Cosmetic and method for producing the same

Abstract

To provide a cosmetic having superior skin compatibility.SOLUTION: One embodiment of a cosmetic according to the present invention comprises: (A) a pyrimidylpyrazole compound or a pharmacologically acceptable salt thereof; (B) a liquid oil component that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters; and (C) a solid oil component that is solid or semi-solid at 25°C and contains at least one selected from the group consisting of glyceryl monoalkyl ethers, higher alcohols having 18 or more carbon atoms, and candelilla wax.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a cosmetic preparation and a method for producing the same. [Background technology]

[0002] Oil-in-water emulsion cosmetics are known in which large oily particles with an average particle size of 50 μm to 10 mm are dispersed in an aqueous phase. Cosmetics containing such large oily particles are not only visually novel and beautiful because the oily particles are dispersed in a size that can be seen with the naked eye, but also provide a fresh and refreshing feel when applied to the skin, which becomes moist over time, providing an unprecedented feeling of use. In addition, if degradable oil-soluble components are held in the large oily particles, the decomposition of the oil-soluble components can be suppressed.

[0003] For example, a capsule-containing cosmetic has been proposed in which oil capsules having an average particle size of 100 μm or more containing an oily component that is solid at room temperature are dispersed in an aqueous medium (see Patent Document 1).

[0004] However, the capsule-containing cosmetic composition described in Patent Document 1 has a problem in that it does not blend satisfactorily with the skin. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2006-104131 A Summary of the Invention [Problem to be solved by the invention]

[0006] In view of the above, an object of one embodiment of the present invention is to provide a cosmetic that is highly compatible with the skin. [Means for solving the problem]

[0007] In order to solve the above problems, one embodiment of the cosmetic according to the present invention is (A) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof,

[0008] [Chemistry] (In the general formula (1), R 1 , R 3 , R 4 , and R 6 each independently represent an alkyl group having 1 to 3 carbon atoms, and R 2 and R 5 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.) (B) a liquid oil component that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, (C) a solid or semi-solid solid oil component that is solid or semi-solid at 25°C and contains at least one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax, and is characterized by containing [Advantages of the Invention]

[0009] According to one embodiment of the present invention, a cosmetic excellent in skin compatibility can be provided. [Embodiments for Carrying Out the Invention]

[0010] Hereinafter, embodiments of the present invention will be described in detail. Note that the embodiments are not limited by the following description and can be appropriately changed without departing from the gist of the present invention. In addition, in this specification, "~" indicating a numerical range means including the numerical values described before and after it as the lower limit value and the upper limit value, unless otherwise specified.

[0011] (Cosmetic) The cosmetic according to one embodiment contains: (A) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof; (B) a liquid oil component that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters; and (C) a solid or semi-solid solid oil component that contains at least one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax, and further contains other components as necessary.

[0012]

Chem.

[0013] The cosmetic according to one embodiment is excellent in skin compatibility. In the cosmetic according to one embodiment, "skin compatibility" means that the cosmetic easily penetrates into the skin. Therefore, it is different from the "moist" feeling of feeling moist after the cosmetic penetrates into the skin.

[0014] The form of the cosmetic according to one embodiment is not particularly limited, but it is preferably an oil-in-water type cosmetic containing oil capsules having a capsule structure in which the outer phase is coated with the solid oil component of component (C) around the inner phase containing the liquid oil component of component (B) in an aqueous solvent. Crystallizing the solid oil component forming the outer phase can also result in an appropriate firmness and a unique feeling of use.

[0015] In the cosmetic according to one embodiment, the aqueous solvent is not particularly limited as long as it does not dissolve the component (B) and the component (C), and examples thereof include water, alcohol, and the like. Specifically, those described in the item of <<aqueous solvent>> described later can be used.

[0016] The average particle diameter of the oil capsules is not particularly limited and can be appropriately selected according to the purpose, but is preferably 100 μm or more, more preferably 100 μm to 1.5 mm, and still more preferably 100 μm to 1 mm. When the average particle diameter of the capsules is 100 μm or more, it is moist when applied to the skin, easily gives a refreshing feeling, and can also give a moist feeling after some time. In addition, it can also give a visual aesthetic to the user. The average particle diameter of the oil capsules can be measured by microscopic observation.

[0017] The content of the oil capsules in the cosmetic according to one embodiment is not particularly limited and can be appropriately selected according to the content of the component (B) and the component (C), etc., but is preferably 0.5% by mass to 10% by mass, more preferably 1% by mass to 5% by mass, and still more preferably 2% by mass to 4% by mass with respect to the total mass of the cosmetic.

[0018] <(A) Pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof> The pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof (hereinafter sometimes referred to as "component (A)") has very low cytotoxicity. In the cosmetic according to one embodiment, the component (A) is contained in the aqueous solvent.

[0019] In the general formula (1), R 1 , R 3 , R 4 , and R 6 each independently represents an alkyl group having 1 to 3 carbon atoms. In one embodiment, R 1 , R 3 , R 4 , and R 6The "alkyl group having 1 to 3 carbon atoms" shown means a linear, branched, or cyclic saturated hydrocarbon group having 1 to 3 carbon atoms. Further, in one embodiment, "each independently" means that R 1 , R 3 , R 4 , and R 6 may each be a different alkyl group having 1 to 3 carbon atoms or the same alkyl group having 1 to 3 carbon atoms.

[0020] Examples of the alkyl group having 1 to 3 carbon atoms represented by R 1 , R 3 , R 4 , and R 6 include, for example, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, a cyclopropyl group, and the like. Among these, as the alkyl group having 1 to 3 carbon atoms represented by R 1 , R 3 , R 4 , and R 6 , a methyl group and an ethyl group are preferable, and a methyl group is more preferable.

[0021] In the general formula (1), R 2 and R 5 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. In one embodiment, the "alkyl group having 1 to 3 carbon atoms" represented by R 2 and R 5 means a linear, branched, or cyclic saturated hydrocarbon group having 1 to 3 carbon atoms. Further, in one embodiment, "each independently" means that R 2 and R 5 may each be a different hydrogen atom or alkyl group having 1 to 3 carbon atoms or the same hydrogen atom or alkyl group having 1 to 3 carbon atoms.

[0022] Examples of the alkyl group having 1 to 3 carbon atoms represented by R 2 and R 5 include, for example, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, a cyclopropyl group, and the like. As R 2 and R 5 , a hydrogen atom is preferable.

[0023] Examples of pharmacologically acceptable salts of the pyrimidylpyrazole compound represented by the general formula (1) include inorganic acid salts such as hydrochloride, hydrobromide, sulfate, and phosphate; and organic acid salts such as acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, succinate, tartrate, and methanesulfonate.

[0024] As the pyrimidylpyrazole compound represented by the general formula (1), those appropriately synthesized by known methods may be used, or commercially available products may be used.

[0025] Typical synthesis examples of the pyrimidylpyrazole compound represented by the general formula (1) will be described below, but are not limited thereto. Examples of the synthesis method of the pyrimidylpyrazole compound represented by the general formula (1) include a method of synthesizing by the reaction shown in the following Scheme 1. The reaction shown in the following Scheme 1 can be carried out, for example, according to the methods described in JP-A-62-000404, Dharmpal S Dodd et al., Tetrahedron Letters, Volume 45, Issue 22, 2004, p.4265-4267, Gazzetta Chemica Italiana, Vol. 93, Parte I, 1963, p. 100, etc.

[0026]

Chemical formula

[0027] In Scheme 1, the reaction between the hydrazine compound represented by the general formula (2) and the 1,3-dicarbonyl compound represented by the general formula (3a) or the 1-sulfonyl-3-carbonyl compound represented by the general formula (3b) can be carried out, for example, in a suitable solvent such as methanol under an acid catalyst such as hydrochloric acid or acetic acid, with heating if necessary.

[0028] The pharmacologically acceptable salts of the pyrimidylpyrazole compounds represented by the general formula (1) may be those appropriately synthesized by known methods or commercially available products. Examples of the synthesis of the pharmacologically acceptable salts of the pyrimidylpyrazole compounds represented by the general formula (1) include methods of converting the pyrimidylpyrazole compounds represented by the general formula (1) into acid addition salts appropriately selected from known methods. Examples of the acids used in the method of converting into acid addition salts include inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, and phosphoric acid; and organic acids such as acetic acid, propionic acid, citric acid, lactic acid, oxalic acid, maleic acid, fumaric acid, succinic acid, tartaric acid, and methanesulfonic acid.

[0029] The hydrazine compounds represented by the general formula (2) used as starting materials in Scheme 1 may be those appropriately synthesized by known methods or commercially available products. Examples of the synthesis of the hydrazine compounds represented by the general formula (2) include methods of synthesizing by the reactions shown in Scheme 2 below. The reactions shown in Scheme 2 below can be carried out, for example, according to the methods described in JP-A-8-208620.

[0030]

Chemical formula

[0031] In addition, the hydrazine compound represented by the general formula (2) used as the starting material in Scheme 1 can also be synthesized from the pyrimidine compound represented by the general formula (5) having a leaving group Z by the reaction shown in the following Scheme 3. Examples of the leaving group Z in the pyrimidine compound represented by the general formula (5) include halogen. The reaction shown in the following Scheme 3 can be carried out, for example, according to the methods described in Takeo Naito et al., Chemical and Pharmaceutical Bulletin, 1969, Vol. 17, No. 7, pp. 1467-1478; Kaname Takagi et al., Chemical and Pharmaceutical Bulletin, 1963, Vol. 11, No. 11, pp. 1382-1388; Kenzo Shirakawa, Yakugaku Zasshi, 1953, Vol. 73, No. 6, pp. 635-639, etc.

[0032]

Chemical formula

[0033] Regarding the other compounds used in the reactions of Schemes 1 to 3, those appropriately synthesized by known methods may be used, or commercially available products may be used.

[0034] In the reactions of Schemes 1 to 3, when a functional group is present in the molecule and this functional group may interfere with the reaction or there is a risk of such interference, it is preferable to use an appropriate protecting group to efficiently proceed the reaction. The use of the protecting group can be carried out, for example, according to the methods described in Theodora W. Greene, Peter G. M. Wuts' GREENE'S PROTECTIVE GROUPS IN ORGANIC SYNTHESIS, etc.

[0035] In the reactions of Schemes 1 to 3, when isomers such as conformational isomers, geometric isomers, and optical isomers are present, by appropriately selecting raw materials and reaction conditions and performing separation operations, they can be obtained as pure isomers or geometric isomers. The pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof includes pure isomers or mixtures thereof.

[0036] Examples of the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof include R 1 R 3 R 4 and R 6 being methyl groups, and R 2 and R 5 being hydrogen atoms, and 2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride (also referred to as "dimethylpyrazolyl dimethylpyrimidine hydrochloride") is particularly preferred.

[0037] In the cosmetic according to one embodiment, the content of the component (A) is not particularly limited and can be appropriately selected according to the purpose. However, with respect to the total mass of the cosmetic, 0.1% by mass to 1.5% by mass is preferred, 0.1% by mass to 1% by mass is more preferred, 0.1% by mass to 0.5% by mass is still more preferred, and 0.3% by mass to 0.5% by mass is particularly preferred. When the content of the component (A) is 0.1% by mass or more, the skin compatibility can be improved. Also, even if the component (A) is blended in excess, a remarkable effect commensurate with the increase in amount may not be obtained, and it may affect formulation design and usability, etc., so it is preferably 1.5% by mass or less.

[0038] <(B) Liquid oil component that is liquid at 25°C> The liquid oil component that is liquid at 25°C (hereinafter sometimes referred to as the "component (B)") contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, and further contains other liquid oil components as necessary.

[0039] <<Silicone oil>> In addition to improving skin compatibility, silicone oil can impart a moist and smooth feeling to the skin.

[0040] There are no particular restrictions on the silicone oil, and it can be appropriately selected according to the purpose. Examples include linear silicone, cyclic silicone, modified silicone oil, and the like.

[0041] Examples of linear silicone include dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane (phenylmethylcon), methylhydrogenpolysiloxane, and the like.

[0042] Examples of cyclic silicone include octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and the like.

[0043] Examples of modified silicone oil include amino-modified silicone oil, polyether-modified silicone oil, carboxy-modified silicone oil, alkyl-modified silicone oil, ammonium salt-modified silicone oil, fluorine-modified silicone oil, and the like.

[0044] These silicone oils may be used alone or in combination of two or more. Among these, the silicone oil preferably contains dimethylpolysiloxane (dimethicone).

[0045] The silicone oil may be appropriately synthesized by a known method or a commercially available product may be used.

[0046] <<Polyhydric Alcohol Fatty Acid Ester>> In addition to improving skin compatibility, the polyhydric alcohol fatty acid ester can impart a moist feeling to the skin. The polyhydric alcohol fatty acid ester has a structure in which a polyhydric alcohol and a fatty acid are ester-bonded.

[0047] As the polyhydric alcohol constituting the polyhydric alcohol fatty acid ester, there is no particular limitation as long as it is a dihydric or higher alcohol, and dihydric to hexahydric alcohols are preferred, and dihydric to tetrahydric alcohols are more preferred.

[0048] Specific examples of the polyhydric alcohol constituting the polyhydric alcohol fatty acid ester include ethanol, cetanol, glycerin, polyglycerin, erythritol, hexyl alcohol, isopropanol, 2-octyldodecyl alcohol, octyl alcohol, isocetyl alcohol, isodecyl alcohol, isostearyl alcohol, sorbitan, sorbitol, sucrose, ethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, glucose, decyl alcohol, caprylyl alcohol, octanol, and the like.

[0049] There is no particular limitation on the fatty acid in the polyhydric alcohol fatty acid ester, and it can be appropriately selected according to the purpose. However, saturated or unsaturated fatty acids having 6 to 22 carbon atoms are preferred, saturated or unsaturated fatty acids having 6 to 18 carbon atoms are more preferred, saturated or unsaturated fatty acids having 6 to 14 carbon atoms are still more preferred, and saturated or unsaturated fatty acids having 6 to 12 carbon atoms are particularly preferred.

[0050] There is no particular limitation on the number of ester bonds in the polyhydric alcohol fatty acid ester, and it can be appropriately selected according to the purpose. However, 1 to 6 is preferred, 3 to 5 is more preferred, and 4 to 5 is still more preferred.

[0051] The polyhydric alcohol fatty acid ester is not particularly limited and can be appropriately selected according to the purpose. For example, octanoic acid esters such as cetyl octanoate; isooctanoic acid esters such as glyceryl tri-2-ethylhexanoate and pentaerythrityl tetraethylhexanoate; lauric acid esters such as hexyl laurate; myristic acid esters such as isopropyl myristate and octyldodecyl myristate; palmitic acid esters such as octyl palmitate; stearic acid esters such as isocetyl stearate; isostearic acid esters such as isopropyl isostearate; isopalmitic acid esters such as octyl isopalmitate; oleic acid esters such as isodecyl oleate; adipic acid diesters such as diisopropyl adipate; sebacic acid diesters such as diethyl sebacate; malic acid diisostearyl such as diisostearyl malate and the like. These may be used alone or in combination of two or more. Among these, polar oil components are preferred, isooctanoic acid esters are more preferred, and pentaerythrityl tetraethylhexanoate is even more preferred.

[0052] The polyhydric alcohol fatty acid ester may be appropriately synthesized by a known method or a commercially available product may be used.

[0053] In the cosmetic according to one embodiment, the content of at least any one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid ester is not particularly limited and can be appropriately selected according to the purpose. However, with respect to the total content of component (B), 0.01% by mass to 100% by mass is preferred, 50% by mass to 100% by mass is more preferred, 80% by mass to 100% by mass is even more preferred, and 90% by mass to 100% by mass is particularly preferred.

[0054] <<Other liquid oil components>> In the cosmetic according to one embodiment, component (B) may contain a liquid oil component (sometimes referred to as "other liquid oil components") that is liquid at 25°C, other than at least any one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid ester.

[0055] As other liquid oils, there is no particular limitation as long as the effects of the cosmetic according to one embodiment are not impaired, and they can be appropriately selected according to the purpose. For example, oils and fats, hydrocarbon oils, etc. may be mentioned. These may be used alone or in combination of two or more.

[0056] Examples of oils and fats include vegetable oils and fats such as avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, sesame oil, peony oil, southern magnolia oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese cedar oil, jojoba oil, germ oil, cocoa butter, coconut oil, hydrogenated coconut oil, palm oil, palm kernel oil, candlenut oil, cinnamon oil, grape oil, almond oil, sunflower oil, wheat germ oil, rice germ oil, evening primrose oil, etc.; animal oils and fats such as egg yolk oil, horse fat, beef tallow, mutton fat, hydrogenated beef tallow, lard, beef bone fat, beef foot fat, etc.

[0057] Examples of hydrocarbon oils include linear, branched, or volatile hydrocarbon oils. Specific examples of hydrocarbon oils include liquid paraffin, squalane, squalene, pristane, isoparaffin, α-olefin oligomer, hydrogenated polydecene, etc. May be used.

[0058] In the cosmetic according to one embodiment, the content of other liquid oils with respect to the total content of component (B) has no particular limitation as long as the effects of the cosmetic according to one embodiment are not impaired, and it can be appropriately selected according to the content of at least any one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid ester.

[0059] In the cosmetic according to one embodiment, the content of component (B) is not particularly limited and can be appropriately selected according to the purpose. However, based on the total mass of the cosmetic, 0.01% by mass to 10% by mass is preferable, 0.1% by mass to 5% by mass is more preferable, and 1% by mass to 3% by mass is even more preferable. When the content of component (B) is 0.01% by mass to 10% by mass, usability such as skin compatibility can be improved.

[0060] In the cosmetic according to one embodiment, the content of component (B) relative to the total content [(B)+(C)] of component (B) and component (C) described later is not particularly limited and can be appropriately selected according to the purpose. However, 50% by mass to 95% by mass is preferable, 60% by mass to 90% by mass is more preferable, and 80% by mass to 90% by mass is even more preferable. When the content of component (B) relative to the total content [(B)+(C)] is 50% by mass to 95% by mass, the stability of the oil capsules can be improved, and the oil capsules can be given appropriate firmness, and usability such as skin compatibility can be improved.

[0061] <(C) Solid or semi-solid solid oil at 25°C> The solid or semi-solid solid oil at 25°C (hereinafter sometimes referred to as "component (C)") contains at least one selected from the group consisting of glyceryl monoalkyl ether (batyl alcohol), higher alcohols having 18 or more carbon atoms, and candelilla wax, and may further contain other solid oil components as necessary.

[0062] In the cosmetic according to one embodiment, component (C) preferably acts as an amphiphilic substance. In the cosmetic according to one embodiment, the "amphiphilic substance" is a molecule having both a hydrophobic moiety (lipophilic group) and a hydrophilic moiety (hydrophilic group) in the molecule. Therefore, in water, the hydrophobic moieties of component (C) aggregate due to the hydrophobic effect, forming micelles, which are spherical aggregates with the hydrophilic groups on the outer side in contact with water and the lipophilic groups on the inner side. At this time, component (B) can be incorporated into the inner side having a lipophilic group to form oil capsules.

[0063] In the production of a cosmetic according to an embodiment, the method for forming an oil capsule is not particularly limited and can be appropriately selected according to the purpose. For example, the following methods can be mentioned. First, the component (C), the components (A) and (B), and other components as required are mixed and dissolved together to form liquid oil particles in an aqueous solvent. Then, it is cooled to precipitate only the component (C) to form a film embedding the component (B), thereby forming an oil capsule. In order to form an oil capsule in this way, under the temperature conditions in the mixing and dissolving stage of the component (A), the component (B), the component (C), and other components as required, which are the constituent components of the cosmetic, and the aqueous solvent, the component (C) needs to be liquid, and under the temperature conditions after cooling, it needs to become solid. Note that the temperature conditions after cooling are normal temperature because they include the temperature in the usage environment of the cosmetic according to an embodiment.

[0064] Therefore, the melting point of the component (C) is not particularly limited, but is preferably 45°C or higher and 85°C or lower, more preferably 50°C or higher and 85°C or lower, still more preferably 55°C or higher and 85°C or lower, and particularly preferably 65°C or higher and 85°C or lower. When the melting point of the component (C) is 45°C or higher, the film is less likely to melt in the usage environment of the cosmetic according to an embodiment and has excellent stability at high temperatures. Also, when the melting point of the component (C) is 85°C or lower, the formability and dispersibility of the oil capsule are good.

[0065] <<Glyceryl monoalkyl ether>> Glyceryl monoalkyl ether has a structure in which glycerin and an alkyl are ether-bonded.

[0066] The alkyl constituting the glyceryl monoalkyl ether is not particularly limited and can be appropriately selected according to the purpose. However, a linear or branched alkyl having 16 or more carbon atoms is preferred, a linear or branched alkyl having 16 to 24 carbon atoms is more preferred, and a linear or branched alkyl having 18 to 22 carbon atoms is still more preferred.

[0067] Specific examples of glyceryl monoalkyl ethers include glyceryl monostearyl ether (batyl alcohol) (melting point: 70 °C), glyceryl monocetyl ether (chimyl alcohol) (melting point: 58 °C to 68 °C), and the like.

[0068] For glyceryl monoalkyl ethers, those appropriately synthesized by known methods may be used, or commercially available products may be used.

[0069] <<Higher alcohols having 18 or more carbon atoms>> Higher alcohols having 18 or more carbon atoms may be linear or branched. Specific examples of higher alcohols having 18 or more carbon atoms include behenyl alcohol (melting point: 68 °C), stearyl alcohol (melting point: 52 °C to 62 °C), and the like. These may be used alone or in combination of two or more. Among these, behenyl alcohol is preferred as the higher alcohol having 18 or more carbon atoms.

[0070] For higher alcohols having 18 or more carbon atoms, those appropriately synthesized by known methods may be used, or commercially available products may be used.

[0071] <<Candelilla wax>> The melting point of candelilla wax is 71 °C. For candelilla wax, those appropriately synthesized by known methods may be used, or commercially available products may be used.

[0072] In addition, in the cosmetic according to one embodiment, there are no particular restrictions on the content of at least any one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax, and it can be appropriately selected according to the purpose. However, with respect to the total content of component (C), 0.1% by mass to 100% by mass is preferable, 0.5% by mass to 100% by mass is more preferable, 50% by mass to 100% by mass is more preferable, 80% by mass to 100% by mass is still more preferable, and 90% by mass to 100% by mass is particularly preferable. When the content of at least any one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax is 0.1% by mass or more with respect to the total content of component (C), the average particle diameter of the oil capsules can be set within a suitable range, and the variation in the size of the oil capsules is less likely to occur.

[0073] <<Other solid oil components>> In the cosmetic according to one embodiment, component (C) may contain a solid or semi-solid oil component (which may be referred to as "other solid oil components") that is solid at 25°C, other than at least any one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax.

[0074] There are no particular restrictions on the other solid oil components as long as the effects of the cosmetic according to one embodiment are not impaired, and they can be appropriately selected according to the purpose. For example, hydrocarbon oils, higher alcohols having less than 18 carbon atoms, higher fatty acids, waxes, glycerin fatty acid esters, ester oils, fats and oils, fatty acid monocarboxylic acid lanolin alcohol esters, etc. can be mentioned. These may be used alone or in combination of two or more.

[0075] Examples of the hydrocarbon oil include linear, branched, or volatile hydrocarbon oils. Specific examples of the hydrocarbon oil include ozokerite, solid paraffin, ceresin, beeswax, carnauba wax, polyethylene wax, silicone wax, polyisobutene, microcrystalline wax, petrolatum, etc.

[0076] Examples of higher alcohols having less than 18 carbon atoms include higher alcohols having 6 or more and less than 18 carbon atoms, such as lauryl alcohol, myristyl alcohol, cetyl alcohol, hexyl decanol, and the like.

[0077] Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, lanolin fatty acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid, 12-hydroxystearic acid, and the like.

[0078] Examples of waxes include hydrogenated jojoba oil, cocoa butter, candelilla wax, beeswax, jojoba wax, candelilla wax, cotton wax, carnauba wax, bayberry wax, spermaceti wax, whale wax, montan wax, rice bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, and the like.

[0079] Examples of glycerin fatty acid esters include glyceryl (behenate / eicosandioate) and the like.

[0080] Examples of ester oils include myristyl myristate.

[0081] Examples of fats and oils include hydrogenated castor oil, hardened oil, hydrogenated palm oil, palm oil, hydrogenated coconut oil, and various hydrogenated animal and vegetable fats and oils.

[0082] In the cosmetic according to one embodiment, the content of other solid oil components with respect to the total content of the component (C) is not particularly limited as long as the effects of the cosmetic according to one embodiment are not impaired, and can be appropriately selected according to the content of at least any one selected from the group consisting of glyceryl monoalkyl ether, higher alcohols having 18 or more carbon atoms, and candelilla wax.

[0083] In the cosmetic according to one embodiment, the content of component (C) is not particularly limited and can be appropriately selected according to the purpose. However, based on the total mass of the cosmetic, 0.01% by mass to 10% by mass is preferable, 0.01% by mass to 5% by mass is more preferable, and 0.1% by mass to 1% by mass is even more preferable. When the content of component (C) is 0.01% by mass to 10% by mass, usability such as skin compatibility can be improved.

[0084] In the cosmetic according to one embodiment, the content of component (C) relative to the total content [(B)+(C)] of components (B) and (C) is not particularly limited and can be appropriately selected according to the purpose. However, 5% by mass to 50% by mass is preferable, 5% by mass to 40% by mass is more preferable, 10% by mass to 30% by mass is even more preferable, and 10% by mass to 20% by mass is particularly preferable. When the content of component (C) relative to the total content [(B)+(C)] is 5% by mass or more, it is likely to function as a film-forming material for the oil capsules and can improve the stability of the oil capsules. Also, when the content of component (C) relative to the total content [(B)+(C)] is 50% by mass or less, the oil capsules can have appropriate firmness and usability such as skin compatibility can be improved.

[0085] In the cosmetic according to one embodiment, the total content [(B)+(C)] of components (B) and (C) is not particularly limited and can be appropriately selected according to the purpose. However, based on the total mass of the cosmetic, 0.5% by mass to 10% by mass is preferable, 1% by mass to 5% by mass is more preferable, and 2% by mass to 4% by mass is even more preferable.

[0086] <Other components> The cosmetic according to one embodiment may contain components other than the (A) component, the (B) component, and the (C) component. There are no particular restrictions on the other components, and they can be appropriately selected from known components used in cosmetics. For example, aqueous solvents, water-soluble polymers, oil-soluble thickeners, glycols, glycerins, sugar alcohols, sugars, powders, pigments, dyes, pH adjusters, surfactants other than the (C) component, powder components, fragrances, drugs other than the (A) component, etc. may be mentioned. These may be used alone or in combination of two or more.

[0087] Regarding the content of other components in the cosmetic according to one embodiment, there are no particular restrictions as long as the effects of the cosmetic according to one embodiment are not impaired, and they can be appropriately selected according to the purpose.

[0088] <<Aqueous Solvent>> Examples of the aqueous solvent include water, lower alcohols, etc. Examples of the lower alcohol include alcohols having 5 or less carbon atoms. Specific examples of the lower alcohol include methanol, ethanol, propyl alcohol, isopropyl alcohol, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, etc. These may be used alone or in combination of two or more.

[0089] <<Water-Soluble Polymer>> When the cosmetic according to one embodiment contains a water-soluble polymer, it is preferable in that it acts as a water-soluble thickener capable of thickening the aqueous solvent and can make the stability of the oil capsules better.

[0090] There are no particular restrictions on the water-soluble polymer, and it can be appropriately selected according to the purpose. For example, plant-based polymers, animal-based polymers, microbial-based polymers, starch-based polymers, cellulose-based polymers, alginic acid-based polymers, vinyl-based polymers, acrylic-based polymers, inorganic water-soluble polymers, polyoxyethylene-based polymers, polyoxyethylene polyoxypropylene copolymer-based polymers, etc. may be mentioned. These may be used alone or in combination of two or more.

[0091] Examples of plant-based polymers include gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, gellan gum, carrageenan, pectin, agar, quince seed (marmelo), algal colloid (brown seaweed extract), and the like.

[0092] Examples of animal-based polymers include collagen, casein, albumin, gelatin, and the like.

[0093] Examples of microbial-based polymers include xanthan gum, dextran, succinoglucan, pullulan, and the like.

[0094] Examples of starch-based polymers include plant starches such as corn, wheat, potato, and rice; carboxymethyl starch; methyl hydroxypropyl starch, and the like.

[0095] Examples of cellulose-based polymers include methyl cellulose, nitrocellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, and the like.

[0096] Examples of alginic acid-based polymers include sodium alginate, propylene glycol alginate ester, and the like.

[0097] Examples of vinyl-based polymers include polyvinyl alcohol, polyvinyl acetate, polyvinyl methyl ether, polyvinyl pyrrolidone, vinyl pyrrolidone and vinyl acetate copolymer, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, and the like.

[0098] Examples of acrylic polymers include sodium polyacrylate, polyethyl acrylate, polyacrylic acid alkanolamine, a copolymer of alkyl methacrylate and dimethylaminoethyl methacrylate, poly 2 - acrylamido - 2 - methylpropanesulfonic acid, polymethacryloyloxytrimethylammonium, and the like.

[0099] Examples of inorganic water - soluble polymers include polyethyleneimine, cationic polymers, bentonite, magnesium aluminum silicate, laponite, hectorite, and silicic anhydride.

[0100] These water - soluble polymers may be used alone or in combination of two or more. Among these, alkyl - modified carboxyvinyl polymer has a surfactant action and can also serve to prevent the aggregation and unification of oil - based capsules, so it can be particularly preferably selected as a water - soluble polymer. Examples of alkyl - modified carboxyvinyl polymers include copolymers of acrylic acid and alkyl (meth) acrylate. The number of carbon atoms of the alkyl group in the acrylic acid - alkyl (meth) acrylate copolymer is not particularly limited, but is preferably 10 - 30. In the cosmetic according to one embodiment, "(meth) acrylic acid" means at least any one selected from the group consisting of acrylic acid and methacrylic acid.

[0101] The water - soluble polymer may be appropriately synthesized by a known method or a commercially available product may be used. Examples of commercially available water - soluble polymers include CARBOPOL® 1342 ((acrylic acid - alkyl methacrylate (C10 - C30)) cross - polymer), PEMULENTR® TR - 1 Polymeric Emulsifier ((acrylic acid - alkyl methacrylate (C10 - C30)) cross - polymer), PEMULENTR® TR - 2 Polymeric Emulsifier ((acrylic acid - alkyl methacrylate (C10 - C30)) cross - polymer) (all manufactured by Lubrizol). The number in parentheses after "C" indicates the number of carbon atoms of the alkyl group.

[0102] As for the content of the water-soluble polymer, there is no particular limitation as long as the effects of the cosmetic according to one embodiment are not impaired, and it can be appropriately selected according to the type of the water-soluble polymer, the degree of thickening intended, etc. When an alkyl-modified carboxyvinyl polymer is selected as the water-soluble polymer, 0.001% by mass to 1.0% by mass is preferable, and 0.01% by mass to 0.5% by mass is more preferable, based on the total mass of the aqueous solvent.

[0103] <<Oil-soluble thickener>> Examples of the oil-soluble thickener include condensates of dibenzylidene sorbitol, tribenzylidene sorbitol, dibenzylidene xylitol, benzaldehydes, etc. with pentavalent or higher alcohols; metal soaps such as calcium stearate, calcium palmitate, lithium 2-ethylhexanoate, aluminum 12-hydroxystearate; amides and esters of N-acyl amino acids such as dibutylamide lauroylglutamate, stearylamide lauroylglutamate, laurylamine salt dica-proyl lysine, lauryl ester dica-proyl lysine, lauroylphenylalanine laurylamide dica-proyl lysine; derivatives such as amine salts; dextrin fatty acid esters; 12-hydroxystearic acid, etc. These may be used alone or in combination of two or more.

[0104] <<Glycols>> Examples of the glycols include propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, etc. These may be used alone or in combination of two or more.

[0105] <<Glycerins>> Examples of the glycerins include glycerin, diglycerin, polyglycerin, etc. These may be used alone or in combination of two or more.

[0106] <<Sugar alcohols>> Examples of sugar alcohols include sorbitol, mannitol, maltitol, xylitol, erythritol, etc. These may be used alone or in combination of two or more.

[0107] <<Sugars>> Examples of sugars include fructose, glucose, galactose, maltose, lactose, trehalose, etc. These may be used alone or in combination of two or more.

[0108] <<Powder ingredients>> The powder component may be an inorganic powder or an organic powder, which may be used alone or in combination of two or more kinds.

[0109] Examples of inorganic powders include mica, talc, kaolin, sericite (sericite), muscovite, phlogopite, synthetic mica, red mica, biotite, lithia mica, synthetic mica, anhydrous silicic acid (silica), aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, aluminum oxide, barium sulfate, zeolite, titanium oxide, zinc oxide, and boron nitride.

[0110] Examples of the organic powder include polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, calcium carbonate powder, magnesium carbonate powder, and styrene-acrylic acid copolymer resin powder.

[0111] <<Pigments>> Examples of pigments include inorganic pigments, organic pigments, pearl pigments, metal powder pigments, etc. These may be used alone or in combination of two or more kinds.

[0112] Examples of inorganic pigments include inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide); inorganic yellow pigments such as yellow iron oxide and loess; inorganic black pigments such as black iron oxide and carbon black; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; and inorganic blue pigments such as ultramarine and navy blue.

[0113] Examples of organic pigments include Pigment Red 3, Pigment Red 104, Pigment Red 106, Pigment Red 201, Pigment Red 202, Pigment Red 204, Pigment Red 205, Pigment Red 220, Pigment Red 226, Pigment Red 227, Pigment Red 228, Pigment Red 230, Pigment Red 401, Pigment Red 405, Pigment Red 505, Pigment Orange 203, Pigment Orange 204, Pigment Orange 205, Pigment Yellow 4, Pigment Yellow 5, Pigment Yellow 202, Pigment Yellow 203, Pigment Yellow 205, Pigment Yellow 401, Pigment Blue 1, Pigment Blue 404, Pigment Green 3, and zirconium lakes, barium lakes, or aluminum lakes of these pigments.

[0114] Examples of pearl pigments include titanium dioxide-coated mica, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil.

[0115] Examples of metal powder pigments include aluminum powder and copper powder.

[0116] <<Dye>> Examples of dyes include natural dyes such as chlorophyll and β-carotene. These may be used alone or in combination of two or more.

[0117] <<pH Adjusting Agent>> Examples of pH adjusting agents include potassium hydroxide, sodium hydroxide, triethanolamine, sodium carbonate, lactic acid, citric acid, sodium citrate, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogen carbonate, and ammonium hydrogen carbonate. These may be used alone or in combination of two or more.

[0118] <<Surfactant Other than Component (C)>> Examples of surfactants include anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, etc. These may be used alone or in combination of two or more.

[0119] Examples of anionic surfactants include, for example, fatty acid soaps such as soap bases, sodium laurate, and sodium palmitate; higher alkyl sulfate esters such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfate esters such as triethanolamine polyoxyethylene (hereinafter sometimes abbreviated as "POE") lauryl sulfate and sodium POE lauryl sulfate; N-acyl sarcosinic acids such as sodium lauroyl sarcosinate; higher fatty acid amide sulfonic acids such as sodium N-myristoyl-N-methyl taurate and sodium coconut fatty acid methyl tauride; phosphate esters such as POE stearyl ether phosphate; sulfosuccinates such as sodium monolauroyl monoethanolamide POE sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium linear dodecylbenzene sulfonate and triethanolamine linear dodecylbenzene sulfonate; N-acyl glutamates such as disodium N-stearoyl glutamate and monosodium N-stearoyl glutamate; higher fatty acid ester sulfate esters such as sodium hydrogenated coconut oil fatty acid glycerol sulfate; sulfated oils such as rape oil; POE alkyl ether carboxylic acids; POE alkyl allyl ether carboxylates; higher fatty acid ester sulfonates; secondary alcohol sulfate esters; higher fatty acid alkanolamide sulfate esters; sodium lauroyl monoethanolamide succinate; sodium caseinate, etc.

[0120] Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; alkylpyridinium salts such as cetylpyridinium chloride; alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride, and the like.

[0121] Examples of nonionic surfactants include lipophilic nonionic surfactants other than component (C), hydrophilic nonionic surfactants, etc. Examples of lipophilic nonionic surfactants other than component (C) include sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, and sorbitan trioleate; glycerin polyglycerin fatty acids such as monoricinoleic acid glycerin, sesqui-oleic acid glycerin, and monostearic acid glycerin malate; propylene glycol fatty acid esters such as propylene glycol monostearate; glycerin alkyl ethers; POE·methyl polysiloxane copolymers, etc. Examples of hydrophilic nonionic surfactants include POE sorbitan fatty acid esters such as POE sorbitan monooleate and POE sorbitan monostearate; POE sorbit fatty acid esters such as POE sorbit monolaurate, POE sorbit monooleate, and POE sorbit monostearate; POE glycerin fatty acid esters such as POE glycerin monooleate and POE glycerin distearate; POE fatty acid esters such as POE monooleate, POE distearate, and POE monodioleate; POE alkyl ethers such as POE lauryl ether, POE oleyl ether, and POE cholestanol ester; POE alkyl phenyl ethers such as POE octyl phenyl ether and POE nonyl phenyl ether; POE·polyoxypropylene (hereinafter sometimes abbreviated as "POP") alkyl ethers such as POE·POP monobutyl ether, POE·POP cetyl ether, and POE·POP glycerin ether; POE honey·lanolin derivatives such as POE sorbit beeswax; alkanolamides such as coconut fatty acid diethanolamide and fatty acid isopropanolamide; POE propylene glycol fatty acid ester; POE fatty acid amide, POE alkylamine; sucrose fatty acid ester, alkyl ethoxydimethylamine oxide, etc.

[0122] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants such as 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt; betaine-based surfactants such as amide betaine and sulfobetaine.

[0123] <<Fragrance>> The fragrance may be a natural fragrance or a synthetic fragrance. These may be used alone or in combination of two or more.

[0124] Natural fragrances are fragrances mainly composed of components derived from plants or animals. Examples of natural fragrances include natural plant-derived fragrances such as rose oil, jasmine oil, neroli oil, lavender oil, ylang-ylang oil, tuberose oil, clary sage oil, clove oil, peppermint oil, geranium oil, patchouli oil, sandalwood oil, cinnamon oil, coriander oil, nutmeg oil, pepper oil, lemon oil, orange oil, bergamot oil, opoponax oil, vetiver oil, orris oil, oakmoss oil; natural animal-derived fragrances such as musk oil, civet oil, castoreum oil, ambergris oil.

[0125] Synthetic fragrances can be classified into hydrocarbons, alcohols, aldehydes, ketones, esters, lactones, phenols, acetals, etc. from the perspective of their chemical structure or fragrance groups. Specific examples of synthetic fragrances include hydrocarbons such as limonene and β-caryophyllene; alcohols such as cis-3-hexenol, linalool, farnesol, β-phenylethyl alcohol, geraniol, citronellol, terpineol, menthol, santalol, bagdanol, and bramanol; aldehydes such as 2,6-nonadienal, citral, α-hexylcinnamic aldehyde, l-carvone, cyclopentadecanone, lilial, and lyral; ketones such as β-ionone, damascone, methyl ionone, iron, iso-E-super, acetyl cedrene, and muscone; esters such as linalyl acetate, benzyl benzoate, benzyl acetate, methyl dihydroxyjasmonate, and methyl jasmonate; lactones such as γ-undecalactone, jasmine lactone, cyclopentadecanolide, and ethylene brassylate; phenols such as eugenol; acetals such as phenylacetaldehyde dimethyl acetal; rose oxide, indole, and aurantiol, etc.

[0126] <<Drugs other than component (A)>> Examples of drugs other than component (A) include, for example, vitamins, ultraviolet absorbers, chelating agents, preservatives, plant extracts, moisturizing agents, anti-inflammatory agents, whitening agents, cooling agents, amino acids, antioxidants, bactericides, etc. These may be used alone or in combination of two or more.

[0127] - Vitamins - There are no particular restrictions on vitamins, but fat-soluble vitamins are preferred. Examples of fat-soluble vitamins include vitamin E, retinoids, and fat-soluble derivatives of ascorbic acid, etc.

[0128] Examples of vitamin E include compound groups consisting of tocopherol and its derivatives, compound groups consisting of tocotrienol and its derivatives, etc.

[0129] Examples of retinoids include vitamin A compounds such as retinol, 3 - hydroxymretinol, retinal, 3 - hydroxymretinal, retinoic acid, 3 - dehydroretinoic acid, vitamin A acetate; carotenoids such as α,β,γ - carotene, β - cryptoxanthin, canthaxanthin; provitamin A compounds such as xanthophyll, etc.

[0130] Examples of oil - soluble derivatives of ascorbic acid include fatty acid esters of vitamin C such as L - ascorbyl stearate, L - ascorbyl tetraisopalmitate, L - ascorbyl palmitate, erythorbil palmitate, erythorbil tetraisopalmitate, ascorbyl dioleate; fatty acid esters of vitamin B6 such as pyridoxyl dipalmitate, pyridoxyl tripalmitate, pyridoxyl dilaurate, pyridoxyl dioctanoate, etc.

[0131] - UV Absorbent - Examples of UV absorbents include benzoic acid - type UV absorbents such as para - aminobenzoic acid; anthranilic acid - type UV absorbents such as methyl anthranilate; salicylic acid - type UV absorbents such as octyl salicylate; cinnamic acid - type UV absorbents such as isopropyl para - methoxycinnamate, octyl para - methoxycinnamate; UV absorbents such as urocanic acid, ethyl urocanate; benzophenone - type UV absorbents such as 2 - hydroxy - 4 - methoxybenzophenone, dihydroxybenzophenone; benzotriazole - type UV absorbents; 2 - phenylbenzimidazole - 5 - sulfonic acid, etc.

[0132] - Chelating Agent - Examples of chelating agents include citramalic acid, agaric acid, glyceric acid, shikimic acid, hinokitiol, gallic acid, tannic acid, caffeic acid, trisodium ethylenediamine-N,N,N',N'-tetraacetate dihydrate (EDTA-2Na), ethylenediamine diacetic acid, diethylenetriamine pentaacetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, analogs thereof, alkali metal salts thereof, carboxylic acid esters thereof, and the like.

[0133] -Preservative- Examples of preservatives include benzoic acid, salicylic acid, paraoxybenzoic acid esters (such as methyl paraben, ethyl paraben, butyl paraben, etc.), sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, phenoxyethanol, and the like.

[0134] -Plant extract- Examples of plant extracts include Saururus chinensis extract, Paeonia lactiflora extract, Glycyrrhiza glabra extract, Paeonia albiflora extract, Calendula officinalis extract, Luffa cylindrica extract, Saxifraga stolonifera extract, Eucalyptus globulus extract, Cinnamomum camphora extract, Malus sieversii extract, Youngia japonica extract, seaweed extract, Thymus vulgaris extract, and the like.

[0135] -Humectant- Examples of humectants include polyethylene glycol (hereinafter referred to as PEG), sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, glucosamine, cyclodextrin, and the like. Further, the glycols, the glycerins, the sugar alcohols, and the saccharides can also be used as humectants.

[0136] -Anti-inflammatory agent- Examples of anti-inflammatory agents include azulene, glycyrrhizin, lysozyme chloride, pyridoxine hydrochloride, sulfur, and the like.

[0137] -Whitening agent- Examples of the whitening agent include arbutin, 4-methoxysalicylic acid, tranexamic acid, ethyl vitamin C, magnesium ascorbyl phosphate, and the like.

[0138] -Cooling agent- Examples of the cooling agent include L-menthol, camphor, and the like.

[0139] -Antioxidant- Examples of the antioxidant include ascorbic acid, α-tocopherol, carotenoid, and the like.

[0140] <Dosage form> The dosage form of the cosmetic according to one embodiment is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include aqueous cosmetics, gel-like cosmetics, emulsified cosmetics, and the like.

[0141] The product form of the cosmetic according to one embodiment is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include facial or body skin care cosmetics such as lotion, emulsion, gel, essence, cream, etc., or hair care cosmetics; makeup cosmetics such as foundation and makeup base; sunscreen cosmetics; self-tanning cosmetics; skin cleansing cosmetics such as makeup remover; ointment, and the like. Further, the product form of the cosmetic according to one embodiment may be a form impregnated in a base material such as a pack. Among these, the product form of the cosmetic according to one embodiment is preferably a skin care cosmetic because it has excellent skin compatibility.

[0142] <Manufacturing method> The manufacturing method of the cosmetic according to one embodiment is not particularly limited and can be manufactured by a known water-in-oil type cosmetic manufacturing method, but can be preferably manufactured by the manufacturing method of the cosmetic according to one embodiment described later.

[0143] (Manufacturing method of cosmetic) The method for manufacturing a cosmetic according to one embodiment includes: (A) a step of dissolving a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof in an aqueous solvent (hereinafter, may be referred to as the "dissolving step"); (B) a liquid oil component that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid ester; and (C) a solid or semi-solid solid oil component that contains at least one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax. The step of obtaining an oil component mixture by liquefying the solid oil component at a temperature exceeding the melting points of the (B) liquid oil component and the (C) solid oil component (hereinafter, may be referred to as the "oil component mixture preparation step"); a step of adding the liquefied oil component mixture while stirring the aqueous solvent at a temperature exceeding the melting points of the (B) liquid oil component and the (C) solid oil component (hereinafter, may be referred to as the "oil component mixture addition step"); and a step of cooling the aqueous solvent added with the oil component mixture to a temperature of 25°C or lower to obtain a composition containing oily capsules (hereinafter, may be referred to as the "oily capsule preparation step"), and further includes other steps as necessary.

[0144]

Chem.

[0145] <Dissolving step> The dissolving step is a step of dissolving a pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof in an aqueous solvent. The pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof (component (A)) and the aqueous solvent are as described in the item of (cosmetic).

[0146] Since the (A) component is soluble in an aqueous solvent, there are no particular restrictions on the method for dissolving the (A) component in the aqueous solvent, and it can be carried out by a normal mixing method. For example, a method of dissolving using a mixer having stirring blades can be mentioned. Specific examples of mixers having stirring blades include propeller mixers, paddle mixers, and the like.

[0147] In the dissolution step, in addition to the (A) component, components soluble in the aqueous solvent described in the <other components> of the said (cosmetic) may be dissolved in the aqueous solvent. The mixing of the other components into the aqueous solvent may be carried out simultaneously with the mixing and dissolution of the (A) component, or separately.

[0148] <Oil component mixture preparation step> The oil component mixture preparation step is a step of obtaining an oil component mixture by liquefying a liquid oil component (component (B)) that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, and a solid or semi-solid solid oil component (component (C)) that contains at least one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax at a temperature exceeding the melting points of the said (B) liquid oil component and the said (C) solid oil component.

[0149] The liquid oil component (component (B)) that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, and the solid or semi-solid solid oil component (component (C)) that contains at least one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax are as described in the item of the said (cosmetic).

[0150] The temperature exceeding the melting points of components (B) and (C) means a temperature exceeding the respective melting points of components (B) and (C). However, since component (B) is liquid at 25°C, a temperature exceeding the melting point of component (C) is sufficient.

[0151] As a method for mixing the component (B) and the component (C), there are no particular limitations, and it can be carried out by a normal mixing method. For example, a method of mixing using a mixer having stirring blades can be mentioned. Specific examples of the mixer having stirring blades include a propeller mixer, a paddle mixer, and the like.

[0152] The oil mixture may contain, in addition to the component (B) and the component (C), the oily components described in the <other components> of the said (cosmetic). In this case, in the oil mixture preparation step, in addition to the component (B) and the component (C), the oily components described in the <other components> of the said (cosmetic) are added.

[0153] In the oil mixture preparation step, the component (B), the component (C), and other oily components may be dissolved simultaneously, or after dissolving combinations of one or more components respectively, they may be mixed to form an oil mixture.

[0154] In the oil mixture preparation step, the component (C) preferably acts as an amphiphilic substance, takes in the component (B) inside, and further, if necessary, other oily components, and forms micelles.

[0155] <Oil mixture addition step> The oil mixture addition step is a step of adding the liquefied oil mixture while stirring the aqueous solvent at a temperature exceeding the melting points of the (B) liquid oil and the (C) solid oil.

[0156] In the oil mixture addition step, the temperature of the aqueous solvent and the oil mixture is not particularly limited as long as it exceeds the melting points of the component (B) and the component (C), but it is preferable that the temperatures of the aqueous solvent and the oil mixture are substantially the same. In the method for producing a cosmetic according to an embodiment, "substantially the same temperature" means that the difference between the temperature of the aqueous solvent and the temperature of the oil mixture is preferably 10°C or less, preferably 5°C or less, more preferably 3°C or less, and it is even more preferable that there is no temperature difference (that is, the temperature difference is 0°C).

[0157] The stirring speed in the oil component mixture addition step is not particularly limited and can be appropriately selected according to the purpose. However, from the viewpoint of facilitating the production of a cosmetic containing oil capsules, 10 rpm to 1,500 rpm is preferable, and 20 rpm to 300 rpm is more preferable. Stirring can be carried out, for example, using a mixer having stirring blades. Specific examples of the mixer having stirring blades include a propeller mixer, a paddle mixer, and the like.

[0158] The method for adding the oil component mixture to the aqueous solvent is not particularly limited and can be appropriately selected according to the purpose. However, from the viewpoint of facilitating the production of a cosmetic containing oil capsules, a method of adding at a constant rate using an injection means such as a liquid delivery pump is preferable. Further, as the method for adding the oil component mixture to the aqueous solvent, a method of directly injecting the oil component mixture from the lower part of the aqueous solvent is preferable because it is difficult for the oil component mixture to float and separate in the aqueous solvent and oil capsules with a uniform particle diameter can be formed.

[0159] <Oil Capsule Preparation Step> The oil capsule preparation step is a step of cooling the aqueous solvent added with the oil component mixture to a temperature of 25°C or lower to obtain a composition containing oil capsules.

[0160] In the oil capsule preparation step, it is preferably carried out with stirring when cooling to a temperature of 25°C or lower. The stirring speed in the oil capsule preparation step is not particularly limited and can be appropriately selected according to the purpose. However, it is preferably the same stirring speed and stirring method as in the oil component mixture addition step.

[0161] Since the component (C) in the oil component mixture is solid or semi-solid at 25°C, it precipitates when cooled to a temperature of 25°C or lower. In the oil component mixture preparation step, the micelle having the component (B) and other oil components as the inner phase and the component (C) as the outer phase becomes an oil capsule in which the component (C) becomes solid or semi-solid due to the precipitation of the component (C) in the oil capsule preparation step. In this way, oil capsules are formed in the aqueous solvent.

[0162] <Other Steps> As for other steps, there are no particular limitations, and they can be appropriately selected according to the purpose. For example, there is a step of crystallizing the component (C). When the solid oil component forming the outer phase of the oil-based capsule is crystallized, it can have an appropriate hardness and produce a unique feeling of use.

[0163] In addition, the method for manufacturing a cosmetic according to one embodiment may include other treatment steps according to the product form of the target cosmetic.

Examples

[0164] Examples and comparative examples are given below to more specifically explain the embodiments, but the embodiments are not limited by these examples and comparative examples. In the examples and comparative examples, the content of each component shown in Tables 1 and 2 below indicates "mass%" based on the total mass of the cosmetic, and all values are in terms of pure components.

[0165] (Examples 1 to 4) Each component was mixed with the composition and content (mass%) shown in Table 1 below to prepare the oil-in-water type cosmetics of Examples 1 to 4, respectively. Specifically, first, the component (A) and water-soluble components among other components other than water were added to water to prepare an aqueous solvent. Next, the component (B), the component (C), and the oil-based components among other components were added and melted at 70°C to 80°C to prepare an oil-based component mixture. Then, the aqueous solvent was heated to 70°C to 80°C, and while stirring at 250 rpm using a propeller mixer, the oil-based component mixture was added into the aqueous solvent at a rate of 20 mL / min using a liquid delivery pump. At this time, the oil-based component mixture was injected from the lower part of the aqueous solvent. After the injection of the oil-based component mixture into the aqueous solvent was completed, the stirring speed was reduced to 150 rpm, and after cooling to room temperature (25°C ± 5°C), potassium hydroxide was added to obtain the oil-in-water type cosmetics of Examples 1 to 4 containing oil-based capsules.

[0166] (Comparative Example 1) In the preparation of the oil-in-water cosmetics of Examples 1 to 4, an oil-in-water cosmetic of Comparative Example 1 containing oily capsules was obtained in the same manner as the preparation method of the oil-in-water cosmetics of Examples 1 to 4, except that the component (A) was not added, according to the composition and content (mass%) shown in Table 1 below.

[0167] (Examples 5 to 7) In the preparation of the oil-in-water cosmetics of Examples 1 to 4, an oil-in-water cosmetic of Examples 5 to 7 containing oily capsules was obtained in the same manner as the preparation method of the oil-in-water cosmetics of Examples 1 to 4, except that the composition and content (mass%) shown in Table 2 below were changed to the composition and content (mass%) shown in Table 2 below.

[0168] (Comparative Example 2) In the preparation of the oil-in-water cosmetics of Examples 5 to 7, an oil-in-water cosmetic of Comparative Example 2 containing oily capsules was obtained in the same manner as the preparation method of the oil-in-water cosmetics of Examples 5 to 7, except that the component (A) was not added, according to the composition and content (mass%) shown in Table 2 below.

[0169] <Evaluation of skin familiarity>[ The skin familiarity of the cosmetics of Examples 1 to 7 and Comparative Examples 1 and 2 was evaluated by the following method.

[0170] Five professional evaluators confirmed the skin familiarity when applying the cosmetics of Examples 1 to 7 and Comparative Examples 1 and 2 to the skin respectively, and evaluated them according to the following evaluation criteria. In addition, the cosmetics of Examples 1 to 4 were evaluated with the cosmetics of Comparative Example 1 as a control, and the cosmetics of Examples 5 to 7 were evaluated with the cosmetics of Comparative Example 2 as a control. The evaluation results are shown in Tables 1 and 2 below. [Evaluation criteria for skin familiarity] A: Four or more out of five answered that the skin familiarity was better compared to the control cosmetics. B: Three or fewer out of five answered that the skin familiarity was better compared to the control cosmetics.

[0171]

Table 1

[0172]

Table 2

[0173] The 2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride (dimethylpyrazolyldimethylpyrimidine hydrochloride) of component (A) used in the examples is a compound represented by the following structural formula (1), which was produced by the method described in Patent No. 4586108.

[0174]

Chemical formula

[0175] Examples of the embodiments of the present invention include the following. <1> (A) A pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof, and

[0176]

Chemical formula

[0177]

Chemical formula

[0178] As described above, the present invention has been described based on specific embodiments and examples. However, these embodiments and examples are merely presented as examples, and the present invention is not limited by the above embodiments and examples. The above embodiments can be implemented in various other forms, and various combinations, omissions, replacements, additions, changes, etc. can be made without departing from the gist of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are included in the invention described in the claims and its equivalent scope.

Claims

1. (A)A pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof, and 【Chemical Formula 1】 (In the general formula (1), R １ , R ３ , R ４ , and R ６ each independently represents an alkyl group having 1 to 3 carbon atoms; R ２ and R ５ each independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. (B)A liquid oil component that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, and (C)A solid or semi-solid solid oil component that is solid or semi-solid at 25°C and contains at least one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax, A cosmetic characterized by containing the above.

2. R in the above-mentioned (A) pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof ２ and R ５ The cosmetic according to claim 1, wherein is a hydrogen atom.

3. R in the above-mentioned (A) pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof １ , R ３ , R ４ , and R ６ is a methyl group, The cosmetic according to claim 1 or 2.

4. The cosmetic according to Claim 1, wherein the content of the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof in (A) is 0.1% by mass to 1% by mass.

5. The cosmetic according to Claim 1, which contains oily capsules having an average particle diameter of 100 μm or more and containing the liquid oil component in (B) and the solid oil component in (C).

6. (A)A step of dissolving a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof in an aqueous solvent; 【Chemical 2】 (In the general formula (1), R １ , R ３ , R ４ , and R ６ each independently represent an alkyl group having 1 to 3 carbon atoms, and R ２ and R ５ each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.) (B)A step of liquefying a liquid oil component that is liquid at 25°C and contains at least one selected from the group consisting of silicone oil and polyhydric alcohol fatty acid esters, and a solid or semi-solid solid oil component that is solid or semi-solid at 25°C and contains at least one selected from the group consisting of glyceryl monoalkyl ether, a higher alcohol having 18 or more carbon atoms, and candelilla wax at a temperature exceeding the melting points of the liquid oil component in (B) and the solid oil component in (C) to obtain an oil component mixture; A step of adding the liquefied oil component mixture while stirring the aqueous solvent at a temperature exceeding the melting points of the liquid oil component in (B) and the solid oil component in (C); A step of cooling the aqueous solvent added with the oil component mixture to a temperature of 25°C or lower to obtain a composition containing oily capsules; A method for producing a cosmetic, characterized by including the above steps.

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