Antiperspirant composition for scalp

Abstract

To provide an antiperspirant composition for scalp that suppresses sweat from scalp, and suppresses a scalp odor while suppressing influence on skin indigenous bacteria on scalp.SOLUTION: An antiperspirant composition for scalp contains (A) at least one selected from the group consisting of phenolic bactericidal component, quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) antiperspirant component.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an antiperspirant composition for the scalp. [Background technology]

[0002] Body odor is mainly caused by the metabolism of a mixture of sebum and sweat by resident skin bacteria, resulting in the production of fatty acids, etc. Therefore, in order to suppress armpit odor and foot odor, it has been known to use topical compositions containing bactericidal components that suppress the proliferation of resident skin bacteria, such as triclosan and benzalkonium chloride, or topical compositions containing antiperspirant components that suppress the generation of sweat, such as aluminum chloride.

[0003] In recent years, the number of people who complain of discomfort due to sweat and odor not only from the armpits and feet but also from the head is increasing. It is known that the resident skin bacteria on the scalp, unlike those on other parts of the skin, are mostly composed of Staphylococcus captis, a bacterium of the genus Staphylococcus, and it is believed that this difference in composition is one of the reasons why the odor of the scalp is different from the odor of the skin on other parts of the skin (Non-Patent Document 1). [Prior art documents] [Non-patent literature]

[0004] [Non-Patent Document 1] Research on Head Odor, Journal of Cosmetic Technology, 28(3):295-298, 1994 Summary of the Invention [Problem to be solved by the invention]

[0005] However, research and development of antiperspirant compositions that focus on the characteristics of the scalp has not yet progressed sufficiently.

[0006] The present inventors have conducted intensive studies in light of the current situation, and as a result, have focused on the following problem. Since skin resident bacteria maintain the ecological balance of the skin surface and exert barrier functions, etc., when an external composition containing a bactericidal component is used on the scalp, depending on the type of the bactericidal component, the ecological balance of the skin resident bacteria on the scalp may be disrupted, causing head odor or inhibiting barrier functions, etc., which may lead to skin diseases. In particular, when an external composition containing an antiperspirant component that suppresses sweat generation in addition to a bactericidal component is used on the scalp, depending on the type of each component, an additive bactericidal effect that is higher than the bactericidal effect when the bactericidal component is used alone may be generated on the skin resident bacteria on the scalp, which may significantly disrupt the ecological balance of the skin resident bacteria on the scalp.

[0007] Furthermore, when the topical composition is applied to the scalp, there are concerns that the topical composition may drip onto the face or other areas, causing discomfort, and may affect the hairstyle.

[0008] The present invention has been made in consideration of the above problems, and has an object to provide an antiperspirant composition for the scalp that can suppress sweat generation, reduce the effect on resident skin bacteria on the scalp, and suppress scalp odor.

[0009] Another object of the present invention is to provide an antiperspirant composition for the scalp that suppresses dripping from the head and has good usability. [Means for solving the problem]

[0010] The present inventors have conducted intensive research in view of the above problems, and have unexpectedly found that by using an antiperspirant composition for the scalp containing at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and an antiperspirant component, it is possible to suppress sweat generation, easily maintain the ecological balance of the resident skin bacteria on the scalp, and suppress scalp odor, which are remarkable effects. In addition, it has been found that the composition has the remarkable effects of suppressing dripping from the head and having good usability, and thus the present invention has been completed.

[0011] That is, the present invention relates to the following inventions: [1] An antiperspirant composition for scalp containing (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component. [2] The scalp antiperspirant composition according to [1], wherein the phenol-based bactericidal component is at least one selected from the group consisting of isopropylmethylphenol, triclosan, and trichlorocarbanilide. [3] The scalp antiperspirant composition according to [1] or [2], wherein the quaternary ammonium salt is at least one selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, and cetyltrimethylammonium bromide. [4] The antiperspirant composition for scalp according to any one of [1] to [3], wherein the component (B) is at least one selected from the group consisting of aluminum chlorohydrate, aluminum chloride, an aluminum zirconium complex salt, aluminum chlorohydrate allantoin, and zinc p-phenolsulfonate. [5] The antiperspirant composition for scalp according to any one of [1] to [4], further comprising (C) powder. [6] The antiperspirant composition for scalp according to any one of [1] to [5], further comprising (D) a cooling component. [7] The antiperspirant composition for scalp according to any one of [1] to [6], which is used for controlling resident skin bacteria on the scalp. [8] A method for controlling resident skin bacteria on the scalp using (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component. Effect of the Invention

[0012] According to the present invention, it is possible to provide an antiperspirant composition for the scalp that can suppress sweat production, easily maintain the balance of resident skin bacteria on the scalp, and suppress scalp odor.

[0013] Furthermore, according to the present invention, it is possible to provide an antiperspirant composition for the scalp that is easy to use by suppressing dripping from the head. [Brief description of the drawings]

[0014] [Figure 1] FIG. 1 shows the results of evaluating the metabolic inhibitory effect of bacteria, as described in the Examples below. [Diagram 2] FIG. 2 is a diagram showing the results of evaluating the metabolic inhibitory effect of bacteria, as described in the Examples below. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] Hereinafter, the embodiments of the present invention will be described in detail, however, the present invention is not limited to the following embodiments.

[0016] <Antiperspirant Composition for Scalp> The present invention relates to an antiperspirant composition for scalp containing (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component, and further contains, as necessary, (C) a powder, (D) a cooling component, or other components.

[0017] <Component (A)> The (A) component is a specific bactericidal component, and is at least one selected from the group consisting of phenolic bactericidal components, quaternary ammonium salts, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione. Examples of phenolic bactericidal components include isopropylmethylphenol, triclosan, and trichlorocarbanilide. Examples of quaternary ammonium salts include benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, and cetyltrimethylammonium bromide. Among these, from the viewpoint of further enhancing the effects of the present invention, isopropylmethylphenol, piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione are preferred. More preferred are isopropylmethylphenol, piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione. Even more preferred are isopropylmethylphenol, benzalkonium chloride, cetyltrimethylammonium bromide, and glycyrrhetinic acid. These may be used alone or in combination of two or more.From the viewpoint of further enhancing the effects of the present invention, preferred combinations include, for example, a combination containing at least isopropylmethylphenol and one or more selected from the group consisting of piroctone olamine, benzalkonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione, or a combination containing at least benzalkonium chloride and one or more selected from the group consisting of piroctone olamine, isopropylmethylphenol, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, glycyrrhetinic acid, and zinc pyrithione, and a combination containing at least isopropylmethylphenol and cetyltrimethylammonium bromide, isopropylmethylphenol, More preferred are isopropylmethylphenol and cetyltrimethylammonium bromide, isopropylmethylphenol and benzalkonium chloride, benzalkonium chloride and cetyltrimethylammonium bromide, benzalkonium chloride and glycyrrhetinic acid, benzalkonium chloride and cetylpyridinium chloride, still more preferred are isopropylmethylphenol and cetyltrimethylammonium bromide, isopropylmethylphenol and glycyrrhetinic acid, isopropylmethylphenol and benzalkonium chloride, benzalkonium chloride and cetyltrimethylammonium bromide, benzalkonium chloride and glycyrrhetinic acid, benzalkonium chloride and cetylpyridinium chloride, and still more preferred are isopropylmethylphenol and benzalkonium chloride.

[0018] The content of the (A) component is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.001 w / w% or more, preferably 0.005 w / w% or more, and more preferably 0.01 w / w% or more, based on the total amount of the composition. The content of the (A) component is not particularly limited, but is, for example, 0.2 w / w% or less, preferably 0.15 w / w% or less, and more preferably 0.1 w / w% or less, based on the total amount of the composition.

[0019] When the scalp antiperspirant composition containing the component (A) is an aerosol agent, the content of the component (A) exemplified above is the content relative to the total amount of the composition excluding the propellant.

[0020] <(B) component> The component (B) is an antiperspirant component that inhibits sweat generation by astringing or blocking sweat glands, and examples thereof include aluminum compounds, zirconium compounds, zinc compounds, aluminum and zirconium complex compounds, and alum. Examples of aluminum compounds include aluminum chloride, aluminum sulfate, aluminum potassium sulfate, aluminum ammonium sulfate, aluminum acetate, aluminum chlorohydrate, aluminum allantoin chlorohydrate, and aluminum bromohydrate. Examples of zirconium compounds include zirconium oxide and zirconium chlorohydrate. Examples of zinc compounds include zinc paraphenolsulfonate and zinc oxide. Examples of aluminum and zirconium complex compounds include aluminum zirconium complex salts. Among these, from the viewpoint of further enhancing the effects of the present invention, preferred are aluminum chlorohydrate, aluminum zirconium complex salts, zinc paraphenolsulfonate, and alum. More preferred are aluminum chlorohydrate, zinc paraphenolsulfonate, and alum. Even more preferred are aluminum chlorohydrate and zinc paraphenolsulfonate. These may be used alone or in combination of two or more.

[0021] The content of the (B) component is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.01 w / w% or more, preferably 0.05 w / w% or more, and more preferably 0.1 w / w% or more, based on the total amount of the composition. The content of the (B) antiperspirant component is not particularly limited, but is, for example, 30 w / w% or less, preferably 25 w / w% or less, and more preferably 15 w / w% or less, based on the total amount of the composition.

[0022] When the component (B) is an aluminum compound or a zirconium compound, its content is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.1 w / w% or more, preferably 0.5 w / w% or more, and more preferably 1 w / w% or more, based on the total amount of the composition. Also, when the component (B) is an aluminum compound or a zirconium compound, its content is not particularly limited, but is 30 w / w% or less, preferably 25 w / w% or less, and more preferably 15 w / w% or less.

[0023] When the (B) component is a zinc compound, its content is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention, it is, for example, 0.01 w / w% or more, preferably 0.05 w / w% or more, more preferably 0.1 w / w% or more, based on the total amount of the composition. When the (B) component is a zinc compound, its content is not particularly limited, but for example, 10 w / w% or less, preferably 5 w / w% or less, more preferably 3 w / w% or less, based on the total amount of the composition.

[0024] When the scalp antiperspirant composition containing the (B) component is an aerosol, its content is not particularly limited, but from the viewpoint of further enhancing the effect of the present invention, it is, for example, 0.01 w / w% or more, preferably 0.05 w / w% or more, more preferably 0.1 w / w% or more, based on the total amount of the composition excluding the propellant. Also, the content of the (B) component in the aerosol is not particularly limited, but is, for example, 5 w / w% or less, preferably 4 w / w% or less, more preferably 3 w / w% or less, based on the total amount of the composition excluding the propellant.

[0025] The ratio of the content of the (B) component to the content of the (A) component is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention, for example, the content of the (B) component is 0.1 to 30,000 parts by weight, preferably 0.3 to 5,000 parts by weight, and more preferably 1 to 1,500 parts by weight per 1 part by weight of the (A) component.

[0026] <(C) Powder> From the viewpoint of further improving the feeling of use of the scalp antiperspirant composition of the present invention, it is preferable to further include (C) powder. Examples of (C) powder include organic powder and inorganic powder. Examples of organic powder include corn starch, rice starch, tapioca starch, potato starch, wheat starch, siliconate-modified starch, sodium starch octenyl succinate, aluminum starch octenyl succinate, polyurethane, nylon powder, polystyrene resin, methylsiloxane network polymer, polymethylmethacrylate resin, melamine resin, phenolic resin, fluorine resin, cellulose, silicone resin, etc. Examples of polyurethane include (HDI / trimethylolhexyllactone) crosspolymer, etc. Examples of polymethylmethacrylate resin include methylmethacrylate crosspolymer, polymethylmethacrylate, etc. Examples of silicone resins include (dimethicone / vinyl dimethicone) crosspolymer, (diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane) crosspolymer, (vinyl dimethicone / methicone silsesquioxane) crosspolymer, etc. Examples of inorganic powders include sericite, mica, kaolin, red iron oxide, clay, bentonite, silica (silicic anhydride / hydrated silicon dioxide), talc, and the like whose surfaces are treated with silicone or the like. Among these, from the viewpoint of further enhancing the effects of the present invention and the feeling of use, preferred are corn starch, rice starch, tapioca starch, potato starch, wheat starch, siliconate-modified starch, starch sodium octenylsuccinate, starch aluminum octenylsuccinate, polyurethane, nylon powder, polystyrene resin, methylsiloxane network polymer, polymethylmethacrylate resin, cellulose, silica (silicic anhydride / hydrated silicon dioxide), talc, silicone surface-treated silica, silicone surface-treated talc, and silicone resin.More preferred are corn starch, sodium starch octenylsuccinate, aluminum starch octenylsuccinate, polyurethane, nylon powder, methylsiloxane network polymer, polymethylmethacrylate resin, silica (anhydrous silicic acid / hydrated silicon dioxide), talc, silicone surface-treated silica, silicone surface-treated talc, and silicone resin. More preferably, the corn starch, sodium starch octenyl succinate, aluminum starch octenyl succinate, (HDI / trimethylol hexyl lactone) crosspolymer, nylon powder, methylsiloxane network polymer, methyl methacrylate crosspolymer, polymethyl methacrylate, silica (anhydrous silicic acid / hydrated silicon dioxide), talc, (dimethicone / vinyl dimethicone) crosspolymer, (diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane) crosspolymer, (vinyl dimethicone / methicone silsesquioxane) crosspolymer, silicone surface-treated silica, silicone surface-treated talc are particularly preferred. These may be used alone or in combination of two or more.

[0027] (C) The shape of the powder is not particularly limited, but examples thereof include spherical, plate-like, granular, and needle-like shapes.

[0028] (C) Commercially available powder products include, for example, KSP-102, KSP-300, KMP-590, KMP-591, and KSG-15 (all manufactured by Shin-Etsu Chemical Co., Ltd.), SP-500 (manufactured by Toray Industries, Inc.), Fine Pearl (manufactured by Sumitomo Chemical Co., Ltd.), Techpolymer SB, Techpolymer MB (all registered trademarks manufactured by Sekisui Chemical Industry Co., Ltd.), Fine Powder SGP, Fine Powder MP (all manufactured by Soken Chemical Industries, Inc.), Tospearl 145, Tospearl 2000B (all registered trademarks manufactured by Toshiba Silicones, Inc.), BY29-129, Trefil (registered trademark manufactured by Dow Corning Toray Silicones, Inc.), Matsumoto Microsphere M (manufactured by Matsumoto Yushi Seiyaku Co., Ltd.), Japanese Pharmacopoeia Corn Starch ST-C (manufactured by Nippon Starch Chemical Co., Ltd.), Corn Starch (manufactured by Matsutani Chemical Industry Co., Ltd.), Dry Flow Examples of suitable talc beads include PC (manufactured by Akzo Nobel), silica beads SB-300, SA-SB-300, SA-TALC JA-13R, SA-TALC JA-46R, and SA-TALC JA-68R (all manufactured by Miyoshi Chemical Industries, Ltd.), Aerosil 200 (registered trademark, manufactured by Nippon Aerosil Co., Ltd.), Talc JA-46R, and Talc MMR (all manufactured by Asada Flour Milling Co., Ltd.), Ganz Pearl GM-0610, Ganz Pearl GMX-0810, and Ganz Pearl GPA-550 (all registered trademarks, manufactured by Aica Kogyo Co., Ltd.), PLASTIC POWDER D-400, PLASTIC POWDER D-400HP, and PLASTIC POWDER D-800 (all manufactured by Toshoku Pigment Co., Ltd.).

[0029] The content of the powder (C) is not particularly limited, but from the viewpoint of further enhancing the effects and usability of the present invention, it is, for example, 0.1 w / w% or more, preferably 0.3 w / w% or more, and more preferably 0.5 w / w% or more, based on the total amount of the composition. The content of the powder (C) is not particularly limited, but is, for example, 30 w / w% or less, preferably 20 w / w% or less, and more preferably 10 w / w% or less, based on the total amount of the composition.

[0030] The content of the powder (C) is not particularly limited, but is selected according to the dosage form from the viewpoint of further enhancing the effect and usability of the present invention. In the case of an aerosol, it is, for example, 1 w / w% or more, preferably 3 w / w% or more, more preferably 5 w / w% or more, based on the total amount of the composition excluding the propellant. The content of the powder (C) is not particularly limited, but is, for example, 30 w / w% or less, preferably 25 w / w% or less, more preferably 20 w / w% or less, based on the total amount of the composition excluding the propellant.

[0031] The content of (C) powder is not particularly limited, but in the case of liquids such as roll-on types and mist types, emulsions, gels, and creams, it is, for example, 0.1 w / w% or more, preferably 0.3 w / w% or more, and more preferably 0.5 w / w% or more, based on the total amount of the composition. The content of (C) powder is not particularly limited, but is, for example, 20 w / w% or less, preferably 15 w / w% or less, and more preferably 10 w / w% or less, based on the total amount of the composition.

[0032] The ratio of the content of the (C) component to the content of the (A) component is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention and the feeling of use, for example, the content of the (C) component is 1 to 30,000 parts by weight, preferably 2 to 5,000 parts by weight, and more preferably 5 to 2,000 parts by weight per 1 part by weight of the (A) component.

[0033] The ratio of the content of the (C) component to the content of the (B) component is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention and the feeling of use, for example, the content of the (C) component is 0.003 to 3000 parts by weight, preferably 0.01 to 500 parts by weight, and more preferably 0.030 to 200 parts by weight per part by weight of the (B) component.

[0034] The average primary particle size of the powder (C) is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention and the feeling of use, it is, for example, 0.1 μm or more, preferably 1 μm or more, and more preferably 5 μm or more. The average primary particle size of the powder (C) is not particularly limited, but is, for example, 30 μm or less, preferably 20 μm or less, and more preferably 15 μm or less. The average primary particle size is measured by a laser diffraction scattering method.

[0035] <(D) Cooling ingredient> From the viewpoint of further improving the feeling of use of the scalp antiperspirant composition of the present invention, it is preferable to further contain (D) a refreshing component. Examples of (D) refreshing components include essential oils such as l-menthol, dl-menthol, l-menthyl glyceryl ether, l-menthyl lactate, menthyl salicylate, menthyl 3-hydroxybutyrate, menthoxypropanediol, dl-camphor, chlorobutanol, borneol, geraniol, cineol, limonene, eugenol, eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine. Among them, from the viewpoint of further improving the effect and feeling of use of the present invention, l-menthol, l-menthyl glyceryl ether, l-menthyl lactate, eucalyptus oil, peppermint oil, and chlorobutanol are preferable. More preferred are l-menthol, l-menthyl glyceryl ether, eucalyptus oil, and peppermint oil. These may be used alone or in combination of two or more.

[0036] The content of the (D) component is not particularly limited, but from the viewpoint of further enhancing the effects and usability of the present invention, it is, for example, 0.01 w / w% or more, preferably 0.05 w / w% or more, more preferably 0.1 w / w% or more, based on the total amount of the composition. The content of the (D) component is not particularly limited, but is, for example, 5 w / w% or less, preferably 3 w / w% or less, more preferably 1 w / w% or less, based on the total amount of the composition.

[0037] When the scalp antiperspirant composition containing the component (D) is an aerosol preparation, the content of the component (D) exemplified above is the content relative to the total amount of the composition excluding the propellant.

[0038] The ratio of the content of the (D) component to the content of the (A) component is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention and the feeling of use, for example, the content of the (D) component is 0.05 to 5000 parts by weight, preferably 0.3 to 600 parts by weight, and more preferably 1 to 100 parts by weight per 1 part by weight of the (A) component.

[0039] The ratio of the content of the (D) component to the content of the (B) component is not particularly limited, but from the viewpoint of further enhancing the effects of the present invention and the feeling of use, for example, the content of the (D) component is 0.0003 to 500 parts by weight, preferably 0.002 to 60 parts by weight, and more preferably 0.006 to 10 parts by weight per 1 part by weight of the (B) component.

[0040] <Other ingredients> The scalp antiperspirant composition of the present invention may contain components (other components) other than the above components (A) to (D) within the scope of not impairing the effects of the present invention. For example, a base or carrier, a surfactant, an oil, a thickener, a preservative, an antioxidant, a preservative, a chelating agent, a pH adjuster, a stabilizer, a solubilizer, a buffer, a dispersant, a colorant, a moisturizing component, a conditioning agent, a blood circulation promoter, an ultraviolet absorbing component, an ultraviolet scattering component, an anti-inflammatory agent, vitamins, an organic acid, a peptide or a derivative thereof, an amino acid or a derivative thereof, a cleansing component, a keratin softening component, a cell activating component, an anti-aging component, a scalp and hair care component, an anti-glycation component, etc. may be blended. The other components may be used alone or in combination of two or more.

[0041] <Base or Carrier> Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, gelling hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin; methyl polysiloxane, crosslinked methyl polysiloxane, highly polymerized methyl polysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone / alkyl chain co-modified polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, and a Examples of suitable bases include silicone oils such as acrylic silicone, phenyl-modified silicone, and silicone resin; polyethylene glycol; dioxane; esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra 2-ethylhexanoate, and tri(caprylic / capric acid)glyceryl; lower alcohols such as ethanol and isopropanol; glycol ethers such as diethylene glycol monomethyl ether and diethylene glycol monoethyl ether; polyhydric alcohols such as polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, and isoprene glycol; and aqueous bases such as water.

[0042] <Surfactant> Examples of the surfactant include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexyl acid, and diglycerol sorbitan tetra-2-ethylhexyl acid; glycerin fatty acid esters such as lipophilic glyceryl monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40); Hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), and polyoxyethylene hydrogenated castor oil 80 (HCO-80); polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), polyoxyethylene (80) sorbitan monolaurate, polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), polyoxyethylene (20) sorbitan isostearate Polyoxyethylene sorbitan fatty acid esters such as diethylene (20) sorbitan; polyoxyethylene fatty acid glyceryls such as polyoxyethylene monococoate glyceryl; glycerin alkyl ethers; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene cetyl ether; polyoxyethylene polyoxypropylene alkyl ethers such as polyoxyethylene polyoxypropylene decyl tetradecyl ether; nonionic surfactants such as polyoxyethylene lauryl alcohol ether; amines such as stearylamine and oleylamine; polyether modified silicones such as PEG-11 methyl ether dimethicone, PEG-10 dimethicone, PEG / PPG-19 / 19 dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone; polyether alkyl co-modified silicones such as lauryl PEG-9 polydimethylsiloxyethyl dimethicone and cetyl dimethicone copolyol; polyglycerin modified silicones; polyglycerin alkyl co-modified silicones; silicone surfactants such as crosslinked silicones;Laurates, palmitates, cocoyl glutamates, coconut oil methyl alanine salts, acyl methyl taurates, higher alkyl sulfates such as sodium lauryl sulfate; alkyl ether sulfates such as sodium POE-lauryl sulfate; N-acyl sarcosinates such as sodium lauroyl sarcosinate; POE-stearyl ether phosphate, potassium cetyl phosphate, cetyl phosphate; sulfosuccinates such as sodium di-2-ethylhexyl sulfosuccinate; alkyl benzene sulfonates; higher fatty acid ester sulfates; monosodium N-lauroyl glutamate, N-stearyl Examples of such surfactants include acyl glutamates such as disodium oyl glutamate and monosodium N-myristoyl-L-glutamate; anionic surfactants such as POE-alkyl ether carboxylic acids, POE-alkyl allyl ether carboxylates, α-olefin sulfonates, and higher fatty acid ester sulfonates; amphoteric surfactants such as lauryl diaminoethyl glycine salts, coconut oil fatty acid betaine salts, carbobetaine, sulfobetaine, imidazolinium betaine, and amidobetaine; and naturally derived surfactants such as lecithin, hydrogenated lecithin, saponin, sodium surfactin, and bile acid.

[0043] <Oil content> Examples of oils include natural animal and vegetable oils and fats, waxes, hydrocarbon oils, ester oils, silicone oils, higher alcohols, and higher fatty acids.

[0044] <Natural animal and vegetable oils> Examples of natural animal and vegetable oils and fats include avocado oil, linseed oil, almond oil, olive oil, cacao oil, wheat germ oil, sesame oil, rice germ oil, rice bran oil, safflower oil, soybean oil, evening primrose oil, camellia oil, corn oil, rapeseed oil, horse fat, persic oil, palm oil, palm kernel oil, castor oil, sunflower oil, lard, grape oil, jojoba oil, macadamia nut oil, kukui nut oil, hazelnut oil, cottonseed oil, Japan wax, coconut oil, hardened coconut oil, peanut oil, lanolin, egg yolk oil, rosehip oil, and shea butter.

[0045] <Waxes> Examples of waxes include jojoba oil, miu wax, candelilla wax, rice bran wax, cotton wax, carnauba wax, and lanolin.

[0046] <Hydrocarbon oil> Examples of the hydrocarbon oil that can be used include paraffinic hydrocarbons and olefinic hydrocarbons, such as squalane, squalene, ceresin, paraffin, pristane, microcrystalline wax, liquid paraffin, liquid isoparaffin, petrolatum, polybutene, polyethylene powder, gelled hydrocarbons, ozokerite, α-olefin oligomer, light liquid paraffin, and light iso liquid paraffin.

[0047] <Ester oil> Examples of the ester oil include synthetic esters and esters of higher alcohols and higher fatty acids, such as diisopropyl adipate, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, isostearyl isostearate, trimethylolpropane triisostearate, isononyl isononanoate, isotridecyl isononanoate, cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, ethyl oleate, cetyl octanoate, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, 2-ethylhexyl succinate, Isocetyl stearate, butyl stearate, diethyl sebacate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, tetradecyl lactate, isopropyl myristate, octyldodecyl myristate, cetyl myristate, myristyl myristate, octyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, isopropyl palmitate, cholesteryl 12-hydroxystearate, phytosteryl oleate, diisostearyl malate, paramethoxycinnamate, pentaerythritol tetrarosinate, bisethoxydiglycol cyclohexane-1,4-dicarboxylate, 2-ethylhexyl succinate, diethoxyethyl succinate, triethyl citrate, decaglyceryl (eicosandioic acid / tetradecanedioic acid).

[0048] <Silicone oil> Examples of silicone oils include dimethylpolysiloxane, highly polymerized methylpolysiloxane, phenyl-modified silicones such as methylphenylpolysiloxane, methylhydrogenpolysiloxane, cyclic silicones such as octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, and decamethylcyclohexasiloxane, crosslinked methylpolysiloxane, methylhydrogenpolysiloxane, methyltrimethicone, dimethiconol, and dimethiconol crosspolymer, higher alkoxy-modified silicones such as stearoxysilicone, alkyl-modified silicones such as caprylyl methicone, and higher fatty acid ester-modified silicones.

[0049] <Higher alcohol> Examples of higher alcohols include higher alcohols having 12 to 22 carbon atoms and sterols. Among them, examples include linear saturated alcohols such as lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, and behenyl alcohol; unsaturated alcohols such as oleyl alcohol and selachyl alcohol; or branched alcohols such as hexyldecanol, isostearyl alcohol, octyldodecanol, decyltetradecanol, lanolin alcohol, and isostearyl glyceryl ether, as well as phytosterol and cholesterol. Among them, it is preferable to use one or a combination of two or more selected from cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, oleyl alcohol, isostearyl alcohol, octyldodecanol, lanolin alcohol, isostearyl glyceryl ether, phytosterol, and cholesterol.

[0050] <Higher fatty acids> As the higher fatty acid, for example, a saturated or unsaturated straight-chain or branched-chain fatty acid having 12 to 22 carbon atoms can be used, and examples thereof include straight-chain saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, margaric acid, arachidonic acid, and behenic acid; unsaturated fatty acids such as oleic acid, linoleic acid, linolenic acid, arachidonic acid, palmitoleic acid, eicosapentaenoic acid, paccenic acid, and docosahexaenoic acid; or branched fatty acids such as isostearic acid and lanolin fatty acid, or 12-hydroxystearic acid. Among them, it is preferable to use one or more of lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, isostearic acid, and lanolin fatty acid in combination.

[0051] <Thickener> Examples of thickeners include guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydrophobized hydroxypropylmethylcellulose, pectin, pullulan, agar, sodium alginate, propylene glycol alginate, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylate / alkyl methacrylate copolymer, polyethylene glycol, (hydroxyethyl acrylate / Na acryloyldimethyltaurate) copolymer, (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer, and the like.

[0052] <Antioxidants> Examples of the antioxidant include dibutylhydroxytoluene (BHT), butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine ​​hydrochloride, tocopherol, and tocopherol acetate.

[0053] <Preservatives or antiseptics> Examples of preservatives or antiseptics include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, butyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, methyl p-hydroxybenzoate, phenoxyethanol, sorbic acid, chlorobutanol, benzyl alcohol, phenethyl alcohol, caprylic hydroxamic acid, methylisothiazolinone, propiolyl butylcarbamate iodide, and the like.

[0054] <Chelating agent> Examples of chelating agents include EDTA disodium salt, EDTA calcium disodium salt, polyphosphoric acid, metaphosphoric acid, and the like.

[0055] <pH adjuster> Examples of pH adjusters include inorganic acids (such as hydrochloric acid, sulfuric acid), organic acids (such as lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate), inorganic bases (such as potassium hydroxide, sodium hydroxide), organic bases (such as triethanolamine, diisopropanolamine, triisopropanolamine), and the like.

[0056] <Stabilizer> Examples of stabilizers include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, and the like.

[0057] <Solubilizing agent> Examples of solubilizing agents include polyhydric alcohols such as polyethylene glycol and propylene glycol, sugar alcohols such as D-mannitol, benzyl benzoate, ethanol, isopropanol, trisaminomethane, cholesterol, triethanolamine, sodium carbonate, sodium citrate, and the like.

[0058] <Buffer> Examples of the buffering agent include buffer solutions such as phosphate, acetate, carbonate, and citrate.

[0059] <Dispersant> Dispersants include, for example, sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymers, organic acids, and the like.

[0060] <Coloring agent> Examples of colorants include inorganic pigments and natural dyes.

[0061] <Moisturizing ingredients> Examples of moisturizing ingredients include polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, and diglycerin; polyhydric alcohol derivatives such as PEG / PPG / polybutylene glycol-8 / 6 / 3 glycerin, PPG-17 buteth-17, and PPG-24 glycereth-24; sugars such as glycosyl trehalose, trehalose, sorbitol, xylitol, oligosaccharides, and glyceryl glucoside; hyaluronic acids (hyaluronic acid derivatives such as sodium hyaluronate, low molecular weight hyaluronic acid, zinc hyaluronate, acetylated hyaluronic acid, and cationized hyaluronic acid), heparinoids, Examples of suitable organic compounds include polymeric compounds such as sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan; amino acids and derivatives thereof such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; lipids such as ceramide, glucosylceramide, cholesterol, phytosterol, and cholesterol-derived phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, green tea extract, perilla extract, sage extract, seaweed extract, rose hip extract, peony extract, mugwort extract, aloe extract, Scutellaria root extract, and pueraria root extract.

[0062] <Conditioning agent> Examples of conditioning agents include cationized cellulose, cationized starch, cationized fenugreek gum, cationized guar gum, cationized tara gum, cationized locust bean gum, cationized xanthan gum, diallyl quaternary ammonium salt / acrylamide copolymer, polyquaternium, vinylimidazolium trichloride / vinylpyrrolidone copolymer, hydroxyethyl cellulose / dimethyl diallyl ammonium chloride copolymer, vinylpyrrolidone / quaternary dimethylaminoethyl methacrylate copolymer, polyvinylpyrrolidone / alkylaminoacrylate copolymer, polyvinylpyrrolidone / alkylaminoacrylate / vinylcaprolactam copolymer, vinylpyrrolidone / methacrylamidopropyl trimethylammonium chloride copolymer, alkylacrylamide / acrylate / alkylaminoalkylacrylamide / polyethylene glycol methacrylate copolymer, and adipic acid / dimethylaminohydroxypropyl ethylenetriamine copolymer.

[0063] <Blood circulation promoter> Examples of blood circulation promoters include acetylcholine, ichthammol, caffeine, capsaicin, cantharides tincture, gamma oryzanol, safflower tincture, zingerone, cepharanthine, Swertia japonica extract, tannic acid, capsicum tincture, tolazoline, glucosyl hesperidin, hesperidin, dl-α-tocopherol acetate, tocopherol nicotinate, nicotinic acid benzyl ester, ginseng extract, carrot extract, clove extract, tangerine peel extract, angelica extract, ginger extract, rehmannia extract, angelica extract, peony extract, carrot extract, Hypericum perforatum extract, and cinnamon bark extract.

[0064] <UV absorbing ingredients> Examples of ultraviolet absorbing components include octyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, dimethoxybenzylidene dioxoimidazolidine propionate octyl, 2-ethylhexyl paramethoxycinnamate, t-butyl methoxydibenzoylmethane, phenylbenzimidazole sulfonic acid, octyl methoxycinnamate, ethylhexyl methoxycinnamate, octocrylene, and dimethicodethyl benzalmalonate.

[0065] <Ultraviolet scattering component> Examples of ultraviolet scattering components include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zinc oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and anhydrous silicic acid; these inorganic compounds are coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica, and talc; or are composited with resin powders such as polyamide, polyethylene, polyester, polystyrene, and nylon; and further, are treated with silicone oil, aluminum salts of fatty acids, or the like.

[0066] <Anti-inflammatory agents> The anti-inflammatory agent may be, for example, a steroidal anti-inflammatory agent or a non-steroidal anti-inflammatory agent, including, but not limited to, allantoin, glycyrrhizic acid or a salt thereof, steroids such as prodnisolone valerate acetate or hydrocortisone, ufenamate, bufexamac, ibuprofen piconol, glycol salicylate, and tranexamic acid. Further examples include indomethacin, diclofenac, piroxicam, epsilon-aminocaproic acid, berberine, lysozyme, azulene, and pharma- ceutically acceptable salts thereof, and plant-derived components (e.g., components derived from extracts of comfrey, coptis jasmine, Houttuynia cordata, chlorella, echinacea leaf, saxifrage, scutellaria, artemisia capillaris, perilla, calamus root, sage, hawthorn, clove, neem leaf, betel berry, peach leaf, cherry leaf, artichoke, seaweed, tea, etc.). Preferably, it is a combination with one or more selected from allantoin, tranexamic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, epsilon-aminocaproic acid, azulene and its derivatives, and more preferably, it is a combination with one or more selected from allantoin, tranexamic acid, dipotassium glycyrrhizinate and epsilon-aminocaproic acid.

[0067] <Vitamins> Examples of vitamins include vitamin E such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; vitamin B2 such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, and riboflavin tetranicotinate; nicotinic acid, nicotinic acid amide, dl-α-tocopherol nicotinate, and nicotinic acid amide. Nicotinic acids such as benzyl cotinate, methyl nicotinate, β-butoxyethyl nicotinate, and 1-(4-methylphenyl)ethyl nicotinate; ascorbigen-A, ascorbyl stearate, ascorbyl palmitate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate, trisodium ascorbyl palmitate phosphate, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, Vitamin C such as ascorbic acid glucoside, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, glyceryl ascorbic acid, bisglyceryl ascorbic acid, and alkyl glyceryl ascorbic acid; Vitamin D such as methyl hesperidin, ergocalciferol, and cholecalciferol; Vitamin K such as phylloquinone and falnoquinone; gamma-oryzanol; dibenzoyl thiamine; dibenzoyl thiamine hydrochloride; thiamine and its salts (e.g., dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine nihydroxide, thiamine nitrate ... Vitamin B1 such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride; Vitamin B12 such as cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid; retinol derivatives such as retinol, retinol acetate, retinol palmitate, retinol propionate, and retinol linoleate; Vitamin A such as retinal, retinoic acid, and tocopheryl retinoate;Provitamins A such as carotene, lycopene, zeaxanthin, cryptoxanthin, and echinenone; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesine, D-pantethine, coenzyme A, and pantothenyl ethyl ether; biotins such as biotin and bioticin; vitamin-like factors such as carnitine, ferulic acid, α-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, glucosyl hesperidin, and ubiquinone;

[0068] <Organic acid> Examples of organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid, lactic acid, pantothenic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, glutamic acid, azelaic acid, and salts thereof. Examples of salts include salts of mineral acids such as sulfuric acid, hydrochloric acid, and phosphoric acid, salts of organic acids such as maleic acid and methanesulfonic acid, salts of alkali metals such as sodium and potassium, alkaline earth metal salts, ammonium salts, salts of basic amino acids, and salts of amines such as triethanolamine. Of these, a combination with one or more selected from gluconic acid, citric acid, glutamic acid, succinic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and salts thereof is preferred, and a combination with one or more selected from gluconic acid, citric acid, glutamic acid, succinic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, lactic acid, and salts thereof is more preferred.

[0069] <Peptide or its derivative> Examples of peptides or derivatives thereof include keratin hydrolyzed peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, succinylated atelocollagen, gelatin, elastin, elastin hydrolyzed peptides, collagen hydrolyzed peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed peptides, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolyzed peptides, and acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

[0070] <Amino acid or its derivative> Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, and sodium N-stearoyl-L-glutamate.

[0071] <Cleaning ingredients> Examples of cleaning components include alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate, or potassium stearate, soaps such as alkanolamide salts or amino acid salts, amino acid surfactants such as sodium cocoyl glutamate and sodium cocoyl methyl taurate, ether sulfate salts such as sodium laureth sulfate, ether carboxylate salts such as sodium lauryl ether acetate, sulfosuccinate salts such as sodium alkys sulfosuccinate, fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide and coconut oil fatty acid diethanolamide, monoalkyl phosphate salts such as sodium lauryl phosphate and sodium polyoxyethylene lauryl ether phosphate, betaine-type amphoteric surfactants such as coconut oil fatty acid amidopropyl dimethylaminoacetate betaine, lauryl dimethylaminoacetate betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryl hydroxysulfobetaine, and lauroyl amidoethyl hydroxyethyl carboxymethyl betaine hydroxypropyl phosphate sodium, and amino acid amphoteric surfactants such as sodium lauryl aminopropionate.

[0072] <keratin softening ingredient> Examples of keratin softening ingredients include lanolin, urea, phytic acid, lactic acid, lactate salts, glycolic acid, salicylic acid, malic acid, citric acid, fruit acid, phytic acid, urea, sulfur, etc. Among these, lactic acid, sodium lactate, glycolic acid, salicylic acid, phytic acid, and citric acid are preferred.

[0073] <Cell activation components> Examples of cell activation components include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acid pyrroloquinoline quinones; α-hydroxy acids such as gluconic acid, phytic acid, glycolic acid, and lactic acid; tannin, persimmon tannin, flavonoids, saponin, allantoin, photosensitizer No. 301, panthenol, and components derived from plants (e.g., soybean sprouts, bilberry leaves, etc.).

[0074] <Anti-aging ingredients> Examples of anti-aging ingredients include hydrolyzed soy protein, retinoids (retinol, retinoic acid, retinal, etc.), pangamic acid, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, peptides (caprooyl tetrapeptide-3, oligopeptide-24, etc.), etc. Among these, hydrolyzed soy protein, retinol, retinol acetate, retinol palmitate, caprooyl tetrapeptide-3, and oligopeptide-24 are preferred.

[0075] <Anti-glycation ingredient> Examples of anti-glycation ingredients include plant extracts such as Budreja axillaris leaf extract, plum fruit extract, and edelweiss extract, evening primrose oil, Amla fruit, fruit juice or extracts thereof, L-arginine, L-lysine, hydrolyzed casein, hydrolyzable tannin, and carnosine.

[0076] <Scalp and hair care ingredients> Examples of scalp and hair care ingredients include minoxidil, finasteride, carpronium chloride, pyridine N-oxide, nicotinic acid derivatives (nicotinamide, benzyl nicotinate, tocopherol nicotinate, etc.), γ-oryzanol, capsicum tincture, cepharanthine, vitamin B2, vitamin B6, vitamin B12, pantothenic acid, tocopherol acetate, tocopherol, panthenol, biotin, hydrolyzed soy protein, soy extract, coix seed, ginkgo extract, carrot extract, Swertia japonica extract, aloe extract, Angelica acutiloba extract, Malva sylvestris extract, caffeine, chamomile extract, seaweed extract, fucoidan, gentiana extract, Enmeiso extract, ginseng tincture, Kashu tincture, arnica tincture, and female hormones (estradiol, etc.).

[0077] <ph> The pH of the scalp antiperspirant composition of the present invention is not particularly limited as long as the effects of the present invention can be achieved, but is, for example, pH 3 or higher, preferably pH 3.5 or higher, more preferably pH 4 or higher, and pH 9 or lower, preferably pH 8 or lower, and even more preferably pH 7.5 or lower.

[0078] <Dosage form> The scalp antiperspirant composition of the present invention is not particularly limited as long as it is in a known form, and can be formulated by a known method in the form of, for example, a liquid, a suspension, an emulsion, a cream, an ointment, a gel, a liniment, a lotion, an aerosol, a powder, a sheet in which a sheet such as a nonwoven fabric is impregnated with the scalp antiperspirant composition, a mist, etc. Among them, a liquid, a suspension, an emulsion, a cream, a milky lotion, an ointment, a gel, a lotion, a sheet, an aerosol, and a mist are preferred, a liquid, a suspension, an emulsion, a gel, a lotion, a sheet, an aerosol, and a mist are more preferred, and a liquid, a suspension, a lotion, a sheet, an aerosol, and a mist are even more preferred.

[0079] <Aerosol agent> The aerosol agent is an aerosol type spray container filled with the scalp antiperspirant composition and a propellant. Examples of the propellant used in the aerosol agent include fluorocarbon gases such as fluorocarbon 11, fluorocarbon 12, fluorocarbon 21, fluorocarbon 113, fluorocarbon 114, and fluorocarbon 134a, liquefied petroleum gases (LPG) such as propane, isobutane, and normal butane, and liquefied gases such as dimethyl ether (DME). In addition to these, carbon dioxide gas, nitrogen gas, oxygen gas, and the like may be used.

[0080] The ratio of the scalp antiperspirant composition to the propellant (weight ratio of scalp antiperspirant composition / propellant) is not particularly limited, but is usually 1:9 to 9:1, and preferably 2:8 to 8:2.

[0081] <Sheet material> The sheet agent is obtained by impregnating a sheet substrate with the antiperspirant composition for scalp of the present invention. The sheet substrate is not particularly limited as long as it can be impregnated with the antiperspirant composition for scalp, and woven fabric, nonwoven fabric, etc. can be used as desired. The fibers constituting the woven fabric and nonwoven fabric are not particularly limited, and can be selected from, for example, synthetic fibers, natural fibers, or fibers made by mixing and combining these. Specific examples of the fibers include, but are not limited to, rayon fibers, cotton, pulp, cellulose, Tencel, Lyocell, chitin, chitosan, collagen, alginic acid, and other fiber materials. In addition, any thermoplastic binder can be included, and examples of the thermoplastic binder include, but are not limited to, thermoplastic binders composed of various resins such as polyolefins such as polyethylene and polypropylene; polyesters such as polyethylene terephthalate, polytrimethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, and polybutylene naphthalate; polyamides such as nylon; and polyacrylonitrile. The thermoplastic binder contained in the nonwoven fabric may contain one type of the above-mentioned thermoplastic binder alone or two or more types of the above-mentioned thermoplastic binders in any combination. The basis weight of the sheet substrate is not particularly limited, and is, for example, 10 to 100 g / m 2 , preferably 20 to 80 g / m 2 , more preferably 30 to 70 g / m 2 , and more preferably 30 to 60 g / m 2 It is. The sheet substrate may be a sheet substrate having a three-dimensional pattern represented by an uneven shape on at least one of the front and back surfaces, in which any shape is regular or irregular, or may be a sheet substrate having no such three-dimensional pattern. The uneven shape can be processed by any method, such as mesh processing, embossing, dot processing, or a combination of these processing methods, and a method including mesh processing (for example, a method of performing only mesh processing, a method of combining mesh processing and embossing, a method of combining mesh processing and dot processing, etc.) is preferred. The amount of the scalp antiperspirant composition impregnated into the sheet substrate is not particularly limited, and can usually be in the range of 0.5 to 20 times the weight of the sheet substrate, and preferably 1 to 10 times. A scalp sheet impregnated with the scalp antiperspirant composition of the present invention is preferable in that, by wiping the head with the scalp sheet, it is possible to suppress the generation of sweat from the scalp, suppress the effect on the scalp's resident skin bacteria, and suppress the odor of the scalp, and in addition, it is possible to wipe away sweat, sebum, etc., and to easily refresh the head. In particular, the scalp sheet impregnated with the scalp antiperspirant composition of the present invention is more preferably used, for example, when wiping the area around the forehead where sweat is likely to accumulate and the area around the back of the head where odor is likely to accumulate, and when wiping the entire head of a person with short hair such as a buzz cut or short hair.

[0082] <Container> The scalp antiperspirant composition of the present invention can be stored in a container of a shape and material appropriately selected according to the purpose and application of use, and used. Specific examples of the container include spray type, bottle type, tube type, jar type, dropper type, dispenser type, stick type, pouch bag, and cheer pack. The scalp antiperspirant composition of the present invention can be used by changing the head part of each container to a sponge-like head, a drop-type head, a pen-type head, a roll-on type head, a spatula-like head, a brush-like head, a pin-holder-type head, etc., from the viewpoint of ease of application to the scalp. In addition, examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal (aluminum, etc.). In addition, these materials can be used as container materials by performing various coating treatments, combining these materials by, for example, mixing them, or laminating them, taking into consideration strength, flexibility, weather resistance, or stability of the components. Examples of coating materials include epoxy resin, polyamideimide, etc. Among them, it is preferable to use polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, and metal (aluminum, etc.).

[0083] The sheet agent is preferably provided in a highly airtight container. The sheet agent may be individually packaged as a one-time use type, or may be packaged in a package of wipe sheet agents for multiple uses so that the wipe sheet agent can be used multiple times. When packaged as a multiple use type, the container is preferably structured so that the lid can be opened and closed each time it is used, and the opening can be closed when not in use. Here, the lid member that makes the opening openable and closable may be a lid member integrally formed with the container, a lid member connected to the container, or a lid member that can be removed from the container. The lid member that can be removed from the container may be, for example, a seal-like member with an adhesive layer that can seal the opening with the adhesive layer each time it is used. In addition, when a seal-like member is used, the adhesive layer does not necessarily have to be present on the surface of the lid member side, and may be present on the surface of the container side (for example, around the opening). The materials for the container and the lid member may be any material well known in the art that has excellent airtightness, including, but not limited to, polyolefin resins such as polyethylene and polypropylene, metals such as aluminum, and laminated films laminated with aluminum foil. From the viewpoint of ease of carrying when going out and easy handling, it is preferable that the container is packaged in a bag-like container made of a laminated film laminated with aluminum foil, with a sealed lid member that allows the opening to be opened and closed each time it is used.

[0084] <Usage> Specific applications of the composition for quasi-drugs or cosmetics include, for example, skin lotions, milky lotions, gels, creams, beauty essences, cosmetics with sunscreen functions, basic scalp cosmetics such as mists, sprays, and wipes; and cleansing cosmetics such as dry shampoos, shampoos, rinses, and treatments.

[0085] <Viscosity> The viscosity (25°C) of the scalp antiperspirant composition of the present invention is not particularly limited as long as the effects of the present invention can be achieved. For example, in the case of a solution, a suspension, a lotion, an aerosol, a mist, or a sheet, the viscosity is preferably in the range of 0.01 to 50,000 mPa·s. Furthermore, the range of 0.1 to 5,000 mPa·s is more preferable, and the range of 1 to 1,000 mPa·s is more preferable. In the case of an emulsion, a gel, or a cream, the viscosity is preferably in the range of 10 to 1,000,000 mPa·s. Furthermore, the range of 1,000 to 500,000 mPa·s is more preferable, and the range of 10,000 to 100,000 mPa·s is more preferable. The viscosity (25°C: mPa·s) is a viscosity measured using a single cylindrical rotational viscometer (Brookfield viscometer) in accordance with the viscosity measurement method described in the general test method of the 17th revised Japanese Pharmacopoeia.

[0086] <Production method> The method for producing the scalp antiperspirant composition of the present invention is not particularly limited, and it can be produced by dissolving, mixing, or dispersing the components (A) to (D) and other components using a conventional method suitable for the dosage form and shape.

[0087] <Application> The present invention is an antiperspirant composition for the scalp that is useful for the scalp, and can be used for controlling resident skin bacteria on the scalp or for suppressing odor on the scalp. The agent used for controlling resident skin bacteria on the scalp is beneficial in that it can suppress the imbalance of resident skin bacteria on the scalp by suppressing the bactericidal effect on Staphylococcus captis, which is a resident skin bacteria on the scalp. Specifically, a scalp resident skin bacteria control agent that uses a specific bactericidal component in combination with an antiperspirant component does not produce a bactericidal effect that exceeds the bactericidal effect of the bactericidal component or antiperspirant component that has a relatively high bactericidal effect on Staphylococcus captis, so it is beneficial in that it can suppress the bactericidal effect on resident skin bacteria on the scalp and suppress the imbalance of resident skin bacteria on the scalp. The bactericidal effect can be confirmed by a test using the diffusion method (perforated plate method) described below. In addition, a combination of a specific bactericidal component and an antiperspirant component is useful for suppressing scalp odor because it can suppress the metabolism of Staphylococcus captis, a normal flora of the scalp. In addition, a combination of a specific bactericidal component and an antiperspirant component is useful for suppressing scalp odor because it can suppress odor for a long time and has a sustained suppression effect, so it is particularly useful for not worrying about odor.

[0088] Furthermore, if the balance of normal skin bacteria on the scalp is disrupted, the health of the scalp will deteriorate, hair loss will be promoted, and normal hair growth may be inhibited. The present invention can suppress the disruption of the balance of normal skin bacteria on the scalp by suppressing the bactericidal effect on Staphylococcus captis, a normal skin bacteria on the scalp. Therefore, the scalp antiperspirant composition of the present invention may be included in hair cosmetics applied to the scalp for hair growth, hair nourishment, hair growth, hair growth promotion, hair loss prevention, thinning hair improvement, fine hair improvement, soft hair improvement, and dandruff prevention or improvement.

[0089] In addition, when the scalp sweats, the hair or hat causes steaming, which not only affects the balance of the normal bacteria on the skin and generates odor, but also easily causes itching and discomfort. The present invention is an antiperspirant composition for the scalp that is useful for the scalp, and is therefore suitable for use, for example, when wearing a hat (especially when worn for a long time), before styling hair in the morning, in close contact with people, before and after exercise, when changing mood, and the like, in addition to use during periods of high temperature and humidity.

[0090] <Method> The present invention includes a method for controlling scalp resident bacteria using at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and an antiperspirant component.The present invention also includes a method for suppressing scalp odor using at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and an antiperspirant component.The present invention also includes a method for suppressing dripping of an antiperspirant composition for scalp using at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and an antiperspirant component. EXAMPLES

[0091] The present invention will be described in more detail below based on examples, but the present invention is not limited to these examples.

[0092] [Test Example 1. Bactericidal Effect Evaluation Test] In order to evaluate the bactericidal effect of the present invention against resident skin bacteria on the scalp, Staphylococcus captis was prepared as the resident skin bacteria on the scalp, isopropylmethylphenol, benzalkonium chloride, and hinokitiol were prepared as bactericidal ingredients, and aluminum chlorohydrate and zinc paraphenolsulfonate were prepared as antiperspirant ingredients, and a test was performed using the following diffusion method (perforated plate method).

[0093] Staphylococcus captis bacterial liquid about 10 6 The bacteria were spread onto MH agar medium (Mueller-Hinton agar medium, petri dish diameter 9 cm) inoculated with CFU / mL, and a hole with a diameter of 8 mm was opened in the agar medium using a sterilized punch (TOYOBO, biopsy punch 8 mm, stainless steel). Each test sample shown in Table 1 was poured into the hole to fill it (approximately 0.1 g), and cultured at 33°C for 24 hours. After culture, the diameter (mm) of the inhibition zone was measured, and the average value (n=3) was calculated. The results are shown in Table 1.

[0094] [Table 1]

[0095] From the test results shown in Table 1, it was confirmed that, as in Example 1-1, when benzalkonium chloride and zinc paraphenolsulfonate are used in combination, there is no additive bactericidal effect on scalp resident skin bacteria.Specifically, compared to the size of the inhibition circle in Comparative Example 1-4, which contains only benzalkonium chloride as a bactericidal component, the size of the inhibition circle in Example 1-1, which uses benzalkonium chloride as a bactericidal component and zinc paraphenolsulfonate as an antiperspirant component in combination, is not enlarged, and it was confirmed that there is no additive bactericidal effect.

[0096] In addition, from the test results shown in Table 1, it was confirmed that the combined use of isopropyl methylphenol and aluminum chlorohydrate as in Example 1-2 does not produce an additive bactericidal effect against the scalp's resident skin bacteria. Specifically, compared to the size of the inhibition circle in Comparative Example 1-5, which contains the bactericidal component isopropyl methylphenol alone, the size of the inhibition circle in Example 1-2, which uses the bactericidal component isopropyl methylphenol in combination with the antiperspirant component chlorohydroxyaluminum, is not enlarged, and it was confirmed that no additive bactericidal effect is produced.

[0097] In addition, from the test results shown in Table 1, it was confirmed that the combined use of benzalkonium chloride and aluminum chlorohydrate as in Example 1-3 does not produce an additive bactericidal effect against the scalp's resident skin bacteria. Specifically, compared to the size of the inhibition circle in Comparative Example 1-4, which contains only benzalkonium chloride, a bactericidal component, the size of the inhibition circle in Example 1-3, which uses benzalkonium chloride, a bactericidal component, in combination with aluminum chlorohydrate, an antiperspirant component, is not enlarged, and it was confirmed that no additive bactericidal effect is produced.

[0098] In addition, from the test results shown in Table 1, it was confirmed that, as in Example 1-4, when isopropyl methylphenol and zinc paraphenolsulfonate are used in combination, there is no additive bactericidal effect on the scalp's resident skin bacteria. Specifically, compared to the size of the inhibition circle in Comparative Example 1-2, which contains only zinc paraphenolsulfonate, the component that formed the inhibition circle, among isopropyl methylphenol and zinc paraphenolsulfonate, the size of the inhibition circle in Example 1-4, which uses isopropyl methylphenol, a bactericidal component, and paraphenolsulfonic acid, an antiperspirant component, in combination, is not enlarged, and it was confirmed that there is no additive bactericidal effect.

[0099] Thus, according to Examples 1-1 to 1-4, no additive bactericidal effect is produced against Staphylococcus captis, a normal skin flora on the scalp, and therefore the ecological balance of normal skin flora on the scalp is less likely to be disrupted and is easier to maintain.

[0100] On the other hand, from the test results shown in Table 1, it was confirmed that, as in Comparative Example 1-7, when hinokitiol and zinc paraphenolsulfonate are used together, an additive bactericidal effect occurs against the resident skin bacteria of the scalp. Specifically, compared with the size of the inhibition circle in Comparative Example 1-3, which contains only hinokitiol, a bactericidal component, the size of the inhibition circle in Comparative Example 1-7, which uses hinokitiol, a bactericidal component, and zinc paraphenolsulfonate, an antiperspirant component, in combination, is enlarged, and it was confirmed that an additive bactericidal effect occurs.

[0101] In this way, Comparative Example 1-7 produces an additive bactericidal effect against Staphylococcus captis, a normal skin flora on the scalp, and therefore can be said to be likely to disrupt the ecological balance of normal skin flora on the scalp, making it difficult to maintain this balance.

[0102] From the above, it has been confirmed that when a bactericidal component and an antiperspirant component are used in combination, depending on the type of each component, an additive bactericidal effect is produced, which disrupts the ecological balance of resident skin bacteria on the scalp. On the other hand, according to the present invention, since no additive bactericidal effect is produced, it is difficult to disrupt the ecological balance of resident skin bacteria on the scalp and it is easy to maintain this balance.

[0103] [Test Example 2. Evaluation of sebum's inhibition of bacterial metabolism] It is known that triglycerides in sebum are metabolized by skin resident bacteria to generate odor-causing substances.Therefore, in order to evaluate the bacterial metabolism suppression effect of the present invention on scalp resident skin bacteria, triolein is prepared as the triglyceride, which is the main component of sebum, Staphylococcus captis is prepared as scalp resident skin bacteria, isopropylmethylphenol, benzalkonium chloride and hinokitiol are prepared as bactericidal components, and chlorohydroxyaluminum and zinc paraphenolsulfonate are prepared as antiperspirant components, and the following test is carried out.

[0104] Tryptosoy agar medium (Petri dish, diameter 9 cm) with triolein 0.005cc / cm 2 and Staphylococcus capitis at a bacterial count of 6.5 x 10 5 / cm 2 A bacterial solution adjusted to the desired concentration was applied to each dish, and then 0.3 cc of each test sample shown in Table 2 below was applied to each dish. After culturing at 35°C for 3 days, the samples were extracted with ether, and the amount of oleic acid in each extract was quantified using gas chromatography (GC-MS) analysis under the measurement conditions described below. In addition, the amount of oleic acid, which causes scalp odor, increases as triolein is decomposed, so the lower the amount of oleic acid, the more the scalp odor is suppressed.

[0105] <GC-MS Measurement Conditions> · Model: Gas Chromatograph-Mass Spectrometer (GC-MS) manufactured by Agilent Technologies GC: 7890B MS: 5977A Column: HPINNOWAX, 30m, 0.25mm I.D., 0.25μm, manufactured by GL Sciences Carrier gas: He <GC Conditions> Temperature: 80°C ⇒ Temperature increase (20°C / min) ⇒ 260°C (6 minutes) Flow rate: 1 mL / min Injection volume: 1 μL Inlet: 260°C Split ratio: 10:1 Ionization method: Electron Ionization (EI)

[0106] Note: As a blank, except for not applying the bacterial solution and each test sample, the same steps as above were performed to quantify oleic acid. Also, as a control, except for not applying each test sample, the same steps as above were performed to quantify oleic acid.

[0107] The value obtained by subtracting the blank quantification value from the quantification values of each example, each comparative example, and the control was taken as the true oleic acid amount of each example, each comparative example, and the control. Taking the true oleic acid amount of the control as 100, the oleic acid amounts of each example and each comparative example were determined, and the results are shown in Figure 1.

[0108]

Table 2

[0109] From the test results shown in Figure 1, it was confirmed that the combined use of benzalkonium chloride and zinc paraphenolsulfonate in Example 2-1 can suppress the decomposition amount of triolein caused by scalp resident skin bacteria.Specifically, the amount of oleic acid in Example 2-1, which uses benzalkonium chloride and zinc paraphenolsulfonate in combination, is significantly reduced compared to the amount of oleic acid in control, so it was confirmed that the decomposition amount of triolein caused by scalp resident skin bacteria can be suppressed.

[0110] From the results of the bacterial metabolism inhibition evaluation test in Example 2-1 and the results of the bactericidal effect evaluation test in Example 1-1, it was confirmed that the combined use of benzalkonium chloride and zinc paraphenolsulfonate can suppress sweat generation due to the action of the antiperspirant component, while not producing an additive bactericidal effect, and therefore does not disrupt the ecological balance of the resident skin bacteria on the scalp, and can suppress the amount of triolein decomposed by the resident skin bacteria on the scalp, thereby suppressing scalp odor, and is extremely useful as an antiperspirant composition for the scalp.

[0111] On the other hand, from the test results shown in Fig. 1, it was confirmed that the combined use of hinokitiol and chlorohydroxyaluminum in Comparative Example 2-6 and the combined use of hinokitiol and zinc paraphenolsulfonate in Comparative Example 2-7 cannot suppress the decomposition amount of triolein caused by the skin flora of scalp. Specifically, compared to the amount of oleic acid in the control, the amount of oleic acid in Comparative Example 2-6, in which hinokitiol and chlorohydroxyaluminum are used in combination, and in Comparative Example 2-7, in which hinokitiol and zinc paraphenolsulfonate are used in combination, is not reduced, and it was confirmed that the decomposition amount of triolein caused by the skin flora of scalp cannot be suppressed.

[0112] From the results of the bacterial metabolism inhibition evaluation test of Comparative Examples 2-6 in Figure 1 and the results of the bactericidal effect evaluation test of Comparative Examples 1-6 in Table 1, it was confirmed that the combined use of hinokitiol and chlorohydroxyaluminum does not produce an additive bactericidal effect, but cannot suppress the amount of triolein decomposed by scalp resident bacteria, and therefore cannot suppress scalp odor.

[0113] From the results of the bacterial metabolism inhibition evaluation test of Comparative Examples 2-7 in Figure 1 and the results of the bactericidal effect evaluation test of Comparative Examples 1-7 in Table 1, it was confirmed that the combined use of hinokitiol and zinc paraphenolsulfonate produces an additive bactericidal effect, which is likely to disrupt the ecological balance of the resident skin bacteria on the scalp, and cannot suppress the amount of triolein decomposition by the resident skin bacteria on the scalp, and therefore cannot suppress scalp odor.

[0114] From the above, it has been confirmed that when bactericidal component and antiperspirant component are used together, depending on the type of each component, additive bactericidal effect occurs, the ecological balance of the skin flora on scalp is destroyed, and the odor of scalp cannot be suppressed.On the other hand, by using a specific bactericidal component and antiperspirant component together as in the present invention, it is possible to suppress sweat generation and not produce additive bactericidal effect, so that it is difficult to destroy the ecological balance of the skin flora on scalp, and it is easy to maintain it, and it is possible to suppress the decomposition amount of triolein by the skin flora on scalp, so that it is possible to suppress the odor of scalp.

[0115] [Test Example 3. Evaluation of sebum's inhibition of bacterial metabolism] The use of different types of bactericidal components in combination is important from the viewpoint of, for example, exerting a bactericidal effect suitable for various skin conditions such as the amount of sebum present on the skin. Therefore, in order to evaluate the bacterial metabolism inhibitory effect of the present invention when multiple bactericidal components are included, as shown in Table 3, test samples containing a bactericidal component and an antiperspirant component, and test samples in which different types of bactericidal components were further added to the test samples were prepared, and the following tests were performed.

[0116] Tryptosoy agar medium (Petri dish, diameter 9 cm) with triolein 0.005cc / cm 2 and Staphylococcus capitis at a bacterial count of 6.5 x 10 5 / cm 2 The bacterial solution was then applied to each petri dish at 0.3 cc of each test sample shown in Table 3, and the petri dish was incubated at 35°C for 3 days, after which the samples were extracted with ether and the amount of oleic acid in each extract was quantified using gas chromatography (GC-MS). The measurement conditions for gas chromatography (GC-MS) were the same as those in Test Example 2.

[0117] The amount of oleic acid quantified in Comparative Example 3-1 was set at 100 (standard), and the amounts of oleic acid in Examples 3-1 and 3-2 were determined, and the results are shown in FIG.

[0118] [Table 3]

[0119] From the test results shown in Figure 2, it was confirmed that the combination of benzalkonium chloride, isopropyl methylphenol, and zinc paraphenolsulfonate in Example 3-2 can suppress the amount of triolein decomposed by the scalp's resident skin bacteria to the same extent as the combination of benzalkonium chloride and zinc paraphenolsulfonate in Example 3-1. Specifically, for example, since there are bactericidal components such as hinokitiol that cannot suppress bacterial metabolism and conversely promote bacterial metabolism (see Comparative Example 2-3 in Test Example 2), depending on the type of bactericidal component to be combined, the effect of inhibiting bacterial metabolism may be impaired, but it was confirmed that the effect of inhibiting bacterial metabolism is not impaired by the combination of benzalkonium chloride as a bactericidal component, zinc paraphenolsulfonate as an antiperspirant component, and isopropyl methylphenol as a bactericidal component as in Example 3-2.

[0120] From the above, it was confirmed that the combination of benzalkonium chloride, isopropyl methylphenol, and zinc paraphenolsulfonate in Example 3-2 can suppress the amount of triolein decomposed by resident skin bacteria on the scalp, thereby suppressing scalp odor. It was also confirmed that the use of different types of bactericidal components can exert a bactericidal effect suitable for various skin conditions, such as the amount of sebum present on the skin.

[0121] [Test Example 4. Usability evaluation test of the formulation] In order to evaluate the utility of the present invention, the following tests were carried out. A commercially available artificial leather (Idemitsu Technofine, Sapler PBZ13001) measuring 2 cm x 15 cm was coated with 15 μL of jojoba oil (Nikko Chemicals, NIKKOL Jojoba Oil S) and placed approximately vertically, and 5 μL of each formulation example shown in Table 4 was dripped onto it, and the length of drip (cm) after 15 seconds was measured. The results are shown in Table 4. The amounts in the following examples and comparative examples are w / w%.

[0122] [Table 4]

[0123] From the test results shown in Table 4, it was confirmed that, as in Example 4-1 and Example 4-2, the preparation containing benzalkonium chloride and chlorohydroxyaluminum or zinc paraphenolsulfonate can unexpectedly improve sagging.Specifically, the sagging length in Example 4-1, which uses benzalkonium chloride and chlorohydroxyaluminum in combination, and in Example 4-2, which uses benzalkonium chloride and zinc paraphenolsulfonate in combination, is reduced compared to Comparative Example 4-1, Comparative Example 4-2 and Comparative Example 4-3, which are each component alone, so there is no discomfort and it is confirmed that the usability on the scalp is good.

[0124] In addition, from the test results shown in Table 4, it was confirmed that, as in Example 4-3 and Example 4-4, the preparation containing isopropylmethylphenol and chlorohydroxyaluminum or zinc paraphenolsulfonate can unexpectedly improve sagging.Specifically, the sagging length in Example 4-3, which uses isopropylmethylphenol and chlorohydroxyaluminum in combination, and in Example 4-4, which uses isopropylmethylphenol and zinc paraphenolsulfonate in combination, is reduced compared to Comparative Example 4-1, Comparative Example 4-2 and Comparative Example 4-4, which are each component alone, so there is no discomfort and it is confirmed that the usability on the scalp is good.

[0125] Furthermore, from the test results shown in Table 4, it was confirmed that, as in Examples 4-5 and 4-6, preparations containing glycyrrhetinic acid and chlorohydroxyaluminum or zinc paraphenolsulfonate can unexpectedly improve sagging. Specifically, the sagging length in Example 4-5, which uses glycyrrhetinic acid and chlorohydroxyaluminum in combination, and in Example 4-6, which uses glycyrrhetinic acid and zinc paraphenolsulfonate in combination, is reduced compared to Comparative Examples 4-1, 4-2, and 4-5, which use each component alone, so there is no discomfort and it is confirmed that the usability on the scalp is good.

[0126] [Test Example 5. Evaluation of the usability and usability of the formulation] In order to evaluate the usability and usability of the present invention, the same usability evaluation test as in Test Example 4 above (evaluation of the length of drooping of the formulation) and the following usability evaluation test were carried out for each formulation example shown in Table 5. For the evaluation of usability, each formulation example was filled into a general trigger-type spray bottle (spray volume 0.3mL to 0.5mL) that can spray mist, and five expert panelists sprayed one push of each onto the scalp from a distance of 5cm from the scalp, and rated on a 10-point scale from 1 to 10 for three items: "non-sticky scalp," "refreshing scalp," and "quick-drying sensation." A higher number indicates a higher evaluation. The average score of the evaluation results of the five panelists was calculated and evaluated according to the following criteria. The results are shown in Table 5. The blend amounts in the following examples and comparative examples are w / w %. [Evaluation Criteria] ◎: 7 points or more ○: 5 points or more and less than 7 points △: 3.5 points or more and less than 5 points ×: Less than 3.5 points

[0127] [Table 5]

[0128] From the test results shown in Table 5, it was confirmed that, as in Example 5-1, a preparation containing benzalkonium chloride and aluminum chlorohydrate, further containing corn starch powder and l-menthol as a refreshing ingredient, can not only improve the sagging condition but also provide a particularly excellent feeling of use. Also, as in Example 5-2, a preparation containing zinc paraphenolsulfonate and isopropylmethylphenol, further containing talc powder and l-menthol as a refreshing ingredient, can not only improve the sagging condition but also provide a particularly excellent feeling of use. On the other hand, it was confirmed that Comparative Example 5-1, which is different from Example 5-1 only in that it does not contain aluminum chlorohydrate, is inferior to Example 5-1 in both sagging length and feeling of use.

[0129] As described above, according to the present invention, which uses a specific bactericidal component and an antiperspirant component in combination, sweat generation is suppressed, and the balance of the ecosystem of the skin flora on the scalp is not easily disturbed, so that the odor of the scalp can be suppressed. That is, in addition to the odor of sweat on the scalp, the odor of the scalp, such as the oxidized odor caused by the mixture of sweat and sebum, and the fatty acid odor discharged by the decomposition of sebum or the metabolism by the skin flora, can be comprehensively suppressed. In addition, it was confirmed that the composition had the remarkable effect of providing good usability on the scalp. Furthermore, it has been confirmed that in the present invention in which a specific bactericidal component and an antiperspirant component are used in combination, the incorporation of a powder or a cooling component further provides a remarkable effect of providing a good feeling when used.

[0130] Examples of formulations of the scalp antiperspirant composition of the present invention are shown below. The blending amounts in the following formulation examples are expressed in w / w %.

[0131] (Formulation example 1) (liquid) (mist type) Isopropyl methylphenol 0.1% Aluminum chlorohydrate 10% Ethanol 70% Hydroxyethylcellulose 0.2% l-Menthol 0.3% Green Tea Extract 0.1% Fragrance (soap-based) appropriate amount Water remaining

[0132] (Formulation example 2) (Liquid) (Roll-on type) Benzalkonium chloride 0.1% Zinc paraphenol sulfonate 3% Ethanol 50% Hydroxypropyl methylcellulose 0.2% l-Menthol 0.2% l-Menthyl glyceryl ether 0.1% Hamamelis extract 0.1% Rosa multiflora extract 0.1% Aluminum starch octenyl succinate 5% Fragrance (sweet floral) appropriate amount Water remaining

[0133] (Formulation example 3) (liquid) (drop type) Glycyrrhetinic acid 0.1% Aluminum chlorohydrate 15% Ethanol 50% Xanthan gum 0.2% Persimmon tannin 0.1% Green Tea Extract 0.1% Swertia japonica extract 0.1% Paraben 0.2% Water remaining

[0134] (Formulation example 4) (liquid) (brush type) Benzalkonium chloride 0.05% Isopropyl methylphenol 0.1% Zinc paraphenol sulfonate 1% Ethanol 20% Carrageenan 0.3% 1,3-Butylene glycol 10% Cationic cellulose 1% Polyoxyethylene hydrogenated castor oil 0.5% Tocopherol acetate 0.1% Mugwort extract 0.1% Water remaining

[0135] (Formulation example 5) (lotion) (bottle type) Triclosan 0.1% Benzethonium chloride 0.05% Aluminum chloride 5% Diethyl sebacate 2% Liquid Paraffin 2% Sorbitan Monostearate 0.5% Polysorbate 60 0.7% Ethanol 10% Carboxyvinyl polymer 0.2% Phenoxyethanol 0.3% Nylon powder 1% Aloe extract 0.1% Triethanolamine (appropriate amount) Water remaining

[0136] (Formulation Example 6) (Aerosol, (liquid:propellant = 1:1)) Benzalkonium chloride 0.03% Isopropyl methylphenol 0.03% Aluminum chlorohydrate 10% Ethanol 30% l-Menthol 0.1% l-Menthyl glyceryl ether 0.05% Hamamelis extract 0.1% Rosa multiflora extract 0.1% Talc 5% Corn starch 3% Fragrance (fresh citrus) appropriate amount Water remaining DME 50%

[0137] (Formulation Example 7) (Aerosol, (liquid:propellant = 6:4)) Benzethonium chloride 0.03% Trichlorocarbanilide 0.03% Zinc paraphenol sulfonate 2% Ethanol 40% l-Menthol 0.1% l-Menthyl glyceryl ether 0.05% Hamamelis extract 0.1% Chamomile extract 0.1% Nylon powder 5% Aluminum starch octenyl succinate 3% Fragrance (citrus herb type) appropriate amount Water remaining LPG 40%

[0138] (Formulation Example 8) (Dry Shampoo) (Aerosol, (Liquid:Propellant=6:4)) Isopropyl methylphenol 0.01% Zinc paraphenolsulfonate 0.5% Ethanol 30% l-Menthol 0.1% l-Menthyl glyceryl ether 0.05% Hamamelis extract 0.1% Chamomile extract 0.1% Silica 5% Mica 3% Fragrance (verbena type) appropriate amount Water remaining LPG 40%

[0139] (Formulation Example 9) (Dry shampoo) (Mist type) Benzalkonium chloride 0.01% Isopropyl methylphenol 0.01% Aluminum chlorohydrate 1% Ethanol 30% l-Menthol 0.3% Tea extract 0.1% Euonymus extract 0.1% Peony extract 0.1% Talc 5% Mica 3% Fragrance (geranium type) appropriate amount Water remaining

[0140] (Formulation Example 10) (Wipe Sheet) (Sheet base material: cotton, rayon, polyester synthetic fiber) Benzalkonium chloride 0.01% Aluminum chlorohydrate 5% Ethanol 30% Polyoxyethylene polyoxypropylene decyl tetradecyl ether 1% l-Menthol 0.2% Peony extract 0.1% Scutellaria root extract 0.1% Comfrey Extract 0.1% Fragrance (citrus) - appropriate amount Water remaining

[0141] (Formulation Example 11) (Emulsion-impregnated wipes) (Sheet base material: cellulose) Isopropyl methylphenol 0.05% Zinc paraphenol sulfonate 3% Sugar Squalane 2% Caprylic / capric triglyceride 1% Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol 0.3% Methylpolysiloxane 0.5% Xanthan gum 0.1% Polyoxyethylene hydrogenated castor oil 0.5% Lipophilic glyceryl monostearate 0.3% l-Menthol 0.5% Seaweed extract 0.1% Artichoke Extract 0.1% Scutellaria root extract 0.1% Tea dry distillate 0.1% Swertia japonica extract 0.01% Carrot extract 0.01% Cinnamon bark extract 0.01% Water remaining

[0142] (Formulation example 12) (liquid) (mist type) Isopropyl methylphenol 0.05% Zinc paraphenol sulfonate 3% Ethanol 50% Polyoxyethylene polyoxypropylene decyl tetradecyl ether 1% Decaglyceryl (Eicosanedioate / Tetradecanedioate) 0.5% l-Menthyl glyceryl ether 0.2% l-Menthol 0.5% Lysozyme hydrochloride 0.1% Tea dry distillate 0.1% Seaweed extract 0.01% Saxifrage extract 0.01% Tea extract 0.01% Hamamelis extract 0.01% Peony extract 0.01% Fragrance (botanical floral) 0.05% Water remaining< / ph>

Claims

1. An antiperspirant composition for scalp, comprising (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component.

2. 2. The scalp antiperspirant composition according to claim 1, wherein the phenolic bactericidal component is at least one selected from the group consisting of isopropylmethylphenol, triclosan, and trichlorocarbanilide.

3. 3. The scalp antiperspirant composition according to claim 1, wherein the quaternary ammonium salt is at least one selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetyltrimethylammonium chloride, and cetyltrimethylammonium bromide.

4. The scalp antiperspirant composition according to any one of claims 1 to 3, wherein the component (B) is at least one selected from the group consisting of aluminum chlorohydrate, aluminum chloride, aluminum zirconium complex salt, aluminum allantoin chlorohydrate, and zinc p-phenolsulfonate.

5. The scalp antiperspirant composition according to any one of claims 1 to 4, further comprising (C) a powder.

6. The scalp antiperspirant composition according to any one of claims 1 to 5, further comprising (D) a cooling component.

7. The scalp antiperspirant composition according to any one of claims 1 to 6, which is used for controlling resident skin bacteria on the scalp.

8. A method for controlling resident skin bacteria on the scalp using (A) at least one selected from the group consisting of a phenolic bactericidal component, a quaternary ammonium salt, piroctone olamine, glycyrrhetinic acid, and zinc pyrithione, and (B) an antiperspirant component.

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