Denture adhesive remover

Abstract

To provide a denture adhesive remover that can fully remove denture adhesive attached to dentures.SOLUTION: A denture adhesive remover comprises: at least one polar base selected from the group consisting of lower alcohols having 1 to 5 carbon atoms and polyhydric alcohols; and at least one metal compound selected from the group consisting of calcium chloride, calcium lactate, sodium chloride, magnesium chloride, zinc chloride, iron chloride, sodium carbonate, potassium fluoride, zinc fluoride, aluminum phosphate, sodium thiosulfate, anhydrous sodium sulfate, magnesium sulfate, aluminum sulfate, ferrous sulfate, sodium sulfite, calcium nitrate, magnesium nitrate, zinc nitrate, aluminum lactate, potassium acetate, calcium acetate, magnesium acetate, iron hexacyanoate, sodium hydroxide, potassium hydroxide, calcium oxide, aluminum oxide, aluminum ammonium sulfate, ammonium iron sulfate, potassium aluminum sulfate, and hydrates thereof. The concentration of the polar base is 1 to 99 mass% based on the total amount of the denture adhesive remover, and the concentration of the metal compound is 0.01 to 97 mass% based on the total amount of the denture adhesive remover.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a denture adhesive remover that removes denture adhesive adhering to the oral cavity or dentures. [Background technology]

[0002] Denture adhesives are sometimes used when fitting dentures into the mouth. Denture adhesives are applied to the surface of the denture base, which is the base of the dentures, to increase adhesion and adhesion to the gums and upper jaw, preventing the dentures from slipping when eating or speaking.

[0003] There are various types of denture adhesives, including cream, powder, and cushion types. Among them, "Polygrip (registered trademark)," which is classified as a cream type, has the top market share among denture adhesives and is sold in large quantities not only at dental clinics but also at general drugstores. Denture adhesives exert their adhesive properties by absorbing saliva in the oral cavity, improving the retention and stability of dentures. The main components that exert their adhesive properties are water-swellable, water-soluble polymer compounds such as "Na / Ca-Methoxyethylene Maleic Anhydride Copolymer Salt (PVMA Salt)" and "Carboxymethylcellulose (CMC)." Cream-type denture adhesives, including Polygrip, also contain hydrophobic ointment base ingredients such as "liquid paraffin" and "white petrolatum." The denture adhesive is retained in the oral cavity by a balance between the water absorption and viscosity of the water-soluble polymer and the resistance to leaching provided by the hydrophobic ointment base ingredients.

[0004] On the other hand, dentures and denture adhesives are not permanently retained in the oral cavity and must be periodically removed and cleaned. Current denture cleaning methods include mechanical cleaning using a brush or chemical cleaning using detergents. It is desirable that neither cleaning method will scratch or deform the dentures.

[0005] However, it is not easy to completely remove denture adhesive from the mouth or dentures. This is due to the fact that denture adhesive is highly adhesive and adheres strongly to the mouth and dentures. Applying too much force to remove it can lead to bleeding from the oral mucosa, pain for the patient, and damage or deformation of the dentures, making active cleaning difficult both practically and psychologically. Additionally, the complex structure of the mouth, including the teeth, dental neck, and unevenness of the dentures, makes it difficult to remove denture adhesive. In particular, in care settings, it is often the case that cooperation from denture wearers is not available or that it is difficult to take the time or effort to remove the denture adhesive, which can result in denture adhesive remaining in the mouth or on the dentures.

[0006] Bacteria can grow on the surface of denture adhesive remaining in the mouth or on dentures, forming a biofilm that can lead to denture stomatitis. It has also been suggested that oral bacteria may be involved in diseases such as bacterial endocarditis, aspiration pneumonia, and respiratory tract infections. Since many denture wearers are elderly and often in poor general health, they are more susceptible to these diseases. Therefore, an effective method for removing denture adhesive is needed.

[0007] Several denture adhesive removers are known. For example, Patent Document 1 describes that a denture adhesive remover containing 30 to 60% by weight of a lower alcohol, water, a thickener, and a surfactant can effectively remove denture adhesive and also has a bactericidal effect. However, the remover taught in Patent Document 1 cannot completely remove the denture adhesive from the denture even when force is applied after the remover is applied to the denture and denture adhesive. [Prior art documents] [Patent documents]

[0008] [Patent Document 1] JP 2020-164500 A Summary of the Invention [Problem to be solved by the invention]

[0009] An object of the present invention is to provide a denture adhesive remover that can sufficiently remove denture adhesive adhering to dentures. [Means for solving the problem]

[0010] To solve the above problems, the present inventors focused on the chemical properties of denture adhesives. They believed that chemically inhibiting the function of the water-swellable, water-soluble polymer compounds contained in denture adhesives and reducing their adhesiveness would enable effective removal of denture adhesive from dentures. They then discovered that a formulation containing a polar base and a specific metal compound could adequately remove denture adhesive from dentures.

[0011] The present invention was completed based on the above findings, and provides the following [1] to [9]. [1] A composition comprising a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) A hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. A denture adhesive remover which is a compound selected from the group consisting of: [2] The denture adhesive remover according to [1], wherein the inorganic acid is a compound selected from the group consisting of hydrochloric acid, carbonic acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, thiosulfuric acid, silicic acid, phosphoric acid, and hydrofluoric acid, and the organic acid is a compound selected from the group consisting of lactic acid, acetic acid, citric acid, gluconic acid, and hexacyanoic acid. [3] A denture adhesive remover according to [1] or [2], wherein the polar base is at least one selected from the group consisting of lower alcohols, higher alcohols, polyhydric alcohols, and glycol ethers. [4] A denture adhesive remover according to any one of [1] to [3], wherein the concentration of the polar base is 1 to 99% by mass based on the total amount of the denture adhesive remover. [5] A denture adhesive remover according to any one of [1] to [4], wherein the concentration of the metal compound is 0.01 to 97% by mass based on the total amount of the denture adhesive remover. [6] A denture adhesive remover according to any one of [1] to [5], wherein the content of the metal compound is 0.0005 to 20 parts by mass per part by mass of the polar base. [7] The denture adhesive remover according to any one of [1] to [6], further comprising a surfactant. [8] The denture adhesive remover according to [7], wherein the concentration of the surfactant is 0.01 to 20% by mass based on the total amount of the denture adhesive remover. [9] The denture adhesive remover according to [7] or [8], wherein the content of the surfactant is 0.01 to 20 parts by mass per 1 part by mass of the metal compound.

[10] The denture adhesive remover according to any one of [1] to [9], further comprising water.

[11] The denture adhesive remover according to

[10] , wherein the concentration of water is 0.001 to 90% by mass based on the total amount of the denture adhesive remover.

[12] A denture adhesive remover according to any one of [1] to

[11] , which is used to remove denture adhesive from dentures or the oral cavity.

[13] A composition comprising a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) A hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. Use of a composition comprising a compound selected from the group consisting of: as a denture adhesive remover or for producing a denture adhesive remover.

[14] A composition comprising a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) A hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. A method for removing denture adhesive comprising the step of applying to the denture adhesive an effective amount of a composition which is a compound selected from the group consisting of: [Effects of the Invention]

[0012] Conventional denture adhesive removers (hereinafter sometimes referred to as "removals") could not completely remove denture adhesive that had adhered to dentures even when strong force was applied, but the denture adhesive remover of the present invention chemically weakens the adhesion of denture adhesive, so that denture adhesive can be removed with less force or no force at all compared to conventional removers. Furthermore, the remover of the present invention acts on denture adhesive, changing its properties and removing it, so it can be removed not only from dentures but also from the oral mucosa. Furthermore, it is suitable for removing denture adhesive that has adhered or stuck to the oral mucosa because it can sufficiently remove denture adhesive without containing any irritating ingredients or ingredients that may have adverse effects on the human body. Conventional removers remove denture adhesive that has adhered to the oral mucosa by removing the denture from the oral cavity, but no removers exist that can remove denture adhesive that has adhered to the oral cavity. The remover of the present invention has high commercial value because it can effectively remove denture adhesive that has adhered to the oral cavity.

[0013] Many denture adhesives adhere strongly to the denture base and oral mucosa because the carboxyl group-containing polymer ionizes and becomes negatively charged when it comes into contact with water, causing electrostatic interaction with the denture base and oral mucosa. Although not limited to this mechanism, it is thought that the polar base of the remover of the present invention inhibits this electrostatic interaction, thereby weakening the adhesion of the denture adhesive to dentures. Although not limited to this mechanism, the carboxyl group-containing polymers contained in many denture adhesives ionize and become negatively charged when they come into contact with water, and thicken due to electrostatic repulsion and steric hindrance both within and between molecules; it is thought that the action of metal ions reduces the viscosity, making them more likely to peel off from dentures and the oral cavity. [Brief explanation of the drawings]

[0014] [Figure 1] 10 shows photographs of the inside of the oral cavity before and after wiping off denture adhesive adhering to the oral cavity using the formulation of Example 57. [Figure 2] 1 shows photographs of the inside of the oral cavity before and after wiping off denture adhesive adhering to the oral cavity using the preparation of Comparative Example 2. DETAILED DESCRIPTION OF THE INVENTION

[0015] The present invention will be described in detail below. The denture adhesive remover of the present invention comprises a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) A hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. The compound is selected from the group consisting of:

[0016] Polar base The polar base can be any polar base used in topical compositions, including lower alcohols (alcohols having 1 to 5 carbon atoms, preferably 2 to 4 carbon atoms), higher alcohols (aliphatic alcohols having 6 to 24 carbon atoms, preferably 12 to 18 carbon atoms), polyhydric alcohols, and glycol ethers. One or more polar bases can be used. The polar base may be in the form of a liquid, paste, powder, or flake at room temperature depending on the type and molecular weight, and the properties of the remover can be adjusted by using a combination of polar bases.

[0017] Examples of lower alcohols include methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, and amyl alcohol. Examples of higher alcohols include linear saturated higher alcohols such as hexyl alcohol, heptyl alcohol, capryl alcohol, nonyl alcohol, decyl alcohol, undecanol, lauryl alcohol, myristyl alcohol, cetanol, cetearyl alcohol, stearyl alcohol, arachidyl alcohol, and behenyl alcohol; linear unsaturated higher alcohols such as oleyl alcohol, linoleyl alcohol, and lignoceryl alcohol; and branched saturated higher alcohols such as hexyldecanol, isostearyl alcohol, octyldodecanol, and decyltetradecanol.

[0018] Examples of polyhydric alcohols include propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, isoprene glycol, polyethylene glycol, etc. The polyhydric alcohol may be a polymer such as polypropylene glycol or polyethylene glycol, or a non-polymer, but is preferably a polymer.

[0019] Examples of glycol ethers include ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether.

[0020] The polar base is preferably a lower alcohol or a polyhydric alcohol, and among these, ethanol, isopropyl alcohol, polypropylene glycol, and polyethylene glycol are preferred.

[0021] The concentration of the polar base can be 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more, based on the total amount of the remover. Within this range, denture adhesive can be effectively removed. The concentration of the polar base can be 99% by mass or less, 98% by mass or less, 97% by mass or less, 96% by mass or less, 95% by mass or less, 93% by mass or less, 90% by mass or less, 80% by mass or less, 70% by mass or less, or 60% by mass or less, based on the total amount of the remover. Within this range, a sufficient amount of other ingredients such as metal compounds can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.

[0022] The concentration of the polar base relative to the total amount of the remover is 1 to 99 mass%, 1 to 98 mass%, 1 to 97 mass%, 1 to 96 mass%, 1 to 95 mass%, 1 to 93 mass%, 1 to 90 mass%, 1 to 80 mass%, 1 to 70 mass%, 1 to 60 mass%; 5 to 99 mass%, 5 to 98 mass%, 5 to 97 mass%, 5 to 96 mass%, 5 to 95 mass%, 5 to 93 mass%, 5 to 90 mass%, 5 to 50 mass%. ~80% by mass, 5-70% by mass, 5-60% by mass; 10-99% by mass, 10-98% by mass, 10-97% by mass, 10-96% by mass, 10-95% by mass, 10-93% by mass, 10- 90% by mass, 10-80% by mass, 10-70% by mass, 10-60% by mass; 20-99% by mass, 20-98% by mass, 20-97% by mass, 20-96% by mass, 20-95% by mass, 20 ~93% by mass, 20-90% by mass, 20-80% by mass, 20-70% by mass, 20-60% by mass; 30-99% by mass, 30-98% by mass, 30-97% by mass, 30-96% by mass, 30-95% by mass, 30-93% by mass, 30-90% by mass, 30-80% by mass, 30-70% by mass, 30-60% by mass; 40-99% by mass, 40-98% by mass, 40-97% by mass , 40-96% by mass, 40-95% by mass, 40-93% by mass, 40-90% by mass, 40-80% by mass, 40-70% by mass, 40-60% by mass; 50-99% by mass, 50-98% by mass %, 50-97% by mass, 50-96% by mass, 50-95% by mass, 50-93% by mass, 50-90% by mass, 50-80% by mass, 50-70% by mass, and 50-60% by mass.

[0023] When the remover contains a polyhydric alcohol, its concentration can be 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more. Within this range, denture adhesive can be effectively removed. The polyhydric alcohol concentration can be 99% by mass or less, 98% by mass or less, 97% by mass or less, 96% by mass or less, 95% by mass or less, 93% by mass or less, 90% by mass or less, 80% by mass or less, 70% by mass or less, or 60% by mass or less, based on the total amount of the remover. Within this range, a sufficient amount of other ingredients such as metal compounds can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.

[0024] The concentration of the polyhydric alcohol relative to the total amount of the remover is 1 to 99 mass%, 1 to 98 mass%, 1 to 97 mass%, 1 to 96 mass%, 1 to 95 mass%, 1 to 93 mass%, 1 to 90 mass%, 1 to 80 mass%, 1 to 70 mass%, 1 to 60 mass%; 5 to 99 mass%, 5 to 98 mass%, 5 to 97 mass%, 5 to 96 mass%, 5 to 95 mass%, 5 to 93 mass%, 5 to 90 mass% , 5-80% by mass, 5-70% by mass, 5-60% by mass; 10-99% by mass, 10-98% by mass, 10-97% by mass, 10-96% by mass, 10-95% by mass, 10-93% by mass, 1 0-90 mass%, 10-80 mass%, 10-70 mass%, 10-60 mass%; 20-99 mass%, 20-98 mass%, 20-97 mass%, 20-96 mass%, 20-95 mass%, 20-93 mass%, 20-90 mass%, 20-80 mass%, 20-70 mass%, 20-60 mass%; 30-99 mass%, 30-98 mass%, 30-97 mass%, 30-96 mass% , 30-95% by mass, 30-93% by mass, 30-90% by mass, 30-80% by mass, 30-70% by mass, 30-60% by mass; 40-99% by mass, 40-98% by mass, 40-97% by mass %, 40-96 mass%, 40-95 mass%, 40-93 mass%, 40-90 mass%, 40-80 mass%, 40-70 mass%, 40-60 mass%; 50-99 mass%, 50-98 quality %, 50-97% by mass, 50-96% by mass, 50-95% by mass, 50-93% by mass, 50-90% by mass, 50-80% by mass, 50-70% by mass, and 50-60% by mass.

[0025] When the remover contains a lower alcohol, its concentration can be 5% by weight or more, 10% by weight or more, 20% by weight or more, 25% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more. Within this range, denture adhesive can be effectively removed. The concentration of the lower alcohol can be 40% by mass or less, 35% by mass or less, 30% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, or 5% by mass or less, based on the total amount of the remover. Within this range, a sufficient amount of other metal compounds can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect. In particular, a concentration of 10% by mass or less reduces irritation to the oral mucosa, making it even more suitable for use as an oral denture adhesive remover.

[0026] Examples of the concentration of the lower alcohol relative to the total amount of the remover include 5 to 40 mass%, 5 to 35 mass%, 5 to 30 mass%, 5 to 20 mass%, 5 to 15 mass%, 5 to 10 mass%; 10 to 40 mass%, 10 to 35 mass%, 10 to 30 mass%, 10 to 20 mass%, 10 to 15 mass%; 20 to 40 mass%, 20 to 35 mass%, 20 to 30 mass%; 25 to 40 mass%, 25 to 35 mass%, 25 to 30 mass%; 30 to 40 mass%, 30 to 35 mass%.

[0027] metal compounds Examples of metal compounds include salts of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one selected from inorganic acids, organic acids, and ammonia, or hydrates thereof. Examples of inorganic acids include hydrochloric acid, carbonic acid, phosphoric acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, thiosulfuric acid, silicic acid, and hydrofluoric acid. Examples of inorganic acid salts include phosphates, especially calcium phosphate. Examples of organic acids include lactic acid, acetic acid, citric acid, hexacyanoic acid, and gluconic acid. Examples of organic acid salts include stearates, especially calcium stearate. The metal compound may be an oxide of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. Magnesium oxide can be excluded from the oxides. Examples of the metal compound include hydroxides of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, and hydrates thereof. The metal compound may contain two or more types of metals and may also contain two or more types of counter ions of the metal ions, such as salts of the above metals with organic or inorganic acids and ammonia.

[0028] Examples of metal compounds include sodium chloride, sodium carbonate, sodium bicarbonate, sodium sulfate (e.g., anhydrous sodium sulfate), sodium sulfite, sodium thiosulfate, sodium acetate, sodium nitrite, sodium fluoride, sodium lactate, sodium acetate, sodium citrate, sodium gluconate, and sodium hydroxide; potassium chloride, potassium fluoride, potassium carbonate, potassium bicarbonate, potassium phosphate, potassium lactate, potassium acetate, potassium citrate, potassium gluconate, and potassium aluminum sulfate; calcium sulfate, calcium nitrate, calcium bicarbonate, calcium chloride, calcium oxide, calcium lactate, calcium citrate, and calcium acetate; magnesium chloride, magnesium sulfate, magnesium nitrate, magnesium citrate, and magnesium acetate; aluminum chloride, aluminum sulfate, aluminum phosphate, aluminum ammonium sulfate, aluminum nitrate, aluminum oxide, and aluminum lactate; zinc chloride, zinc fluoride, zinc sulfate, zinc nitrate, and zinc gluconate; iron chloride, iron sulfate, ammonium iron sulfate, and potassium iron hexacyanoate (e.g., potassium iron (III) hexacyanoate); and hydrates thereof. Among these, preferred metal compounds include sodium carbonate, sodium chloride, sodium sulfate (e.g., anhydrous sodium sulfate), sodium sulfite, sodium thiosulfate, sodium hydroxide; potassium fluoride, potassium hexacyanoferrate(III), potassium hydroxide, potassium aluminum sulfate, potassium acetate; calcium acetate, calcium chloride, calcium lactate, calcium oxide; magnesium chloride, magnesium nitrate, magnesium sulfate, magnesium acetate; aluminum lactate, aluminum sulfate, aluminum phosphate, ammonium aluminum sulfate, aluminum oxide; zinc fluoride; zinc chloride, zinc fluoride, zinc nitrate; iron chloride, iron sulfate, ammonium iron sulfate, potassium iron hexacyanoate (e.g., potassium iron(III) hexacyanoate); and hydrates thereof, which provide particularly excellent removal effects.

[0029] For example, if a compound that does not irritate the oral mucosa or has an unpleasant taste is selected from these compounds, it will be more suitable as an agent for removing denture adhesive from the oral cavity.

[0030] One or more metal compounds can be used. The metal compound used in the present invention can be a compound that generates metal ions (particularly, a certain amount of metal ions) in the remover or in the remover mixed with water during use.

[0031] The concentration of the metal compound in the remover can be 0.01% by mass or more, 0.05% by mass or more, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more, 5% by mass or more, 10% by mass or more, or 20% by mass or more, based on the total amount of the remover. Within this range, denture adhesive can be effectively removed. The concentration of the metal compound in the remover can be 97% by mass or less, 95% by mass or less, 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, 50% by mass or less, 40% by mass or less, or 30% by mass or less, based on the total amount of the remover. Within this range, a sufficient amount of a polar base or the like can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.

[0032] The concentration of the metal compound relative to the total amount of the remover is 0.01 to 97 mass%, 0.01 to 95 mass%, 0.01 to 90 mass%, 0.01 to 80 mass%, 0.01 to 70 mass%, 0.01 to 60 mass%, 0.01 to 50 mass%, 0.01 to 40 mass%, 0.01 to 30 mass%; 0.05 to 97 mass%, 0.05 to 95 mass%, 0.05 to 90 mass%, 0.05 to 80 mass%, 0.05 to 70 mass%, ... .05-60% by mass, 0.05-50% by mass, 0.05-40% by mass, 0.05-30% by mass; 0.1-97% by mass, 0.1-95% by mass, 0.1-90% by mass, 0.1-80% by mass, 0.1-70 Mass%, 0.1-60 mass%, 0.1-50 mass%, 0.1-40 mass%, 0.1-30 mass%; 0.5-97 mass%, 0.5-95 mass%, 0.5-90 mass%, 0.5-80 mass%, 0.5-7 0% by mass, 0.5-60% by mass, 0.5-50% by mass, 0.5-40% by mass, 0.5-30% by mass; 1-97% by mass, 1-95% by mass, 1-90% by mass, 1-80% by mass, 1-70% by mass, 1-60 Mass%, 1-50 mass%, 1-40 mass%, 1-30 mass%; 5-97 mass%, 5-95 mass%, 5-90 mass%, 5-80 mass%, 5-70 mass%, 5-60 mass%, 5-50 mass%, 5-40 quality Amount%, 5~30 mass%; 10~97 mass%, 10~95 mass%, 10~90 mass%, 10~80 mass%, 10~70 mass%, 10~60 mass%, 10~50 mass%, 10~40 mass%, 10~30 quality Amount %: 20-97% by mass, 20-95% by mass, 20-90% by mass, 20-80% by mass, 20-70% by mass, 20-60% by mass, 20-50% by mass, 20-40% by mass, and 20-30% by mass.

[0033] The content of the metal compound in the remover can be at least 0.0005 parts by weight, at least 0.001 parts by weight, at least 0.005 parts by weight, at least 0.01 parts by weight, at least 0.05 parts by weight, or at least 0.1 parts by weight per part by weight of the polar base. Within this range, denture adhesive can be effectively removed. The content of the metal compound in the remover can be 20 parts by weight or less, 10 parts by weight or less, 8 parts by weight or less, 5 parts by weight or less, 3 parts by weight or less, 2 parts by weight or less, 1 part by weight or less, or 0.5 parts by weight or less per part by weight of the polar base. Within this range, a sufficient amount of other polar bases can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.

[0034] The ratio of the content of the metal compound to 1 part by mass of the polar base is 0.0005 to 20 parts by mass, 0.0005 to 10 parts by mass, 0.0005 to 8 parts by mass, 0.0005 to 5 parts by mass, 0.0005 to 3 parts by mass, 0.0005 to 2 parts by mass, 0.0005 to 1 part by mass, 0.0005 to 0.5 parts by mass, or 0.001 to 20 parts by mass. , 0.001-10 parts by mass, 0.001-8 parts by mass, 0.001-5 parts by mass, 0.001-3 parts by mass, 0.001-2 parts by mass, 0.001-1 parts by mass, 0. 001~0.5 parts by mass; 0.005~20 parts by mass, 0.005~10 parts by mass, 0.005~8 parts by mass, 0.005~5 parts by mass, 0.005~3 parts by mass, 0.0 05-2 parts by mass, 0.005-1 parts by mass, 0.005-0.5 parts by mass; 0.01-20 parts by mass, 0.01-10 parts by mass, 0.01-8 parts by mass, 0.01-5 Parts by mass, 0.01-3 parts by mass, 0.01-2 parts by mass, 0.01-1 parts by mass, 0.01-0.5 parts by mass; 0.05-20 parts by mass, 0.05-10 parts by mass, 0.0 5-8 parts by mass, 0.05-5 parts by mass, 0.05-3 parts by mass, 0.05-2 parts by mass, 0.05-1 parts by mass, 0.05-0.5 parts by mass; 0.1-20 parts by mass, 0 Examples include .1 to 10 parts by mass, 0.1 to 8 parts by mass, 0.1 to 5 parts by mass, 0.1 to 3 parts by mass, 0.1 to 2 parts by mass, 0.1 to 1 part by mass, and 0.1 to 0.5 parts by mass.

[0035] When the metal compound is a hydrate, the concentration and content of the metal compound are those excluding water of hydration.

[0036] Polar bases and metal compounds also fall under the category of "polar bases" and "metal compounds" of the present invention when they are incorporated for purposes other than releasing denture adhesive, such as as additives as described below.

[0037] In order for the remover of the present invention to be effective, the presence of water is required based on its principle, but the denture adhesive remover of the present invention may or may not contain water. If it contains water, preparation before use is not required and it can be applied directly to the oral cavity or dentures, resulting in a formulation that is highly convenient for use. If it does not contain water, preparation before use by adding water is required, but by not including water, the weight of the formulation itself can be reduced, resulting in a formulation that is highly convenient for distribution. When water is contained, its concentration can be 0.001% by mass or more, 0.01% by mass or more, 0.1% by mass or more, 1% by mass or more, 5% by mass or more, 10% by mass or more, 20% by mass or more, 30% by mass or more, or 40% by mass or more, based on the total amount of the remover. Within this range, the formulation can fully exert its denture adhesive removing effect without adding water from outside. The water concentration can be 90% by mass or less, 80% by mass or less, 70% by mass or less, 60% by mass or less, or 50% by mass or less, based on the total amount of the remover. Within this range, sufficient amounts of metal compound and polar base can be blended, resulting in a formulation that can fully demonstrate the denture adhesive removal effect.

[0038] The concentrations of water relative to the total amount of the remover are 0.001 to 90 mass%, 0.001 to 80 mass%, 0.001 to 70 mass%, 0.001 to 60 mass%, 0.001 to 50 mass%; 0.01 to 90 mass%, 0.01 to 80 mass%, 0.01 to 70 mass%, 0.01 to 60 mass%, 0.01 to 50 mass%; 0.1 to 90 mass%, 0.1 to 80 mass%, 0.1 to 70 mass%, 0.1 to 60 mass%, 0.1 to 50 mass%; 1 to 90 mass%, 1 to 80 mass%, 1 to 70 mass%, 1 to 60 mass%, 1 to 50 mass%; 5 ~90% by mass, 5-80% by mass, 5-70% by mass, 5-60% by mass, 5-50% by mass; 10-90% by mass, 10-80% by mass, 10-70% by mass, 10-60% by mass, 10-50% by mass; 20-90% by mass, 20-80% by mass, 20-70% by mass, 2 Examples include 0-60% by mass, 20-50% by mass; 30-90% by mass, 30-80% by mass, 30-70% by mass, 30-60% by mass, 30-50% by mass; 40-90% by mass, 40-80% by mass, 40-70% by mass, 40-60% by mass, and 40-50% by mass.

[0039] When the denture adhesive remover of the present invention contains water, the content of water may be at least 0.001 part by mass, at least 0.01 part by mass, at least 0.05 part by mass, at least 0.1 part by mass, at least 1 part by mass, at least 5 parts by mass, at least 10 parts by mass, at least 30 parts by mass, at least 50 parts by mass, or at least 80 parts by mass per part by mass of the polar base. Within this range, the formulation will suppress irritation to the oral mucosa caused by the polar base and will exhibit a sufficient denture adhesive removal effect. The water content can be 95 parts by mass or less, 90 parts by mass or less, 80 parts by mass or less, 70 parts by mass or less, 60 parts by mass or less, 50 parts by mass or less, 30 parts by mass or less, 10 parts by mass or less, 5 parts by mass or less, or 3 parts by mass or less per part by mass of polar base. Within these ranges, sufficient amounts of metal compound and polar base can be blended, resulting in a formulation that can fully exhibit the denture adhesive removal effect.

[0040] The ratio of the water content to 1 part by mass of the polar base is 0.001 to 95 parts by mass, 0.001 to 90 parts by mass, 0.001 to 80 parts by mass, 0.001 to 70 parts by mass, 0.001 to 60 parts by mass, 0.001 to 50 parts by mass, 0.001 to 30 parts by mass, 0.001 to 10 parts by mass, 0.001 to 5 parts by mass, 0.001 to 3 parts by mass; 0.01 to 95 parts by mass, 0.01 to 90 parts by mass, 0.01 to 80 parts by mass, 0.01 to 70 parts by mass, 0.01 to 60 parts by mass Parts by weight, 0.01-50 parts by weight, 0.01-30 parts by weight, 0.01-10 parts by weight, 0.01-5 parts by weight, 0.01-3 parts by weight; 0.05-95 parts by weight, 0.05-90 parts by weight, 0.05-80 parts by weight, 0.05-70 parts by weight parts, 0.05-60 parts by mass, 0.05-50 parts by mass, 0.05-30 parts by mass, 0.05-10 parts by mass, 0.05-5 parts by mass, 0.05-3 parts by mass; 0.1-95 parts by mass, 0.1-90 parts by mass, 0.1-80 parts by mass, 0.1 ~70 parts by mass, 0.1-60 parts by mass, 0.1-50 parts by mass, 0.1-30 parts by mass, 0.1-10 parts by mass, 0.1-5 parts by mass, 0.1-3 parts by mass; 1-95 parts by mass, 1-90 parts by mass, 1-80 parts by mass, 1-70 parts by mass, 1 ~60 parts by mass, 1-50 parts by mass, 1-30 parts by mass, 1-10 parts by mass, 1-5 parts by mass, 1-3 parts by mass; 5-95 parts by mass, 5-90 parts by mass, 5-80 parts by mass, 5-70 parts by mass, 5-60 parts by mass, 5-50 parts by mass, 5-30 parts by mass Parts by weight, 5-10 parts by weight; 10-95 parts by weight, 10-90 parts by weight, 10-80 parts by weight, 10-70 parts by weight, 10-60 parts by weight, 10-50 parts by weight, 10-30 parts by weight; 30-95 parts by weight, 30-90 parts by weight, 30-80 parts by weight parts by weight, 30-70 parts by weight, 30-60 parts by weight, 30-50 parts by weight; 50-95 parts by weight, 50-90 parts by weight, 50-80 parts by weight, 50-70 parts by weight, 50-60 parts by weight; 80-95 parts by weight, and 80-90 parts by weight.

[0041] When the remover of the present invention does not contain water, it may be prepared at the time of use so that it contains water at the above concentration or content.

[0042] Optional ingredients In addition to the polar base, metal compound, and optionally water, the denture adhesive remover of the present invention may contain additives depending on the formulation, provided that the effects of the present invention are not impaired. Examples of additives include surfactants, pH adjusters, bactericidal components or preservatives, humectants, stabilizers, thickeners, sweeteners, and flavorings. One or more additives may be used.

[0043] As the surfactant, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, naturally occurring surfactants, organic solvents that function as solubilizers, and the like can be used. The cleaning effect of surfactants can emulsify hydrophobic ointment base components such as liquid paraffin and white petrolatum contained in denture adhesives, further increasing the efficiency of removing the denture adhesive.

[0044] Examples of anionic surfactants include higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfates such as POE-lauryl triethanolamine sulfate and sodium POE-lauryl sulfate; higher fatty acid amide sulfonates such as sodium stearoyl methyl taurate, sodium myristoyl methyl taurate, sodium cocoyl methyl taurate, and sodium cocoyl methyl taurate; POE-alkyl ether phosphates and salts thereof such as sodium POE-oleyl ether phosphate, sodium POE-cetyl ether phosphate, and POE-stearyl ether phosphate; phosphate esters and salts thereof such as potassium cetyl phosphate and cetyl phosphate; sulfosuccinates such as sodium di-2-ethylhexyl sulfosuccinate; alkyl benzene sulfonates such as sodium linear dodecyl benzene sulfonate; higher fatty acid ester sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; and N-acyl glutamates such as monosodium lauroyl glutamate, sodium stearoyl glutamate, and sodium myristoyl glutamate.

[0045] Examples of cationic surfactants include fatty acid amidoamines such as stearamidopropyl dimethylamine and behenamidopropyl dimethylamine; monoalkyl quaternary ammonium salts such as cetrimonium chloride, steartrimonium chloride, behentrimonium chloride, steartrimonium bromide, cetrimonium methosulfate and behentrimonium methosulfate; monoalkyl ether quaternary ammonium salts such as stearoxypropyltrimonium chloride and behenyl PG trimonium chloride; dialkyl quaternary ammonium salts such as distearyldimonium chloride, dicocodimonium chloride, dialkyl (12 to 18 carbon atoms) dimonium chloride and quaternium-18; dialkyl ester quaternary ammonium salts such as dicocoyl ethyl hydroxyethylmonium methosulfate and distearoyl ethyl hydroxyethylmonium methosulfate; and benzalkonium quaternary ammonium salts such as benzalkonium chloride and benzethonium chloride.

[0046] Examples of amphoteric surfactants include carbobetaine, sulfobetaine, imidazolinium betaine, and amidobetaine.

[0047] Nonionic surfactants include POE-2-decyltetradecyl alcohol, POE-alkyl ethers such as polyoxyethylene oleyl ether and polyoxyethylene cetyl ether; sorbitan fatty acid esters such as sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monooleate, and sorbitan sesquioleate; POE(20) sorbitan monoisostearate, POE(20) sorbitan monooleate, POE(20) sorbitan monostearate, and POE(20) sorbitan monococonut oil fatty acid esters. POE-sorbitan fatty acid esters such as 0) sorbitan and POE(80) sorbitan laurate; glycerin fatty acid esters such as glyceryl monostearate and glyceryl oleate; POE-glycerin fatty acid esters such as polyoxyethylene glyceryl stearate and polyoxyethylene glyceryl trioleate; POE-dihydrocholesterol ester; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-6 ... POE-hydrogenated castor oils such as hydroxyethylene hydrogenated castor oil 80; POE castor oils such as POE(3) castor oil and POE(20) castor oil; POE-hydrogenated castor oil fatty acid esters such as POE-hydrogenated castor oil isostearate; POE-alkylaryl ethers; glycerin alkyl ethers such as cumyl alcohol, batyl alcohol, and selachyl alcohol; POE-glycerin alkyl ethers such as POE-monostearyl glyceryl ether; POE fatty acid esters such as polyoxyl stearate; sucrose palmitate, sucrose stearate Examples of suitable fatty acid esters include phosphate esters, sucrose oleate, sucrose isostearate, sucrose linoleate, and sucrose linolenate; polyethylene glycol fatty acid esters such as polyethylene glycol dioleate; and polyglycerin fatty acid esters such as alkyl polyglycosides, diglyceryl monostearate, diglyceryl monoisostearate, decaglyceryl monostearate, decaglyceryl monooleate, decaglyceryl pentaoleate, and hexaglyceryl polyricinoleate.

[0048] Examples of naturally occurring surfactants include lecithin, hydrogenated lecithin, saponin, sodium surfactin, and bile acid.

[0049] Examples of organic solvents include POE·POP alkyl ethers (the alkyl group has 10 to 26 carbon atoms) (POE·POP cetyl ethers such as POE(20)POP(4) cetyl ether, POE·POP decyltetradecyl ethers such as POE(30)POP(6) decyltetradecyl ether, POE·POP decyltetradecyl ethers such as POE(20)POP(6) decyltetradecyl ether, etc.); POE alkyl ethers (the alkyl group has 10 to 26 carbon atoms) (POE oleyl ethers such as POE(50) oleyl ether, POE oleyl ethers such as POE(20) oleyl ether, POE lauryl ethers such as POE(25) lauryl ether); and solubilizers such as lauromacrogol.

[0050] When the remover of the present invention contains a surfactant, its concentration can be at least 0.01%, 0.1%, 1%, 3%, 5%, or 10% by weight of the total amount of the remover. Within this range, denture adhesive can be removed more effectively. Furthermore, when the remover of the present invention contains a surfactant, its concentration can be 20% by mass or less, 10% by mass or less, 8% by mass or less, 6% by mass or less, or 4% by mass or less, based on the total amount of the remover. Generally, an excessive amount of surfactant can actually reduce the cleaning effect of the preparation, but within this range, the cleaning effect of the preparation is not reduced, and sufficient amounts of metal compound and polar base can be incorporated, resulting in a preparation that can fully demonstrate its denture adhesive removing effect.

[0051] Examples of the concentration of the surfactant relative to the total amount of the remover include 0.01 to 20 mass%, 0.01 to 10 mass%, 0.01 to 8 mass%, 0.01 to 6 mass%, 0.01 to 4 mass%; 0.1 to 20 mass%, 0.1 to 10 mass%, 0.1 to 8 mass%, 0.1 to 6 mass%, 0.1 to 4 mass%; 1 to 20 mass%, 1 to 10 mass%, 1 to 8 mass%, 1 to 6 mass%, 1 to 4 mass%; 3 to 20 mass%, 3 to 10 mass%, 3 to 8 mass%, 3 to 6 mass%, 3 to 4 mass%; 5 to 20 mass%, 5 to 10 mass%, 5 to 8 mass%, 5 to 6 mass%; and 10 to 20 mass%.

[0052] When the remover of the present invention contains a surfactant, the content thereof can be at least 0.001 part by weight, at least 0.005 part by weight, at least 0.01 part by weight, at least 0.05 part by weight, at least 0.1 part by weight, at least 1 part by weight, at least 5 parts by weight, or at least 10 parts by weight per part by weight of the polar base. Within this range, denture adhesive can be effectively removed. The content of the surfactant can be 40 parts by mass or less, 30 parts by mass or less, 25 parts by mass or less, 20 parts by mass or less, 10 parts by mass or less, 5 parts by mass or less, 1 part by mass or less, or 0.5 parts by mass or less per part by mass of the polar base. Generally, an excessive amount of surfactant can actually reduce the cleaning effect of the preparation, but if the content is within this range, the cleaning effect of the preparation will not be reduced and sufficient amounts of metal compound and polar base can be incorporated, resulting in a preparation that can fully demonstrate its denture adhesive removal effect.

[0053] The content ratio of the surfactant relative to 1 part by mass of the polar base is 0.001 to 40 parts by mass, 0.001 to 30 parts by mass, 0.001 to 25 parts by mass, 0.001 to 20 parts by mass, 0.001 to 10 parts by mass, 0.001 to 5 parts by mass, 0.001 to 1 part by mass, 0.001 to 0.5 parts by mass; 0.005 to 40 parts by mass, 0.005 to 30 parts by mass, 0.0 05-25 parts by mass, 0.005-20 parts by mass, 0.005-10 parts by mass, 0.005-5 parts by mass, 0.005-1 parts by mass, 0.005-0.5 parts by mass; 0.01-40 parts by mass Parts by weight, 0.01~30 parts by weight, 0.01~25 parts by weight, 0.01~20 parts by weight, 0.01~10 parts by weight, 0.01~5 parts by weight, 0.01~1 parts by weight, 0.01~0.5 parts by weight Parts; 0.05-40 parts by mass, 0.05-30 parts by mass, 0.05-25 parts by mass, 0.05-20 parts by mass, 0.05-10 parts by mass, 0.05-5 parts by mass, 0.05-1 parts by mass parts, 0.05-0.5 parts by mass; 0.1-40 parts by mass, 0.1-30 parts by mass, 0.1-25 parts by mass, 0.1-20 parts by mass, 0.1-10 parts by mass, 0.1-5 parts by mass, 0.1 ~1 part by mass, 0.1-0.5 parts by mass; 1-40 parts by mass, 1-30 parts by mass, 1-25 parts by mass, 1-20 parts by mass, 1-10 parts by mass, 1-5 parts by mass; 5-40 parts by mass, 5-30 parts by mass Parts by weight, 5 to 25 parts by weight, 5 to 20 parts by weight, 5 to 10 parts by weight, 1 to 5 parts by weight; 10 to 40 parts by weight, 10 to 30 parts by weight, 10 to 25 parts by weight, and 10 to 20 parts by weight.

[0054] When the remover of the present invention contains a surfactant, the content thereof can be at least 0.01 part by mass, at least 0.05 part by mass, at least 0.1 part by mass, at least 0.15 part by mass, at least 0.5 part by mass, at least 0.8 part by mass, or at least 1 part by mass per part by mass of the metal compound. Within this range, denture adhesive can be effectively removed. The content of the surfactant can be 20 parts by mass or less, 10 parts by mass or less, 5 parts by mass or less, or 3 parts by mass or less per part by mass of the metal compound. Generally, an excessive amount of surfactant can actually reduce the cleaning effect of the preparation, but within this range, the cleaning effect of the preparation is not reduced and sufficient amounts of the metal compound and polar base can be incorporated, resulting in a preparation that can fully demonstrate its denture adhesive removal effect.

[0055] The content ratio of the surfactant relative to 1 part by mass of the metal compound is 0.01 to 20 parts by mass, 0.01 to 10 parts by mass, 0.01 to 5 parts by mass, 0.01 to 3 parts by mass; 0.05 to 20 parts by mass, 0.05 to 10 parts by mass, 0.05 to 5 parts by mass, 0.05 to 3 parts by mass; 0.1 to 20 parts by mass, 0.1 to 10 parts by mass, 0.1 to 5 parts by mass, 0.1 to 3 parts by mass; 0.15-20 parts by mass, 0.15-10 parts by mass, 0.15-5 parts by mass, 0.15-3 parts by mass; 0.5-20 parts by mass, 0.5-10 parts by mass, 0.5-5 parts by mass, 0.5-3 parts by mass Parts: 0.8 to 20 parts by weight, 0.8 to 10 parts by weight, 0.8 to 5 parts by weight, 0.8 to 3 parts by weight; 1 to 20 parts by weight, 1 to 10 parts by weight, 1 to 5 parts by weight, and 1 to 3 parts by weight.

[0056] Examples of pH adjusters include organic acids and salts thereof such as acetic acid, oxalic acid, maleic acid, fumaric acid, malonic acid, lactic acid, tartaric acid, citric acid, benzoic acid, methanesulfonic acid, succinic acid, malic acid, ascorbic acid, adipic acid, and benzoic acid; inorganic acids and salts thereof such as phosphoric acid, hydrochloric acid, nitric acid, and carbonic acid; inorganic bases such as potassium hydroxide and sodium hydroxide; and organic bases such as triethanolamine, diisopropanolamine, and triisopropanolamine.

[0057] Examples of antiseptic ingredients or preservatives include glycerin fatty acid esters; parabens such as isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, butyl parahydroxybenzoate, propyl parahydroxybenzoate, and sodium propyl parahydroxybenzoate; benzoic acids such as benzoic acid, sodium benzoate, and benzyl benzoate; quaternary ammonium salts such as benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetylpyridinium chloride, tetraethylammonium bromide, and didecyldimethylammonium chloride; ethylenediaminetetraacetate; chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride; isopropylmethylphenol; and hinokitiol.

[0058] Humectants include glycerin, sorbitol, and the like.

[0059] The stabilizer may include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, and the like.

[0060] Examples of thickeners include guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, macrogol, and cellulose-based thickeners (methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, etc.).

[0061] Sweeteners include saccharin sodium, stevia extract, sucralose, palatinose, maltitol, xylitol, trehalose, and arabitol.

[0062] The flavorings include various essential oils, essential oil components such as menthol, and compound flavors.

[0063] The remover of the present invention can be in the form of a solid such as a powder, tablet, or gum, a liquid (including a viscous fluid form), or a paste. Furthermore, a liquid or paste preparation can be soaked in a nonwoven fabric or the like to form a sheet. When used as a remover for the oral cavity, as described below, it is preferable to use a gum, paste, or sheet to prevent accidental aspiration in elderly people. Dry solid preparations such as powders and tablets can be prepared as ready-to-use preparations that are mixed with water, etc., at the time of use. In the case of ready-to-use preparations, the composition of the remover of the present invention described above is the composition of the finished preparation that is mixed with water, etc., at the time of use.

[0064] The remover of the present invention can be a denture adhesive remover for removing denture adhesive from dentures. It can also be a denture adhesive remover for removing denture adhesive from the oral cavity (oral mucosa), i.e., an oral denture adhesive remover. Denture adhesive removers are also sometimes called denture adhesive cleaners.

[0065] The amount of the remover of the present invention used can be 1.5 to 15 g, preferably 2 to 10 g, per 1 g of denture adhesive. After applying the remover of the present invention to the denture adhesive (by coating, spraying, pasting, etc.), the denture adhesive can be removed from the denture and oral cavity by, for example, moving the denture adhesive with your hands or rubbing it with your fingers, a brush, or a cloth. If the remover of the present invention is left to stand for up to 60 seconds, preferably 5 to 10 seconds, after applying it to the denture adhesive, the adhesive strength of the denture adhesive is more effectively reduced, making it easier to remove.

[0066] The present invention encompasses a method for removing a denture adhesive (e.g., a method for removing a denture adhesive from a denture or oral cavity) comprising applying to the denture adhesive a composition comprising a polar base and at least one metal compound. In this method, the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) A hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. The compound is selected from the group consisting of: The metal compound may contain two or more types of metals and may also contain two or more types of counter ions of the metal ions, such as salts of the above metals with organic or inorganic acids and ammonia. In this method, the denture adhesive can be attached to the denture or the oral cavity. The composition and properties of the composition containing the polar base and the metal compound are as described above for the denture adhesive remover of the present invention. The amount of the composition containing a polar base and at least one metal compound used should be an effective amount, preferably 1.5 to 15 g, and more preferably 2 to 10 g, per 1 g of denture adhesive. The remover of the present invention can be applied to a denture adhesive by coating, spraying, or pasting. After the application step, a step of allowing the applied denture adhesive to stand can be included, which can be for up to 60 seconds, preferably 5 to 10 seconds. A further step can be included in which the denture adhesive is removed from the denture or oral cavity by applying force to it. [Example]

[0067] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0068] (1) Preparation of denture adhesive remover Liquid to powder preparations having the compositions shown in Tables 1 to 7 were prepared by mixing the components. [Table 1] [Table 2] [Table 3] [Table 4] [Table 5] [Table 6] [Table 7]

[0069] (2) No. 1 in denture adhesive remover performance evaluation The performance of denture adhesive removers was evaluated by simulating the conditions of dentures and the oral cavity. 0.1 g of denture adhesive (product name: Additive-Free New Polygrip) was applied to a 70 x 70 mm, 2 mm thick glass plate and immersed in tap water. After one minute, the plate was removed, and another glass plate of the same size was placed on top of the denture adhesive. A 1 kg weight was then placed on top of the plate to apply a load. After 10 seconds, the weight was removed, and one of the glass plates was peeled off to obtain the sample. 1 g of each formulation from the Examples or Comparative Examples was applied to the denture adhesive and its surrounding area. Immediately afterwards, the denture adhesive was rubbed with a finger and the degree of release was scored on a 5-point scale according to the following criteria. A score of 2 or higher was considered "pass," indicating that removal was sufficiently effective and efficient. 0: Not at all 1: When force is applied, the surface of the denture adhesive moves, but it cannot be peeled off. 2: The surface of the denture adhesive moves with a light force, but most of it can be removed with a strong force. 3: If you apply strong force, it can be completely peeled off. 4: Can be completely peeled off with light force

[0070] The evaluation results are shown in Tables 1 to 7. The formulation of Comparative Example 1, which did not contain a polar base, the formulations of Comparative Examples 2 to 4, which contained calcium stearate, magnesium oxide, and calcium phosphate as metal compounds, respectively, and the formulation of Comparative Example 5, which did not contain a metal compound, were unable to remove the denture adhesive. In contrast, the formulations of Examples 1 to 57 were able to remove the denture adhesive.

[0071] The remover of the present invention acts on the denture adhesive, changing its physical properties and thereby promoting the release of the denture adhesive, so it is reasonably expected that if it can be removed from a glass plate, it can also be removed from the oral cavity. Furthermore, some of the example formulations have an irritating or unpleasant taste and are therefore not suitable for removing denture adhesive from the oral cavity, but are useful for removing denture adhesive from dentures.

[0072] (3) Denture adhesive remover performance evaluation No. 2 The denture adhesive removal performance in the human oral cavity was evaluated for the formulations of Examples and Comparative Examples that were judged to be suitable for use in the oral cavity from the standpoint of irritation, taste, etc. (Examples and Comparative Examples with irritation to the oral mucosa and unpleasant taste rated as either 0 or 0 in Tables 1 to 7). 0.2 g of denture adhesive (product name: Additive-free New Polygrip) colored with Blue No. 1 was applied to the palate of one subject, and a splint made to fit the subject's palate was placed over it. Ten minutes after application, the splint was removed, and a nonwoven fabric soaked in 1 g of the formulation of each Example or Comparative Example was wrapped around a finger and used to wipe the palate in an attempt to remove any denture adhesive remaining on the palate. The wiping time was 30 seconds, and those that were able to remove the adhesive were evaluated as "suitable." The formulation of Comparative Example 2 was composed of ingredients that did not cause irritation or an unpleasant taste. The results are shown in Tables 1 to 7. When the formulations of the Examples, which were rated as either good or fair for irritation to the oral mucosa and unpleasant taste, were used, denture adhesive adhering to the oral cavity could be completely removed without damaging the oral cavity. Figure 1 shows the condition of the oral cavity before and after wiping with the formulation of Example 57. Similar conditions were observed with the formulations of the other Examples. Figure 2 also shows the condition of the oral cavity before and after wiping with the formulation of Comparative Example 2. When the formulation of Comparative Example 2 was used, the adhesiveness of the denture adhesive was not reduced, and it was not sufficiently removed by wiping for 30 seconds, leaving a thin layer of denture adhesive remaining in the oral cavity. [Industrial Applicability]

[0073] The remover of the present invention chemically reduces the adhesiveness of denture adhesive using a polar base and a metal compound, thereby enabling it to effectively and efficiently remove denture adhesive from the oral cavity and dentures. Furthermore, because it can be prepared using general-purpose ingredients that are suitable for oral use and have little irritation or unpleasant taste, it can be used in a wide range of fields, including dental care and nursing care, making it highly valuable as a commercial product.

Claims

[Claim 1] A denture adhesive remover comprising at least one polar base selected from the group consisting of lower alcohols having 1 to 5 carbon atoms and polyhydric alcohols, and at least one metal compound selected from the group consisting of calcium chloride, calcium lactate, sodium chloride, magnesium chloride, zinc chloride, iron chloride, sodium carbonate, potassium fluoride, zinc fluoride, aluminum phosphate, sodium thiosulfate, anhydrous sodium sulfate, magnesium sulfate, aluminum sulfate, iron sulfate, sodium sulfite, calcium nitrate, magnesium nitrate, zinc nitrate, aluminum lactate, potassium acetate, calcium acetate, magnesium acetate, iron hexacyanoate, sodium hydroxide, potassium hydroxide, calcium oxide, aluminum oxide, aluminum ammonium sulfate, ammonium iron sulfate, potassium aluminum sulfate, and hydrates thereof, wherein the concentration of the polar base is 1 to 99% by mass, based on the total amount of the denture adhesive remover, and the concentration of the metal compound is 0.01 to 97% by mass, based on the total amount of the denture adhesive remover.

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