Liquid agent filling method

Abstract

To provide a liquid agent feeding method which prevents generation of bubbles when filling a liquid material containing 20 mass % or more and 100 mass % or less of an organic solvent having a boiling point of 85°C or less at a normal pressure by using a pump, and can fill a required amount of the liquid agent into a container.SOLUTION: In a filling method for a liquid agent according to the present invention, an inner part of a sealed tank 28 for storing a liquid agent connected to a suction side piping 24 is pressurized to a predetermined pressure, and a pressure loss ΔP (Pa) in a discharge side piping 26 is set to a range specified by following formula 1. Formula 1 0≤log10(ΔP / ΔPx)≤0.5 ΔPx: pressure (Pa) calculated by log10ΔPx=5.688x+1.909 x: content (mass%) of organic solvent having a boiling point of 85°C or lower at normal pressure in the liquid.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a method for filling a container with a liquid agent containing an organic solvent.

Background Art

[0002] Patent Document 1 below discloses a kit 100 for preparing a multi-component liquid composition that can be suitably used for preparing a dental adhesive composition such as a dental adhesive (see FIG. 6). The preparation kit 100 includes a composite liquid agent package 104 composed of a plurality of liquid agent packages 102 that contain the components of the liquid composition, and an outer bag 106 that houses the composite liquid agent package 104.

[0003] As shown in FIG. 7, the liquid agent package 102 is manufactured by vertically sealing a single film back-to-back to form a tube, performing a horizontal seal at a predetermined interval, and then cutting. The liquid agent is housed inside a "pill flat bag". The liquid agent package 102 has a vertical seal portion 108, an upper horizontal seal portion 110, a lower horizontal seal portion 112, and a liquid agent housing portion 114 provided between the upper horizontal seal portion 110 and the lower horizontal seal portion 112. Note that a through-opening 116 may be provided in the upper horizontal seal portion 110 for the purpose of convenience when heat-sealing the upper horizontal seal portions 110 of a plurality of liquid agent packages 102 in an overlapping manner to form the composite liquid agent package 104.

[0004] When preparing a multi-component liquid composition using the preparation kit 100, the plurality of liquid agent packages 102 that make up the composite liquid agent package 104 are crushed inside the outer bag 106. As a result, each liquid agent package 102 is opened, and the liquid agent flows out from each liquid agent package 102 into the outer bag 106. Then, by mixing the plurality of liquid agents inside the outer bag 106, a multi-component liquid composition can be prepared.

[0005] By the way, a dental adhesive (dental adhesive composition) contains a polymerizable monomer and a chemical polymerization initiator as active ingredients, and these harden to form a highly adhesive film on the surface of an adherend such as dental tissue. Usually, for the purpose of imparting coatability, it is an organic solvent that is excellent in the solubility of the active ingredients and can be easily volatilized by air blowing so as not to inhibit (the action of the active ingredients that gives a hardened body with high strength). Specifically, it is a multi-component liquid composition composed of a solution in which the active ingredients are dissolved in an organic solvent that is liquid at normal temperature and normal pressure and has a boiling point of 85°C or lower at normal pressure. And during dental treatment, each time, a plurality of liquid agents (in which a part of the active ingredients are dissolved in the organic solvent) are mixed to prepare a required amount of dental adhesive composition as needed. Therefore, in the preparation kit 100, if the amount of each liquid agent packaged in the plurality of liquid agent packages 102 is set as the single-use amount, there is an advantage that not only the preparation operation becomes simple but also the amount of the liquid agent that is unused and discarded can be reduced. In such a preparation kit 100 suitable for single use, the amount of the liquid agent filled in each liquid agent package 102 is small. In the case of a dental adhesive composition such as a dental adhesive, the amount of the liquid agent suitable for single use is about 0.01 ml to 1 ml. Such a small amount of liquid agent is generally automatically filled into the liquid agent package 102 (container) using a filling device.

Prior Art Documents

Patent Documents

[0006]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0007] However, when filling a container with a liquid agent containing a relatively large amount of an organic solvent having a boiling point of 85°C or lower at normal pressure using a filling device, bubbles may be generated in the filling device. In this case, even if the filling device sends a required volume of the liquid agent into the container, for example, if bubbles are generated in the suction-side pipe or the pump, the filling amount of the liquid agent will decrease by the volume of the bubbles, and it will not be possible to fill the container with the required amount of the liquid agent. Further, as revealed by the studies of the present inventors, when the discharge-side pipe becomes a certain length, bubbles may be generated in the discharge-side pipe. In such a case, the liquid agent filling the discharge-side pipe is pushed out by the bubbles when the bubbles are generated, or the bubbles remaining discontinuously in the pipe are pushed out, so that the discharge amount at the pump discharge port and the discharge amount at the pipe outlet do not match, and it becomes impossible to fill the container with the required amount of the liquid agent. And the smaller the amount of the liquid agent to be filled, the greater the influence of the bubbles.

[0008] An object of the present invention is to prevent the generation of bubbles during the filling of not only the liquid agent for preparing the dental adhesive composition described above, but also a liquid agent containing 20% by mass or more and 100% by mass or less of an organic solvent having a boiling point of 85°C or lower at normal pressure, and to provide a method for filling a liquid agent that can fill a container with the required amount of the liquid agent.

Means for Solving the Problems

[0009] The present inventors have intensively studied the conditions under which the generation of bubbles during filling can be prevented. Then, it was confirmed that by making the tank in which the liquid agent is stored a sealed tank, pressurizing the sealed tank at a predetermined pressure, and setting the pressure loss in the discharge-side pipe of the pump within a predetermined range, the vaporization of the dissolved air in the liquid agent can be prevented, and the present invention was completed.

[0010] According to the present invention, there is provided a method for filling a liquid agent that solves the above problems. That is, Using a liquid agent filling device having a pump with a suction port and a discharge port, a suction side pipe with one end connected to the suction port, and a discharge side pipe with one end connected to the discharge port, a method for filling a liquid agent containing an organic solvent stored inside a sealed tank connected to the other end of the suction side pipe into a container from the open other end of the discharge side pipe, comprising: The liquid agent contains 20 mass% or more and 100 mass% or less of an organic solvent having a boiling point at normal pressure of 85°C or lower, A method for filling a liquid agent, wherein the inside of the sealed tank is pressurized at a predetermined pressure and the pressure loss ΔP (Pa) in the discharge side pipe is within a range specified by the following formula 1. Formula 1 0 ≦ log 10 (ΔP / ΔP x ) ≦ 0.5 ΔP x : log 10 ΔP x = The pressure (Pa) obtained by 5.688x + 1.909 x: Content rate (mass%) of the organic solvent having a boiling point at normal pressure of 85°C or lower in the liquid agent

[0011] The predetermined pressure is preferably 120 kPa or more and 190 kPa or less in absolute pressure.

[0012] When the content rate of the organic solvent is less than 100 mass%, the remainder of the liquid agent is preferably a liquid or solid compound having a boiling point at normal pressure of 95°C or higher.

[0013] The discharge amount of the pump during filling is preferably 0.01 ml / s or more and 1 ml / s or less, and the length of the discharge side pipe is preferably 0.1 m or more and 5 m or less.

Effect of the Invention

[0014] According to the present invention, while pressurizing the inside of the sealed tank at a predetermined pressure, the pressure loss ΔP in the discharge side pipe is 0 ≦ log 10 (ΔP / ΔP xBy setting the range specified by ≦0.5, even when the liquid preparation contains 20% by mass or more and 100% by mass or less of an organic solvent whose boiling point at normal pressure is 85° C. or lower, generation of bubbles during filling can be prevented, so that a required amount of the liquid preparation can be filled into the container.

Brief Description of the Drawings

[0015]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Embodiments for Carrying Out the Invention

[0016] Hereinafter, a preferred embodiment of the method for filling a liquid preparation according to the present invention will be described with reference to the drawings.

[0017] Examples of the liquid preparation that can be filled by the method for filling a liquid preparation according to the present invention include, for example, a liquid preparation for preparing a dental adhesive composition as needed. Such a liquid preparation can be used to manufacture a container by a vertical pillow packaging method and filled into the manufactured container. Therefore, in the present embodiment, an example of carrying out the method according to the present invention in the vertical pillow packaging method will be described.

[0018] FIG. 1 shows a vertical pillow packaging machine 2 in which the method for filling a liquid preparation according to the present invention can be carried out. In the vertical pillow packaging machine 2, a film roll 6 in which a strip-shaped film 4 as a material for a container (pillow flat bag) is wound in a cylindrical shape is attached, and the container is manufactured while appropriately feeding out the film 4 from the film roll 6.

[0019] Film 4 is a laminated structure. The layer (inner layer) that is located inside when the film 4 is formed in the container is formed of a resin with high heat-sealing property (having heat-sealing property) that serves as a sealing material. The layer (outer layer) that is located outside when the film 4 is formed in the container can be composed of a resin with low heat-sealing property (not having heat-sealing property), an inorganic material, or a composite of both. The film 4 may have an intermediate layer between the inner layer and the outer layer to enhance its functions further.

[0020] In the vertical pillow packaging machine 2, a vertical sealing process, a horizontal sealing process, a liquid agent filling process, and a cutting process are executed.

[0021] (Vertical Sealing Process) In the vertical sealing process, both side ends in the width direction of the strip-shaped film 4 are overlapped and heat-sealed to form a vertical seal portion, and a cylindrical body extending in the vertical direction is formed. Specifically, the film 4 is pulled out from the film roll 6 attached to the vertical pillow packaging machine 2 and intermittently moved to the vertical seal process execution unit 8 (see FIG. 1) of the vertical pillow packaging machine 2 via a plurality of direction-changing rollers (not shown). In the vertical sealing process, while moving the film 4 from top to bottom, a portion where one side end 4a (see FIG. 2) in the width direction of the film 4 and the other side end 4b (see FIG. 2) in the width direction of the film 4 are overlapped is heat-sealed in the vertical seal process execution unit 8. In this way, as shown in FIG. 3, both side ends 4a, 4b in the width direction of the film 4 are overlapped and heat-sealed to form a vertical seal portion 10, and a cylindrical body 12 extending in the vertical direction is formed.

[0022] (Horizontal Sealing Process) After the vertical sealing process is executed, the horizontal sealing process is executed. In the horizontal sealing process, the cylindrical body 12 is heat-sealed along the horizontal direction perpendicular to the vertical direction to provide a horizontal seal portion to the cylindrical body 12. As shown in FIG. 1, the horizontal seal process execution unit 14 of the vertical pillow packaging machine 2 is arranged below the vertical seal process execution unit 8.

[0023] In the horizontal sealing process, the cylindrical body 12 that intermittently moves downward from above is heat-sealed intermittently along the horizontal direction by the horizontal sealing process execution unit 14. By performing the horizontal sealing process, as shown in FIG. 4, a plurality of horizontal seal portions 16 can be provided on the cylindrical body 12 at intervals in the vertical direction. Further, a plurality of containers 18 (pillow flat bags) are formed by the plurality of horizontal seal portions 16.

[0024] FIG. 4 is a schematic diagram of the cylindrical body 12 provided with a plurality of horizontal seal portions 16 at intervals in the vertical direction. Actually, it is obtained by repeating the cycle of "horizontal sealing process → (liquid material filling process described later)" at least two or more times. That is, FIG. 4 is a schematic diagram of a connected body in which a plurality of containers 18 are connected in the vertical direction. Between the horizontal seal portions 16 in the connected body, there is a liquid agent storage portion 18c filled with a predetermined amount of liquid agent (not shown). When the connected body is cut into individual containers 18, the upper portion of the horizontal seal portion 16 below the liquid agent storage portion 18c becomes the lower horizontal seal portion 18b of the container 18. Further, the lower portion of the horizontal seal portion 16 above the liquid agent storage portion 18c becomes the upper horizontal seal portion 18a of the container 18. Note that a circular through-opening 18d is provided near the center of the upper horizontal seal portion 18a.

[0025] Note that the horizontal sealing process can be performed along with the intermittent downward movement of the cylindrical body 12. That is, the time during which the horizontal sealing process is performed (for example, 1.4 seconds) may overlap with the time during which the cylindrical body 12 is moving (for example, 0.8 seconds). However, the time during which the horizontal sealing process is performed and the time during which the cylindrical body 12 is moving do not need to be the same length of time.

[0026] (Liquid agent filling process) In the liquid filling process, while intermittently performing the horizontal sealing process, a liquid agent is filled into the cylindrical body 12 whose lower part is closed by the horizontal seal part 16 during the intervals between the horizontal sealing processes. That is, before performing the heat sealing for forming the upper horizontal seal part 18a, a predetermined amount of the liquid agent is filled into the liquid agent storage part 18c of the container 18 whose lower part is closed by the horizontal seal part 16 (the upper part of the horizontal seal part 16 becomes the lower horizontal seal part 18b) provided in the immediately preceding seal process by the liquid filling device 20. Then, after filling the liquid agent into the liquid agent storage part 18c of the container 18, by performing the horizontal sealing process, the upper part of the container 18 is closed by the horizontal seal part 16.

[0027] The liquid filling device 20 includes a pump 22 having a suction port 22a and a discharge port 22b, a suction side pipe 24 whose one end 24a is connected to the suction port 22a, and a discharge side pipe 26 whose one end 26a is connected to the discharge port 22b.

[0028] The pump 22 is not particularly limited, but a positive displacement pump may be used. Examples of positive displacement pumps include reciprocating pumps such as piston pumps, plunger pumps, and diaphragm pumps, and rotary pumps such as Mono pumps (registered trademark) and screw pumps. From the viewpoint of the accuracy of filling a small amount of liquid agent, it is preferable to use a Mono pump. Examples of Mono pumps include Mono dispensers of the ND type, NDM type, NDL type, NVDL type, and HD type (manufactured by Heishin Sozai Co., Ltd.).

[0029] The material of the suction side pipe 24 and the discharge side pipe 26 connected to the pump 22 is not particularly limited, but it is preferably made of metal or synthetic resin, and particularly preferably made of fluororesin from the viewpoint of solubility resistance to organic solvents in the liquid agent and ease of processing and handling during attachment to the pump 22 and the like. Examples of fluororesins include polytetrafluoroethylene.

[0030] The discharge rate of the pump 22 can be appropriately set according to the specifications of the pump used, the filling volume of the liquid agent, and the manufacturing time. However, if the discharge rate is low, the time required for liquid filling becomes long, which may reduce the production efficiency. If the discharge rate is high, a rapid pressure drop may occur due to the change in the flow velocity during liquid delivery, which may cause the organic solvent to vaporize and generate bubbles. From the viewpoints of production efficiency and suppression of bubble generation, the discharge rate of the pump 22 is preferably 0.01 ml / s or more and 1 ml / s or less, and particularly preferably 0.05 ml / s or more and 0.5 ml / s or less.

[0031] The length and inner diameter of the suction-side pipe 24 are not particularly limited. From the viewpoints of liquid clogging in the pipe of the components in the liquid agent and the handling of the pipe, the length of the suction-side pipe 24 is preferably 0.1 m or more and 5 m or less, and particularly preferably 0.2 m or more and 3 m or less. The inner diameter of the suction-side pipe 24 is preferably 0.05 mm or more and 10 mm or less, and particularly preferably 0.1 mm or more and 5 mm or less.

[0032] The length and inner diameter of the discharge-side pipe 26 are not particularly limited as long as they satisfy the pressure loss ΔP (Pa) shown in the following formula 1. From the viewpoints of liquid clogging in the pipe of the components in the liquid agent and the handling of the pipe, the length of the discharge-side pipe 26 is preferably 0.1 m or more and 5 m or less, and particularly preferably 0.6 m or more and 3 m or less. The inner diameter of the discharge-side pipe 26 is preferably 0.05 mm or more and 10 mm or less, and particularly preferably 0.1 mm or more and 1.5 mm or less.

[0033] In the liquid agent filling device 20, a predetermined amount of liquid agent (for example, 0.05 ml or more and 0.2 ml or less) containing an organic solvent stored inside the sealed tank 28 connected to the other end 24b of the suction-side pipe 24 is filled into the container 18 from the other end 26b of the discharge-side pipe 26 where the opening is located.

[0034] When filling the container 18 with the liquid agent by the liquid agent filling device 20, the inside of the sealed tank 28 is pressurized at a predetermined pressure. Since the filling of the container 18 with the liquid agent is performed intermittently, the pump 22 repeats starting and stopping. When the pump 22 is started, a rapid pressure drop due to a change in the flow rate occurs in the suction side pipe 24, and thus the organic solvent may vaporize and bubbles may be generated. Therefore, by pressurizing the inside of the sealed tank 28 at a predetermined pressure, the generation of bubbles in the suction side pipe 24 is prevented.

[0035] The predetermined pressure applied to the inside of the sealed tank 28 is preferably an absolute pressure of 120 kPa or more and 190 kPa or less. If the pressure applied to the inside of the sealed tank 28 is less than 120 kPa absolute pressure, the organic solvent in the liquid agent may volatilize and bubbles may be generated. On the other hand, if the pressure applied to the inside of the sealed tank 28 exceeds 190 kPa absolute pressure, air is likely to enter the liquid agent and may cause bubble generation. Therefore, the predetermined pressure is preferably an absolute pressure of 120 kPa or more and 190 kPa or less.

[0036] Also, when filling the liquid agent, the pressure loss ΔP (Pa) in the discharge side pipe 26 is set within the range specified by the following formula 1. By this, it is possible to prevent the generation of bubbles due to a change in the flow rate in the discharge side pipe 26. Formula 1 0 ≦ log 10 (ΔP / ΔP x ) ≦ 0.5 ΔP x : log 10 ΔP x = The pressure (Pa) obtained by 5.688x + 1.909 x: The content rate (mass%) of the organic solvent having a boiling point of 85°C or less at normal pressure in the liquid agent

[0037] The above pressure loss ΔP can be obtained by the following formula 2. Formula 2 ΔP = ρgh ρ: The density of the liquid agent (kg / m 3 ) g: The gravitational acceleration (m / s 2 ) h: The loss head (m)

[0038] The above-mentioned loss head h can be calculated from the following Equation 3 (Darcy-Weisbach equation). Equation 3 h=(λLV 2 ) / (2gD) λ: Pipe friction coefficient L: Length of the pipe (m) V: Flow velocity (m / s) g: Acceleration due to gravity (m / s 2 ) D: Inner diameter of the pipe (m)

[0039] The above-mentioned pipe friction coefficient λ can be obtained by the following Equation 4. The following Equation 4 is generally used in the case of laminar flow (when the Reynolds number (Re) is less than 2300). In the liquid filling device 20 of the present embodiment, since it is laminar flow with Re < 2300, the following Equation 4 can be used. Equation 4 λ = 64 / Re

[0040] Also, the Reynolds number Re can be obtained from the following Equation 5. Equation 5 Re = ρVD / μ ρ: Density of the liquid agent (kg / m 3 ) V: Flow velocity (m / s) D: Inner diameter of the pipe (m) μ: Viscosity of the liquid agent (Pa·s)

[0041] log 10 (ΔP / ΔP x ) is less than 0, the pressure loss due to the discharge side pipe 26 becomes insufficient, and the pressure reduction accompanying the change in the flow velocity at the discharge port 22b of the pump 22 cannot be sufficiently suppressed, and the generation of bubbles due to the pressure reduction of the liquid agent is likely to occur. On the other hand, when log 10 (ΔP / ΔP x ) exceeds 0.5, the internal pressure in the discharge side pipe 26 rises, and dripping occurs from the other end 26b of the discharge side pipe 26, which is the filling part to the container 18, and the influence on the filling amount is likely to occur. Furthermore, since the inner diameter of the discharge side pipe 26 to be used is small and long, it may cause liquid clogging of the liquid agent components and the like.

[0042] The liquid agent filled into the container 18 under such conditions may contain 20% by mass or more and 100% by mass or less of an organic solvent having a boiling point of 85°C or lower at normal pressure. When the content of the above organic solvent is less than 100% by mass, the balance other than the liquid agent is not particularly limited, but is usually a liquid or solid compound having a boiling point of 95°C or higher at normal pressure. Examples of the organic solvent having a boiling point of 85°C or lower at normal pressure include alcohols such as methanol, ethanol, and isopropyl alcohol, and ketones such as acetone and methyl ethyl ketone. These organic solvents can also be used in combination of one or more organic solvents.

[0043] When the liquid agent is a liquid agent used for preparing a dental adhesive composition, due to the good performance obtained in terms of solubility in the polymerizable monomer and chemical polymerization initiator (both of which are usually liquid or solid compounds having a boiling point of 95°C or higher at normal pressure and soluble in the organic solvent) as the active ingredients, and the coatability and penetrability to the adherend when using the dental adhesive composition, the content of the above organic solvent is preferably 40% by mass or more and 90% by mass or less, particularly preferably 45% by mass or more and 85% by mass or less. In addition, as the organic solvent having a boiling point of 85°C or lower at normal pressure, acetone, ethanol, isopropyl alcohol, etc. are particularly preferably used for reasons such as biocompatibility and solubility.

[0044] The liquid agent filled into the container 18 under such conditions may contain 20% by mass or more and 100% by mass or less of an organic solvent having a boiling point of 85°C or lower at normal pressure (atmospheric pressure). When the content of the organic solvent is less than 100% by mass, it is preferable that the balance of the liquid agent is a liquid or solid compound having a boiling point of 95°C or higher at normal pressure.

[0045] (Cutting step) After filling the liquid agent storage part 18c with the liquid agent and forming the upper horizontal seal part 18a above the liquid agent storage part 18c, a cutting process for cutting the horizontal seal part 16 is executed. As shown in FIG. 1, the cutting process execution part 30 of the vertical pillow packaging machine 2 is arranged below the horizontal seal process execution part 14. The cutting process is executed in a state where the movement of the cylindrical body 12 moving downward from above is stopped so that a predetermined cutting planned position 32 (see FIG. 4) of the horizontal seal part 16 can be cut. Then, by executing the cutting process in the cutting process execution part 30, as shown in FIG. 5, a container 18 filled with a required amount of the liquid agent can be manufactured.

[0046] As described above, according to the present embodiment, while pressurizing the inside of the sealed tank 28 at a predetermined pressure, the pressure loss ΔP in the discharge side pipe 26 is set in the range specified by 0 ≦ log 10 (ΔP / ΔPx) ≦ 0.5, so that the generation of bubbles during filling can be prevented, and a required amount of the liquid agent can be filled into the container 18.

[0047] (Example) The inventors conducted an experiment of filling a liquid agent into a container (pillow flat bag) using two types of liquid agents (the first agent and the second agent) having different organic solvent contents. Regarding the discharge side pipe, the pressure loss in the discharge side pipe was appropriately adjusted by changing the conditions. <Experimental conditions> Pump used: Mono Dispenser HD type (manufactured by Heishin Equipment Co., Ltd.) Pump discharge rate: 0.2 ml / s (the first agent), 0.16 ml / s (the second agent) Pipe material: Made of polytetrafluoroethylene Suction side pipe: Length 1.0 m, inner diameter 4.0 mm Discharge side pipe: Length 0.2 m to 1.8 m, inner diameter 0.25 mm to 2.0 mm Pressure inside the sealed tank: 151 kPa (absolute pressure) Filling amount: 0.1 mL / time (the first agent), 0.08 mL / time (the second agent) Filling time: 0.5 s / time Number of filling samples: 400

[0048] (Experiment 1) First, as Experiment 1, multiple experiments were conducted to fill the container with the first agent while changing the pressure loss in the discharge-side pipe. The composition of the first agent contains 51% by mass of an organic solvent (acetone) with a boiling point of 85°C or lower at normal pressure, and a total of 49% by mass of a monomer and additives (such as a polymerization initiator), which are liquid or solid compounds with a boiling point of 95°C or higher at normal pressure. Since the content rate of the organic solvent in the first agent is 51% by mass, x = 0.51. Therefore, log 10 ΔP x has the following value. log 10 ΔP x = 5.688x + 1.909 = 5.688 × 0.51 + 1.909 = 4.810

[0049] The results of Experiment 1 are shown in Table 1 below. As can be understood by referring to Table 1, when 0 > log 10 (ΔP / ΔP x ), bubbles are generated, and when 0 ≤ log 10 (ΔP / ΔP x ), no bubbles are generated.

[0050] [Table 1]

[0051] (Experiment 2) Also, as Experiment 2, multiple experiments were conducted to fill the container with the second agent while changing the pressure loss in the discharge-side pipe. The composition of the second agent contains 78% by mass of an organic solvent with a boiling point of 85°C or lower at normal pressure (49% by mass of acetone and 29% by mass of ethanol), and a total of 22% by mass of a monomer, purified water, and a solid additive (such as a polymerization initiator) that is solid at normal pressure. Since the content rate of the organic solvent in the second agent is 78% by mass, x = 0.78. Therefore, log 10 ΔP x has the following value. log 10 ΔP x = 5.688x + 1.909 = 5.688×0.78 + 1.909 = 6.345

[0052] The results of Experiment 2 are shown in Table 2 below. As can be understood by referring to Table 2, when 0 > log 10 (ΔP / ΔP x ), bubbles are generated, and when 0 ≤ log 10 (ΔP / ΔP x ), no bubbles are generated.

[0053]

Table 2

Explanation of Symbols

[0054] 2: Vertical pillow packaging machine 4: Film 4a: One end of the film in the width direction 4b: The other end of the film in the width direction 6: Film roll 8: Vertical sealing process execution unit 10: Vertical sealing part 12: Cylindrical body 14: Horizontal sealing process execution unit 16: Horizontal sealing part 18: Container 18a: Upper horizontal sealing part 18b: Lower horizontal sealing part 18c: Liquid agent storage part 18d: Through opening 20: Liquid agent filling device 22: Pump 22a: Suction port 22b: Discharge port 24: Suction side pipe 24a: One end of the suction side pipe 24b: The other end of the suction side pipe 26: Discharge side pipe 26a: One end of the discharge side pipe 26b: The other end of the discharge side pipe 28: Sealed tank 30: Cutting process execution unit 100: Preparation kit 102: Liquid agent package 104: Composite liquid agent package 106: Outer bag 108: Longitudinal seal part 110: Upper horizontal seal part 112: Lower horizontal seal part 114: Liquid agent storage part 116: Through opening

Claims

1. A liquid agent filling method of filling a liquid agent containing an organic solvent stored inside a sealed tank connected to the other end of the suction side pipe into a container from the other end of the discharge side pipe that is open, using a liquid agent filling device having a pump with a suction port and a discharge port, a suction side pipe with one end connected to the suction port, and a discharge side pipe with one end connected to the discharge port, wherein: the liquid agent contains 20% by mass or more and 100% by mass or less of an organic solvent having a boiling point of 85°C or lower at normal pressure; the inside of the sealed tank is pressurized to a predetermined pressure, and the pressure loss ΔP (Pa) in the discharge side pipe is set within the range specified by the following formula 1. Formula 1 0 ≤ log １０ (ΔP / ΔP ｘ ) ≤ 0.5 ΔP ｘ : log １０ ΔP ｘ = the pressure (Pa) obtained by 5.688x + 1.909 x: content ratio (mass%) of the organic solvent having a boiling point of 85°C or lower at normal pressure in the liquid agent

2. The liquid agent filling method according to claim 1, wherein the predetermined pressure is 120 kPa or more and 190 kPa or less in absolute pressure.

3. The liquid agent filling method according to claim 1, wherein when the content ratio of the organic solvent is less than 100% by mass, the balance of the liquid agent is a liquid or solid compound having a boiling point of 95°C or higher at normal pressure.

4. The liquid agent filling method according to claim 1, wherein the discharge amount of the pump during filling is 0.01 ml / s or more and 1 ml / s or less, and the length of the discharge side pipe is 0.1 m or more and 5 m or less.

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