Method for evaluating water permeability of oral dry matter removal agent, and oral dry matter removal agent

Abstract

To provide a method for appropriately evaluating water permeability in an oral application agent, and further provide an oral dry matter removal agent having extensibility, adhesiveness and moisture permeability.SOLUTION: It has been found that performance of an oral application agent to penetrate moisture into a target object against gravity can be evaluated based on a diameter of a moisture penetration circle measured by the overlay filter paper method, and that an oral dry matter removal agent composed of a jelly-like composition containing pectin with a specified DE value has suitable extensibility and adhesiveness, and can penetrate a larger amount of moisture into a target object more quickly and continuously than oral moisturizers using conventional thickeners.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a method for evaluating the water permeability of an oral dry matter remover and to an oral dry matter remover. [Background technology]

[0002] As our society ages, the number of patients receiving tube feeding is increasing. Furthermore, the number of patients with swallowing disorders due to chemotherapy in cancer treatment, cerebral infarction, and cerebral hemorrhage is also on the rise. These patients suffer from severe dry mouth, and symptoms include the drying and sticking of oral epithelial membranes to the oral cavity, and the spread of tongue coating. These symptoms not only reduce saliva secretion and swallowing function, but can also lead to aspiration pneumonia.

[0003] Dentists and dental hygienists provide professional oral care by removing dry oral epithelial membranes and tongue coating, but with the recent increase in the number of patients, further product development is required.

[0004] Patent Document 1 describes an oral cavity moisturizing composition that contains agar, at least one thickener selected from the group consisting of sodium carboxymethylcellulose, sodium alginate, and xanthan gum, and a moisturizing agent, and has a viscosity of 10,000 to 50,000 mPa·s at 25°C, as a composition that quickly penetrates moisture into dry matter in the oral cavity, making it easier to clean, and increasing the retention of the composition in the oral cavity.

[0005] Patent Document 2 describes a composition containing cysteine ​​protease and at least one thickening polysaccharide selected from the group consisting of xanthan gum, guar gum, hyaluronic acid, and hydroxyethyl cellulose as a tongue coating remover that can remove firmly adhered tongue coating while minimizing the burden on the subject.

[0006] Patent Document 3 describes a dry mouth phlegm softener that contains a lubricant (maltitol) as the main ingredient, viscosity imparting agents (hydroxyethyl cellulose, tamarind gum) and a foaming agent (dipotassium glycyrrhizinate), and is composed of 50% or more purified water, as a composition that can soften dry phlegm adhering to the oral mucosa in a short period of time and easily remove the dry phlegm without damaging the oral mucosa.

[0007] Patent Document 4 describes an oral composition containing 0.01 to 20% by mass of glyceryl glucoside, which is a composition that quickly supplies moisture to the dry oral cavity, thereby relieving dryness in the oral cavity, and quickly penetrates moisture into dried and stuck phlegm and dirt in the oral cavity, making it easier to clean.

[0008] Pectin jelly is described in Patent Documents 5 to 7. These patent documents relate to jelly drinks or jelly foods for people with dysphagia. In recent years, the number of people with dysphagia has rapidly increased with the aging population, and aspiration has become a social problem. Aspiration occurs when water or food is not properly guided into the esophagus and ends up in the lungs. This aspiration triggers a severe cough reflex, preventing oral intake, leading to malnutrition and life-threatening complications. Hydration is particularly important for the elderly to prevent dehydration. However, water is most susceptible to aspiration due to its rapid passage through the pharynx during swallowing. Therefore, in recent years, jelly drinks for hydration have been developed to slow the passage of water through the pharynx during swallowing and reduce aspiration risk. However, conventionally sold jelly drinks (jelly made from carrageenan or agar) have suffered from syneresis (a phenomenon in which water separates from the jelly itself in the product container). While this syneresis has been welcomed because it enhances palatability by imparting a fruity flavor, it has been disliked by patients with swallowing disorders due to the increased risk of aspiration. Against this background, Patent Documents 5 to 7 relate to "jelly foods that do not syneresis for a long period of time," "jelly drinks that do not lead to aspiration," and "hydration jelly drinks for people with difficulty chewing and swallowing, characterized by the absence of syneresis," all of which are intended to safely hydrate people with dysphagia. The "filter paper method" shown as a test method in these patent documents is also intended to demonstrate the absence of syneresis that leads to aspiration, and there is no mention or suggestion whatsoever of the permeability of moisture to the target of application by the oral dry matter remover of the present invention. Patent Documents 5 to 7 are completely different in target population and purpose from the oral dry matter remover of the present invention. [Prior art documents] [Patent documents]

[0009] [Patent Document 1] Japanese Patent Application Laid-Open No. 2010-138080 [Patent Document 2] Japanese Patent Application Laid-Open No. 2016-204330 [Patent Document 3] Japanese Patent Application Laid-Open No. 2010-285374 [Patent Document 4] Japanese Patent Application Laid-Open No. 2012-153619 [Patent Document 5] Patent No. 6453547 [Patent Document 6] Patent No. 6546788 [Patent Document 7] Japanese Patent Publication No. 2020-62060 Summary of the Invention [Problem to be solved by the invention]

[0010] An object of the present invention is to provide a method for appropriately evaluating the water permeability of an oral dry matter remover, and further to provide an oral dry matter remover having extensibility, adhesiveness and water permeability. [Means for solving the problem]

[0011] To solve the above-mentioned problems, the inventors first investigated a method for accurately evaluating the moisture permeability of an oral dry matter remover into a target object. Patent Document 1 describes a conventional evaluation method, known as the "Moisture Donation Measurement Experimental Method," which evaluates the moisture permeability of a remover into filter paper simulating dry matter in the mouth. A metal plate (22 mm diameter, 1.5 mm thick) with a 5 mm diameter hole was placed in the center of an ADAVATEC 5B (110 mm diameter). 25 μl of sample was placed in the hole and allowed to stand at room temperature for 10 minutes. The diameter of the discolored area due to water absorption by the filter paper was measured. The configuration is shown in Figure 1 (left). However, the inventors recognized two problems with this method. One is the influence of gravity on the direction of permeation. Dry oral exfoliated epithelial membranes often form on the upper palate, and when applying a product to dry oral exfoliated epithelial membranes formed on the upper palate, it is necessary to be able to measure the force of permeation against gravity. The second problem is the issue of gaps. If the viscosity of the applied composition is low, it will be pushed by gravity into the gaps and then penetrate into the filter paper. Therefore, the inventors have independently devised the "top-up filter paper method." The configuration of this method is shown in Figure 1 (right).

[0012] Furthermore, to facilitate swallowing for those with dysphagia, it is important that the jelly does not adhere to the oral cavity or throat. Therefore, the smoothness of the jelly is important. Patent Documents 5 to 7 describe that pectin jelly has a slight degree of water release that does not lead to aspiration, moistening the surface of the jelly, allowing it to pass through the pharynx without adhering to the oral cavity or throat. Conversely, for the subjects of the present invention, "smoothness" is a negative characteristic that reduces adhesion to dry matter in the oral cavity. After further research, the inventors discovered that an oral dry matter remover consisting of a jelly-like composition containing pectin with a specified DE value has suitable spreadability and adhesiveness, and can penetrate moisture into the target more quickly and sustainably than oral moisturizers using conventional thickeners, thereby completing the present invention.

[0013] That is, the present invention is as follows. 1. A method for evaluating the water permeability of oral dry matter removers using the diameter of the water permeation circle measured by the following filter paper method: Top-up filter paper method; A container with a water-impermeable bottom and cylindrical portion is filled with the sample without leaving any gaps, and water-permeable paper is placed on top of it so that it is in contact with the sample. After a specified time has passed, the longest and shortest diameters of the area where water has penetrated into the paper (water penetration circle) are measured, and the average value is taken as the diameter of the water penetration circle. 2. An oral dry matter remover comprising a jelly-like composition containing pectin, divalent metal ions, and water, The DE value of pectin is 20 to 50. An oral dry matter remover having a water penetration circle diameter of 28 mm or more after 3 minutes, 32 mm or more after 10 minutes, and / or 36 mm or more after 30 minutes, as measured by the top filter paper method described in the preceding paragraph 1, satisfying at least the following conditions: Top-up filter paper method; The sample is tightly packed into an acrylic cylinder with an inner diameter of 23 mm, an outer diameter of 25 mm, and a height of 15 mm, the bottom of which is covered with paraffin film, and a cellulose filter paper (quantitative filter paper No. 5B (diameter 90 mm), manufactured by Advantec) is placed on top. The container is then left to stand in an incubator at 25°C. After a predetermined time (3 minutes, 10 minutes, 30 minutes) has elapsed, the longest and shortest diameters of the area where water has penetrated the filter paper (water penetration circle) are measured, and the average value is taken as the diameter of the water penetration circle. 3. The hardness of the jelly composition measured in accordance with the standards for foods for people with dysphagia (filling height: 15 mm, measurement temperature: 25°C) is 1640 to 7479 N / m 2 3. The oral dry matter remover according to the preceding item 2, 4. The oral dry matter remover according to the preceding item 2 or 3, wherein the pectin content of the jelly composition is 0.5 to 3.0% by weight. 5. The divalent metal ion is calcium ion, 5. The oral dry matter remover according to any one of items 2 to 4 above, wherein the calcium ion content of the jelly composition is 0.05 to 1.5% by weight in terms of calcium lactate. 6.DE value is 30-45, The hardness of the jelly composition measured in accordance with the standards for food approval for people with dysphagia (filling height 15 mm, measurement temperature 25°C) is 2000 to 6158 N / m 2 6. The oral dry matter remover according to any one of items 2 to 5 above, wherein 7.DE value is 39-45, 7. The oral dry matter remover according to any one of the preceding items 2 to 6, wherein the diameter of the water penetration circle after 3 minutes, after 10 minutes, and after 30 minutes, measured by the top filter paper method described in the preceding item 1, is 30 to 78 mm, 40 to 80 mm, and 46 to 80 mm. 8. The DE value is 30-34. the divalent metal ion is a calcium ion, 7. The oral dry matter remover according to any one of items 2 to 6 above, wherein the calcium ion content of the jelly composition is 0.2 to 0.4% by weight in terms of calcium lactate. 9. The oral dry matter remover according to any one of the preceding items 2 to 5, wherein the pectin is at least one selected from the group consisting of citrus fruit-derived pectin having a DE value of 33 to 50, apple-derived pectin having a DE value of 23 to 34, and combinations thereof. 10. The oral dry matter remover according to any one of the preceding items 2 to 9, which is applied to oral dry matter, oral mucosa and / or tooth surfaces. 11. An oral dry matter remover described in any one of the preceding paragraphs 2 to 10, wherein the jelly composition further contains at least one selected from the group consisting of pH adjusters, dispersants, fragrances, taste-imparting agents, colorants, and functional ingredients. 12. The oral dry matter remover according to any one of the preceding items 2 to 11, wherein the jelly composition is substantially free of any thickener other than pectin. 13. An oral dry matter remover described in the preceding paragraph 12, in which the thickener other than pectin is selected from the group consisting of gums, alginic acid and its salts, vegetable proteins, synthetic polymers, cellulose derivatives and their salts, soybean polysaccharides, carrageenan, fucoidan, casein, gelatin, and glucomannan. [Effects of the Invention]

[0014] According to the present invention, it is possible to provide a method for evaluating the permeability of water in an oral dry matter remover in a direction against gravity, and to provide an oral dry matter remover that has suitable extensibility and adhesiveness and is capable of allowing the water in the oral dry matter remover to permeate into an application target quickly and continuously. [Brief explanation of the drawings]

[0015] [Figure 1] A conceptual diagram of a method for correctly evaluating the permeability of moisture in an oral dry matter remover to an application target. The left diagram shows the configuration of the moisture supply measurement experiment. The right diagram shows the top filter paper method of the present invention. [Figure 2] Schematic diagram showing the relationship between DE value and calcium lactate concentration in jelly formation. [Figure 3] Schematic diagram of the evaluation method for sensory evaluation of extensibility and adhesiveness. [Figure 4]Results of evaluation of moisture permeability of commercially available oral moisturizers using the top-up filter paper method (Reference Example 1) [Figure 5] Results of evaluation of water permeability of thickener aqueous solution using the top filter paper method (Reference Example 2) [Figure 6] Relationship between water permeability, adhesion, and hardness of jelly-like composition (Test Example 3) DETAILED DESCRIPTION OF THE INVENTION

[0016] The present invention will be described in detail below.

[0017] The present invention encompasses a method for evaluating the water permeability of an oral dry matter remover using as an index the diameter of the water permeation circle measured by the following top filter paper method: Top-up filter paper method; A container with a water-impermeable bottom and cylindrical portion is filled with the sample without leaving any gaps, and water-permeable paper is placed on top of it so that it is in contact with the sample. After a specified time has passed, the longest and shortest diameters of the area where water has penetrated into the paper (water penetration circle) are measured, and the average value is taken as the diameter of the water penetration circle.

[0018] The material of the container having a water-impermeable bottom and cylindrical portion in the present invention is not particularly limited as long as it is impermeable (permeates through) water, and may be, for example, acrylic, paraffin, etc. The water-permeable paper in the present invention is not particularly limited as long as it is permeable to water, but filter paper is preferred, and cellulose filter paper is more preferred. In the present invention, the water permeability of a container having a water-impermeable bottom and cylindrical portion can be evaluated by placing the top (open end) of the container vertically upward and placing water-permeable paper on the top in contact with the sample. A preferred example of the top-up filter paper method is the top-up filter paper method under the following conditions. Top-up filter paper method; The sample is tightly packed into an acrylic cylinder with an inner diameter of 23 mm, an outer diameter of 25 mm, and a height of 15 mm, the bottom of which is covered with paraffin film, and a cellulose filter paper (quantitative filter paper No. 5B (diameter 90 mm), manufactured by Advantec) is placed on top. The container is then left to stand in an incubator at 25°C. After a predetermined time (3 minutes, 10 minutes, 30 minutes) has elapsed, the longest and shortest diameters of the area where water has penetrated the filter paper (water penetration circle) are measured, and the average value is taken as the diameter of the water penetration circle.

[0019] The dry mouth remover of the present invention comprises a jelly-like composition containing pectin having a predetermined DE value, divalent metal ions, and water.

[0020] Pectin has a structure consisting of long chains of galacturonic acid and methyl-esterified galacturonic acid. The degree of esterification of galacturonic acid in a pectin molecule (the proportion of methyl-esterified galacturonic acid) is called the DE value. Pectin with a DE value of 50 or higher is called high methoxyl (HM) pectin, while pectin with a DE value of less than 50 is called low methoxyl (LM) pectin. Two types of pectin gels are known: gels made from HM pectin and gels made from LM pectin. Gels are formed when the galacturonic acid in pectin is cross-linked by divalent metal ions such as calcium ions. Therefore, the DE value and divalent metal ion concentration are factors that significantly affect the physical properties of pectin gels.

[0021] Figure 2 shows a conceptual diagram of the region where jelly is formed. In the study for this patent, the physical properties were compared under the conditions of the gelling region for each DE value. Furthermore, depending on the fruit from which pectin is derived, the physical properties of the gel may differ even at the same DE value. Generally, pectin derived from citrus fruits such as lime and lemon forms a firm gel, while pectin derived from apple forms a soft gel.

[0022] The DE value of the pectin used in the present invention may be 20 to 50, and may be, for example, 20 to 45, 23 to 45, 30 to 45, 39 to 45, or 30 to 34. The pectin used in the present invention may be either citrus fruit-derived or apple-derived, and two or more types of pectin may be used in combination. The DE value of the citrus fruit-derived pectin used in the present invention is preferably 27 to 50, from the viewpoint of having both excellent water permeability and extensibility. From the viewpoint of having particularly excellent water permeability and extensibility, a DE value of 33 to 50 is more preferable, and a DE value of 33 to 45 is even more preferable. The DE value of the apple-derived pectin used in the present invention is preferably 23 to 34, from the viewpoint of having particularly excellent water permeability and extensibility. The pectin used in the present invention may be at least one selected from the group consisting of citrus fruit-derived pectins having a DE value of 33 to 50, apple-derived pectins having a DE value of 23 to 34, and combinations thereof.

[0023] The content of pectin in the jelly composition of the present invention is not particularly limited as long as it does not impair the effects of the present invention, and may be, for example, 0.1 to 0.8 wt%, 0.5 to 2.0 wt%, 1.3 to 5.0 wt%, 0.6 to 3.0 wt%, 0.7 to 3.0 wt%, 0.8 to 3.0 wt%, 0.9 to 3.0 wt%, 1.0 to 3.0 wt%, 1.1 to 3.0 wt%, 1.2 to 3.0 wt%, 1.3 to 3.0 wt%, 1.4 to 3.0 wt%, 1.5 to 3.0 wt%, 1.6 to 3.0 wt%, 1.7 to 3.0 wt%, 1.8 to 3.0 wt%, 1.9 ...9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, 1.9 to 3.0 wt%, From the viewpoint of adhesion and penetration, the pectin content is preferably 0.1 to 5.0% by weight, more preferably 0.2 to 4.0% by weight, more preferably 0.3 to 3.0% by weight, more preferably 0.4 to 3.0% by weight, more preferably 0.5 to 3.0% by weight, more preferably 0.6 to 2.5% by weight, more preferably 0.7 to 2.0% by weight, and more preferably 0.8 to 1.8% by weight. When two or more types of pectin are used in combination, the pectin content refers to the total amount.

[0024] The divalent metal ion in the present invention is not particularly limited, but examples thereof include calcium ions and magnesium ions, with calcium ions being preferred. The divalent metal ion can be incorporated, for example, by blending a divalent metal salt. The divalent metal salt is not particularly limited as long as it is food hygienically or pharmacologically acceptable, but examples thereof include calcium salts and magnesium salts, with calcium salts being preferred. Examples of calcium salts include calcium lactate, calcium chloride, calcium citrate, calcium gluconate, calcium carbonate, calcium acetate, calcium oxide, calcium sulfate, and the like, with calcium lactate being preferred. When the jelly composition of the present invention contains calcium ions, the content is not particularly limited as long as it does not impair the effects of the present invention, but is preferably 0.05 to 1.5 wt. % (free calcium ion concentration 65 to 1950 ppm) in terms of calcium lactate weight, more preferably 0.1 to 1.5 wt. %, more preferably 0.1 to 1.0 wt. %, more preferably 0.1 to 0.9 wt. %, more preferably 0.1 to 0.8 wt. %, more preferably 0.1 to 0.7 wt. %, more preferably 0.1 to 0.6 wt. %, more preferably 0.1 to 0.5 wt. %, and more preferably 0.1 to 0.4 wt. When the DE value of the pectin in the jelly composition of the present invention is 30 to 34, the calcium ion content in terms of calcium lactate weight is preferably 0.2 to 0.4 wt. %, more preferably 0.2 to 0.3 wt. %. When the jelly composition of the present invention contains divalent metal ions other than calcium ions, the content of the divalent metal ions may be such that the concentration of free divalent metal ions is equivalent to the concentration of free calcium ions when the jelly composition of the present invention contains calcium ions in terms of the weight of calcium lactate. When two or more types of divalent metal ions are used in combination, the content of divalent metal ions refers to the total amount. In the present invention, the "jelly composition" is not particularly limited as long as it contains pectin, divalent metal ions, and water, but is preferably a gel-state composition.

[0025] The hardness of the jelly composition of the present invention, measured in accordance with the standards for approval of foods for people with dysphagia (however, the filling height is 15 mm and the measurement temperature is 25°C), is 1640 to 7479 N / m from the viewpoint of having both excellent water permeability and appropriate extensibility and adhesiveness. 2 is preferable, and the hardness is 1700 to 7400 N / m 2 More preferably, 1700 to 7300 N / m 2 More preferably, 2000 to 6158 N / m 2 More preferably, 2000 to 4000 N / m 2 The hardness of the jelly composition of the present invention is, for example, 2000 to 6900 N / m 2 , 2000~6700N / m 2 , 2300~6500N / m 2 , 2500~6400N / m 2 , 2500~6200N / m 2 , 2611~6158N / m 2 , 2700~6100N / m 2 , 2800~6000N / m 2 , 2900~6000N / m 2 , 3000~6000N / m 2 , 3100~6000N / m 2 , 3200~6000N / m 2 , 3300~6000N / m 2 , 3400~6000N / m 2 , 3500~6000N / m 2 , 3600~6000N / m 2 , 3700~6000N / m 2 , 1900~7000N / m 2 , 2000~7200N / m 2 , 2300~7200N / m 2 , 2500~7100N / m 2 , 2611~7018N / m 2 , 2700~6400N / m 2 , 2800~6400N / m 2 , 3000~6400N / m 2 , 3200~6400N / m 2 , 3263~6400N / m 2 , 3400~6400N / m2 , 3600~6400N / m 2 , 3800~6400N / m 2 , 4000~6400N / m 2 , 4100~6400N / m 2 In this specification, the "hardness of a jelly-like composition measured by a method conforming to the approval standards for foods for people with dysphagia" refers to the hardness (N / m) measured in accordance with the "Testing methods for foods for people with dysphagia" (filling height 15 mm, measurement temperature 25°C) set forth in Appendix 2 of the "Complete revision of the 'Approval for Labeling Foods for Special Dietary Uses' (Dietary Table No. 296, Notice from the Deputy Director-General of the Consumer Affairs Agency, September 9, 2019)." 2 ) means

[0026] The jelly composition of the present invention is substantially free of thickeners other than pectin. In this specification, "substantially free of thickeners other than pectin" means that the composition does not contain any thickeners other than pectin, or that the composition may contain thickeners other than pectin in an amount that does not exert its effects or cause side effects, or that the composition may contain thickeners other than pectin as impurities unavoidably mixed in during production. For example, the content of thickeners other than pectin in the jelly composition may be 0.1% by weight or less, preferably 0.05% by weight or less, and more preferably 0.01% by weight or less.

[0027] Examples of thickeners other than pectin include gums (xanthan gum, guar gum, tamarind gum, locust bean gum, tamarind seed gum, Caesalpinia spinosa gum, tara gum, gellan gum, gum arabic, etc.), alginic acid and its salts (sodium alginate, potassium alginate, calcium alginate, etc.), vegetable proteins (wheat protein, rice protein, soy protein, etc.), synthetic polymers (polyacrylic acid, polymethacrylic acid, acrylic acid-alkyl methacrylate copolymer, polyethylene glycol, polyvinylpyrrolidone, etc.), cellulose derivatives (carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, etc.) and their salts, soy polysaccharides, carrageenan, fucoidan, casein, gelatin, glucomannan, etc.

[0028] The oral dry matter remover of the present invention has water permeability, which refers to the ability of the oral dry matter remover to release water and penetrate the target against gravity, and can be evaluated by the amount of water released against gravity from the oral dry matter remover, specifically, by the diameter of the water penetration circle of the jelly composition measured by the above-mentioned filter paper method.

[0029] The oral dry matter remover of the present invention has extensibility. The extensibility can be evaluated by the evaluation method and evaluation criteria described in the Examples below. Extensibility can be rephrased as ease of application, and the higher the extensibility, the easier it is to apply uniformly, while the lower the extensibility, the more likely it is that application will be uneven, and the more likely it is that applied areas and unapplied areas will occur.

[0030] The oral dry matter remover of the present invention has adhesive properties. Adhesion can be evaluated by the evaluation method and evaluation criteria described in the Examples below. The higher the adhesiveness, the longer the oral dry matter remover will adhere to the target, such as oral dry matter, oral mucosa, or tooth surface, without peeling off. The oral dry matter remover of the present invention has both extensibility and adhesive properties, making it easy to apply to dry matter formed in the oral cavity or dry oral mucosa with a finger or an oral sponge brush, and is less likely to drip when applied to the upper palate, tooth surface, etc.

[0031] The target of the oral dry matter remover of the present invention is people who have oral dry matter or people suspected of having oral dry matter, preferably people who have oral dry matter and are unable to take oral intake.

[0032] In the present invention, "dry oral matter" refers to dry matter present in the oral cavity, such as exfoliated epithelial membrane, tongue coating, dry sputum, and crusts. Exfoliated epithelial membrane is caused by dry mouth and is mainly dried waste, saliva, and / or food debris in the oral cavity. Dry oral matter is mainly removed by scrubbing with oral hygiene tools such as toothbrushes and oral sponge brushes, and can be softened and made easier to remove by allowing moisture to penetrate the dry oral matter. The oral dry matter remover of the present invention can soften and remove the dry oral matter by allowing moisture to penetrate the dry oral matter, and / or can make it easier to remove (assist removal).

[0033] When removing dry oral matter using the oral dry matter remover of the present invention, the time required for moisture penetration (softening) varies depending on the size and dryness of the dry oral matter, such as oral exfoliated epithelial membrane, and its location in the oral cavity. Furthermore, moisture must penetrate against gravity to penetrate into dry oral matter that has formed in the maxilla of the oral cavity. Therefore, in the present invention, the performance of the oral dry matter remover in facilitating the removal of dry oral matter, specifically, the moisture penetration (softening) effect against gravity for each required time, was evaluated by measuring the diameter of the moisture penetration circle after 3 minutes, 10 minutes, and / or 30 minutes using the overlay filter paper method.

[0034] In a series of procedures in professional oral care, it is desirable that the penetration of moisture into dry substances in the oral cavity (soaking) and the removal of dry substances in the oral cavity can be completed in a short time. From the viewpoint of moisture penetration in a short time, the diameter of the moisture penetration circle after 3 minutes, measured by the above-mentioned filter paper method, is 28 mm or more, preferably 28 to 78 mm, more preferably 29 to 78 mm, more preferably 30 to 78 mm, more preferably 30 to 70 mm, more preferably 30 to 60 mm, more preferably 30 to 55 mm, and more preferably 30 to 50 mm. If the diameter of the penetration circle after 3 minutes is less than 28 mm, the effect of removing exfoliated epithelial membranes and the like in a short time tends to be insufficient.

[0035] Depending on the size, location, dryness, etc. of the dried matter in the oral cavity, it may take time for moisture to penetrate (soak) and be removed. From the viewpoint of moisture penetration over a relatively long period of time, the diameter of the moisture penetration circle after 10 minutes, measured by the above-mentioned filter paper method, is 32 mm or more, preferably 32 to 90 mm, more preferably 35 to 85 mm, more preferably 36 to 85 mm, more preferably 38 to 85 mm, more preferably 39 to 85 mm, more preferably 40 to 80 mm, more preferably 40 to 70 mm, and more preferably 40 to 65 mm. If the average diameter of the penetration circle after 10 minutes is less than 32 mm, the effect of removing exfoliated epithelial membranes, etc., tends to be insufficient over a relatively long period of time.

[0036] Furthermore, from the viewpoint of long-term moisture permeability, the diameter of the moisture permeation circle after 30 minutes measured by the above-mentioned filter paper method is 36 mm or more, preferably 36 to 90 mm, more preferably 38 to 90 mm, more preferably 39 to 90 mm, more preferably 40 to 90 mm, more preferably 41 to 90 mm, more preferably 43 to 90 mm, more preferably 45 to 90 mm, more preferably 46 to 90 mm, more preferably 46 to 85 mm, more preferably 46 to 80 mm, more preferably 47 to 80 mm, more preferably 48 to 80 mm, more preferably 49 to 80 mm, and more preferably 50 to 75 mm. If the average diameter of the permeation circle after 30 minutes is less than 36 mm, the effect of removing exfoliated epithelial membranes and the like over a long period of time tends to be insufficient. If the diameter of the water penetration circle after 3 minutes is 28 mm or more, the diameter of the water penetration circle after 10 minutes is 32 mm or more, and the diameter of the water penetration circle after 30 minutes is 36 mm or more, then not only is the product excellent in rapid water penetration in a short period of time, but the excellent water penetration is maintained for at least 30 minutes, so the product also has excellent sustained water penetration.

[0037] The present invention encompasses a method for removing dry oral matter, comprising the step of applying the oral dry matter remover of the present invention to the oral cavity of a subject. The step of applying to the oral cavity of the subject preferably comprises a step of coating the oral cavity of the subject. The method preferably further comprises a step of allowing a certain period of time (e.g., 30 seconds to 2 hours, 1 minute to 2 hours, 1 minute to 1 hour, 1 minute to 40 minutes, 1 minute to 30 minutes, 3 minutes to 30 minutes, 5 minutes to 30 minutes, 3 minutes to 5 minutes, etc.) to pass after the step of applying to the oral cavity of the subject, and / or a step of removing the dry oral matter. The step of applying to the oral cavity of the subject, the step of allowing the certain period of time to pass, and the step of removing the dry oral matter may be repeated in any order depending on the size, location, dryness, etc. of the dry oral matter. For example, a series of steps may be repeated 2 to 5 times, including the step of applying the composition to the oral cavity of the subject, the step of allowing the composition to stand for a certain period of time, and then the step of removing the dried oral matter, or the step of applying the composition to the oral cavity of the subject, the step of allowing the composition to stand for a certain period of time, and then the step of removing the dried oral matter. The method for removing the dried oral matter in the step of removing the dried oral matter is not particularly limited, but is preferably performed using an oral hygiene tool such as an oral sponge brush or a medical material such as gauze.

[0038] The method for applying the oral dry substance remover of the present invention to the oral cavity of a subject is not particularly limited as long as it allows the moisture in the oral dry substance remover of the present invention to penetrate into the oral dry substances of the subject, facilitating their removal, but the oral dry substance remover of the present invention is preferably brought into contact with the oral cavity of the subject, more preferably applied to the oral cavity of the subject, and more preferably applied to the oral dry substances, oral mucosa, and / or teeth of the subject. The amount of the oral dry substance remover of the present invention to be applied can be adjusted appropriately depending on the size, location, dryness, etc. of the oral dry substances, and is not particularly limited, and may be, for example, 0.5 to 10 g per application.

[0039] The jelly composition of the present invention may contain other ingredients in addition to the above-mentioned components. Examples of other ingredients include pH adjusters, dispersants, surfactants, flavorings, sweeteners, colorants, preservatives, antibacterial agents, antifoaming agents, and functional ingredients. These ingredients are not particularly limited as long as they are suitable for use in pharmaceuticals, foods, or cosmetics. Examples of pH adjusters include inorganic acids such as phosphoric acid, inorganic acid salts such as sodium monohydrogen phosphate, sodium dihydrogen phosphate, potassium monohydrogen phosphate, and potassium dihydrogen phosphate, organic acids such as citric acid, malic acid, pyrophosphoric acid, tartaric acid, succinic acid, fumaric acid, gluconic acid, lactic acid, and acetic acid, or their organic acid salts (e.g., trisodium citrate), and bases such as sodium hydroxide and sodium bicarbonate. These may be used alone or in combination of two or more. The content of the pH adjuster in the jelly composition of the present invention is not particularly limited, but may be 0.01 to 5 wt %, preferably 0.1 to 2 wt %, and more preferably 0.2 to 1.6 wt %. When two or more pH adjusters are used, the total amount refers to the total amount. Examples of dispersants include sugar alcohols such as dextrin, maltitol, sorbitol, lactitol, and xylitol, and these can be used alone or in combination of two or more. The content of the dispersant in the jelly-like composition of the present invention is not particularly limited, but may be 0.01 to 15% by weight, preferably 0.5 to 10% by weight, and more preferably 3 to 10% by weight. When two or more dispersants are used, the total amount refers to the total amount. Examples of surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants. Examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, N-acyl sarcosinates such as sodium N-lauroyl sarcosinate, and N-acyl glutamates.Examples of nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters and maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene higher alcohol ethers, fatty acid alkanolamides, polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. Examples of amphoteric surfactants include betaine surfactants and imidazoline surfactants. These surfactants can be used alone or in combination of two or more. By incorporating a surfactant into the oral dry matter remover of the present invention, the penetration of water into the oral dry matter can be further promoted. Examples of flavorings include menthol, peppermint oil, spearmint oil, fruit-derived essential oils, and various masking flavors, which can be used alone or in combination of two or more. Examples of sweeteners include saccharin, saccharin sodium, sodium glycyrrhizinate, aspartame, stevia, sucralose, erythritol, acesulfame K, etc., which can be used alone or in combination of two or more. Coloring agents include natural or synthetic pigments, which can be used alone or in combination of two or more. Examples of preservatives include parabens (parahydroxybenzoic acid esters) such as methylparaben, ethylparaben, isopropylparaben, propylparaben, butylparaben, isobutylparaben, and benzylparaben, as well as sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, or salts thereof (e.g., sodium benzoate), which can be used alone or in combination of two or more. Examples of antibacterial agents include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, dequalinium chloride, chlorhexidine salts, triclosan, isopropylmethylphenol, bisabolol chlorhexidine, hinokitiol, peptides, catechins, lactoferrin, etc., and these can be used alone or in combination of two or more.Examples of the defoaming agent include silicone-based defoaming agents, oil-based defoaming agents, fatty acid ester-based defoaming agents, alcohol-based defoaming agents, and sulfate ester-based defoaming agents, and these can be used alone or in combination of two or more.

[0040] The method for producing the dry oral matter remover of the present invention is not particularly limited, and may include, for example, the steps of heating a mixture of pectin, water, and other ingredients to 80 to 100°C, adding a mixture of a divalent metal salt and water heated to approximately the same temperature as the mixture, heating, and cooling to prepare a jelly-like composition. The method for producing the dry oral matter remover of the present invention may further include the step of filling the jelly-like composition into a stick package or a tube container. The volume filled into the stick package is not particularly limited, and may be, for example, 3 g to 20 g or 3 to 15 g. The volume filled into the tube container is not particularly limited, and may be, for example, 20 g to 150 g or 50 g to 150 g.

[0041] The jelly composition of the present invention can also be used as an oral mucosa moistening agent comprising the jelly composition. The oral mucosa moistening agent of the present invention can penetrate moisture into the oral mucosa of the target oral mucosa to moisten the oral mucosa. [Example]

[0042] EXAMPLES The present invention will be specifically explained below by showing examples and comparative examples in order to deepen understanding of the present invention, but it goes without saying that these do not limit the scope of the present invention.

[0043] The moisture permeability of each sample was measured using the following filter paper topping method, and the moisture permeability (the ability to release moisture and allow moisture to permeate into an object) was evaluated based on the diameter of the moisture permeation circle. [Additional filter paper method] A sample stored at 25°C was tightly packed into an open-top container made of an acrylic cylinder with an inner diameter of 23 mm, an outer diameter of 25 mm, and a height of 15 mm, the bottom of which was covered with paraffin film, using a 50 ml Terumo syringe (outlet inner diameter: 4 mm). A cellulose filter paper (quantitative filter paper No. 5B (diameter 90 mm), manufactured by Advantec) was placed on top and the container was left to stand in an incubator at 25°C. After a predetermined time (3 minutes, 10 minutes, 30 minutes) had passed, the longest and shortest diameters of the area where water had penetrated the filter paper (water penetration circle) were measured, and the average value was taken as the diameter of the water penetration circle. When the moisture in the composition penetrates against gravity, the diameter of the penetration circle becomes larger than the outer diameter of the container (25 mm). If this diameter increases over time, it indicates that the composition has sustained penetration power.

[0044] [Sensory evaluation] Two expert panelists performed a sensory evaluation of the spreadability during application and adhesion after application. The evaluation method and criteria were as follows:

[0045] <Method for evaluating extensibility> An appropriate amount of the prepared jelly-like composition was filled into a 50 ml Terumo syringe (outlet inner diameter: 4 mm) and extruded into a 25 × 25 mm, 1 mm deep recessed area created on an acrylic plate. A thin acrylic plate was pressed down from above, spreading the jelly over the entire area to create a 25 × 25 mm, 1 mm deep coated area (coated body), which was evaluated according to the following spreadability evaluation criteria. A conceptual diagram of this evaluation method is shown in Figure 3.

[0046] <Evaluation criteria for extensibility> 4: No nodules and extensible. 3: Contains soft nodules but is extensible. 2: Contains hard nodules but is extensible. 1: Breaks into hard small pieces and has no extensibility. In this evaluation standard, when a gel was pressed into a 1 mm recessed area with a thin acrylic plate, if the gel spread throughout without cracking, it was evaluated as "extensible," and if the gel did not spread throughout but cracked, it was evaluated as "not extensible." Small pieces refer to jelly chunks with a maximum diameter of approximately 2 mm to 4 mm. Regarding the hardness of the small pieces, if the small pieces could be crushed by pressing with a finger, they were evaluated as "soft," and if they could not be crushed by pressing with a finger, they were evaluated as "hard."

[0047] <Method for evaluating adhesion> The applied body prepared by the spreadability evaluation method was stood upright, and after 1 minute, the changes in the entire applied body and the surface of the applied body were evaluated according to the following criteria for adhesion.

[0048] <Adhesion evaluation criteria> ●: The entire coated body remained in the same position on the acrylic plate without slipping at all, and there was no shifting of the coated body surface at all. ◯: The entire applied body was not slippery, but some slippage occurred on the surface of the applied body. △: The entire applied body slipped, but the slippage was less than 5 mm and stopped immediately. ×: The entire applied body slid for 5 mm or more.

[0049] Reference example 1 The moisture permeability of commercially available oral moisturizers that advertise the removal of oral exfoliated epithelial membranes and tongue coating while also moisturizing was evaluated using the top-up filter paper method. The commercially available oral moisturizers used were "Oral Plus Oral Gel Moisture Keep" (manufactured by Asahi Group Foods Co., Ltd.), "Mouthwash Gel" (manufactured by Nippon Dental Pharmaceuticals Co., Ltd.), "N.act Oral Removal Gel" (manufactured by Earth Chemical Co., Ltd.), "Wet Aid (gel type)" (manufactured by Dent Care Co., Ltd.), "Wet Aid (foam type)" (manufactured by Dent Care Co., Ltd.), and Viva Jel-ette (manufactured by Tokyo Giken Co., Ltd.). "Oral Plus" is an oral moisturizer commercialized based on Patent Document 1. "Wet Aid" is a remover commercialized based on Patent Document 2.

[0050] The results are shown in Table 1 and Figure 4. The dotted line in Figure 4 indicates the 25 mm outer diameter of the acrylic cylinder. For none of the oral moisturizers did the moisture penetration circle continue to grow after 3 minutes, 10 minutes, or 30 minutes, and did not extend significantly beyond the outer diameter of the acrylic cylinder. Therefore, it was confirmed that conventional oral moisturizers do not provide sufficient sustained moisture release and are unable to adequately moisturize dry matter in the mouth or the oral mucosa.

[0051] [Table 1]

[0052] Reference example 2 In Reference Example 1, the reason why the moisture penetration circle did not increase sustainably using the top-up filter paper method with commercially available oral moisturizers was thought to be due to the thickeners that are added to the oral moisturizers to give them shape retention (maintaining their shape as a drug) and adhesiveness.The moisture penetration was also evaluated using the top-up filter paper method for aqueous solutions of thickeners that are widely used in the above-mentioned prior art literature and oral moisturizers.

[0053] [Preparation of Comparative Example 1] 2 g of carboxymethyl cellulose (CMC Daicel 1390, manufactured by Daicel Miraize Co., Ltd.) was mixed in advance with 4 g of dextrin (Oil Q No. 50, manufactured by Nippon Starch Chemical Co., Ltd.), and the mixture was added to 194 g of purified water (adjusted to a total of 200 g) with stirring to dissolve and disperse the mixture. The mixture was left to stand overnight at 25°C (Comparative Example 1), and its water permeability was evaluated using the filter paper topping method. The evaluation results are shown in Table 2.

[0054] [Preparation of Comparative Examples 2 to 8] Comparative Examples 2 to 8 were prepared using the same procedures as in Comparative Example 1 according to the compositions listed in Table 2, and their water permeability was evaluated using the filter paper topping method. The evaluation results are shown in Table 2. The thickeners used were carboxymethylcellulose (CMC Daicel 1390, Daicel Miraize Co., Ltd.), hydroxyethylcellulose (SE900, Daicel Miraize Co., Ltd.), hydroxypropylmethylcellulose (NE-4000, Shin-Etsu Chemical Co., Ltd.), xanthan gum (SAN-ACE NXG-S, San-Ei Gen F.F.I.), guar gum (purified guar gum PF-20, DSP Gokyo Food & Chemical Co., Ltd.), tamarind gum (Glyloid 6C, DSP Gokyo Food & Chemical Co., Ltd.), sodium alginate (Chimica Algin I-3, Chimica Co., Ltd.), and sodium hyaluronate (Nippon Shinyaku Co., Ltd.), and the dispersant used was dextrin (Nippon Starch Chemical Co., Ltd.).

[0055] [Table 2]

[0056] The results are shown in Table 2 and Figure 5. The dotted line in Figure 5 indicates the 25 mm outer diameter of the acrylic cylinder. For all of the thickener solutions, the water penetration circle did not continue to grow after 3, 10, or 30 minutes, and did not significantly extend beyond the outer diameter of the acrylic cylinder. These results suggest that the thickener's water retention ability inhibits water penetration into the coated object, and that it is better not to add a thickener to ensure sufficient water penetration.

[0057] Test Example 1 Considering that the DE value has a significant effect on the physical properties of jelly, we prepared jelly compositions using pectins derived from citrus fruits with various DE values ​​and evaluated their water permeability and extensibility.

[0058] [Preparation of Preparation Example 1-1] (1) 2.4 g of pectin (LM-104AS-J, manufactured by Sansho Co., Ltd.), 8 g of dextrin (Oil Q No. 50, manufactured by Nippon Starch Chemical Co., Ltd.), 0.8 g of citric acid crystal N1560 (manufactured by Maruzen Pharmaceutical Co., Ltd.), 0.38 g of trisodium citrate crystal S (manufactured by Showa Kako Co., Ltd.), and 168.12 g of purified water (adjusted so that the total weight of solutions A and B was 200 g) were mixed and stirred at room temperature to prepare solution A. (2) 0.3 g of calcium lactate (pentahydrate) (manufactured by Fuso Chemical Co., Ltd.) and 20 g of purified water were mixed and stirred at room temperature to prepare liquid B. (3) Solution A was covered with Saran Wrap and heated in a microwave (600W, 1 minute 40 seconds), the Saran Wrap was removed, the mixture was stirred well, and the solution was covered with Saran Wrap again and heated in a microwave (600W, 20 seconds). (4) The Saran Wrap was removed, and Solution B was added dropwise to Solution A while stirring, and they were mixed well. (5) Cover with Saran wrap and heat again in the microwave (600W, 20 seconds). Remove any bubbles on the surface and then cool in a water bath (tap water). (6) The sample was stored in a 25°C thermostatic chamber (product name Cool Incubator CN-25B, manufactured by Mitsubishi Electric Engineering Co., Ltd.) for one day and designated as Preparation Example 1-1. The moisture permeability and extensibility were evaluated using the filter paper topping method. The evaluation results are shown in Table 3.

[0059] [Preparation of Preparation Examples 1-2 to 1-5] Preparation Examples 1-2 to 1-5 were prepared in the same manner as Preparation Example 1-1 according to the compositions shown in Table 3, and the same tests were carried out. The evaluation results are shown in Table 3.

[0060] [Table 3] UNIPECTINE OF645C (manufactured by Unitech Foods), UNIPECTINE OF845C (manufactured by Unitech Foods), LM-105AS-J (manufactured by Sansho Co., Ltd.), UNIPECTINE OF959C SB (manufactured by Unitech Foods).

[0061] As shown in Table 3, for all jelly compositions, the diameter of the water penetration circle after 3 minutes was 28 mm or more, the diameter of the water penetration circle after 10 minutes was 32 mm or more, and the diameter of the water penetration circle after 30 minutes was 36 mm or more. For all jelly compositions, the water penetration circle continuously increased after 3, 10, and 30 minutes. Compared with the conventional oral moisturizers and aqueous thickener solutions shown in Tables 1 and 2, these compositions exhibited very good water penetration, particularly at DE values ​​of 40 or less. Furthermore, differences in water penetration after 3, 10, and 30 minutes were observed among jelly compositions using pectin jellies with different DE values. This indicates that the water penetration of jelly compositions containing citrus fruit-derived pectin is affected by the DE value. Rapid and sustained penetration, with a penetration circle diameter of 28 mm or more after 3 minutes, is preferably achieved with a DE value of 50 or less, more preferably a DE value of 45 or less. Oil Q is a dextrin used to disperse and dissolve the pectin powder in water, but does not affect the properties of the jelly composition. A spreadability rating of 2 or higher allows the jelly composition to be spread while being applied. A spreadability rating of 3 indicates that the composition contains small jelly pieces soft enough to be crushed with a finger, facilitating uniform application. A spreadability rating of 4 indicates that the composition does not contain small pieces, facilitating even more uniform application. The results in Table 3 show that the spreadability rating is 2 or higher at DE values ​​of 27 to 50 and 3 or higher at DE values ​​of 33 to 50. These results demonstrate that oral dry matter removers made of jelly compositions containing citrus fruit-derived pectin possess excellent moisture permeability and spreadability at DE values ​​of 27 to 50, and particularly excellent moisture permeability and spreadability at DE values ​​of 33 to 50.

[0062] Test Example 2 Like the citrus fruit-derived pectin in Test Example 1, jelly compositions were prepared using apple-derived pectin with various DE values, and their water permeability and spreadability were evaluated.

[0063] [Preparation of Preparation Example 2-1] (1) 2.8 g of apple-derived pectin (OF305SB, manufactured by Unitec Foods Co., Ltd.), 8 g of dextrin (Oil Q No. 50, manufactured by Nippon Starch Chemical Co., Ltd.), 0.8 g of citric acid crystals N1560 (manufactured by Maruzen Pharmaceutical Co., Ltd.), 0.38 g of trisodium citrate crystals S (manufactured by Showa Kako Co., Ltd.), and 167.72 g of purified water (adjusted so that the total amount of solutions A and B was 200 g) were mixed and stirred at room temperature to prepare solution A. (2) 0.3 g of calcium lactate (pentahydrate) (manufactured by Fuso Chemical Co., Ltd.) and 20 g of purified water were mixed and stirred at room temperature to prepare liquid B. (3) Solution A was covered with Saran Wrap (registered trademark) and heated in a microwave (600W, 1 minute 40 seconds), the Saran Wrap was removed, the mixture was stirred well, and the solution was covered with Saran Wrap again and heated in a microwave (600W, 20 seconds). (4) The Saran Wrap was removed, and Solution B was added dropwise to Solution A while stirring, and they were mixed well. (5) Cover with Saran wrap and heat again in the microwave (600W, 20 seconds). Remove any bubbles on the surface and then cool in a water bath (tap water). (6) The sample was stored in a 25°C thermostatic chamber (product name Cool Incubator CN-25B, manufactured by Mitsubishi Electric Engineering Co., Ltd.) for one day and designated as Preparation Example 2-1. The moisture permeability and extensibility were evaluated using the filter paper topping method. The evaluation results are shown in Table 4.

[0064] [Preparation of Preparation Examples 2-2 to 2-4] Preparation Examples 2-2 to 2-4 were prepared in the same manner as Preparation Example 2-1 according to the compositions shown in Table 4, and were evaluated in the same manner. The evaluation results are shown in Table 4.

[0065] [Table 4] UNIPECTINE LM-SN-325 (manufactured by Unitech Foods), UNIPECTINE OF805 (manufactured by Unitech Foods), UNIPECTINE OB700SB (manufactured by Unitech Foods).

[0066] As shown in Table 4, for all jelly compositions, the diameter of the water penetration circle after 3 minutes was 28 mm or more, after 10 minutes was 32 mm or more, and after 30 minutes was 36 mm or more. The jelly compositions using apple-derived pectin also showed sustained increases in the water penetration circle after 3, 10, and 30 minutes, demonstrating excellent water penetration compared to the conventional oral moisturizers and aqueous thickener solutions shown in Tables 1 and 2. Furthermore, the water penetration of the apple-derived pectin jelly compositions was 28 mm or more after 3 minutes for all jelly compositions with DE values ​​of 23 to 34, demonstrating rapid and sustained water penetration. Furthermore, the spreadability of all jelly compositions with DE values ​​of 23 to 34 was evaluated as 3 or higher. From the above, it was revealed that oral dry matter removers consisting of a jelly-like composition containing apple-derived pectin have particularly excellent water permeability and extensibility at a DE value of 23 to 34, and that a DE value of 23 to 34 is preferable.

[0067] Test Example 3 Generally, the hardness of a jelly depends on the amount of gelling agent, such as gelatin, carrageenan, or agar, blended. Increasing the amount of gelling agent increases shape retention and adhesiveness, but if it is too high, spreadability is lost. Conversely, if it is too low, the shape retention of the jelly decreases and it will not maintain its adhesiveness when applied. Jelly compositions of various hardnesses were prepared, and the range of hardness of the jelly composition that satisfies the desired water permeability, spreadability, and adhesiveness was investigated.

[0068] [Preparation of Preparation Example 3-1] (1) 1.5 g of pectin (LM-105AS-J, manufactured by Sansho Co., Ltd.), 8 g of dextrin (Oil Q No. 50, manufactured by Nippon Starch Chemical Co., Ltd.), 0.8 g of citric acid crystal N1560 (manufactured by Maruzen Pharmaceutical Co., Ltd.), 0.38 g of trisodium citrate crystal S (manufactured by Showa Kako Co., Ltd.), and purified water adjusted so that the total amount of solutions A and B was 200 g were mixed and stirred at room temperature to prepare solution A. (2) 0.8 g of calcium lactate (pentahydrate) (manufactured by Fuso Chemical Co., Ltd.) and 20 g of purified water were mixed and stirred at room temperature to prepare liquid B. (3) Solution A was covered with Saran Wrap and heated in a microwave (600W, 1 minute 40 seconds) and stirred thoroughly. It was then covered with Saran Wrap again and heated in a microwave (600W, 20 seconds). (4) Remove the Saran Wrap and add Solution B dropwise to Solution A while stirring, then mix thoroughly. Cover with Saran Wrap again and heat in a microwave oven (600W, 20 seconds) to remove any bubbles on the surface. (5) The mixture was filled into three stainless steel petri dishes (outer diameter 40 mm, height 15 mm), placed in Tupperware, and the lid was placed on the container and stored in a thermostatic chamber at 25°C for one day. The remainder was wrapped in plastic wrap, cooled in a water bath (tap water), and then stored in a thermostatic chamber at 25°C. (6) The product stored in a constant temperature cabinet at 25°C for one day was designated Preparation Example 3-1, and its moisture permeability, adhesiveness, and extensibility were evaluated using the filter paper method, and its hardness was measured according to the standards for foods for people with dysphagia. The evaluation results are shown in Table 5. The method conforming to the approval standards for foods for people with dysphagia was to fill a dissolved sample into a stainless steel container 40 mm in diameter and 15 mm in height, store it overnight at 25°C, and then compress it twice using a texture analyzer (Yamaden Co., Ltd.: Creep Meter RE2-3305C) with a silicon plunger 20 mm in diameter and 8 mm in height at a compression speed of 10 mm / s and a clearance of 5 mm, and the maximum load at this time was taken as the hardness of the sample.

[0069] [Preparation of Preparation Examples 3-2 to 3-21] Preparation Examples 2 to 21 were prepared using the same procedures as Preparation Example 1 according to the compositions shown in Table 5, and various evaluations were carried out. OF805C (manufactured by Unitec Foods Co., Ltd.) and LM-102AS-J (manufactured by Sansho Co., Ltd.) are pectins derived from citrus fruits. The evaluation results are shown in Table 5.

[0070] [Table 5]

[0071] The relationships between water permeability, adhesion, extensibility, and hardness based on Table 5 are shown in Figure 6. In Figure 6, the symbols "●", "◯", "△", and "×" indicate the evaluation results of adhesion for Preparation Examples 3-1 to 3-21, the numbers "2", "3", and "4" written adjacent to the symbols indicate the evaluation results of the corresponding extensibility, and "1700", "2500", "6000", and "7100" indicate the hardness (N / m 2 ) is shown. Regarding moisture permeability, Table 5 shows that the hardness of the jelly composition is 626 N / m 2 In the following cases, 7480N / m 2 In the above cases, the diameter of the water penetration circle after 3 minutes was less than 28 mm, the diameter of the water penetration circle after 10 minutes was less than 32 mm, and the diameter of the water penetration circle after 30 minutes was less than 36 mm. If the hardness of the jelly composition was too high or too low, the water permeability tended to decrease. On the other hand, if the hardness of the jelly composition was 627 to 7479 N / m 2 In all preparation examples within this range, the diameter of the water penetration circle after 3 minutes was 28 mm or more, the diameter of the water penetration circle after 10 minutes was 32 mm or more, and the diameter of the water penetration circle after 30 minutes was 36 mm or more, and not only was the water penetration circle excellent in a short time, but the excellent water penetration was maintained for at least 30 minutes. Furthermore, when the DE value was 40, the hardness was 1639 to 7019 N / m 2 In all preparation examples within the range, the water penetration circle diameter after 3 minutes was 30 mm or more, the penetration circle diameter after 10 minutes was 40 mm or more, and the penetration circle diameter after 30 minutes was 46 mm or more, and the superior water penetration was maintained for at least 30 minutes. Regarding extensibility, Table 5 shows that the lower the hardness of the jelly composition, the better the extensibility tends to be, except for those with extremely low hardness. 2 In all of the above preparation examples, the extensibility is 2 or more, which is excellent from the viewpoint of ease of uniform application, and the hardness is 2335 to 5760 N / m 2 In all preparation examples within this range, the extensibility was 3 or more, which was particularly excellent from the viewpoint of ease of uniform application. Furthermore, when the DE value was 30 to 40, the hardness was 2335 to 6158 N / m 2In all preparation examples within this range, the spreadability was 3 or more, which was particularly excellent in terms of ease of uniform application. Note that preparation examples 3-8, 3-13, and 3-15 were excluded from the evaluation of spreadability because the gel broke with a slight external force and behaved like a liquid. Regarding adhesion, as can be seen from Table 5, the higher the hardness of the jelly composition, the better the adhesion. 2 In all of the above preparation examples, the adhesion was △, 〇, or ●, which means that the adhesiveness remained excellent without peeling after application. The hardness was 2659 N / m 2 In all of the above preparation examples, the adhesion was rated as ◯ or ●, and the jelly composition (applied body) was particularly excellent in terms of remaining adhered without slipping after application. Furthermore, when the DE value was 30 to 40, the hardness was 2611 N / m 2 In all of the above preparation examples, the adhesion was rated as ◯ or ●, which was particularly excellent in that the entire jelly composition (applied body) remained adhered without slipping after application. From the above, the hardness of the jelly composition is 1640 to 7479 N / m 2 If the diameter of the water penetration circle after 3 minutes is 28 mm or more, the diameter of the water penetration circle after 10 minutes is 32 mm or more, and the diameter of the water penetration circle after 30 minutes is 36 mm or more, not only is it excellent in rapid water penetration in a short time, but the excellent water penetration is maintained for at least 30 minutes, the spreadability is 2 or more, it is excellent in terms of ease of uniform application, and the adhesion is △, ◯, or ●, it is excellent in terms of continuing to adhere without peeling after application. 2 Within this range, the diameter of the water penetration circle after 3 minutes was 28 mm or more, the diameter of the water penetration circle after 10 minutes was 32 mm or more, and the diameter of the water penetration circle after 30 minutes was 36 mm or more, meaning that not only was the composition excellent in rapid water penetration in a short period of time, but the excellent water penetration was maintained for at least 30 minutes, the spreadability was 3 or more, making it particularly excellent in terms of ease of uniform application, and the adhesion was ◯ or ●, making it particularly excellent in terms of the entire jelly composition (applied body) continuing to adhere without slipping after application. Also, when the DE value is 30 to 40, the hardness is 2611 to 6158 N / m 2 Within this range, the diameter of the water penetration circle after 3 minutes was 28 mm or more, the diameter of the water penetration circle after 10 minutes was 32 mm or more, and the diameter of the water penetration circle after 30 minutes was 36 mm or more, meaning that not only was the composition excellent in rapid water penetration in a short period of time, but the excellent water penetration was maintained for at least 30 minutes, the spreadability was 3 or more, making it particularly excellent in terms of ease of uniform application, and the adhesion was ◯ or ●, making it particularly excellent in terms of the entire jelly composition (applied body) continuing to adhere without slipping after application. Also, if the DE value is 40, the hardness is 1640 to 7479 N / m 2 In all preparation examples within the range, the diameter of the water penetration circle after 3 minutes is 30 mm or more, the diameter of the water penetration circle after 10 minutes is 40 mm or more, and the diameter of the water penetration circle after 30 minutes is 46 mm or more, and the water penetration property is particularly excellent and lasts for at least 30 minutes, and the extensibility is 2 or more, which is excellent from the viewpoint of ease of uniform application, and the adhesion is △, ◯, or ●, which is excellent from the viewpoint of continuing to adhere without peeling after application, and the hardness is 2611 to 7018 N / m 2 In all preparation examples within this range, the diameter of the water penetration circle after 3 minutes was 30 mm or more, the diameter of the water penetration circle after 10 minutes was 40 mm or more, and the diameter of the water penetration circle after 30 minutes was 46 mm or more, meaning that particularly excellent water penetration was maintained for at least 30 minutes, the spreadability was 3 or more, which was particularly excellent from the standpoint of ease of uniform application, and the adhesion was ◯ or ●, meaning that the entire jelly composition (applied body) continued to adhere without slipping after application.

[0072] Test Example 4 Dental hygienists administered the oral dry matter remover of the present invention to elderly people living in a special nursing home who actually had oral exfoliated epithelial membrane and tongue coating as part of professional oral care, and the effectiveness of removing oral exfoliated epithelial membrane and tongue coating was evaluated.

[0073] [Clinical evaluation] <Method for evaluating removal of oral exfoliated epithelial membrane and / or tongue coating> The subjects were nine elderly people requiring nursing care who had oral exfoliated epithelial membrane and / or tongue coating. Five dental hygienists performed the removal of oral exfoliated epithelial membrane and / or tongue coating using the professional oral care that they normally perform, and the five dental hygienists evaluated the removal of oral exfoliated epithelial membrane and / or tongue coating using the following evaluation criteria. The outline of the professional oral care is as follows: The oral dry matter remover of the present invention was applied to the fingertips, a toothbrush, an oral sponge brush, etc., and applied so as to cover the entire oral exfoliated epithelial membrane and / or tongue coating in the oral cavity of the subject, and after waiting 3 to 30 minutes for the oral exfoliated epithelial membrane and / or tongue coating to soften, it was removed using a toothbrush, oral sponge brush, etc.

[0074] <Evaluation criteria for removal of oral exfoliated epithelial membrane and / or tongue coating> A: Compared to the oral moisturizer (Viva Jel-ette; manufactured by Tokyo Giken Co., Ltd.) that had been used as a remover until now, it was able to remove oral exfoliated epithelial membrane and / or tongue coating very effectively. B: Compared to the oral moisturizer that had been used as a remover until now, oral exfoliated epithelial membrane and / or tongue coating were effectively removed. C: Compared to the oral moisturizer previously used as a remover, there was no change in the effect of removing oral exfoliated epithelial membrane and / or tongue coating.

[0075] [Preparation of Preparation Example 4] Pectin, maltitol, gluconic acid, and sodium citrate were dispersed and dissolved in 70 g of water while heating to 80°C to prepare liquid A. Next, calcium lactate was dissolved in 20 g of water and heated to 60°C to prepare liquid B. Liquid A was mixed with liquid B little by little while stirring, and finally, flavoring and sweetener were mixed in, and the total amount was adjusted with water. Each 20 g was filled into an aluminum sachet and sterilized by immersion in a bath at 80°C for 30 minutes to obtain an oral dry matter remover consisting of a jelly-like composition having the composition shown in Table 6. When the hardness was measured using the same method as in Test Example 3 in accordance with the approval standards for foods for people with swallowing difficulties, it was 2,122 N / m 2 The obtained oral dry matter remover was used to evaluate the effect of removing oral exfoliated epithelial membrane and tongue coating according to the above-mentioned evaluation method and criteria. The evaluation results are shown in Table 7.

[0076] [Table 6]

[0077] [Table 7]

[0078] When the hardness of a conventional oral moisturizer (Viva Jel-ette; manufactured by Tokyo Giken Co., Ltd.) was measured in accordance with the approval standards for foods for people with swallowing difficulties, as in Test Example 3, the hardness was 1538 N / m 2 As shown in Reference Example 1, the diameter of the water penetration circle of Viva Jelette measured by the filter paper method after 3 minutes was less than 28 mm, after 10 minutes was less than 32 mm, and after 30 minutes was less than 36 mm, indicating that the water penetration was lower than that of the jelly compositions of Test Examples 1 to 3. The results in Table 7 indicate that removal of oral exfoliated epithelial membrane and / or tongue coating using Preparation Example 4 was significantly more effective than conventional oral moisturizers in all subjects. Note that subject 6 did not have oral exfoliated epithelial membrane, so only tongue coating removal was evaluated. Thus, the effectiveness of the oral dry matter remover of the present invention in removing dry matter from the mouth was confirmed. These results confirm that the oral dry matter remover of the present invention is superior to conventional oral moisturizers in removing dry matter from the mouth, and that the effectiveness of removing dry matter from the mouth can be evaluated using the diameter of the water penetration circle measured by the filter paper method as an index.

[0079] Test Example 5 Dental hygienists administered the oral dry matter remover of the present invention or a conventional product (Oralpeace; manufactured by Foodcare Co., Ltd.) to dental patients who actually had oral exfoliated epithelial membrane and tongue coating in professional oral care, and the effectiveness of removing oral exfoliated epithelial membrane and tongue coating was evaluated.

[0080] [Clinical evaluation] <Method for evaluating removal of oral exfoliated epithelial membrane and / or tongue coating> Four dental patients with oral exfoliated epithelial membrane and / or tongue coating were used as subjects, and dental hygienists performed professional oral care similar to that in Test Example 4 to remove the oral exfoliated epithelial membrane and / or tongue coating, and the soaking time and removal time were measured.

[0081] [Preparation of Preparation Example 5] An oral dry matter remover consisting of a jelly-like composition having the composition shown in Table 8 below was obtained in the same manner as in Preparation Example 4, except that the filling amount was 10 g. When the hardness was measured in the same manner as in Test Example 3 in accordance with the approval standards for foods for people with dysphagia, it was found to be 2,400 N / m 2 The obtained oral dry matter remover was subjected to the above-mentioned clinical evaluation and evaluation of water permeability by the overlay filter paper method. The results of the clinical evaluation and the evaluation of water permeability are shown in Tables 9 and 10, respectively.

[0082] [Table 8]

[0083] [Table 9] Dry matter in the oral cavity: Dry matter in the oral cavity was evaluated according to the following criteria, with reference to the "buccal mucosa" item in the OHAT (Oral Health Assessment). 1: Healthy 2: Slightly changed 3: Changed 4: Slightly morbid 5: morbid Dryness: The dryness in the oral cavity was evaluated using the following criteria, with reference to the OHAT item "saliva." 1: Healthy 2: Slightly changed 3: Changed 4: Slightly morbid 5: morbid Plaque volume: The amount of plaque in the oral cavity was evaluated using the following criteria, with reference to the OHAT item "oral hygiene status." 1: Healthy 2: Slightly changed 3: Changed 4: Slightly morbid 5: morbid

[0084] [Table 10]

[0085] As a result, as shown in Table 9, the time required to soften the oral exfoliated epithelial membrane and / or tongue coating after application and the removal time were each reduced to half to one-quarter of those of the conventional product in all patients with different levels of oral dry matter, dryness, and plaque severity. The shortened softening time indicates that high moisture penetration into the oral dry matter was maintained compared to the conventional product, and the shortened removal time indicates that a greater amount of moisture penetrated into the oral dry matter compared to the conventional product. Furthermore, it was confirmed that the new product has both sufficient spreadability to apply the oral dry matter remover evenly and adhesiveness that allows it to adhere to the applied area throughout oral care without peeling off. Furthermore, the moisture permeability was evaluated by the filter paper method. As shown in Table 10, the conventional product did not show sufficient moisture penetration after 3 minutes, 10 minutes, or 30 minutes, whereas the composition of Preparation Example 5 showed a moisture penetration circle diameter of 28 mm or more after 3 minutes, a moisture penetration circle diameter of 32 mm or more after 10 minutes, and a moisture penetration circle diameter of 36 mm or more after 30 minutes. This confirmed that the excellent moisture permeability lasted for at least 30 minutes. From this, it was confirmed that the oral dry matter remover of the present invention has a superior effect of permeating moisture into the target and removing dry matter from the oral cavity compared to conventional oral care products. [Industrial Applicability]

[0086] The method for evaluating the water permeability of an oral preparation of the present invention can appropriately evaluate the water permeability in an oral dry matter remover, and the oral dry matter remover of the present invention is useful because it can effectively perform water penetration (softening) of oral dry matter such as oral exfoliated epithelial membrane and remove oral dry matter without causing bleeding, etc.

Claims

1. An oral dry matter remover comprising a jelly-like composition containing pectin, divalent metal ions, and water, A dry mouth remover with a pectin DE value of 20-50.

2. A mouth dry matter remover comprising a jelly-like composition containing pectin, a divalent metal ion, and water, The DE value of pectin is 20 to 50. An oral dry matter remover that exhibits moisture permeability such that, when measured by the overlay filter paper method under the following conditions, the diameter of the moisture penetration circle after 3 minutes is 28 mm or more, the diameter of the moisture penetration circle after 10 minutes is 32 mm or more, and / or the diameter of the moisture penetration circle after 30 minutes is 36 mm or more: Top-up filter paper method; The sample is tightly packed into an acrylic cylinder with an inner diameter of 23 mm, an outer diameter of 25 mm, and a height of 15 mm, the bottom of which is covered with paraffin film, and a cellulose filter paper (quantitative filter paper No. 5B (diameter 90 mm), manufactured by Advantec) is placed on top. The container is then left to stand in an incubator at 25°C. After a predetermined time (3 minutes, 10 minutes, 30 minutes) has elapsed, the longest and shortest diameters of the area where water has penetrated the filter paper (water penetration circle) are measured, and the average value is taken as the diameter of the water penetration circle.

3. The hardness of the jelly composition measured in accordance with the approval standards for foods for people with dysphagia (filling height: 15 mm, measurement temperature: 25°C) is 1640 to 7479 N / m 2 The oral dry matter remover according to claim 1 or 2,

4. 3. The oral dry matter remover according to claim 1, wherein the pectin content of the jelly composition is 0.5 to 3.0% by weight.

5. the divalent metal ion is a calcium ion, 3. The oral dry matter remover according to claim 1, wherein the calcium ion content of the jelly-like composition is 0.05 to 1.5% by weight in terms of calcium lactate.

6. The oral dry matter remover according to claim 1 or 2, which is applied to oral dry matter, oral mucosa and / or tooth surface.

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