Oral composition and oral moisturizing agent

Abstract

To provide an oral composition and an oral moisturizing agent, capable of improving the persistence of oral moisturizing action.SOLUTION: The present invention provides an oral composition and an oral moisturizing agent, containing hydroxypropyl chitosan.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition and an oral moisturizer.

Background Art

[0002] Generally, saliva not only aids digestion, but also maintains the humidity in the mouth, prevents the growth of miscellaneous bacteria, and prevents dental caries and bad breath. It is known that xerostomia, or dry mouth, which is caused by stress, side effects of drugs, etc., may develop due to a decrease in the amount of saliva secreted and continuous dryness in the mouth. In particular, the elderly are prone to xerostomia due to a decrease in the amount of saliva secreted due to aging and the effects of various drugs. Xerostomia is known to cause bad breath, inflammation or cracks in the oral and lip mucosa, ulcers in the oral mucosa, periodontal disease, dental diseases such as toothache, etc.

[0003] Conventionally, for example, a composition for improving xerostomia described in Patent Document 1 is known. Patent Document 1 discloses a beverage for improving xerostomia in the elderly, which contains an aqueous solution of hyaluronate at 0.20 to 0.30% (w / v) in a container.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, conventional compositions for xerostomia have a problem that the retention of moisturizing components such as hyaluronic acid is still insufficient in the oral cavity affected by saliva and the like. Therefore, further improvement in the persistence of the moisturizing effect has been demanded.

Means for Solving the Problems

[0006] As a result of research to solve the above problems, the present inventors have newly found that hydroxypropyl chitosan is excellent in the persistence of oral moisturizing action. Each aspect for solving the above problems will be described.

[0007] The oral composition of Aspect 1 is characterized by containing hydroxypropyl chitosan. Aspect 2 is the oral composition according to Aspect 1, wherein the content of the hydroxypropyl chitosan is 0.01% by mass or more and 8% by mass or less.

[0008] Aspect 3 is for oral moisturizing in the oral composition according to Aspect 1 or 2. The oral moisturizer of Aspect 4 is characterized by containing hydroxypropyl chitosan.

Effects of the Invention

[0009] According to the oral composition and the oral moisturizer of the present invention, the persistence of the oral moisturizing action can be improved.

Brief Description of the Drawings

[0010]

Figure 1

Figure 2

Modes for Carrying Out the Invention

[0011] Embodiments embodying the oral composition and the oral moisturizer according to the present invention will be described. Since the oral composition and the oral moisturizer contain the same components, the oral moisturizer will be described below.

[0012] In the present invention, the oral composition is mainly intended for use in the oral cavity. It includes not only oral preparations that are discharged from the oral cavity after use but also edible foods and beverages that can be ingested.

[0013] The oral moisturizer contains hydroxypropyl chitosan. Hereinafter, the components constituting the oral moisturizer will be described. <Hydroxypropyl chitosan> Hydroxypropyl chitosan has a structure of an oxidation propylene adduct of chitosan obtained by deacetylating the polysaccharide chitin.

[0014] The content of hydroxypropyl chitosan in the oral moisturizer is not particularly limited. The content of hydroxypropyl chitosan is, for example, 0.01% by mass or more and 8% by mass or less. When the content of hydroxypropyl chitosan is 8% by mass or less, the stability in the oral moisturizer can be further improved. Also, when the content of hydroxypropyl chitosan is 0.01% by mass or more, the oral moisturizing effect can be further improved. Hereinafter, the content of the above components in the oral moisturizer is expressed by omitting "by mass" as "%". The upper limit value of the content of the above components is preferably 7.5%, more preferably 7%. The lower limit value of the content of each component is preferably 0.05%, more preferably 0.1%. The upper limit value or the lower limit value of the said range may be, for example, 0.01, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, or 8%.

[0015] <Other components> Depending on the purpose of application, form, use, etc., the oral moisturizer may be formulated with other components in addition to the aforementioned components, such as medicinal ingredients, surfactants, abrasives, wetting agents, thickeners, stabilizers, preservatives, sweeteners, pH adjusters, antioxidants, fragrances, colorants, etc. As for these respective components, known ones formulated in the oral moisturizer can be used. These components may be used individually, one kind at a time, or in combination of two or more kinds.

[0016] Examples of medicinal ingredients include bactericides, blood circulation promoters, anti-inflammatory agents, bleeding improvers, tissue repair agents, remineralizing agents, hypersensitivity suppressants, etc. Specific examples of medicinal ingredients include, for example, as bactericides, anionic bactericides such as sodium cocoyl sarcosinate and sorbic acid, cationic bactericides such as chlorhexidine hydrochloride, chlorhexidine gluconate, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, etc., amphoteric bactericides such as dodecyldiaminoethyl glycine, halogenated diphenyl ethers such as triclosan (2’,4,4’-trichloro-2-hydroxy-diphenyl ether), phenolic bactericides such as isopropylmethylphenol, and hinokitiol.

[0017] Examples of blood circulation promoters include vitamin E compounds such as dl-α-tocopherol acetate, tocopherol succinate, tocopherol nicotinate, etc., and enzymes such as dextranase, amylase, protease, mutanase, lysozyme, and lytic enzyme (lytech enzyme).

[0018] Examples of anti-inflammatory agents include epsilon-aminocaproic acid, dipotassium glycyrrhizinate, etc. Examples of bleeding improvers include tranexamic acid, ascorbic acid, etc.

[0019] Examples of tissue repair agents include allantoin, etc. Examples of remineralizing agents include fluorine compounds such as sodium fluoride, etc. Examples of the hypersensitivity inhibitor include nitrates (potassium nitrate), aluminum lactate, hydroxyapatite, tin fluoride, arginine, and the like.

[0020] In addition, examples include plant extracts extracted with water-soluble solvents, chlorophyll, sodium chloride, zinc chloride, potassium nitrate, and the like. Specific examples of the surfactant include, for example, nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

[0021] Specific examples of the nonionic surfactant include, for example, sugar fatty acid esters such as sucrose fatty acid ester and maltose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester, sorbitan fatty acid esters such as sorbitan stearate and sorbitan monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan laurate (also referred to as polysorbate 20), polyoxyethylene sorbitan stearate (also referred to as polysorbate 60), polyoxyethylene sorbitan oleate (also referred to as polysorbate 80), fatty acid alkanolamides such as lauric acid diethanolamide, polyoxyethylene alkyl ethers such as polyoxyethylene stearyl ether and polyoxyethylene oleyl ether, polyethylene glycol fatty acid esters such as polyethylene glycol monooleate and polyethylene glycol monolaurate, alkyl glycosides such as lauryl glycoside and decyl glycoside, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, polyoxyethylene hydrogenated castor oil (with an average addition mole number of ethylene oxide of 10, 20, 40, 60), glycerin fatty acid esters, polyoxyethylene propylene block copolymers, and the like.

[0022] Specific examples of anionic surfactants include, for example, sulfate esters such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate, sulfosuccinates such as sodium lauryl sulfosuccinate and sodium polyoxyethylene lauryl ether sulfosuccinate, acyl amino acid salts such as sodium cocoyl sarcosinate and sodium lauroyl methyl alaninate, and sodium cocoyl methyl taurine.

[0023] Specific examples of cationic surfactants include, for example, quaternary alkyl ammonium salts such as cocoyl arginine ethyl PCA, cetyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, and stearyl trimethyl ammonium chloride, and chlorhexidine gluconate.

[0024] Specific examples of amphoteric surfactants include, for example, amino acid type amphoteric surfactants such as N-lauryl diaminoglycine and N-myristyl diethyl glycine, and betaine type amphoteric surfactants such as alkyl dimethyl amino acetic acid betaine, N-alkyl-N'-carboxymethyl-N'-hydroxyethyl ethylene diamine salt, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, and cocamidopropyl betaine.

[0025] Specific examples of abrasives include calcium carbonate, calcium phosphate, dicalcium phosphate, calcium pyrophosphate, insoluble sodium metaphosphate, titanium oxide, amorphous silica, crystalline silica, abrasive silica, thickening silica, aluminosilicate, aluminum oxide, titanium oxide, aluminum hydroxide, resin, etc. The above silica is also called anhydrous silicic acid.

[0026] Specific examples of wetting agents include, for example, propylene glycol, glycerin, sorbitol, polyethylene glycol, 1,3-butylene glycol, water, alcohol, etc.

[0027] Specific examples of thickeners include, for example, sodium polyacrylate, carrageenan, sodium carboxymethyl cellulose, sodium alginate, xanthan gum, hydroxyethyl cellulose, crystalline cellulose, hydroxypropyl methyl cellulose, methyl cellulose, propylene glycol alginate, etc. Thickeners are also called binders.

[0028] Specific examples of stabilizers include, for example, sodium edetate, sodium thiosulfate, sodium sulfite, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate, etc.

[0029] Specific examples of preservatives include, for example, 1,2-dibromo-2,4-dicyanobutane, photosensitizer, isothiazolone derivatives, hydantoin derivatives, parabens, sodium benzoate, phenol, etc.

[0030] Specific examples of sweeteners include, for example, saccharin, sodium saccharin, acesulfame potassium, stevia extract, palatinose, palatinite, erythritol, maltitol, xylitol, lactitol, etc.

[0031] Specific examples of pH adjusters include, for example, citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or chemically possible salts thereof, sodium hydroxide, etc.

[0032] Specific examples of antioxidants include, for example, tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters, etc. The fragrance may be a natural fragrance or a synthetic fragrance. It may also be a single fragrance or a compound fragrance.

[0033] Specific examples of the fragrance include, for example, l-menthol, d-carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, star anise oil, cinnamon oil, cinnamaldehyde, mint oil, vanillin, and the like.

[0034] Specific examples of the coloring agent include, for example, legal dyes such as Green No. 1, Green No. 3, Blue No. 1, Yellow No. 4, Yellow No. 5, Red No. 102, Red No. 3, sodium copper chlorophyllin, titanium oxide, and the like.

[0035] <Application Forms, Dosage Forms, and Uses of Oral Moisturizers and Oral Compositions> The application forms of the oral moisturizer and the oral composition are not particularly limited, and for example, they can be used as pharmaceuticals, quasi-drugs, cosmetics, foods, and drinks.

[0036] The dosage form of the oral moisturizer is not particularly limited. For example, by containing a solvent such as water or alcohol, it can be applied to ointments, pastes, pastilles, sprays, gels, solutions, suspensions, gums, and the like.

[0037] The type of water used as the solvent is not particularly limited, and for example, distilled water, pure water, ultrapure water, purified water, tap water, and the like can be used. The type of alcohol used as the solvent is not particularly limited, and for example, ethanol can be used. It is also possible to use a mixture of water and alcohol.

[0038] As for the uses of the oral moisturizer and the oral composition, known uses can be appropriately adopted. Specifically, for example, chewing agents, orally dissolving agents, orally disintegrating agents, tongue care agents, oral fresheners, dentifrices, mouthwashes, gargles, liquid dentifrices, biofilm dispersants, halitosis preventives, gum massage agents, oral wetting agents, tongue coating removers, oral coating agents, oral bactericides, throat bactericides, oral and throat agents, periodontal disease therapeutic agents, denture adhesives, denture coating agents, denture stabilizers, denture preservatives, denture cleaners, implant care agents, etc. can be mentioned.

[0039] <Action of this embodiment> The oral moisturizer and the oral composition can improve the persistence of the oral moisturizing action by the above-described components. More specifically, hydroxypropyl chitosan interacts with mucin as a mucoprotein which is one of the salivary components, thereby improving the retention of hydroxypropyl chitosan in the oral cavity. In addition, since hydroxypropyl chitosan itself has excellent water retention ability, it can exhibit excellent moisturizing action in the oral cavity.

[0040] <Effect of this embodiment> The effects of the oral moisturizer or the oral composition of this embodiment will be described. (1) The oral moisturizer or the oral composition of this embodiment is configured to contain hydroxypropyl chitosan. Therefore, the persistence of the oral moisturizing action can be improved.

[0041] (2) With the oral moisturizer or the oral composition of this embodiment, improvement or alleviation of symptoms of xerostomia is expected. Further, along with the improvement of xerostomia, improvement of dental diseases such as halitosis, inflammation or cracks of oral and lip mucosa, ulcers of oral mucosa, periodontal disease, and toothache is expected.

[0042] (3) When the content of hydroxypropyl chitosan is 0.01% by mass or more and 8% by mass or less, the persistence of the oral moisturizing action can be further improved while maintaining the formulation stability of hydroxypropyl chitosan.

[0043] <Another example of this embodiment> Incidentally, the above embodiment can be implemented with the following modifications. The present embodiment and the following modification examples can be implemented in combination with each other within a technically consistent range.

[0044] · It may be applied to pets other than humans, domestic animals such as livestock, etc.

Example

[0045] The oral moisturizer of the present embodiment will be described in more detail based on the following examples. Note that the oral moisturizer is not limited to the configuration described in the example column. <Test Example 1: Evaluation of Oral Moisturizing Property> (A) Retention in the oral cavity by hydroxypropyl chitosan, etc. (1) 20 mg of hydroxyapatite powder was washed with distilled water. (2) An appropriate amount of 1% by mass butamchine aqueous solution was added to the above (1), and removal of the supernatant by shaking and centrifugation was repeated 3 times. (3) An appropriate amount of the material aqueous solution in Table 1 was added to the above (2), and removal of the supernatant by shaking and centrifugation was performed. (4) It was washed with distilled water. (5) Drying was performed, and the mass after drying was measured.

[0046] The results are shown in the "Retention in the oral cavity" column of Table 1. (B) Water retention capacity of hydroxypropyl chitosan, etc. For each material aqueous solution, the ratio of bound water was determined by DSC according to a conventional method. The water retention capacity was evaluated according to the following criteria. The results are shown in the "Water retention capacity" column of Table 1.

[0047] 3: When the ratio of bound water is higher than that of hyaluronic acid 2: When the ratio of bound water is lower than that of hyaluronic acid 1: When there is no ratio of bound water

[0048]

Table 1

[0049] During the above series of treatments, changes in the frequency (f) and changes in the dissipation coefficient (D) were measured in real time. In FIG. 1, the results using the aqueous solution of hydroxypropyl chitosan of Example 8 are shown. In FIG. 2, the results using the aqueous solution of succinyl carboxymethyl chitosan of Comparative Example 2 are shown.

[0050] (Supplementary Note) Next, the technical ideas that can be grasped from the above embodiments and alternative examples are added below. (i) The oral composition used for improving xerostomia.

Claims

1. An oral composition characterized by containing hydroxypropyl chitosan.

2. The oral composition according to Claim 1, wherein the content of the hydroxypropyl chitosan is 0.01% by mass or more and 8% by mass or less.

3. The oral composition according to Claim 1, which is for oral moisturization.

4. An oral moisturizer characterized by containing hydroxypropyl chitosan.

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