Skin-conditioning composition and kit comprising the same

Abstract

To provide a novel skin-conditioning composition which enables removal of skin dirt while making it easier for an active ingredient to penetrate the skin, and a kit comprising the composition.SOLUTION: A skin-conditioning composition of the present invention comprises a keratolytic component. A skin-conditioning and active agent set of the present invention comprises, in separate containers, a skin-active composition comprising a skin-active ingredient and the aforementioned skin-conditioning composition.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a skin conditioning composition and a kit containing the same. [Background technology]

[0002] Cleansing agents for cleaning skin dirt and cosmetics are commercially available, including oil-based liquid cleansing agents, emulsified cream cleansing agents, emulsion cleansing agents, aqueous cleansing agents, and gel cleansing agents.

[0003] In recent years, solid oil-based cleansing agents have also been commercially available. These solid oil-based cleansing agents are also called cleansing balms, and examples thereof include the cleansing agent disclosed in Patent Document 1. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-206974 Summary of the Invention [Problem to be solved by the invention]

[0005] Conventional cleansing agents are intended simply to remove dirt from the skin.

[0006] The present invention aims to provide a novel skin conditioning composition that not only removes dirt from the skin but also facilitates the penetration of active ingredients into the skin, and a kit containing the same. [Means for solving the problem]

[0007] The present invention has the following aspects: <<Aspect 1>> A skin conditioning composition comprising an exfoliating component. <<Aspect 2>> 2. The skin conditioning composition according to aspect 1, wherein the exfoliating ingredient has an acid dissociation constant pKa in water in the range of 2.0 to 6.0. Aspect 3 3. The skin conditioning composition according to claim 2, wherein the exfoliating component has a molecular weight of 1,000 or less. Aspect 4 Aspect 4. The skin conditioning composition according to aspect 3, comprising the exfoliating component in an amount of 0.01% by mass or more and 5.0% by mass or less. Aspect 5 Aspect 5. The skin conditioning composition according to aspect 4, wherein the exfoliating component is a compound having an OH group. Aspect 6 6. The skin conditioning composition of Aspect 5, wherein the exfoliating ingredient is at least one selected from the group consisting of α-hydroxy acid, azelaic acid, mandelic acid, ferulic acid, fulvic acid, PHA (polyhydroxy acid), LHA (lipohydroxy acid), gluconolactone, kojic acid, lactobionic acid, and salicylic acid. Aspect 7 7. The skin conditioning composition of embodiment 6, further comprising an scrubbing material. Aspect 8 The scrubbing material may be selected from the group consisting of kaolin, illite, anhydrous silicic acid, magnesium aluminum silicate, synthetic phlogopite, sericite, talc, boron nitride, mica, cellulose, wheat starch, silk powder, corn starch, aluminum stearate, zinc stearate, magnesium stearate, calcium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate or zinc undecylenate, polyethylene, nylon-6, mannan, silica 8. The skin conditioning composition of Aspect 7, wherein the active ingredient is at least one selected from the group consisting of moss, powdered silicone powder, charcoal, aluminum silicate, hydrated silica, sucrose, almond kernels, apricot seeds, Rubus rubus seeds, olive seeds, poppy seeds, rice flour, coconut shells, hazelnut shells, Walnut kernels, Bambusa arundinacea stems, loofahs, loofah fruits, grape seeds, peach kernels, Rubus rubus seeds, volcanic sand, mother of pearl, sand, sea silt, sea salt, lactose, and glucose. Aspect 9 2. The skin conditioning composition according to claim 1, which is an oily semi-solid composition. Aspect 10 A skin conditioning and active agent set comprising a skin active composition containing a skin active ingredient and the skin conditioning composition according to any one of Aspects 1 to 9, in separate containers. [Effects of the Invention]

[0008] According to the present invention, it is possible to provide a novel skin conditioning composition that not only removes dirt from the skin but also facilitates the penetration of active ingredients into the skin. DETAILED DESCRIPTION OF THE INVENTION

[0009] 《Skin conditioning composition》 The skin conditioning composition contains an exfoliating component. According to the studies of the present inventors, it has been found that not only does it cleanse the skin but also removes the keratin, thereby making it easier for the active ingredient to penetrate the skin.

[0010] The exfoliating component is not particularly limited as long as it can chemically remove keratin from the skin by using a skin conditioning composition like a regular cleanser. However, such exfoliating components can include compounds whose acid dissociation constant pKa in water is in the range of 2.0 to 6.0. This pKa may be, for example, 2.0 or more, 2.5 or more, 3.0 or more, 3.5 or more, 4.0 or more, 4.2 or more, or 4.5 or more, or 6.0 or less, 5.5 or less, 5.0 or less, 4.5 or less, 4.0 or less, or 3.5 or less.

[0011] The molecular weight of the exfoliating component is not particularly limited as long as it can chemically remove keratin from skin by using the skin conditioning composition like a normal cleansing agent.The molecular weight of the exfoliating component may be, for example, a compound having a molecular weight of 1000 or less, and its molecular weight may be, for example, 50 or more, 80 or more, 100 or more, 150 or more, 180 or more, 500 or less, 300 or less, 200 or less, 170 or less, or 150 or less.On the other hand, when a polymeric component such as fulvic acid is used as the exfoliating component, its molecular weight may be 1000 or more, for example, 2000 or more, 5000 or more, 10,000 or more, 100,000 or less, 50,000 or less, or 30,000 or less.

[0012] Such exfoliating components include compounds having an OH group. Examples of compounds having an OH group include compounds having a hydroxyl group, but they may also be compounds having a chemical group containing an OH group, such as a carboxyl group or a phosphate group. The compound having an OH group preferably has two or more OH groups. Furthermore, the exfoliating component is preferably a linear or branched compound having an OH group, and may also be a compound having a cyclic hydrocarbon group. The exfoliating component may also be a compound not containing a heterocyclic group.

[0013] Specific examples of exfoliating ingredients include α-hydroxy acids, azelaic acid, mandelic acid, ferulic acid, fulvic acid, PHA (polyhydroxy acid), LHA (lipohydroxy acid), gluconolactone, kojic acid, lactobionic acid, salicylic acid, etc. These can be used in combination of two or more, and azelaic acid and mandelic acid can be used in combination.

[0014] The skin conditioning composition is not particularly limited in content as long as it contains an effective amount of the exfoliating component. For example, the skin conditioning composition may contain the exfoliating component in an amount of 0.01% by mass or more, 0.05% by mass or more, 0.08% by mass or more, 0.10% by mass or more, or 0.15% by mass or more, or 5.0% by mass or less, 3.0% by mass or less, 1.0% by mass or less, 0.50% by mass or less, 0.30% by mass or less, or 0.20% by mass or less.

[0015] The skin conditioning composition may further comprise a scrubbing material. The scrubbing material is not particularly limited as long as it can physically remove keratin from the skin.

[0016] For example, the scrubbing material may be kaolin, illite, anhydrous silicic acid, magnesium aluminum silicate, synthetic phlogopite, sericite, talc, boron nitride, mica, cellulose (including crystalline cellulose), wheat starch, silk powder, corn starch, aluminum stearate, zinc stearate, magnesium stearate, calcium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate or zinc undecylenate, magnesium sulfate, polyethylene Examples of suitable organic particles include polyethylene, nylon-6, mannan, silica, powdered silicone powder, charcoal, aluminum silicate, hydrated silica, sucrose, plant seed shells (e.g., almond kernels, apricot seeds, rubus rubus seeds, olive seeds, poppy seeds, rice flour, coconut shells, hazelnut shells, Walnut kernels, Bambusa arundinacea stems, loofahs, loofah fruits, grape seeds, peach kernels, and Rubus rubus seeds), volcanic sand, mother of pearl, sand, sea silt, sea salt, lactose, and glucose. Among these, particularly suitable are water-insoluble organic particles such as cellulose, wheat starch, polyethylene, nylon-6, and plant seed shells.

[0017] When the skin conditioning composition is an oily composition, particularly an oily semi-solid, water-soluble particles can be used as the scrubbing agent. For example, water-soluble organic particles such as lactose and glucose can be used as such scrubbing agents. Furthermore, such water-soluble organic particles can be used in combination with the above-mentioned scrubbing agents, particularly water-insoluble organic particles. When water-soluble organic particles and water-insoluble organic particles are used in combination, the mass ratio can be in the range of 1:0.5 to 1:3, or 1:1 to 1:2.

[0018] The skin conditioning composition is not particularly limited in the amount of scrubbing agent contained therein, so long as it contains an effective amount. For example, the skin conditioning composition may contain the scrubbing agent in an amount of 0.01% by mass or more, 0.1% by mass or more, 0.3% by mass or more, 0.5% by mass or more, 1.0% by mass or more, 1.5% by mass or more, or 2.0% by mass or more, or 10% by mass or less, 5.0% by mass or less, 3.0% by mass or less, 1.0% by mass or less, 0.50% by mass or less, 0.30% by mass or less, or 0.20% by mass or less.

[0019] The formulation of the skin conditioning composition is not particularly limited. For example, the skin conditioning composition may be in various forms such as an oily liquid, an oily semi-solid, an emulsion-type cream, a milky lotion, an aqueous liquid, or a gel, and in particular may be in an oily semi-solid form.

[0020] When the skin conditioning composition is oily and semi-solid, it can contain solid oil, liquid oil, and a nonionic surfactant. For example, the skin conditioning composition can contain 1 to 30% by mass of solid oil, 50 to 95% by mass of liquid oil, and 3 to 30% by mass of a nonionic surfactant. When the skin conditioning composition is oily and semi-solid, it can have the same composition and be produced by the same method as a commercially available cleansing balm, except that the above-mentioned exfoliating component and scrubbing material are mixed. An example of a commercially available cleansing balm is DUO (trademark) from Premier Anti-Aging Co., Ltd.

[0021] <Solid oil> The solid oil may be an oil that is solid at room temperature (25°C).

[0022] The content of solid oil in the skin conditioning composition may be 1% by mass or more, 3% by mass or more, 5% by mass or more, 7% by mass or more, or 10% by mass or more, and may be 30% by mass or less, 20% by mass or less, 15% by mass or less, or 10% by mass or less. The content of solid oil in the skin conditioning composition can be, for example, 1% by mass or more and 30% by mass or less, 3% by mass or more and 20% by mass or less, or 5% by mass or more and 15% by mass or less.

[0023] The melting point of the solid oil may be 40°C or higher, 50°C or higher, 60°C or higher, or 70°C or higher, or 120°C or lower, 110°C or lower, 100°C or lower, or 90°C or lower. Here, the melting point of the solid oil can be measured by Melting Point Determination Method 2, a general testing method in the Standards for Quasi-drug Ingredients. The melting point of the solid oil can be, for example, 40°C or higher and 120°C or lower, 50°C or higher and 110°C or lower, or 60°C or higher and 100°C or lower.

[0024] When the content and melting point of the solid oil are within the above ranges, the liquid oil can be solidified uniformly, the storage stability and shape retention are sufficient, and the product can be given an appropriate hardness when used.

[0025] By designing the SP value (solubility parameter) of the solid oil, it is possible to adjust the viscosity and other properties of the skin conditioning composition.

[0026] The SP value is a measure of compatibility between substances. For example, if the difference in SP value between a solid oil and a liquid oil is small, the compatibility is good, and crystals are less likely to grow upon cooling. Because crystals are less likely to grow, the crystal particles become smaller. When small particle size crystals are formed, they can be broken down with less force. Because the crystals can be broken down with less force, a smoother feel can be obtained. In addition, the encapsulation of liquid oil within the crystals improves, improving the stability and moldability of the product. On the other hand, by increasing the difference in SP value between the solid oil and the liquid oil and adjusting the amount of solid oil or liquid oil, an appropriate smooth feel can be imparted to the skin conditioning composition.

[0027] The SP value of the solid oil used may be, for example, 5.0 or more, 6.0 or more, 7.0 or more, 7.5 or more, or 8.0 or more, and may be 12.0 or less, 11.0 or less, 10.0 or less, 9.5 or less, 9.0 or less, or 8.5 or less. The SP value of the liquid oil may be, for example, 5.0 or more and 12.0 or less, 6.0 or more and 10.0 or less, or 7.5 or more and 9.5 or less.

[0028] Here, the SP value is determined by Fedors' estimation method. The definition and calculation of Fedors' estimation method are described in "RF Fedors: Polym. Eng. Sci., 14 [2], 147-154 (1974)." According to Fedors' estimation method, the SP value of each substance can be calculated using the following formula. The difference in SP value between solid oil and liquid oil can be found by determining the SP values ​​of each solid oil and liquid oil and calculating the difference. σ=[ΣECOH / ΣV] 1 / 2 In the formula, σ: solubility parameter, ECOH: cohesive energy (J / mol), V: molar volume (cm 3 / mol).

[0029] Specifically, the solid oil may be any solid oil used in a typical solid oil-based cleanser, such as hydrocarbon waxes such as paraffin wax, polyethylene wax, and Fischer-Tropsch wax, carnauba wax, candelilla wax, rice wax, beeswax (beeswax), hydrogenated jojoba oil, hardened oil, higher alcohol, and silicone wax, and two or more of these may be combined. Oily semi-solid skin conditioning compositions must be heated for a long time during the process of filling them into containers, and hydrocarbon waxes are preferred from the viewpoint of oxidation resistance during heating.

[0030] <Liquid oil> Examples of liquid oils include oils that are fluid at room temperature (25°C) and semi-solid oils with a melting point of less than 50°C or less than 40°C.

[0031] The content of liquid oil in the skin conditioning composition may be 50% by mass or more, 55% by mass or more, 60% by mass or more, 65% by mass or more, or 70% by mass or more, and may be 95% by mass or less, 90% by mass or less, 85% by mass or less, or 80% by mass or less. The content of liquid oil in the skin conditioning composition can be, for example, 50% by mass or more and 95% by mass or less, 55% by mass or more and 90% by mass or less, or 60% by mass or more and 85% by mass or less.

[0032] When the content of the liquid oil is within the above range, the skin conditioning composition can be provided with properties such as easy compatibility with other cosmetics and ease of spreading when applied to the skin.

[0033] The viscosity and other properties of the skin conditioning composition can also be adjusted by designing the SP value (solubility parameter) of the liquid oil.

[0034] The SP value of the liquid oil used may be, for example, 5.0 or more, 6.0 or more, 7.0 or more, 7.5 or more, or 8.0 or more, and may be 12.0 or less, 11.0 or less, 10.0 or less, 9.5 or less, 9.0 or less, or 8.5 or less. The SP value of the liquid oil can be, for example, 5.0 or more and 12.0 or less, 6.0 or more and 10.0 or less, or 7.5 or more and 9.5 or less.

[0035] Furthermore, by designing the difference in SP value (solubility parameter) between the solid oil and the liquid oil, it is possible to adjust the viscosity and other properties of the skin conditioning composition.

[0036] The difference in SP value between solid oil and liquid oil is, for example, 0.01 (J / cm 3 ) 1 / 2 or more, 0.1(J / cm 3 ) 1 / 2 More than 0.3(J / cm 3 ) 1 / 2 or more, 0.5(J / cm 3 ) 1 / 2 or more, or 1.0 (J / cm 3 ) 1 / 2 It can be more than 3.0 (J / cm 3 ) 1 / 2 Below, 2.0(J / cm 3 ) 1 / 2 Below, 1.5(J / cm 3 ) 1 / 2 Below, 1.0(J / cm 3 ) 1 / 2 Below, 0.5(J / cm 3 ) 1 / 2 or less than 0.3 (J / cm 3 ) 1 / 2 The difference in SP value between solid oil and liquid oil is 0.01 to 3.0 (J / cm 3 ) 1 / 2 , 0.1 to 2.0 (J / cm 3 ) 1 / 2 , or 0.3 to 1.0 (J / cm 3 ) 1 / 2 That's fine too.

[0037] The mass ratio of solid oil to liquid oil may be 0.05 or more, 0.10 or more, 0.15 or more, 0.20 or more, or 0.25 or more, and may be 0.50 or less, 0.40 or less, 0.30 or less, 0.25 or less, or 0.20 or less. For example, the mass ratio may be 0.05 or more and 0.50 or less, or 0.10 or more and 0.30 or less.

[0038] Specifically, the liquid oil may be any of the liquid oils used in ordinary solid oily cleansing agents, and may be any of animal oils, vegetable oils, or synthetic oils. For example, tri(caprylic / capric acid)glyceryl, triethylhexanoin, diglyceryl triisostearate, decaglyceryl decaisostearate, cetyl isooctanoate, isopropyl myristate, isopropyl palmitate, cholesterol fatty acid esters, jojoba oil and other esters; hydrocarbons such as volatile isoparaffin, polybutene, polyisobutylene, squalane, petrolatum; oils and fats such as olive oil, castor oil, mink oil, macadamia nut oil and other; fatty acids such as isostearic acid, oleic acid and other; higher alcohols such as oleyl alcohol, isostearyl alcohol and other; silicone oils such as low-polymerization dimethylpolysiloxane, methyl trimethicone, caprylyl trimethicone, fluorine-modified polysiloxane and other; fluorine-based oils such as perfluoropolyether; lanolin, lanolin acetate, lanolin fatty acid isopropyl, lanolin alcohol and other lanolin derivatives; and the like, and two or more of these may be combined.

[0039] <Nonionic surfactants> Nonionic surfactants can provide cleansing benefits to skin conditioning compositions.

[0040] The HLB value of the nonionic surfactant used may be, for example, 3.0 or more, 5.0 or more, 7.0 or more, 8.0 or more, or 9.0 or more, or 15.0 or less, 14.0 or less, 13.0 or less, 12.0 or less, 11.0 or less, or 10.0 or less. The HLB value range of the nonionic surfactant may be, for example, 5.0 or more and 15.0 or less, 7.0 or more and 13.0 or less, or 8.0 or more and 11.0 or less. Here, for example, "the HLB value range of the nonionic surfactant is 5.0 or more and 15.0 or less" means a single nonionic surfactant having an HLB value in the range of 5 to 15, a combination of multiple nonionic surfactants having HLB values ​​in that range, or a combination of multiple nonionic surfactants having two or more different HLB values, resulting in a weighted average HLB value in the range of 5 to 15.

[0041] HLB is an index that shows the balance between hydrophilicity and lipophilicity using a value from 0 to 20, with the closer to 0 the higher the lipophilicity and the closer to 20 the higher the hydrophilicity. There are various known methods for calculating the HLB value, and the values ​​are also listed in catalogs provided by manufacturers. A nonionic surfactant with an appropriate HLB value can be selected according to the polarity of the solid oil and liquid oil.

[0042] The content of the nonionic surfactant in the skin conditioning composition may be 3% by mass or more, 5% by mass or more, 7% by mass or more, 10% by mass or more, or 15% by mass or more, and may be 30% by mass or less, 25% by mass or less, 20% by mass or less, or 15% by mass or less. The content of the nonionic surfactant in the skin conditioning composition can be, for example, 3% by mass or more and 30% by mass or less, 5% by mass or more and 25% by mass or less, or 7% by mass or more and 20% by mass or less.

[0043] When the content of the liquid oil is within the above range, the skin conditioning composition can be provided with properties such as easy compatibility with other cosmetics and ease of spreading when applied to the skin.

[0044] The mass ratio of the nonionic surfactant to the solid oil may be 0.5 or more, 0.8 or more, 1.0 or more, 1.2 or more, or 1.5 or more, and may be 5.0 or less, 4.0 or less, 3.0 or less, 2.5 or less, or 2.0 or less. For example, this mass ratio may be 0.5 or more and 5.0 or less, or 0.80 or more and 3.0 or less.

[0045] The mass ratio of the nonionic surfactant to the liquid oil may be 0.05 or more, 0.10 or more, 0.15 or more, 0.20 or more, or 0.25 or more, or 0.60 or less, 0.50 or less, 0.40 or less, 0.30 or less, or 0.25 or less. For example, this mass ratio may be 0.05 or more and 0.60 or less, or 0.10 or more and 0.30 or less.

[0046] Specifically, the nonionic surfactant may be any of the nonionic surfactants used in ordinary solid oily cleansing agents, such as polyoxyethylene sorbitan fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbit fatty acid esters, polyoxyethylene polyoxypropylene alkyl ethers, polyglycerin fatty acid esters, and polyethylene glycol fatty acid esters, and two or more of these may be used in combination.

[0047] <Other ingredients> The skin conditioning composition may further contain fumed silica. Fumed silica is a fine amorphous silica. Skin conditioning compositions containing fumed silica have a relatively high viscosity during the cooling and solidifying process, which is advantageous because it reduces the likelihood of powder settling.

[0048] The specific surface area of ​​fumed silica is 30m 2 / g or more, 50m 2 / g or more, 100m 2 / g or more, or 150m 2 / g or more, and2 / g or less, 300m 2 / g or less, 200m 2 / g or less, or 150m 2 For example, the specific surface area of ​​fumed silica may be 30 m / g or less. 2 / g or more 400m 2 / g or less, or 100m 2 / g or more 300m 2 / g or less.

[0049] The content of the sprayed silica in the skin conditioning composition may be 0.01% by mass or more, 0.1% by mass or more, 0.2% by mass or more, or 0.5% by mass or more, and may be 5% by mass or less, 3.0% by mass or less, 2.0% by mass or less, or 1.5% by mass or less. For example, the content of the sprayed silica in the skin conditioning composition may be 0.01% by mass or more and 5% by mass or less, or 0.2% by mass or more and 1.5% by mass or less.

[0050] The mass ratio of the atomized silica to the powder in the skin conditioning composition may be 0.1 or more, 0.3 or more, 0.5 or more, 0.8 or more, or 1.0 or more, or 2.0 or less, 1.5 or less, 1.0 or less, 0.8 or less, or 0.5 or less. For example, this mass ratio may be 0.1 or more and 2.0 or less, or 0.3 or more and 1.0 or less.

[0051] The skin conditioning composition of the present invention can contain components used in ordinary cosmetics, such as additives such as water, dyes, oily gelling agents, oil-soluble resins, polyhydric alcohols, lower alcohols, ultraviolet absorbers, ultraviolet scattering agents, moisturizers, fragrances, antioxidants, preservatives, antifoaming agents, and various extracts, within ranges that do not impair the effects of the present invention.

[0052] When the skin conditioning composition is oily and semi-solid, it does not exhibit fluidity at room temperature (25°C) and normal pressure (1 atmosphere), and its shape is not particularly limited. Specific examples of the shape include a stick, rod, plate, and a product cast into a container.

[0053] The oily semi-solid skin conditioning composition can be prepared by a conventional method, for example, by heating all of the raw materials to the melting point or higher, mixing them uniformly, pouring the molten mixture into a predetermined container such as a jar, or into a metal or resin dish, and cooling it to obtain the oily semi-solid skin conditioning composition.

[0054] Skin conditioning and activator set After conditioning the skin condition with the skin conditioning composition as described above, it is preferable to use a skin active composition containing a skin active ingredient to improve the skin condition. Therefore, the present invention also relates to a skin conditioning and active agent set that separately contains a skin active composition containing a skin active ingredient and the above-mentioned skin conditioning composition.

[0055] <Skin active composition> The skin active composition contains a skin active ingredient. Examples of the skin active ingredient include antibacterial ingredients, anti-inflammatory ingredients, anti-inflammatory and analgesic ingredients, vitamins, moisturizing ingredients, whitening ingredients, antioxidant ingredients, anti-aging ingredients, blood circulation promoting ingredients, hair growth ingredients, and antihistamine ingredients. The skin active composition may be a commercially available product as long as it contains such ingredients. For example, The Repair Shot (trademark) from Premier Anti-Aging Co., Ltd., a commercially available cosmetic serum, may be used.

[0056] Examples of antibacterial ingredients include terbinafine and its salts, butenafine and its salts, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, and alkyldiaminoglycine hydrochloride.

[0057] Anti-inflammatory ingredients include comfrey leaf extract, allantoin, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate.

[0058] Examples of the anti-inflammatory and analgesic ingredients include indomethacin, felbinac, ibuprofen, ibuprofen piconol, bufexamac; butyl flufenamate, bendazac, piroxicam, and ketoprofen.

[0059] Examples of vitamins include vitamin A, provitamin A, vitamin B, vitamin C, vitamin D, vitamin E, and vitamin K.

[0060] Examples of vitamin A include retinol, retinol derivatives (retinol acetate, retinol palmitate, etc.), retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d-δ-tocopheryl retinoate, α-tocopheryl retinoate, and β-tocopheryl retinoate.

[0061] Examples of provitamin A include β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, and echinenone.

[0062] Examples of vitamin B include various vitamin B. Examples of vitamin B1 include dibenzoylthiamine, dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, and thiamine triphosphate monophosphate.

[0063] Examples of vitamin B2 include riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, and riboflavin tetranicotinate.

[0064] Examples of vitamin B3 include nicotinic acids such as methyl nicotinate, nicotinic acid, and nicotinamide.

[0065] Examples of vitamin B5 include pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantetheine, D-pantethine, coenzyme A, and pantothenyl ethyl ether.

[0066] Examples of vitamin B6 include pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride.

[0067] Examples of vitamin B7 include biotin and biotin derivatives such as biocytin.

[0068] Examples of vitamin B9 include folic acids such as folic acid and pteroylglutamic acid.

[0069] Examples of vitamin B12 include cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin.

[0070] Examples of vitamin C include ascorbyl stearate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, and ascorbyl glucoside.

[0071] Examples of vitamin D include methylhesperidin, ergocalciferol, and cholecalciferol.

[0072] Examples of vitamin E include α-tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, and tocopherol nicotinate.

[0073] Examples of vitamin K include phylloquinone and falnoquinone.

[0074] Examples of moisturizing ingredients include lavender oil, Salicornia herbacea extract, Imperata cylindrica root extract, collagen, elastin, MPC polymer, trimethylglycine (betaine), hydroxyethyl urea, acrylic acid-acrylamide-dimethyldiallylammonium chloride copolymer, hydrogenated lecithin, hyaluronic acid, sodium hyaluronate, acetylated hyaluronic acid, sodium acetylated hyaluronate, sorbitol, ceramide, peptide, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol, pentaerythritol, diglycerin, polyglycerin, diethylene glycol, triethylene glycol, polyethylene glycol, dipropylene glycol, trehalose, 2-methacryloyloxyethyl phosphorylcholine, and chondroitin sulfate.

[0075] Examples of whitening ingredients include arbutin, hydroquinone, kojic acid, and tranexamic acid.

[0076] Examples of antioxidant components include components derived from plants (e.g., Houttuynia cordata, grapes, ginseng, and comfrey), astaxanthin, proanthocyanidin, tocopherol and its derivatives, ascorbic acid and its derivatives, hesperidin, glucosyl hesperidin, ergothioneine, sodium bisulfite, erythorbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, and hypotaurine.

[0077] Anti-aging ingredients include artemia extract, hydrolyzed soy protein, retinol, retinol acetate, retinol palmitate, and the like.

[0078] Examples of blood circulation-promoting ingredients include ingredients derived from plants (e.g., ginseng, angelica, arnica, ginkgo, fennel, emmeisou, Dutch oak, chamomile, Roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, European hawthorn, European juniper, cnidium rhizome, Swertia japonica, thyme, clove, tangerine peel, angelica acutiloba, peach kernel, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, melissa, yuzu, coix seed, rosemary, rose hip, tangerine peel, angelica acutiloba, spruce, peach, apricot, walnut, or corn), tocopherol nicotinate, glucosyl hesperidin, hesperidin, etc.

[0079] Examples of hair growth ingredients include procyanidins, dipotassium glycyrrhizinate, capronium chloride, cepharanthine, hinokitiol, L-hydroxyproline, acetylhydroxyproline, fucoidan, capsicum tincture, cepharanthine, swerthianin, shinhongginisin, flavonoid steroids, minoxidil, FGF-10, Enmeiso extract, Swertia japonica extract, Mitsuishi Kami extract, Gynostemma pentaphyllum extract, Hypericum perforatum extract, gentian extract, sage extract, peppermint extract, hop extract, Job's tears extract, persimmon leaf extract, Rehmannia root extract, carrot extract, linden extract, Peony extract, and Jew's wort extract.

[0080] Examples of the antihistamine component include ethanolamine compounds such as diphenhydramine, diphenhydramine hydrochloride, and dimenhydrinate; propylamine compounds such as chlorpheniramine maleate; phenothiazine compounds such as promethazine hydrochloride; piperazine compounds such as hydroxyzine; piperidine compounds such as cyproheptadine hydrochloride, as well as epinastine hydrochloride, loratadine, and fexofenadine hydrochloride.

[0081] The above skin active ingredients may be used alone or in combination of two or more in the skin active composition, and the skin active ingredients may be contained in an effective amount corresponding to each ingredient.

[0082] The skin active composition is not particularly limited in content as long as it contains an effective amount of the skin active ingredient, but the skin active composition used in the present invention may contain a much larger amount of the skin active ingredient than is normally used, for example, 1.5 to 10 times, or 2 to 5 times the amount normally used. For example, the skin active composition may contain a skin active ingredient in an amount of 0.01% by weight or more, 0.05% by weight or more, 0.1% by weight or more, 0.3% by weight or more, 0.5% by weight or more, 1.0% by weight or more, 2.0% by weight or more, 3.0% by weight or more, 5.0% by weight or more, 10% by weight or more, 15% by weight or more, 20% by weight or more, or 25% by weight or more, or 50% by weight or less, 30% by weight or less, 20% by weight or less, 15% by weight or less, 10% by weight or less, 5.0% by weight or less, 3.0% by weight or less, 2.0% by weight or less, 1.0% by weight or less, 0.50% by weight or less, 0.30% by weight or less, 0.20% by weight or less, or 0.10% by weight or less.

[0083] The dosage form of the skin active composition is not particularly limited, as is the dosage form of the skin conditioning composition. For example, the skin conditioning composition may be in various forms such as an oily semi-solid, lotion, emulsion, cream, gel, pack / mask, etc. In the case of an oily semi-solid, the components other than the skin active ingredient can refer to the components described above for the oily semi-solid skin conditioning composition.

[0084] <Skin active composition - lotion> The skin active composition may be a lotion. The lotion is used to replenish the stratum corneum with moisture and moisturizing ingredients and to support the physiological functions of the skin. Specific examples of the lotion include cleansing lotions, astringent lotions, softening lotions, and multi-layered lotions, as well as skin lotions, body lotions, hand lotions, and emollient lotions.

[0085] In addition to water and alcohol, the lotion can contain the above-mentioned active ingredients for the skin. For example, the lotion can contain a moisturizing ingredient as one of the active ingredients for the skin, and can also contain other active ingredients for the skin. Furthermore, the lotion can contain emollients (softening agents), solubilizers, buffers, thickeners, etc. depending on its purpose and function.

[0086] The lotion may contain water in an amount of 30% by mass or more, 50% by mass or more, or 70% by mass or more, and 95% by mass or less, 90% by mass or less, or 80% by mass or less. The lotion may also contain alcohol in an amount of 1% by mass or more, 3% by mass or more, or 5% by mass or more, and 20% by mass or less, 15% by mass or less, or 10% by mass or less. Examples of alcohol include ethanol and isopropanol.

[0087] The lotion may contain the moisturizing component as described above as an active ingredient for the skin. The lotion may contain the moisturizing component in an amount of 1% by mass or more, 3% by mass or more, or 5% by mass or more, and 20% by mass or less, 15% by mass or less, or 10% by mass or less.

[0088] As the emollient (softening agent), substances known as emollients (softening agents) for lotions, such as ester oil, vegetable oil, etc. The lotion may contain the emollient (softening agent) in an amount of 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, and 1.0% by mass or less, 0.5% by mass or less, or 0.3% by mass or less.

[0089] The lotion may contain, as a solubilizing agent, a nonionic surfactant such as polyoxyethylene oleyl alcohol ether, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitol fatty acid ester, etc. The lotion may contain the solubilizing agent in an amount of 0.1% by mass or more, 0.5% by mass or more, or 1.0% by mass or more, and 3.0% by mass or less, 2.0% by mass or less, or 1.0% by mass or less.

[0090] The lotion may contain, as a buffer, citric acid, lactic acid, amino acids, etc. These may be blended in appropriate amounts in the lotion to adjust the pH.

[0091] The lotion may contain as a thickener alginate, cellulose derivative, quince seed gum, pectin, pullulan, xanthan gum, veegum, carboxyvinyl polymer, acrylic acid polymer, laponite, etc. These may be blended into the lotion in an appropriate amount to adjust the viscosity, for example, at 0.1% by mass or more, 0.5% by mass or more, or 1.0% by mass or more, and at 3.0% by mass or less, 2.0% by mass or less, or 1.0% by mass or less.

[0092] The toner may further contain other ingredients such as fragrances, preservatives, browning agents, etc., as are known in the art.

[0093] <Skin active composition-emulsion> The skin active composition may be an emulsion. An emulsion is an emulsion with properties intermediate between a lotion and a cream. Except in special cases, emulsions have a smaller amount of oil phase than creams and are fluid emulsions, so they are also known as "liquid creams." Emulsions are either O / W or W / O types, but are generally O / W types, which have a high proportion of aqueous phase and spread thinly when applied to the skin, giving a moist feel.

[0094] The emulsion may contain water, oil, an emulsifier, and the above-mentioned active ingredients for the skin. The emulsion may contain, for example, a moisturizing ingredient as one of the active ingredients for the skin, and may also contain other active ingredients for the skin. In addition, the emulsion may contain a thickener or the like depending on its purpose and function.

[0095] The emulsion may contain 30% or more, 50% or more, or 70% or more by weight of water, and 95% or less, 90% or less, or 80% or less by weight of water.

[0096] The oil may be a liquid oil or a solid oil, such as stearic acid, cetyl alcohol, petrolatum, squalane, cetyl alcohol, beeswax, dimethylpolysiloxane, liquid paraffin, lanolin, etc. The lotion may contain 3% by mass or more, 5% by mass or more, 10% by mass or more, 20% by mass or more, or 30% by mass or more of oil, and 60% by mass or less, 50% by mass or less, 40% by mass or less, 30% by mass or less, or 20% by mass or less of oil.

[0097] The emulsifier may include nonionic surfactants such as polyoxyethylene oleyl alcohol ether, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitol fatty acid ester, etc. The emulsion may contain the emulsifier in an amount of 1.0% by mass or more, 2.0% by mass or more, or 3.0% by mass or more, and 10% by mass or less, 7.0% by mass or less, or 5.0% by mass or less.

[0098] The type and amount of the thickener used in the emulsion can be referenced to the type and amount of the thickener described for the lotion.

[0099] The emulsion may further contain other ingredients such as fragrances, preservatives, antioxidants, neutralizing agents, colorants, etc., as are known in the art.

[0100] <Skin active composition - cream> The skin active composition may be a cream. Creams generally have a larger amount of oil phase than emulsions and are therefore non-fluid emulsions. The purposes of creams, like emulsions, are to cleanse the skin, remove makeup, protect the skin, moisturize and soften it, and promote blood circulation in the skin. More specific examples of creams include cleansing creams, emollient creams, nourishing creams, night creams, base creams, vanishing creams, moisturizing creams, massage creams, cold creams, and lip balms.

[0101] The cream may contain water, oil, an emulsifier, and the above-mentioned active ingredient for skin. The types of oil and emulsifier may refer to those described above for the emulsion.

[0102] The cream may contain water in an amount of 10% by mass or more, 20% by mass or more, 30% by mass or more, or 50% by mass or more, and 80% by mass or less, 50% by mass or less, or 30% by mass or less. The cream may contain oil in an amount of 20% by mass or more, 30% by mass or more, 40% by mass or more, 50% by mass or more, or 60% by mass or more, and 80% by mass or less, 60% by mass or less, 50% by mass or less, 40% by mass or less, or 30% by mass or less. The content of the emulsifier in the cream can be determined by reference to the amount described above for the emulsion.

[0103] The type and amount of the thickener used in the cream can be referenced to the type and amount of the thickener described for the lotion.

[0104] The cream may further contain other ingredients such as chelating agents, fragrances, preservatives, antioxidants, neutralizing agents, colorants, etc., as are known in the art.

[0105] <Skin active composition - gel> The skin active composition may be a gel. Gels have a uniform appearance, are transparent to semi-transparent, and provide a moist feel. Gels include aqueous gels and oily gels; aqueous gels contain a large amount of water, and oily gels contain a large amount of oil.

[0106] The aqueous gel may contain water, a water-soluble polymer, and the above-mentioned active ingredient for skin. The oily gel may contain an oil, an emulsifier, and the above-mentioned active ingredient for skin. The types of oil and emulsifier may refer to those described above for the emulsion.

[0107] The aqueous gel may contain 30% or more, 50% or more, or 70% or more by weight of water, and 95% or less, 90% or less, or 80% or less by weight of water.

[0108] Examples of water-soluble polymers used in aqueous gels include agar, agarose, alginic acids, carrageenan, dextrin, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl alcohol, polyacrylic acid, polymethacrylic acid, carboxyvinyl polymer, (acrylic acid / C10-30 alkyl acrylate) copolymer, xanthan gum, carboxymethyl chitin, chitosan, etc.

[0109] The aqueous gel may contain, for example, 0.1% by mass or more, 0.5% by mass or more, or 1.0% by mass or more of the water-soluble polymer, and 3.0% by mass or less, 2.0% by mass or less, or 1.0% by mass or less.

[0110] The oily gel may contain 30% by mass or more, 50% by mass or more, or 70% by mass or more of oil, and 95% by mass or less, 90% by mass or less, or 80% by mass or less of oil. The content of the emulsifier in the oily gel may refer to the amount described above for the emulsion.

[0111] The gel may further contain other ingredients such as fragrances, preservatives, antioxidants, neutralizing agents, colorants, etc., as are known in the art.

[0112] <Skin active composition - pack cosmetics> The skin active composition may be a pack cosmetic. The pack cosmetic may be a coating type that is applied to the skin to form a film, or may be a patch type that is contained in a substrate such as a nonwoven fabric.

[0113] The pack cosmetic can contain water, alcohol, water-soluble polymer, oil, powder, and the above-mentioned active ingredient for the skin. The pack cosmetic can contain the above-mentioned moisturizing ingredient as the active ingredient for the skin. Here, for the water and alcohol, the types and amounts described for the lotion can be referenced, for the water-soluble polymer, the types and amounts described for the aqueous gel can be referenced, and for the oil, the types and amounts described for the emulsion can be referenced.

[0114] Examples of powders used in pack cosmetics include kaolin, talc, titanium oxide, zinc oxide, spherical cellulose, etc. Pack cosmetics can contain 5% by mass or more, 10% by mass or more, or 15% by mass or more of powder, and 30% by mass or less, 20% by mass or less, or 15% by mass or less of powder.

[0115] The pack cosmetic may further contain other ingredients known in the art, such as fragrances, preservatives, antioxidants, neutralizing agents, coloring agents, and the like.

[0116] <Activator Set> The active agent set may be a set in which the skin conditioning composition and the skin active composition are contained in separate containers, or may be a set in which they are contained separately in the same container. The form of the active agent set is not particularly limited as long as the skin conditioning composition facilitates penetration of the active ingredient into the skin and the skin active composition facilitates delivery of the active ingredient.

[0117] The present invention will be explained in more detail in the following examples, but the present invention is not limited thereto. [Example]

[0118] <Manufacturing example> A commercially available oily semi-solid skin conditioning composition (a so-called cleansing balm) was mixed with 0.1% by mass of azelaic acid as a keratin-exfoliating component and approximately 3% by mass in total of water-insoluble organic particles and water-soluble organic particles as a scrubbing agent, and produced by a conventional method to obtain the skin conditioning composition of Example 1. In addition, a commercially available cleansing balm identical to Example 1 except for containing azelaic acid was produced as the skin conditioning composition of Comparative Example 1.

[0119] <evaluation> A total of eight monitors were asked to apply the skin conditioning composition to the surface of their skin, continue rubbing for a sufficient amount of time, rinse thoroughly with lukewarm water, and then use a commercially available beauty serum.

[0120] <result> When using the serum after using the skin conditioning composition of Example 1, the monitors responded that after rubbing their hands back and forth around the application area 10 times, their fingers no longer felt slippery and the serum felt more absorbed into their skin than when using the skin conditioning composition of Comparative Example 1.

Claims

1. A skin conditioning composition comprising an exfoliating component.

2. 2. The skin conditioning composition according to claim 1, wherein the acid dissociation constant pKa of the exfoliating component in water is in the range of 2.0 to 6.

0.

3. The skin conditioning composition according to claim 2 , wherein the exfoliating component has a molecular weight of 1,000 or less.

4. The skin conditioning composition according to claim 3 , comprising the exfoliating component in an amount of 0.01% by mass or more and 5.0% by mass or less.

5. The skin conditioning composition according to claim 4 , wherein the exfoliating component is a compound having an OH group.

6. 6. The skin conditioning composition according to claim 5, wherein the exfoliating component is at least one selected from the group consisting of α-hydroxy acid, azelaic acid, mandelic acid, ferulic acid, fulvic acid, PHA (polyhydroxy acid), LHA (lipohydroxy acid), gluconolactone, kojic acid, lactobionic acid, and salicylic acid.

7. The skin conditioning composition of claim 6 further comprising an exfoliating material.

8. The scrubbing material may be selected from the group consisting of kaolin, illite, anhydrous silicic acid, magnesium aluminum silicate, synthetic phlogopite, sericite, talc, boron nitride, mica, cellulose, wheat starch, silk powder, corn starch, aluminum stearate, zinc stearate, magnesium stearate, calcium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, zinc undecylenate, polyethylene, nylon-6, mannan, silica 8. The skin conditioning composition according to claim 7, wherein the active ingredient is at least one selected from the group consisting of moss, powdered silicone powder, charcoal, aluminum silicate, hydrated silica, sucrose, almond kernels, apricot seeds, Rubus rubus seeds, olive seeds, poppy seeds, rice flour, coconut shells, hazelnut shells, Walnut kernels, Bambusa arundinacea stems, loofahs, loofah fruits, grape seeds, peach kernels, Rubus rubus seeds, volcanic sand, mother of pearl, sand, sea silt, sea salt, lactose, and glucose.

9. The skin conditioning composition according to claim 1 , which is an oily semi-solid composition.

10. A skin conditioning and active agent set comprising a skin active composition containing a skin active ingredient and a skin conditioning composition according to any one of claims 1 to 9 in separate containers.