be, for example, about 0.001 to 30% by mass, Preferably, it is about 0.01 to 25% by mass, more preferably about 0.01 to 20% by mass. .

[0097] Examples of blood circulation promoting ingredients include plants (e.g., ginseng, angelica tree, arnica, etc.) , ginkgo, fennel, laurel, Dutch oak, chamomile, Roman chamomile, Rotthorn, gentian, burdock, rice, hawthorn, shiitake mushroom, European hawthorn, European hawthorn Juniper, Cnidium, Swertia japonica, Thyme, Clove, Chinese ginger, Angelica acutiloba, Peach tree, Spruce, Carrot, garlic, butcher's broom, grape, peony, horse chestnut, melissa, yuzu , coix seed, rosemary, rose hips, tangerine, angelica tree, spruce, peach, apricot, Ingredients derived from walnuts and corn; dl-α-tocopherol acetate, nicotinic acid triglyceride These include copherol, glucosyl hesperidin, and hesperidin. When the composition is mixed with the skin, the content of the composition can be appropriately selected in consideration of the feel and effect on the skin. For example, about 0.00001 to 10% by mass, preferably about 0.00001 to 10% by mass, based on the total amount of the composition for external use on skin. The content is preferably 0.0001 to 5% by mass, and more preferably about 0.001 to 5% by mass. When ingredients are used, the content is calculated as an extract, etc., relative to the total amount of the topical skin composition. For example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass. and more preferably, 0.001 to 10% by mass.

[0098] Examples of sebum-absorbing components include talc, mica, hydroxyapatite, zinc oxide, Among them, mica, hydroxyapatite, and the like are preferable. In the case where a sebum-absorbing component is blended, the preferred is mica. In this case, the content can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001 to 35% by mass, preferably about 0.1 to 35% by mass, based on the total amount of the composition. It is 25% by mass.

[0099] Examples of peptides or derivatives thereof include keratin decomposition peptides and hydrolyzed keratin. , collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, Gelatin, elastin, elastin decomposition peptides, collagen decomposition peptides, hydrolyzed collagen collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed pe Peptide, conchiolin hydrolyzed peptide, hydrolyzed conchiolin, silk protein hydrolyzed peptide, Hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein hydrolyzed peptide, dehydrated Soy protein, wheat protein, wheat proteolysis peptides, hydrolyzed wheat protein, casein hydrolysis peptides , acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl lumitoyl tetrapeptide, etc.) Keratin, fish-derived collagen elastin, elastin decomposition peptide, collagen decomposition peptide Tide, hydrolyzed collagen, succinylated atelocollagen, elastin hydrolysis peptide, One or two selected from hydrolyzed silk, soy protein hydrolyzed peptide, and hydrolyzed soy protein The combination of the above is more preferable. When a peptide or its derivative is blended, the content The amount of the composition for external use on the skin of the present invention can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.0001 to 35 mass%, preferably about 0.001 to 10 mass%, Quantity %.

[0100] Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, , hydroxyproline, arginine, lysine, serine, glycine, alanine, phenyl Alanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartate Paragic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, hyaluronic acid Styridine, threonine, tyrosine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid Butyric acid, carnitine, carnosine, creatine, epsilon aminocaproic acid, triphosphatidylcholine, Tophan, Ornithine, Sodium N-Stearoyl-L-Glutamate, Dilaurami Lysine glutamate and its salts, di(phytosteryl / octyl) lauroyl glutamate dodecyl), di(octyldodecyl / phytosteryl / behenyl) lauroyl glutamate In addition, these amino acids or derivatives thereof may be in the form of solvates such as hydrates. The amino acid may be in the d-form, the l-form, or the dl-form. One or more selected from derivatives are preferred.

[0101] In addition to the above-mentioned components, the skin topical composition of the present invention may further contain the following components depending on its application or formulation: Ingredients that are commonly used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc. may be appropriately blended. The ingredients that can be added are not particularly limited, but may be, for example, a base or carrier, a surfactant, etc. , thickener, antioxidant, preservative, pH adjuster, chelating agent, stabilizer, irritation reducer Additives such as coloring agents, dispersants, and fragrances can be added. They can be used alone or in any combination of two or more. The amount can be appropriately determined from the conventionally known range without impairing the effects of the present invention. In addition, if the following components are applicable to multiple components, they may be used as components with any of the following functions. It can be added as follows.

[0102] The base or carrier may be an aqueous base such as water; liquid paraffin, liquid isoparaffin, or sucrose. Quaran, Vaseline, Paraffin, Microcrystalline Wax, Polybutene, Polyethylene Ethylene powder, gelling hydrocarbons (Plastibase, etc.), ozokerite, α-olefin oligomer Hydrocarbons such as methyl polysiloxane, light liquid paraffin, and light iso-liquid paraffin; Methylpolysiloxane, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, methylphenyl Phenyl-modified silicones such as polysiloxanes, cyclic silicones such as decamethylcyclopentasiloxane, etc. Silicone, methyl hydrogen polysiloxane, methyl trimethicone, dimethicone Alkyl-modified silicones such as dimethiconol crosspolymer and caprylyl methicone , crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone , polyglycerin modified silicone, cross-linked polyether modified silicone, cross-linked alkyl Polyether modified silicone, silicone / alkyl chain co-modified polyether modified silicone Silicone / alkyl chain co-modified polyglycerin modified silicone, polyether modified molecular weight Branched silicone, polyglycerin modified branched silicone, acrylic silicone, phenyl modified silicone Silicone oils such as silicone resins; cetanol, cetostearyl alcohol Alcohol, Stearyl Alcohol, Behenyl Alcohol, Octyldodecanol, Isostearate higher alcohols such as aryl alcohol, phytosterols, and cholesterol; isostearyl alcohols such as ethyl alcohol, phytosterols, and cholesterol; Acids such as arylene, lauric, myristic, palmitic, stearic, and behenic acids Higher fatty acids such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl Cellulose derivatives such as methyl cellulose; polyvinylpyrrolidone; polyvinylbromine Polyethylene glycol; Dioxane; Butylene glycol adipate Polyethylene glycol Ster; Isopropyl myristate, octyldodecyl myristate, iso palmitate Propyl, cetyl palmitate, isononyl isononanoate, diisopropyl adipate, Decyl oleate, isodecyl oleate, hexyldecyl dimethyloctanoate, sebacillus acid Diisopropyl Phosphate, Di-2-ethylhexyl Sebacate, 2-Hexyl Myristate 2-Hexyldecyl Palmitate, Diisopropyl Adipate, Isononanoic Acid Iso Tridecyl, cetyl lactate, isostearyl isostearate, 12-hydroxystearyl Cholesteryl stearate, cholesteryl oleate, macadamia Fatty acid phytosteryl, oleic acid phytosteryl, palmitic acid dextrin, Inulin Thearate, Hydrogenated Jojoba Oil, Ethylene Glycol Di-2-Ethylhexyl , dipentaerythritol fatty acid ester, neopentyl glycol dicaprate, tri Tri-2-ethylhexyl mellitic acid, Tritridecyl trimellitic acid, Tri-2-ethylhexyl Trimethylolpropane silylates, Trimethylolpropane triisostearate, Tetra -Pentaerythritol 2-ethylhexanoate, Glycerin tri-2-ethylhexanoate , Trimethylolpropane Triisostearate, Tri(caprylic / capric)glycerin Ceryl, Tri(Caprylic / Capric / Myristic / Stearic)Glyceryl, O Oleyl leate, di(phytosteryl / octyldodecyl) lauroyl glutamate, Lauroyl glutamate di(octyldodecyl / phytosteryl / behenyl), citric acid Triethyl, Dimer Dilinoleate (Phytosteryl / Isostearyl / Cetyl / Stearic Acid (aryl / behenyl), dimer dilinoleyl dimer dilinoleate, tripolyhydroxys Dipentaerythrityl stearate, tri(behenic acid / isostearic acid / eicosanedioic acid) glycol Esters such as lyceryl; jojoba oil, meadow wax, candelilla wax, rice bran wax, Waxes such as cotton wax, carnauba wax, and lanolin; avocado oil, linseed oil, camellia oil, and maca Demia nut oil, Kukui nut oil, Hazelnut oil, Corn oil, Olive oil, Sa Flower oil, apricot kernel oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, aloe vera oil Indian oil, shea butter, camellia oil, rapeseed oil, sesame oil, cocoa butter, coconut oil, hardened coconut oil, parsley oil, Palm oil, palm kernel oil, Japanese laurel kernel oil, Japanese laurel, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil , soybean oil, peanut oil, tea seed oil, evening primrose oil, shea butter, and other oils and fats; dextrin, maltodextrin Polysaccharides such as thorin; carboxyvinyl polymers, alkyl-modified carboxyvinyl poly Vinyl polymers such as mers; lower alcohols such as ethanol and isopropanol; sugar alcohols such as ruthenium, xylitol, erythritol, mannitol; water, etc. The base or carrier selected from these components may be used alone. Two or more of them may be used in combination. The amounts of them used are appropriately selected from the ranges known to those skilled in the art. When the composition for external use on the skin of the present invention contains water, the content of water is the same as that of the cosmetic composition. The amount of the external skin composition of the present invention may vary depending on the form of the composition, and is not particularly limited. For example, the amount of water is preferably 5 to 99% by mass, more preferably 8 to 95% by mass, and further The content is preferably 10 to 90% by mass.

[0103] Examples of surfactants include sorbitan monoisostearate, sorbitan monostearate, Diglycerol sorbitan tetra-2-ethylhexyl ester, sorbitan monophosphate oleate, sorbitan monoisostearate and sorbitan monolaurate, olive oil Sorbitan fatty acid esters such as sorbitan fatty acid; polyoxyethylene monolaurate ( 20) Sorbitan, Polyoxyethylene Monolaurate (80) Sorbitan, Monostearate Polyoxyethylene (20) Sorbitan Phosphate, Polyoxyethylene (2 (0) Sorbitan, polyoxyethylene isostearate, etc. (20) Sorbitan, etc. Diethylene sorbitan fatty acid ester; glycerin monooleate, glycerin monoester glycerol fatty acid esters such as glycerol monomyristate and glycerol monomyristate; Glycerin alkyl groups such as tearyl glyceryl ether and monomyristyl glyceryl ether Diglyceryl ether; diglyceryl monostearate, decaglyceryl decastearate, decaglyceryl Polyglycerides such as lyceryl decaisostearate and diglyceryl diisostearate fatty acid esters; propylene glycol fats such as propylene glycol monostearate Fatty acid esters; Polyoxyethylene hydrogenated castor oil 40, Polyoxyethylene hydrogenated castor oil Oil 50, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 80, etc. hydrogenated castor oil derivatives; polyoxyethylene monococoyl glyceryl fatty acid and other polyoxyethylene Ethylene glycerol fatty acid ester; Polyoxyethylene (20) phytosterol, poly Polyoxyethylene (30) Phytosterol, Polyoxyethylene (25) Phytostano Polyoxyethylene sterols such as polyoxyethylene (30) cholestanol, polyoxyethylene (30) cholestanol, etc. Hydrogenated sterols; sucrose fatty acid esters; polyoxyalkylene alkyl (or alkenyl) N-Acyl) ether sulfate, ether carboxylate, alkyl phosphate, Amino acid salts, acylated taurates; amines such as stearylamine and oleylamine Polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxane Polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, etc. Silicone surfactants or lecithin, hydrogenated lecithin, saponin, surfactin Examples of surfactants include naturally occurring surfactants such as sodium phosphate, cholesterol, and bile acids. can.

[0104] Examples of thickeners include polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl Vinyl thickeners such as methyl ether, carboxyvinyl polymer, methyl cellulose, etc. cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxy Hydroxypropyl cellulose, Hydroxypropyl methylcellulose, Carboxymethyl cellulose cellulose-based thickeners such as cellulose, carboxyethyl cellulose, guar gum, sclerotium Mugum, tamarind gum, xanthan gum, gellan gum, dextran, pectin, Lulan, gelatin, locust bean gum, carrageenan, agar, methacrylic acid Alkyl polyacrylate copolymer, sodium polyacrylate, bentonite, dextrin fatty acid ester Stel, Dimethyl Distearyl Ammonium Hectorite, Sodium Alginate, Al Propylene glycol ester of glyceryl ester, polyethylene glycol, macrogol, (Ac Hydroxyethyl acrylate / Na acryloyldimethyl taurate copolymer, (acryloyl Examples of the copolymer include ammonium dimethyl taurate / vinylpyrrolidone copolymer. However, xanthan gum, acrylic acid alkyl methacrylate copolymer, hydroxyethyl cellulose cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, calcium Polyoxyvinyl polymer, Dimethyl distearyl ammonium hectorite, (acrylic acid Hydroxyethyl / Sodium Acryloyldimethyl Taurate Copolymer, (Acryloyl Dimethyl Taurate) Ammonium methyl taurate / vinyl pyrrolidone copolymer is preferred.

[0105] Examples of the antioxidant include dibutylhydroxytoluene and butylhydroxyanisole. ethanol, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivatives, tocopherol Erythorbic acid, sodium erythorbate, L-cysteine, tocopherol derivatives Stains hydrochloride, ubiquinones such as coenzyme Q10, lignans such as sesamin, curcumin Min, capsaicin, gingerol, resveratrol, anthocyanin, cyanidin, Examples include bilberry extract and its analogs or derivatives.

[0106] Preservatives or antiseptics include, for example, benzoic acid, sodium benzoate, dehydroacetic acid, Sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate Pill, Butyl Parahydroxybenzoate, Ethyl Parahydroxybenzoate, Propyl Parahydroxybenzoate Pill, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol , benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorgluconate Hexidine, methylisothiazolinone, iodide propynyl butylcarbamate, capryl Hydroxamic acid, phenethyl alcohol, ethylhexylglycerin, capric glycerin Examples of preservatives include methylphenol, isopropyl methylphenol, etc. The content of the ingredient can be appropriately selected taking into consideration the feel and effect on the skin. For example, about 0.001% by mass to 5% by mass, preferably about 0.01% by mass, based on the total amount of the composition. ~1% by mass.

[0107] Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, etc.), and citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), organic bases (triethanolamine, diisopropyl propanolamine, triisopropanolamine, etc.

[0108] Examples of chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediamine Disodium edetate (Japanese Pharmacopoeia, EDTA-2Na, etc.) , potassium salts, etc.), phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid, etc. Of these, sodium edetate is preferred.

[0109] Examples of the stabilizer include sodium polyacrylate and dibutylhydroxytoluene. , butyl hydroxyanisole, and the like.

[0110] Examples of irritation reducers include licorice extract, gum arabic, polyvinylpyrrolidone, etc. Some examples include:

[0111] [pH] The composition for external application to the skin of the present invention may generally have a physical property of pH 2.0 to 9.0. From the viewpoint of low irritation to the skin and mucous membranes and good skin feel, the pH is preferably 3. 0 to 8.5, more preferably pH 4.0 to 8.0, and even more preferably pH 4.5 to 7.5, and even more preferably, the pH is 5.0 to 7.5.

[0112] [Method of manufacturing the composition for external use on skin] The method for producing the composition for external use on the skin of the present invention is not particularly limited, and in addition to the above-mentioned components (A) to (C), The other ingredients mentioned above are appropriately selected and mixed, and emulsified as necessary in a conventional manner to produce the product. It can be constructed.

[0113] [Properties / Formulation] The form of the composition for external use on the skin of the present invention is not particularly limited, and may be liquid, fluid, or semi-solid. The formulation may be, for example, a liquid, a suspension, an emulsion, a cream, Milky lotion, ointment, gel, liniment, lotion, aerosol, non-woven fabric containing medicinal liquid It can be formulated as a sheet or mist soaked in water. Among others, it is used as an emulsion or cream. Suitable formulations include creams, emulsions, ointments, gels, lotions, and sheets. In particular, emulsions, creams, ointments, and other similar preparations are suitable. In the case where the composition contains an oily base and an aqueous base, it may be of the W / O type or the O / W type. From the viewpoint of ensuring the appropriate thickening of the skin topical composition and the feeling of use (stickiness, spreadability, moisturizing From the standpoint of taste, etc., O / W type is more preferable.

[0114] [Usage] Specific uses of the composition for external use as a quasi-drug or cosmetic include, for example: Lotion, milky lotion, gel, cream, serum, sunscreen, pack, mask, Such as Ruin One Gel, Hand Cream, Body Lotion, and Body Cream Basic cosmetics; as well as facial cleansers, hand soaps, makeup removers, body shampoos, shampoos Cleansing cosmetics such as washes, rinses, and treatments, foundations, and makeup bases Face makeup cosmetics, lip balm, lip liner, lip gel, etc. lip cosmetics; hair rinses, hair treatments, hair conditioners, hair Hair products such as hair gel, hair mousse, hair mist, hair lotion, styling products Among these, compositions for external use on the skin are particularly preferred. The composition for external use of the present invention is a composition for external use on the skin for use as a medicine, a quasi-drug, or a cosmetic. The formulation of the skin external composition is the same as that of the skin external composition of the present invention. The bases or carriers, additives, and active ingredients that can be used, as well as preferred ones thereof, are described in the present specification. The same applies to the topical composition of the invention.

[0115] [container] The skin topical composition of the present invention is packed in a container of a shape and material appropriately selected according to the purpose and application of the composition. Specific examples of containers include spray types, bottles, etc. Toll type, tube type, jar type, dropper type, dispenser type, Examples of the composition for external application to the skin of the present invention include a stick type, a pouch bag, and a cheer pack. The color of the container and the transparency of the container are improved from the viewpoint of appearance due to the effect of the present invention in which coloring is suppressed. This allows for greater freedom in designing the shape and design of the product. For example, coloring over time can be achieved. For compositions that can be seen, the choice of opaque containers and container colors that correspond to the degree and color of coloring are available. Therefore, in the skin topical composition of the present invention, for example, a transparent container, a white container, etc. It is possible to select a container color that can be avoided in the case of a composition that shows coloring due to the transparency. The bright container includes both a colorless transparent container and a colored transparent container. The composition has a gelatinous finish that is easily visible over a wide area due to the effect of the present invention in which coloring is suppressed. It can also be preferably used in container dosage forms such as capsule types.

[0116] The container materials are polyethylene terephthalate, polypropylene, polyethylene Polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin Examples of the material include plastic, polystyrene, glass, and metal (aluminum, etc.). The materials are coated with various coatings, taking into consideration strength, flexibility, weather resistance, and stability of the ingredients. These materials can be combined, for example by mixing, or laminated to form containers. The coating material can be epoxy resin, polyamide, etc. Among them, polypropylene, polyethylene (HDPE, LDP Ethylene vinyl alcohol resin, metal (aluminum, etc.) can be used. preferable.

[0117] [How to use etc.] The skin topical composition of the present invention is expected to have the physiological activity of nicotinamide, and is effective in promoting blood circulation and preventing inflammation. It can also be used for whitening, anti-wrinkle, anti-aging, and other skin-care purposes. It is expected to have a skin-whitening effect and is useful as a multi-functional formulation, including as a skin-whitening agent and sunscreen. The skin topical composition of the present invention can be administered once or several times a day depending on the intended use. It can be used in known or customary manner and dosage.

[0118] [Coloring suppression method] In another embodiment, the present invention relates to a method for applying a composition for external use on the skin comprising (A) nicotinamide. It is also possible to provide a method for suppressing color. (A) Nicotinamide; (B) Hyaluronic Acid , its derivatives, their salts, and heparinoids. and (C) an amphiphilic compound, In the above method, the coloring of the composition can be suppressed. Other optional ingredients, properties, dosage form, uses, etc. of the composition are as described above.

[0119] As used herein, the term "coloring" refers to, for example, the form in which the composition for external use on the skin of the present invention is If there is any difference, it refers to a color change that can be detected by instruments such as a color difference meter and an absorptiometer. However, coloring that is difficult to detect by the naked eye is also considered to be coloring here. For example, when the composition for external use on the skin of the present invention is prepared as an aqueous composition, it is colorless and transparent. However, accelerated tests for thermal stability have shown that the color turns yellow over time. Controlling refers to preventing, retarding, and reducing such coloration. In this specification, the term "suppression of coloring" refers to a comparison of a composition containing the same concentrations of components (A) and (B). The coloration resulting from the change over time of the composition containing the components (A) to (C) was measured using a color difference meter ( (manufactured by Nika Minolta) and * The change in value, i.e., Δb * By comparing the values, This refers to improving the degree of discoloration to a detectable level.

[0120] In another embodiment, but not limited to, (A) nicotinic acid amide 5% by weight or more; B) From the group consisting of hyaluronic acid, its derivatives, their salts, and heparinoids. and (C) an amphiphilic compound. In the examples described later, 5% by mass or more of nicotinic acid amide as component (A) is used. When mixing, even if there is only one type of component (B) present, coloring may occur. In this case, a problem different from the above has been found. It is preferable that cetylated hyaluronic acid and / or its salt is contained. C) It is possible to suppress coloring by using an amphiphilic compound. Ingredients (B), (C) and other optional ingredients that can be included, their contents, properties, and agents The type, use, etc. are as described above for the composition. EXAMPLES

[0121] The present invention will now be described in detail with reference to examples, but the present invention is not limited to the following examples. It's not something like that.

[0122] The components used in the examples are as follows. The values ​​in each table correspond to the component names. This is the content of the ingredient itself.

[0123] Polyoxyethylene methyl glucoside: Macbiobride MG-10E (NOF Corporation) (Manufacturer) Polyoxypropylene methyl glucoside (10P.O.): Macbiobride MG-1 0P (NOF Corporation) Polyoxyethylene polyoxypropylene butyl ether (17E.O.) (17P. O.): Unilube 50MB-26 (manufactured by NOF Corporation) Polyoxyethylene polyoxypropylene glyceryl ether (24E.O.) (24 PO): Unilube 50TG-32 (manufactured by NOF Corporation) Polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside: Lubride MG2070 (manufactured by NOF Corporation) Polyoxybutylene Polyoxyethylene Polyoxypropylene Glyceryl Ether (3 BO)(8E.O)(5P.O): Wilbride S-753 (manufactured by NOF Corporation) Polyoxypropylene diglyceryl ether: SY-DP14 (Sakamoto Pharmaceutical Co., Ltd. (Manufacturer) Polyoxyethylene polyoxypropylene glycol (19E.O.) (21P.O. ): Pronon #124P (manufactured by NOF Corporation) Polyoxyethylene polyoxypropylene glycol (26E.O.) (30P.O. ): Pronon #184R (manufactured by NOF Corporation) Bisethoxydiglycol cyclohexanedicarboxylate: Neosolue aqul io (manufactured by Nippon Fine Chemical Co., Ltd.) Decaglyceryl (eicosandioate / tetradecanedioate): Neosolue-Aqua S (manufactured by Nippon Fine Chemical Co., Ltd.) 2-Methacryloyloxyethyl phosphorylcholine-Butyl methacrylate copolymer:L ipidure-PMB(BG) (NOF Corporation) Polyoxyethylene polyoxypropylene decyl tetradecyl ether (24E.O) (13P.O): Solbure GS-01 (manufactured by NOF Corporation) Polyoxypropylene sorbitol (25P.O.): Uniol HS-1600D (Japan (manufactured by Yuyu Co., Ltd.)

[0124] [Test Example 1 Thermal Stability Test] A sample was prepared by mixing various components according to the compositions shown in Tables 1 to 3 below in a conventional manner, and then The sample was placed in a 20 mL glass vial and incubated in a thermostatic chamber set at 60°C for one week. After one week, the changes in color (changes in appearance and color difference) were evaluated visually and with a spectrophotometer. did.

[0125] (Evaluation method) The evaluation criteria for the change in color and appearance were as follows: Each sample was packed in a transparent glass vial and stored in a constant temperature bath at 4°C for one week. The samples were stored in a constant temperature bath at 60°C for one week (accelerated test), and then visually inspected to see if they were worn. The difference in color was judged.

[0126] (Visual coloring criteria) ◎ No change Almost no coloring × Colored

[0127] A more detailed method for evaluating color difference using a spectrophotometer is as follows. Each sample was packed in a transparent glass vial and stored in a constant temperature bath at 4°C for one week. The samples were stored in a constant temperature bath at 60°C for one week (accelerated test) and then measured with a color difference meter ( Measurements were taken using a CM3500d (manufactured by Konica Minolta).

[0128] (Evaluation method) Using a spectrophotometer (CM3500d: manufactured by Konica Minolta), * Thermal test by value The coloring of the formulation after the accelerated test was evaluated. * value, and 4°C b of the reference sample corresponding to each embodiment stored in a thermostatic chamber for one week * Measure the value and In the examples, the difference between the samples after the accelerated test and the corresponding reference samples is * The difference in values ​​(Δb * Value = b of sample after accelerated test * Value - b of the reference sample * The value was calculated and evaluated. b * The value is used as an index of transparency. * The higher the value, the more likely the formulation is to be used. This indicates that the coloring suppression effect of * value and Δb * The results of the values ​​are shown in Tables 1 to 3. is also shown.

[0129] (Color difference judgment criteria) ◎ Δb * Less than 0.4 ○ Δb * 0.4 or more and less than 0.5 × Δb * 0.5 or higher

[0130] [Table 1]

[0131] [Table 2]

[0132] [Table 3]

[0133] As shown in Table 1, coloring did not occur simply by adding component (B) (Comparative Example 1). Component (A) 3% by mass or more of nicotinamide, component (B) hyaluronic acid and its salts, and When two or more of these derivatives are mixed together, coloring may occur. On the other hand, as shown in Tables 2 and 3, in each Example, In the case where the composition further contains an amphiphilic compound (C), coloring over time is suppressed. It was recognized that.

[0134] [Test Example 2 Thermal Stability Test] Various components were mixed in the compositions shown in Tables 4 to 6 below by a conventional method to prepare samples, and then The sample was placed in a 20 mL glass vial and incubated in a thermostatic chamber set at 60°C for one week. After one week, the changes in color (changes in appearance and color difference) were evaluated visually and with a spectrophotometer. The evaluation method was the same as in Test Example 1.

[0135] [Coloring suppression degree] In addition to the evaluation method of Test Example 1, Δb * Based on the value, Δb due to addition of component C * The effect on the value was evaluated by calculating the degree of color inhibition using the following formula. did. Coloring suppression degree = (Δb of the comparative example where the problem occurred * Value - Δb of each example * Value) / each example Δb * Value x 100 In Examples 2-1 to 2-10, the coloring inhibition degree was calculated based on the results of Comparative Example 2-1. Δb * values ​​were used.

[0136] (Coloring suppression degree judgment criteria) ◎ Coloring suppression degree 30% or more ○ Color suppression rate: 10% to less than 30% △ Color suppression rate: 4% or more and less than 10%

[0137] [Table 4]

[0138] [Table 5]

[0139] [Table 6]

[0140] As shown in Table 4, coloring did not occur by simply adding component (B) (Comparative Example 1). Component (A) 5% by mass or more of nicotinamide; Component (B) hyaluronic acid or a derivative thereof; And when two or more of these salts are mixed together, coloring occurs. However, a new problem was found (Comparative Example 2-1). On the other hand, as shown in Tables 5 and 6, each Example In the above, when an amphiphilic compound (C) is further contained, coloring over time is suppressed. In addition, when nicotinic acid amide (A) is blended at 5% by mass or more, Even if the coexisting ingredient (B) is only acetylated sodium hyaluronate, A new problem different from the above was found, that is, the following occurs (Comparative Example 2-4). (A) Regarding the problem of blending 5% by mass or more of nicotinic acid amide, examples are given below. When the amphiphilic compound (C) used in Examples 2-1 to 2-10 was included, It was found that the coloring was suppressed.

[0141] [Test Example 3: Thermal Stability Test] Various components were mixed in the compositions shown in Tables 7 and 8 below in a conventional manner to prepare samples, and then The sample was placed in a 20 mL glass vial and incubated in a thermostatic chamber set at 60°C for one week. After one week, the changes in color (changes in appearance and color difference) were evaluated visually and with a spectrophotometer. The evaluation method was the same as in Test Example 2. As a standard for calculating the degree of color suppression, Δb * values ​​were used.

[0142] [Table 7]

[0143] [Table 8]

[0144] As shown in Table 7, coloring did not occur by simply adding component (B) (Comparative Example 3-1 ), component (A) 5% by mass or more of nicotinamide, and component (B) hyaluronic acid and its derivatives When two or more kinds selected from the group consisting of the body and its salt are mixed together, coloring may occur. On the other hand, as shown in Table 8, in each Example, In addition, when the amphiphilic compound (C) is further contained, coloring over time is suppressed. It was acknowledged that:

[0145] [Test Example 4 Thermal Stability Test] After preparing samples by mixing various components according to the compositions shown in Tables 9 and 10 below in a conventional manner, The sample was placed in a 20 mL glass vial and incubated in a thermostatic chamber set at 60°C for one week. After one week, the changes in color (changes in appearance and color difference) were evaluated visually and using a spectrophotometer. The evaluation method was the same as in Test Example 2. In Examples 4-1 to 4-3, As a criterion for calculating the degree of coloring inhibition, Δb * values ​​were used.

[0146] [Table 9]

[0147] [Table 10]

[0148] As shown in Table 9, coloring did not occur by simply adding component (B) (Comparative Example 4-1 ), component (A) 5% by mass or more of nicotinamide, and component (B) hyaluronic acid and its derivatives When two or more kinds selected from the group consisting of the body and its salt are mixed together, coloring may occur. On the other hand, as shown in Table 10, in each Example, In the case where the composition further contains an amphiphilic compound (C), coloring over time is suppressed. It was recognized that.

[0149] [Test Example 5 Thermal Stability Test] Samples were prepared by mixing various components according to the compositions shown in Tables 11 to 13 below in a conventional manner. After that, the sample was placed in a 20 mL glass vial and placed in a thermostatic chamber set at 60°C for one week. After one week, the color change (change in appearance and color difference) was observed visually and with a spectrophotometer. The evaluation method was the same as in Test Example 2. is the standard for calculating the degree of color inhibition, Δb * values ​​were used.

[0150] [Table 11]

[0151] [Table 12]

[0152] [Table 13]

[0153] As shown in Table 11, coloring did not occur by simply adding component (B) (Comparative Example 5- 1) Component (A) nicotinamide (3% by mass or more) and component (B) hyaluronic acid and its derivatives and two or more selected from the group consisting of conductors, salts thereof, and heparinoids. A new problem was found that when the cellulose acetate solution was mixed with the cellulose acetate solution, coloring occurred (Comparative Example 5-2). On the other hand, as shown in Tables 12 and 13, in each Example, (C) an amphiphilic compound It was found that when the composition was added, coloring over time was suppressed.

[0154] [Formulation example] Based on the formulations shown in Tables 14 to 39 below, the skin topical compositions of the present invention (Formulation Examples 1 to 2) were 6) was prepared.

[0155]

Table 14

[0156]

Table 15

[0157]

Table 16

[0158]

Table 17

[0159]

Table 18

[0160]

Table 19

[0161]

Table 20

[0162]

Table 21

[0163]

Table 22

[0164]

Table 23

[0165]

Table 24

[0166]

Table 25

[0167]

Table 26

[0168]

Table 27

[0169]

Table 28

[0170]

Table 29

[0171]

Table 30

[0172]

Table 31

[0173]

Table 32

[0174]

Table 33

[0175]

Table 34

[0176] [Table 35]

[0177] [Table 36]

[0178] [Table 37]

[0179] [Table 38]

[0180] [Table 39]

[0181] In all of the formulation examples, a composition for external use on the skin in which coloring was suppressed was obtained. It was a good composition for external application to the skin that also had an excellent feel.

Claims

[Claim 1] (A) nicotinic acid amide 3% by mass or more; (B) two or more selected from the group consisting of hyaluronic acid, its derivatives, salts thereof, and heparinoids; and (C) Amphiphilic Compound A composition for external use on the skin comprising:

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