Peracetic acid composition for cleaning medical devices, and method for producing same

Abstract

To provide a medical device sterilizing and cleaning composition that has high peroxide stability, meets sewage disposal standards when discarded, and has improved protein-removing ability.SOLUTION: A sterilizing and cleaning composition comprising 0.001-15 mass% of peracetic acid, 0.01-70 mass% of acetic acid and / or a salt thereof, 0.001-25 mass% of hydrogen peroxide, and water, further comprising an additive, wherein the pH value of the composition is 4.0-10.0.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a peracetic acid composition for sterilization and cleaning suitable for sterilizing and cleaning medical equipment, and a method for producing the same. Regarding the method. [Background technology]

[0002] Conventionally, acidic or alkaline chemicals have been used to sterilize and clean medical equipment, and peroxygen water Solutions are one of them. However, because acidic and alkaline chemicals are used, The wastewater was discharged without meeting the sewage discharge standards, damaging the concrete sewer pipes. Damage to sewer pipes not only prevents water from being discharged into the sewer system, but also causes damage to roads. This may cause a sinkhole, so immediate action is required. In January 2019, the Tokyo Metropolitan Sewerage Bureau issued a warning regarding dialysis wastewater and sewer pipes. The Tokyo Metropolitan Government Bureau of Sewerage sets the sewage discharge standard as a hydrogen ion concentration (pH) exceeding 5. It is required to keep it within the range of less than 9.

[0003] As a peracetic acid composition for sterilization and cleaning of medical equipment, acidic peracetic acid water is used. solution (Patent Document 1), an acidic oxidizing agent-containing composition for inhibiting aluminum corrosion (Patent Document 2), Alkaline disinfectant and cleaning preparations (Patent Document 3) are known. The composition of the present invention does not necessarily meet the sewage discharge standards for wastewater. There is still a need for cleaning agents that do not damage water pipes. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2010-184868 [Patent Document 2] WO2010 / 095231 publication [Patent Document 3] Special Publication No. 2016-532634 Summary of the Invention [Problem to be solved by the invention]

[0005] Highly stable peroxide, and wastewater that meets sewage standards. For sterilizing and cleaning medical equipment. There is a need for compositions. [Means for solving the problem]

[0006] As a result of extensive research, the present inventors have found that the addition of an additive can stabilize peroxides. Highly effective, meets sewage discharge standards, and has improved protein removal capabilities for sterilizing medical equipment. and a cleaning composition.

[0007] That is, the present invention includes the following embodiments.

[0008] <1> Peracetic acid is 0.001 to 15% by mass, acetic acid and / or a salt thereof is 0.01 to 70% by mass, containing 0.001 to 25 mass% of hydrogen peroxide and water, Contains additives, A disinfecting and cleaning composition, the pH value of which is 4.0 to 10.0. <2> The additives include polyoxyethylene lauryl ether acetic acid and / or a salt thereof, a phosphorus-based ammonium salt, The stabilizer is at least one selected from the group consisting of stabilizers, carboxylic acid stabilizers, and stannates. <1> The disinfecting and cleaning composition according to claim 1. <3> <1> or the additive is polyoxyethylene lauryl ether acetic acid and / or a salt thereof; <2> The disinfecting and cleaning composition according to claim 1. <4> The additive is a phosphorus-based stabilizer. <1> ~ <3> For sterilization and cleaning according to any one of the composition. <5> The additive is a carboxylic acid-based stabilizer. <1> ~ <4> Sterilization and Cleaning compositions. <6> The additives include polyoxyethylene lauryl ether acetic acid and / or a salt thereof, a phosphorus-based ammonium salt, stabilizers, and carboxylic acid stabilizers, <1> or <2> The disinfecting and cleaning composition according to . <7> The phosphorus stabilizer is 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). or its salts, diethylenetriaminepentamethylenephosphonic acid (DTPP) or its salts Contains either <6> The disinfecting and cleaning composition according to claim 1. <8> The carboxylic acid stabilizer is ethylenediaminetetraacetic acid (EDTA) or a salt thereof, diethyl containing either lentriamine pentaacetic acid (DTPA) or its salts, <6> Sterilization and and cleaning compositions. <9> The phosphorus stabilizer is 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). or a salt thereof, The carboxylic acid stabilizer is ethylenediaminetetraacetic acid (EDTA) or a salt thereof. <6> The disinfecting and cleaning composition according to claim 1. <10> 0.001 to 5 mass % of the polyoxyethylene lauryl ether acetic acid and / or salt thereof %include, <6> ~ <9> The disinfecting and cleaning composition according to any one of the preceding claims. <11> The phosphorus-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass, and the carboxylic acid-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass. Contains a stabilizer in an amount of 0.0001% by mass or more but less than 0.5% by mass, <6> ~ <9> Either The disinfecting and cleaning composition described above. <12> The pH value of the composition is 5.0 to 9.0. <1> ~ <11> A combination of any one of Finished product. <13> It includes a mixing step of mixing at least the following components: <1> ~ <12> Any of the following Method for producing the composition. (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) acetate <14> It includes a mixing step of mixing at least the following components: <1> ~ <12> Any of the following Method for producing the composition. (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) Alkali <15> After mixing the additive, acetic acid, and alkali, add hydrogen peroxide solution at 30 to 50°C. , <14> The manufacturing method described in <16> <1> ~ <12> a composition according to any one of the preceding claims; additional water A diluted disinfecting and cleaning composition comprising: <17> Peracetic acid is 0.001 to 1.5 mass%, acetic acid and / or a salt thereof is 0.01 to 7 mass%, containing 0.001 to 2.5 mass% of hydrogen peroxide and water, Contains additives, The pH value of the composition is 4.0 to 10.0. <16> Diluted disinfectant and cleaning agent described in Interpretation composition. <18> <1> ~ <12> or a composition according to any one of <16> or <17> The rare A method for sterilizing and cleaning medical instruments using a dilution composition. <19> The sterilization and cleaning method of the medical instrument is a dipping method, a spraying method, a coating method, a liquid passing method, a circulation method, a sealing method, Selected from the entry method, <20> The sterilization and cleaning method described in <20> The medical device is a dialysis device. <18> or <19> The sterilization and cleaning method described in Law. [Effects of the Invention]

[0009] According to the present invention, by adding an additive, the stability of the peroxide is high and the wastewater is sewage-proof. We provide a composition for disinfecting and cleaning medical devices that meets the exclusion criteria and has improved protein removal ability. The composition of the present invention has a pH value that satisfies the sewage exclusion standard, so that after use, The waste liquid can be discharged without the need for neutralization treatment. DETAILED DESCRIPTION OF THE INVENTION

[0010] 1. Disinfecting and cleaning compositions In one embodiment of the present invention, the disinfecting and cleaning composition comprises peracetic acid, hydrogen peroxide, acetic acid and and / or its salts, and water, as well as additives.

[0011] In one embodiment of the present invention, the disinfecting and cleaning composition has a pH value of 4.0 to 10. In one embodiment of the present invention, the pH value of the disinfecting and cleaning composition may be, for example, 0. For example, 4.0, 4.5, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5. 7, 5.8, 5.9, 6.0, 6.5, 7.0, 7.5, 8.0,8.5, 9.0,9. 5, 10.0, etc., but are not limited to these values. The pH value of the disinfecting and cleaning composition is, for example, 4.0 to 10.0, 4.0 to 9.5, 4.0~9.0, 4.0~8.5, 4.0~8.0, 4.0~7.5, 4.0~7.0, In one embodiment of the present invention, the pH may be 4.0 to 6.5, or 4.0 to 6.0. The pH value of the cleaning composition is 4.5 to 10.0, 4.5 to 9.5, 4.5 to 9.0, 4.5 ~8.5, 4.5~8.0, 4.5~7.5, 4.5~7.0, 4.5~6.5, 4.5 In one embodiment of the present invention, the pH value of the disinfecting and cleaning composition may be , 5.0~10.0, 5.0~9.5, 5.0~9.0, 5.0~8.5, 5.0~8. It may be 0, 5.0 to 7.5, 5.0 to 7.0, 5.0 to 6.5, or 5.0 to 6.0. In one embodiment of the present invention, the pH value of the disinfecting and cleaning composition is 5.1 to 10.0, 5 .1~9.5, 5.1~9.0, 5.1~8.5, 5.1~8.0, 5.1~7.5, 5 In one embodiment of the present invention, The pH value of the disinfecting and cleaning composition is 5.2 to 10.0, 5.2 to 9.5, 5.2 to 10.0, 9.0, 5.2~8.5, 5.2~8.0, 5.2~7.5, 5.2~7.0, 5.2~ In one embodiment of the present invention, the sterilization and cleaning set The pH values ​​of the products are 5.3-10.0, 5.3-9.5, 5.3-9.0, and 5.3-8.5. , 5.3~8.0, 5.3~7.5, 5.3~7.0, 5.3~6.5, 5.3~6.0 In one embodiment of the present invention, the pH value of the disinfecting and cleaning composition may be 5.4 ~10.0, 5.4~9.5, 5.4~9.0, 5.4~8.5, 5.4~8.0, 5. The range of the viscosity of the polymerizable compound of the present invention may be 4 to 7.5, 5.4 to 7.0, 5.4 to 6.5, or 5.4 to 6.0. In one embodiment, the pH value of the disinfecting and cleaning composition is 5.5 to 10.0, 5.5 to 9. .5, 5.5~9.0, 5.5~8.5, 5.5~8.0, 5.5~7.5, 5.5~7 In a preferred embodiment of the present invention, In a more preferred embodiment of the present invention, the pH value of the disinfecting and cleaning composition is 5.0 to 9.0. In an embodiment, the pH value of the disinfecting and cleaning composition is greater than 5.0. In a preferred embodiment, the pH value of the disinfecting and cleaning composition is greater than 5 and less than or equal to 10. In another more preferred embodiment, the pH value of the disinfecting and cleaning composition is greater than 5 and less than or equal to 9. be.

[0012] In one embodiment of the present invention, the disinfecting and cleaning composition contains 0.001 to 15 mass % peracetic acid. % by weight, acetic acid and / or its salts at 0.01 to 70% by weight, and hydrogen peroxide at 0.001 to 25% by weight. % by volume, and water, Contains additives, The pH value of the composition may be 4.0 to 10.0.

[0013] In one embodiment of the present invention, the additives included in the disinfecting and cleaning composition are polyoxyethylene terephthalate. Ethylene lauryl ether acetic acid and / or its salt, phosphorus-based stabilizer, carboxylic acid-based stabilizer, and stannates.

[0014] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a polyoxyethylene The composition may comprise ethylene lauryl ether acetic acid and / or a salt thereof.

[0015] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a phosphorus-based stabilizer It may include:

[0016] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a carboxylic acid-based It may contain a stabilizer.

[0017] In one embodiment of the present invention, the disinfecting and cleaning composition contains stannate as an additive. It may be something like this.

[0018] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a phosphorus-based stabilizer and a carboxylic acid stabilizer. The composition may further comprise a stannate as an additive.

[0019] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a polyoxyethylene Ethylene lauryl ether acetic acid and / or its salt, phosphorus-based stabilizer, and carboxylic acid-based stabilizer In this embodiment, the disinfecting and cleaning composition may comprise as an additive and may further comprise a stannate.

[0020] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a polyoxyethylene It may contain ethylene lauryl ether acetic acid and / or its salts, and a phosphorus-based stabilizer. In this embodiment, the disinfecting and cleaning composition further comprises stannate as an additive. It may include.

[0021] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a polyoxyethylene It contains ethylene lauryl ether acetic acid and / or its salt, and a carboxylic acid stabilizer. In this embodiment, the disinfecting and cleaning composition may contain stannate as an additive. It may further include:

[0022] In one embodiment of the present invention, the disinfecting and cleaning composition contains, as an additive, a polyoxyethylene The composition may include ethylene lauryl ether acetate and / or its salts, and stannate.

[0023] In one embodiment of the present invention, the disinfecting and cleaning composition contains 0.000% stannate. It may be contained at a concentration of 1 to 5% by mass.

[0024] In another embodiment of the present invention, the disinfecting and cleaning composition contains peracetic acid in an amount of 0.001 to 15 % by mass, acetic acid and / or its salts at 0.01 to 70% by mass, and hydrogen peroxide at 0.001 to 25% by mass. % by mass, and water, Contains stannate as an additive, The pH value of the composition may be 4.0 to 10.0.

[0025] In one embodiment of the present invention, the disinfecting and cleaning composition contains a phosphorus-based stabilizer and calcium carbonate. In the disinfecting and cleaning composition of the present invention, the phosphorus-based stabilizer may further be contained. The concentration of the stabilizer may be 0.0001% by mass or more and less than 0.5% by mass, and the carboxylic acid The concentration of the system stabilizer may be greater than or equal to 0.0001% by weight and less than 0.5% by weight.

[0026] Each component will be described below.

[0027] (1) Additives The disinfecting and cleaning composition of the present invention comprises peracetic acid, hydrogen peroxide, acetic acid and / or salts thereof, and The composition contains water and may further contain additives. By adding these additives, the hydrogen peroxide The stability of the disinfectant and cleaning composition is improved, and the pH value of the disinfectant and cleaning composition is adjusted to 4.0 to 10.0. Furthermore, the disinfecting and cleaning composition of the present invention can be adjusted to have a pH value within the above range. By adjusting the surface area, excellent protein removal power can also be achieved. The disinfecting and cleaning composition contains, as an additive, polyoxyethylene lauryl ether acetic acid and and / or its salt, a phosphorus-based stabilizer, a carboxylic acid-based stabilizer, and a stannate The composition may contain one or more of the above.

[0028] <Polyoxyethylene lauryl ether acetic acid and / or its salt> The disinfecting and cleaning composition of the present invention contains, as an additive, polyoxyethylene lauryl ether. The disinfecting and cleaning composition of the present invention may contain poly(aminopropyl acetic acid) and / or a salt thereof as an additive. The composition may contain ethylenedioxyethylene lauryl ether acetic acid and / or a salt thereof alone, and may contain phosphorus-based stabilizers, carboxylic acid stabilizers, and stannates. The polyoxyethylene compounds that may be used in the disinfecting and cleaning compositions of the present invention may also be included. Polyoxyethylene lauryl ether acetic acid and / or polyoxyethylene lauryl ether acetic acid are represented by the following general formula: The salt of uryl ether acetic acid may be, for example, a sodium salt, a potassium salt, etc. Polyoxyethylene lauryl ether acetic acid and / or a salt thereof is preferred. and polyoxyethylene lauryl ether acetate. R1-(O-R2)nO-R3-COOH (wherein R1 is a lauryl group, R2 is an ethylene group, and R3 is a methylene group) , n represents a number from 1 to 30.)

[0029] In a preferred embodiment, n may be 2 to 20. , n is, for example, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9 It may be, but is not limited to, 0.5, 10, 11, 12, 13, 14, 15. In a more preferred embodiment, n is 4.5 or 10.

[0030] The polyoxyethylene lauryl ether used in the disinfecting and cleaning composition of the present invention The molecular weight of the diacetic acid and / or salt thereof may be 300 to 1200. In the above, the molecular weight of polyoxyethylene lauryl ether acetic acid and / or its salt is 40 It ranges from 0 to 1000.

[0031] In the disinfecting and cleaning composition of the present invention, polyoxyethylene lauryl ether acetic acid and The concentration of the polyoxyethylene laurate and / or its salt may be 0.001 to 5% by mass. The concentration of the methyl ether acetic acid and / or its salt may be preferably 0.01 to 2% by mass. It may be 0.01 to 1 mass % or more preferably 0.01 to 1 mass %.

[0032] <Phosphorus-based stabilizer> The disinfecting and cleaning compositions of the present invention may include a phosphorus-based stabilizer as an additive. The agent stabilizes hydrogen peroxide and adjusts the pH value of the disinfecting and cleaning composition to the above range. Any composition that can be prepared by the method of the present invention can be used. may contain a phosphorus-based stabilizer alone as an additive, and polyoxyethylene lauryl ether tert-butylacetic acid and / or its salt, a carboxylic acid stabilizer, and a stannate. The disinfecting and cleaning compositions of the present invention may contain one or more of the following in combination. Examples of the phosphorus-based stabilizer that can be used include pyrophosphoric acid or a salt thereof, phosphoric acid or a salt thereof, 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or its salts, diethylene Triaminepentamethylenephosphonic acid (DTPP) or its salts, nitrilotrismethylene phosphonic acid or a salt thereof, 2-phosphonobutane-1,2,4-tricarboxylic acid or a salt thereof, and ethylenediaminetetramethylenephosphonic acid or its salts, but are not limited to these. In one embodiment of the present invention, the phosphorus stabilizer is 1-hydroxyethylidene In another embodiment of the present invention, the compound may be hydroxypropyl-1,1-diphosphonic acid (HEDP) or a salt thereof. In this case, the phosphorus stabilizer is diethylenetriaminepentamethylenephosphonic acid (DTPP). or a salt thereof. In yet another embodiment of the present invention, the phosphorus-based stabilizer is pyrophosphate. In a preferred embodiment of the present invention, the phosphorus-based stabilizer is It may be 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) or a salt thereof. .

[0033] In the disinfecting and cleaning composition of the present invention, the concentration of the phosphorus-based stabilizer is 0.0001% by mass. It may be 0.5 mass% or more and less than 0.5 mass%, and preferably 0.0001 to 0.30 mass%. It is preferably 0.0001 to 0.20 mass%, more preferably 0. It may be 0.001 to 0.10 mass %.

[0034] <Carboxylic acid stabilizer> The disinfecting and cleaning compositions of the present invention may include a carboxylic acid stabilizer as an additive. The carboxylic acid stabilizer stabilizes hydrogen peroxide and adjusts the pH value of the disinfecting and cleaning composition. Any substance can be used as long as it can be adjusted to the above range. The cleaning composition may contain a carboxylic acid stabilizer alone as an additive, and a polyoxyethylene stabilizer may be used. The group consisting of ethylene lauryl ether acetic acid and / or its salts, phosphorus-based stabilizers, and stannates The disinfecting and cleaning composition of the present invention may contain one or more selected from the following in combination. Examples of the carboxylic acid stabilizer that can be used in the present invention include ethylenediaminetetraacetic acid. (EDTA) or its salts, diethylenetriaminepentaacetic acid (DTPA) or its salts, picolinic acid dipicolinic acid or its salts, nitrilotriacetic acid or its salts, N-(2-hydroxybenzoic acid) (hydroxyethyl)ethylenediamine-N,N',N"-triacetic acid or its salts, triethylenediamine Tramin-N,N,N',N",N"',N"'-hexaacetic acid or its salt, 1,3-propane Diamine-N,N,N',N'-tetraacetic acid, 1,3-diamino-2-propanol-N,N ,N',N'-tetraacetic acid, N-(2-hydroxyethyl)iminodiacetic acid or its salt, N,N -Di(2-hydroxyethyl)glycine or its salts, glycol ether diamine tetraacetic acid and (S,S)-ethylenediamine-N,N'-disuccinic acid or a salt thereof. In one embodiment of the present invention, the carboxylic acid stabilizer is ethylenediamine. In another embodiment of the present invention, the hydroxybenzoate may be dibenzodiaminetetraacetic acid (EDTA) or a salt thereof. The carboxylic acid stabilizer is diethylenetriaminepentaacetic acid (DTPA) or a salt thereof. In a preferred embodiment of the present invention, the carboxylic acid stabilizer is ethylenediaminetetraacetic acid. It may be acetic acid (EDTA) or a salt thereof.

[0035] In the disinfecting and cleaning composition of the present invention, the concentration of the carboxylic acid stabilizer is 0.0001 It may be 0.0001 to 0.30% by mass or more and less than 0.5% by mass, and preferably 0.0001 to 0.30% by mass. It may be 0.0001 to 0.20 mass %, more preferably 0.0001 to 0.20 mass %, and even more preferably may be 0.0001 to 0.10 mass %.

[0036] In one embodiment of the present invention, the disinfecting and cleaning composition comprises: The phosphorus-based stabilizer is 1-hydroxyethylidene-1,1-diphosphonic acid (HED P) or its salt, diethylenetriaminepentamethylenephosphonic acid (DTPP) or its salt containing either a salt, The carboxylic acid stabilizer may be ethylenediaminetetraacetic acid (EDTA) or a salt thereof, di It may contain ethylenetriaminepentaacetic acid (DTPA) or any of its salts.

[0037] In one embodiment of the present invention, the disinfecting and cleaning composition comprises: The phosphorus-based stabilizer is 1-hydroxyethylidene-1,1-diphosphonic acid (HED P) or a salt thereof, The carboxylic acid stabilizer contains ethylenediaminetetraacetic acid (EDTA) or a salt thereof. It can be seen.

[0038] In one embodiment of the present invention, the disinfecting and cleaning composition contains 0.00% of the phosphorus-based stabilizer. 0.1% by mass or more and less than 0.5% by mass, and the carboxylic acid stabilizer is 0.0001% by mass or more The content may be less than 0.5% by mass.

[0039] In one embodiment of the present invention, the disinfecting and cleaning composition contains 0.00% of the phosphorus-based stabilizer. 0.01 to 0.30 mass %, and the carboxylic acid stabilizer is 0.0001 to 0.30 mass % It may contain % by mass.

[0040] In one embodiment of the present invention, the disinfecting and cleaning composition contains 0.00% of the phosphorus-based stabilizer. 0.01 to 0.20 mass %, and the carboxylic acid stabilizer is 0.0001 to 0.20 mass % It may contain % by mass.

[0041] In one embodiment of the present invention, the disinfecting and cleaning composition contains 0.00% of the phosphorus-based stabilizer. 0.01 to 0.10 mass %, and the carboxylic acid stabilizer is 0.0001 to 0.10 It may contain % by mass.

[0042] <Stannate> The disinfecting and cleaning composition of the present invention comprises peracetic acid, hydrogen peroxide, acetic acid and / or salts thereof, and It contains water and may contain stannate as an additive. By adding stannate, the water peroxide The stability of the element is improved, and the pH value of the disinfecting and cleaning composition is adjusted to 4.0 to 10.0. The disinfecting and cleaning composition of the present invention can be prepared by using stannate alone as an additive. may contain polyoxyethylene lauryl ether acetate and / or its salts, phosphorus-based stabilizers and one or more additives selected from the group consisting of a stabilizer and a carboxylic acid stabilizer. In the present invention, the stannate may be, for example, sodium stannate, potassium stannate, or the like. The preferred materials of the present invention include, but are not limited to, strontium stannate, strontium stannate, and the like. In one embodiment, the stannate may be sodium stannate.

[0043] In the disinfecting and cleaning composition of the present invention, the concentration of the stannate is 0.0001 to 5 mass %. The amount may be 0.0001 to 1 mass %, preferably 0.0001 to 1 mass %, more preferably 0.0001 to 1 mass %. It may be 0.5% by mass, and even more preferably 0.0001 to 0.2% by mass.

[0044] (2) Other ingredients <Hydrogen peroxide> The disinfecting and cleaning composition of the present invention contains hydrogen peroxide. In the composition, hydrogen peroxide itself has sterilizing and cleaning properties, so the entire composition It not only contributes to enhancing the disinfecting and cleaning effects, but also produces a sufficient amount of excess water through an equilibrium reaction with acetic acid. It contributes to the production and maintenance of acetic acid (stability in aqueous solution). The combination with hydrogen can further enhance the sterilizing and cleaning effects of the composition of the present invention. do.

[0045] The concentration of hydrogen peroxide in the sterilizing and cleaning composition of the present invention is 0.001 to 25 mass %. %, preferably 0.005 to 20 mass %, more preferably 0.01 to 15 mass %. The concentration of hydrogen peroxide may be 0.02 to 10% by mass, and more preferably 0.02 to 10% by mass. If the temperature is too high, the amount of peracetic acid produced by the equilibrium reaction with acetic acid will be insufficient, and the sterilization and cleaning effects of the present invention will not be achieved. On the other hand, if the concentration of hydrogen peroxide is too high, the above effect may not be fully exerted. It may not increase the risk of fire and may even pose a safety problem.

[0046] <Acetic acid and / or its salts> The acetic acid used in the disinfecting and cleaning compositions of the present invention is a compound commonly used in the art. As for the salt of acetic acid, it is possible to use one that is alkaline when dissolved in water. There is no particular limitation on the acetate salt, and examples thereof include sodium acetate, potassium acetate, and lithium acetate. ammonium acetate, beryllium acetate, magnesium acetate, aluminum acetate, calcium acetate, Vidium, strontium acetate, cesium acetate, barium acetate, ammonium acetate, etc. Examples include:

[0047] The concentration of acetic acid and / or a salt thereof in the disinfecting and cleaning composition of the present invention is 0.01 to It may be 70% by mass, preferably 0.05 to 60% by mass, more preferably It may be 0.1 to 55% by mass, and even more preferably 0.2 to 50% by mass.

[0048] In the disinfecting and cleaning composition of the present invention, the concentration of acetic acid and / or its salts is In one embodiment of the present invention, the concentration of acetic acid and / or its The salt concentration is 3.5 to 250 times, 3.5 to 150 times, 3.5 to 100 times, or 3.5 to 100 times the concentration of peracetic acid. 5~250x, 5~150x, 5~100x, 10~250x, 10~150x, 10~ In a preferred embodiment of the present invention, acetic acid and / or its The salt concentration is 10 to 250 times, 10 to 150 times, or 10 to 100 times the concentration of peracetic acid. If the concentration of acetic acid and / or its salts is as above, the amount of acetic acid adhering to the object to be sterilized and cleaned will be reduced. This can sufficiently remove calcium scale such as calcium carbonate.

[0049] <Peracetic acid> The peracetic acid used in the disinfecting and cleaning compositions of the present invention is a compound commonly used in the art. Anything that is commonly used can be used.

[0050] The concentration of peracetic acid in the disinfecting and cleaning composition of the present invention is 0.001 to 15% by mass. In one embodiment of the present invention, the concentration of peracetic acid in the disinfecting and cleaning composition The concentration is, for example, 0.001 mass%, 0.005 mass%, 0.01 mass%, 0.1 mass%, 0.3 mass%, 0.4 mass%, 0.5 mass%, 0.6 mass%, 1.0 mass%, 3.0 mass% %, 4.0 mass%, 5.0 mass%, 10 mass%, 15 mass%, but are not limited to these. In one embodiment of the present invention, the concentration of peracetic acid in the disinfecting and cleaning composition is The concentration is, for example, 0.001 to 15 mass%, 0.001 to 10 mass%, 0.001 to 5 mass%. %, 0.001~3% by mass, 0.005~15% by mass, 0.005~10% by mass, 0.0 05~5% by mass, 0.005~3% by mass, 0.01~15% by mass, 0.01~10% by mass , 0.01~5% by mass, 0.01~3% by mass, 0.1~15% by mass, 0.1~10% by mass , 0.1~5% by mass, 0.1~3% by mass, 0.3~15% by mass, 0.3~10% by mass, 0 .3~5% by mass, 0.3~3% by mass, 0.4~15% by mass, 0.4~10% by mass, 0.4 ~5% by mass, 0.4~3% by mass, 0.5~15% by mass, 0.5~10% by mass, 0.5~5 Mass%, 0.5~3 mass%, 0.6~15 mass%, 0.6~10 mass%, 0.6~5 mass% %, 0.6~3% by mass, 1.0~15% by mass, 1.0~10% by mass, 1.0~5% by mass, In one embodiment of the present invention, the sterilization and cleaning composition may contain 1.0 to 3 mass % of the sterilization and cleaning composition. The concentration of peracetic acid in the composition may be preferably 0.001 to 10% by mass, more preferably The content is preferably 0.005 to 5% by mass, and even more preferably 0.01 to 3% by mass. That's fine.

[0051] <Other ingredients> The disinfecting and cleaning composition of the present invention may further contain, as needed, a general disinfecting and cleaning agent. Additives used in formulations, such as surfactants, thickeners, fragrances, colorants, hydrolytic enzymes, etc. In the disinfecting and cleaning composition of the present invention, hydrogen peroxide, acetic acid, and and / or its salts, peracetic acid, and the remainder other than stabilizers and other additives added as needed. , mainly water.

[0052] The disinfecting and cleaning compositions of the present invention can be used as is without dilution or optionally The diluent can be diluted to a concentration of 100 mg / kg to prepare a diluted composition for disinfection and cleaning. Water is used as a diluent. Examples of water used as a diluent include pure water, ultrapure water, distilled water, purified water, Water for injection, tap water, etc. can be used. The dilution ratio is set to 100%. The dilution ratio is not particularly limited as long as it is a concentration that can achieve the desired antibacterial and cleaning effect. However, it is preferably 1 to 10,000 times, and more preferably 1 to 1,000 times.

[0053] 3. Diluted compositions for disinfection and cleaning The diluted disinfecting and cleaning composition of the present invention contains peracetic acid, acetic acid and / or its salts, hydrogen peroxide, and water, and additives, and further includes additional water as a diluent. As mentioned above.

[0054] In one embodiment of the present invention, the diluted disinfectant and cleaning composition is a disinfectant and cleaning composition as described above. The composition contains the above ingredients and additional water.

[0055] The diluted sterilizing and cleaning composition of the present invention can be prepared by diluting the above-mentioned sterilizing and cleaning composition with water. As described above, the dilution ratio is set to the level required for the disinfecting and cleaning diluted composition. The dilution ratio is not particularly limited as long as it is a concentration that can achieve the desired antibacterial and cleaning effect. However, it is preferably 1 to 10,000 times, and more preferably 1 to 1,000 times.

[0056] In one embodiment of the present invention, the diluted disinfecting and cleaning composition has a peracetic acid concentration of 0.0 It may be 0.01 to 1.5 mass%, preferably 0.001 to 1.0 mass%, more preferably is 0.005 to 0.5 mass%, and even more preferably 0.005 to 0.3 mass%. good.

[0057] In one embodiment of the present invention, the diluted disinfecting and cleaning composition contains acetic acid and / or its salts. The concentration may be 0.01 to 7% by mass, preferably 0.05 to 6% by mass, more preferably The content may be preferably 0.1 to 5.5 mass %, and even more preferably 0.2 to 5 mass %.

[0058] In one embodiment of the present invention, the diluted disinfecting and cleaning composition has a hydrogen peroxide concentration of 0. It may be 0.001 to 2.5% by weight, preferably 0.005 to 2% by weight, more preferably may be 0.01 to 1.5 mass %, and even more preferably 0.02 to 1.0 mass %. .

[0059] In one embodiment of the present invention, the diluted composition for disinfection and cleaning contains peracetic acid in an amount of 0.001 to 1 0.5% by mass, acetic acid and / or its salts at 0.01 to 7% by mass, hydrogen peroxide at 0.001 to 2 0.5% by weight, and water, Contains additives, The pH value of the composition may be 4.0 to 10.0.

[0060] In one embodiment of the present invention, the diluted disinfecting and cleaning composition contains, as an additive, polyoxyethylene. Diethylene lauryl ether acetic acid and / or its salt, phosphorus-based stabilizer, carboxylic acid-based stabilizer and stannates.

[0061] In one embodiment of the present invention, polyoxyethylene terephthalate may be included in the diluted disinfecting and cleaning composition. The concentration of ethylene lauryl ether acetic acid and / or its salt is 0.00001 to 0.1% by mass. It may be 0.00005 to 0.05 mass %, preferably 0.00005 to 0.05 mass %, more preferably It may be 0.0001 to 0.03 mass%, and even more preferably 0.0001 to 0. It may be 0.01% by mass.

[0062] In one embodiment of the present invention, the phosphorus-based stabilizer that can be included in the diluted disinfecting and cleaning composition is The concentration may be 0.0001 to 0.05% by mass, preferably 0.0001 to 0.0 3% by mass, more preferably 0.0001 to 0.02% by mass, and even more preferably 0.0 It may be 0.001 to 0.01% by mass.

[0063] In one embodiment of the present invention, a carboxylic acid-based sanitizing agent that can be included in the diluted disinfecting and cleaning composition is The concentration of the stabilizer may be 0.0001 to 0.05% by mass, preferably 0.0001 to 0.05% by mass. 0.03% by mass, more preferably 0.0001 to 0.02% by mass, and even more preferably It may be 0.0001 to 0.01% by mass.

[0064] In one embodiment of the present invention, the concentration of stannate that may be included in the diluted disinfecting and cleaning composition is may be 0.0001 to 0.5% by mass, preferably 0.0001 to 0.1% by mass , more preferably 0.0001 to 0.05 mass%, and even more preferably 0.0001 to It may be 0.02% by mass.

[0065] 4. Method for producing disinfectant and cleaning composition and diluted disinfectant and cleaning composition In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises the steps of: Minutes: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) acetate In this manufacturing method, no heat of neutralization is generated, and the manufacturing process can be carried out easily. When the aqueous solution reaches equilibrium, peracetic acid also exists in the solution. However, peracetic acid may be added in the mixing step. The components may be mixed in any order, and the disinfecting and cleaning composition of the present invention can be used in a variety of ways. In a substance, each component in the mixture is in equilibrium.

[0066] The acetate may be any acetate that is alkaline when dissolved in water, such as Sodium acetate, potassium acetate, lithium acetate, beryllium acetate, magnesium acetate, vinegar Aluminum acetate, calcium acetate, rubidium acetate, strontium acetate, cesium acetate Examples of the usable acetic acid include, but are not limited to, barium acetate, and ammonium acetate. In one embodiment, the acetate salt may be sodium acetate. In some embodiments, the acetate salt may be potassium acetate.

[0067] In one embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises the steps of: Minutes: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) Alkali In this manufacturing method, heat of neutralization is generated and the mixture is transferred to the liquid phase. The reaction rate can be increased and the reaction can be accelerated. Peracetic acid may also be present in the mixture, but peracetic acid may be added in the mixing step. Each component is as described above. The components may be mixed in any order. In the disinfecting and cleaning compositions of the invention, the ingredients are mixed in equilibrium.

[0068] Examples of the alkali include sodium hydroxide, potassium hydroxide, and lithium hydroxide. Beryllium hydroxide, magnesium hydroxide, aluminum hydroxide, calcium hydroxide, hydroxide Rubidium hydroxide, strontium hydroxide, cesium hydroxide, barium hydroxide, ammonia, etc. In one embodiment of the present invention, an alkali metal ion can be used. In another embodiment of the present invention, the alkali is sodium hydroxide. It may be potassium oxide.

[0069] The above manufacturing method using alkali involves mixing the additive, acetic acid and alkali, and then heating for 30 minutes. In this manufacturing method, the hydrogen peroxide solution is mixed at a temperature of about 50°C. To achieve this, the additive, acetic acid, and alkali are mixed together to generate heat from neutralization, and the resulting mixture is then mixed with the acetic acid and alkali. Hydrogen peroxide solution can be mixed at 0-50℃, which increases the translation speed and This can accelerate the response.

[0070] In one embodiment of the present invention, a method for producing a disinfectant and cleaning composition includes the following steps (A) and (B): B: Step (A) At least (i) an additive, (ii) hydrogen peroxide solution and acetic acid, and (i ii) Acetate or alkali and mixing the above components; Step (B) A step of leaving the aqueous solution (a) obtained in step (A) standing for one day or more. The aqueous solution (a) obtained in step (A) may be dissolved in water in step (B). Upon standing, the aqueous solution reaches an equilibrium state. The temperature at which the mixture is allowed to stand in step (B) is preferably 20 to 60°C, more preferably 20 to 60°C. The temperature is 0 to 50° C. In addition, the time for leaving the mixture to stand in the step (B) is preferably one day or more. For example, it may be 2 days or more, 3 days or more, 5 days or more, 10 days or more, 30 days or more, etc. In embodiments where an alkali is used, the reaction is accelerated by the generation of heat of neutralization, as described above. It is possible.

[0071] In yet another embodiment of the present invention, a method for preparing a disinfecting and cleaning composition comprises the steps of: (C)~(E): Step (C) Mixing at least (ii) hydrogen peroxide solution and acetic acid, and (i) additives and Step (D) is a step of leaving the aqueous solution (c) obtained in Step (C) to stand for one day or more; Step (E) the aqueous solution (d) obtained in Step (D), (iii) an acetate or alkali, and mixing water. The aqueous solution (c) obtained in step (C) may be allowed to stand. The temperature at which the aqueous solution is left standing in step (D) is preferably 20 to 6 0°C, more preferably 20 to 50°C. The time is preferably 1 day or more, for example 2 days or more, 3 days or more, 5 days or more, or 10 days or more. After that, the equilibrium state of the aqueous solution (d) is added with acetate or The alkali and water are mixed.

[0072] In one embodiment of the present invention, a method for preparing a diluted disinfectant and cleaning composition includes at least the following steps: Ingredients: (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) Acetate or alkali a mixing step of mixing the above ingredients; A dilution step of diluting the obtained mixture When the aqueous solution reaches an equilibrium state, the aqueous solution contains peracetic acid. An acid will also be present, and peracetic acid may be added during the mixing step. The above is as described above. The dilution step may include mixing the mixture obtained in the mixing step with water. The water used as a diluent may be, for example, pure water, ultrapure water, distilled water, purified water, water for injection, tap water, etc. etc. can be used.

[0073] 5. Sterilization and cleaning method using the sterilization and cleaning composition The sterilizing and cleaning composition or the diluted sterilizing and cleaning composition of the present invention can be diluted. It can be used as it is or diluted to any desired concentration and used in, for example, medical devices, beverages, and food. Food containers, industrial wastewater, cooling water for air conditioning equipment, clothing, cooking utensils, tableware, bathrooms, kitchens, washing machine drums, wind It can be used to sterilize and clean pots, furniture, pets, etc.

[0074] In one embodiment of the present invention, the disinfecting and cleaning composition or the disinfecting and cleaning dilution Methods for sterilizing and cleaning medical instruments using the compositions are provided. The method for sterilizing and cleaning the medical instrument is a dipping method, a spraying method, a coating method, a liquid passing method, In the method for sterilizing and cleaning a medical instrument of the present invention, the method may be selected from a circulation method and an encapsulation method. The amount of the sterilizing and cleaning composition or diluted sterilizing and cleaning composition to be used and the time of sterilizing and cleaning The time period should be adjusted according to the type and amount of microorganisms, the concentration of the cleaning composition or the diluted composition for disinfection and cleaning, etc. Therefore, it can be selected appropriately.

[0075] In the sterilization and cleaning method of the present invention, the medical instruments include dialysis instruments, endoscope instruments, etc. Instruments, surgical instruments, obstetric and urological instruments, anesthesia equipment, artificial respiration equipment, dental instruments In the sterilization and cleaning method of the present invention, The medical device is preferably a dialysis device. [Example]

[0076] Examples of the present invention are given below. However, these examples are not intended to be limiting of the scope of the present invention. are illustrative and are not intended to limit the scope of the invention.

[0077] <Method for measuring hydrogen peroxide concentration in disinfecting and cleaning compositions> In the present invention, the hydrogen peroxide concentration of the disinfecting and cleaning composition (peracetic acid composition) is determined by the oxidation-reduction Specifically, approximately 0.1 g of sample was precisely weighed and placed in a 250 mL Erlenmeyer flask. The test solution was prepared by adding 100 mL of pure water and 10 mL of 1.8 mol / L sulfuric acid. Add a few drops of ferroin TS to the solution and titrate with 0.1 mol / L cerium (IV) sulfate solution. The hydrogen peroxide concentration was calculated.

[0078] <Method for measuring acetic acid and peracetic acid concentrations in disinfecting and cleaning compositions> In the present invention, the acetic acid concentration and peracetic acid concentration of the sterilizing and cleaning composition (peracetic acid composition) are This was done by neutralization titration. Specifically, approximately 0.1 g of the disinfectant and cleaning composition sample was precisely weighed. The test solution was prepared by adding 50 mL of pure water to a 100 mL beaker. Titrate with 0.5 vol / L sodium hydroxide solution, and calculate the acetic acid concentration from the amount added at the first inflection point. The peracetic acid concentration was calculated from the amount added from the first inflection point to the second inflection point.

[0079] <Total Peroxide Concentration (TPO) in Disinfecting and Cleaning Compositions> In the present invention, the total peroxide concentration of the disinfecting and cleaning composition (peracetic acid composition) is iodine It was carried out by a reduction titration method. Specifically, about 0.1 g of the sample was precisely weighed and placed in a 250 mL Erlenmeyer flask. After adding 100 mL of pure water and 10 mL of 1.8 mol / L sulfuric acid, 10 mL of a 10 mass% potassium iodide solution and a few drops of a 1 mass% ammonium molybdate solution were added to prepare a test solution. To this test solution, 0.1 mol / L sodium thiosulfate solution was added dropwise, and starch was used as an indicator. The end point was determined when the blue-violet color of the solution disappeared and became colorless, and the liberated iodine was quantified. From the amount of iodine, the total peroxide concentration in terms of hydrogen peroxide was calculated.

[0080] <Stability of the sterilizing and cleaning composition> The stability of the sterilizing and cleaning composition (peracetic acid composition) of the present invention was calculated by taking the total peroxide concentration (TPO) at the time of preparation as 100 and using the ratio of the total peroxide concentration at the time of measurement.

[0081] <pH measurement> The pH of the cleaning composition and the diluted solution of the cleaning composition was measured using a pH meter (LAQUA, D-71S, manufactured by Horiba, Ltd.).

[0082] <Preparation of spore suspension>[[]] The standard strain of Bacillus cereus (manufactured by Microbiologics, product name: Bacillus cereus ATCC10876) was spread on MYP agar (manufactured by AZONE Corporation, product name: Salmon Spec medium) and cultured at 35 °C for 7 days. Sterilized distilled water was added to this agar medium, and the cells were scraped off with a conical rod and collected, and washed with sterilized distilled water by centrifugation. The bacteria that survived after heating at 80 °C for 10 minutes to obtain only the spore form were used as a spore suspension.

[0083] <Sterilization test> The cleaning composition was appropriately diluted with sterilized distilled water to prepare a sample solution. To 4.5 mL of each sample solution, 1​​​​​​​​​ Add 0.5 mL of % by mass albumin solution and 50 μL of spore suspension, and incubate at 25°C for 120 minutes. After the reaction, the solution was diluted 10 times with 0.1 mol / L sterilized sodium thiosulfate solution and A medium for detecting Bacillus reus (manufactured by Nissui Pharmaceutical Co., Ltd., product name: Compact Dry X-BC) was used. The spores were cultured at 35°C for 48 hours and the viable cell count was measured. The viable cell count at time was recorded.

[0084] <Protein removal test> The cleaning composition was diluted appropriately with pure water to prepare 50 g of sample liquid. After soaking the dicator (Nescos IC W·I, manufactured by Sakura Color Products Co., Ltd.) for 60 minutes, Wash with 10 mL of pure water and dry at room temperature. The staining of the cleaning evaluation indicator was measured using a difference meter (NF555, manufactured by Nippon Denshoku Industries Co., Ltd.). The color difference (ΔEab) from the unwashed white area was measured. The color difference of the evaluation indicator was set at 100, and the color difference after washing was calculated as a ratio.

[0085] <Calcium carbonate dissolution test> The cleaning composition was appropriately diluted with pure water to prepare 50 g of sample solutions. The dissolved weight of calcium carbonate was taken as the dissolved amount. Ta.

[0086] Example 1 22.0 g of pure water and 60% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid (H EDP ​​(manufactured by Italmatch Japan Co., Ltd., product name: Day Quest 2010) 0.17 g, disodium ethylenediaminetetraacetic acid dihydrate (EDTA·2Na·2H2O, M 0.11 g of glacial acetic acid (manufactured by Showa Denko K.K.) 18.0 g of 99% pure acetic acid (product name: acetic acid), sodium acetate trihydrate (Fujifilm Wako 45.6 g of 45% by mass hydrogen peroxide solution (Mitsubishi Gas Chemical Company, 14.2 g of SER45 (product name) was mixed in a PE container. The total peroxide concentration at the time of mixing was After mixing, it was aged for 7 days at 25°C, and the content was 5.6% by mass of hydrogen peroxide and 17% by mass of acetic acid. 0.1% by mass, peracetic acid 1.1% by mass, 1-hydroxyethylidene-1,1-diphosphonic acid ( HEDP) 0.1% by mass, disodium ethylenediaminetetraacetic acid (EDTA·2Na) 0 A peracetic acid composition having a pH of 5.1 and a concentration of 0.1% by mass was obtained, which is used for cleaning dialysis equipment. The peracetic acid composition was stored at 25°C for 14 days after preparation and the total peroxide concentration (TPO The stability was calculated from the results shown in Table 1.

[0087] <Examples 2 to 14 and Comparative Examples 1 to 6> The same procedure as in Example 1 was carried out except that the additives listed in Table 1 were used. The disinfectant and cleaning composition was obtained with a total peroxide concentration of 1000 mg / kg. The TPO (Total Peroxide Oxide) was measured and the stability was calculated. The results are shown in Table 1. The following DTPP, sodium stannate·3H2O, and DTPA were used. Diethylenetriaminepentamethylenephosphonic acid (DTPP, manufactured by Mitsubishi Gas Chemical Company, Inc.) , refined products) Sodium stannate trihydrate (Na stannate·3H2O, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) ) Diethylenetriaminepentaacetic acid (DTPA, manufactured by Dojindo Laboratories, Ltd.)

[0088] <Examples 15 to 20> The same procedure as in Example 1 was carried out except that the composition was as shown in Table 2 and the mixture was aged at 50°C for 1 day. The disinfectant and cleaning compositions were obtained with the concentrations shown in Table 2. After mixing, the total peroxide content was measured after aging at 50°C for 1 day and at 25°C for 20 days. The concentration (TPO) was measured and the stability was calculated, and the results are shown in Table 2.

[0089] <Examples 21 to 22, Comparative Examples 7 to 12> The same procedure as in Example 1 was carried out except that the composition was as shown in Table 3 and the mixture was aged at 25°C for 21 days. In this manner, disinfectant and cleaning compositions with the concentrations shown in Table 3 were obtained. After mixing, the total peroxide concentration (TPO) was measured at 25°C for 21 days to determine the stability. The results are shown in Table 3. The values ​​of 50% phytic acid and N The following aOH was used: 50% by mass phytic acid solution (50% phytic acid, Fujifilm Wako Pure Chemical Industries, Ltd.) Sodium hydroxide (NaOH, Fujifilm Wako Pure Chemical Industries, Ltd.)

[0090] <Examples 23 to 25, Comparative Examples 13 to 14> The same procedure as in Example 21 was carried out except that the formulation was as shown in Table 4, and the concentrations shown in Table 4 were obtained. The disinfecting and cleaning composition was prepared by 25°C. After 21 days, the total peroxide concentration (TPO) was measured and the stability was calculated. The results are shown in Table 4. The pyrophosphates used in the table are as follows: Pyrophosphate (manufactured by Junsei Chemical Co., Ltd., product name: diphosphate)

[0091] <Comparative Examples 15 to 21> The same procedure as in Example 21 was repeated except that the formulation was as shown in Table 5 and the mixture was aged at 25°C for 11 days. In the same manner, disinfectant and cleaning compositions with the concentrations shown in Table 5 were obtained. After mixing, the total peroxide concentration (TPO) was measured at 25°C for 21 days. The results are shown in Table 5. The concentrations of dipicolinic acid and ED The following TMP was used: Dipicolinic acid (Fujifilm Wako Pure Chemical Industries, Ltd.) Ethylenediaminetetramethylenephosphonic acid (EDTMP, manufactured by Tokyo Chemical Industry Co., Ltd.)

[0092] [Table 1]

[0093] [Table 2-1]

[0094] [Table 2-2]

[0095] [Table 3-1]

[0096] [Table 3-2]

[0097] [Table 4]

[0098] [Table 5]

[0099] <Examples 26 to 29> The results of a study on the method for producing the sterilizing and cleaning composition of the present invention are shown below as examples. In Examples 26 and 28, which used alkali, the results were higher than those in Examples 27 and 29, which used acetate. In comparison, an increase in the reaction rate due to the heat of neutralization was observed.

[0100] [Table 6]

[0101] <Example 101> 28.2 g of pure water and 60% by mass of 1-hydroxyethylidene-1,1-diphosphonic acid (H EDP ​​(Italmatch Japan Co., Ltd., product name: Day Quest 2010) 0.02 g, disodium ethylenediaminetetraacetic acid dihydrate (EDTA·2Na·2H2O, M 0.01 g of polyoxyethylene (4.5 ) Lauryl ether acetate (Kao Corporation, product name: Kao Akipo RLM-45) 0. 01g, 8.0g of 99% acetic acid (manufactured by Showa Denko K.K., product name: 99% pure acetic acid), 14.2 g of 45% hydrogen peroxide (manufactured by Mitsubishi Gas Chemical Company, Inc., product name: SER45) 49.6 g of sodium acetate trihydrate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) in a PE container After mixing, the mixture was left to age at 25°C for 7 days, resulting in a mixture of 5.8% by mass of hydrogen peroxide and 7% by mass of acetic acid. 0.6% by mass, peracetic acid 0.4% by mass, sodium acetate 29.9% by mass, 1-hydroxyethyl 0.01% by mass of ethylenediaminetetraacetic acid, 0.01% by mass of disodium ethylenediaminetetraacetic acid 0.01% by mass, polyoxyethylene (4.5) lauryl ether acetic acid 0.01% by mass A cleaning composition was obtained. The resulting cleaning composition was analyzed for total peroxide content 14 days after preparation. The concentration of the substance was measured and the stability was calculated. pH measurement, sterilization test, protein removal test, calcium carbonate A dissolution test was conducted, and the number of bacteria, protein removal rate, and amount of dissolved calcium carbonate were calculated after 120 minutes. The results are shown in Tables 7 and 8. The stability shown in Table 7 was evaluated as follows: . A: 95% or more B: 80% or more C: Less than 80%

[0102] <Example 102, Comparative Example 101> The same procedure as in Example 101 was carried out except that the formulation was as shown in Table 7. The disinfecting and cleaning composition was prepared in a concentration of 1. After 4 days, the total peroxide concentration was measured and the stability was calculated. The number of bacteria, protein removal rate, and calcium carbonate dissolution rate were measured after 120 minutes. The results are shown in Tables 7 and 8. The stability shown in Table 7 was Evaluation was carried out in the same manner as in Example 101. The pyrophosphates shown in the table were as follows: Ta. Pyrophosphate (manufactured by Junsei Chemical Co., Ltd., product name: diphosphate)

[0103] [Table 7]

[0104] [Table 8]

[0105] As described above, according to the present invention, the stability of the peroxide is improved by adding an additive. , effluent meets sewage discharge standards and has improved protein removal ability, for sterilizing and cleaning medical equipment It has been shown that a composition for use can be provided.

Claims

1. Peracetic acid is 0.001 to 15% by mass, acetic acid and / or a salt thereof is 0.01 to 70% by mass, containing 0.001 to 25 mass% hydrogen peroxide and water, Contains additives, A disinfecting and cleaning composition, wherein the pH value of the composition is 4.0 to 10.

0.

2. The additives include polyoxyethylene lauryl ether acetic acid and / or a salt thereof, a phosphorus-based ammonium salt, The stabilizer is at least one selected from the group consisting of a stabilizer, a carboxylic acid stabilizer, and a stannate salt. The disinfecting and cleaning composition of claim 1.

3. The additive is polyoxyethylene lauryl ether acetic acid and / or a salt thereof. Item 3. The disinfecting and cleaning composition according to item 1 or 2.

4. The disinfecting and cleaning method according to any one of claims 1 to 3, wherein the additive is a phosphorus-based stabilizer. Composition for use.

5. The sterilization and disinfection method according to any one of claims 1 to 4, wherein the additive is a carboxylic acid-based stabilizer. and cleaning compositions.

6. The additives include polyoxyethylene lauryl ether acetic acid and / or a salt thereof, a phosphorus-based ammonium salt, The disinfecting and cleaning composition according to claim 1 or 2, wherein the stabilizer is a carboxylic acid-based stabilizer.

7. The phosphorus-based stabilizer is 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). or its salt, diethylenetriaminepentamethylenephosphonic acid (DTPP) or its salt The disinfecting and cleaning composition according to claim 6, comprising any one of:

8. The carboxylic acid stabilizer is ethylenediaminetetraacetic acid (EDTA) or a salt thereof, diethyl 7. The disinfectant of claim 6, comprising lentriamine pentaacetic acid (DTPA) or any of its salts. and cleaning compositions.

9. The phosphorus-based stabilizer is 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). or a salt thereof, the carboxylic acid stabilizer is ethylenediaminetetraacetic acid (EDTA) or a salt thereof; The disinfecting and cleaning composition of claim 6.

10. 0.001 to 5 mass % of the polyoxyethylene lauryl ether acetic acid and / or its salt %. The disinfecting and cleaning composition according to any one of claims 6 to 9.

11. The phosphorus-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass, and the carboxylic acid-based stabilizer is contained in an amount of 0.0001% by mass or more and less than 0.5% by mass. The composition according to any one of claims 6 to 9, comprising a stabilizer in an amount of 0.0001% by mass or more and less than 0.5% by mass. A disinfecting and cleaning composition as described above.

12. The composition according to any one of claims 1 to 11, wherein the pH value of the composition is 5.0 to 9.

0. composition.

13. The method according to any one of claims 1 to 12, comprising a mixing step of mixing at least the following components: A method for producing the composition. (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) acetate

14. The method according to any one of claims 1 to 12, comprising a mixing step of mixing at least the following components: A method for producing the composition. (i) Additives (ii) Hydrogen peroxide and acetic acid (iii) alkali

15. After mixing the additive, acetic acid, and alkali, add hydrogen peroxide solution at 30 to 50°C. The method of claim 14.

16. A composition according to any one of claims 1 to 12, additional water A diluted disinfecting and cleaning composition comprising:

17. Peracetic acid is 0.001 to 1.5% by mass, acetic acid and / or a salt thereof is 0.01 to 7% by mass, containing 0.001 to 2.5 mass% hydrogen peroxide and water, Contains additives, 17. The disinfectant and cleaning composition according to claim 16, wherein the pH value of the composition is 4.0 to 10.

0. Diluted composition.

18. The composition according to any one of claims 1 to 12 or the diluted composition according to claim 16 or 17. A method for sterilizing and cleaning medical instruments using a dilution composition.

19. The sterilization and cleaning method of the medical instrument is a dipping method, a spraying method, a coating method, a liquid passing method, a circulation method, a sealing method, 19. The sterilization and cleaning method according to claim 18, wherein the sterilization and cleaning method is selected from the group consisting of a sterilization method, ...

20. 20. The sterilization and cleaning method according to claim 18 or 19, wherein the medical instrument is a dialysis instrument. 。

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