Pore visibility improver

Abstract

To provide a pore visibility improver.SOLUTION: We have found that ectoine has the effect of improving pore visibility, specifically, it reduces the pore score and the number of visible pores or inhibits an increase, thereby improving pore visibility. That is, one aspect of the present invention is a pore visibility improver containing ectoine. The pore visibility improver of the present invention can be used for applications such as cosmetics, quasi-drugs, and pharmaceuticals. The pore visibility improver of the present invention is preferably provided in a dosage form that can be applied to the skin, such as a lotion, cream, milky lotion, gel, or pack.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a pore visibility improver.

Background Art

[0002] The visibility of pores is a common concern across all generations, and there is a need for methods to improve this visibility. So far, a horny plug decomposition promoter containing an aqueous extract of a gardenia fruit (Patent Document 1), a skin external preparation containing a peach leaf extract or a silver birch leaf extract and polyethylene glycol with a weight average molecular weight of 2000 to 5000 (Patent Document 2), a pore visibility improver containing a fermentation composition containing a fermented product of a fungus belonging to the genus Galactomyces of olive leaves or an extract thereof (Patent Document 3), a cosmetic excellent in pore improvement effect having a humus extract as an active ingredient (Patent Document 4), a pore improvement composition containing an extract of elm bark, an extract of Bodaiju, an extract of Buttonpi, an extract of Bergenia ligulata, an extract of Acentyak, an extract of olive, an extract of Gorenji, or an extract of cherry, and retinol or a retinol derivative (Patent Document 5), etc. have been developed.

[0003] Ectoine, which is a kind of cyclic amino acid, is abundant in alkalophilic microorganisms and is widely used as a cosmetic additive. As the function of ectoine, it is known to retain moisture by generating a hydration nucleus and protect cells from drying, ultraviolet rays, air pollutants, temperature, chemical substances, etc. (Non-Patent Document 1). Furthermore, ectoine suppresses the carbonylation of proteins on the skin (Non-Patent Document 2) and is known to have an effect of suppressing skin dullness (Non-Patent Document 3).

[0004] While the effect of ectoine on skin color tone has been shown, there has been no report so far that ectoine can improve the visibility of pores due to morphological changes, and there has also been no report that it acts on pore score or number.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Patent Document 5

Summary of the Invention

Problems to be Solved by the Invention

[0006] An object of the present invention is to provide a pore visibility improving agent.

Means for Solving the Problems

[0007] As a result of intensive studies to solve the above problems, the present inventors have found that ectoine has an effect of improving pore visibility, and have completed the present invention.

[0008] That is, the present invention is (1) A pore visibility improving agent containing ectoine, (2) The pore visibility improving agent according to (1), which reduces the size of pores, (3) The pore visibility improving agent according to (1), which reduces the number of prominent pores, (4) A cosmetic or external skin preparation containing the pore visibility improving agent according to (1) to (3), (5) The external skin preparation according to (4), which is a quasi-drug or a medicine, (6) The cosmetic or external skin preparation according to (4) or (5), wherein the content of ectoine is 1 w / w% or more based on the total amount of the cosmetic or external skin preparation, is.

Effects of the Invention

[0009] According to the present invention, it has become possible to provide an excellent pore visibility improving agent.

BEST MODE FOR CARRYING OUT THE INVENTION

[0010] In the present invention, improving the visibility of pores means improving the visibility of pores on the skin. For example, it means reducing the size of pores, decreasing the number of prominent pores, suppressing an increase in the number of prominent pores, and the like. The ectoine of the present invention has an effect of improving the visibility of pores. As the ectoine of the present invention, those of the quality usually used in cosmetics, pharmaceuticals, or quasi-drugs can be appropriately used. The content of the ectoine of the present invention is preferably 0.01 to 20 w / w%, more preferably 0.1 to 10 w / w%, still more preferably 1 to 7 w / w%, and most preferably 2 to 5 w / w% based on the total amount of the cosmetic or external preparation for skin.

[0011] The improving effect on the visibility of pores of the present invention can be confirmed, for example, using a skin analyzer VISIA Evolution (manufactured by Canfield Scientific Inc.).

[0012] In addition to the ectoine of the present invention, the cosmetic and external preparation for skin of the present invention can be appropriately blended with various components used in ordinary cosmetics, quasi-drugs, pharmaceuticals, etc. as long as the effects of the present invention are not impaired.For example, pH adjusters (such as potassium hydroxide, sodium hydroxide, citric acid, sodium citrate, etc.), fragrances, cooling agents (such as menthol, peppermint oil, camphor, etc.), anti-inflammatory agents (such as salicylic acid, glycyrrhetinic acid, allantoin, indomethacin, felbinac, diclofenac sodium, loxoprofen sodium, etc.), bactericides (such as chlorhexidine gluconate, isopropylmethylphenol, etc.), preservatives (such as parabens (methylparaben, butylparaben, propylparaben, etc.), benzoic acid or its salts, phenoxyethanol, etc.), moisturizing agents (such as hyaluronic acid or its salts, chondroitin sulfate, polyhydric alcohols (such as glycerin, diglycerin, 1,3-butylene glycol, propylene glycol, 1,2-pentanediol, etc.), amino acids (such as L-serine, L-proline, L-hydroxyproline, glycine, etc.), lipiduva, sorbitol, maltitol, etc.), thickening agents (such as polyvinylpyrrolidone, sodium alginate, ethyl cellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, xanthan gum, carrageenan, etc.), extracts of various animals and plants (such as turmeric, cork tree, seaweed, button mushroom, licorice, rosemary, sage, etc.), vitamins (such as retinol palmitate, ascorbic acid, thiamine nitrate, cyanocobalamin, biotin, riboflavin, nicotinamide, etc.), antioxidants (such as dibutylhydroxytoluene, tocopherol, sodium edetate, ascorbic acid, isopropyl gallate, etc.), solubilizing aids (such as various vegetable oils, various animal oils, alkyl glyceryl ethers, hydrocarbons, etc.), oil gelling agents (such as inulin stearate, dextrin palmitate, etc.), metabolic activators, adhesives, antihistamines (such as chlorpheniramine maleate, etc.), local anesthetics (such as procaine, tetracaine, bupivacaine, mepivacaine, chloroprocaine, propalacaine, meprilcaine or their salts, orthocaine, oxethazaine, oxy polyethoxydecane, rohto extract, percamperase, tesitin desitin, etc.), skin protectants (such as collodion, castor oil, etc.), blood circulation promoting components (such as γ-oryzanol, nonyl vanillylamide, benzyl nicotinate, capsaicin, red pepper extract, etc.), mucopolysaccharides (such as glucosamine, hyaluronic acid, heparin-like substances, etc.), etc. These components may be used alone or in combination of two or more. The addition amount of these components is not particularly limited and can be appropriately determined in consideration of the usability and the like. When a pharmacological component is contained, the content thereof may be appropriately set according to the type of the pharmacological component used, the expected effect, and the like.

[0013] The pore visibility improver of the present invention can be used for applications such as cosmetics, quasi-drugs, and pharmaceuticals.

[0014] The pore visibility improver of the present invention is not particularly limited in its form as long as it is a form applicable to the skin. Specific forms include lotions, creams, milky lotions, gels, packs, and the like. The external preparation for skin of the present invention may be a W / O or O / W type emulsion preparation.

[0015] The pore visibility improver of the present invention can be produced by a conventional method according to the dosage form.

Examples

[0016] Examples and comparative examples are shown below to explain the present invention in detail, but the present invention is not limited to the following examples.

[0017] According to the formulations shown in Table 1 below, ectoine, concentrated glycerin, 1,3-butylene glycol, 1,2-pentanediol, citric acid, and sodium citrate were uniformly mixed in purified water to obtain the compositions of the examples and the comparative examples.

[0018]

Table 1

[0019] (Evaluation of improvement in pore visibility) The composition of the example was applied to the entire half face of women in their 20s to 30s twice a day for 4 weeks, and the comparative example was applied to the other half face in the same manner. The evaluation of the improvement of prominent pores was performed by measuring the pore score and the number of pores on the cheek before application and 4 weeks after application using a skin analyzer VISIA Evolution (manufactured by Canfield Scientific Inc.). The pore score was the value calculated by the skin analyzer as the pore score value. In the skin analyzer, pores are detected from the shape and color, and the degree of pore prominence is quantified by an internal analysis device. A smaller pore score means fewer prominent pores. The ratio of the change amount and the difference in the change amount was calculated from the following formula. Change amount = After 4 weeks - Before use Difference in change amount = Change amount of the example - Change amount of the comparative example The results of the pore score are shown in Table 2, and the results of the number of pores are shown in Table 3.

[0020]

Table 2

[0021]

Table 3

[0022] As is clear from the results in Table 2, in all subjects, when the composition of the example containing ectoin was used continuously for 4 weeks, the measured value of the pore score was significantly reduced compared to the case where the composition of the comparative example not containing ectoin was used continuously. Also, from Table 3, it was confirmed that when ectoin was used continuously for 4 weeks, the measured number of pores decreased or the increase was suppressed compared to the comparative example not containing ectoin. Therefore, the effect of improving pore prominence was shown by ectoin.

[0023] (Formulation Example) Hereinafter, formulation examples related to the present invention are shown in Tables 4 to 10.

[0024]

Table 4

[0025]

Table 5

[0026]

Table 6

[0027]

Table 7

[0028]

Table 8

[0029]

Table 9

[0030]

Table 10

Industrial Applicability

[0031] According to the present invention, it has become possible to provide a pore-improving composition containing ectoine.

Claims

1. A pore visibility improver containing ectoine.

2. The pore visibility improver according to Claim 1, which reduces the size of pores.

3. The pore visibility improver according to Claim 1, which reduces the number of prominent pores.

4. A cosmetic or topical skin preparation containing the pore visibility improver according to any one of Claims 1 to 3.

5. The topical skin preparation according to Claim 4, which is a quasi-drug or a pharmaceutical.

6. The cosmetic or topical skin preparation according to Claim 4, wherein the content of ectoine is 1 w / w% or more based on the total amount of the cosmetic or topical skin preparation.

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