Basket guide mechanism, basket, and basket-type sample low-temperature storage device
By designing a basket guidance mechanism for storing members and auxiliary guide members, the problem of unstable baskets in the existing technology in the low temperature environment is solved, and the stable positioning and operation of the refrigeration tubes are achieved during the transportation of liquid nitrogen cylinders.
Patent Information
- Application Number
- JP2024555456
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-05-16
- Filing Date
- 2023-04-21
- Publication Date
- 2025-04-16
Smart Images

Figure 2025511563000001_ABST
Abstract
Description
[Technical field]
[0001] The present invention relates to a basket guide mechanism, a basket, and a basket-type sample low-temperature storage device, and belongs to the technical field of biological sample storage. [Background technology]
[0002] Long-term storage of biological samples is usually achieved at the lowest possible temperature to inhibit biochemical reactions within the sample and improve the stability of various components within the sample; the lower the temperature, the longer the sample can be preserved.
[0003] Usually, the cryopreserved sample cells are placed in a cryopreservation tube, and the cryopreservation tube is placed in liquid nitrogen through a cryopreservation rack / box or directly in liquid nitrogen to achieve long-term stable storage of the sample. More specifically, the cryopreservation rack / box or the cryopreservation tube is usually placed in a liquid nitrogen cylinder through a basket to be frozen.
[0004] Currently, in a typical basket mechanism, a guide structure such as a multi-stage slide bar is provided on the side wall of the basket to increase stability when lifting the basket upwards, making it easier for the shovel board assembly on one side to remove the plate rack, but the guide structure such as the slide bar cannot withstand low temperatures, and when immersed in liquid nitrogen for a long period of time, deformation and condensation occur, and the expected stability effect cannot be obtained even when lifted. This is disadvantageous for operations such as the external shovel board assembly removing the plate rack, and when transporting the liquid nitrogen cylinder, the cryopreservation rack / cryopreservation box or cryopreservation tube stored in the basket is likely to slip sideways. Summary of the Invention [Problem to be solved by the invention]
[0005] The object of the present invention is to provide a basket guide mechanism, a basket, and a basket-type sample low-temperature storage device, which can solve the problem of poor stability when lifting the basket, which affects subsequent operations such as using a shovel, and can also solve the problem of freezing racks / freezing boxes or freezing tubes stored in the basket sliding sideways when transporting liquid nitrogen cylinders. [Means for solving the problem]
[0006] In order to solve the above technical problems, the present invention uses the following technical solutions. A basket guide mechanism, A storage member that is entirely disposed in a liquid nitrogen cylinder and has an upper end that is open and fitted to the outside of the basket, thereby restricting the cryopreservation tube storage member or the cryopreservation tube stored in the basket from coming out from the side; an auxiliary guide member is installed above the storage member and slidably connected thereto, and the auxiliary guide member is fitted outside the basket and contacts the basket via a guide structure to perform a relative sliding movement; The auxiliary guide member includes a drive member that moves vertically relative to the storage frame and basket under the control of the drive member.
[0007] Optionally, the storage member may include a storage frame which forms a shield on the sides of the basket to limit lateral sliding of the cryopreservation tube storage member or the cryopreservation tubes in the storage position of the basket. The storage frame is provided with a cooling port.
[0008] Optionally, a connection member may be provided on the exterior of the storage frame to attach the storage frame to a liquid nitrogen cylinder or to a rotating mechanism within the liquid nitrogen cylinder.
[0009] As an option, the auxiliary guide member includes an auxiliary guide frame, one end of which is slidably connected to the storage frame by a pair of slide rails and slide grooves, and the other end of which is fixedly connected to the driving member.
[0010] As an option, the driving member includes a driving motor, an output end of the driving motor is connected to the auxiliary guide frame by a slide block, and the slide block is mounted on a fixed rail.
[0011] As an option, the guide structure includes a guide wheel, which is installed inside the auxiliary guide frame and can slide in contact with the basket.
[0012] The above technical solution of the present invention has the following beneficial effects: The storage member is fitted to the outside of the basket, which provides a good guiding function and is not affected by deformation or condensation due to low temperature, and can effectively prevent the cryopreservation tube storage members or cryopreservation tubes stored in the basket from sliding sideways when transporting liquid nitrogen cylinders. The auxiliary guide member is designed and engaged with the storage member to further ensure the above-mentioned guiding effect and achieve a positioning function, which can accurately obtain and correct the position of the cryopreservation tube storage members or cryopreservation tubes in the basket, and contribute to smoothly lifting the basket and efficiently transferring and removing the cryopreservation tube storage members or cryopreservation tubes.
[0013] The present invention uses the following alternative technical solutions to solve the technical problems. A basket, The apparatus further includes a basket body for storing a cryopreservation tube storage member or cryopreservation tubes, and the basket body is further provided with the basket guide mechanism.
[0014] The above technical solution has the following beneficial effects: By installing a basket guide mechanism on the basket body, and further using the storage member and auxiliary guide member, an effective guiding effect on the basket can be realized, and the cryopreservation tube storage member or cryopreservation tube stored in the basket can be prevented from sliding sideways, and accurate position acquisition and correction of the cryopreservation tube storage member or cryopreservation tube inside the basket can be realized.
[0015] The present invention uses the following further technical solutions to solve the technical problems. A basket-type sample low-temperature storage device, The system includes a low temperature storage area and an operation area, a liquid nitrogen cylinder is provided in the low temperature storage area, and the basket is provided within the liquid nitrogen cylinder.
[0016] Optionally, a rotation mechanism may be further provided within the liquid nitrogen cylinder, the rotation mechanism being connected to the basket and capable of rotating the target basket to a position corresponding to a storage door of the liquid nitrogen cylinder.
[0017] As an option, the rotation mechanism includes a rotation motor, a rotation shaft, a support rotation base, and a base connected in upper and lower order, the rotation motor being installed outside the liquid nitrogen cylinder, the base being connected inside the liquid nitrogen cylinder, and the basket guide mechanism being connected to the support rotation base.
[0018] Optionally, a lifting mechanism is provided in the operating area, the lifting mechanism being located above the liquid nitrogen cylinder storage door and used to retrieve or load baskets.
[0019] As an option, the lifting mechanism includes a lifting motor, a slide rail, a vertical guide plate and a lifting platform, the lifting motor and the slide rail are fixedly connected to the vertical guide plate, the lifting platform is slidably connected to the slide rail and is driven by the lifting motor to perform lifting motion. The lift platform is provided with a hook portion for gripping the basket.
[0020] Optionally, the lift mechanism further includes a position sensor mounted on the slide rail and adapted to detect an operating position of the lift platform.
[0021] As an option, the drive member of the basket guide mechanism is mounted on a longitudinal guide plate of the lift mechanism.
[0022] As an option, a shovel cover mechanism is provided in the operating area, the shovel cover mechanism including a shovel cover motor, a lead screw nut assembly and a shovel cover shovel plate, the shovel cover shovel plate is horizontally fixed to the nut of the lead screw nut assembly, and the output end of the shovel cover motor is coaxially connected to the lead screw of the lead screw nut assembly.
[0023] As an option, a shovel plate mechanism is further provided in the operating area, the shovel plate mechanism including a shovel plate motor, a slide groove slide block assembly and a shovel plate, the shovel plate arranged laterally has one end fixedly connected to the slide block of the slide groove slide block assembly and the other end connected to the output end of the shovel plate motor.
[0024] This technical solution of the present invention has the following beneficial effects: In this basket-type sample low-temperature storage device, a basket having a basket guide mechanism is installed inside the liquid nitrogen cylinder, which ultimately enables more accurate correction of the position of the cryopreservation tube storage components or cryopreservation tubes, making it easier to perform subsequent operations such as removing them to the outside.Furthermore, it provides stable guidance for the basket to enter and exit the liquid nitrogen cylinder, and prevents the cryopreservation tube storage components or cryopreservation tubes stored in the basket from sliding sideways. [Brief description of the drawings]
[0025] [Figure 1]FIG. 1 is a perspective view of a basket-type sample low-temperature storage device according to the present invention. [Diagram 2] FIG. 2 is a schematic diagram of the internal structure of the basket-type low-temperature sample storage device according to the present invention. [Diagram 3] FIG. 3 is a perspective view of the basket guide mechanism+basket+lifting mechanism according to the present invention. [Figure 4] FIG. 4 is an enlarged view of a portion A in FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0026] The technical solutions of the present invention are further illustrated below by examples with reference to the drawings.
[0027] This embodiment provides a basket guide mechanism 113, which includes a storage member 1131 that is entirely disposed in the liquid nitrogen cylinder 11 and has an open upper end that is fitted outside the basket 111 to restrict the cryopreservation tube storage member or cryopreservation tube stored in the basket 111 from coming out from the side, an auxiliary guide member 1132 that is installed above the storage member 1131 and slidably connected thereto, and that is fitted outside the basket 111 and comes into contact with the basket 111 via a guide structure 1132-3 to perform relative sliding motion, and a driving member 1133 that causes the auxiliary guide member 1132 to move vertically relative to the storage frame 1131-1 and the basket 111 under the control of the driving member 1133. As a storage device for cryopreservation tubes, the cryopreservation tube storage member may be a cryopreservation rack or a cryopreservation plate such as a plate rack or an aluminum plate.
[0028] By disposing the auxiliary guide member 1132, in the process of the basket 111 moving upward, the auxiliary guide member 1132 moves upward along with the basket 111 while being driven by the driving member 1133, thereby more accurately correcting the position of the plate rack or the position of other cryopreservation tube storage members or cryopreservation tubes, and facilitating operations such as removing the plate rack to the outside. In this process, the basket 111 also moves upward relative to the storage member 1131 in the liquid nitrogen cylinder 11, and the storage member 1131 is used to guide the basket 111 in all directions, resulting in better operational stability, and the storage member 1131 simultaneously shields the inside of the basket 111 from the sides, solving the problem of the cryopreservation rack / cryopreservation box or cryopreservation tube stored in the basket 111 sliding sideways when the liquid nitrogen cylinder 11 is transported.
[0029] In a further embodiment of the invention, the storage member 1131 includes a storage frame 1131-1 which forms a shield on the side of the basket 111 to limit lateral sliding of the cryopreservation tube storage member or cryopreservation tubes in the basket storage position, and a cooling port is provided in the storage frame 1131-1.
[0030] The specific structure of the storage frame 1131-1 may be a frame that matches the outer shape of the illustrated basket 111, and by installing a shield structure on the side, it is sufficient to prevent the cryopreservation tube storage member or the cryopreservation tube from sliding sideways at the storage position of the basket, regardless of the specific type. At the same time, a cooling port needs to be installed in consideration of the cryopreservation effect.
[0031] In a further embodiment of the present invention, a connecting member 1131-2 may be further provided on the outside of the storage frame 1131-1, and the storage frame 1131-1 may be attached to the inside of the liquid nitrogen cylinder 11 or to a rotating mechanism inside the liquid nitrogen cylinder 11.
[0032] In a specific implementation, the connecting member 1131-2 may be fixed to one side of the outer wall of the storage frame 1131-1, and the structure of the connecting member 1131-2 may be a connecting plate extending along the length direction of the side wall of the storage frame 1131-1, with the upper end of the connecting plate being higher than the storage frame 1131-1 and provided with a hook. The hook mainly facilitates easy and flexible attachment and detachment, but the connecting plate can also improve the structural strength of the storage frame 1131-1 and help the storage frame 1131-1 guide and restrict the basket 111 from the side.
[0033] In a further embodiment of the present invention, the auxiliary guide member 1132 includes an auxiliary guide frame 1132-1, one end of which is slidably connected to the storage frame 1131-1 by a pair of slide rails and slide grooves 1132-2, and the other end of which is fixedly connected to the driving member 1133.
[0034] The pair of slide rail and slide groove 1132-2 includes a slide rail and a slide groove that are slidably engaged with each other. When specifically implemented, a slide rail may be installed on one side of the auxiliary guide frame 1132-1, and a slide groove may be installed in the storage frame 1131-1, or they may be installed interchangeably.
[0035] In a further embodiment of the present invention, the driving member 1133 includes a driving motor 1133-1, the output end of the driving motor 1133-1 is connected to the auxiliary guide frame 1132-1 by a sliding block 1133-2, and the sliding block 1133-2 is slidably mounted on a fixed rail 1133-3.
[0036] In concrete implementation, the slide block 1133-2 may be installed as a frame structure, which can improve the connection strength and reduce its own weight.
[0037] In a further embodiment of the present invention, the guide structure 1132-3 includes a guide wheel, which is installed inside the auxiliary guide frame 1132-1, and can contact and slide with the basket 111. Specifically, the guide wheel may be disposed above the auxiliary guide frame 1132-1, making the spatial layout more reasonable and less likely to cause interference.
[0038] This embodiment further provides a basket 111, which comprises a cryopreservation tube storage member or a basket body for storing cryopreservation tubes, and the basket body is further provided with the above-mentioned basket guiding mechanism 113.
[0039] Since the basket 111 is provided with the basket guide mechanism 113, all the problems in the process of taking the liquid nitrogen cylinder 11 in and out and the problem in the process of transporting the liquid nitrogen cylinder 11 are solved.
[0040] This embodiment further provides a basket-type sample low-temperature storage device, which includes a low-temperature storage area and an operation area 2, a liquid nitrogen cylinder 11 is provided in the low-temperature storage area, and the above-mentioned basket 111 is provided in the liquid nitrogen cylinder 11. The low-temperature storage area 1 and the operation area 2 may be separated by a reference plate, which is installed above the liquid nitrogen cylinder 11 through a housing, and the upper part of the reference plate may be the operation area 2, and the lower part of the reference plate is the low-temperature storage area. The liquid nitrogen cylinder 11 here may further be installed with a valve assembly 11-1 for intelligent control, which may be specifically attached to the housing.
[0041] In the low-temperature storage area 1, cooling and long-term storage of samples are mainly completed, and the operation area 2 is generally installed outside and above the low-temperature storage area 1, and is used to perform operations such as transfer, removal, and selection on the frozen storage tubes in the low-temperature storage area 1. The above-mentioned basket 111 is placed in the liquid nitrogen cylinder 11, i.e., the basket guide mechanism 113 having the storage member 1131 and the auxiliary guide member 1132, thereby allowing transportation and operation to be performed stably and efficiently.
[0042] In a further embodiment of the present invention, a rotation mechanism 112 is further provided in the liquid nitrogen cylinder 11, and the rotation mechanism 112 is connected to the basket 111, and can rotate the target basket 111 to a position corresponding to the storage door of the liquid nitrogen cylinder. The design of the rotation mechanism 112 further contributes to uniform cooling effect of multiple baskets 111 in the liquid nitrogen cylinder 11, and increases the cooling speed.
[0043] In a further embodiment of the present invention, the rotation mechanism 112 includes a rotation motor 1121, a rotation shaft 1122, a support rotation table 1123 and a base 1124 connected in order from top to bottom, the rotation motor 1121 being installed outside the liquid nitrogen bottle 11, the base 1124 being connected inside the liquid nitrogen bottle 11, and the basket guide mechanism 113 being connected to the support rotation table 1123.
[0044] In a further embodiment of the present invention, the operation area 2 is provided with a lifting mechanism 21, which is installed above the storage door of the liquid nitrogen cylinder 11 and is used to take out or take in the basket 111. After the lifting mechanism 21 engages with the basket 111, it can take out the basket 111 from the liquid nitrogen cylinder 11 by moving upward, and can take in the basket 111 into the liquid nitrogen cylinder 11 by moving downward.
[0045] In a further embodiment of the present invention, the lifting mechanism 21 includes a lifting motor 211, a slide rail 212, a vertical guide plate 213 and a lifting platform 214, the lifting motor 211 and the slide rail 212 are fixedly connected to the vertical guide plate 213, the lifting platform 214 is slidably connected to the slide rail 212 and is driven by the lifting motor 211 to perform lifting motion.
[0046] The lift platform 214 is provided with a hook portion 2141 for gripping the basket 111 .
[0047] In concrete implementation, the lift platform 214 can be designed as a right-angle bracket, with a hook part 2141 disposed below and conveniently connected to the vertical slide rail 212. The shape of the hook part 2141 can be designed to fit the suspended object 1111 on the basket 111, for example, when the suspended object 1111 is a pair of inverted L-shaped units installed facing each other, the hook part 2141 can be formed by connecting a vertical bar and a triangular plate, and the three ends of the triangular plate are used to simultaneously grab the two L-shaped units in multiple directions.
[0048] In a further embodiment of the present invention, the lifting mechanism 21 further includes a position sensor 215, which is installed on the slide rail 212 and is used to detect the operating position of the lift platform 214. Specifically, the position sensor 215 may be installed at the upper stroke end of the slide rail 212, and indicates that when the lift platform 214 slides to this point, it cannot continue to rise, or the basket 111 has risen to a predetermined position, for example, completely out of the storage frame 1131-1, and accordingly gives a corresponding prompt signal in relation to other operations.
[0049] In a further embodiment of the present invention, the driving member 1133 of the basket guide mechanism 113 is installed on the vertical guide plate 213 of the lifting mechanism 21. Since the basket 111 and the auxiliary guide member 1132 are in a nested relationship, their respective vertical motion structures are also correspondingly disposed in the center, which further contributes to the rationalization of the structural layout.
[0050] In a further embodiment of the present invention, a shovel cover mechanism 22 is provided in the operation area 2, and the shovel cover mechanism 22 includes a shovel cover motor 221, a lead screw nut assembly 222, and a shovel cover shovel plate 223, the shovel cover shovel plate 223 is horizontally fixed to the nut of the lead screw nut assembly 222, and the output end of the shovel cover motor 221 is coaxially connected to the lead screw of the lead screw nut assembly 222. The shovel cover mechanism 22 can open and close a cover body of a liquid nitrogen cylinder 11 or a temporary storage cylinder, etc.
[0051] In a further embodiment of the present invention, the operation area 2 is further provided with a shovel plate mechanism 23, which includes a shovel plate motor 231, a slide groove slide block assembly 232 and a shovel plate 233, and the shovel plate 233 arranged laterally has one end fixedly connected to the slide block of the slide groove slide block assembly 232 and the other end connected to the output end of the shovel plate motor 231. The shovel plate mechanism 23 can take out or put in a cryopreservation tube storage member, such as a cryopreservation rack or a cryopreservation box, from a basket.
[0052] Finally, the present invention has been described in detail with reference to the above embodiments, but it should be noted that the above embodiments are merely for illustrating the technical solutions of the present invention, and are not intended to limit the same. Those skilled in the art may modify the technical solutions described in the above embodiments, or equivalently replace some of the technical features therein, but it should be understood that such modifications or replacements do not deviate from the essence of the corresponding technical solutions and the spirit and scope of the technical solutions of the embodiments of the present invention. [Explanation of symbols]
[0053] 1 Cold storage area 11 Liquid nitrogen cylinder 11-1 Valve Assembly 111 Basket 1111 Suspended part 112 Rotation mechanism 1121 Rotary Motor 1122 Rotating shaft 1123 Support Rotating Table 1124 Pedestal 113 Basket guide mechanism 1131 Storage materials 1131-1 Storage Frame 1131-2 Connection parts 1132 Auxiliary guide member 1132-1 Auxiliary guide frame 1132-2 Pair of slide rail and slide groove 1132-3 Guidance structure 1133 Driving member 1133-1 Drive motor 1133-2 Slide block 1133-3 Fixed rail 2 Operation area 21 Lifting mechanism 211 Lifting motor 212 Slide rail 213 Vertical guide plate 214 Lift Exercise Platform 2141 Hook part 215 Position Sensor 22 Shovel cover mechanism 221 Shovel cover motor 222 Leadscrew Nut Assembly 223 Shovel cover Shovel plate 23 Shovel plate mechanism 231 Shovel Plate Motor 232 Slide groove slide block assembly 233 Shovel Plate
Claims
1. A basket guide mechanism comprising: A storage member that is entirely disposed in a liquid nitrogen cylinder and has an open upper end that is fitted to the outside of the basket, thereby restricting the cryopreservation tube storage member or the cryopreservation tube stored in the basket from coming out from the side; an auxiliary guide member is installed above the storage member and slidably connected thereto, and the auxiliary guide member is fitted outside the basket and contacts the basket via a guide structure to perform a relative sliding movement; A basket guide mechanism comprising: a driving member, the auxiliary guide member being controlled by a driving member to move vertically relative to the storage frame and basket.
2. The storage member includes a storage frame, and the storage frame forms a shield on a side of the basket, thereby limiting the sliding of the cryopreservation tube storage member or the cryopreservation tube in the storage position of the basket; 2. The basket guide mechanism according to claim 1, wherein the storage frame is provided with a cooling port.
3. 3. The basket guide mechanism according to claim 2, further comprising a connecting member provided on the outside of the storage frame, the connecting member being capable of attaching the storage frame to a liquid nitrogen cylinder or a rotating mechanism within the liquid nitrogen cylinder.
4. The basket guide mechanism according to claim 3, characterized in that the auxiliary guide member includes an auxiliary guide frame, one end of which is slidably connected to the storage frame by a pair of slide rails and slide grooves, and the other end of which is fixedly connected to the drive member.
5. 5. The basket guide mechanism according to claim 4, wherein the driving member includes a driving motor, the output end of the driving motor is connected to the auxiliary guide frame by a slide block, and the slide block is mounted on a fixed rail.
6. The basket guide mechanism according to claim 4 , wherein the guide structure includes a guide wheel, which is installed inside the auxiliary guide frame and can contact and slide with the basket.
7. A basket, A basket having a basket body for storing a cryopreservation tube storage member or a cryopreservation tube, A basket, further comprising the basket guide mechanism according to any one of claims 1 to 6 provided on the basket body.
8. A basket-type sample low-temperature storage device, A basket-type sample low-temperature storage device including a low-temperature storage area and an operation area, the low-temperature storage area being provided with a liquid nitrogen cylinder, 8. A basket-type sample low-temperature storage device, comprising: a basket according to claim 7 disposed in said liquid nitrogen cylinder.
9. The basket-type sample low temperature storage device of claim 8, further comprising a rotation mechanism connected to the basket and capable of rotating the target basket to a position corresponding to a storage door of the liquid nitrogen cylinder.
10. The basket-type sample low-temperature storage device of claim 9, wherein the rotation mechanism includes a rotation motor, a rotation shaft, a support rotation table, and a base connected in order from top to bottom, the rotation motor being installed outside the liquid nitrogen cylinder, the base being connected inside the liquid nitrogen cylinder, and the basket guide mechanism being connected to the support rotation table.
11. The basket-type sample low-temperature storage device according to claim 8, characterized in that a lifting mechanism is provided in the operation area, the lifting mechanism is installed above the storage door of the liquid nitrogen cylinder, and is used to take out or take in the basket.
12. The lifting mechanism includes a lifting motor, a slide rail, a vertical guide plate, and a lifting platform, the lifting motor and the slide rail are fixedly connected to the vertical guide plate, the lifting platform is slidably connected to the slide rail, and is driven by the lifting motor to perform lifting motion; 12. The basket-type sample low-temperature storage device according to claim 11, wherein the lift platform is provided with a hook for gripping the basket.
13. The basket-type sample low temperature storage device according to claim 12, wherein the lifting mechanism further comprises a position sensor, the position sensor being mounted on the slide rail and used to detect the operating position of the lift platform.
14. 14. The basket-type sample low-temperature storage device according to claim 11, 12 or 13, wherein the driving member of the basket guide mechanism is installed on a vertical guide plate of the lift mechanism.
15. The basket-type sample low temperature storage device according to claim 8, characterized in that a shovel cover mechanism is provided in the operation area, the shovel cover mechanism including a shovel cover motor, a lead screw nut assembly and a shovel cover shovel plate, the shovel cover shovel plate is horizontally fixed to the nut of the lead screw nut assembly, and the output end of the shovel cover motor is coaxially connected to the lead screw of the lead screw nut assembly.
16. The basket-type sample low-temperature storage device of claim 8, further comprising a shovel plate mechanism in the operation area, the shovel plate mechanism including a shovel plate motor, a slide groove slide block assembly and a shovel plate, the shovel plate arranged laterally has one end fixedly connected to the slide block of the slide groove slide block assembly and the other end connected to the output end of the shovel plate motor.
Citation Information
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