Topical skin preparation

Abstract

To provide a topical skin preparation having excellent dispersibility and stability.SOLUTION: A topical skin preparation of the present invention comprises a cannabinoid and a sucrose fatty acid ester, wherein the sucrose fatty acid ester has an average degree of esterification of 1.00 to 1.15.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an external skin preparation containing a cannabinoid. [Background technology]

[0002] Cannabinoids are contained in the leaves and seed coats of hemp plants, and are known to contain various components such as cannabidiol (CBD). Cannabidiol has unique effects and is widely used in the food industry, such as food additives, and in the medical industry, such as pharmaceuticals, making it a highly useful component. Summary of the Invention [Means for solving the problem]

[0003] As a result of intensive research, the inventors discovered that by using cannabinoids and specific sucrose fatty acid esters as essential ingredients in topical skin preparations, the preparations have excellent dispersibility and stability, and thus completed the present invention.

[0004] That is, the present invention includes, for example, the subject matter described in the following sections. Item 1 1. An external skin preparation comprising a cannabinoid and a sucrose fatty acid ester, wherein the sucrose fatty acid ester has an average degree of esterification of 1.00 to 1.15. Effect of the Invention

[0005] According to the present invention, an external skin preparation having excellent dispersibility and stability can be obtained. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0006] Hereinafter, embodiments of the present invention will be described in detail. In this specification, the expressions "containing" and "comprise" include the concepts of "containing", "comprises", "consists essentially of" and "consists only of".

[0007] The skin topical preparation of the present invention contains a cannabinoid and a sucrose fatty acid ester, and the sucrose fatty acid ester has an average degree of esterification of 1.00 to 1.15. Since the skin topical preparation of the present invention contains the specific sucrose fatty acid ester, it has excellent dispersibility and storage stability.

[0008] As the cannabinoid contained in the topical skin preparation of the present invention, for example, one or more of the various compound groups contained in cannabinoids derived from cannabis (specifically, cannabidiol (CBD), tetrahydrocannabinol, etc.) can be used.

[0009] The cannabinoid preferably contains cannabidiol. In this case, the dispersibility in a solvent, particularly an aqueous solvent, is particularly excellent. The cannabinoid preferably contains 50% by mass or more of cannabidiol, more preferably 80% by mass or more, even more preferably 90% by mass or more, and particularly preferably 95% by mass or more. The cannabinoid may be only one kind of cannabidiol.

[0010] Cannabinoid can be produced, for example, by known methods. Alternatively, commercially available cannabinoid can be applied to the skin external preparation of the present invention.Similarly, cannabidiol can be produced, for example, by known methods, or commercially available cannabidiol can be applied to the skin external preparation of the present invention.

[0011] The content of the cannabinoid in the external skin preparation of the present invention is not particularly limited, but is preferably, for example, 0.00001 to 5 mass %, and more preferably 0.001 to 3 mass %.

[0012] As described above, the sucrose fatty acid ester contained in the skin external preparation of the present invention has an average esterification degree in the range of 1.00 to 1.15. In other words, the average esterification degree of the sucrose fatty acid ester is 1.00 or more and 1.15 or less. As a mere precaution, in this specification, the term "sucrose fatty acid ester" refers to a compound formed by an esterification reaction between sucrose and a fatty acid.

[0013] By including a sucrose fatty acid ester having an average degree of esterification of 1.00 to 1.15 in the topical skin preparation, the dispersibility of the cannabinoid in the solvent is excellent, and the storage stability of the topical skin preparation is excellent.

[0014] The average degree of esterification of the sucrose fatty acid ester is preferably 1.01 or more, and more preferably 1.12 or less, more preferably 1.10 or less, and particularly preferably 1.08 or less.

[0015] In the present invention, the average degree of esterification of sucrose fatty acid esters can be calculated as the average degree of esterification X of sucrose fatty acid esters by the following formula (1). (Ns-X)=(Nx) / (Ny) ={(OHV) / (1000×56.11)} / {1 / (MwSug+(MwFa-18)X)} (1)

[0016] Here, the meanings of the symbols in formula (1) are as follows: Ns: number of OH groups in one sucrose molecule Nx: Number of moles of OH groups in 1 g of sample (sucrose fatty acid ester) Ny: number of moles of sucrose fatty acid ester in 1 g of sample OHV: Hydroxyl value of sucrose fatty acid ester MwSug: Molecular weight of sucrose MwFa: average molecular weight of constituent fatty acids

[0017] X can be calculated by substituting known values ​​of Ns, Nx, Ny, OHV, MwSug, and MwFa into the above formula (1). Note that Ns, Nx, Ny, OHV, MwSug, and MwFa can be measured by known methods.

[0018] As can be seen from the above method for calculating the average degree of esterification, the sucrose fatty acid ester in the present invention can be said to be an aggregate of sucrose fatty acid ester molecules having different degrees of esterification.

[0019] When a commercially available sucrose fatty acid ester is used in the skin topical preparation of the present invention, the value disclosed by the manufacturer, such as the manufacturer's guaranteed value or catalog value of the sucrose fatty acid ester, can be used as the average degree of esterification.

[0020] The type of sucrose fatty acid ester is not particularly limited as long as the average degree of esterification is within the above-mentioned range, and for example, a wide variety of known sucrose fatty acid esters can be applied to the external skin preparation of the present invention.

[0021] In the sucrose fatty acid ester, the type of the fatty acid moiety (RCOO-moiety) of the sucrose fatty acid ester is not particularly limited. The fatty acid moiety of the sucrose fatty acid ester may be a moiety derived from a saturated fatty acid or a moiety derived from an unsaturated fatty acid, and is preferably derived from a saturated fatty acid.

[0022] In the sucrose fatty acid ester, the number of carbon atoms in the fatty acid moiety of the sucrose fatty acid ester is not particularly limited, and for example, from the viewpoint of easily increasing the dispersibility of the cannabinoid, the number of carbon atoms in the fatty acid moiety (including ester carbon) is preferably 30 or less, more preferably 25 or less, even more preferably 20 or less, and particularly preferably 18 or less. In addition, from the viewpoint of easily increasing the dispersibility of the cannabinoid, the number of carbon atoms in the fatty acid moiety (including ester carbon) is preferably 8 or more, more preferably 10 or more, even more preferably 12 or more, and particularly preferably 14 or more. The fatty acid moiety in the sucrose fatty acid ester is preferably derived from, for example, lauric acid, palmitic acid, stearic acid, etc.

[0023] Sucrose fatty acid esters include monoesters, diesters, and triesters. The sucrose fatty acid esters contained in the skin topical preparation of the present invention may be any of these esters, and may contain not only one, but also two or all of the esters. In other words, the sucrose fatty acid esters may contain one or more sucrose fatty acid esters selected from the group consisting of monoesters, diesters, and triesters.

[0024] The method for producing the sucrose fatty acid ester is not particularly limited, and for example, any known production method can be widely adopted. For example, the sucrose fatty acid ester can be synthesized by transesterification of sucrose and fatty acid ester. The fatty acid ester can be a methyl ester of fatty acid.

[0025] Sucrose used in the method for producing sucrose fatty acid esters may be synthesized by a known method, or sucrose may be available from a commercial product. Sucrose may be unreacted sucrose recovered during the production of sucrose fatty acid esters (so-called "recovered sugar"). Sucrose may be in a solid state or in a solution state dissolved in a solvent. Fatty acids used in the method for producing sucrose fatty acid esters may be synthesized by a known method, or fatty acids may be available from a commercial product.

[0026] The method for adjusting the average esterification degree of the sucrose fatty acid ester is not particularly limited, and for example, known methods can be widely adopted. For example, the average esterification degree of the obtained sucrose fatty acid ester can be controlled within a desired range by adjusting various synthesis conditions such as the ratio of sucrose and fatty acid or its ester used in the production of the sucrose fatty acid ester, the type of fatty acid, and the esterification reaction conditions.

[0027] Alternatively, the average degree of esterification of the sucrose fatty acid ester may be controlled to a desired range by mixing two or more sucrose fatty acid esters having different average degrees of esterification, in which case the average degree of esterification of each sucrose fatty acid ester can be easily adjusted to a desired range based on the degree of esterification of each sucrose fatty acid ester and the mixing mass ratio.

[0028] In the topical skin preparation of the present invention, the content of the sucrose fatty acid ester is not particularly limited, but is, for example, preferably 0.01 to 30 mass%, more preferably 0.1 to 20 mass%, and even more preferably 0.5 to 15 mass%.

[0029] The ratio of cannabinoid to sucrose fatty acid ester in the topical skin preparation of the present invention is not particularly limited, but for example, when the total mass of the cannabinoid in the topical skin preparation is 100 parts by mass, the content of sucrose fatty acid ester is preferably 100 parts by mass or more, more preferably 300 parts by mass or more, even more preferably 500 parts by mass or more, and particularly preferably 600 parts by mass or more, and is preferably 5000 parts by mass or less, more preferably 3000 parts by mass or less, even more preferably 2000 parts by mass or less, and particularly preferably 1500 parts by mass or less.

[0030] The topical skin preparation of the present invention can contain one or more sucrose fatty acid esters.

[0031] The topical skin preparation of the present invention may be a cosmetic, a quasi-drug, or a topical medicine, and examples thereof include milky lotion, cream, lotion, essence, pack, lipstick, foundation, sheet mask, liquid foundation, makeup press powder, blusher, face powder, facial cleanser, body shampoo, hair shampoo, soap, bath additives, etc.

[0032] The skin external preparation of the present invention may contain various additives that are widely used in pharmaceutical applications. Examples of such additives include solvents, surfactants other than the sucrose fatty acid esters, oily components, moisturizers, thickeners, emulsifiers / emulsifier assistants, preservatives / bactericides, powder components, UV absorbers, antioxidants, anti-inflammatory agents, cell activators, etc. In addition, the skin external preparation of the present invention may contain pigments, fragrances, anti-wrinkle agents, whitening agents, bioactive ingredients, etc., within the scope of not impairing the effects of the present invention.

[0033] The solvent may be an aqueous solvent or an oil-based solvent, with an aqueous solvent being preferred. The aqueous solvent may be, for example, water or an alcoholic component. The alcoholic component may be lower alcoholic compounds such as methanol, ethanol, isopropanol, or polyhydric alcoholic compounds such as glycerin.

[0034] Examples of the surfactant other than the sucrose fatty acid ester include a wide variety of known surfactants, such as nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitol fatty acid esters, fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates, polyoxyethylene alkyl ether phosphates, and α-sulfonated fatty acids. Examples of such surfactants include anionic surfactants such as alkyl ester salts and polyoxyethylene alkyl phenyl ether phosphates; cationic surfactants such as quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorpholinium salts and polyethylene polyamine fatty acid amide salts; and amphoteric surfactants such as N,N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N,N,N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidopropyl-N' and N'-dimethyl-N'-β-hydroxypropylammoniosulfobetaine.

[0035] Examples of oily components include vegetable oils and fats such as olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cacao oil, meadowfoam oil, shea butter, tea tree oil, avocado oil, macadamia nut oil, bergamot oil, lavender oil, rose oil, bergamot oil, chamomile oil, cottonseed oil, castor oil, and soybean oil; animal oils and fats such as lard, beef tallow, milk fat, fish oil, mink oil, and turtle oil; isopropyl riscited, palmitate, and the like. synthetic fats and oils such as isopropyl phosphate, butyl oleate, 2-ethylhexyl glyceride, octyldodecyl stearate and MCT oil; waxes such as beeswax, carnauba wax, rice wax and lanolin; hydrocarbons such as liquid paraffin, petrolatum, paraffin wax, squalane and squalene; lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, elaidic acid and cis-11- Examples of suitable silicones include fatty acids such as eicosenoic acid, higher alcohols such as lauryl alcohol, cetanol, pantothenyl alcohol, and stearyl alcohol, methyl polysiloxane, methylphenyl polysiloxane, decamethylcyclopentasiloxane, methyl hydrogen polysiloxane, methyl trimethicone, dimethiconol, dimethiconol crosspolymer, caprylyl methicone, crosslinked alkyl modified silicone, amino modified silicone, polyether modified silicone, polyglycerin modified silicone, crosslinked polyether modified silicone, crosslinked alkyl polyether modified silicone, silicone / alkyl chain co-modified polyether modified silicone, silicone / alkyl chain co-modified polyglycerin modified silicone, polyether modified branched silicone, polyglycerin modified branched silicone, acrylic silicone, phenyl modified silicone, and silicone resin.

[0036] Examples of moisturizing agents include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and the like, as well as sugars such as trehalose and raffinose, mucopolysaccharides (e.g., hyaluronic acid and its derivatives, hyaluronic acid fermentation liquid, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, collagen peptides, NMF-related substances, lactic acid, urea, higher fatty acids octyldodecyl, seaweed extracts, estradiol, various amino acids and their derivatives.

[0037] Examples of thickening agents include components derived from brown algae, green algae, or red algae, such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as pectin and aloe polysaccharides; gums such as tragacanth gum, locust bean gum, xanthan gum, and guar gum; cellulose derivatives such as carboxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl cellulose; synthetic polymers such as carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers, polyvinyl alcohol, polyvinylpyrrolidone, and acrylic acid-methacrylic acid copolymers; hyaluronic acid and its derivatives, polyglutamic acid and its derivatives, and polyacrylic acid.

[0038] Examples of emulsifiers and emulsifier aids include stevia derivatives such as enzyme-treated stevia, saponin or its derivatives, casein or its salts (sodium, etc.), sugar and protein complexes, sucrose or its esters, lactose, water-soluble polysaccharides derived from soybeans, soybean-derived protein and polysaccharide complexes, lanolin or its derivatives, cholesterol, stevia derivatives (enzyme-treated stevia, etc.), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.), saponin and its derivatives, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, and lactic acid bacteria-fermented grains (wheat, beans, millet, etc.).

[0039] Examples of preservatives and disinfectants include urea; benzoic acid or its salts, parahydroxybenzoic acid esters such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and butyl parahydroxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzethonium chloride, cetylpiperidine chloride, benzalkonium chloride, salicylic acid, sodium salicylate, zinc pyrithione, ethanol, undecylenic acid, and phenol. Examples of such extracts include alkyl isoquinolinium bromide, resorcinol, jamal (imidazolidinyl urea), isopropyl methylphenol, triclosan, trichlorocarbanide, trichlorohydroxydiphenol ether, hinokitiol, 1,2-pentanediol, propanediol, concentrated benzalkonium chloride solution 50, essential oils such as peppermint oil and eucalyptus oil, bark distillate, fermented radish liquid, ethanol derived from plants such as sugar cane and corn, and 1,3-butylene glycol.

[0040] Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, cellulose-based powder, powder of grains (rice, wheat, corn, millet, etc.), powder of beans (soybean, adzuki bean, etc.), and the like.

[0041] Examples of ultraviolet absorbers include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, aloe extract, and the like.

[0042] Examples of antioxidants include butylhydroxyanisole, dibutylhydroxytoluene, propyl gallate, carotenoids such as astaxanthin, vitamin E and derivatives thereof (e.g., tocopherol acetate, tocopherol nicotinate), vitamin A and derivatives thereof (retinol palmitate, etc.), sodium sulfite, potassium sulfite, anhydrous sodium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium bisulfite, potassium bisulfite, ascorbic acid, sodium ascorbate, glycine, trimethylglycine, and the like.

[0043] Anti-inflammatory agents include allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, stearyl glycyrrhetinate, ε-aminocaproic acid, d-camphor, dl-camphor, zinc oxide, panthenol, pyridoxine hydrochloride, ibuprofen piconol, riboflavin and derivatives thereof.

[0044] The method for producing the skin external preparation of the present invention is not particularly limited, and can be produced by various methods, for example, using cannabinoid and sucrose fatty acid ester, and other components as necessary.For example, a method of mixing the raw material solution containing cannabinoid and the raw material solution containing sucrose fatty acid ester in random order can be mentioned.The raw material solution containing cannabinoid can contain various oily components.

[0045] The raw material solution containing sucrose fatty acid ester may contain a solvent, for example, the above-mentioned aqueous solvent (for example, water, a lower alcohol compound, a polyhydric alcohol compound, etc.). The polyhydric alcohol compound may be added after mixing the raw material solution containing the cannabinoid and the raw material solution containing the sucrose fatty acid ester. The ratio of the sucrose fatty acid ester to the solvent is not particularly limited, and for example, the amount of the solvent used may be 50 to 200 parts by mass, and preferably 80 to 150 parts by mass, per 100 parts by mass of the sucrose fatty acid ester.

[0046] For example, when mixing a raw material liquid containing a cannabinoid and a solvent and a raw material liquid containing a sucrose fatty acid ester and a solvent, the temperature during mixing is not particularly limited, and is, for example, 20 to 100°C, preferably 30 to 90°C, and more preferably 40 to 80°C. The mixing method is also not particularly limited, and for example, a known mixer can be widely used. The concentration can also be adjusted by further adding water or the like to the skin topical agent obtained as described above. EXAMPLES

[0047] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to the embodiments of these examples.

[0048] (Production Example 1) In a 1L flask equipped with a stirrer, a thermometer, a pressure reducing device, and a reflux device for dimethyl sulfoxide (DMSO), 400g of DMSO and 34.2g of sucrose were mixed and dissolved at 95°C. 2.4g of potassium carbonate and 15.0g of methyl stearate as a fatty acid ester were added thereto, and the mixture was reacted at 95°C for 3 hours under a reduced pressure of 2kPa. Subsequently, lactic acid was added to neutralize the mixture, and then DMSO was distilled off under reduced pressure. The obtained crude product was dissolved in 200g of methyl ethyl ketone, washed three times with 200g of 10% saturated saline, and the solvent was distilled off under reduced pressure to obtain sucrose fatty acid ester A. The average degree of esterification of sucrose fatty acid ester A was 1.01.

[0049] (Production Example 2) Fatty acid ester B was obtained in the same manner as in Production Example 1, except that the amount of methyl stearate used was changed to 15.5 g. The average esterification degree of sucrose fatty acid ester B was 1.04.

[0050] (Production Example 3) Fatty acid ester C was obtained in the same manner as in Production Example 1, except that the amount of methyl stearate used was changed to 16.1 g. The average esterification degree of sucrose fatty acid ester C was 1.08.

[0051] (Production Example 4) Fatty acid ester D was obtained in the same manner as in Production Example 1, except that 13.6 g of methyl palitate was used instead of methyl stearate. The average degree of esterification of sucrose fatty acid ester D was 1.01.

[0052] (Production Example 5) A fatty acid ester E was obtained in the same manner as in Production Example 1, except that 10.8 g of methyl laurate was used instead of methyl stearate. The average degree of esterification of sucrose fatty acid ester E was 1.01.

[0053] Example 1 A lotion was obtained by mixing 0.1 parts by weight of cannabidiol (CBD, manufactured by Sigma-Aldrich), 1 part by weight of sucrose fatty acid ester A, 0.2 parts by weight of squalane, 5 parts by weight of polyoxyethylene (5.5) cetyl alcohol, 0.02 parts by weight of tocopherol acetate, 0.5 parts by weight of dipotassium glycyrrhizinate, 0.08 parts by weight of isopropylmethylphenol, 5 parts by weight of 1,3-butylene glycol, 0.2 parts by weight of sodium citrate, 0.1 parts by weight of methylparaben, and 87.8 parts by weight of water. No aggregates or precipitates were found in the obtained lotion, and no aggregates or precipitates were found even after storage at 40°C for one month.

[0054] Example 2 A lotion was obtained in the same manner as in Example 1, except that 1 part by mass of sucrose fatty acid ester B was used instead of 1 part by mass of sucrose fatty acid ester A. No aggregates or precipitates were observed in the obtained lotion, and no aggregates or precipitates were observed even after storage at 40°C for 1 month.

[0055] Example 3 A lotion was obtained in the same manner as in Example 1, except that 1 part by mass of sucrose fatty acid ester C was used in place of 1 part by mass of sucrose fatty acid ester A. No aggregates or precipitates were observed in the obtained lotion, and no aggregates or precipitates were observed even after storage at 40°C for 1 month.

[0056] Example 4 A lotion was obtained in the same manner as in Example 1, except that 1 part by mass of sucrose fatty acid ester D was used instead of 1 part by mass of sucrose fatty acid ester A. No aggregates or precipitates were observed in the obtained lotion, and no aggregates or precipitates were observed even after storage at 40°C for 1 month.

[0057] Example 5 A lotion was obtained in the same manner as in Example 1, except that 1 part by mass of sucrose fatty acid ester E was used instead of 1 part by mass of sucrose fatty acid ester A. No aggregates or precipitates were observed in the obtained lotion, and no aggregates or precipitates were observed even after storage at 40°C for 1 month.

[0058] Example 6 A lotion was obtained in the same manner as in Example 1, except that the amount of sucrose fatty acid ester A used was changed to 0.5 parts by mass, and the amount of water used was changed to 88.3 parts by mass. No aggregates or precipitates were observed in the obtained lotion, and no aggregates or precipitates were observed even after storage at 40°C for 1 month.

[0059] Example 7 A lotion was obtained in the same manner as in Example 1, except that the amount of sucrose fatty acid ester A was changed to 2 parts by mass and the amount of water was changed to 86.8 parts by mass. No aggregates or precipitates were observed in the obtained lotion, and no aggregates or precipitates were observed even after storage at 40°C for 1 month.

[0060] Example 8 A lotion was obtained by mixing 0.1 parts by weight of cannabidiol (CBD, manufactured by Sigma-Aldrich), 1 part by weight of sucrose fatty acid ester A, 3 parts by weight of glyceryl caprylate, 3 parts by weight of polyglyceryl-10 laurate, 2 parts by weight of cetanol, 2 parts by weight of behenyl alcohol, 5 parts by weight of niacinamide, 0.1 parts by weight of dipotassium glycyrrhizinate, 1 part by weight of glycerin, 1 part by weight of 1,3-butylene glycol, 1 part by weight of pentanediol, 0.5 parts by weight of potassium hydroxide, and 80.3 parts by weight of water. No aggregates or precipitates were observed in the obtained lotion, and no aggregates or precipitates were observed even after storage at 40°C for one month.

[0061] Example 9 Cannabidiol (CBD, Sigma-Aldrich) 0.1 parts by weight, sucrose fatty acid ester A 1 part by weight, squalane 5 parts by weight, cyclopentane siloxane 1 part by weight, hexalan 3 parts by weight, hexyldecyl isostearate 1 part by weight, tri(caprylic acid / capric acid)glyceryl 1 part by weight, polyglyceryl-10 laurate 5 parts by weight, polyglyceryl-10 isostearate 5 parts by weight, ascorbyl dipalmitate 15 parts by weight, hydrogenated soybean lecithin 1.5 parts by weight, ascorbic acid phosphate magnesium salt 3 parts by weight, arbutin 3 parts by weight, potassium hydroxide 0.5 parts by weight, A milky lotion was obtained by mixing 3 parts by weight of lycerin, 2 parts by weight of 1,3-butylene glycol, 0.3 parts by weight of carboxymethylcellulose, 0.2 parts by weight of xanthan gum, 0.2 parts by weight of tremella fuciformis polysaccharide, 0.01 parts by weight of sodium hyaluronate, 0.3 parts by weight of tocopherol acetate, 0.09 parts by weight of tocopherol nicotinate, 0.1 parts by weight of glycyrrhizic acid, 0.1 parts by weight of dipotassium glycyrrhizinate, 0.1 parts by weight of isopropyl methylphenol, 1 part by weight of water-soluble collagen, 1 part by weight of hydrolyzed collagen, 0.1 parts by weight of acetyl hyaluronic acid, and 46.4 parts by weight of water. No aggregates or precipitates were found in the obtained lotion, and no aggregates or precipitates were found even after storage at 40°C for 1 month.

[0062] Example 10 A cream was obtained by mixing 0.1 parts by mass of cannabidiol (CBD, manufactured by Sigma-Aldrich), 1 part by mass of sucrose fatty acid ester A, 5 parts by mass of olive oil, 5 parts by mass of squalane, 5 parts by mass of jojoba oil, 1 part by mass of jojoba wax, 1 part by mass of behenyl alcohol, 1 part by mass of stearyl alcohol, 1 part by mass of candelilla wax, 0.5 parts by mass of hydrogenated lecithin derived from soybeans, 1 part by mass of rice fermented by lactic acid bacteria, 1 part by mass of carboxyvinyl polymer, 1 part by mass of sodium alginate, 2 parts by mass of glycerin, 1 part by mass of pentanediol, and 74.4 parts by mass of water. No aggregates or precipitates were found in the obtained lotion, and no aggregates or precipitates were found even after storage at 40°C for 1 month.

Claims

[Claim 1] Contains a cannabinoid and a sucrose fatty acid ester, The sucrose fatty acid ester has an average degree of esterification of 1.00 to 1.15.