Signal sensing device

Abstract

To solve the problem that a signal transmitted by a conventional signal sensing device is susceptible to environmental interference.SOLUTION: A signal sensing device includes a body 1 and two signal sensing elements 2, the two signal sensing elements are installed inside the body, an insulation layer I is sandwiched between the two signal sensing elements, the two signal sensing elements respectively have a signal transmission segment 2a and a signal sensing segment 2b electrically connected to each other, the respective signal transmission segments are formed by planar antennas in parallel with each other and also have a meander line type antenna shape, respective vertical projections having the antenna shape are not completely overlapped in a flat surface on which the respective signal transmission segments are in parallel with each other, and a part or the whole of the signal sensing segments is located in an enclosure part in the case that a part of the body forms the enclosure part to surround a measurement object. According to the present invention, the quality of signal transmission can be enhanced.SELECTED DRAWING: Figure 4

Description

Technical Field

[0001] The present invention relates to sensing technology, and particularly to a signal sensing device.

Background Art

[0002] In a conventional method of measuring related signals by surrounding a measurement object, particularly when the signal sensing device is directly incorporated into a living body without providing external wiring to measure biological signals, due to interference in the measurement environment where the signal detection device exists, the sensed signal cannot be efficiently transmitted to the outside. As a result, an external analysis device cannot obtain the corresponding transmission signal, and it becomes impossible to know the physiological state of the living body in real time.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] Based on the above problems, it is necessary to further improve the conventional signal sensing device.

[0005] To solve the above problems, a first object of the present invention is to provide a signal sensing device capable of improving the quality of signal transmission.

[0006] A second object of the present invention is to provide a signal sensing device that can be installed in a living body and can be decomposed over time and absorbed by the living body.

Means for Solving the Problems

[0007] Terms of direction or approximations thereof described throughout the entire text of the specification of the present invention, such as "front", "rear", "left", "right", "upper (top)", "lower (bottom)", "inner", "outer", "side surface", etc., mainly indicate directions on the attached drawings, and each term of direction or approximation thereof is for assisting in the explanation and understanding of each embodiment of the present invention and does not limit the present invention.

[0008] When using the numeral classifier "one" or "a" for parts and components described throughout the entire text of the specification of the present invention, it is merely for convenience and provides the ordinary meaning within the scope of the present invention. It should be read as including one or at least one, and a single concept also includes multiple situations, except for those clearly expressing other meanings.

[0009] The definitions regarding dimensional specifications described throughout the entire text of the present invention are based on FIG. 1 of the present invention. The "length" described refers to the length of the head or extension of the main body (for example, symbol L H or L E ), and is defined along the extension direction of the reference axis Y shown in FIG. 1. The "width" described refers to the width of the head or extension of the main body (for example, symbol W H or W E ), and is defined along the extension direction of the reference axis X shown in FIG. 1. The "thickness" (which can also represent height) described refers to the thickness of the head or extension of the main body (for example, symbol T H or T E ), and is defined along the extension direction of the reference axis Z shown in FIG. 1. Furthermore, for the dimensional adjustment of all dimensional specifications described in the present invention, the adjustment interval can be 0.1 μm. Also, for the frequency adjustment of the "operating frequency" described throughout the entire text of the present invention, the adjustment interval can be 1 MHz. Also, all specific numerical values described in the present invention can have an allowable error range of plus or minus 10%.

[0010] The signal sensing device of the present invention includes a main body and two signal sensing elements. The two signal sensing elements are installed inside the main body, and an insulating layer is sandwiched between the two signal sensing elements. Each of the two signal sensing elements has a signal transmission segment and a signal sensing segment that are electrically connected to each other. Each of the signal transmission segments is composed of a planar antenna that is parallel to each other and has a meandering antenna shape. In a plane where each of the signal transmission segments is parallel to each other, the vertical projections of the antenna shapes do not completely overlap. When a part of the main body is formed as an enclosure to surround the measurement object, a part or all of the signal sensing segment is located in the enclosure.

[0011] Thereby, the signal sensing device of the present invention can enhance the signal transmission effect by the meandering antenna shape of the signal transmission segment and the arrangement in a non-overlapping (dislocation) manner.

[0012] Also, the antenna shape has a meandering line width between 0.05 and 0.55 mm, a meandering line interval between 1 and 4 mm, a total meandering line width and a total meandering line length between 5 and 20 mm respectively, and a thickness between 0.005 and 0.1 mm. Preferably, the meandering line width is between 0.15 and 0.2 mm, the meandering line interval is between 2 and 3 mm, the total meandering line width and the total meandering line length are between 14 and 16 mm respectively, and the thickness range is between 0.01 and 0.015 mm. In this way, by arranging the signal transmission segment in the above-mentioned specific antenna shape dimensions, when the signal sensing device is installed in the measurement object to sense signals, the signal transmission intensity can be significantly increased.

[0013] Also, the vertical projections of the respective antenna shapes have a dislocation interval without complete overlap, and the dislocation interval is between 0.05 and 2 mm, preferably between 0.1 and 1.5 mm, and more preferably between 0.5 and 1.5 mm. Optionally, in a two-dimensional coordinate system, the X direction and the Y direction are defined, and the vertical projections of the respective antenna shapes do not completely overlap, have a dislocation interval in the X direction, and have a dislocation interval in the Y direction, and the dislocation interval in the X direction and the dislocation interval in the Y direction are between 0.05 and 2 mm. Thus, the intensity of signal transmission can be significantly increased by the arrangement of the dislocation interval.

[0014] Also, the main body has a head portion and an extension portion, and the extension portion is connected to the head portion and extends outward from one end of the head portion with a length, so that the measurement object is surrounded by all or part of the extension portion. Thus, with the arrangement of the head portion and the extension portion, the signal sensing device can be applied to surround the measurement object.

[0015] Also, the signal transmission segment is installed on the head portion of the main body, and the signal sensing segment is installed on the extension portion of the main body. Thus, by arranging the signal transmission segment and the signal sensing segment to correspond to the head portion or the extension portion, the structures of the transmission function and the sensing function of the signal sensing device can be appropriately arranged, so that the transmission signal and the sensing signal can be prevented from interfering with each other.

[0016] Also, the head portion of the main body has a length and a width each between 5 and 35 mm, the extension portion has a width between 2 and 15 mm, and the head portion and the extension portion each have a thickness between 0.05 and 0.350 mm. Thus, with the arrangement of the above-described various dimensional ranges, the signal sensing device can be applied in a specific environment of a limited space (for example, inside a living body of the size of a human body, a rabbit or a mouse, or even a larger-sized living body) and can measure signals for a specific measurement object (organ or tissue).

[0017] Furthermore, it includes a signal amplification part, the signal amplification part has a plurality of protruding structures, the plurality of protruding structures protrude outward from the main body, the shape of the protruding structure is formed in a cylindrical shape, has a diameter between 250 and 400 μm, has a height between 40 and 75 μm, and when a part of the main body forms the surrounding part, the signal amplification part is in contact with the measurement object locally or entirely. Thus, due to the arrangement of the specific shape and dimensions of the protruding structure described above, when the signal sensing device surrounds the measurement object to sense the signal, the intensity of signal sensing can be significantly increased.

[0018] Also, the signal sensing device is made of one or more biodegradable materials. Thus, the signal sensing device of the present invention can be applied to install in vivo to measure a desired sensing signal, and can be completely decomposed within a predetermined period, eliminating the need for another surgery to remove it, thus avoiding the risk of reoperation.

[0019] Also, the main body further has an assembly structure, the assembly structure has a first assembly part and a second assembly part installed on the main body at intervals from each other, and when a part of the main body forms the surrounding part, the first assembly part and the second assembly part are aligned with each other. Thus, when the first assembly part and the second assembly part of the assembly structure are aligned with each other, it can be conveniently and simply coupled to the assembly structure by another fixing member, so that the signal sensing device can be conveniently and simply installed on the measurement object.

[0020] Furthermore, it includes a fixing member, and when the first assembly part and the second assembly part are aligned with each other, the fixing member is coupled to the first assembly part and the second assembly part to maintain the shape of the surrounding part. Thus, by coupling with the assembly structure by the fixing member, the signal sensing device can be fixed to the measurement object.

[0021] Further, the first assembly part and the second assembly part each have at least one through hole. The fixing member has a connecting part, an insertion part, and a locking part. The insertion part extends outward from the connecting part, and the locking part protrudes outward from a position of the insertion part. When the fixing member is coupled to the first assembly part and the second assembly part, the insertion part is inserted into the through hole where the first assembly part and the second assembly part are aligned with each other. The connecting part is located on one side inside the first assembly part and the second assembly part, and the locking part is locked to the other side inside the first assembly part and the second assembly part. In this way, due to the arrangement of the fixing member and the assembly structure, the fixing member and the assembly structure are made simple, and the signal sensing device can be fixed to the measurement object.

[0022] Also, each of the through holes has a through hole diameter in the radial direction. The locking part has an entry end and a locking end. The entry end is located at one end opposite to the connecting part, and the locking end is located between the connecting part and the entry end. The entry end is formed to have a shape that gradually expands toward the locking end, so that in the direction along the axial direction, the length in the radial direction of the locking part gradually increases. In this way, due to the arrangement in which the locking part of the fixing member gradually expands in shape, it can be easily coupled to the assembly structure and has the effect of firmly coupling the fixing member and the assembly structure.

[0023] Further, the first assembly part and the second assembly part each have two through holes, the insertion part of the fixing member forms two protruding structures corresponding to the number of the through holes, and the fixing member has an overall U-shaped or V-shaped form. In this way, since the number of through holes used for assembling the assembly structure is two, and the fixing member has the corresponding number of insertion parts, compared with the state where there is only one through hole and one insertion part, the force can be received more uniformly between the fixing member and the assembly structure, so that the stability of the connection between the fixing member and the assembly structure can be enhanced. Further, compared with the state where the number of through holes and insertion parts is more than two, the merit of space utilization due to the miniaturization of the overall structure can be enhanced, and since the shapes of the fixing member and the assembly structure become relatively simple, the structure is simple and the cost can be reduced.

[0024] In addition, the main body further has a plurality of marking features, and each of the marking features is installed on the main body in alignment with the positions of the first assembly part and the second assembly part. In this way, the convenience of alignment can be enhanced when attaching the assembly structure.

[0025] In addition, each of the marking features is a triangular cut, and the apex of the triangular cut is aligned with the first assembly part and the second assembly part. In this way, the convenience of alignment can be enhanced when attaching the assembly structure.

[0026] In addition, each of the marking features is a linear symbol. In this way, the convenience of alignment can be enhanced when attaching the assembly structure.

Brief Description of the Drawings

[0027]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

Figure 13

Best Mode for Carrying Out the Invention

[0028] In order to further clarify and make the above and other objects, features, and advantages of the present invention more understandable, the embodiments of the present invention will be described in detail below with reference to the drawings. Also, the same reference numerals in different drawings are regarded as the same, and the description thereof will be omitted.

[0029] Figures 1 and 2 are illustrations showing the signal sensing device of an embodiment of the present invention and the state where the signal sensing device surrounds the object to be measured, respectively. The signal sensing device has a main body 1 and a signal sensing element 2. A part of the main body 1 is formed as an enclosing part and used to surround the object to be measured T, and the signal sensing element 2 is installed inside the main body 1. Preferably, the object to be measured T is a structure such as an organ or tissue of a living body. It should be noted that although the object to be measured T shown in Figure 2 is a blood vessel, the object to be measured T is not limited to blood vessels.

[0030] Optionally, the signal sensing device further has a signal amplification part 3 installed on the main body 1. When a part of the main body 1 surrounds the object to be measured T, all or part of the signal amplification part 3 comes into contact with the object to be measured T.

[0031] The main body 1 is used to cover the signal sensing element 2, thereby protecting the signal sensing element 2 and suppressing the interference of the signal sensing element 2 by the sensing environment. Optionally, the main body 1 is formed in a long arrangement and preferably formed to surround the object to be measured T in a relatively wide area. Optionally, the main body 1 is formed in an arrangement having a long and uniform dimension. For example, in the length direction, the width and thickness are each maintained constant. Optionally, as shown in Figures 1 and 2, the main body 1 is formed in a long shape and has a head 1H and an extension part 1E connected to each other. The extension part 1E extends outward from one end of the head 1H with a certain length, and the object to be measured T is surrounded by all or part of the extension part 1E. In particular, the object to be measured T is surrounded by a part of the ring formed by the extension part 1E. When the extension part 1E is formed on the ring, the free end of the extension part 1E or the part close to the free end may be fixed to an appropriate part of the extension part 1E itself, so that the main body 1 can firmly surround the object to be measured T. The fixing method of the extension part 1E can be selected according to the actual situation and is not limited in the present invention.

[0032] Regarding the dimensional arrangement of the main body 1, especially when the signal sensing device is installed inside the human body to measure blood vessels, as shown in Figure 1, corresponding to the directions in which the reference axes X, Y, and Z extend, the head 1H of the main body 1 has a length LH (corresponding to the extending direction of the reference axis Y) and width W H (corresponding to the extending direction of the reference axis X), both are between 5 and 35 mm, preferably between 10 and 30 mm, more preferably between 15 and 20 mm. And thickness T is between 0.05 and 0.35 mm H (corresponding to the extending direction of the reference axis Z). The extending portion 1E has width W E has, and width W E is between 2 and 15 mm, preferably between 5 and 10 mm, and thickness T is between 0.05 and 0.35 mm E has, and the length L of the extending portion 1E E can be arranged according to actual needs.

[0033] As shown in FIG. 1, there is at least one signal sensing element 2, which has a signal transmission segment 2a and a signal sensing segment 2b that are electrically connected to each other, and is installed inside the main body 1. When a part of the main body 1 is formed as an enclosure to surround the measurement object T, a part or all of the signal sensing segment 2a is located in the enclosure. Specifically, the signal transmission segment 2a is located at the head 1H of the main body 1 and can have an arrangement by, for example, an antenna structure, thereby converting a sensing signal generated from the signal sensing segment 2b, particularly a sensing signal generated for the measurement object T, into a transmission signal (for example, an electromagnetic wave) having a specific operating frequency and transmitting it. In particular, it is transmitted to a signal analysis device (not shown), and by converting the transmission signal into the information to be measured correspondingly, related analysis, monitoring, and management are performed. The signal sensing segment 2b is located at the extension 1E of the main body 1 and extends and distributes in the area where the main body 1 is used to surround the measurement object T, thereby receiving the information to be measured (for example, blood flow velocity) in the measurement object T (for example, a blood vessel) and converting the information to be measured into a sensing signal (for example, an electrical signal). Then, by transmitting the sensing signal to the signal transmission segment 2a by the signal sensing segment 2b, the signal transmission segment 2a generates a corresponding transmission signal. Specifically, the transmission signal can be transmitted to a corresponding receiving unit (not shown), and the receiving unit analyzes the received transmission signal based on a predetermined method, thereby converting the transmission signal into the information to be measured of the measurement object T and observing, analyzing, monitoring, or managing the change of the information to be measured.

[0034] Specifically, the antenna structure is formed in the arrangement of a flat antenna (Flat Antenna / Planar Antenna). The operating frequency is determined by the antenna pattern of the signal transmission segment 2a. In other words, with the same material and dimensions, different operating frequencies can be obtained with different antenna patterns. The antenna pattern is composed of, for example, at least one of a square loop, a circular loop, a triangular loop, an asymmetric loop, and other patterns. According to the research of the present invention, when the signal sensing device of the present invention is installed in the human body, if the operating frequency is between 350 MHz and 450 MHz, a preferable transmission effect can be achieved. More preferably, the operating frequency is between 401 MHz and 406 MHz. In this way, within the range of the operating frequency, the signal transmission segment 2a can transmit signals with stable signal quality.

[0035] Optionally, as shown in FIG. 3, the number of signal sensing elements 2 may be plural, and an insulating layer I can be provided between each signal sensing element 2. By isolating the signal sensing elements 2 with the insulating layer I, signal interference between each signal sensing element 2 can be avoided. Preferably, the number of signal sensing elements 2 is two, and the insulating layer I is sandwiched between the two signal sensing elements 2. Corresponding to the arrangement directions of the length (reference axis X), width (reference axis Y), and thickness / height (reference axis Z) of the main body 1, the thicknesses of both the signal transmission segment 2a and the signal sensing segment 2b of the signal sensing element 2 are between 0.005 and 0.1 mm. In the dimensional arrangement of the length and width of the signal transmission segment 2a and the signal sensing segment 2b, they are respectively arranged corresponding to the head portion 1H and the extension portion 1E of the main body 1. In particular, the dimensions in both length and width are smaller than those of the head portion 1H and the extension portion 1E, whereby the signal sensing element 2 can be installed inside the main body 1.

[0036] In particular, as shown in FIGS. 3 to 5, according to the research of the present invention, the number of signal sensing elements 2 is two, and the signal transmission segments 2a of each signal sensing element 2 are composed of planar antennas parallel to each other, and have an antenna shape of a meander line type. When an insulating layer I is interposed therebetween so as to overlap each other (in the direction of the reference axis Z), and the antenna shapes of each other are arranged in a dislocation manner, especially when each signal transmission segment 2a is in a plane parallel to each other (such as in the plane direction composed of the reference axes X and Y), when the perpendicular projections of the antenna shapes do not completely overlap, the signal sensing element can be appropriately applied inside the human body, and thereby the measured sensing signal can be converted into a high-quality transmission signal. Specifically, as shown in FIG. 4, the meander line width W W of the meander line type antenna shape is in the range of 0.05 to 0.55 mm, preferably in the range of 0.09 to 0.25 mm, and more preferably in the range of 0.15 to 0.2 mm. The meander segment interval G M is in the range of 1 to 4 mm, preferably in the range of 2 to 3 mm. The total width W M of the meander segment is in the range of 5 to 20 mm, preferably in the range of 14 to 16 mm. The length L M of the meander segment is in the range of 5 to 20 mm, preferably in the range of 14 to 16 mm. The range of the meander segment line thickness is in the range of 0.005 to 0.1 mm, preferably in the range of 0.01 to 0.05 mm, and more preferably in the range of 0.01 to 0.015 mm. It should be noted that the dimensions of each orientation of the meander segment antenna, especially the dimensions in the corresponding orientation of the head 1H, are smaller than those of the main body 1. Preferably, as shown in FIG. 5, the perpendicular projections of the antenna shapes do not completely overlap and have a dislocation interval M A , and the range of the dislocation interval M A is in the range of 0.05 to 2 mm, preferably in the range of 0.1 to 1.5 mm, and more preferably in the range of 0.5 to 1.5 mm. Optionally, the dislocation interval M A can be dislocated in the X direction and the Y direction, and the dislocation interval M AX in the X direction and the dislocation interval in the Y direction MAyis used for display, and further the dislocation interval M A is the dislocation interval M in the X direction AX and the dislocation interval M in the Y direction Ay constitute a length (M A 2 = M AX 2 + M Ay 2 ), and the dislocation interval M in the X direction AX and the dislocation interval M in the Y direction Ay are both in the range of 0.05 to 2 mm, preferably in the range of 0.1 to 1.5 mm, and more preferably in the range of 0.5 to 1.5 mm.

[0037] Referring to Table 1, they are the numerical values of reflection loss (return loss) and antenna efficiency obtained by the arrangement and dimension design of various antennas. In Table 1, Arrangements 1 to 3 are the numerical values of the antennas designed and published by the research team of Stanford University for the signal sensing device in human blood. In particular, the antenna shape is a loop shape (Spiral Antenna), and it is the arrangement of a square loop as shown in FIG. 6 (indicated by a single antenna AN). Also, the parts of the data that cannot be obtained / estimated are displayed as "No Data". In Table 1, Arrangements 4 to 7 are the research data of the present invention.

[0038]

Table 1

[0039] As can be seen from Table 1, Arrangement 4 submitted by the present invention has the best effect. Arrangement 4 is an arrangement based on the meandering line type antenna shape of the signal transmission segment 2a. In particular, the range of the meandering line width W W is between 0.15 and 0.2 mm, the range of the meandering line interval G M is between 2 and 3 mm, the range of the total width of the meandering lines W M is between 14 and 16 mm, the range of the total length of the meandering lines L A is between 14 and 16 mm, the range of the thickness is between 0.01 and 0.015 mm, and the dislocation interval M AThe range is arranged between 0.5 and 1.5 mm.

[0040] It should be noted that the preferred operating frequencies (401 - 406 MHz) described in the present invention are defined in correspondence with the transmission specifications of existing medical communication devices, and since this frequency band belongs to a low range in wireless transmission, it has a better transmittance. Furthermore, regarding the antenna efficiency, in the process of actual application of the device of the present invention, it is installed within a few centimeters, and further within 1 centimeter, under the skin. Also, according to the research of the present invention, when the antenna efficiency is higher than about 0.010%, the transmitted signal strength can ensure the overall stability of the signal, so that the corresponding transmitted signal can be received by the receiving equipment installed outside the body.

[0041] In an embodiment where the signal sensing device has a signal amplification unit 3, as shown in FIGS. 1, 2, and 7, the signal amplification unit 3 has a plurality of protruding structures 31 and is protrudingly provided on one outer side of the main body 1. The plurality of protruding structures 31 protrude outward from the said outer side of the main body 1, thereby forming the shape of a plurality of protrusions. When a part of the main body 1 forms an enclosing part to surround the measurement object T, a part or all of the signal amplification unit 3 is located in the enclosing part, and the signal amplification unit 3 is in contact with the measurement object T locally or entirely. Specifically, as shown in FIG. 1, in the state where the signal sensing device of the present invention is placed and unfolded on one plane, the plurality of protruding structures 31 protrude in a direction away from the main body 1 from the main body 1. In particular, the signal amplification unit 3 is protrudingly provided on the extension part 1E of the main body 1 and is formed to be aligned with the signal sensing segment 2b of the signal sensing element 2. Thus, when the main body 1 surrounds the measurement object T, the plurality of protruding structures 31 of the signal amplification unit 3 are in contact with the measurement object T locally or entirely, so that the signal amplification unit 3 can be in closer contact with the measurement object T, and the information to be measured received by the signal sensing segment 2b can increase the intensity of the corresponding sensing signal. Optionally, the protruding structure 3 has a shape such as a cylindrical shape, a semi-circular shape, a semi-elliptical shape, a trapezoidal shape, etc., but is not limited to the above shapes.

[0042] Preferably, when each protruding structure 31 contacts the object to be measured T, it partially or entirely presses into the object to be measured T. In particular, the state of the press-in means that the object to be measured T is softer than the plurality of protruding structures 31, and as the state of the main body 1 surrounding the object to be measured T changes from a loose state to a tight state, the depth of the dent in the area where the object to be measured T contacts each protruding structure 31 that contacts the object to be measured T changes from shallow to deep. It should be noted that the state of the press-in preferably does not affect the normal function of the object to be measured T and does not damage the object to be measured T in principle. In this way, by each protruding structure 31 partially or entirely pressing into the object to be measured T, the contact area between the signal amplification unit 3 and the object to be measured T can be increased, and furthermore, the information to be measured received by the signal sensing segment 2b can increase the intensity of the corresponding sensing signal.

[0043] The length, width, and height of each protruding structure 31 in the signal amplification unit 3 are all between 0.1 and 500 μm. In particular, according to the research of the present invention, when the shape of the protruding structure 31 is cylindrical, the intensity of the sensed signal can be significantly increased. Specifically, in the arrangement where the shape of the protruding structure 31 is cylindrical, its diameter is between 10 and 500 μm, preferably between 250 and 400 μm, and more preferably between 300 and 350 μm. The height is between 1.5 and 100 μm, preferably between 40 and 75 μm, and more preferably 50 μm. There is a gap between each protruding structure 31, and the gap is 1.5 to 5 times the diameter, preferably 2 to 3.5 times.

[0044] It should be noted that based on the shape and dimensions of the protruding structure 31 proposed by the present invention, when the signal sensing device of the present invention measures arterial or venous blood vessel signals, especially when measuring venous blood vessel signals, regardless of whether it is during vasoconstriction or the diastolic phase, the changing trend of the blood flow velocity can be stably obtained. Specifically, as shown in FIG. 8, the signal sensing device having the protruding structure 31 of the present invention surrounds the venous blood vessel (measurement object T) of the living body and measures its signal characteristics, and can measure the proximal blood vessel signal, the distal blood vessel signal, and the normal blood vessel signal. The definition of "proximal" is that a vascular clamp (not shown) is installed on the venous blood vessel to be measured, the blood flow velocity downstream of the clamp is decreased (the signal intensity is decreased), and the signal sensing device is installed downstream of the clamp, and the signal measured at a position about 5 mm away from the vascular clamp. The definition of "distal" is that the signal sensing device is installed downstream of the clamp, and the signal measured at a position about 10 mm away from the vascular clamp. The definition of "normal" is the signal measured by the signal sensing device in a situation where the vascular clamp is not installed and the venous blood vessel to be measured is in a natural state. On the other hand, when compared with a comparative experiment (an experiment published by Stanford University), in the comparative experiment, a pyramid-shaped protruding structure was used, the bottom side (the length of the largest side) of the pyramid-shaped protruding structure was 50 μm, and the minimum distance between the edges of each protruding structure was 40 μm. However, in the comparative experiment, only the change in the blood flow velocity in the artery could be measured. Also, since the vein is the place where thrombosis is most likely to occur after surgery, it is necessary to highly monitor the venous blood vessel signals. However, since the venous blood vessel has smaller blood flow fluctuations / signals compared to the arterial blood vessel, it may be difficult to measure the signals. Therefore, the present invention breaks through the limitation of the comparative experiment that only arterial blood vessel signals can be measured, and makes the measured signals more valuable as a reference. In particular, in the present invention, the state of venous blood vessel occlusion is simulated by a vascular clamp, but the signal sensing device of the present invention can still measure the corresponding blood flow signal, and thereby can reflect the change in the blood flow in the blood vessel to be monitored, so that the application range of blood vessel signal monitoring can be greatly improved. Furthermore, it should be noted that the experiment of the present invention was carried out on the veins of living animals (such as rabbits).In particular, although the diameter of the vein of the living body to be experimented is smaller than that of the human body, since the signal sensing device of the present invention can still measure a decipherable signal with stable quality, it can be further proved that it has excellent performance in signal transmission and sensing effects.

[0045] As shown in FIGS. 9 to 12, another embodiment of the signal sensing device of the present invention is shown, which particularly has an optional assembly structure 11 and a corresponding fixing member 4. As shown in FIG. 9, the main body 1 has an assembly structure 11, and the assembly structure 11 has a first assembly part 11A and a second assembly part 11B. The quantities of the first assembly part 11A and the second assembly part 11B are at least one respectively, and the first assembly part 11A and the second assembly part 11B are installed at intervals from each other. In particular, when the quantity of any one of the first assembly part 11A and the second assembly part 11B is plural, all the plural assembly parts (the first assembly part 11A and / or the second assembly part 11B) are installed at intervals from each other. Preferably, the first assembly part 11A and the second assembly part 11B are installed on the extension part 1E of the main body 1, and the first assembly part 11A is installed at a position near the free end closer to the extension part 1E than the second assembly part 11B.

[0046] As shown in FIGS. 10 and 11, when the main body 1 is formed in an annular shape (for example, by bending), particularly when the main body 1 forms the annular shape and surrounds the object to be measured T, the first assembly part 11A and the second assembly part 11B are arranged so as to be aligned with each other, and particularly are aligned so as to overlap and contact each other. At this time, in order to ensure that the first assembly part 11A and the second assembly part 11B are arranged so as to be aligned with each other, and the main body 1 is to surround and / or fix to the object to be measured T, further, by connecting the first assembly part 11A and the second assembly part 11B with the fixing member 4, the shape of the surrounding part is maintained. Specifically, the connection means that the fixing member 4, the first assembly part 11A and the second assembly part 11B have features of concave parts or convex parts for aligning with each other structurally, and further, for example, can be realized by one or more of snap-fit, structural tension and flexibility.

[0047] Optionally, the first assembly part 11A and the second assembly part 11B each have at least one through hole. The fixing member 4 has a connecting part 41, an insertion part 42 and a locking part 43. The insertion part 42 extends outward from the connecting part 41 and has a free end, and the free end is formed so as to be away from the connecting part 41. The locking part 43 protrudes outward from a position of the insertion part 42 and has a space from the connecting part 41. Preferably, the locking part 43 protrudes from the free end of the insertion part 42. When the fixing member 42 is connected to the first assembly part 11A and the second assembly part 11B, the insertion part 42 is inserted into the through holes where the first assembly part 11A and the second assembly part 11B are aligned with each other, the connecting part 41 is located on one side of the first assembly part 11A and the second assembly part 11B, and the locking part 43 is locked on the other side of the first assembly part 11A and the second assembly part 11B.

[0048] Specifically, as shown in FIGS. 11 and 12, corresponding to the radial direction (such as the plane direction composed of the reference axes X and Y) and the axial direction (such as the direction extending from the reference axis Z) of the through holes, each through hole has a through hole diameter in the radial direction. The connecting portion 41 is located outside the assembly structure 11 and protrudes from the through hole in the radial direction. When the fixing member 4 is coupled to the assembly structure 11 in this way, the connecting portion 41 of the fixing member 4 is located on one side of the assembly structure 11 (i.e., on one side of either the first assembly portion 11A or the second assembly portion 11B) without passing through the through hole. The insertion portion 42 extends in the axial direction, and the shape or contour thereof in the axial direction can pass through the through hole of the assembly structure 11. The locking portion 43 has an entry end 43a and a locking end 43b. The entry end 43a is located at one end opposite to the connecting portion 41 or at one end away from the connecting portion 41. The locking end 43b is located between the connecting portion 41 and the entry end 43a. When the fixing member 4 and the assembly structure 11 are coupled, the locking end 43b of the locking portion 43 is locked to the other side of the assembly structure 11.

[0049] Preferably, the entry end 43a is formed to have a shape that gradually expands toward the locking end 43b. In the direction along the axial direction, the length of the locking portion 43 in the radial direction gradually increases. In this way, by forming the locking portion 43 such that the length in the radial direction gradually expands toward the connecting portion 41, the entry end 43a of the locking portion 43 is easy to insert and easy to pass through the through hole formed such that the first assembly portion 11A and the second assembly portion 11B are superimposed and aligned. Further, after the locking portion 43 passes through the through hole, the locking end 43b protrudes from the through hole in the radial direction. In this way, after the locking portion 43 passes through the through hole, the connecting portion 41 is located on one side of the assembly structure 11, the locking end 43b is locked to the other side of the assembly structure 11, and further, the connecting portion 41 and the locking end 43b respectively protrude from the through hole in the radial direction, so that a non-detachable connection can be formed between the first assembly portion 11A and the second assembly portion 11B. Therefore, the signal sensing device of the present invention can be fixed so as to surround the measurement object T.

[0050] Based on the description of the above assembly structure 11 and the fixing member 4, in the present invention, the number of the through holes may be one or more, and the through holes of the first assembly part 11A and the through holes of the second assembly part 11B can be aligned with each other in terms of the arrangement such as the number, position, and shape according to the design. Further, corresponding insertion parts 42 are also installed on the fixing member 41 corresponding to the arrangement of the through holes. In a preferred embodiment of the present invention, as shown in FIGS. 9 to 12, the first assembly part 11A and the second assembly part 11B each have two through holes, and two protruding structures are formed on the insertion part 42 of the fixing member 4 corresponding to the number of the through holes, and the fixing member 4 has an overall U-shaped or V-shaped configuration. Also, it should be noted that although the number of the through holes of the first assembly part 11A and the second assembly part 11B shown in the drawings of the present invention is two each, it is not limited thereto.

[0051] Specifically, the through hole diameter of the through holes of the first assembly part 11A and the second assembly part 11B is 10% to 30% of the width W of the extension part 1E E preferably 15% to 25%, and more preferably 20%. The centers of the two through holes respectively possessed by the first assembly part 11A and the second assembly part 11B have a spacing of 1.5 to 6 times the through hole diameter, preferably 1.5 to 3 times, and more preferably 1.5 to 2 times. Also, the sum of the through hole diameter and the spacing of the through holes must be smaller than the width W of the extension part 1E where it is installed E must be smaller.

[0052] Optionally, as shown in FIGS. 9 to 11, the main body 1 can further have a plurality of marked features M, and each marked feature M is installed on the main body 1 so as to be aligned with the positions of the first assembly part 11A and the second assembly part 11B, thereby marking / indicating the positions of the first assembly part 11A and the second assembly part 11B. Each marked feature M is a cut, preferably a triangular cut, and more preferably, the apex of the triangle is aligned with the first assembly part 11A and the second assembly part 11B.

[0053] Optionally, as shown in FIG. 13, each of the landmark features M consists of a line-type mark, preferably a straight-line mark, and optionally extends to the side of the main body 1 or is installed only on the side of the main body 1. When the first assembly part 11A and the second assembly part 11B are aligned, the straight-line marks of the first assembly part 11A and the second assembly part 11B are connected in a straight line on the side of the main body 1. The side of the main body 1 refers to at least one of the two opposite sides in the width direction, or at least one of the two opposite sides on the reference axis X as shown in FIG. 11, or in the state where the main body 1 forms the surrounding part, the surrounding part refers to at least one of the two opposite sides in the axial direction. In particular, each of the landmark features M used for alignment is located on the same one side of the main body 1.

[0054] When aligning the landmark features M of the first assembly part 11A and the second assembly part 11B by the above-described landmark features M, for example, when the cuts overlap (as shown in FIGS. 9 to 11), or when the linear symbols are arranged in a specific pattern (as shown in FIG. 13), the first assembly part 11A and the second assembly part 11B already represent that they are aligned. Therefore, when the user installs the signal sensing device of the present invention on the measurement object T, by more easily aligning the first assembly part 11A and the second assembly part 11B by the landmark features M, the main body 1 can be fixed to the measurement object T.

[0055] It should be noted that the landmark feature M is a visually different mark from the main body 1 (especially different from the main body 1 and the measurement object T), and is, for example, an indicative feature formed by any one or any combination of colors, characters, symbols, patterns, arrangements of symbols and structures (such as protrusions or cuts), or a distinguishable feature. Therefore, the form of the landmark feature M is not limited to the above-described cuts (as shown in FIGS. 9 to 11) and linear symbols (as shown in FIG. 13).

[0056] According to the structural arrangement of the signal sensing device of the present invention described above, the signal sensing device can be entirely (especially completely) made of biodegradable materials, particularly biodegradable materials approved by the US Food and Drug Administration (FDA). In this way, the signal sensing device can be particularly installed in the body of a target organism and can decompose within a predetermined period, avoiding the risk of reoperation without the need for surgery to remove it. The predetermined period is, for example, 3 to 26 weeks, preferably 13 to 26 weeks. However, the predetermined period can be changed according to conditions such as material and thickness according to the actual required period of signal monitoring, and is not limited to the above-exemplified time. As a specific application example, the signal sensing device can be implanted into the human body to measure the blood flow velocity of a blood vessel (corresponding to the measurement object T) (corresponding to the information to be measured as described above).

[0057] Regarding the biodegradable material, the main body 1 and the insulating layer I may be composed of at least one of polyhydroxybutyric acid (PHB), polyhydroxyvaleric acid (PHV), and poly-L-lactic acid (PLLA). The signal sensing element 2 is made of a biodegradable metal and may preferably be made of magnesium metal. The signal amplification unit 3 can be selected from polycaprolactone (PCL). The fixing member 4 can be selected from polydioxanone and L-lactide glycolide polymer.

[0058] It should be noted that the thickness of the main body 1, particularly the thickness T of the head 1H H and the thickness T of the extension 1E E refer to the overall thickness formed including the signal sensing element 2 sandwiched by the main body 1 and other optional members (such as the insulating layer I).

[0059] In summary, the signal sensing device of the present invention can enhance the signal transmission effect through the meandering antenna shape of the signal transmission segment and the arrangement by the dislocation method. The protruding structure of the signal amplification part is protruded on the extension part of the main body and is aligned with the signal sensing segment located on the signal sensing element of the extension part of the main body, so that the information to be measured received by the signal sensing segment can enhance the intensity of the corresponding sensing signal. Further, when the shape of the protruding structure is cylindrical, with a diameter of about 250 - 400 μm and a height of about 40 - 75 μm, the intensity of the sensing signal can be further enhanced. Also, due to the dimensional arrangement of the main body, the signal sensing element, and the signal amplification part, it can be applied to the measurement of signals in specific organs or tissues inside a living body (especially the human body), particularly the measurement of signals in blood vessels. Moreover, the signal sensing device of the present invention can be entirely made of biodegradable materials, and due to its overall dimensional arrangement, it is suitable for installation in the human body, can measure the desired sensing signal, and can be completely decomposed within a predetermined period, thus avoiding the risk of reoperation without the need for surgery for removal. Additionally, since it can be coupled with the fixing member by the arrangement of the assembly structure, the signal sensing device can be fixed to the object to be measured. Also, the assembly structure can be more easily aligned by the arrangement of the marking features.

[0060] The present invention has been described using the preferred embodiments mentioned above, but they do not limit the present invention. Any person familiar with this technology, as long as they do not deviate from the spirit and scope of the present invention, can still make various changes and modifications to the above-described embodiments and still belong to the technical scope protected by the present invention. Therefore, the protection scope of the present invention should naturally include the meaning described in the appended patent claims and the changes within its equivalent scope.

Explanation of Reference Numerals

[0061] 1 Main body 1H Head 1E Extension part 11 Assembly structure 11A First assembly part 11B Second assembly part 2 Signal sensing element 2a Signal transmission segment 2b Signal sensing segment 3 Signal amplification part 31 Protrusion structure 4 Fixing member 41 Connection part 42 Insertion part 43 Fixing member 43a Inlet end 43b Locking end AN Antenna G M Meandering segment interval I Insulation layer L E Length L H Length L M Total length of meandering segments M Marking feature M A Displacement interval M Az X-direction displacement interval M Ay Y-direction displacement interval T Object to be measured T E Thickness T H Thickness W E Width W H Width W M Total width of meandering segments W W Line width of meandering segments X reference axis direction Y reference axis direction Z reference axis direction

Claims

1. Comprising a main body and two signal sensing elements, the two signal sensing elements are installed inside the main body, an insulating layer is sandwiched between the two signal sensing elements, the two signal sensing elements respectively have a signal transmission segment and a signal sensing segment that are electrically connected to each other, each of the signal transmission segments consists of a planar antenna parallel to each other and has a meandering antenna shape, in a plane where each of the signal transmission segments is parallel to each other, the perpendicular projections of each of the antenna shapes do not completely overlap, When a part of the main body is formed as an enclosure to surround the object to be measured, a part or all of the signal sensing segment is located in the enclosure, and the signal sensing device is characterized in this.

2. The antenna shape has a meandering line width between 0.05 and 0.55 mm, a meandering segment interval between 1 and 4 mm, a total meandering segment width and a total meandering segment length each between 5 and 20 mm, and further has a thickness between 0.005 and 0.1 mm. The signal sensing device according to Claim 1 is characterized in this.

3. The meandering line width is between 0.15 and 0.2 mm, the meandering segment interval is between 2 and 3 mm, the total meandering segment width and the total meandering segment length are each between 14 and 16 mm, and further the thickness range is between 0.01 and 0.015 mm. The signal sensing device according to Claim 2 is characterized in this.

4. The perpendicular projections of each of the antenna shapes have a dislocation interval without completely overlapping, and the dislocation interval is between 0.05 and 2 mm. The signal sensing device according to Claim 1 is characterized in this.

5. The perpendicular projections of each of the antenna shapes have a dislocation interval without completely overlapping, and the dislocation interval is between 0.1 and 1.5 mm. The signal sensing device according to Claim 2 is characterized in this.

6. The perpendicular projections of each of the antenna shapes have a dislocation interval without completely overlapping, and the dislocation interval is between 0.5 and 1.5 mm. The signal sensing device according to Claim 3 is characterized in this.

7. In a two-dimensional coordinate system, the X direction and the Y direction are defined. The vertical projections of the respective antenna shapes do not completely overlap, have a dislocation interval in the X direction, and have a dislocation interval in the Y direction. The dislocation interval in the X direction and the dislocation interval in the Y direction are between 0.05 and 2 mm. The signal sensing device according to claim 1, characterized in that.

8. The main body has a head portion and an extension portion. The extension portion is connected to the head portion and extends outward from one end of the head portion with a single length, so that the measurement object is surrounded by all or part of the extension portion. The signal sensing device according to any one of claims 1 to 7, characterized in that.

9. The signal transmission segment is installed on the head portion of the main body, and the signal sensing segment is installed on the extension portion of the main body. The signal sensing device according to claim 8, characterized in that.

10. The head portion of the main body has a length and a width each between 5 and 35 mm. The extension portion has a width between 2 and 15 mm. The head portion and the extension portion each have a thickness between 0.05 and 0.350 mm. The signal sensing device according to claim 9, characterized in that.

11. Further includes a signal amplification portion. The signal amplification portion has a plurality of protruding structures. The plurality of protruding structures protrude outward from the main body. The shape of the protruding structure is formed in a cylindrical shape, has a diameter between 250 and 400 μm, and has a height between 40 and 75 μm. When a part of the main body forms the surrounding portion, the signal amplification portion is in contact with the measurement object locally or entirely. The signal sensing device according to any one of claims 1 to 7, characterized in that.

12. The diameter of the protruding structure is between 300 and 350 μm, and the height of the protruding structure is 50 μm. The signal sensing device according to claim 11, characterized in that.

13. The signal sensing device is made of one or more biodegradable materials. The signal sensing device according to any one of claims 1 to 7, characterized in that.

14. The main body further has an assembly structure, and the assembly structure has a first assembly part and a second assembly part that are installed on the main body at intervals from each other. When a part of the main body forms the surrounding part, the first assembly part and the second assembly part are aligned with each other. The signal sensing device according to any one of claims 1 to 7, characterized in that.

15. Further including a fixing member, when the first assembly part and the second assembly part are aligned with each other, the fixing member is combined with the first assembly part and the second assembly part to maintain the shape of the surrounding part. The signal sensing device according to claim 14, characterized in that.

16. The first assembly part and the second assembly part each have at least one through hole. The fixing member has a connecting part, an insertion part, and a locking part. The insertion part extends outward from the connecting part, and the locking part protrudes outward from one position of the insertion part. When the fixing member is combined with the first assembly part and the second assembly part, the insertion part is inserted into the through hole where the first assembly part and the second assembly part are aligned with each other. The connecting part is located on one side inside the first assembly part and the second assembly part, and the locking part is locked on the other side inside the first assembly part and the second assembly part. The signal sensing device according to claim 15, characterized in that.

17. Each of the through holes has a through hole diameter in the radial direction. The locking part has an entry end and a locking end. The entry end is located at one end opposite to the connecting part, and the locking end is located between the connecting part and the entry end. The entry end is formed to have a shape that gradually expands toward the locking end. In the direction along the axial direction, the length in the radial direction of the locking part gradually increases. The signal sensing device according to claim 16, characterized in that.

18. The first assembly part and the second assembly part each have two through holes. The insertion part of the fixing member forms two protruding structures corresponding to the number of the through holes. The fixing member has an overall U-shaped or V-shaped shape. The signal sensing device according to claim 16, characterized in that.

19. The body further has a plurality of marking features, and each of the marking features is installed on the body by aligning with the positions of the first assembly part and the second assembly part. The signal sensing device according to claim 14, characterized in that.

20. Each of the marking features is a triangular notch, and the apex of the triangular notch is aligned with the first assembly part and the second assembly part. The signal sensing device according to claim 19, characterized in that.

21. Each of the marking features is a linear symbol. The signal sensing device according to claim 19, characterized in that.

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