Azelaic acid production promoter, adenosine production promoter, and vitamin b production promoter

Abstract

To provide a novel azelaic acid production promoter, adenosine production promoter, and vitamin B production promoter.SOLUTION: The present invention provides an azelaic acid production promoter, an adenosine production promoter, and a vitamin B production promoter, each containing a red clover flower extract as an active ingredient.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to an azelaic acid production promoter, an adenosine production promoter, and a vitamin B production promoter. More specifically, it relates to an azelaic acid production promoter, an adenosine production promoter, and a vitamin B production promoter containing an extract of Akatsukimekusa flower as an active ingredient.

Background Art

[0002] The extract of Akatsukimekusa flower is known to have anti-inflammatory, antioxidant, estrogen-like, ceramidase inhibitory, elastase inhibitory, hair treatment effects, etc. Patent Document 1 discloses an antioxidant preparation containing at least two extracts selected from bilberry extract, Akatsukimekusa flower extract, etc. and vitamin E and / or C. Patent Document 2 reports a synergistic effect between an estrogen-like agent selected from dulse extract, red clover extract, etc. and chlorella extract, an active oxygen scavenger, and an anti-inflammatory agent, which are collagen production promoters. Patent Document 3 discloses a ceramidase activity inhibitor characterized by containing extracts derived from various plants such as the Malvaceae family, the Rubiaceae family, the Poaceae family, etc., including the Fabaceae family to which Trifolium, to which Akatsukimekusa belongs, belongs, as active ingredients. Patent Document 4 reports the elastase inhibitory effects of various plants such as mushrooms belonging to the genus Fuscospora and plants belonging to the genus Trifolium, to which Akatsukimekusa belongs, including the genus Vitis and the genus Oenothera.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Patent Document 5

SUMMARY OF THE INVENTION

PROBLEM TO BE SOLVED BY THE INVENTION

[0004] An object of the present invention is to provide a novel function of an extract of Akatsukimekusa flowers.

MEANS FOR SOLVING THE PROBLEM

[0005] As a result of intensive research on the effects of an extract of Akatsukimekusa flowers, the present inventors have found that the extract of Akatsukimekusa flowers has a particularly high effect on promoting the production of azelaic acid, promoting the production of adenosine, and promoting the production of B vitamins, in addition to the known effects as described above, and have completed the following invention. (1) An azelaic acid production promoter containing an extract of Akatsukimekusa flowers as an active ingredient. (2) An adenosine production promoter containing an extract of Akatsukimekusa flowers as an active ingredient. (3) A B vitamin production promoter containing an extract of Akatsukimekusa flowers as an active ingredient. (4) The B vitamin production promoter according to (3), wherein the B vitamins are pyridoxine or pantothenic acid. (5) A composition for suppressing skin pigmentation, suppressing papules, or suppressing pustules, containing the azelaic acid production promoter according to (1). (6) A composition for promoting blood flow, containing the adenosine production promoter according to (2). (7) A composition for improving rough skin, suppressing sebum secretion, or promoting wound healing, containing the B vitamin production promoter according to (3) or (4). (8) A composition for suppressing skin pigmentation, suppressing papules, suppressing pustules, promoting blood flow, improving rough skin, suppressing sebum secretion, or promoting wound healing, containing an extract of Akatsukimekusa flowers as an active ingredient.

EFFECTS OF THE INVENTION

[0006] According to the present invention, it is possible to promote azelaic acid production, adenosine production, and vitamin B production. Further, according to the present invention, it becomes possible to suppress skin pigmentation, suppress papules, suppress pustules, promote blood flow, improve rough skin, suppress sebum secretion, and promote wound healing.

Brief Description of the Drawings

[0007]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Modes for Carrying Out the Invention

[0008] The present invention provides a promoter for promoting the production of azelaic acid, a promoter for promoting the production of adenosine, and a promoter for promoting the production of B vitamins, which contain akatsume kesa flower extract as an active ingredient. By promoting the production of azelaic acid, pigmentation, papules, and pustules of the skin can be suppressed. By promoting the production of adenosine, blood flow can be promoted. By promoting the production of B vitamins, rough skin can be suppressed, sebum secretion can be suppressed, and wound healing can be promoted.

[0009] The promotion of the production of azelaic acid, adenosine, or B vitamins means that, for example, when the agent or composition of the present invention is applied, the production amount of azelaic acid, adenosine, or B vitamins is increased with a statistically significant difference (for example, a t-test) with a significance level of 5% compared to the state without application (control), or is increased by, for example, 10% or more, 20% or more, 30% or more, 40% or more, 50% or more, 60% or more, 70% or more, 80% or more, 90% or more, 100% or more, 200% or more, 300% or more, 400% or more, or 500% or more. The production amount of azelaic acid, adenosine, or B vitamins can be determined, for example, by metabolome analysis as described in Patent Document 5 or Examples to determine the amount of these metabolites in vivo, or can also be determined by any known technique such as measuring the amount of azelaic acid, adenosine, or B vitamins.

[0010] Azelaic acid (CAS No.: 123-99-9) is a saturated dicarboxylic acid in the form of a white powder, and is known to have effects such as suppressing acne, pigmentation, papules, and pustules (Sci Rep. 2020 Jul 28;10(1):12612.doi:10.1038 / s41598-020-69530-w). Adenosine (CAS No.: 58-61-7) is a nucleoside composed of adenine and ribose, and is known to have effects such as reducing wrinkles, promoting blood flow, and promoting hair growth (Nat Neurosci. 2010 Jul;13(7):883-8.doi:10.1038 / nn.2562.Epub 2010 May 30). The B vitamins include vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid, or biotin, and are known to have effects such as improving rough skin, suppressing sebum secretion, or promoting wound healing. For example, vitamin B1 is involved in glycolysis, etc., vitamin B2 is involved in lipid metabolism, etc., vitamin B6 is involved in maintaining immune function, enhancing skin resistance, synthesizing hemoglobin in red blood cells, synthesizing neurotransmitters, lipid metabolism, etc., vitamin B12 is involved in the biosynthesis of proteins and nucleic acids, the metabolism of amino acids and fatty acids, etc., niacin is involved in the metabolism of carbohydrates, lipids, proteins, etc., folic acid is involved in the synthesis of red blood cells, etc., and biotin is known to be involved in anti-inflammation, etc. Pantothenic acid (CAS No.: 137-08-6) is a type of B vitamin also called D(+)-N-(2,4-dihydroxy-3,3-dimethylbutyryl)-β-alanine, and is known to have effects such as improving rough skin, accelerating re-epithelialization in wound healing, and suppressing acne (Am J Clin Dermatol. 2002;3(6):427-33.doi:10.2165 / 00128071-200203060-00005). Pyridoxine is a type of vitamin B6, and is known to have effects such as suppressing excessive sebum secretion, improving rough skin, suppressing acne, and promoting filaggrin production (Mol Biol Rep. 2021 Jul;48(7):5513-5518.doi:10.1007 / s11033-021-06563-y.Epub 2021 Jul 24). In one embodiment, the B vitamins are vitamin B6 or pantothenic acid, and in one aspect of such an embodiment, vitamin B6 is pyridoxine.

[0011] Therefore, the present invention also provides a composition containing an extract of Rosa multiflora var. cathayensis flowers as an active ingredient for inhibiting skin pigmentation, suppressing papules, suppressing pustules, promoting blood flow, improving rough skin, suppressing sebum secretion, promoting wound healing, or for improving acne marks, skin smoothness, skin texture, brightness, dullness, or transparency. Some embodiments of the composition of the present invention include a composition containing an extract of Rosa multiflora var. cathayensis flowers as an active ingredient for inhibiting skin pigmentation, suppressing papules, or suppressing pustules through promoting azelaic acid production; a composition containing an extract of Rosa multiflora var. cathayensis flowers as an active ingredient for promoting blood flow through promoting adenosine production; or a composition containing an extract of Rosa multiflora var. cathayensis flowers as an active ingredient for improving rough skin, suppressing sebum secretion, or promoting wound healing through promoting the production of B vitamins. Some embodiments of the composition of the present invention include a composition for inhibiting skin pigmentation, suppressing papules, or suppressing pustules containing a promoter for promoting azelaic acid production containing an extract of Rosa multiflora var. cathayensis flowers as an active ingredient; a composition for promoting blood flow containing a promoter for promoting adenosine production containing an extract of Rosa multiflora var. cathayensis flowers as an active ingredient; or a composition for improving rough skin, suppressing sebum secretion, or promoting wound healing containing a promoter for promoting the production of B vitamins containing an extract of Rosa multiflora var. cathayensis flowers as an active ingredient.

[0012] The effects of inhibiting skin pigmentation, suppressing papules, suppressing pustules, promoting blood flow, improving rough skin, suppressing sebum secretion, or promoting wound healing can be determined, for example, by subjective, objective, or evaluation using a specific device as in the examples, or by any other known technique.

[0013] In addition, according to the present invention, since it is possible to simultaneously promote azelaic acid production, adenosine production, and the production of B vitamins, it is also possible to simultaneously exhibit effects such as inhibiting skin pigmentation, papules, and pustules, promoting blood flow, and improving rough skin, suppressing sebum secretion, and promoting wound healing. As a result, it leads to the improvement of acne marks, skin smoothness, skin texture, brightness, dullness, and transparency, and a composite effect can be expected.

[0014] Red clover flower extract is an extract obtained by extracting the flowers of red clover (scientific name: Trifolium pratense). As described above, red clover flower extract is known to have anti-inflammatory, antioxidant, estrogen-like, ceramidase inhibitory, elastase inhibitory, hair treatment, etc. (Patent Documents 1 to 4). The present inventors have discovered that red clover flower extract has a high azelaic acid, adenosine, or vitamin B production promoting effect.

[0015] The method for extracting red clover flower extract can be carried out, for example, by solvent extraction. In the case of solvent extraction, red clover flowers are dried as necessary, and further chopped or crushed as necessary, and then extracted with an aqueous extractant, water, for example, cold water, warm water, or hot water at or below the boiling point, or a water-containing organic solvent, for example, water-containing ethanol, water-containing methanol, water-containing ether, water-containing 1,3-butylene glycol, etc., or an organic solvent, for example, ethanol, methanol, ether, 1,3-butylene glycol, etc., selected appropriately according to the properties of the raw material and the use of the composition, at room temperature or with heating. However, the extraction method is not limited to solvent extraction, and may be a conventional method known in the art, and the extraction method and form of the extract used in the present invention are arbitrary as long as they do not impair the effects of the present invention. The form of the extract may be not only the extract itself, but also a product appropriately diluted or concentrated by a conventional method, and may further be a powder or lump solid obtained by drying the extract, or a squeezed juice appropriately diluted or concentrated by a conventional method.

[0016] Examples of the organic solvent include lower alcohols (e.g., C1 to C4) such as ethanol, methanol, isopropanol, propylene glycol, and 1,3-butylene glycol. Examples of the water-containing organic solvent include water-containing products of the above-mentioned lower alcohols, and in this case, the water content may be, for example, 0 to 10 v / v%, 10 to 40 v / v%, 20 to 30 v / v%, 30 to 40 v / v%, 30 to 50 v / v%, 60 to 70 v / v%, 50 to 80 v / v%, or 80 to 99.5 v / v%.

[0017] The azelaic acid production promoter, adenosine production promoter, and vitamin B production promoter of the present invention (hereinafter sometimes collectively referred to as "the agent of the present invention") may be formulated in a composition such as cosmetics and applied to the skin, or may be formulated in a composition such as pharmaceuticals and quasi-drugs and topically administered to animals such as humans. It may also be formulated in a composition such as various foods, food and drink products, nutritional supplements such as supplements, and orally administered to animals such as humans, or may be administered to animals such as humans as a pharmaceutical preparation. As the form of skin application or topical administration, for example, creams, emulsions, liquids, sheets, sprays, gels, etc. can be arbitrarily selected. As the form of oral administration, for example, tablets, beverages, powders, etc. can be arbitrarily selected. However, the administration form is not limited to those described above.

[0018] The cosmetic composition of the present invention may be various cosmetics such as emulsions, creams, beauty essences, lotions, packs, facial cleansers, soaps, body soaps, shampoos, microneedles, and fine needle-like structures, and may be in various forms such as liquid, emulsion, cream, solid, sheet, spray, gel, foam, powder, and fine needle-like. Also, the food composition of the present invention may be a powder, beverage, or tablet, and may be in various forms such as powdery, liquid, solid, granular, pellet-like, paste-like, and gel-like.

[0019] The frequency of application can be arbitrarily selected, such as once every four weeks, once every two weeks, once a week, once every three days, once every two days, once a day, twice a day, three times a day, four times a day, five times a day, or administration each time, but is not limited to these.

[0020] The agent or composition of the present invention preferably contains an extract of Akatsukemeksa flower, or a plant of the genus Shajikisou in the legume family that is similar in properties thereto, or a composition known to be contained in the extract of Akatsukemeksa flower, for example, formononetin or biochanin A, in an amount sufficient to exert an effect of promoting the production of azelaic acid, adenosine, or vitamins B, or an effect of suppressing skin pigmentation, papule formation, pustule formation, promoting blood flow, improving rough skin, suppressing sebum secretion, or promoting wound healing, and can be appropriately determined according to their types, purposes, forms, usage methods, etc. For example, in certain embodiments, the agent of the present invention can contain an extract of Akatsukemeksa flower as an active ingredient in an amount of, for example, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, 50% by weight or more, 60% by weight or more, 70% by weight or more, 80% by weight or more, 90% by weight or more, 95% by weight or more, or 99% by weight or more. In certain embodiments, the agent of the present invention may consist of an extract of Akatsukemeksa flower. For example, in certain embodiments, the amount of the extract of Akatsukemeksa flower (dry weight) per total weight of the composition of the present invention can be 0.0001 to 0.0005% by weight, 0.0005 to 0.001% by weight, 0.001 to 0.005% by weight, 0.005 to 0.01% by weight, 0.01 to 0.05% by weight, 0.01 to 5.0% by weight, 0.05 to 0.1% by weight, 0.05 to 1.0% by weight, 0.1 to 0.5% by weight, 0.1 to 1.0% by weight, 0.5 to 5.0% by weight, 1.0 to 5.0% by weight, 5.0 to 10.0% by weight, 10.0 to 50.0% by weight, 50.0 to 100.0% by weight.

[0021] Additives can be arbitrarily selected and used in combination with the agent or composition of the present invention as needed. Excipients and the like can be included as additives.

[0022] As excipients, any excipients can be used as long as they are commonly used when the desired dosage form is obtained. For example, starches such as wheat starch, rice starch, corn starch, potato starch, dextrin, cyclodextrin, crystalline celluloses, lactose, glucose, sucrose, reduced maltose, malt syrup, fructooligosaccharide, emulsified oligosaccharide and other saccharides, sugar alcohols such as sorbitol, erythritol, xylitol, lactitol, mannitol, etc. can be mentioned. These excipients can be used alone or in combination of two or more.

[0023] As other additives, known substances such as coloring agents, preservatives, thickening agents, binders, disintegrants, dispersants, stabilizers, gelling agents, antioxidants, surfactants, preservatives, pH adjusters, oils, water, alcohols, chelating agents, silicones, ultraviolet absorbers, moisturizers, fragrances, various medicinal components, antiseptics, neutralizing agents, etc. can be appropriately selected and used.

[0024] In addition, the present invention also provides a method for suppressing skin pigmentation, suppressing papules, suppressing pustules, promoting blood flow, improving rough skin, suppressing sebum secretion, promoting wound healing, or improving acne marks, skin smoothness, skin feel, brightness, dullness, or transparency on the skin by applying the extract of Akatsukemex flower. Some embodiments of such invention are: a method for suppressing skin pigmentation, suppressing papules, or suppressing pustules by promoting the production of azelaic acid through applying the extract of Akatsukemex flower; a method for promoting blood flow by promoting the production of adenosine through applying the extract of Akatsukemex flower; or a method for improving rough skin, suppressing sebum secretion, or promoting wound healing by promoting the production of B vitamins through applying the extract of Akatsukemex flower. One embodiment of the method of the present invention is a method for cosmetic purposes, excluding medical acts by doctors and medical staff. In one aspect of such embodiment, the agent or composition of the present invention is applied to the skin as a cosmetic.

[0025] Furthermore, the present invention also provides the use of the extract of the flower of Aka Tsumex in the manufacture of a medicament for promoting the production of azelaic acid, adenosine, or B vitamins. The present invention also provides the use of the extract of the flower of Aka Tsumex in the manufacture of a medicament for suppressing skin pigmentation, suppressing papules, suppressing pustules, promoting blood flow, improving rough skin, suppressing sebum secretion, promoting wound healing, or improving acne marks, skin smoothness, skin texture, brightness, dullness, or transparency. The present invention also provides an extract of the flower of Aka Tsumex for use in suppressing skin pigmentation, suppressing papules, suppressing pustules, promoting blood flow, improving rough skin, suppressing sebum secretion, promoting wound healing, or improving acne marks, skin smoothness, skin texture, brightness, dullness, or transparency. In one embodiment of such use, the action of suppressing skin pigmentation, suppressing papules, or suppressing pustules is achieved by promoting the production of azelaic acid in skin cells such as keratinocytes; the action of promoting blood flow is achieved by promoting the production of adenosine; or the action of improving rough skin, suppressing sebum secretion, or promoting wound healing of the skin is achieved by promoting the production of B vitamins in skin cells such as keratinocytes.

Example

[0026] Next, the present invention will be described in more detail by way of examples. It should be noted that the present invention is not limited thereto.

[0027] Example 1: Promoting effect of the extract of the flower of Aka Tsumex on the production of azelaic acid, adenosine, and B vitamins such as pantothenic acid and pyridoxine 1. Preparation of samples As the sample of the extract of the flower of Aka Tsumex, the extract of the flower of Aka Tsumex (product name Stem Clover RF) manufactured by Technoble was used.

[0028] 2. Culture of normal human epidermal keratinocytes Normal human neonatal male epidermal keratinocytes were pre-cultured in a medium for human epithelial cells (CELLnTEC) for 24 hours and then cultured at an oxygen pressure of 3% for 4 hours. After culturing, the medium was replaced with a medium containing 0.38% by weight of the extract of the flower of Aka Tsumex per medium. As a control, culturing was performed under the same conditions in a medium having the same composition except that the extract of the flower of Aka Tsumex was not added.

[0029] 3. Metabolome Pretreatment Metabolome pretreatment was performed according to the method described in Patent Document 5. More specifically, after culturing the above epidermal keratinocytes, the medium was removed, and mannitol washing was performed twice. A methanol solution was added thereto and stirred. Milli-Q water containing 1 μM of the internal standard substance was added thereto and stirred, followed by centrifugation (2,300×g, 4°C, 5 minutes). After centrifugation, the extract was transferred to an ultrafiltration tube (Ultrafree MC PLHCC, HMT, centrifugal filter unit 5 kDa). This was centrifuged (9,100×g, 4°C, 120 minutes) and subjected to ultrafiltration treatment. The filtrate was dried and dissolved again in Milli-Q water for measurement. 1.26×10 6 cells per sample were used, and the measurement was carried out with N = 5.

[0030] 4. Detection of Metabolites Detection of metabolites was performed according to the method described in Patent Document 5. More specifically, cationic metabolites and anionic metabolites were comprehensively detected by a CE-MS system combining capillary electrophoresis (Agilent CE system) and a mass spectrometer (MS). From the detected peaks, peaks with a signal / noise (S / N) ratio of 3 or more were automatically extracted using automatic integration software to obtain the mass-to-charge ratio (m / z), peak area value, and migration time (MT). Based on the values of m / z and MT, a comparison and search were performed with all substances registered in the HMT metabolite library to identify the amount of metabolites, and the relative area value was calculated using the following calculation formula.

[0031]

Equation

[0032] The results are shown in Fig. 1 and Table 1. Fig. 1 shows the results of comparing the relative area values of azelaic acid, adenosine, pantothenic acid, and pyridoxine when the extract of Akatsukemakusa flower was added with those of the non-added control. Table 1 shows the relative values of the amounts of various metabolites in keratinocytes to which the extract of Akatsukemakusa flower was added, with the amount in the control being set to 1.

[0033]

Table 1

[0034] From Fig. 1 and Table 1, it was confirmed that the extract of Akatsukemakusa flower has a significant promoting effect on the production of vitamins B such as azelaic acid, adenosine, pantothenic acid, and pyridoxine in epidermal keratinocytes as compared with the control.

[0035] Example 2: Various effects of the extract of Akatsukemakusa flower on the skin 1. Improvement of rough skin An oil-in-water cream containing 0.38% by weight of the extract of Akatsukemakusa flower was applied to 36 healthy human subjects aged from their 40s to 60s. After continuous use daily for 6 weeks, the state of rough skin on the cheeks 2 weeks, 4 weeks, and 6 weeks after continuous use was evaluated by professional evaluators using a rough skin score on a 10-point scale from "very smooth" to "very rough" as described in Table 2 below, and a significance test was performed by Wilcoxon's signed-rank test.

Table 2

[0036] The results are shown in Fig. 2. As shown in Fig. 2, improvement of rough skin was observed 2 weeks, 4 weeks, and 6 weeks after using the cosmetic containing the extract of Akatsukemakusa flower.

[0037] 2. Improvement of skin smoothness, brightness, blood flow, dullness, and acne marks A water-in-oil cream containing 0.38% by weight of the extract of Anemone vitifolia Buch.-Ham. was applied to 126 healthy subjects aged from their 40s to 70s, and used daily for 42 consecutive days. The subjects were asked to evaluate the improvement effects on skin smoothness, brightness, blood flow, dullness, and acne marks as "yes" or "no" according to the criteria shown in Figure 3, and compared with before the start of the test.

[0038] The results are shown in Figure 3. As shown in Figure 3, it was revealed that using the cosmetics containing the extract of Anemone vitifolia Buch.-Ham. could bring about the improvement in skin smoothness, brightness, blood flow, dullness, and acne marks.

[0039] 3. Improvement in Skin Brightness and Transparency A cosmetic containing 0.38% by weight of the extract of Anemone vitifolia Buch.-Ham. was used every other day for 11 days for 34 healthy human subjects aged from their 40s to 50s by a method of incorporating it into the stratum corneum of the cheek skin using fine needle-like structures, and then used daily for 42 days once a week. The changes in the skin were compared with before the start of use. The above fine needle-like structures are cosmetics. First, for the darkness of the skin color and skin opacity in appearance, evaluations were made by professional evaluators before the start of the test, 12 days later, 24 days later, and 48 days later. The evaluation of the darkness of the skin color was carried out in 10 grades using a pre-prepared color scale. The evaluation of skin opacity was carried out using a 10-grade skin turbidity score with "very transparent skin, thin, skin color like pottery, fine texture" as grade 0 and "opaque skin, thick, grayish, rough texture" as grade 9. Furthermore, the measurement of skin brightness (L value) using a spectrophotometer CM2600d (Konica Minolta) and the measurement of skin transparency (K value) using a semi-transparency measuring device TLS855 (Dia-Stron) were carried out. A significance test was performed by Wilcoxon's signed-rank test.

[0040] The results are shown in Fig. 4. As shown in Fig. 4, by using a cosmetic containing the extract of Anemone vitifolia Buch.-Ham. flower, improvement in skin brightness and transparency was observed at all time points 12 days, 24 days, and 48 days after use (Figs. 4A and 4B). Also, improvement was observed in the L value indicating skin brightness and the K value indicating skin transparency at all time points 12 days, 24 days, and 48 days after use (Figs. 4C and 4D).

[0041] 4. Improvement effects on skin smoothness, brightness, texture, and blood flow A method of incorporating into the stratum corneum of the cheek skin using a fine needle-like structure containing 0.38% by weight of the extract of Anemone vitifolia Buch.-Ham. flower was used for 11 days every other day on 101 healthy human subjects in their 40s to 50s, and then used daily for 42 days once a week. The improvement effects on skin smoothness, brightness, texture, and blood flow were evaluated according to the criteria described in Fig. 5 and compared with before the start of the test. Note that the above fine needle-like structure is a cosmetic.

[0042] The results are shown in Fig. 5. As shown in Fig. 5, it became clear that by using a cosmetic containing the extract of Anemone vitifolia Buch.-Ham. flower, the improvement effects on skin smoothness, brightness, texture, and blood flow can be felt.

Industrial Applicability

[0043] According to the present invention, by administering an agent or composition containing the extract of Anemone vitifolia Buch.-Ham. flower as an active ingredient, various effects such as suppression of pigmentation, suppression of papules, suppression of pustules, promotion of blood flow, improvement of rough skin, suppression of sebum secretion, promotion of wound healing, and improvement of acne marks, skin smoothness, texture, brightness, dullness, and transparency can be expected.

Claims

1. A azelaic acid production promoter containing an extract of Akatsume kesa flower as an active ingredient.

2. An adenosine production promoter containing an extract of Akatsume kesa flower as an active ingredient.

3. A vitamin B production promoter containing an extract of Akatsume kesa flower as an active ingredient.

4. The vitamin B production promoter according to Claim 3, wherein the vitamin B is pyridoxine or pantothenic acid.

5. A composition for inhibiting skin pigmentation, suppressing papules, or suppressing pustules, containing the azelaic acid production promoter according to Claim 1.

6. A composition for promoting blood flow, containing the adenosine production promoter according to Claim 2.

7. A composition for improving rough skin, suppressing sebum secretion, or promoting wound healing, containing the vitamin B production promoter according to Claim 3 or 4.

8. A composition for inhibiting skin pigmentation, suppressing papules, suppressing pustules, promoting blood flow, improving rough skin, suppressing sebum secretion, or promoting wound healing, containing an extract of Akatsume kesa flower as an active ingredient.

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