Oil-in-detergent type emulsion composition

Abstract

To provide a composition that exhibits superior cannabinoid dispersion properties and is not susceptible to oxidative degradation of a cannabinoid.SOLUTION: An oil-in-detergent type emulsion composition according to the present invention is obtained by emulsifying an oil phase in a detergent phase, wherein the oil phase contains a cannabinoid and the detergent phase contains an alcohol compound and a surfactant. The oil phase preferably contains an edible oil or fat, and the surfactant contains preferably a sucrose fatty acid ester. This oil-in-detergent emulsion composition according to the present invention is capable of improving cannabinoid dispersion properties and is not susceptible to oxidative degradation of the cannabinoid.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an O / D type emulsion composition. [Background technology]

[0002] Cannabinoids are contained in the leaves and seed coats of hemp plants and are known to contain various components, including cannabidiol (CBD).Cannabidiol has unique effects and is widely used in the food industry, such as as a food additive, and in the medical industry, such as in pharmaceutical preparations, making it a highly useful component.

[0003] For example, Patent Document 1 proposes a solubilized product of a combination of curcumin and at least one cannabinoid, which makes it possible to obtain a clear mixture when mixed with water. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 6-145598 Summary of the Invention [Problem to be solved by the invention]

[0005] However, cannabinoids, particularly cannabidiol, have poor dispersibility in aqueous solvents such as water, and even when aqueous dispersions of cannabidiol are prepared using conventional methods, there is a problem that precipitates and separation occur over time. Furthermore, there has been a demand for cannabidiol-containing compositions that are less likely to lose dispersibility in aqueous solvents even after storage at high temperatures, i.e., have excellent storage stability.

[0006] The present invention has been made in view of the above, and aims to provide a cannabinoid-containing composition that can disperse cannabinoids well in an aqueous dispersion medium and has excellent storage stability. [Means for solving the problem]

[0007] The present inventors have conducted extensive research to achieve the above object and have completed the present invention.

[0008] That is, the present invention includes, for example, the subject matter described in the following sections. <1> An O / D type emulsion composition in which an oil phase is emulsified in a D phase, the O / D type emulsion composition containing one or more selected from the group consisting of gelatin, hydroxyalkyl cellulose, and starch, the oil phase containing a cannabinoid, and the D phase containing an alcohol compound and a surfactant. <2> Further, the composition contains one or more selected from the group consisting of crystalline cellulose, lactose, silicates, corn starch, sodium lauryl sulfate, and magnesium stearate. <1> The O / D type emulsion composition according to claim 1. <3> Further, it contains one or more selected from the group consisting of glycerin and sorbitol. <1> or <2> The O / D type emulsion composition according to claim 1. <4> The cannabinoid comprises cannabidiol. <1> ~ <3> The O / D type emulsion composition according to any one of the above. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide a cannabinoid-containing composition in which the cannabinoid is well dispersed and which has excellent storage stability. DETAILED DESCRIPTION OF THE INVENTION

[0010]

[0023] In the present specification, the terms "contain" and "comprise" include the concepts of "contain," "comprise," "consist essentially of," and "consist only of."

[0011] The O / D type emulsion composition of the present invention comprises an oil phase emulsified in a D phase, the oil phase containing a cannabinoid, and the D phase containing an alcohol compound and a surfactant. This O / D type emulsion composition improves the dispersibility of the cannabinoid and also makes the cannabinoid less susceptible to oxidative degradation.

[0012] An O / D type emulsion is obtained by an emulsification method (referred to as a D-phase emulsification method) that utilizes a surfactant phase, or so-called D-phase (detergent phase), and is an emulsion in which an O-phase (i.e., an oil phase) is dispersed as, for example, minute droplets in the D-phase. It is also known that a fine O / W type emulsion can be obtained by mixing this O / D type emulsion with an aqueous phase.

[0013] (oil phase) In the O / D type emulsion composition of the present invention, the oil phase contains at least a cannabinoid, which may be, for example, one or more of the various compounds contained in hemp-derived cannabinoids (specifically, cannabidiol (CBD), tetrahydrocannabinol, etc.).

[0014] In particular, the cannabinoid preferably contains cannabidiol. In this case, the dispersibility of the oil phase in the D phase is likely to be improved and oxidative deterioration is unlikely to occur, so the O / D type emulsion composition of the present invention is likely to be applied in the fields of food, cosmetics, feed, and medicine.

[0015] The cannabinoid preferably contains 50% by mass or more of cannabidiol, more preferably 80% by mass or more, even more preferably 90% by mass or more, and particularly preferably 95% by mass or more. The cannabinoid may be cannabidiol alone.

[0016] Cannabinoids can be produced, for example, by known methods. Alternatively, commercially available cannabinoids can be used in the compositions of the present invention. Similarly, cannabidiol can be produced, for example, by known methods. Alternatively, commercially available cannabidiol can be used in the compositions of the present invention.

[0017] The oil phase preferably contains an edible oil or fat. In this case, the oil phase has particularly excellent dispersibility in the D phase and is less susceptible to oxidative deterioration, making the O / D type emulsion composition of the present invention particularly applicable to the fields of food, cosmetics, feed, and medicine.

[0018] Examples of edible fats and oils include synthetic fats and oils such as medium-chain fatty acid triglycerides, typified by MCT oil, as well as vegetable fats and oils such as cottonseed oil, castor oil, soybean oil, rapeseed oil, corn oil, olive oil, palm oil, safflower oil, rice oil, sunflower oil, and sesame oil; and animal fats and oils such as lard, beef tallow, milk fat, and fish oil. Commercially available edible fats and oils can be used widely. The edible fats and oils contained in the oil phase can be one type alone or two or more types.

[0019] When the oil phase contains edible oils and fats, the content ratio thereof is not particularly limited. For example, the content of edible oils and fats is preferably 50 parts by mass or more, more preferably 60 parts by mass or more, and even more preferably 70 parts by mass or more, and is preferably 300 parts by mass or less, more preferably 200 parts by mass or less, even more preferably 150 parts by mass or less, and particularly preferably 120 parts by mass or less, relative to 100 parts by mass of the total mass of cannabinoids.

[0020] The oil phase may contain components other than cannabinoids and edible oils and fats, or may consist solely of cannabinoids and edible oils and fats, as long as the effects of the present invention are not impaired. Examples of components other than cannabinoids and edible oils and fats include a wide range of components contained in the oil phase of known O / D type emulsions, such as fatty acids, waxes, and fat-soluble vitamins.

[0021] (D phase) Phase D contains an alcohol compound and a surfactant, and in particular functions as a medium for dispersing the oil phase.

[0022] Examples of surfactants contained in phase D include a wide variety of emulsifiers used in phase D of known O / D emulsions. In the present invention, the molecular weight of the surfactant is 200 or more.

[0023] Examples of surfactants include sucrose fatty acid esters, as well as synthetic surfactants such as sorbitan fatty acid esters, polyglycerol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyglycerol condensed ricinoleate esters, and propylene glycol fatty acid esters; and non-synthetic surfactants such as phospholipids, glycolipids, enzyme-treated egg yolk, saponin, plant sterols, and milk fat globule membranes. Phase D may contain one type of surfactant alone or two or more types.

[0024] In particular, the surfactant contained in phase D preferably contains a sucrose fatty acid ester. In this case, phase D easily disperses the oil phase and also reduces the risk of oxidative degradation of cannabinoids, making the O / D type emulsion composition of the present invention more applicable to the food, cosmetic, feed, or pharmaceutical fields. The surfactant contained in phase D may be solely a sucrose fatty acid ester.

[0025] The type of sucrose fatty acid ester is not particularly limited, and for example, a wide variety of known sucrose fatty acid esters can be used. As a precaution, in this specification, the term "sucrose fatty acid ester" refers to an ester compound of sucrose and a fatty acid.

[0026] In the present invention, the sucrose fatty acid ester preferably has an average degree of esterification of 1.0 to 1.15. In this case, the D phase is particularly easy to disperse the oil phase, and oxidative degradation of cannabinoids is particularly unlikely to occur, making the O / D type emulsion composition of the present invention suitable for use in the food, cosmetics, feed, or pharmaceutical fields.

[0027] The average degree of esterification of the sucrose fatty acid ester is preferably 1.01 or more, and is preferably 1.3 or less, more preferably 1.2 or less, and particularly preferably 1.15 or less.

[0028] In the present invention, the average degree of esterification of sucrose fatty acid esters can be calculated as the average degree of esterification X of sucrose fatty acid esters by the following formula (1). (Ns-X)=(Nx) / (Ny) ={(OHV) / (1000×56.11)} / {1 / (MwSug+(MwFa-18)X)} (1)

[0029] Here, the meanings of the symbols in formula (1) are as follows: Ns: number of OH groups in one sucrose molecule Nx: Number of moles of OH groups in 1 g of sample (sucrose fatty acid ester) Ny: number of moles of sucrose fatty acid ester in 1 g of sample OHV: hydroxyl value of sucrose fatty acid ester MwSug: molecular weight of sucrose MwFa: average molecular weight of constituent fatty acids

[0030] X can be calculated by substituting known values ​​of Ns, Nx, Ny, OHV, MwSug, and MwFa into the above formula (1). Note that Ns, Nx, Ny, OHV, MwSug, and MwFa can be measured by known methods.

[0031] As can be seen from the above method for calculating the average degree of esterification, a sucrose fatty acid ester can be said to be an aggregate of sucrose fatty acid ester molecules with different degrees of esterification.

[0032] When a commercially available product is used as the sucrose fatty acid ester in the composition of the present invention, the value disclosed by the manufacturer, such as the manufacturer's guaranteed value or catalog value of the sucrose fatty acid ester, can be used as the value of the average degree of esterification.

[0033] In the sucrose fatty acid ester, the type of the fatty acid moiety (RCOO-moiety) is not particularly limited. The fatty acid moiety of the sucrose fatty acid ester may be a moiety derived from a saturated fatty acid or an unsaturated fatty acid, and is preferably derived from a saturated fatty acid.

[0034] In sucrose fatty acid esters, the number of carbon atoms in the fatty acid moiety is not particularly limited, and from the viewpoint of easily increasing the dispersibility of cannabinoids, the number of carbon atoms in the fatty acid moiety (including ester carbons) is preferably 30 or less, more preferably 25 or less, even more preferably 20 or less, and particularly preferably 18 or less. Furthermore, from the viewpoint of easily increasing the dispersibility of cannabinoids, the number of carbon atoms in the fatty acid moiety (including ester carbons) is preferably 8 or more, more preferably 10 or more, even more preferably 12 or more, and particularly preferably 14 or more. The fatty acid moiety in sucrose fatty acid esters is preferably derived from, for example, lauric acid, palmitic acid, stearic acid, etc.

[0035] Sucrose fatty acid esters exist in monoester, diester, and triester forms. The sucrose fatty acid ester contained in the composition of the present invention may be any of these ester forms, or may contain not only one but also two or all of the ester forms. In other words, the sucrose fatty acid ester may contain one or more sucrose fatty acid esters selected from the group consisting of monoester, diester, and triester forms.

[0036] The method for producing sucrose fatty acid esters is not particularly limited, and any known production method can be widely used. For example, sucrose fatty acid esters can be synthesized by transesterification of sucrose and fatty acid esters. Examples of fatty acid esters include methyl esters of fatty acids.

[0037] The sucrose used in the method for producing sucrose fatty acid esters may be synthesized by a known method, or sucrose may be commercially available. The sucrose may be unreacted sucrose recovered during the production of sucrose fatty acid esters (so-called "recovered sugar"). The sucrose may be in the form of a solid or a solution dissolved in a solvent. The fatty acid used in the method for producing sucrose fatty acid esters may be synthesized by a known method, or sucrose may be commercially available.

[0038] The method for adjusting the average degree of esterification of the sucrose fatty acid ester is not particularly limited, and for example, a wide variety of known methods can be adopted. For example, by adjusting various synthesis conditions such as the ratio of sucrose and fatty acid or its ester used in the production of the sucrose fatty acid ester, the type of fatty acid, and the esterification reaction conditions, the average degree of esterification of the obtained sucrose fatty acid ester can be controlled within a desired range.

[0039] Alternatively, a sucrose fatty acid ester having a known average degree of esterification controlled within a desired range can be obtained by mixing two or more sucrose fatty acid esters having different average degrees of esterification. In this case, the average degree of esterification can be easily adjusted to a desired range based on the esterification degree of each sucrose fatty acid ester and the mixing mass ratio.

[0040] The content of the surfactant contained in phase D is not particularly limited. For example, in terms of easily increasing dispersibility and easily suppressing oxidative degradation, the content of the surfactant contained in the O / D type emulsion composition of the present invention is preferably 5 parts by mass or more, more preferably 6 parts by mass or more, and even more preferably 7 parts by mass or more, relative to 100 parts by mass of cannabinoid, and is preferably 50 parts by mass or less, more preferably 40 parts by mass or less, even more preferably 35 parts by mass or less, and particularly preferably 30 parts by mass or less.

[0041] The alcohol compound contained in the D phase can be a wide range of alcohol compounds contained in the D phase of known O / D emulsions. Examples of the alcohol compound include polyhydric alcohols and monoalcohols. In the present invention, the alcohol compound has a molecular weight of 40 or more and less than 200. The alcohol compound can, for example, act as a bridge between the oil phase and the D phase.

[0042] The alcohol compound contained in phase D preferably contains at least a polyhydric alcohol. In this case, phase D easily disperses the oil phase and also makes oxidative degradation of cannabinoids less likely to occur, making the O / D emulsion composition of the present invention more applicable to the food, cosmetic, feed, or pharmaceutical fields. The alcohol compound contained in phase D may be a mixture of a polyhydric alcohol and a monoalcohol, or the alcohol compound may be a polyhydric alcohol only.

[0043] The polyhydric alcohol is a compound having two or more hydroxyl groups in the molecule, such as glycerin and propylene glycol. Other examples include polyglycerins such as diglycerin, triglycerin, and tetraglycerin; and sugars such as glucose, maltose, maltitol, sucrose, fructose, xylitol, inositol, pentaerythritol, sorbitol, maltotriose, and starch decomposition sugars. Among these, the polyhydric alcohol is preferably one or more selected from the group consisting of glycerin, D-sorbitol, and propylene glycol, and more preferably contains glycerin, because of its excellent dispersibility in the oil phase and its ability to easily suppress the acid value degradation of cannabinoids. The polyhydric alcohol may be one type alone or two or more types.

[0044] The monoalcohol is a compound having one hydroxyl group in the molecule, and examples thereof include ethanol, isopropanol, etc., with ethanol being preferred. The monoalcohol may be one type alone or two or more types.

[0045] The content of the alcohol compound contained in phase D is not particularly limited. For example, in terms of easily increasing dispersibility, the content of the alcohol compound contained in the O / D type emulsion composition of the present invention is preferably 100 parts by mass or more, more preferably 125 parts by mass or more, and even more preferably 150 parts by mass or more, relative to 100 parts by mass of cannabinoid, and is preferably 1000 parts by mass or less, more preferably 800 parts by mass or less, even more preferably 600 parts by mass or less, and particularly preferably 500 parts by mass or less.

[0046] When the alcohol compound contained in phase D is a mixture of a polyhydric alcohol and a monoalcohol, the ratio of the two is not particularly limited. For example, the content of the monoalcohol relative to the total mass of the polyhydric alcohol and the monoalcohol is preferably 15 mass% or less, and more preferably 10 mass% or less.

[0047] In Phase D, the ratio of the alcohol compound to the surfactant is not particularly limited as long as the effects of the present invention are not impaired. For example, the surfactant is preferably contained in an amount of 0.5 to 20 parts by mass, more preferably 1 to 15 parts by mass, and even more preferably 2 to 10 parts by mass, per 100 parts by mass of the alcohol compound.

[0048] Phase D may contain components other than the alcohol compound and the surfactant, as long as the effects of the present invention are not impaired, or Phase D may consist only of the alcohol compound and the surfactant.

[0049] (O / D type emulsion composition) The O / D type emulsion composition of the present invention is formed from the oil phase and the D phase.

[0050] The content of cannabinoid in the OD type emulsion composition of the present invention is not particularly limited. For example, when the total mass of cannabinoid, edible oil / fat, surfactant, and alcohol compound is S, the content of cannabinoid is preferably 5% by mass or more, more preferably 10% by mass or more, and preferably 50% by mass or less, more preferably 40% by mass or less, and even more preferably 30% by mass or less, relative to the total mass S.

[0051] In the O / D emulsion composition of the present invention, when the oil phase contains an edible oil or fat, the content thereof is not particularly limited. For example, in the O / D emulsion composition of the present invention, the content of the edible oil or fat is preferably 5% by mass or more, more preferably 8% by mass or more, and even more preferably 10% by mass or more, relative to the total mass S, and is preferably 30% by mass or less, more preferably 25% by mass or less, and even more preferably 20% by mass or less.

[0052] The content of the surfactant in the O / D emulsion composition of the present invention is not particularly limited. For example, the content of the surfactant in the O / D emulsion composition of the present invention is preferably 0.5% by mass or more, more preferably 1% by mass or more, and is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less, relative to the total mass S.

[0053] The O / D type emulsion composition of the present invention may contain other components in addition to cannabinoids, edible oils and fats, surfactants, and alcohol compounds, as long as the effects of the present invention are not impaired. For example, other components include various components widely used in food applications and various components widely used in pharmaceutical applications. When the O / D type emulsion composition of the present invention contains such other components, the content thereof is, for example, 50% by mass or less, preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 10% by mass or less, and particularly preferably 1% by mass or less, relative to the total mass of the composition.

[0054] In the O / D type emulsion composition of the present invention, the average particle size of the oil droplets constituting the oil phase is not particularly limited, and for example, the median diameter (D50) of the oil droplets constituting the oil phase is preferably 2 μm or less, more preferably 1.8 μm or less, even more preferably 1.5 μm or less, particularly preferably 1 μm or less, and preferably 0.1 μm or more, more preferably 0.2 μm or more, and even more preferably 0.3 μm or more. The median diameter (D50) refers to the particle diameter D50 at which the cumulative frequency in the scattering intensity distribution is 50%.

[0055] The average particle size of the oil droplets in the O / D type emulsion composition of the present invention is a value measured by a laser diffraction scattering method using a particle size measuring device (product name: SALD-2300, manufactured by Shimadzu Corporation), and particularly means a value measured in accordance with the method described in the examples.

[0056] The O / D type emulsion composition of the present invention can be used in a variety of applications, particularly in applications where compositions containing cannabidiol have traditionally been used. Specifically, the composition of the present invention can be used for food, cosmetics, feed, pharmaceuticals, etc. As used herein, "food use" broadly encompasses beverages, supplements, health foods, functional foods, beauty foods, and animal feed for pets and other animals. Furthermore, as used herein, "feed use" broadly encompasses feeds that can be used in various livestock farming fields, including feeds used in aquaculture. As used herein, "medicinal use" includes pharmaceuticals intended for administration to humans as well as pharmaceuticals intended for administration to animals. When the composition of the present invention is used for food, cosmetics, or pharmaceuticals, all of these applications include those intended for cosmetic purposes.

[0057] As described above, the O / D type emulsion composition of the present invention can be particularly suitably used as, for example, a food additive, a feed additive, a pharmaceutical additive, and a cosmetic additive.

[0058] An O / W emulsion can be obtained by using the O / D emulsion composition of the present invention. The method for obtaining an O / W emulsion is not particularly limited, and for example, an O / W emulsion can be obtained by mixing an aqueous solvent such as water with the O / D emulsion composition of the present invention. Such an O / W emulsion can also be used in the various applications and with various additives described above.

[0059] The method for producing the O / D emulsion composition of the present invention is not particularly limited, and for example, the same production methods as those for known O / D emulsion compositions can be widely adopted. For example, the O / D emulsion composition of the present invention can be obtained by adding an oil phase containing a cannabinoid to a D phase prepared using an alcohol compound containing a surfactant and emulsifying the D phase (so-called D phase emulsification).

[0060] In the D phase emulsification, it is preferable to add the oil phase containing the cannabinoid dropwise to the D phase. In this case, for example, it is preferable to add the oil phase dropwise at a rate of 1 to 50 parts by mass / minute, and more preferably 5 to 25 parts by mass / minute, per 100 parts by mass of the total mass of the D phase.

[0061] In the D phase emulsification, the temperature of the D phase is not particularly limited and can be appropriately set taking into consideration the boiling point of the alcohol compound contained in the D phase, etc. For example, in the D phase emulsification, the temperature of the D phase can be 20 to 150°C, preferably 30 to 100°C. Furthermore, the method of adding an oil phase to the emulsified D phase and emulsifying it is not particularly limited, and a wide range of known emulsification means can be used in the present invention.

[0062] (additives) The O / D type emulsion composition of the present invention contains one or more selected from the group consisting of gelatin, hydroxyalkyl cellulose, and starch. The hydroxyalkyl cellulose is not particularly limited, but hydroxypropyl cellulose is preferred.

[0063] The O / D type emulsion composition of the present invention may contain one or more selected from the group consisting of crystalline cellulose, lactose, silicates, corn starch, sodium lauryl sulfate, and magnesium stearate.

[0064] The O / D type emulsion composition of the present invention may also contain one selected from the group consisting of glycerin and sorbitol.

[0065] The O / D type emulsion composition of the present invention may also contain one or more selected from the group consisting of glycerin fatty acid esters, beeswax, and vegetable oils. The vegetable oil is not particularly limited, but olive oil is preferred.

[0066] The O / D type emulsion composition of the present invention may be contained in a capsule when distributed on the market, for example. Examples of capsules include hard capsules and soft capsules.

[0067] Hard capsules are made, for example, by adding crystalline cellulose, lactose, silicates, corn starch, sodium lauryl sulfate, magnesium stearate, etc. to a base material made of gelatin and hydroxypropylcellulose.

[0068] Soft capsules are made, for example, from a base material consisting of gelatin and starch to which glycerin and sorbitol are added for the purpose of adjusting the coating, and the filling liquid is made from glycerin fatty acid esters, beeswax, olive oil, etc. [Example]

[0069] The present invention will be explained in more detail below with reference to examples, but the present invention is not limited to these examples.

[0070] (Raw materials used) Appropriate raw materials were selected from the following raw materials to prepare an O / D type emulsion composition in which an oil phase was emulsified in a D phase.

[0071] <Cannabinoids> Cannabidiol (CBD), manufactured by Sigma-Aldrich

[0072] <Edible fats and oils> MCT oil; product name: Actor M-1, manufactured by Riken Vitamin Co., Ltd.

[0073] <Surfactant> Sucrose fatty acid ester A (esterification degree 1.01): Obtained according to Production Example 1 described below.

[0074] <Alcohol compounds> Glycerin

[0075] <Additives> ·gelatin Starch Hydroxypropyl cellulose Crystalline cellulose ·lactose ·Silicates Cornstarch Sodium lauryl sulfate Magnesium stearate Sorbitol Glycerin fatty acid ester Beeswax ·olive oil

[0076] (Production Example 1) In a 1 L flask equipped with a stirrer, thermometer, pressure reducer, and dimethyl sulfoxide (DMSO) reflux device, 400 g of DMSO and 34.2 g of sucrose were mixed and dissolved at 95°C. 2.4 g of potassium carbonate and 15.0 g of methyl stearate (as a fatty acid ester) were added, and the mixture was allowed to react for 3 hours at 95°C under a reduced pressure of 2 kPa. Subsequently, lactic acid was added for neutralization, and the DMSO was removed by distillation under reduced pressure. The resulting crude product was dissolved in 200 g of methyl ethyl ketone, washed three times with 200 g of 10% saturated saline, and the solvent was removed by distillation under reduced pressure to obtain sucrose fatty acid ester A. The average degree of esterification of sucrose fatty acid ester A was 1.01.

[0077] Example 1 An O / D type emulsion composition was prepared according to the formulation shown in Table 1. Specifically, 10 g of cannabidiol and 10 g of MCT oil were mixed at 70°C to obtain an oil phase. Next, 2 g of sucrose fatty acid ester A and 44 g of glycerin were mixed in a separate container at 70°C to obtain a D phase. This D phase was maintained at 70°C, and the oil phase was added dropwise thereto over 5 minutes. The mixture was then emulsified (D phase emulsification) in a homogenizer at a rotation speed of 7000 rpm for 3 minutes to obtain an O / D type emulsion. Each additive in the amount shown in Table 1 was added thereto, and the mixture was further stirred in a homogenizer at a rotation speed of 7000 rpm for 3 minutes to obtain the O / D type emulsion composition of Example 1.

[0078] Examples 2 to 20 An O / D type emulsion composition was obtained in the same manner as in Example 1, except that the types and amounts of raw materials used were changed as shown in Table 1.

[0079] [Table 1]

[0080] (Evaluation method) The compositions obtained in the examples and comparative examples were evaluated according to the following procedures.

[0081] <Dispersibility> The composition obtained in each Example and Comparative Example immediately after production was diluted 100 times with water to prepare a dispersion with a concentration of 1% by mass, and 15 g of the dispersion was sealed and stored in a 20 mL container and allowed to stand at 25° C. After a predetermined period of storage, the appearance of the dispersion was observed, and the dispersibility was evaluated according to the following criteria. A: No precipitation or separation occurred within 1 hour after production. B: Precipitation or separation occurred immediately after production.

[0082] Table 1 shows the compounding conditions (all units are grams) for the compositions of each example and comparative example, as well as the evaluation results. Note that blank spaces in Table 1 indicate that the raw material was not used.

[0083] The results in Table 1 show that the O / D type emulsion compositions obtained in the examples have excellent dispersibility of cannabinoids.

Claims

1. An O / D type emulsion composition in which an oil phase is emulsified in a D phase, Contains one or more selected from the group consisting of gelatin, hydroxyalkyl cellulose, and starch; the oil phase contains a cannabinoid; The D phase contains an alcohol compound and a surfactant. O / D type emulsion composition.

2. The O / D type emulsion composition according to claim 1, further comprising one or more selected from the group consisting of crystalline cellulose, lactose, silicates, corn starch, sodium lauryl sulfate, and magnesium stearate.

3. The O / D type emulsion composition according to claim 1 or 2, further comprising one or more selected from the group consisting of glycerin and sorbitol.

4. The O / D type emulsion composition according to any one of claims 1 to 3, wherein the cannabinoid comprises cannabidiol.

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