Topical composition

Abstract

To provide a formulation which stably contains zinc and a Scutellaria root extract.SOLUTION: A topical composition comprises a Scutellaria root extract, and contains a citric acid, sodium citrate, and zinc so as to fulfill appropriate conditions.SELECTED DRAWING: None

Description

Technical Field

[0001] The present disclosure relates to an external composition and the like. The contents of all documents described in this specification are incorporated herein by reference.

Background Art

[0002] As shown in Patent Document 1, when zinc gluconate, which is a kind of water-soluble zinc salt, and Eugenia caryophyllata extract are used in combination in a hair-growing composition, cloudiness occurs. However, it is known that this can be suppressed by blending a diester of cyclohexanedicarboxylic acid and polyoxyethylene monoalkyl ether. However, since precipitation that occurs when Eugenia caryophyllata extract and a water-soluble zinc salt are used in combination can only be suppressed by this method, other solutions are desired.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] There was a problem that precipitates occurred over time in a lotion containing Eugenia caryophyllata extract and a water-soluble zinc salt. For this reason, it was necessary to find a method such that no precipitate occurs even when Eugenia caryophyllata extract and a water-soluble zinc salt are used in combination.

Means for Solving the Problems

[0005] The present inventor earnestly studied to stably blend Eugenia caryophyllata extract and a water-soluble zinc salt. As a result, it was found that the generation of precipitates can be suppressed by blending sodium citrate, citric acid, and a water-soluble zinc salt under specific conditions. If these conditions are not satisfied, there is a risk of precipitation.

Effects of the Invention

[0006] By providing a method that does not generate precipitates even over time, saffron extract and a water-soluble zinc salt can be stably formulated in an external composition.

[0007] This disclosure includes, for example, the subject matter described in the following items. Item 1. An external composition containing saffron extract and a water-soluble zinc salt, further containing citric acids that satisfy the following conditions. Zinc content 0.1% by mass or less Sodium citrate / citric acid (mass ratio) 10 - 189 Citric acid equivalent value 0.4 - 7.2 Citric acid equivalent value / zinc content 7.5 - 112 Item 2. The external composition according to Item 1, wherein the water-soluble zinc salt is zinc gluconate.

Mode for Carrying Out the Invention

[0008] Hereinafter, embodiments according to the present invention will be described.

[0009] The external composition included in this disclosure contains citric acid, sodium citrate, saffron extract, and zinc gluconate. This external composition may be referred to as "the external composition of this disclosure."

[0010] The content of the water-soluble zinc salt in the external composition is not particularly limited, but it is preferable that zinc is contained in the external composition at 0.5 to 0.1% by mass. More preferably, the water-soluble zinc salt is contained at 0.8 to 0.1% by mass.

[0011] It is preferable that citric acid is contained in the external composition at 0.05 to 0.5% by mass. More preferably, citric acid is contained in the external composition at 0.1 to 0.4% by mass.

[0012] Sodium citrate is preferably contained in the external composition in an amount of 0.05 to 0.5% by mass. More preferably, sodium citrate is contained in the external composition in an amount of 0.1 to 0.4% by mass.

[0013] The amount of zinc in the present invention refers to the mass% of zinc element in the external composition. The amount of zinc was calculated assuming that the atomic weight of zinc is 65.39 g / mol and the molecular weight of zinc gluconate is 455.685 g / mol.

[0014] The amount of zinc in the present invention is preferably 0.1% by mass or less in the external composition. More preferably, the amount of zinc is 0.06% by mass or less in the external composition. Even more preferably, the amount of zinc is 0.03% by mass or less in the external composition.

[0015] The citrate conversion value in the present invention is calculated by the following formula. In the present invention, the molecular weights of citric acid and sodium citrate were calculated assuming 192.124 g / mol and 258.06 g / mol, respectively. ([Molecular weight of citric acid] / [Molecular weight of Na citrate]) × [Content mass (%) of Na citrate] + [Content mass (%) of citric acid] Citrates other than sodium citrate, such as potassium citrate, are not preferred.

[0016] The citrate conversion value in the present invention is preferably in the range of 0.4 to 7.2. More preferably, the citrate conversion value in the present invention is in the range of 0.45 to 7.0. Even more preferably, the citrate conversion value in the present invention is in the range of 0.50 to 6.5.

[0017] The “Na citrate / citric acid” in the present invention is calculated by the following formula. [Content mass (%) of Na citrate] / [Content mass (%) of citric acid]

[0018] The value of "sodium citrate / citric acid" in the present invention is preferably in the range of 10 to 189. More preferably, the value of "sodium citrate / citric acid" in the present invention is in the range of 15 to 150.

[0019] Regarding the "citric acid equivalent value / zinc amount" in the present invention, it is calculated by the following formula. [Citric acid equivalent value calculated in <0015>] / [Zinc content mass (%)]

[0020] The value of "citric acid equivalent value / zinc amount" in the present invention is preferably in the range of 7.5 to 112.

[0021] The safflower extract is an extract of safflower, which is the root of safflower, and has effects such as whitening and anti-inflammatory effects. The production method of the safflower extract is not particularly limited, and it can be produced by a known method. Also, the extraction solvent is not particularly limited, and for example, known solvents commonly used in ordinary extraction such as water, alcohol, ether, and chloroform can be used. Further, commercially available products can be used as the safflower extract.

[0022] Although not particularly limited, examples of the form of the skin-external composition of the present invention include ointments, creams, gels, lotions, emulsions, beauty liquids, lotions, face packs, etc., and can be used as cosmetics, quasi-drugs, or pharmaceuticals.

[0023] In the skin-external composition of the present invention, within a range not impairing the effects of the present invention, known optional components that can generally be formulated in skin-external compositions may be further formulated alone or in combination of two or more.

[0024] In the skin care composition of the present invention, in addition to the above components, if necessary, components usually used in skin care compositions of cosmetics and quasi-drugs are appropriately formulated within a range not impairing the effects of the present invention. It is possible. For example, surfactants, polymer compounds, oils and fats, alcohols, moisturizing agents, antioxidants, ultraviolet absorbers, preservatives, chelating agents, amino acids, sugars, vitamins, animal and plant extracts, colorants, inorganic powders and organic powders such as powder agents, pH adjusters such as organic acids and inorganic acids, etc. can be appropriately blended according to the application. Specific examples of the blendable components are listed below.

[0025] The surfactant is not particularly limited, but examples include anionic surfactants; cationic surfactants; amphoteric surfactants such as imidazoline-based amphoteric surfactants and betaine-based surfactants; nonionic surfactants such as sorbitan-based surfactants, glycerin fatty acid esters, polyglycerin fatty acid esters, propylene glycol fatty acid esters, alkyl glycosides, Tween-based surfactants, polyoxyethylene glycerin fatty acid esters, polyoxyethylene polyglycerin fatty acid esters, polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene hydrogenated castor oil derivatives, sucrose fatty acid esters, polyoxyethylene alkyl ethers, Pluronic-type surfactants, and alkanolamides.

[0026] The polymer compound is not particularly limited, but polyethylene glycol with an average molecular weight of about several hundred to 20,000 ; cellulose-based polymers; alginic acid-based polymers; starch-based polymers; acrylic-based polymers; non-natural polymers such as vinyl-based polymers, and natural polymers such as plant-based polymers like carrageenan, pectin, agar, starch, gum arabic, guar gum, and algocolloid, animal-based polymers such as collagen and its derivatives, casein, and gelatin, and microbial-based polymers such as xanthan gum and gellan gum, etc. can be mentioned.

[0027] The fats and oils are not particularly limited, and examples include vegetable oils; animal oils; hydrocarbon oils such as liquid paraffin, squalane, and petrolatum; silicones such as linear polysiloxanes, cyclic polysiloxanes, methyltrimethicone, silicone resins, and modified polysiloxanes; higher fatty acids such as lauric acid, stearic acid, and oleic acid; waxes such as beeswax, lanolin, and its derivatives; monoalkyl fatty acid esters; polyhydric alcohol fatty acid esters; hydrogenated oils, and the like.

[0028] The alcohols include lower alcohols such as ethyl alcohol and butyl alcohol; higher alcohols such as lauryl alcohol, stearyl alcohol, behenyl alcohol, and batyl alcohol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3 - butylene glycol, and glycerin; polyhydric alcohol polymers such as dipropylene glycol, diglycerin, and polyglycerin; sugar alcohols such as sorbitol, maltitol, mannitol, and erythritol; and other alcohols such as lanolin alcohol, cholesterol, and phytosterol, and the like.

[0029] The humectants include polyhydric alcohols such as low - molecular - weight polyethylene glycol, propylene glycol, 1,3 - butylene glycol, and glycerin, chondroitin sulfate, hyaluronic acid, sodium lactate, pyrrolidone carboxylate, collagens, plant extracts, and the like.

Examples

[0030] Test examples and formulation examples are given below to further specifically describe this embodiment, but the present invention is not limited thereto. An external composition of Example 1 was prepared according to the composition and content (mass%) shown in Table 1 below.

[0031] (Stability Evaluation Test) For the external composition of Example 1 shown in Table 1, stability tests were carried out at -5°C, 25°C, and 40°C. Each sample was left at each temperature for 3 months, and those without precipitation were evaluated as ○, those with slight precipitation were evaluated as △, and those with precipitation or other crystals were evaluated as ×.

[0032]

Table 1

[0033] As shown in Table 1, for Example 1, no precipitation was observed even after 3 months at each temperature, and the results of the stability test were good.

Claims

1. An external composition containing propolis extract and a water-soluble zinc salt, further containing citric acids that satisfy the following conditions. Zinc content 0.1% by mass or less Sodium citrate / citric acid (mass ratio) 10 - 189 Citric acid equivalent value 0.4 - 7.2 Citric acid equivalent value / zinc content 7.5 - 112

2. The external composition according to claim 1, wherein the water-soluble zinc salt is zinc gluconate.

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