Microneedle particles and method for producing the same

Abstract

The present invention relates to microneedle particles and methods for producing microneedle particles.

Description

[Technical field]

[0001] The present invention relates to microneedle particles and methods for producing microneedle particles. [Background technology]

[0002] Drugs and biologically active substances are commonly administered orally in the form of tablets or capsules, however, many drugs cannot be effectively delivered by these methods alone due to digestion or absorption in the gastrointestinal tract, or elimination by hepatic mechanisms. In addition, some drugs cannot effectively diffuse across the intestinal mucosa. Patient compliance is also an issue.

[0003] Another common technique for delivering drugs and bioactive substances is through the use of a traditional needle, which, although more effective than oral administration, can be problematic in that it can cause pain at the injection site, localized damage to the skin, bleeding and infection at the injection site.

[0004] To solve the problems of oral administration and subcutaneous injection, transdermal administration using a patch is used. Transdermal administration using a patch has few side effects, high patient compliance, and makes it easy to maintain a constant blood concentration of the drug.

[0005] For the above-mentioned transdermal administration, various microstructures including microneedles have been developed. Metals and various polymeric substances have been used as materials for microneedles. Recently, biodegradable polymeric substances have been in the spotlight as materials for microneedles.

[0006] Such microneedles are manufactured in the form of a patch provided with an adhesive sheet, and are attached to a desired site on the human body using the adhesive sheet.

[0007] However, because such microneedle products are manufactured in the form of patches, they can only be used in limited areas of the human body. Furthermore, there is a problem that if the adhesive strength of the adhesive sheet is weak, the effectiveness is very poor. Summary of the Invention [Problem to be solved by the invention]

[0008] The present invention has been made to solve the above problems, and aims to provide microneedle particles that can be used on a wide area of ​​the human body and can be used regardless of adhesive strength when used together with cosmetics, etc. [Means for solving the problem]

[0009] The above-mentioned objects of the present invention are achieved by a method for manufacturing microneedle particles, comprising the steps of providing a particle aggregate having a plurality of microneedle particles formed on an upper surface of a first film, and separating the microneedle particles from the particle aggregate, wherein the step of separating the microneedle particles from the particle aggregate comprises a step of weakening the adhesive force between the first film and the microneedle particles.

[0010] Here, the first film may be made of a water-soluble film. In addition, the first film may be made of any one of polyvinylpyrrolidone, polyvinyl alcohol, cellulose polymer, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, povidone, carbomer, ghatti gum, guar gum, glucomannan, glucosamine, dammer gum, rennet casein, locust bean gum, microfibrillated cellulose, psyllium seed gum, xanthan gum, arabinogalactan, gum arabic, alginic acid, gelatin, gellan gum, carrageenan, karaya gum, curdlan, chitosan, chitin, tara gum, tamarind gum, and the like. gum, tragacanth gum, furcelleran, pectin or pullulan, hydroxypropyl methylcellulose (HPMC), hydroxyalkylcellulose, ethyl hydroxyethylcellulose, alkylcellulose, gluten, soy polysaccharides, polacrilin potassium, sodium starch glycolate, crosspovidone, croscarmellose sodium, bentonite, hydroxypropyl starch, sodium carboxymethyl cellulose, sodium alginate, sodium lauryl sulfateThe biocompatible polymer may be one or a mixture of two or more selected from the group consisting of lauryl sulfate, silicic anhydride, hydroxypropyl cellulose, polyvinyl acetate, amylose, sodium hydrogen carbonate, amylopectin, sodium polyphosphate, and aluminum magnesium silicate.

[0011] Furthermore, the particle assembly may further include a second film attached to a lower surface of the first film.

[0012] The second film may be made of a hydrophobic film or a hydrophilic film. For example, the second film may be made of one or a mixture of two or more selected from the group consisting of high density polyethylene (HDPE), polystyrene (PS), polypropylene (PP), polyethylene terephthalate (PET), and polyethylene naphthalate (PEN).

[0013] Furthermore, the adhesive strength between the first film and the microneedle particles may be higher than the adhesive strength between the second film and the microneedle particles.

[0014] On the other hand, the step of weakening the adhesive force between the first film and the microneedle particles may include a step of treating the particle assembly with a solvent to dissolve the first film or to swell the first film.

[0015] In this case, the solvent does not have to dissolve the microneedle particles.

[0016] For example, the solvent may be one or more substances selected from the group consisting of distilled water, ethanol, acetone, oleyl alcohol, isoparaffin, and dipropylene glycol.

[0017] On the other hand, when the first film is swelled with the solvent, the method may further include a step of separating the microneedle particles from the first film by applying a lateral force to the microneedle particles.

[0018] In addition, when the first film is dissolved in the solvent, the method may further include a step of filtering the microneedle particles from the solvent and extracting the microneedle particles, and a step of drying the microneedle particles.

[0019] On the other hand, when treating the particle aggregate with the solvent, the particle aggregate may be treated using the solvent in a liquid state, or the solvent may be vaporized and the particle aggregate may be treated with the solvent in a gaseous state.

[0020] Furthermore, the above object of the present invention may be achieved by a microneedle particle manufactured by the above-mentioned method for manufacturing a microneedle particle. Effect of the Invention

[0021] According to the present invention having the above-mentioned configuration, when the microneedle particles are used together with cosmetics or the like, they can be used over a wide area of ​​the human body, and further can be used regardless of adhesive strength. [Brief description of the drawings]

[0022] [Figure 1]1 is a flow chart illustrating a method for manufacturing microneedle particles according to one embodiment of the present invention. [Diagram 2] FIG. 2 illustrates a particle assembly according to one embodiment of the present invention. [Diagram 3] 1 is a conceptual diagram illustrating a process of treating a particle assembly with a liquid solvent according to an embodiment. [Figure 4] FIG. 13 shows a process in which the first film swells and separates the microneedle particles from the particle aggregate after solvent treatment. [Diagram 5] FIG. 13 is a diagram showing the state after solvent treatment in which the first film has been dissolved from the particle aggregate and the microneedle particles have been separated. [Figure 6] FIG. 13 shows a particle assembly according to another embodiment of the present invention. [Figure 7] 11A to 11C are diagrams illustrating a process for producing a particle assembly according to another embodiment. [Figure 8] 11 is a conceptual diagram showing a process of treating a particle assembly with a liquid solvent according to another embodiment. FIG. [Figure 9] FIG. 11 is a diagram showing a process in which the first film swells from the particle assembly to separate the microneedle particles after the particle assembly is treated with a solvent according to another embodiment. [Figure 10] FIG. 13 is a diagram showing a state in which the first film is dissolved from the particle assembly and the microneedle particles are separated from the particle assembly after the particle assembly is treated with a solvent according to another embodiment. [Figure 11] FIG. 1 is a schematic diagram showing an apparatus for vaporizing a solvent and supplying it to a particle aggregate for processing. [Figure 12] FIG. 2 is a conceptual diagram showing the process of using a cosmetic product containing microneedle particles according to the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0023] Hereinafter, a method for producing a microneedle particle according to an embodiment of the present invention will be described in detail with reference to the drawings.

[0024] FIG. 1 is a flow chart showing a method for producing a microneedle particle according to one embodiment of the present invention, and FIG. 2 is a diagram showing a particle assembly 100 according to one embodiment of the present invention.

[0025] Referring to Figures 1 and 2, the method for manufacturing the microneedle particles may include a step (S110) of providing a particle aggregate 100 having a plurality of microneedle particles 14 formed on an upper surface of a first film 12, and a step (S130) of separating the microneedle particles 14 from the particle aggregate 100.

[0026] Here, the particle aggregate 100 can be defined as a structure in which the microneedle particles 14 to be manufactured in the present invention are attached onto the film support layer 20 including the first film 12 .

[0027] For example, the particle assembly 100 may include a film support layer 20 including a first film 12 made of a water-soluble film, and a plurality of biodegradable microneedle particles 14 formed on the film support layer 20.

[0028] The first film 12 is preferably made of a material that dissolves or swells in a predetermined solvent when the microneedle particles 14 are separated from the particle aggregate 100, as described below.

[0029] The first film 12 may be made of any one of polyvinylpyrrolidone, polyvinyl alcohol, cellulose polymer, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, povidone, carbomer, ghatti gum, guar gum, glucomannan, glucosamine, dammer gum, rennet casein, locust bean gum, microfibrillated cellulose, psyllium seed gum, xanthan gum, arabinogalactan, gum arabic, alginic acid, gelatin, gellan gum, carrageenan, karaya gum, curdlan, chitosan, chitin, tara gum, tamarind gum, and the like. gum, tragacanth gum, furcelleran, pectin or pullulan, hydroxypropyl methylcellulose (HPMC), hydroxyalkylcellulose, ethyl hydroxyethylcellulose, alkylcellulose, gluten, soy polysaccharides, polacrilin potassium, sodium starch glycolate, crosspovidone, croscarmellose sodium, bentonite, hydroxypropyl starch, sodium carboxymethyl cellulose, sodium alginate, sodium lauryl sulfate, silicic acidThe biocompatible polymer may be one or a mixture of two or more selected from the group consisting of polyvinyl acetate, amylose, sodium hydrogen carbonate, amylopectin, sodium polyphosphate, and aluminum magnesium silicate.

[0030] On the other hand, the microneedle particle 14 may have a shape in which the diameter or area of ​​the lower part is larger than the diameter or area of ​​the upper part. That is, the microneedle particle 14 may have a cone-like or pyramidal shape with a pointed upper part, or may have a shape with a pointed end at the upper part. In this way, if the microneedle particle 14 has a shape with a pointed end at the upper part, it can be more effectively penetrated into the skin of the human body when it is used by being blended with cosmetics, etc., as described later.

[0031] For example, the microneedle particles 14 may be made of a biocompatible and biodegradable material that dissolves upon insertion into the skin.

[0032] Examples include hyaluronic acid and its salts, polyvinylpyrrolidone, polyvinyl alcohol, cellulose polymer, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, povidone, carbomer, ghatti gum, guar gum, glucomannan, glucosamine, dammer resin, rennet casein, locust bean gum, microfibrillated cellulose, psyllium seed gum, xanthan gum, arabinogalactan, gum arabic, alginic acid, gelatin, gellan gum, carrageenan, karaya gum, curdlan, chitosan, chitin, tara gum, tamarind gum, etc. gum, tragacanth gum, furcelleran, pectin or pullulan, hydroxypropyl methylcellulose, hydroxyalkyl cellulose and carboxymethyl cellulose may also be used.

[0033] The particle aggregate 100 can be manufactured by various known methods, including a mold method, and therefore the method for manufacturing the particle aggregate 100 is not particularly limited.

[0034] Fig. 3 is a conceptual diagram showing a process of treating the particle aggregate 100 with a solvent 32. For example, Fig. 3 shows a process of treating the particle aggregate 100 with a solvent 32 in a liquid state.

[0035] 2 and 3, the step of separating the microneedle particles 14 may include a step of weakening the adhesive force between the first film 12 and the microneedle particles 14.

[0036] For example, the step of weakening the adhesive force between the first film 12 and the microneedle particles 14 may include the step of dissolving the first film 12 or swelling the first film 12.

[0037] First, a method for swelling the first film 12 will be described.

[0038] In this embodiment, the particle aggregate 100 is treated with a predetermined solvent 32, and the first film 12 of the particle aggregate 100 is swelled by the solvent 32, thereby weakening the adhesive force between the first film 12 and the microneedle particles 14.

[0039] In this case, the solvent 32 may be selected as a substance that swells the first film 12 but does not dissolve the microneedle particles 14 .

[0040] For example, the solvent 32 may be one or more substances selected from the group consisting of distilled water, ethanol, acetone, oleyl alcohol, isoparaffin, and dipropylene glycol. The above-mentioned solvents have the property of swelling the first film 12 well while not dissolving the microneedle particles 14 made of the above-mentioned components or substances.

[0041] However, when the solvent 32 is composed of an aqueous ethanol solution, if the concentration of ethanol in the aqueous ethanol solution is less than about 70% (i.e., if the concentration of water is greater than about 30%), the microneedle particles 14 may dissolve in the solvent 32. Therefore, the concentration of ethanol in the aqueous ethanol solution is preferably 70% or more.

[0042] 3, the particle aggregate 100 can be supplied to a housing 30 or a tank or the like that contains a predetermined liquid-state solvent 32, and immersed in the liquid-state solvent 32. The particle aggregate 100 is immersed in the solvent 32 and treated by the solvent 32.

[0043] In this case, as described above, the first film 12 of the particle aggregate 100 can be swelled by the solvent 32 .

[0044] FIG. 4 is a diagram showing a process of separating the microneedle particles 14 from the particle aggregate 100 after the solvent treatment.

[0045] FIG. 4(A) shows the particle aggregate 100 before the solvent treatment, and FIG. 4(B) shows the particle aggregate 100 after the solvent treatment.

[0046] The particle aggregate 100 before the solvent treatment shown in Fig. 4(A) expands as the first film 12 swells, as shown in Fig. 4(B) after the solvent treatment. When the first film 12 swells, the surface area of ​​the first film 12 increases, and the adhesive force between the microneedle particles 14 and the first film 12 becomes weaker than before the first film 12 swells.

[0047] As described above, following the step of weakening the adhesive force between the first film 12 and the microneedle particles 14, the method may further include a step of separating the microneedle particles 14 from the first film 12 by applying a lateral force to the microneedle particles 14.

[0048] As shown in (C) of Figure 4, when a lateral force F is applied to the microneedle particle 14, the microneedle particle 14 is easily separated from the first film 12, and as shown in (D) of Figure 4, the microneedle particle 14 can be separated and extracted from the first film 12.

[0049] The lateral force F applied to the microneedle particle 14 can be applied manually by an operator or automatically by a mechanical device.

[0050] After the microneedle particles are extracted by the above-mentioned method, the extracted microneedle particles are dried.

[0051] Ultimately, the microneedle particles 14 produced by the above-mentioned method can be used by being incorporated into cosmetics including lotions, creams, and the like.

[0052] On the other hand, Figure 5 is a conceptual diagram showing the process of separating the microneedle particles 14 from the particle aggregate 100 by dissolving the first film 12 in the step of weakening the adhesive force between the first film 12 and the microneedle particles 14.

[0053] Referring to Figure 5, in the step of separating the microneedle particles, the microneedle particles 14 are separated from the film support layer 20 by treating the particle aggregate 100 with a solvent 32 that dissolves the first film 12 but does not dissolve the microneedle particles 14.

[0054] That is, in this embodiment, the first film 12 is dissolved by a predetermined solvent 32, and the microneedle particles 14 are separated from the film support layer 20. In this case, the solvent 32 can be selected to be a substance that dissolves only the first film 12 and does not dissolve the microneedle particles 14.

[0055] In this case, the first film 12 of the particle assembly 100 is dissolved by the solvent 32, and the microneedle particles 14 are left behind in the solvent 32, as shown in FIG.

[0056] The microneedle particles 14 are then extracted from the solvent 32 by filtration, and the microneedle particles 14 are dried.

[0057] Meanwhile, FIG. 6 is a diagram showing a particle assembly 100' according to another embodiment of the present invention.

[0058] Referring to FIG. 6, in a particle assembly 100' according to this embodiment, a second film 10 may be further included in the above-mentioned film support layer 20'.

[0059] In this case, the second film 10 may be provided on the lower surface of the first film 12. That is, the first film 12 may be formed on the upper surface of the second film 10 by a method such as coating.

[0060] The second film 10 may function as a support sheet or film for the particle aggregates 100 .

[0061] The second film 10 may be made of a hydrophobic film, but is not limited thereto, and may be made of a hydrophilic film.

[0062] For example, the second film 10 may be made of one or a mixture of two or more selected from the group consisting of high density polyethylene (HDPE), polystyrene (PS), polypropylene (PP), polyethylene terephthalate (PET), and polyethylene naphthalate (PEN).

[0063] The first film 12 can be selected so that the adhesive strength between the first film 12 and the microneedle particles 14 is higher than the adhesive strength between the second film 10 and the microneedle particles 14. The adhesive strength between the first film 12 and the microneedle particles 14 will be described in detail in the step of manufacturing the microneedle particles 14.

[0064] FIG. 7 is a diagram showing steps for producing a particle assembly 100' according to another embodiment described above.

[0065] Referring to Figure 7, the step of providing the particle aggregate 100' may include first providing a pair of the second films 10, forming a pair of film support layers 20' by providing a first film 12 formed on each of the pair of second films 10 and enhancing adhesion with the microneedle particles 14, and spotting a biodegradable viscous substance 13 on at least one of the first films 12 of the pair of film support layers 20'.

[0066] The pair of second films 10 serve as a supporting film for the film supporting layer 20' of the particle aggregate 100'.

[0067] The second film 10 may be provided, for example, on a pair of substrates (not shown). In this case, the second film 10 may be provided by being applied and dried on the substrate, or may be provided in a sheet state.

[0068] Meanwhile, a first film 12 is provided on each of the pair of second films 10. The first film 12 can be coated on the second film 10, thereby forming a film layer.

[0069] If the first film 12 is omitted, the viscous material 13 forming the microneedle particles 14 is spotted directly on the second film 10. In this case, the adhesive strength between the viscous material 13 and the second film 10 is weak, so that the viscous material 13 cannot form a pointed end in the stretching step described below. That is, since the viscous material 13 may be separated from the second film 10 in the stretching step, the film support layer 20' cannot be sufficiently separated, and the upper and lower viscous materials 13 form microneedle particles in a state of being attached to each other. Such microneedle particles have a so-called hourglass shape, and the penetration effect into the skin is reduced.

[0070] Therefore, in this embodiment, the first film 12 is provided on the second film 10. In this case, the first film 12 can be selected so that the adhesive strength between the first film 12 and the microneedle particles 14 is higher than the adhesive strength between the second film 10 and the microneedle particles 14.

[0071] In addition, the adhesive strength between the first film 12 and the microneedle particles 14 can be determined to be such that the viscous material 13 can form a pointed end, or greater, when the viscous material 13 is pulled by separating a pair of film support layers 20' from each other in the pulling step described below.

[0072] 7A illustrates, but is not limited to, spotting the viscous substance 13 on all of the first films 12 of the pair of film support layers 20'. For example, it is also possible to spot the viscous substance 13 on only one of the first films 12 of the pair of film support layers 20'.

[0073] Next, the pair of film support layers 20' are moved relatively closer to each other (Figure 7(A)), the viscous substance 13 and the first film 12 are brought into contact with each other between the first films 12 of the pair of film support layers 20', and the pair of film support layers 20' are separated to pull the viscous substance 13 (Figure 7(B)).

[0074] In this case, as described above, the adhesive strength between the viscous material 13 and the first film 12 can be determined to be such that the viscous material 13 can form a pointed end or more.

[0075] Then, the viscous material 13 is solidified, and the pair of film support layers 20' are separated to form microneedle particles 14 on each of the first films 12 of the pair of film support layers 20'.

[0076] In this case, the viscous material 13 may be solidified by a method such as blowing air. After the viscous material 13 has solidified sufficiently, the film support layer 20' is further separated, and the viscous material 13 that was connected to each other is separated, and microneedle particles 14 having pointed ends are formed (FIG. 7C).

[0077] Thereafter, as shown in FIG. 8, the particle aggregate 100' is treated with a liquid solvent 32, and then, as shown in FIG. 9, the microneedle particles 14 are separated from the particle aggregate 100'.

[0078] After the solvent treatment, the first film 12 of the particle aggregate 100' shown in Fig. 9(A) swells and expands as shown in Fig. 9(B) . When the first film 12 swells, the surface area of ​​the first film 12 increases, and the adhesive force between the microneedle particles 14 and the first film 12 becomes weaker than before the first film 12 swells.

[0079] Next, when a lateral force F is applied to the microneedle particle 14 as shown in (C) of Figure 9, the microneedle particle 14 is easily separated from the first film 12, and the microneedle particle 14 can be separated and extracted from the first film 12 as shown in (D) of Figure 9.

[0080] The lateral force F applied to the microneedle particle 14 can be applied manually by an operator or automatically by a mechanical device.

[0081] After the microneedle particles are extracted by the above-mentioned method, the extracted microneedle particles are dried.

[0082] Meanwhile, FIG. 10 is a conceptual diagram showing a process of dissolving the first film 12 in a particle aggregate 100' according to another embodiment, and separating the microneedle particles 14 from the particle aggregate 100'.

[0083] That is, the particle aggregate 100' is treated with a solvent 32 that dissolves the first film 12 but does not dissolve the microneedle particles 14. Therefore, it is possible to separate the microneedle particles 14 from the film support layer 20.

[0084] In this case, the first film 12 of the particle assembly 100' is dissolved by the solvent 32, and the microneedle particles 14 and the second film 10 are separated and remain in the solvent 32, as shown in FIG.

[0085] Meanwhile, after the microneedle particles 14 and the second film 10 are separated, the second film 10 is removed from the solvent 32, and the microneedle particles 14 are extracted by filtering. Since the second film 10 remains in the solvent 32, it can be easily taken out and removed.

[0086] Meanwhile, since the microneedle particles 14 remain in the solvent 32, the solvent 32 is filtered to extract the microneedle particles 14. Then, the microneedle particles are dried.

[0087] Meanwhile, Fig. 11 is a schematic diagram showing an apparatus for treating a particle assembly by vaporizing and supplying a solvent to the particle assembly. Fig. 11(A) shows an apparatus for treating a particle assembly 100 with a gaseous solvent according to one embodiment, and Fig. 11(B) shows an apparatus for treating a particle assembly 100' with a gaseous solvent according to another embodiment.

[0088] Referring to FIG. 11, in order to treat the particle aggregates 100, 100' with a vaporized solvent or a solvent in a gaseous state, a closed space capable of accommodating the particle aggregates 100, 100' is required.

[0089] 11, a chamber 1000 is used to provide a receiving space 1010 for receiving the particle aggregates 100, 100' inside the chamber 1000. Although the drawing shows a chamber 1000, it is not limited thereto and may be any sealed structure that can receive vaporized solvent and the particle aggregates 100, 100'.

[0090] Meanwhile, although not shown in the drawings, the chamber 1000 may have an opening (not shown) for inserting the particle aggregate 100, 100' into the storage space 1010, and a door (not shown) for opening and closing the opening.

[0091] A support plate 1100 on which the particle aggregates 100, 100' are placed may be provided in the receiving space 1010 inside the chamber 1000. The support plate 1100 may be realized as various structures on which the particle aggregates 100, 100' are placed or which can support the particle aggregates 100, 100'.

[0092] Meanwhile, a solvent supply unit 1200 may be installed at one side of the chamber 1000 to supply a vaporized solvent or a solvent in a gaseous state to the inside of the chamber 1000 .

[0093] For example, the solvent supply unit 1200 may vaporize ethanol and supply it to the inside of the chamber 1000. The supply amount and supply time of the vaporized solvent supplied by the solvent supply unit 1200 may be appropriately adjusted.

[0094] 11, when the particle aggregates 100, 100' are treated with a vaporized solvent, the first film 12 in the particle aggregates 100, 100' dissolves or swells, weakening the adhesive force between the first film 12 and the microneedle particles 140, allowing them to be separated. This has been described above, so a duplicated description will be omitted.

[0095] FIG. 12 is a conceptual diagram showing the process of using a cosmetic product containing microneedle particles 14.

[0096] As shown in FIG. 12(A), when a user applies the cosmetic to the skin and rubs it, the microneedle particles 14 contained in the cosmetic can penetrate the skin, as shown in FIG. 12(B).

[0097] In particular, the microneedle particles 14 according to the present embodiment have a pointed shape, and therefore have excellent skin penetration effects. The microneedle particles 14 are made of a biocompatible and biodegradable material, and therefore do not cause any harm to the human body even if they penetrate the skin.

[0098] In this way, when the microneedle particles 14 penetrate into the skin, the cosmetic ingredients can also penetrate together with or along with the microneedle particles 14, as shown in FIG. 12(C).

[0099] On the other hand, it is also possible to include a functional substance in the microneedle particle 14 itself. For example, in the step of producing the particle aggregate 100 described above, a functional substance can be included together with the viscous substance forming the microneedle particle 14.

[0100] Examples of such functional substances include wrinkle improving substances and moisture supplying substances, and the present invention is not limited to any particular substance.

[0101] Although the present invention has been described above with reference to preferred embodiments thereof, those skilled in the art will be able to implement the present invention in various modifications and alterations without departing from the spirit and scope of the present invention as set forth in the claims below. Therefore, it should be understood that any modified implementation that essentially includes the elements of the claims of the present invention is included in the technical scope of the present invention. [Explanation of symbols]

[0102] 10. Second Film 12 Film 1 14 Microneedle particles 20 Film support layer 32 Solvents 100 particle aggregates

Claims

1. providing a particle assembly having a plurality of microneedle particles formed on an upper surface of a first film; Separating the microneedle particles from the particle mass; Including, A method for manufacturing microneedle particles, characterized in that the step of separating the microneedle particles from the particle aggregate includes a step of weakening an adhesive force between the first film and the microneedle particles.

2. The method for producing microneedle particles according to claim 1 , wherein the first film is made of a water-soluble film.

3. The first film is Polyvinylpyrrolidone, polyvinyl alcohol, cellulose polymer, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, povidone, carbomer, ghatti gum, guar gum, glucomannan, glucosamine, dammar gum, rennet casein, locust bean gum, microfibrillated cellulose, psyllium seed gum, xanthan gum, arabinogalactan, gum arabic, alginic acid, gelatin, gellan gum gum), carrageenan, karaya gum, curdlan, chitosan, chitin, tara gum, tamarind gum, tragacanth gum, furcelleran, pectin or pullulan, hydroxypropyl methylcellulose (HPMC), hydroxyalkylcellulose, ethylhydroxyethylcellulose, alkylcellulose, gluten, soy polysaccharides, polacrilin potassium, sodium starch glycolate glycolate), crospovidone, croscarmellose sodium, bentonite, hydroxypropyl starch, sodium carboxymethyl cellulose, sodium alginate, sodium lauryl sulfate, silicic anhydrideThe method for producing microneedle particles according to claim 2, characterized in that the microneedle particles are made of one or a mixture of two or more selected from the group consisting of polyvinyl acetate, amylose, sodium hydrogen carbonate, amylopectin, sodium polyphosphate and aluminum magnesium silicate.

4. The method for producing microneedle particles according to claim 1 , wherein the particle assembly further comprises a second film attached to a lower surface of the first film.

5. The method for producing microneedle particles according to claim 4 , wherein the second film is made of a hydrophobic film or a hydrophilic film.

6. The second film is The method for producing microneedle particles according to claim 4, characterized in that the microneedle particles are made of one or a mixture of two or more selected from the group consisting of high density polyethylene (HDPE), polystyrene (PS), polypropylene (PP), polyethylene terephthalate (PET) and polyethylene naphthalate (PEN).

7. The method for producing a microneedle particle according to claim 4 , wherein an adhesive force between the first film and the microneedle particle is stronger than an adhesive force between the second film and the microneedle particle.

8. The step of weakening the adhesive force between the first film and the microneedle particles includes: The method for producing microneedle particles according to claim 1 or claim 4, further comprising a step of treating the particle assembly with a solvent to dissolve the first film or to swell the first film.

9. The method for producing microneedle particles according to claim 8 , wherein the solvent does not dissolve the microneedle particles.

10. The solvent is The method for producing microneedle particles according to claim 8, characterized in that the solvent is at least one selected from the group consisting of distilled water, ethanol, acetone, oleyl alcohol, isoparaffin, and dipropylene glycol.

11. When the first film is swelled with the solvent, The method of claim 8, further comprising the step of separating the microneedle particle from the first film by applying a lateral force to the microneedle particle.

12. When the first film is dissolved in the solvent, filtering and extracting the microneedle particles from the solvent; The method for producing microneedle particles according to claim 8, further comprising the step of drying the microneedle particles.

13. When treating the particle assembly with the solvent, The method for producing microneedle particles according to claim 8, characterized in that the particle aggregate is treated with the solvent in a liquid state, or the solvent is vaporized and the particle aggregate is treated with the solvent in a gaseous state.

14. A microneedle particle manufactured by the method for manufacturing a microneedle particle according to any one of claims 1 to 13.

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