Bathing method for preparing for sleep

Abstract

To provide a bathing method for preparing for sleep that can help falling asleep more easily and improve the quality of sleep.SOLUTION: Provided is a bathing method for preparing for sleep, in which bathing is performed in hot water with dissolved bath additives, the bath additives containing a bicarbonate salt consisting of sodium bicarbonate or potassium bicarbonate and an organic acid as a composition, the mixing ratio of the composition being set so that the hot water with dissolved bath additives becomes approximately neutral, and bathing is performed under bathing conditions that make the bather's deep body temperature approximately 0.2°C or more higher than when bathing in normal hot water, and the bathing is completed approximately 60 to 120 minutes before the intended time of falling asleep.SELECTED DRAWING: Figure 8

Description

[Technical field]

[0001] The present invention relates to a bathing method for preparing for sleep, and more particularly to a bathing method for preparing for sleep by bathing in hot water having dissolved bicarbonate ions. [Background technology]

[0002] In today's stressful society, sleep is important for maintaining a healthy mind and body, and it is necessary to fall asleep easily in order to get good quality sleep. A person's deep body temperature is high when awake and low when asleep, and as falling asleep is related to deep body temperature, changing deep body temperature by bathing can promote smooth sleep.

[0003] As an example of technology that focuses on the relationship between bathing, body temperature, and sleep, the following Patent Document 1 discloses a bath system that includes a water temperature detection means for detecting the temperature of the water stored in a bathtub in which a bather bathes, a determination means for determining the time when the bather will leave the stored water and the time when the bather will begin to sleep based on the water temperature, and a notification means for notifying the bather of the time when the bather will leave the bath and the time when the bather will begin to sleep. The determination means determines the depth of the bather's sleep based on the physical condition information. It is disclosed that the method comprises the steps of: a first step of estimating the bather's core body temperature; a second step of estimating the amount of rise in core body temperature while the bather is bathing in the stored water based on the water temperature and the core body temperature; a third step of determining the recommended bathing time, which is the time required to raise the bather's core body temperature by a predetermined target amount based on the estimated amount of rise, and setting the recommended bathing time as the timing to leave the bath; and a fourth step of determining the time to fall asleep based on the water temperature and the recommended bathing time. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2021-120604 A [Patent Document 2] Patent No. 5588490 [Patent Document 3] Patent No. 5877778 [Patent Document 4] Patent No. 6525945 [Non-patent literature]

[0005] [Non-Patent Document 1] Nobuhiro Maruyama and Shigeji Koboshi, "No. 29 Development of bicarbonate ion-citric acid bath additives and measures to prevent illness", Journal of the Japanese Society of Balneology, Climatology, and Physical Medicine, Vol. 78, No. 1 Summary of the Invention [Problem to be solved by the invention]

[0006] During sleep, the core body temperature drops to allow the organs, muscles, and brain to rest. This core body temperature is regulated by heat production by the muscles and internal organs and heat dissipation from the hands and feet. Before falling asleep, the hands and feet become warm and dissipate more heat from the hands and feet, causing the core body temperature to drop. However, because the core body temperature is under the influence of homeostasis, it does not drop easily.

[0007] Since deep body temperature has the tendency to drop sharply when it temporarily rises, if you can raise your deep body temperature by taking a bath, your deep body temperature will drop sharply a while after you have finished bathing. As a result, your deep body temperature will drop sharply, and the switch for falling asleep (called the body temperature switch) will turn on, allowing you to fall asleep smoothly.

[0008] However, simply taking a bath in normal hot water may raise the skin temperature, but it does not raise the core body temperature efficiently. To solve this problem, the use of bath additives is considered, but the commonly used bath additives generate carbon dioxide gas through a neutralization reaction, and the carbon dioxide gas bubbles merge and grow in the water, and the buoyancy of the bubbles causes the carbon dioxide gas to rise quickly and be released into the air, so the bathing effect of carbon dioxide gas is not very good and the core body temperature cannot be raised efficiently.

[0009] Therefore, the inventors of the present application have proposed a tablet manufacturing method and tablet production method in which an organic acid is used as a compound that neutralizes the bicarbonate (sodium bicarbonate, potassium bicarbonate) as a carbon dioxide gas generating source, and the tablet is compressed in the presence of polyethylene glycol to produce tablets of a certain hardness and a certain size (Patent Documents 2-4).

[0010] Inside the tablets produced by the methods of Patent Documents 2-4, a vigorous and efficient neutralization reaction occurs, and by continuously releasing the smallest possible carbon dioxide bubbles for a certain period of time, most of the generated carbon dioxide can be dissolved in water without escaping into the air. In addition, by designing the pH to be neutral immediately after dissolution, the bicarbonate ions in the water are highly concentrated, and due to the pH of the aqueous solution, carbon dioxide that comes into contact with the skin easily becomes bicarbonate ions, and becomes highly concentrated when combined with the naturally existing bicarbonate ions, allowing the absorption of bicarbonate ions into the blood vessels from the skin to be maximized, and the blood flow is increased by the transdermal absorption of bicarbonate ions, allowing the core body temperature to be efficiently raised.

[0011] However, even if bath additives such as those in Patent Documents 2-4 (called neutral bicarbonate bath additives) are used, unless the bathing conditions are appropriate, the promotion of blood flow will not be sufficient to properly raise core body temperature. Furthermore, unless the timing of bathing and falling asleep is appropriately set, the reduction in core body temperature will not be sufficient, and smooth onset of sleep will not be promoted.

[0012] The present invention has been made in consideration of the above-mentioned problems, and its main objective is to provide a bathing method for preparing for sleep which sets bathing conditions in which bathing is done in water containing dissolved bicarbonate ions so that the deep body temperature rises appropriately, and sets the timing of bathing and falling asleep so as to ensure a large reduction in deep body temperature, thereby promoting smooth onset of sleep and improving the quality of sleep. [Means for solving the problem]

[0013] One aspect of the present invention is a bathing method for preparing for sleep, in which the bather takes a bath in water with dissolved bath additives, the bath additives comprising a bicarbonate salt consisting of sodium bicarbonate or potassium bicarbonate and an organic acid as a composition, the mixing ratio of the composition being set so that the water with the dissolved bath additives is approximately neutral, the bathing is performed under bathing conditions such that the bather's deep body temperature is approximately 0.2°C or more higher than when bathing in normal water, and the bathing is completed approximately 60 to 120 minutes before the intended time of falling asleep. Effect of the Invention

[0014] The bathing method for preparing for sleep of the present invention can promote smooth onset of sleep and improve the quality of sleep.

[0015] The reason for this is that when taking a bath in hot water with dissolved bath additives in preparation for sleep, the bath additives used contain a bicarbonate salt consisting of sodium bicarbonate or potassium bicarbonate and an organic acid, with the mixing ratio of the composition set so that the dissolved aqueous solution is approximately neutral, the bath is taken under bathing conditions that make the bather's deep body temperature approximately 0.2°C or more higher than when bathing in normal hot water, and the bath is finished approximately 60 to 120 minutes before the intended time of falling asleep. [Brief description of the drawings]

[0016] [Figure 1] FIG. 1 is a schematic diagram illustrating changes in deep body temperature. [Diagram 2] FIG. 1 is a schematic diagram illustrating the mechanism by which blood flow increases due to transdermal absorption of bicarbonate ions. [Diagram 3]FIG. 13 is a diagram showing the correlation between bathing time and blood flow rate in one embodiment of the present invention. [Figure 4] FIG. 13 is a diagram showing the correlation between bathing temperature and blood flow rate in one embodiment of the present invention. [Diagram 5] FIG. 1 is a graph showing the correlation between bicarbonate ion concentration and blood flow rate according to one embodiment of the present invention. [Figure 6] FIG. 13 is a graph showing the effect of increasing core body temperature by bicarbonate bathing in one embodiment of the present invention. [Figure 7] FIG. 13 is a graph showing the effect of increasing core body temperature by continuously taking a bicarbonate bath in accordance with one embodiment of the present invention. [Figure 8] FIG. 13 is a diagram showing changes in deep body temperature after bathing in one embodiment of the present invention. [Figure 9] Items and assessment criteria of the Pittsburgh Sleep Quality Index. [Figure 10] FIG. 13 is a graph showing the effect of continued bicarbonate bathing on improving sleep quality as measured by the Pittsburgh Sleep Quality Index. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] As explained in the background art, a person's core body temperature changes so that it is high when awake and low when asleep. In addition, when the core body temperature rises temporarily, it has the tendency to drop significantly by the same amount. For these reasons, if the core body temperature can be raised by taking a bath, the core body temperature will drop significantly a while after the bath, and the extent of the drop in core body temperature can be increased, turning on the body temperature switch and allowing you to fall asleep smoothly.

[0018] For example, if one does not take a bath, then the core body temperature will drop gradually from dusk to dawn, but if one takes a bath (hatched area), then the core body temperature will rise once and then drop significantly, as shown in Figure 1. Also, a person with a high body temperature (solid line) will experience a greater drop in core body temperature after bathing (about 90 minutes later in this case) than a person with a low body temperature (dashed line), which will result in them being able to fall asleep more smoothly and improving the quality of their sleep.

[0019] Therefore, in order to improve the quality of sleep, it is important to take a bath that can raise the core body temperature more significantly. As a bath additive to be used for this purpose, the inventors of the present application have proposed a tablet that can increase the concentration of bicarbonate ions in the water and raise the core body temperature by promoting blood flow (Patent Documents 2-4).

[0020] The effect of bicarbonate ions will now be explained. Generally, carbon dioxide dissolved in water exists as dissolved inorganic carbon, but this dissolved inorganic carbon exists in three forms due to bicarbonate equilibrium, and it is said that the form changes depending on the pH of the solution. It is known that the abundance ratio of the three types of dissolved inorganic carbon depending on the pH is such that in the region where the pH of the solution is weakly acidic or lower, the proportion of bicarbonate ions is low and the proportion of carbonic acid is high, in the neutral to weakly alkaline region, the proportion of bicarbonate ions is highest, and in the alkaline region, the bicarbonate ions are low and the carbonate ions are high, symmetrically.

[0021] In addition, carbon dioxide is said to migrate from the skin surface to the capillaries via an accessory organ pathway that passes through the pores and sweat glands of the skin. Since the pH range of blood coincides with the pH range in which bicarbonate ions are present at their highest concentration, the inventors of the present application focused on the possibility that much of the carbon dioxide that migrates from the skin into the blood may exert physiological activity as bicarbonate ions and have beneficial effects on the living body, and investigated the effects of bicarbonate ions on the living body (see non-patent document 1).

[0022] As a result, in an in vivo test, blood flow in mice was significantly increased compared to the control group, and there was a tendency for an increase in the amount of bicarbonate ions in the blood and in NO production via phosphorylation of endothelial nitric oxide synthase in peripheral blood. Furthermore, in an in vitro test using human umbilical artery endothelial cells, promotion of phosphorylation of endothelial nitric oxide synthase and an increase in NO production were detected in the presence of neutral bicarbonate ion water, and the reactive oxygen species scavenging activity of neutral bicarbonate ion water was significantly higher than that of the control group.

[0023] From these findings, it was revealed that bicarbonate ions are absorbed percutaneously and act directly on the vascular endothelium to phosphorylate endothelial nitric oxide synthase, thereby promoting blood flow by increasing NO production, and it was confirmed that the use of the tablets in Patent Documents 2-4 as bath additives is effective.

[0024] However, even if a neutral bicarbonate bath additive such as those described in Patent Documents 2-4 is used, unless the bathing conditions are appropriate, the promotion of blood flow will not adequately raise the core body temperature, and unless the timing of bathing and falling asleep is appropriately set, the drop in core body temperature will be too great and it will not be possible to fall asleep smoothly.

[0025] Therefore, the inventors of the present application investigated the correlation between the time spent bathing in water containing dissolved neutral bicarbonate bath additives and blood flow, the correlation between the temperature of the water in which the neutral bicarbonate bath additives are dissolved and blood flow, the correlation between the bicarbonate ion concentration in the water and blood flow, the correlation between the time spent bathing in water containing dissolved neutral bicarbonate bath additives and deep body temperature, and the correlation between the time after bathing and deep body temperature, and investigated the appropriate bathing conditions for preparing for sleep and the timing of bathing and falling asleep.

[0026] As a result, when bathing in water with dissolved bicarbonate ions, deep body temperature rose significantly with increasing bathing time compared to bathing in regular water, and the difference in deep body temperature compared to bathing in regular water was approximately 0.2°C or more. This shows that bathing in water with dissolved bicarbonate ions can raise deep body temperature by approximately 0.2°C or more compared to bathing in regular water, and as a result, it can increase the degree of decrease in deep body temperature, promote smoother onset of sleep, and improve sleep quality.

[0027] In addition, when bathing in water with dissolved bicarbonate ions, the deep body temperature rises due to the promotion of blood flow, so the drop in deep body temperature is slower than when bathing in normal water. Therefore, it is necessary to extend the time between bathing and falling asleep, and it was found that 60 to 120 minutes is an appropriate time. From this, it was found that if bathing is completed about 60 to 120 minutes before the intended time of falling asleep, the extent of the drop in deep body temperature can be ensured, which promotes smooth falling asleep and improves the quality of sleep. EXAMPLES

[0028] In order to explain the above-mentioned embodiment of the present invention in more detail, a bathing method for preparing for sleep according to an embodiment of the present invention will be described with reference to Figs. 2 to 10. Fig. 2 is a schematic diagram for explaining the mechanism of an increase in blood flow rate due to transdermal absorption of bicarbonate ions, Fig. 3 is a diagram showing the correlation between bathing time and blood flow rate in this embodiment, Fig. 4 is a diagram showing the correlation between bathing temperature and blood flow rate in this embodiment, and Fig. 5 is a diagram showing the correlation between bicarbonate ion concentration and blood flow rate in this embodiment. Fig. 6 is a diagram showing the correlation between bathing time and deep body temperature in this embodiment, Fig. 7 is a diagram showing the effect of increasing deep body temperature by continuing bicarbonate bathing in this embodiment, and Fig. 8 is a diagram showing the correlation between the elapsed time after bathing and deep body temperature in this embodiment. Fig. 9 is a diagram showing the items and evaluation criteria of the Pittsburgh Sleep Quality Index, and Fig. 10 is a diagram showing the effect of improving sleep quality by continuing bicarbonate bathing according to the Pittsburgh Sleep Quality Index.

[0029] First, the mechanism by which blood flow increases due to the effect of bicarbonate ion concentration will be explained. Figure 2 shows a schematic diagram of the structure of a human blood vessel, with the dermis / subcutaneous adipose tissue 2 inside the epidermis 1, and blood vessels 5 inside the dermis / subcutaneous adipose tissue 2. The blood vessels 5 are composed of a vascular wall 6 having smooth muscle 7 and vascular endothelial cells 8 inside the vascular wall 6, and the inside of the vascular endothelial cells 8 is the inside of the blood vessel 9. When a person bathes in hot water in which bicarbonate ions are dissolved, as shown in Figure 2, the bicarbonate ions penetrate into the blood vessels 9 through sweat pores 4, etc., and phosphorylate the endothelial nitric oxide synthase (eNOS) present in the vascular endothelial cells 8 (P-eNOS), which acts on L-arginine (L-Al) to generate nitric oxide (NO). The generated NO generates cyclic guainosine monophosphate (cGMP) via guanosine triphosphate (GTP) by guanylate cyclase enzyme (sGC). The cGMP then relaxes the smooth muscle 7 in the vascular wall 6, resulting in dilation of the blood vessels 5 and increased blood flow.

[0030] Therefore, by increasing the concentration of bicarbonate ions in the water, the effects of bathing can be enhanced, such as promoting blood flow through transdermal absorption of bicarbonate ions and raising core body temperature. However, in order to maximize this effect, it is necessary to optimize the bathing conditions related to the transdermal absorption of bicarbonate ions (the time spent bathing in water with dissolved bath additives, the temperature of the water in which the bath additives are dissolved, the concentration of bicarbonate ions in the water, etc.).

[0031] Therefore, we investigated bathing conditions to maximize the bathing effect. As mentioned above, when bicarbonate ions are absorbed through the skin, nitric oxide (NO) is generated in blood vessels, which expand the blood vessels and accelerate the blood flow. Therefore, we investigated the optimal bathing time, bathing temperature, and bicarbonate ion concentration by measuring the blood flow rate of the subjects while bathing. This blood flow rate was measured using a non-contact laser Doppler blood flow meter (ALF21N manufactured by Advance Co., Ltd.) by converting the reflected light from the tissue when a laser beam was irradiated onto the biological tissue into an electrical signal and processing it. The measurement was performed at the dorsal side of the hand, which corresponds to the so-called "Hegu" point, and the measurement was performed by attaching a measurement glove to the skin. The unit of blood flow is mL / min / 100g-tissue, but here it is expressed as a multiple of the value before bathing, and the average value of the data obtained by the subjects for 5 days was used.

[0032] First, 210 L of hot water was poured into the bathtub and the bathing temperature was adjusted to 39°C, and neutral bicarbonate bath additives, such as those shown in Patent Documents 2-4, which dissolve the bath additive in water to make it approximately neutral, were added to adjust the bicarbonate ion concentration to 2 mmol / L, and the change in blood flow over time was measured when 10 subjects (healthy women aged 20 to 60 years) bathed in the bathtub. For comparison, the change in blood flow over time was also measured when 10 subjects bathed in normal water at 39°C. The results are shown in Table 1 and Figure 3.

[0033] [Table 1]

[0034] Fig. 3 shows the correlation between bathing time and blood flow. As shown by the dashed line in Fig. 3, when bathing in normal hot water, body temperature rises and blood flow temporarily increases by about two times due to the action of the autonomic nerves, but the increase in blood flow stops after about 10 minutes, and thereafter, even if the bathing time is extended, blood flow hardly changes. On the other hand, as shown by the solid line in Fig. 3, when bathing in hot water in which the neutral bicarbonate bath agent of this embodiment is added and the bicarbonate ion concentration is adjusted to 2 mmol / L, bicarbonate ions are absorbed transdermally over time, generating nitric oxide in the blood vessels, and cyclic guainosine phosphate generated from nitric oxide relaxes the smooth muscles and expands the blood vessels. As a result, after 10 minutes, the blood flow rate increased to about 5 times that before bathing (considering that the blood flow rate increases about twice when bathing in normal hot water, the increase in blood flow rate due to the transdermal absorption of bicarbonate ions is essentially about 4 times), and after 20 minutes, the blood flow rate increased to about 6 times that before bathing (similarly, considering that the blood flow rate increases about twice when bathing in normal hot water, the increase in blood flow rate due to the transdermal absorption of bicarbonate ions is essentially about 5 times), and the blood flow rate gradually increased as the bathing time increased thereafter. From the results in Figure 3, the blood flow rate was clearly increased when bathing in hot water with dissolved bicarbonate ions compared to when bathing in normal hot water, and considering the significant difference in blood flow rate compared to when bathing in normal hot water, it can be said that the optimal bathing condition is a bathing time of 10 minutes or more, preferably 20 minutes or more, and it was found that when bathing for 10 minutes or more, the blood flow rate was about 4 times or more than before bathing, and when bathing for 20 minutes or more, the blood flow rate was about 5 times or more than before bathing.

[0035] Next, 210 L of hot water was poured into the bathtub to change the bathing temperature, and the neutral bicarbonate bath additive of this example was added to adjust the bicarbonate ion concentration to 2 mmol / L. The blood flow rate was measured when 10 subjects (healthy women aged 20 to 60 years) bathed for 20 minutes. For comparison, the blood flow rate was measured when 10 subjects bathed for 20 minutes in normal hot water with the temperature changed. The results are shown in Table 2 and Figure 4.

[0036] [Table 2]

[0037] FIG. 4 is a diagram showing the correlation between bathing temperature and blood flow rate. As shown by the dashed line in FIG. 4, when bathing in normal hot water, body temperature rises with an increase in bathing temperature, and blood flow rate gradually increases due to the action of the autonomic nerves, but the increase in blood flow rate was about 2.4 times or less. On the other hand, as shown by the solid line in FIG. 4, when bathing in hot water in which the neutral bicarbonate bath agent of this embodiment is added and the bicarbonate ion concentration is adjusted to 2 mmol / L, the activity of enzymes (endothelial nitric oxide synthase, guanylate cyclase enzyme, etc.) increases with an increase in bathing temperature, the production of nitric oxide and cyclic guainosine phosphate increases, the relaxation effect of smooth muscles is strengthened, and blood vessels greatly expand. As a result, at 29°C, the blood flow rate is about 3.1 times that before bathing, at 32°C, the blood flow rate is about 5 times that before bathing, and at 40°C, the blood flow rate is about 6.1 times that before bathing, and thereafter, although the change in blood flow rate becomes more gradual, at 43°C, the blood flow rate is about 6.2 times that before bathing. The results in Figure 4 show that when bathing in water with dissolved bicarbonate ions, blood flow is clearly increased compared to bathing in regular water. Considering the significant difference in blood flow compared to bathing in regular water, it can be said that the optimal bathing conditions are a bathing temperature of 29°C to 43°C, preferably 32°C to 40°C.

[0038] Next, 210 L of hot water was poured into the bathtub to adjust the bathing temperature to 39°C, and the neutral bicarbonate bath additive of this example was poured into the bath to change the bicarbonate ion concentration. The blood flow rate was measured when 10 subjects (healthy women aged 20 to 60 years) bathed for 20 minutes. The results are shown in Table 3 and Figure 5. The reason why the blood flow rate at a bicarbonate ion concentration of 0 mmol / L is twice that before bathing is that, as shown in Table 1, the increase in blood flow rate when bathing for 20 minutes in normal hot water at 39°C is twice that before bathing. In addition, in Figure 5, the bicarbonate ion concentration range is changed on the left and right sides of the graph to make it easier to understand the change in blood flow rate under conditions of low bicarbonate ion concentration (1 mmol / L or less).

[0039] [Table 3]

[0040] FIG. 5 is a diagram showing the correlation between bicarbonate ion concentration and blood flow rate. As shown by the solid line in FIG. 5, when taking a bath in hot water in which the neutral bicarbonate bath agent of this embodiment is added and the bicarbonate ion concentration is changed, sufficient nitric oxide is generated even with a small amount of bicarbonate ion absorbed percutaneously, and cyclic guainosine phosphate generated from nitric oxide relaxes smooth muscles and expands blood vessels. As a result, the blood flow rate increases rapidly to about 4.8 times before bathing at 0.1 mmol / L and about 5.3 times before bathing at 0.2 mmol / L, and then increases gradually to about 6.2 times before bathing at 5 mmol / L and about 6.4 times before bathing at 10 mmol / L. From the results in FIG. 5, it can be said that the optimal bathing conditions for bicarbonate ion concentration are 0.1 mmol / L to 10 mmol / L, where blood flow rate increases significantly, and preferably 0.2 mmol / L to 5 mmol / L.

[0041] Since it is believed that the increase in blood flow due to the transdermal absorption of bicarbonate ions will raise the core body temperature, the correlation between bathing time and core body temperature was investigated. To measure the core body temperature, a core thermometer (CORE manufactured by GreenTEG) was used, and the heat flux (amount of heat energy flowing through a unit area per unit time) was measured with a highly sensitive sensor, and the internal body temperature (core body temperature) was calculated from the temperature on the skin surface by processing it with an algorithm. The measurement was performed on the wrist, using a 3cm x 3cm patch-type sensor fixed to the wrist with a band. Note that the change from the value before bathing was expressed here, and the average value of the data obtained by the subject for 5 days was used.

[0042] As in the case of investigating the correlation between bathing time and blood flow, 210 L of hot water was poured into the bathtub and the bathing temperature was adjusted to 39°C, and the neutral bicarbonate bath additive of this example was added to adjust the bicarbonate ion concentration to 2 mmol / L, and the time change in deep body temperature was measured when 10 subjects (healthy women aged 20 to 60 years) bathed in the bath. For comparison, the time change in body temperature was also measured when 10 subjects bathed in normal hot water at 39°C. The results are shown in Table 4 and Figure 6.

[0043] [Table 4]

[0044] FIG. 6 is a diagram showing the correlation between bathing time and deep body temperature. As shown by the dashed line in FIG. 6, when bathing in normal hot water, the blood flow rate increases due to the action of the autonomic nerves, but the deep body temperature does not rise so much. On the other hand, as shown by the solid line in FIG. 6, when bathing in hot water in which the neutral bicarbonate bath agent of this embodiment is added and the bicarbonate ion concentration is adjusted to 2 mmol / L, the bicarbonate ions are absorbed transdermally and nitric oxide is generated in the blood vessels, and the cyclic guainosine phosphate generated from the nitric oxide relaxes the smooth muscles, expanding the blood vessels and increasing the blood flow rate. As a result, after 10 minutes, the deep body temperature rose by about 0.7°C (about 0.5°C in the case of normal hot water) from the value before bathing, and after 20 minutes, the body temperature rose by about 1.5°C (about 1.1°C in the case of normal hot water) from the value before bathing, and the deep body temperature continued to rise gradually as the bathing time increased. From the results in Figure 6, when bathing in water with dissolved bicarbonate ions, the deep body temperature is clearly higher than when bathing in normal water, and it is clear that bathing in water with dissolved bicarbonate ions warms the body from the core. From the results in Figure 6, considering the significant difference in body temperature compared to when bathing in normal water, it can be said that the optimal bathing conditions are a bathing time of 10 minutes or more, preferably 20 minutes or more, and it was found that when bathing under these bathing conditions, the deep body temperature is about 0.2°C higher than when bathing in normal water.

[0045] Next, we investigated how the deep body temperature before sleep changes when bathing under the above bathing conditions is performed every day. The bath temperature was adjusted to 38°C, the neutral bicarbonate bath agent of this embodiment was added, and 50 subjects (men and women with an average age of 46.8 years) were made to bathe for 30 minutes every day for 4 weeks. The deep body temperature before sleep was measured. For comparison, 50 subjects were made to bathe for 30 minutes in normal hot water at 38°C every day for 4 weeks. The results are shown in Table 5 and Figure 7.

[0046] [Table 5]

[0047] FIG. 7 is a diagram showing the correlation between the duration of bathing and the deep body temperature before sleep. As shown by the dashed line in FIG. 7, when bathing in normal hot water, even if bathing is performed every day for four weeks, the deep body temperature before sleep only rises by about 0.1°C. On the other hand, as shown by the solid line in FIG. 7, when bathing in hot water containing the neutral bicarbonate bath agent of this embodiment, the deep body temperature before sleep rises by about 0.2°C after one week, and the deep body temperature remains high thereafter. From the results in FIG. 7, it was found that when bathing in hot water containing dissolved bicarbonate ions, the deep body temperature before sleep can be maintained at a higher level than when bathing in normal hot water, and that by bathing every day for more than one week, the deep body temperature before sleep can be raised by about 0.2°C.

[0048] Next, we investigated how the deep body temperature changed after bathing. For 50 subjects (male and female, average age 46.8 years), the bath temperature was adjusted to 38°C, and the neutral bicarbonate bath agent of this example was added to the bath for 30 minutes, after which the deep body temperature was measured for 120 minutes. For comparison, for 50 subjects, the deep body temperature was measured for 120 minutes after 30 minutes of bathing in normal water at 38°C. The results are shown in Table 6 and Figure 8.

[0049] [Table 6]

[0050] FIG. 8 is a diagram showing the correlation between the duration of bathing and the deep body temperature. As shown by the dashed line in FIG. 8, when bathing in normal hot water, the deep body temperature returns to normal 30 minutes after bathing. On the other hand, as shown by the solid line in FIG. 8, when bathing in hot water containing the neutral bicarbonate bath agent of this embodiment, the deep body temperature rises due to the expansion of blood vessels and the increase in blood flow, so the time until the deep body temperature returns to normal is longer, and the deep body temperature becomes almost constant about 60 to 120 minutes after bathing. From the results in FIG. 8, it was found that when bathing in hot water containing dissolved bicarbonate ions, in order to ensure a reduction in the deep body temperature, it is important to end the bath at least about 60 minutes before the planned time to fall asleep, preferably about 60 to 120 minutes before the planned time to fall asleep.

[0051] Next, the sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) when the bathing method of the present invention was performed. The Pittsburgh Sleep Quality Index (PSQI) evaluates sleep over the past month based on the following items: sleep quality, time to fall asleep, sleep duration, sleep efficiency, difficulty in sleeping, use of sleeping pills, and difficulty in waking during the day. The lower the score, the higher the quality of sleep. Figure 9 shows the items asked in the Pittsburgh Sleep Quality Index and the criteria for answering the questions.

[0052] The subjects who had taken baths in hot water with dissolved bicarbonate ions for four consecutive weeks and those who had taken baths in normal water for four consecutive weeks were asked questions shown in Fig. 9 before and after the start of bathing. Scores were calculated for the answers based on the criteria shown in Fig. 9, and the rate of change in the scores was examined. As a result, as shown in Fig. 10, the rate of change in sleep score for the subjects who had taken baths in normal water was -23.5%, while the rate of change in sleep score for the subjects who had taken baths in hot water with dissolved bicarbonate ions was -37.5%. It was confirmed that the rate of change in sleep score was significantly reduced (great improvement) by continuously taking baths in hot water with dissolved bicarbonate ions, and that the bathing method of the present invention is effective in improving the quality of sleep.

[0053] As explained above, bathing for 10 minutes or more with a water temperature of 29-43°C and a bicarbonate ion concentration of 0.1-10 mmol / L (preferably bathing for 20 minutes or more with a water temperature of 32-40°C and a bicarbonate ion concentration of 0.2-5 mmol / L), preferably by continuing this bathing for one week or more, can increase deep body temperature by about 0.2°C due to the promotion of blood flow through transdermal absorption of bicarbonate ions. It has been found that if bathing under these bathing conditions is ended at least about 60 minutes, preferably about 60-120 minutes, before the intended time of falling asleep, a large reduction in deep body temperature can be ensured, which can promote smooth falling asleep and improve the quality of sleep.

[0054] Next, typical neutral bicarbonate bath additives (first neutral bicarbonate bath additive and second neutral bicarbonate bath additive) that can be used in the above-mentioned bicarbonate bath will be described.

[0055] [The No. 1 neutral bicarbonate bath additive] The first neutral bicarbonate bath agent used in the bicarbonate bath of this embodiment is a compressed tablet containing a bicarbonate (sodium bicarbonate or potassium bicarbonate) in a predetermined ratio of organic acid, a predetermined ratio of polyethylene glycol, and, if necessary, a predetermined ratio of anhydride (anhydrous sodium carbonate or anhydrous potassium carbonate). For example, it is a compressed tablet containing 1 / 10 to 1 / 3 organic acid, 1 / 100 to 1 / 5 polyethylene glycol, and 1 / 100 to 1 / 10 anhydride (anhydrous sodium carbonate or anhydrous potassium carbonate) in a predetermined ratio of bicarbonate (sodium bicarbonate or potassium bicarbonate), and the pH of the aqueous solution immediately after dissolving the tablet is 5.5 to 8.5.

[0056] Examples of organic acids that can be used include citric acid, succinic acid, and malic acid. By using an organic acid that contains at least citric acid, the neutralization reaction in the tablet can be sustained more effectively and fine bubbles can be generated.

[0057] In addition, when bicarbonate is granulated in a fluidized bed to obtain a granulated product, the reaction in the tablet can be efficiently enhanced by using a mechanical fluidized bed granulator that does not substantially use air for stirring. In a fluidized bed with a mechanical stirring method, air is not used for stirring, and the powder is fluidized using mechanical blades such as a propeller, so there is no absorption of moisture brought in from humid air during granulation.

[0058] Mechanical fluidized bed granulators that do not essentially use air for agitation are mixers that have a plough-like shovel inside a horizontal drum to create centrifugal diffusion and vortex flow effects, resulting in three-dimensional fluidization. For example, they are sold on the market by Deutsche Loedige AG or Matsuzaka Giken Co., Ltd.

[0059] It is more preferable that the granulator is equipped with a vacuum pump for reducing the pressure. By applying a vacuum with a vacuum pump during granulation, the amount of polyethylene glycol can be reduced and granulation can be performed, so that the diameter of the foamed bubbles can be made extremely small while making the neutralization reaction more active. Furthermore, it is preferable that the granulator is equipped with a chopper to prevent the granulated granules from becoming coarse particles when cooled. That is, by operating the chopper during cooling to regulate the size, the effect of making the diameter of the carbon dioxide gas bubbles smaller than micron size is exhibited, which is a more preferable granulation method.

[0060] In the first neutral bicarbonate bath agent of this embodiment, sodium bicarbonate is granulated with polyethylene glycol using a fluidized bed granulator using a mechanical stirring method, and a certain ratio of organic acid and polyethylene glycol are added to the granulated product, which are then mixed and compressed under high pressure to obtain tablets with a certain hardness and a certain size. Of course, a mixture mainly consisting of organic acid can also be granulated using polyethylene glycol, and bicarbonate is simply mixed with polyethylene glycol without granulation, and then mixed with organic acid granulated product and compressed to obtain tablets. This is preferable as a manufacturing method from the viewpoint of process because the amount of compound to be granulated is relatively small. In any case, from the viewpoint of cost, it is desirable to granulate either bicarbonate or organic acid, and to manufacture the product by simply mixing the other. In addition, in order to maintain the neutralization reaction in the tablet for a long time and increase the amount of carbon dioxide gas dissolved, it is a preferable manufacturing method to use both bicarbonate and organic acid salt mixed or coated with polyethylene glycol.

[0061] In addition, in the first neutral bicarbonate bath additive of this embodiment, it is preferable to add an anhydride in any step before compression molding. If the amount of anhydride is too large, the amount of foaming will be small, while if it is too small, carbon dioxide gas will be generated intensively in the bath, which is not preferable. The anhydride is one or more anhydrides selected from anhydrous sodium carbonate and anhydrous potassium carbonate, and anhydrous sodium carbonate is particularly preferable.

[0062] In addition, the first neutral bicarbonate bath agent of this embodiment can use a release agent for tablet molding. Generally, sucrose or magnesium stearate is used as the release agent, but it is particularly preferable to include one selected from sodium n-(normal)octanesulfonate, sodium laurylsulfonate, sodium lauroylsarcosinate, sodium myristoylmethylalanine, etc., because it allows stable and rapid compression molding of the tablet. In addition, when the tablet is dissolved in hot water, these release agents are most preferably used to cause micro-sized bubbles and maintain the transparency of the hot water after dissolution. The amount of the release agent added may be within the range of known and used, and there is no particular limit.

[0063] In addition to the main component, other components (additives) can be mixed into the first neutral bicarbonate bath agent of this embodiment as needed. Other additives include health components such as hyaluronic acid, fragrances, colorings, vitamin C, and reducing substances that remove chlorine from tap water (sodium ascorbate, amino acids, sodium sulfite, sodium thiosulfate), etc.

[0064] [Second neutral bicarbonate bath additive] The second neutral bicarbonate bath agent used in the bicarbonate bath of this embodiment is a mixture of bicarbonate, organic acid, chlorine neutralizing compound, and lubricant, which is compressed and molded. If necessary, a material such as a water-soluble polymer (hereinafter referred to as a granulation promoter) is added to improve the moldability of the tablet and its solubility in hot water, and the mixture is compressed and molded.

[0065] As the bicarbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, etc. can be used, but sodium hydrogen carbonate is particularly preferred. This sodium hydrogen carbonate (sodium bicarbonate or baking soda) plays a role as a foaming agent, and when it dissolves in hot water together with an organic acid, it foams carbon dioxide through a neutralization reaction, dissociates into bicarbonate ions and hydrogen ions depending on the pH of the dissolution water, and dissolves in the water. This bicarbonate ion exerts the ability to clean mineral sebum dirt in pores, which is the source of so-called odor. The content of bicarbonate in bicarbonate bath additives is specified in relation to other components. If the content is less than the specified amount, the pH when dissolved in hot water will not reach the specified value, and the amount of bicarbonate ions dissolved in hot water will be significantly reduced. On the other hand, if the content exceeds the specified amount, the foaming of carbon dioxide gas will be significantly reduced.

[0066] The organic acid neutralizes bicarbonate and produces carbon dioxide gas effervescence, and when dissolved in hot water, it also has a skin cleansing effect and a skin softening effect. Citric acid, succinic acid, fumaric acid, malic acid, etc. can be used as the organic acid, but citric acid is particularly preferred. When citric acid is used, the neutralization reaction occurs more effectively than when other organic acids are used. The content of the organic acid is specified in relation to the other components as described above. If the content is less than the specified amount, the amount of carbon dioxide gas effervescence during the dissolution of the tablet decreases, the amount of bicarbonate ions dissolved decreases, and the blood flow enhancement effect decreases. On the other hand, if the content exceeds the specified amount, the amount of carbon dioxide gas effervescence increases, but the diameter of the bubbles increases, making it difficult to neutralize the gas, and the amount of bicarbonate ions dissolved decreases.

[0067] As the chlorine neutralizing compound, L-ascorbate, thiosulfate, sulfite, tea catechin, erythorbate, etc. can be used, with L-ascorbate being particularly preferred. As L-ascorbic acid, any known compound can be used without any particular restrictions. As the salt, sodium salt and calcium salt can be mentioned, with sodium salt (sodium L-ascorbate) being particularly preferred. L-ascorbic acid is widely known as vitamin C, and when added to tap water, it can remove chlorine contained in tap water through the reactions shown in the following reaction formulas 1 and 2. In addition, reducing agents such as sodium thiosulfate, thiosulfate, sulfite, and tea catechin can also neutralize and detoxify chlorine through a similar reaction.

[0068] [Reaction 1] C6H8O6 + NaClO → C6H6O6 + H2O + NaCl (Reaction in which vitamin C reduces and removes sodium hypochlorite, which is added for primary sterilization)

[0069] [Reaction 2] C6H8O6 + Cl2 → C6H6O6 + 2HCl (Reaction in which chlorine added to maintain chlorine is removed by vitamin C)

[0070] When ascorbic acid dissolves in tap water through the reactions of reaction formulas 1 and 2, the chlorine contained in the tap water is removed. This prevents the occurrence of problems such as "oxidation, aging, and dandruff" that residual chlorine causes to the skin. In addition, ascorbic acid itself has the effects of increasing skin firmness, preventing fine wrinkles, beautifying the skin, whitening, and anti-aging. As shown in reaction formula 2, a small amount of hydrochloric acid is generated when chlorine is removed, but the pH of the dissolved water is buffered by the buffer effect of bicarbonate ions and organic acids, so the pH of shower water and bath water does not become acidic, and the pH of tap water is stable. The content of this chlorine neutralizing compound is specified in relation to the amount of hot water per tablet of bicarbonate bath additive. If the content is less than the specified amount, the chlorine contained in tap water cannot be sufficiently removed. On the other hand, even if the content is added to a level greater than the specified amount, there is no chlorine to be removed, and the chlorine neutralizing compound is wasted.

[0071] The lubricant is a substance that improves the flowability, compressibility, etc. of the powder. As the lubricant, at least one selected from an alkane sulfonate having 6 to 18 carbon atoms, an olefin sulfonate, and a sucrose fatty acid ester can be used, and in particular, the alkane sulfonate having 6 to 18 carbon atoms and / or the olefin sulfonate is preferably at least one selected from sodium alkane sulfonate having 14 to 18 carbon atoms, sodium tetradecene sulfonate, and sodium normal octane sulfonate.

[0072] The granulation promoter plays the role of compressing and molding materials such as bicarbonate, organic acid, and chlorine neutralizing compound to produce tablets, of making tablets more soluble in hot water, and of dissolving carbon dioxide gas components as bicarbonate ions to the maximum extent when the tablets are dissolved in hot water. As with the first neutral bicarbonate bath additive, polyethylene glycol (PEG) can be used as the granulation promoter, and PEG6000 is particularly preferred. In addition, polyethylene glycol is produced using solvents such as ethylene oxide, which is a carcinogenic substance, and 1,4-dioxane, which is suspected to be carcinogenic, and there is concern that it may be contaminated by these solvents. In addition, polyethylene glycol is also concerned about causing allergies because it remains in the body for a long time. As an alternative to polyethylene glycol, for example, polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, magnesium sulfate, sodium sulfate, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, dextran, etc. can be used. The content of the granulation promoter is specified in relation to the other components as described above. If the content is less than the specified amount, the diameter of the carbon dioxide bubbles will be large and the foaming time will be short, and the amount of carbon dioxide that dissolves in the hot water will not be increased. On the other hand, if the content exceeds the specified amount, the amount of bubbles generated will be suppressed, and similarly, the amount of carbon dioxide that dissolves in the hot water will be reduced.

[0073] Next, a method for producing the second neutral bicarbonate bath additive using these materials will be described.

[0074] The second method for producing neutral bicarbonate bath additives includes (1) preparing a granulated product of bicarbonate (coating the bicarbonate with a granulation accelerator, if necessary, to prepare granulated product) and mixing the granulated product with a mixture of an organic acid, a chlorine neutralizing compound, and a lubricant; (2) preparing a granulated product of an organic acid (coating the organic acid with a granulation accelerator, if necessary, to prepare granulated product) and mixing the granulated product with a mixture of bicarbonate, a chlorine neutralizing compound, and a lubricant; and (3) preparing a granulated product of bicarbonate (coating the bicarbonate with a granulation accelerator, if necessary, to prepare granulated product) and a granulated product of an organic acid (coating the organic acid with a granulation accelerator, if necessary, to prepare granulated product) and mixing the chlorine neutralizing compound and a lubricant with the granulated product.

[0075] Either method can be used to produce the second neutral bicarbonate bath additive that exerts the effect of bicarbonate ions, but method (1) is preferable as a method for producing the second neutral bicarbonate bath additive, since it can maximize the amount of carbon dioxide gas dissolved in the hot water by foaming micro-sized bubbles for a long period of time and can also greatly reduce the number of steps, i.e., the method of producing a granulated product of bicarbonate (here, the granulated product is produced by coating the bicarbonate with a granulation promoter) and then mixing the granulated product with a mixture of an organic acid, a chlorine neutralizing compound, and a lubricant. The following explanation will be based on this method.

[0076] First, the bicarbonate is coated with a granulation promoter to prepare a granulated material. In this embodiment, sodium hydrogen carbonate is used as the bicarbonate, and PEG6000 is used as the granulation promoter. According to the experiments of the present inventors, by setting the weight ratio of the granulation promoter to the bicarbonate at 1 / 50 to 1 / 8, the capillaries can be expanded to twice the size, and the blood flow can be increased by more than five times at once.

[0077] Next, a mixture of an organic acid, a chlorine neutralizing compound, and a lubricant is prepared. In this embodiment, citric acid is used as the organic acid, sodium L-ascorbate is used as the chlorine neutralizing compound, and sodium tetradecene sulfonate and sodium octanesulfonate are used as the lubricants. According to the experiments of the present inventor, by setting the weight ratio of the organic acid to the bicarbonate to 1 / 8 to 2 / 7 and the weight ratio of the chlorine neutralizing compound to the tablet to 1 / 1500 to 1 / 30, the capillaries can be expanded to double size and the blood flow can be increased by more than 5 times at once. In addition, when the mixture of the organic acid, the chlorine neutralizing compound, and the lubricant is not granulated, it is not necessary to add a granulation promoter, but a granulation promoter may be added to improve tableting properties.

[0078] Next, the mixture (organic acid, chlorine neutralizing compound, and lubricant) is mixed with the granulated material (bicarbonate and granulation promoter) and compressed to produce tablets. A known compression molding machine can be used for the compression molding to produce tablets, but for example, a hydraulic press, a single punch tablet press, a rotary tablet press, a briquetting machine, etc. can also be used.

[0079] During this compression molding, the tablet hardness (here, breaking strength) is set to a predetermined value or more. The higher the hardness, the more effectively carbon dioxide gas is generated in the tablet, the more efficiently the carbon dioxide gas dissolves in the hot water, and the finer the bubbles become, resulting in favorable results. According to experiments by the present inventors, by making the tablet hardness 20kgf or more, the capillaries can be expanded to double their size, and blood flow can be increased five-fold or more in one go. This diametric breaking strength (kgf) can be measured using a digital tablet hardness tester New Speed ​​Checker TS75NL manufactured by Okada Seiko Co., Ltd.

[0080] In the second neutral bicarbonate bath additive, an anhydride such as anhydrous sodium carbonate, anhydrous potassium carbonate, anhydrous calcium carbonate, or anhydrous magnesium carbonate may be added. By adding an anhydride, the bubble size of the carbon dioxide gas can be made optimally small while the foaming amount can be made larger and last for a long time, and the above effect can be particularly notable when anhydrous sodium carbonate is added as the anhydride. This anhydride can be added at any step before compression molding, such as the step of preparing a granule or the step of mixing the granule with a mixture, but it is preferable to add the anhydride at the stage of mixing the mixture of an organic acid, a chlorine neutralizing compound, and a lubricant with the granule of bicarbonate, and in particular, it is most preferable to simultaneously add the organic acid, the chlorine neutralizing compound, the lubricant, and the anhydride after cooling the granule, mix them, and immediately tablet them. If the amount of the anhydride is too large, the amount of foaming bubbles will be reduced, while if the amount is too small, carbon dioxide gas will be generated in the bath water intensively, which is not preferable.

[0081] In addition, the second neutral bicarbonate bath agent can use a release agent for tablet molding. As the release agent, sucrose, magnesium stearate, etc. are generally used, but magnesium stearate is the most preferable because it can stably and continuously compress and mold tablets at high speed. Furthermore, other ingredients can be mixed into the bicarbonate bath agent as necessary. Other ingredients include health ingredients such as hyaluronic acid, fragrances, colorants, surfactants, etc.

[0082] The present invention is not limited to the above-described embodiment, and the configuration can be modified as appropriate without departing from the spirit of the present invention.

[0083] For example, in the first neutral bicarbonate bath additive in the above example, the bathing conditions were described when the tablet invented by the inventors of the present application was used as the neutral bicarbonate bath additive. However, as shown in the second neutral bicarbonate bath additive, the bathing method for preparing for sleep of the present invention can be similarly applied even if another tablet that can dissolve bicarbonate ions to the same extent in hot water is used as the bath additive. [Industrial Applicability]

[0084] INDUSTRIAL APPLICABILITY The present invention can be used as a bathing method for preparing for sleep by bathing in hot water having dissolved bicarbonate ions. [Explanation of symbols]

[0085] 1 epidermis 2 Dermis / subcutaneous adipose tissue 3 Pores 4. Sweat pores 5 blood vessels 6 Blood vessel wall 7 Smooth Muscle 8 Vascular endothelial cells 9 Intravascular

Claims

1. A bathing method for preparing for sleep, in which a person takes a bath in hot water containing dissolved bath additives, comprising: The bath additive contains a bicarbonate salt, which is sodium bicarbonate or potassium bicarbonate, and an organic acid as a composition, and the mixing ratio of the composition is set so that hot water containing the bath additive dissolved therein becomes substantially neutral; The bather takes a bath under conditions that make the bather's deep body temperature approximately 0.2°C higher than when bathing in normal hot water. Finish the bathing approximately 60 to 120 minutes before the expected time to fall asleep. A bathing method for preparing for sleep.

2. Continue bathing under the above bathing conditions for at least one week.

2. The bathing method for preparing for sleep according to claim 1.

3. The bathing conditions are that the temperature of the hot water is 29 to 43° C., the concentration of bicarbonate ions dissolved in the hot water is 0.1 to 10 mmol / L, and the bathing time is 10 minutes or more.

3. The bathing method for preparing for sleep according to claim 1 or 2.

4. The bathing conditions are that the temperature of the water is 32 to 40° C., the concentration of bicarbonate ions dissolved in the water is 0.2 to 5 mmol / L, and the bathing time is 20 minutes or more.

3. The bathing method for preparing for sleep according to claim 1 or 2.

5. The bath additive comprises a chlorine neutralizing compound and a lubricant, The bicarbonate is sodium hydrogen carbonate, The organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid; the chlorine-neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate; The lubricant is at least one selected from the group consisting of alkanesulfonates having 6 to 18 carbon atoms, olefinsulfonates, and sucrose fatty acid esters; the weight ratio of the organic acid to the bicarbonate is 1 / 8 to 2 / 7; The weight ratio of the chlorine neutralizing compound to the tablet is 1 / 1500 to 1 / 30; The hardness of the tablet is 20 kgf or more.

3. The bathing method for preparing for sleep according to claim 1 or 2.

6. The bath agent contains a granulation promoter, the granulation promoter is at least one selected from polyethylene glycol, polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, magnesium sulfate, sodium sulfate, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran; The weight ratio of the granulation enhancer to the bicarbonate is 1 / 50 to 1 / 8.

6. The bathing method for preparing for sleep according to claim 5.

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