Gelatin-containing composition and use of the same

Abstract

To provide a composition in which the dispersion of gelatin and a flavor is improved, even at high temperatures.SOLUTION: A gelatin-containing composition contains hexyl acetate and calcium lactate, the gelatin-containing composition containing at most 10 pts.mass of calcium lactate per 1 pts.mass of the hexyl acetate.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a gelatin-containing composition and its use. [Background technology]

[0002] Gelatin is non-toxic to the human body, inexpensive, and has excellent jelly-forming properties, thickening properties, etc. For these reasons, gelatin is widely used in the fields of medicine, food, etc.

[0003] Gelatin is usually used after swelling with water. For example, Patent Document 1 discloses a method for producing soft candies containing gelatin, in which gelatin that has been previously swollen with water is mixed with other ingredients to produce the soft candy.

[0004] However, since gelatin is used after swelling with water, it is very difficult to mix with oil-based ingredients such as fragrances. Therefore, surfactants are used to facilitate mixing. However, even when surfactants are used, it is difficult to uniformly disperse gelatin and oil-based ingredients, and it becomes even more difficult to maintain uniform dispersion under high temperatures, such as inside a car in summer. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2015-204832 Summary of the Invention [Problem to be solved by the invention]

[0006] An object of the present invention is to provide a composition in which the dispersibility of gelatin and a flavoring agent is improved even at high temperatures. [Means for solving the problem]

[0007] The present inventors have conducted extensive research in light of the above-mentioned problems and have found that by using calcium lactate and hexyl acetate, a flavoring agent, in a specific ratio in a composition containing gelatin, the dispersibility of hexyl acetate in the composition can be improved even at high temperatures.The present invention, which was completed as a result of further research based on this finding, is as follows.

[0008] Item 1. A gelatin-containing composition containing hexyl acetate and calcium lactate, wherein the amount of calcium lactate is 10 parts by mass or less per part by mass of hexyl acetate. Item 2. The gelatin-containing composition according to Item 1, wherein the composition contains 30 parts by mass or less of calcium lactate per 100 parts by mass of gelatin. Item 3. The gelatin-containing composition according to Item 1 or 2, wherein the composition contains 6 parts by mass or less of hexyl acetate per 100 parts by mass of gelatin. Item 4. A method for improving the dispersibility of hexyl acetate in a gelatin-containing composition, comprising: adding hexyl acetate and calcium lactate to the gelatin-containing composition in an amount of 10 parts by mass or less of calcium lactate per 1 part by mass of hexyl acetate. Item 5. The method according to Item 4, which is a method for improving the dispersibility of hexyl acetate in an environment of 50°C or higher. [Effects of the Invention]

[0009] According to the present invention, the dispersibility of hexyl acetate in a composition containing gelatin is improved. It is possible. [Brief explanation of the drawings]

[0010] [Figure 1] FIG. 1 is a diagram that serves as a basis for evaluating dispersibility in test examples. DETAILED DESCRIPTION OF THE INVENTION

[0011] The present invention provides a gelatin-containing composition containing hexyl acetate and calcium lactate, in which the amount of calcium lactate is 10 parts by mass or less per part by mass of hexyl acetate.

[0012] Hexyl acetate has the chemical formula CH 16 It is a known substance represented by O2.

[0013] Calcium lactate is a known substance, and in the present invention, calcium lactate may be anhydrous or hydrated. Calcium lactate exists in L-, D-, and DL-types, and any of these may be used.

[0014] The present gelatin-containing composition contains gelatin. The gelatin may be any gelatin conventionally used in the fields of food, pharmaceuticals, quasi-drugs, etc., and preferably edible gelatin. Examples of gelatin include, but are not limited to, acid- and / or alkali-treated gelatin, chemically modified gelatin such as acylated gelatin, and gelatin hydrolysates, all of which are made from the skin, bones, tendons, ligaments, scales, etc., of pigs, cows, fish, etc. These gelatins may be used alone or in combination of two or more. Gelatin is commercially available, for example, from Nippi Co., Ltd., Nitta Gelatin Co., Ltd., Jellice Co., Ltd., Rousselot, Weishardt, etc.

[0015] The gelatin is not limited to the above, and may be appropriately selected and used using, for example, jelly strength (Bloom value) as an index. Although not limiting the present invention, the jelly strength of gelatin is preferably 50 to 350 g, and more preferably about 80 to 300 g. Gelatin jelly strength is measured in accordance with JIS K-6503 (2001). Specifically, the jelly strength is defined as the load (g) required to press down 4 mm on the surface of a jelly prepared by cooling a 6.67% by mass aqueous gelatin solution at 10°C for 17 hours using a plunger with a diameter of 1 / 2 inch (12.7 mm).

[0016] This gelatin-containing composition contains hexyl acetate and calcium lactate, and the content of calcium lactate is 10 parts by mass or less per part by mass of hexyl acetate. In the present invention, the content of calcium lactate is a value converted to calcium lactate (anhydrous), as shown in the examples below.

[0017] Although not limited thereto, in the present gelatin-containing composition, the amount of calcium lactate per part by mass of hexyl acetate is preferably 0.05 to 10 parts by mass, more preferably 0.5 to 8 parts by mass, and even more preferably 0.7 to 7.5 parts by mass.

[0018] There are no restrictions on the gelatin content in the present gelatin-containing composition, but examples include calcium lactate in an amount of preferably 30 parts by mass or less, more preferably 0.2 to 30 parts by mass, and even more preferably 0.7 to 25 parts by mass per 100 parts by mass of gelatin.

[0019] Furthermore, the content of gelatin in the present gelatin-containing composition is not limited, but examples thereof include an amount of hexyl acetate per 100 parts by mass of gelatin of preferably 6 parts by mass or less, more preferably 0.5 to 6 parts by mass, and even more preferably 1 to 3 parts by mass.

[0020] The content of these components in the present gelatin-containing composition is not limited, but in the composition, acetic acid The total content of hexyl, calcium lactate and gelatin is, for example, preferably 5 to 35% by mass, more preferably 7 to 33% by mass, and even more preferably 8 to 32% by mass.

[0021] The present gelatin-containing composition may further contain any other ingredients, such as pharmaceutically acceptable ingredients, cosmetically acceptable ingredients, and edible ingredients, as needed, within the range in which the effects of the present invention can be obtained. Edible ingredients are preferred as such other ingredients.

[0022] Examples of such other ingredients include water, surfactants, coloring agents, amino acids, vitamins, enzymes, sweeteners, cooling agents, fruit juice, excipients, disintegrants, fluidizing agents, flavoring agents, odorants, suspending agents, wetting agents, solubilizing agents, dispersing agents, buffers, binders, lubricants, plasticizers, penetration enhancers, stabilizers, bulking agents, preservatives, thickeners, pH adjusters, coating agents, absorption enhancers, antioxidants, anti-inflammatory agents, fragrances other than hexyl acetate, waxes, various useful ingredients, etc. These may be used alone or in combination of two or more, and the contents thereof may also be determined appropriately.

[0023] Although not limiting the present invention, examples of surfactants include organic acid monoglycerides, glycerin fatty acid esters, polyglycerin fatty acid esters, propylene glycol fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, lecithin derivatives, polyoxyethylene hydrogenated castor oil, and the like.

[0024] Examples of organic acid monoglycerides include, but are not limited to, acetic acid monoglyceride, lactic acid monoglyceride, citric acid monoglyceride, succinic acid monoglyceride, diacetyltartaric acid monoglyceride, etc.; glycerin fatty acid esters and polyglycerin fatty acid esters include glycerin monofatty acid esters, glycerin difatty acid esters, triglycerin monofatty acid esters, polyglycerin monofatty acid esters, polyglycerin difatty acid esters, etc.; propylene glycol fatty acid esters include propylene glycol monofatty acid esters and propylene glycol difatty acid esters; sorbitan fatty acid esters include sorbitan monofatty acid esters, sorbitan difatty acid esters, sorbitan trifatty acid esters, etc.; and sucrose fatty acid esters include sucrose monofatty acid esters.

[0025] In the surfactant, the fatty acid is preferably, but not limited to, a fatty acid derived from edible animal or plant-derived oils and fats, and is preferably, but not limited to, a saturated or unsaturated fatty acid having 6 to 24 carbon atoms, more specifically, stearic acid, lauric acid, oleic acid, caprylic acid, capric acid, myristic acid, palmitic acid, linoleic acid, linolenic acid, arachidic acid, behenic acid, etc.

[0026] The form of the gelatin-containing composition is not limited, and may be any of liquid, semi-solid (gel (jelly), cream, paste, etc.), solid (powder, granules, etc.), etc.

[0027] The present gelatin-containing composition can be produced according to the desired form by appropriately mixing hexyl acetate, calcium lactate, gelatin, and, if necessary, the other components described above, according to a conventionally known production procedure.

[0028] Although not limiting the present invention, for example, the present gelatin-containing composition may be produced by mixing gelatin and water to prepare a mixture, then mixing hexyl acetate, then mixing calcium lactate, and further mixing other ingredients as necessary during each mixing. Also, although not limiting the present invention, for example, gelatin and water may be mixed to prepare mixture A, and separately hexyl acetate and calcium lactate may be mixed to prepare mixture B, and then mixtures A and B may be mixed to prepare mixture C, and the preparations of each of mixtures A to C may be further mixed. During the preparation, the other ingredients may be further mixed as necessary to produce the present gelatin-containing composition.

[0029] Furthermore, if necessary, the thus obtained mixture containing gelatin, hexyl acetate, and calcium lactate can be molded, dried, etc. to produce the present gelatin-containing composition. The molding may be any desired shape, such as a football, oblong (long ellipse), round (spherical), teardrop, triangle, diamond, sheet, etc., and the molded product may be cut into pieces as needed after molding.

[0030] Examples of such formed products include gummy candy, jelly, bavarois, etc. The present gelatin-containing composition may further be coated with a sugar coating, etc. Coating may also be carried out according to a method conventionally known in the art.

[0031] Furthermore, the gelatin-containing composition may be used as a capsule coating (soft capsules, hard capsules) as a molded product. When the gelatin-containing composition is used as a capsule coating, the contents encapsulated in the coating are not limited and may be appropriately determined depending on the purpose. For example, pharmaceutically acceptable ingredients, cosmetically acceptable ingredients, edible ingredients, etc. may be arbitrarily selected and used, with edible ingredients being preferred. The contents may be encapsulated in the coating according to procedures conventionally known in the art.

[0032] The present gelatin-containing composition may be used either orally or parenterally, and is preferably used orally. The use mode of the present gelatin-containing composition is not limited and may be appropriately determined depending on the purpose. Examples of the use mode when the composition is used orally include food compositions (including beverages, health functional foods (including specified health foods, nutrient functional foods, functional food products, supplements, etc.), health supplements, and foods for the sick), pharmaceutical compositions, quasi-drug compositions, feed compositions, and additives to food compositions, pharmaceutical compositions, quasi-drug compositions, feed, etc. The present gelatin-containing composition may be, for example, swallowed immediately, or may be left in the oral cavity for a certain period of time and then swallowed.

[0033] The subject to which the present gelatin-containing composition is applied (ingested, administered, etc.) is not limited, and examples thereof include humans and non-human mammals. Examples of non-human mammals include guinea pigs, rabbits, dogs, cats, monkeys, chimpanzees, etc.

[0034] According to the present gelatin-containing composition, the dispersibility of hexyl acetate in a gelatin-containing composition can be improved by using 10 parts by mass or less of calcium lactate per part by mass of hexyl acetate. In particular, although the dispersibility of hexyl acetate worsens under high-temperature conditions of 50°C or higher, the present gelatin-containing composition can improve the dispersibility of hexyl acetate in a gelatin-containing composition even under high-temperature conditions of 50°C or higher. From this perspective, according to the present invention, even if a gelatin-containing composition that is solid or semi-solid at room temperature (25°C) becomes liquid under high-temperature conditions of 50°C or higher, its thermal stability is improved, and a decrease in dispersibility in the composition can be suppressed. Therefore, the present invention can provide a gelatin-containing composition with high thermal stability.

[0035] From this, it can be said that the present invention also provides a method for improving the dispersibility of hexyl acetate in a gelatin-containing composition, characterized in that the gelatin-containing composition contains hexyl acetate and calcium lactate in an amount of 10 parts by mass or less of calcium lactate per 1 part by mass of hexyl acetate.

[0036] In this method, gelatin, hexyl acetate, calcium lactate, etc. are the same as those described above. It is explained as follows. [Example]

[0037] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0038] Test Example Preparation of Gelatin-Containing Compositions Gelatin stock was prepared by adding water to gelatin (product name BLK200, manufactured by Nitta Gelatin Co., Ltd.) according to the composition in Table 1, swelling for 5 minutes, and then dissolving the gelatin in a water bath at 80°C. Hexyl acetate was also prepared according to the composition in Table 1, by mixing it with a surfactant (product name Poem K-37V, manufactured by Riken Vitamin Co., Ltd. (organic acid monoglyceride (citric acid monoglyceride)) or polyoxyethylene hydrogenated castor oil (product name Emanon CH-60(K), manufactured by Kao Corporation)) and sonicating it to completely dissolve the hexyl acetate. Water was then added to the resulting solution to disperse it, preparing a hexyl acetate stock. The gelatin stock in which the gelatin had completely dissolved and the hexyl acetate stock were mixed, and the resulting mixture was stirred with a spatula until visually uniform, preparing a gelatin / hexyl acetate stock. Separately, calcium lactate stock was prepared by adding water to calcium lactate (trade name: calcium lactate pentahydrate (L-type calcium lactate), manufactured by Taihei Chemical Industry Co., Ltd.) according to the composition in Table 1 and stirring.

[0039] Next, the gelatin / hexyl acetate stock obtained as described above was added to a screw tube (35 mm x 65 mm), and calcium lactate stock was added and mixed thoroughly. The gelatin / hexyl acetate stock and calcium lactate stock were added to the screw tube in amounts of 20 g in total according to the contents in Table 1. That is, in Table 1, the contents of all components are shown in grams (g). In Example 1, the stocks were mixed to the ratios shown in Table 1 to prepare a gelatin-containing composition, and 20 g of each was placed in a screw tube. In this way, the gelatin-containing compositions of Examples 1 to 5 and Comparative Examples 1 and 2 were prepared.

[0040] Dispersibility evaluation The resulting gelatin-containing composition was placed in a capped screw tube and stored at room temperature (25°C) for 2 hours, and then left to stand in a constant temperature setting of 50°C for one week.

[0041] After leaving it to stand for one week, the gelatin-containing composition in the screw tube was observed from the side, and as shown in Figure 1, three expert panelists visually observed whether the composition was uniformly dispersed and whether the composition was transparent, and evaluated the dispersibility according to the following criteria.

[0042] Judgment criteria ○: Uniform dispersion and transparency △: Uniform dispersion and somewhat transparent ×: Not uniformly dispersed The results are shown in Table 1.

[0043] [Table 1]

[0044] As shown in Comparative Example 1 in Table 1, the composition containing hexyl acetate and gelatin but not calcium lactate was evaluated as × (not uniformly dispersed) for dispersibility. Also, as shown in Comparative Example 2 in Table 1, in the composition containing gelatin, When calcium lactate was added in an amount of 14.16 parts by mass, the dispersibility was also evaluated as ×. Note that none of the compositions in Comparative Examples 1 and 2 were transparent. In contrast, the compositions in Table 1 As shown in Examples 1 to 6, by using calcium lactate in a specific ratio relative to hexyl acetate in a composition containing gelatin, it was possible to improve dispersibility compared to Comparative Examples 1 and 2, and the compositions were transparent or slightly transparent. This demonstrates that by using calcium lactate in a specific ratio relative to hexyl acetate, it is possible to improve the dispersibility of hexyl acetate in a gelatin-containing composition.

Claims

1. A gelatin-containing composition comprising hexyl acetate, calcium lactate, and gelatin, wherein the calcium lactate is 0.7 to 7.5 parts by mass per 1 part by mass of hexyl acetate, the calcium lactate is 0.7 to 25 parts by mass per 100 parts by mass of gelatin, and the hexyl acetate is 1 to 6 parts by mass per 100 parts by mass of gelatin.

2. A method for improving dispersibility of hexyl acetate in a gelatin-containing composition, characterized in that the gelatin-containing composition contains hexyl acetate and calcium lactate in such amounts that 0.7 to 7.5 parts by mass of calcium lactate per 1 part by mass of hexyl acetate, 0.7 to 25 parts by mass of calcium lactate per 100 parts by mass of gelatin, and 1 to 6 parts by mass of hexyl acetate per 100 parts by mass of gelatin.

3. A method for producing a gelatin-containing composition containing hexyl acetate, calcium lactate, and gelatin, comprising the following steps (1) and (2): (1) mixing gelatin and water to prepare mixture 1; (2) mixing the mixture 1 with hexyl acetate and calcium lactate; Here, in the gelatin-containing composition, calcium lactate is 0.7 to 7.5 parts by mass per 1 part by mass of hexyl acetate, calcium lactate is 0.7 to 25 parts by mass per 100 parts by mass of gelatin, and hexyl acetate is 1 to 6 parts by mass per 100 parts by mass of gelatin.

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