Emulsion composition

Abstract

To provide an emulsion composition that exhibits an inactivating effect against non-enveloped viruses.SOLUTION: An emulsion composition contains ethanol, an oil agent, and a surfactant. The emulsion composition has a pH of 2 or more and 4.5 or less. The emulsion composition has a viscosity of less than 15 mPa s, as measured using a B-type viscometer (No. 4 rotor, 12 rpm, 25°C).SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an emulsified composition.

Background Art

[0002] Conventionally, an emulsified composition used as a finger disinfectant has been known. Patent Document 1 describes a composition for external use on the skin containing ethanol, an oil agent, polyacrylate crosspolymer-6, and an (acryloyldimethyltaurine ammonium / vinylpyrrolidone) copolymer. It is described that it is used for finger disinfection, sterilization, antiviral, or washing.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] By the way, it is known that viruses include enveloped viruses having a lipid membrane and non-enveloped viruses having no lipid membrane. It is known that disinfection with alcohol is effective against enveloped viruses. On the other hand, it is known that non-enveloped viruses cannot be inactivated by alcohol. An emulsified composition that exhibits an inactivating effect against non-enveloped viruses is required.

Means for Solving the Problems

[0005] The emulsified composition for solving the above problems contains ethanol, an oil agent, and a surfactant, has a pH of 2 or more and 4.5 or less, and has a viscosity measured by a B-type viscometer (No. 4 rotor, 12 rpm, 25°C) of less than 15 mPa·s.

Effects of the Invention

[0006] The emulsified composition of the present invention exhibits an inactivating effect against non-enveloped viruses.

Embodiments for Carrying Out the Invention

[0007] Embodiments embodying the emulsified composition according to the present invention will be described. The emulsified composition contains ethanol, an oil agent, and a surfactant. The emulsified composition has a pH of 2 or more and 4.5 or less. The viscosity of the emulsified composition measured by a B-type viscometer is less than 15 mPa·s.

[0008] Hereinafter, each component constituting the emulsified composition will be described. <Ethanol> There are no particular restrictions on the ethanol, and known ethanol blended in the emulsified composition can be used. By the emulsified composition containing ethanol, the actions of ethanol such as finger disinfection, sterilization, and antiviral action (hereinafter, also collectively referred to as the disinfection effect) can be expressed. Hereinafter, ethanol may also be referred to as the active ingredient. Also, ethanol is a base material of the emulsified composition.

[0009] The content of ethanol is not particularly limited, but it is preferably 40% by mass or more, more preferably 45% by mass or more, and even more preferably 49% by mass or more. Also, it is preferably 80% by mass or less, more preferably 75% by mass or less, and even more preferably 70% by mass or less. When the content of ethanol is within the above numerical range, while preferably expressing the disinfection effect by ethanol, it becomes easier to maintain the emulsified state of the emulsified composition.

[0010] <Oil Agent> There are no particular restrictions on the oil agent, and known oil agents blended in the emulsified composition can be used. Since the emulsified composition is likely to be in a viscous state by containing the oil agent, the usability of the emulsified composition can be improved.

[0011] The oil agent is also called an emollient. An emollient means an oil-soluble component that has the property of smoothly spreading on the surface of the skin and does not cause water to evaporate from the skin. When the emulsified composition contains an emollient, it is expected to have the effect of softening the skin by suppressing water evaporation from the skin and maintaining moisture when using the emulsified composition. Specifically, when using the emulsified composition, moisture can be imparted to the fingers, so it is expected to have the effect of suppressing the coarseness and roughness of the fingers.

[0012] Examples of the oil agent include natural animal and vegetable oils and fats, waxes, higher alcohols, higher fatty acids, hydrocarbons, synthetic ester oils, silicone derivatives, and the like. Specific examples of natural animal and vegetable oils and fats include, for example, olive oil, mink oil, castor oil, palm oil, beef tallow, evening primrose oil, coconut oil, castor oil, cocoa butter, macadamia nut oil, jojoba oil, avocado oil, linseed oil, camellia oil, almond oil, sasanqua oil, corn oil, ginger oil, grape oil, grape seed oil, meadowfoam oil, sunflower oil, rapeseed oil, cinnamon oil, egg yolk oil, sesame oil, wheat germ oil, safflower oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice germ oil, rice bran oil, shea butter, hydrogenated coconut oil, palm kernel oil, candelilla wax, hydrogenated castor oil, etc. As the oil agent, vegetable oil components are preferred, and vegetable oils such as olive oil, castor oil, palm oil, evening primrose oil, coconut oil, castor oil, cocoa butter, macadamia nut oil are more preferred. These vegetable oils are easy to get along with the skin and easy to maintain moisture.

[0013] Specific examples of the wax include, for example, beeswax, lanolin, carnauba wax, candelilla wax, lanolin acetate, liquid lanolin, sugarcane wax, reduced lanolin, POE lanolin alcohol ether, etc.

[0014] Examples of the higher alcohol include linear alcohols and branched-chain alcohols. Specific examples of linear alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, and the like.

[0015] Specific examples of branched-chain alcohols include monostearyl glycerin ether (batyl alcohol), 2-decyltetradecynol, lanolin alcohol, cholesterol, phytosterol, hexyl dodecanol, isostearyl alcohol, octyl dodecanol, and the like.

[0016] Specific examples of higher fatty acids include, for example, lauric acid, palmitic acid, stearic acid, oleic acid, behenic acid, lanolin fatty acid, myristic acid, 12-hydroxystearic acid, undecylenic acid, toluic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid, and the like.

[0017] Specific examples of hydrocarbons include, for example, liquid paraffin, solid paraffin, squalane, petrolatum, ceresin, microcrystalline wax, ozokerite, squalene, isoparaffin, octane, decane, dodecane, isododecane, hexadecane, isohexadecane, and the like.

[0018] Specific examples of the synthetic ester oil include, for example, butyl stearate, hexyl laurate, diisopropyl adipate, diisopropyl sebacate, octyldodecyl myristate, isopropyl myristate, isopropyl palmitate, cetyl isooctanoate, neopentyl glycol dicaprate, isopropyl myristate, cetyl octanoate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, glyceride tri-2-heptylundecanoate, methyl ester of castor oil fatty acid, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, 2-octyldodecyl N-lauroyl-L-glutamate, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, glycerin trioctanoate, glycerin triisopalmitate, isopropyl lanolin fatty acid, hexyl laurate, and the like.

[0019] Specific examples of the silicone derivative include silicone oils such as methyl silicone and methylphenyl silicone. The above oil agents may be used alone or in combination of two or more.

[0020] The content of the oil agent is not particularly limited, but it is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, still more preferably 1.0% by mass or more, and particularly preferably 2.0% by mass or more. Also, it is preferably 7.0% by mass or less, more preferably 5.0% by mass or less, and still more preferably 3.0% by mass or less.

[0021] When the content of the oil agent is within the above numerical range, the emulsion composition is likely to maintain an emulsified state. Also, when the blending amount of the oil agent is 2.0% by mass or more and 3.0% by mass or less, the usability of the emulsion composition is more likely to be improved.

[0022] <Surfactant> Specific examples of the surfactant include, for example, nonionic surfactants. (Nonionic surfactant) Specific examples of the nonionic surfactant include, for example, sugar fatty acid esters such as sucrose fatty acid ester and maltose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester, sorbitan fatty acid esters such as sorbitan stearate and sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan laurate (also referred to as polysorbate 20), polyoxyethylene sorbitan stearate (also referred to as polysorbate 60), polyoxyethylene sorbitan oleate (also referred to as polysorbate 80), fatty acid alkanolamides such as lauric acid diethanolamide, polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether and polyoxyethylene oleyl ether, polyethylene glycol fatty acid esters such as polyethylene glycol monooleate and polyethylene glycol monolaurate, alkyl glycosides such as lauryl glucoside and decyl glucoside, polyglycerol fatty acid esters, polyoxyethylene glycerol fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, polyoxyethylene hydrogenated castor oil (with an average addition mole number of ethylene oxide of 10, 20, 30, 40, 50, 60, 100), glycerol fatty acid esters, polyoxyethylene propylene block copolymers, and the like.

[0023] The above surfactants may be used alone or in combination of two or more. Among these, it is preferable that the surfactant contains polyoxyethylene hydrogenated castor oil with an average addition mole number of ethylene oxide of 30 or more and 50 or less.

[0024] When containing polyoxyethylene hydrogenated castor oil with an average addition mole number of ethylene oxide of 30 or more and 50 or less, it becomes easier to maintain the emulsified state of the emulsified composition. The content of the surfactant is not particularly limited, but it is preferably 0.02% by mass or more, more preferably 0.05% by mass or more, and even more preferably 0.1% by mass or more. Also, it is preferably 5.0% by mass or less, more preferably 3.0% by mass or less, and even more preferably 2.0% by mass or less. When the content of the surfactant is within the above numerical range, it becomes easier to maintain the emulsified state of the emulsified composition.

[0025] <Other components> Depending on the purpose of application, form, use, etc., the emulsified composition may be blended with other components other than the aforementioned components, such as bactericides, antibacterial agents, stabilizers, preservatives, pH adjusters, antioxidants, fragrances, colorants, solvents, etc. For each of these components, known ones blended in the emulsified composition can be used. These components may be used alone or in combination of two or more.

[0026] Specific examples of the bactericide include, for example, cetylpyridinium chloride hydrate, hinokitiol, etc. Specific examples of the antibacterial agent include, for example, parabens, sodium benzoate, triclosan, chlorhexidine hydrochloride, chlorhexidine gluconate, minocycline hydrochloride, isopropylmethylphenol, benzalkonium chloride, benzethonium chloride, etc.

[0027] Specific examples of the stabilizer include, for example, sodium edetate, sodium thiosulfate, sodium sulfite, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate, etc.

[0028] Specific examples of the preservative include, for example, 1,2-dibromo-2,4-dicyanobutane, photosensitizer, isothiazolone derivative, hydantoin derivative, etc. Specific examples of the pH adjuster include, for example, citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, gluconic acid, acetic acid, nitric acid, or chemically possible salts thereof, sodium hydroxide, etc.

[0029] Specific examples of the antioxidant include, for example, tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters, and the like. The fragrance may be a natural fragrance or a synthetic fragrance. It may also be a single fragrance or a compound fragrance.

[0030] Specific examples of the fragrance include, for example, l-menthol, d-carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, star anise oil, cinnamon oil, cinnamaldehyde, mint oil, vanillin, and the like.

[0031] Specific examples of the colorant include, for example, legal dyes such as Green No. 1, Green No. 3, Blue No. 1, Yellow No. 4, Yellow No. 5, Red No. 102, Red No. 3, copper chlorophyllin sodium, titanium oxide, and the like.

[0032] Specific examples of the solvent include, for example, water, alcohols other than ethanol, and the like. The type of water used as the solvent is not particularly limited, and for example, distilled water, pure water, ultrapure water, purified water, tap water, and the like can be used. The type of alcohol used as the solvent is not particularly limited. Water and alcohol can also be mixed and used.

[0033] The emulsion composition preferably does not substantially contain a component that can increase the viscosity of the emulsion composition. Note that not substantially containing means allowing it to be contained at the impurity level.

[0034] For example, it is preferable that the emulsion composition substantially does not contain a thickener, a humectant, a wetting agent, etc. The emulsion composition may contain a thickener, a humectant, a wetting agent, etc. as long as the effects of the emulsion composition are not impaired.

[0035] <Properties of the emulsion composition> pH of the emulsion composition The pH of the emulsion composition is 2 or more and 4.5 or less, preferably 2 or more and 4 or less, more preferably 2.5 or more and 4 or less, and even more preferably 2.5 or more and 3.5 or less.

[0036] When the pH of the emulsion composition is within the above numerical range, the inactivating effect on non-enveloped viruses is preferably exhibited. The pH of the emulsion composition may be within the above numerical range as long as the measured value immediately after the production of the emulsion composition is within the above numerical range.

[0037] Viscosity of the emulsion composition The viscosity of the emulsion composition can be measured using a B-type viscometer. Specifically, the emulsion composition adjusted to 25 ° C is measured for viscosity at a rotational speed of 12 rpm using a No. 4 rotor.

[0038] The viscosity of the emulsion composition is less than 15 mPa·s. The lower limit value of the above viscosity is not particularly limited. The emulsion composition may have a viscosity substantially less than 15 mPa·s. Having a viscosity substantially less than 15 mPa·s means that when the viscosity of the emulsion composition is measured, the viscosity cannot be measured because it is lower than the measurement limit of the B-type viscometer.

[0039] When the viscosity of the emulsion composition is within the above numerical range, the inactivating effect on non-enveloped viruses is preferably exhibited. The viscosity of the emulsion composition may be within the above numerical range as long as the measured value immediately after the production of the emulsion composition is within the above numerical range.

[0040] Emulsion particle size The emulsion particle size in the emulsion composition is not particularly limited. The emulsified particle size is, for example, 8 μm or less. Preferably, the emulsified particle size is 5 μm or less. Preferably, the emulsified particle size is from 0.5 μm to 8 μm, more preferably from 0.5 μm to 5 μm, even more preferably from 0.5 μm to 2 μm, and particularly preferably from 0.5 μm to 1.5 μm.

[0041] When the emulsified particle size of the emulsified composition is within the above numerical range, the inactivating effect against non-enveloped viruses is preferably exhibited. The emulsified particle size can be measured by a known method. The above emulsified particle size is the volume average particle size. Also, for the emulsified particle size of the emulsified composition, it is sufficient that the measured value for the emulsified composition left standing at room temperature for one month or more after production is within the above numerical range.

[0042] <Application form, dosage form, use of the emulsified composition> The application form of the emulsified composition is not particularly limited, and it can be used, for example, as pharmaceuticals, quasi-drugs, cosmetics, and quasi-pharmaceuticals.

[0043] The dosage form of the emulsified composition is not particularly limited, and it can be used, for example, as emulsions, sprays, pastes, ointments, gels, lotions, etc. The uses of the emulsified composition are not particularly limited, and examples include finger disinfectants, alcohol disinfectants, and external skin preparations.

[0044] <Production method of the emulsified composition> The emulsified composition can be produced by a known method. When emulsifying the emulsified composition, for example, a homomixer, a high-pressure emulsification device, etc. can be used. Examples of the high-pressure emulsification device include a wet atomization device, a static fluid mixing device, etc.

[0045] The emulsion composition is preferably emulsified using a high-pressure emulsification device. For example, an emulsion obtained by mixing each component with a homomixer is processed with a high-pressure emulsification device to produce the emulsion composition. Emulsifying using a high-pressure emulsification device is also referred to as high-pressure emulsification treatment. By performing high-pressure emulsification treatment, it becomes easier to obtain an emulsion composition with a smaller emulsion particle size.

[0046] <Actions and Effects> The actions of this embodiment will be described. According to the emulsion composition of this embodiment, by being acidic with a pH of 2 or more and 4.5 or less, non-enveloped viruses can be suitably inactivated.

[0047] The effects of this embodiment will be described. (1) The emulsion composition of this embodiment exhibits an inactivating effect on non-enveloped viruses. For example, it is useful against noroviruses.

[0048] (2) Generally, when the pH of an emulsion is acidic, the emulsion stability tends to decrease. In this regard, the emulsion composition of this embodiment has high emulsion stability while adjusting the pH to be acidic. (3) According to an emulsion composition with an emulsion particle size of 5 μm or less, the inactivating effect on non-enveloped viruses is further improved.

[0049] (4) According to the emulsion composition of this embodiment, while increasing the blending amount of the oil agent, an inactivating effect on non-enveloped viruses can be expected. That is, along with the inactivating effect on non-enveloped viruses, effects by an emollient agent, for example, an effect of suppressing rough skin, can be expected.

[0050] (5) According to an emulsion composition with an oil agent content of 0.1% by mass or more and 7.0% by mass or less, the effect by the emollient agent can be more expected. According to the emulsion composition of this embodiment, in addition to the inactivating effect on non-enveloped viruses, the disinfection effect on enveloped viruses can be preferably expressed.

Example

[0051] The emulsion composition will be described in more detail based on the following examples. Note that the emulsion composition is not limited to the configuration described in the example column. <Preparation of Emulsion Composition> The emulsion compositions of Examples 1 to 4 and Comparative Examples 1 and 2 shown in Table 1 were produced.

[0052]

Table 1

[0053] In Table 1, POE hydrogenated castor oil 40 means polyoxyethylene hydrogenated castor oil with an average addition mole number of ethylene oxide of 40. Also, HPMC (molecular weight 10,000) means hydroxypropyl methylcellulose with an average molecular weight of 10,000.

[0054] (Example 1) An emulsion composition was obtained by mixing each component shown in Table 1 using a homomixer. (Examples 2, 3) An emulsion was obtained by mixing each component shown in Table 1 using a homomixer. The obtained emulsion was filled into a wet micronization device (manufactured by Sugino Machine, Starburst). High-pressure emulsification treatment was performed with the treatment conditions of 200 MPa and 1 pass to obtain an emulsion composition.

[0055] (Example 4) An emulsion was obtained by mixing each component shown in Table 1 using a homomixer. The obtained emulsion was filled into a static fluid mixing device (manufactured by Nanox Co., Ltd., Ramond Nanomixer). High-pressure emulsification treatment was performed under the treatment conditions of 0.8 MPa and 5 passes to obtain an emulsified composition.

[0056] (Comparative Example 1) Each component shown in Table 1 was used in the same manner as in Example 1 to obtain an emulsified composition. The emulsified composition of Comparative Example 1 differs from that of Example 1 in that a thickener and a humectant are blended, and the content of the pH adjuster is different.

[0057] (Comparative Example 2) Each component shown in Table 1 was used in the same manner as in Example 4 to obtain an emulsified composition. The emulsified composition of Comparative Example 2 differs from that of Example 3 in that a thickener is blended, and the device used for high-pressure emulsification treatment is different.

[0058] <Measurement of pH, Viscosity, and Emulsion Particle Size> For the emulsified compositions of Examples 1 to 4 and Comparative Examples 1 and 2, the pH, viscosity, and emulsion particle size were measured. The results are shown in Table 1.

[0059] The pH and viscosity were measured immediately after the production of the emulsified composition. The viscosity was measured using a B-type viscometer. Specifically, the emulsified composition adjusted to 25°C was measured for viscosity at a rotational speed of 12 rpm using a No. 4 rotor.

[0060] The emulsion particle size was measured more than one month after the production of the emulsified composition. Specifically, for Comparative Example 1, the emulsion particle size of the emulsified composition left standing at room temperature for one year after production was measured. For Examples 1 to 4 and Comparative Example 2, the emulsion particle size of the emulsified composition left standing at room temperature for one month after production was measured.

[0061] For the measurement of the emulsion particle size, a particle size distribution measuring device (manufactured by Shimadzu Corporation, SALD-7500nano) was used. The volume average particle size was calculated from the particle size distribution obtained with the measurement range of 7 nm to 800 μm.

[0062] <Inactivation Test> For the emulsified compositions of Examples 1 to 4 and Comparative Examples 1 and 2, a test for confirming the inactivating effect on non-enveloped viruses was conducted according to ASTM E1052-20. Specifically, the following operations were performed for each emulsified composition. Also, the following operations were performed using PBS (phosphate buffered saline) instead of the emulsified composition as a negative control.

[0063] Feline calicivirus (F-9 strain) was cultured by a known operation to obtain a virus suspension. A test solution was prepared by mixing the virus suspension and the emulsified composition at a ratio of 1:9 and reacted at 25°C. After 60 seconds, the reaction was stopped by adding a chemical inactivator (SCDLP medium) to the test solution. Then, the viral infectivity titer (PFU / mL) was determined by the plaque assay method.

[0064] <Evaluation of Inactivation Effect> The ratio of the viral infectivity titer in each emulsified composition to the viral infectivity titer in the negative control was calculated as the ratio to NC. The smaller the ratio to NC, the higher the inactivation effect. The ratio to NC was evaluated according to the following evaluation criteria. The results are shown in Table 1.

[0065] ·Evaluation Criteria ◎ (Good): The ratio to NC is less than 0.3. ○ (Fair): The ratio to NC is 0.3 or more and less than 0.5. × (Poor): The ratio to NC is 0.5 or more.

[0066] <Evaluation Results> Feline calicivirus belongs to the family Caliciviridae, which is a non-enveloped virus. Feline calicivirus is used as an alternative virus for evaluating the inactivating effect on norovirus.

[0067] In Examples 1 to 4, the evaluation of the inactivation effect was all fair or better, and the inactivation effect was confirmed. In particular, in Examples 2 to 4, a higher inactivation effect was confirmed. The emulsified compositions of Examples 1 to 4 contain ethanol, an oil agent, and a surfactant, have a pH of 2 or higher and 4.5 or lower, and have a viscosity of less than 15 mPa·s as measured by a B-type viscometer (No. 4 rotor, 12 rpm, 25°C). According to this emulsified composition, it can be expected to exhibit an inactivating effect against non-enveloped viruses. For example, it can be expected to exhibit an inactivating effect against noroviruses.

[0068] The emulsified compositions of Examples 2 to 4 further have an emulsified particle diameter of 5 μm or less. According to this emulsified composition, it can be expected to exhibit a higher inactivating effect against non-enveloped viruses. For example, it can be expected to exhibit a higher inactivating effect against noroviruses.

Claims

Claim 1 An emulsion composition containing ethanol, an oil agent, and a surfactant, having a pH of 2 or more and 4.5 or less, and having a viscosity of less than 15 mPa·s as measured by a B-type viscometer (No. 4 rotor, 12 rpm, 25°C). Emulsion composition. Claim 2 The emulsion composition according to claim 1, wherein the emulsion particle size is 5 μm or less. The emulsion composition according to claim 1. Claim 3 The emulsion composition according to claim 1 or 2, wherein the content of the oil agent is 0.1% by mass or more and 7.0% by mass or less. The emulsion composition according to claim 1 or 2.

Images