Topical skin agent

Abstract

To provide a topical skin agent which exhibits a synergistically enhanced moisturizing effect through the combined use of specific components.SOLUTION: The present invention provides a topical skin agent comprising the following components (A) to (C): (A) bakuchiol, (B) glyceryl glucoside, and (C) one or more selected from rice fermentation liquid, niacinamide, and hydrolyzed collagen.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] In recent years, technological developments have been made to combine various ingredients to increase the added value of topical skin preparations. Generally, a wide range of functions are required for topical skin preparations, but in the past, various moisturizing agents have been considered and included to increase the moisturizing effect, and studies have been conducted to further improve the effect by combining ingredients, etc. (Reference 1).

[0003] However, the effects of the combination are unpredictable, as the effects are not synergistically improved by simply using them together, but are additively improved or offset. In particular, there is a high demand for ingredients that can provide higher effects in smaller amounts in topical skin preparations. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent Publication No. 2021-123540 Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide an external skin preparation which, by using specific ingredients in combination, exhibits a synergistically improved moisturizing effect. [Means for solving the problem]

[0006] The means for solving the problems of the present invention is to provide an external skin preparation containing the following (A) to (C): (A) Bactiol (B) Glyceryl glucoside (C) one or more selected from rice fermentation liquid, niacinamide, and hydrolyzed collagen Effect of the Invention

[0007] The skin external preparation of the present invention exerts a synergistically improved moisturizing effect by using specific ingredients in combination. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] Hereinafter, an embodiment of the present invention will be described.

[0009] Component (A) [Bactiol] Bactiol used in the present invention is a component contained in the seeds of Psoralea corylifolia, which is classified into the genus Psoralea in the family Fabaceae, and is a compound with CAS number 10309-37-2.

[0010] Bactiol can be naturally derived or synthetic.

[0011] The amount of bactiol in the topical skin preparation of the present invention is preferably 0.00001 to 5 mass %, more preferably 0.00005 to 3 mass %, based on the total amount of the topical skin preparation.

[0012] Ingredient (B) [Glyceryl glucoside] The glyceryl glucoside used in the present invention may be produced by any method, such as synthesis or fermentation by microorganisms, so long as it can be generally incorporated into cosmetics and the like. Specifically, either the α-form, the β-form, or a mixture thereof may be used. Commercially available products include Glycoin (registered trademark) natural (manufactured by Bitop AG) and COSARTE-2G (registered trademark) (manufactured by Toyo Sugar Refining Co., Ltd.). Commercially available products containing glyceryl glucoside include Vivendin (manufactured by Evonik Operations GmbH).

[0013] The amount of glyceryl glucoside in the skin topical preparation of the present invention is preferably 0.0001 to 5% by mass, more preferably 0.0005 to 3% by mass, based on the total amount of the skin topical preparation. If the amount of glyceryl glucoside is less than 0.0001% by mass, sufficient moisturizing effect may not be obtained. If the amount of glyceryl glucoside is more than 5% by mass, stickiness may occur.

[0014] Ingredients (C) [Rice fermentation liquid] The rice fermentation liquid used in the present invention is obtained by enzymatic decomposition or saccharification with koji, and fermentation with yeast or yeast starter. Commercially available products include Kome Extract Koken MPN (manufactured by Koken Co., Ltd.), ASFERMPLUS (manufactured by SKbioland Co., Ltd.), and Horus Ginjo Extract AL (manufactured by Horus Co., Ltd.).

[0015] When the rice fermentation liquid is blended in the skin external preparation of the present invention, the blending amount is preferably 0.0001 to 10% by mass, more preferably 0.001 to 5% by mass, based on the total amount of the skin external preparation. If the blending amount is less than 0.0001% by mass, sufficient moisturizing effect may not be obtained. If the blending amount of the rice fermentation liquid is blended in an amount exceeding 10% by mass, the amino acids contained as the components may precipitate or coloration may be observed over time.

[0016] [Niacinamide] Niacinamide used in the present invention is one of the B vitamins, which are water-soluble vitamins, and is also called nicotinamide.

[0017] Niacinamide used in the present invention can be used as a raw material for topical skin preparations. The materials, production methods, purification methods, etc. are not particularly limited.

[0018] The amount of niacinamide in the skin external preparation of the present invention is preferably 0.1 to 20% by mass, more preferably 1 to 10% by mass, based on the total amount of the skin external preparation. If the amount is less than 0.1% by mass, sufficient moisturizing effect may not be obtained. If the amount is more than 20% by mass, the skin external preparation may feel sticky.

[0019] [Hydrolyzed collagen] The hydrolyzed collagen used in the present invention is a hydrolyzate obtained by hydrolyzing collagen by a known method. Here, the type of collagen is not particularly limited, and any of types I to XIII or a mixture of types can be used. The origin of collagen can be selected from animals (e.g., cows, pigs, chickens, etc.) and fish (e.g., cod, salmon, tuna, tilapia, etc.) and the extraction site can be selected from bones, skin, tendons, swim bladder (fish), scales (fish), etc. Conventionally known methods include, for example, a method of acid decomposition in an aqueous solution, a method of alkali decomposition, a method of enzymatic decomposition, etc. In addition, commercially available products can be used as they are, for example, "MCM-N1" (manufactured by Yamakawa Trading Co., Ltd.), "Promois (registered trademark)" series (manufactured by Seiwa Kasei Co., Ltd.), TYPE-S Cosme (PF) (manufactured by Nitta Gelatin Co., Ltd.), etc.

[0020] The average molecular weight of the hydrolyzed collagen is not particularly limited, but is preferably 100 to 5,000. When the average molecular weight is 100 or more, a desired moisturizing feeling can be obtained. When the average molecular weight is 5,000 or less, stickiness and filmy feeling during use can be reduced. Here, the average molecular weight can be determined, for example, by a gel filtration method using high performance liquid chromatography.

[0021] When hydrolyzed collagen is incorporated into the skin topical preparation of the present invention, the amount of hydrolyzed collagen is preferably 0.0001 to 10% by mass, more preferably 0.0005 to 5% by mass, based on the total amount of the skin topical preparation. If the amount is less than 0.0001% by mass, sufficient moisturizing effect may not be obtained. If the amount is more than 10% by mass, the skin topical preparation may feel sticky when used.

[0022] As component (C), one or more selected from rice fermentation liquid, niacinamide, and hydrolyzed collagen are used. From the viewpoint of moisturizing effect, it is preferable to use rice fermentation liquid alone or two types of niacinamide and hydrolyzed collagen in combination as component (C). It is also preferable to use three types of rice fermentation liquid, niacinamide, and hydrolyzed collagen in combination.

[0023] In addition to the above-mentioned components, the skin topical preparation of the present invention may contain optional components used in ordinary cosmetics and quasi-drugs to the extent that the effects of the present invention are not impaired.Specific examples of such components include oils, surfactants, thickeners, preservatives, fragrances, moisturizers, antioxidants, anti-inflammatory agents, and antibacterial agents.

[0024] The formulation of the external skin preparation of the present invention is not particularly limited, and may be any formulation such as water-based, oil-based, or emulsion-type.

[0025] The skin external preparation of the present invention can be prepared by a conventional method.

[0026] The skin external preparation of the present invention can be used in the form of, for example, a lotion, emulsion, or ointment. EXAMPLES

[0027] The present invention will be described in detail below with reference to examples, but the scope of the present invention is not limited thereto. The blend amounts are in mass % unless otherwise specified.

[0028] [Moisturizing effect test method] The samples shown in Table 1 were prepared and the moisture content of the skin's stratum corneum and the amount of transepidermal water loss were measured. Note that the samples were mixed with polyoxyethylene hydrogenated castor oil and ethanol to disperse bactiol.

[0029] [Measurement method] (1) Acclimation After washing the inside of the left and right forearms of each subject, the subjects wiped off any moisture and then rested for 15 minutes in a room adjusted to a temperature of 21±0.5°C and humidity of 50±5% to allow for acclimation. (2) Coating A 3 cm x 3 cm area was marked on the inside of the left and right forearms, and 9 μL was dropped using a pipette and applied evenly with a finger wearing a finger cot. (3) Measurement The moisture content of the stratum corneum was measured before application and 2 hours after application using a SKICON-200EX (Yayoi). The transepidermal water loss was measured before application, 1 hour after application, and 2 hours after application using a Vapometer (SWL4081) (Delphin Technologies). The moisture content of the stratum corneum and the transepidermal water loss were calculated as relative values ​​with the value before application set as 1, and are shown in Table 1. The moisture content of the stratum corneum and the transepidermal water loss are easily affected by the temperature and humidity on the day of measurement, so a group of samples were evaluated on the same day, and the measurement value at the site where the sample was applied was used as the standard for relative values ​​before application.

[0030] [Table 1]

[0031] As shown in Table 1, in Example 1, the moisture content of the skin's epidermis was improved and the transepidermal water loss was reduced, even though the amount of each component was one-third that of Comparative Examples 1 to 3, which used each component alone. In addition, in Example 2, the moisture content of the skin's epidermis was improved and the transepidermal water loss was reduced, even though the amount of each component was one-quarter that of Comparative Examples 1, 2, 4, and 5, which used each component alone. Thus, the skin topical preparation of the present invention exerted an effect of synergistically improving the moisturizing effect.

[0032] [Example 3] Cream (1) Squalane 10.0 (mass%) (2) Stearic acid 2.0 (3) Hydrogenated palm kernel oil 0.5 (4) Hydrogenated soybean phospholipid 0.1 (5) Cetanol 3.6 (6) Bactiol 0.2 (7) Lipophilic glyceryl monostearate 2.0 (8) Glycerin 10.0 (9) Glyceryl glucoside (Note 1) 1.5 (10) Rice fermentation liquid (Note 2) 1.2 (11) Phenoxyethanol 0.2 (12) Arginine (20% by weight aqueous solution) 15.0 (13) Sodium hyaluronate 0.05 (14) Purified water (total amount: 100) (15) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0

[0033] [Example 4] Emulsion (1) Squalane 10.0 (mass%) (2) Methylphenylpolysiloxane 4.0 (3) Hydrogenated palm kernel oil 0.5 (4) Bactiol 0.01 (5) Hydrogenated soybean phospholipid 0.1 (6) Polyoxyethylene monostearate Sorbitan (20 E.O.) 1.3 (7) Sorbitan monostearate 1.0 (8) Glycerin 4.0 (9) Glyceryl glucoside (Note 1) 0.01 (10) Niacinamide 6.0 (11) Phenoxyethanol 0.2 (12) Carboxyvinyl polymer (1% by weight aqueous solution) 10.0 (13) Sodium hyaluronate 0.001 (14) Purified water (total amount: 100) (15) L-arginine (1% by weight aqueous solution) 20.0

[0034] [Example 5] Lotion (1) Ethanol 15.0 (mass%) (2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3 (3) Bactiol 0.001 (4)Fragrance 0.1 (5) Purified water (total amount: 100) (6) Citric acid 0.02 (7) Sodium citrate 0.1 (8) Glycerin 1.0 (9) Glyceryl glucoside (Note 1) 1.0 (10) Hydrolyzed collagen (Note 3) 1.0 (11) Hydroxyethyl cellulose 0.1 (12) Sodium hyaluronate 0.003

[0035] [Example 6] Cosmetic essence (1) Purified water (mass%) (2) Glycerin 10.0 (3) Sucrose fatty acid ester 1.3 (4) Carboxyvinyl polymer (1% by weight aqueous solution) 17.5 (5) Sodium alginate (1% by weight aqueous solution) 15.0 (6) Polyglyceryl monolaurate 1.0 (7) Sodium hyaluronate 0.001 (8) Glyceryl glucoside (Note 1) 3.0 (9) Rice fermentation liquid (Note 2) 1.0 (10) Niacinamide 3.5 (11) Hydrolyzed collagen (Note 3) 2.0 (12) Phytosteryl Macadamiate 3.0 (13) N-Lauroyl-L-glutamic acid Di(phytosteryl-2-octyldodecyl) 2.0 (14) Hydrogenated palm oil 2.0 (15) Squalane (derived from olives) 1.0 (16) Behenyl alcohol 0.75 (17) Beeswax 1.0 (18) Jojoba oil 1.0 (19) Bactiol 0.05 (20) 1,3-butylene glycol 10.0 (21) L-arginine (10% by weight aqueous solution) 2.0

[0036] [Example 7] Water-based gel (1) Carboxyvinyl polymer 0.5 (mass%) (2) Purified water (total amount = 100) (3) Sodium hydroxide (10% by weight aqueous solution) 0.5 (4) Phenoxyethanol 0.2 (5) Glyceryl glucoside (Note 1) 0.001 (6) Niacinamide 1.0 (7) Hydrolyzed collagen (note 3) 0.01 (8) Polyoxyethylene (60E.O.) hydrogenated castor oil 0.1 (9) Bactiol 0.0001 (10)Fragrance 0.01

[0037] [Example 8] Makeup base cream (1) Squalane 10.0 (mass%) (2) Cetanol 2.0 (3) Glycerol tri-2-ethylhexanoate 2.5 (4) Lipophilic glyceryl monostearate 1.0 (5) Propylene glycol 11.0 (6) Sucrose fatty acid ester 1.3 (7) Purified water (total amount = 100) (8) Titanium dioxide 1.0 (9) Bengala 0.1 (10) Yellow iron oxide 0.4 (11)Fragrance 0.1 (12) Bactiol 1.0 (13) Glyceryl glucoside (Note 1) 0.1 (14) Rice fermentation liquid (Note 2) 0.2 (15) Niacinamide 1.0

[0038] [Example 9] Lotion (1) Ethanol 10.0 (mass%) (2) Phenoxyethanol 0.1 (3) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3 (4) Bactiol 0.05 (5)Fragrance 0.1 (6) Purified water (total amount: 100) (7) Citric acid 0.02 (8) Sodium citrate 0.1 (9) Glycerin 3.0 (10) Glyceryl glucoside (Note 1) 0.05 (11) Rice fermentation liquid (Note 2) 3.0 (12) Hydrolyzed collagen (note 3) 0.01 (13) Hydroxyethyl cellulose 0.1

Claims

[Claim 1] A skin topical preparation comprising the following (A) to (C): (A) Bakuchiol (B) Glyceryl glucoside (C) one or more selected from rice fermentation liquid, niacinamide, and hydrolyzed collagen

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