High pressure equipment for medical material processing

Abstract

The present application relates to the field of medical material production, and specifically discloses a high pressure equipment for medical material processing, which includes a pressure chamber for placing medical materials and / or raw materials for producing medical materials, and at least one through-hole is opened in the side wall of the pressure chamber, and the high pressure equipment further includes a sealing module for sealing the through-hole, and a fluid injection module is connected to the pressure chamber. A temperature adjustment module is installed in the pressure chamber. The present application can easily pressurize the pressure chamber, thereby realizing high pressure processing for the medical material. In addition, the temperature adjustment module of the present application can adjust the temperature of the fluid medium in the pressure chamber at any time when the temperature in the pressure chamber is too high or too low, thereby improving the effect of pressure processing for the medical material.

Description

[Technical field]

[0001] This application relates to the field of medical material manufacturing, and in particular to high pressure equipment for medical material processing. [Background technology]

[0002] Medical materials include biomedical materials, which are generally natural or synthetic special functional materials that are used to come into contact with and interact with living systems and can diagnose, treat, replace, repair or guide regeneration of cells, tissues and organs.

[0003] In the manufacturing or processing of medical materials, high pressure treatment is one of the operation methods. High pressure treatment performs sterilization in the manufacturing or processing of medical materials, while in the manufacturing process of some medical materials, such as decellularized tissue, high pressure can be further used to perform cell removal treatment on the raw material for manufacturing decellularized tissue, i.e., biological tissue.

[0004] Medical materials are one of the very important materials in the medical field, and the production and use of medical materials are widely paid attention to and valued, and high pressure treatment is an important operation method in the production or treatment process of medical materials. Therefore, in the production or treatment process of medical materials, it is very important to design high pressure equipment that can perform good high pressure treatment on medical materials or the raw materials for medical materials. Summary of the Invention [Problem to be solved by the invention]

[0005] In order to perform good high-pressure treatment on medical materials or raw materials for producing medical materials, the present application provides high-pressure equipment for treating medical materials. [Means for solving the problem]

[0006] The high pressure equipment for medical material processing provided in this application adopts the following technical solutions: A high-pressure device for treating medical materials, comprising a pressure chamber for placing medical materials and / or raw materials for manufacturing medical materials, at least one through groove is penetrated and opened on the side wall of the pressure chamber, the high-pressure device further includes a sealing module for sealing the through groove, and a fluid injection module is connected to the pressure chamber.

[0007] By adopting the above technical solution, after filling the pressure chamber with a fluid medium, the volume of the pressure chamber is kept as it is, and the fluid medium is continuously injected into the pressure chamber by using the fluid injection module, and ultra-high hydrostatic pressure treatment can be performed on the medical materials and / or raw materials for manufacturing medical materials placed in the pressure chamber, and a sufficient and uniform pressure can be applied to the medical materials and / or raw materials for manufacturing medical materials.

[0008] Optionally, the fluid injection module includes a fluid storage tank and an injection pipe. One end of the injection pipe is installed in communication with the pressure chamber, the other end of the injection pipe is connected to the fluid storage tank by a fluid pump, and a first control valve is installed at a position between the fluid pump and the pressure chamber of the injection pipe, and a pressure balance member is further installed in the pressure chamber.

[0009] Optionally, a temperature adjustment module is installed in the pressure chamber.

[0010] By adopting the above technical solution, in the process of pressure change, it is easy to cause fluctuations in the temperature of the fluid medium, and the temperature generally has an important influence on the performance of medical materials or raw materials for manufacturing medical materials. Therefore, when the temperature of the fluid medium rises or falls, the temperature adjustment module performs temperature adjustment on the fluid medium, makes the temperature of the fluid medium appropriate in the high-pressure treatment process, and thereby improves the performance of the finally obtained medical materials.

[0011] Optionally, the temperature adjustment module includes a fluid adjustment tank for containing cold fluid or hot fluid, a communication pipe is connected to the fluid adjustment tank, the communication pipe communicates with the fluid storage tank by a power pump, and a first temperature detector is installed in the pressure chamber.

[0012] By adopting the above technical solution, after the first temperature detector detects the temperature abnormality of the fluid medium in the pressure chamber, the automatic control system can control the operation of the power pump, and the fluid medium in the fluid adjustment tank enters the fluid storage tank, thereby mixing the two fluid media to neutralize the temperature, and adding the fluid medium with the appropriate temperature to the pressure chamber to adjust the temperature of the fluid medium in the pressure chamber, which is convenient and fast.

[0013] Optionally, a second temperature detector is disposed within the fluid storage tank.

[0014] By adopting the above technical solution, the second temperature detector can detect the temperature of the fluid medium in the fluid storage tank in real time, and control the amount of fluid medium added to the fluid storage tank, so that the temperature of the fluid medium in the fluid storage tank can be controlled more accurately, and the temperature of the fluid medium entering the pressure chamber can be easily controlled. Meanwhile, based on the previous test, the temperature change situation of the fluid medium in the pressure chamber is calculated during the pressurization process corresponding to the pressurization conditions, and then the temperature of the fluid in the fluid storage tank is directly controlled, so that the temperature of the fluid medium in the fluid storage tank is used to offset the temperature change difference value of the pressure chamber during the pressurization process, which is convenient and fast.

[0015] Optionally, the temperature control module includes a neutralization tube, the neutralization tube is connected to the pressure chamber, a fourth control valve is installed on a tube wall of the neutralization tube protruding from the pressure chamber, and a third temperature detector is installed in the pressure chamber.

[0016] By adopting the above technical solution, the third temperature detector detects the temperature inside the pressure chamber. If the temperature inside the pressure chamber is abnormal, the neutralization tube is directly used to add fluid medium of appropriate temperature to perform neutralization and adjust the temperature of the fluid medium inside the pressure chamber.

[0017] Optionally, the sealing module includes a first sealing head, which is inserted into the through groove and abuts against a groove wall of the through groove, and a first driving member is connected to the first sealing head for driving the movement of the first sealing head.

[0018] Optionally, there are two through grooves, and the sealing module includes a second sealing head and an adjusting plug, the second sealing head is inserted into one of the through grooves and abuts against a groove wall of the through groove, a second driving member is connected to the second sealing head for driving the sliding movement of the second sealing head, the adjusting plug enters the pressure chamber through the other through groove, the adjusting plug is slidably connected to the groove wall of the through groove, and the adjusting plug and the groove wall of the through groove are hermetically installed, and a driving module is connected to the adjusting plug for driving the sliding movement of the adjusting plug.

[0019] By adopting the above technical solution, the driving module can drive the movement of the adjusting plug, adjust the distance between the adjusting plug and the second sealing head, and adjust the volume of the pressure chamber, so that the pressure in the pressure chamber can be increased after the volume in the pressure chamber is reduced, and it is easy to realize pressurization of the pressure chamber.

[0020] Optionally, the driving module includes a driving base, a driving block and an interlocking block, the interlocking block is connected to one end of the adjusting plug protruding from the pressure chamber, a driving chamber is installed in the driving base, a sliding groove is installed through a chamber wall of the driving chamber, the interlocking block enters the driving chamber through the sliding groove, the interlocking block is slidably connected to a groove wall of the sliding groove, and the interlocking block and the groove wall of the sliding groove are hermetically installed, the driving block is installed at one end of the interlocking block entering the driving chamber, the driving block is slidably connected to a chamber wall of the driving chamber, the driving block divides the driving chamber into a first fluid chamber and a second fluid chamber independent from each other, and a circulation module is connected to the driving base for injecting fluid into the first fluid chamber and extracting fluid from the second fluid chamber or injecting fluid into the second fluid chamber and extracting fluid from the first fluid chamber.

[0021] By adopting the above technical solution, the fluid flows through the first fluid chamber and the second fluid chamber under the action of the circulation module, and thereby the pressure difference between the first fluid chamber and the second fluid chamber is utilized to slide the driving block in a predetermined direction, and when the driving block moves toward the pressure chamber, it moves the regulating plug toward the second sealing head, which makes it easy to realize pressurization of the pressure chamber.

[0022] Optionally, the circulation module includes a first circulation pipe, a second circulation pipe, a third circulation pipe and a fourth circulation pipe, one ends of the first circulation pipe and the second circulation pipe are all connected to the driving base, the first circulation pipe is connected to the first fluid chamber, the second circulation pipe is connected to the first fluid chamber, one end of the first circulation pipe away from the driving base and one end of the second circulation pipe away from the driving base are connected to a circulation pump, one end of the third circulation pipe is connected to a position of the first circulation pipe close to the driving base, The other end of the third circulation pipe is connected to a position of the second circulation pipe close to the circulation pump, one end of the fourth circulation pipe is connected to a position of the second circulation pipe close to the drive base, and the other end of the fourth circulation pipe is connected to a position of the first circulation pipe close to the circulation pump. Second control valves are installed at a position of the first circulation pipe between the third circulation pipe and the fourth circulation pipe, a position of the third circulation pipe close to the second circulation pipe, a position of the second circulation pipe between the third circulation pipe and the fourth circulation pipe, and a position of the fourth circulation pipe close to the second circulation pipe.

[0023] By adopting the above technical solution, the fourth circulation pipe, the fluid pump, and the third circulation pipe form a fluid flow path between the first fluid chamber and the second fluid chamber by closing the first and second valves and opening the third and fourth valves. By closing the third and fourth valves and opening the first and second valves, a fluid flow path is formed between the first circulation pipe, the circulation pump, and the second circulation pipe, and when the circulation pump is started, the fluid flow in the first and second fluid chambers can be realized according to a predetermined fluid flow path.

[0024] Optionally, the injection pipe is connected to a discharge pipe at a position between the first control valve and the pressure chamber, and a third control valve is installed in the discharge pipe. Effect of the Invention

[0025] As described above, the present application includes at least one of the following beneficial technical effects. 1. After the pressure chamber is sealed, the present invention allows the fluid medium to continue to be injected into the pressure chamber, so that the pressure chamber can be easily pressurized, thereby realizing hydrostatic pressure treatment for medical materials or raw materials for producing medical materials.

[0026] 2. In the present invention, after the pressure chamber is sealed, the pressure chamber can be easily pressurized by moving the adjusting plug and decreasing the volume of the pressure chamber.

[0027] 3. The present invention is equipped with a temperature adjustment module, which can adjust the temperature of the fluid medium in the pressure chamber at any time when the temperature inside the pressure chamber is too high or too low, thereby improving the pressure treatment effect on medical materials or raw materials for medical materials.

[0028] 4. A second temperature detector is installed in the fluid storage tank of the present application, which can detect the temperature of the fluid medium in the fluid storage tank in real time, and can not only cooperate with the temperature adjustment module to directly control the temperature of the fluid in the fluid storage tank, but also use the temperature of the fluid medium in the fluid storage tank to offset the temperature change difference value of the pressure chamber during the pressurization process. [Brief description of the drawings]

[0029] [Figure 1] 1 is a structural schematic diagram of a high-pressure device for medical material processing in Example 1 of the present application. [Diagram 2] FIG. 2 is a cross-sectional view taken along line AA in FIG. [Diagram 3] FIG. 11 is a structural schematic diagram of a high-pressure device for medical material processing in Example 2 of the present application. [Figure 4] FIG. 11 is a structural schematic diagram of a high-pressure device for medical material processing in Example 3 of the present application. [Diagram 5] FIG. 5 is a cross-sectional view taken along line BB in FIG. [Figure 6] FIG. 11 is a structural schematic diagram of a high-pressure device for medical material processing in Example 4 of the present application. [Figure 7] FIG. 7 is a cross-sectional view taken along line CC in FIG. [Figure 8]FIG. 11 is a structural schematic diagram of a high-pressure device for processing medical materials in Example 5 of the present application. [Figure 9] FIG. 9 is a cross-sectional view taken along line DD in FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0030] The present application will now be described in more detail with reference to the drawings.

[0031] Decellularized tissues are widely used in the field of tissue transplantation as biomedical materials because they have low immune rejection. Decellularization is a process for obtaining decellularized tissues, in which cells in foreign bodies or tissues are removed by chemical and physical methods, thereby producing and forming non-immunogenic or low-immunogenic biological tissue constructs.

[0032] This embodiment takes the production of decellularized tissue for biological medical materials as an example, and utilizes the high-pressure equipment for processing medical materials of the present application to perform hydrostatic pressure treatment on the biological tissue, remove cells in the biological tissue, and decontaminate and sterilize the biological tissue to produce decellularized tissue, in which the fluid medium may be physiological saline, etc. [Example 1]

[0033] Example 1 provides a high pressure device for medical material processing.

[0034] As shown in Figures 1 and 2, the high pressure equipment for medical material processing includes a pressure chamber 1 and a base 2. In this embodiment, the pressure chamber 1 is cylindrical, a through groove 11 is opened in the side wall of one end of the axial direction of the pressure chamber 1, and the other end of the pressure chamber 1 is sealed and installed. The pressure chamber 1 is fixedly connected to the base 2, a sealing module 3 is attached to the base 2, and a fluid injection module 4 is connected to the pressure chamber 1. The sealing module 3 is operated to open the through groove 11, biological tissue is put into the pressure chamber 1, the sealing module 3 is operated to seal the through groove 11, and then the fluid injection module 4 is operated to fill the pressure chamber 1 with a fluid medium, the fluid medium in this embodiment is physiological saline solution. When it is necessary to pressurize, the fluid injection module 4 is continuously operated to inject the fluid medium into the pressure chamber 1. In this process, as long as the volume in the pressure chamber 1 remains the same, the pressurization operation can be realized.

[0035] As shown in Figures 1 and 2, the sealing module 3 includes a first sealing head 31, and a first driving member 32 is fixedly connected to the base 2. The first driving member 32 in this embodiment can drive a cylinder, a hydraulic cylinder, etc. The first driving module 7 in this embodiment is a driving cylinder, the driving end of the first driving member 32 faces the through groove 11 along the axial direction of the pressure chamber 1, the first sealing head 31 includes a first sealing plate 33 fixedly connected to the driving end of the first driving member 32 and a first sealing plug 34 fixedly connected to one side wall of the first sealing plate 33 away from the first driving member 32, the first sealing plug 34 is inserted into the through groove 11 and abuts against the groove wall of the through groove 11, and a first sealing sheet 35 is fixedly connected to the side wall of the first sealing plate 33 facing the pressure chamber 1, and the first sealing sheet 35 abuts against the end wall of the pressure chamber 1. By activating the first driving member 32 and moving the first sealing plate 33 and the first sealing plug 34 away from the pressure chamber 1, the through groove 11 can be opened, and by activating the first driving member 32, the first sealing plug 34 is inserted into the through groove 11 and the end walls of the first sealing plate 33 and the pressure chamber 1 are abutted, the pressure chamber 1 can be sealed.

[0036] 1 and 2, the fluid injection module 4 in this embodiment includes a fluid storage tank 41 and an injection tube 42, one end of the injection tube 42 is fixedly connected to the first sealing head 31, the injection tube 42 enters the pressure chamber 1 after passing through the first sealing plate 33 and the first sealing plug 34, the first sealing plate 33 and the first sealing plug 34 are both hermetically connected to the outer wall of the injection tube 42, the other end of the injection tube 42 is connected to a fluid pump 43, one end of the fluid pump 43 away from the injection tube 42 is connected to a lift pipe 44, and one end of the lift pipe 44 away from the fluid pump 43 enters the fluid storage tank 41. A first control valve 45 is installed at a position of the injection tube 42 between the fluid pump 43 and the first sealing plate 33. A discharge pipe 46 is connected to the injection tube 42 at a position between the first control valve 45 and the first sealing plate 33, and a third control valve 47 is installed at the discharge pipe 46. Moreover, in this embodiment, a pressure balance member 5 is further attached to the first sealing head 31, the pressure balance member 5 includes a balance pipe 51 fixedly connected to the first sealing head 31, the balance pipe 51 enters the pressure chamber 1 after passing through the first sealing plate 33 and the first sealing plug 34, the first sealing plate 33 and the first sealing plug 34 are both hermetically connected to the outer pipe wall of the balance pipe 51, and a pressure balance valve 52 is attached to the pipe wall of the balance pipe 51 protruding from the first sealing head 31. In this embodiment, a pressure detector 48 is attached to the first sealing plug 34.

[0037] The operating principle of the high pressure equipment for medical material processing in the first embodiment is as follows. The biological tissue is placed in the pressure chamber 1, the first driving member 32 is started, the first sealing head 31 is inserted into the through groove 11, and the first sealing head 31 and the first sealing plate 33 seal the through groove 11 of the pressure chamber 1. The pressure balance valve 52 is opened, the fluid pump 43 is started, the fluid medium in the fluid storage tank 41 is filled into the pressure chamber 1, and then the pressure balance valve 52 is closed. According to the need of the operating state, pressure is continued to be applied to the pressure chamber 1, and since the volume of the pressure chamber 1 remains the same, the pressure of the pressure chamber 1 increases, and the decellularization process of the biological tissue can be performed until the pressure detector 48 detects that the pressure of the pressure chamber 1 reaches the requirement. After the high pressure process is completed, the pressure is released, and then the third control valve 47 is opened to discharge the fluid medium in the pressure chamber 1. Finally, the first driving member 32 is started, the first sealing head 31 is moved away from the pressure chamber 1, and the biological tissue after the process can be taken out. [Example 2]

[0038] As shown in FIG. 3, the high pressure equipment for medical material processing, the second embodiment is different from the first embodiment as follows. A second temperature detector 62 is fixedly installed in the fluid storage tank 41. Before performing full-scale high pressure processing, a simulated pressurization operation is performed under a predetermined pressurization condition, and the temperature change value of the fluid medium in the pressure chamber 1 is obtained during the entire pressurization process, and the temperature range of the fluid medium required for the fluid storage tank 41 is estimated based on this change value. When the pressurization operation is performed in earnest, the second temperature detector 62 detects the temperature of the fluid medium in the fluid storage tank 41 in real time, and if an abnormality occurs in the temperature of the fluid medium in the fluid storage tank 41, the temperature of the fluid medium in the fluid storage tank 41 can be directly adjusted. The temperature adjustment method of the fluid medium in the fluid storage tank 41 may be neutralized by adding a fluid medium of an appropriate temperature, or may be adjusted by using equipment such as a cooler or a heating tube. [Example 3]

[0039] As shown in Figures 4 and 5, in the high-pressure equipment for medical material processing, the third embodiment is different from the second embodiment as follows. A temperature adjustment module 6 is attached to the pressure chamber 1 of this embodiment. The temperature adjustment module 6 includes a fluid adjustment tank 61, in which a cold fluid or a hot fluid is accommodated, and the cold fluid is accommodated in the fluid adjustment tank 61 of this embodiment, and the cold fluid and the fluid medium in the fluid storage tank 41 are the same material. A communication pipe 63 is connected to the fluid adjustment tank 61, and the communication pipe 63 communicates with the fluid storage tank 41 via a power pump 64, and a first temperature detector 65 is fixedly attached to the side wall of the first sealing plug 34 that enters the pressure chamber 1.

[0040] The working principle of the high pressure equipment for medical material processing in the third embodiment is as follows: the first temperature detector 65 detects the temperature of the fluid medium in the pressure chamber 1, and when it finds that the temperature in the pressure chamber 1 is too high, the automatic control system turns on the power pump 64, and the cold fluid in the fluid adjustment tank 61 is injected into the fluid storage tank 41 to perform neutralization, while the second temperature detector 62 detects the temperature of the fluid storage tank 41 in real time. When the temperature of the fluid medium in the fluid storage tank 41 is appropriate, the automatic control system starts the fluid pump 43 to add a fluid medium with a relatively low temperature to the pressure chamber 1 until the temperature in the pressure chamber 1 reaches an appropriate range. Or add a fluid medium with a relatively low temperature to the pressure chamber 1, under the premise of ensuring the operating safety of the pressure chamber 1, at the same time, open the third control valve 47 to discharge the fluid medium with a relatively high temperature from the pressure chamber 1, and further adjust the temperature of the fluid medium in the pressure chamber 1 more quickly. [Example 4]

[0041] As shown in Figures 6 and 7, the high pressure equipment for medical material processing, the difference between Example 4 and Example 1 is as follows: A temperature control module 6 is attached to the pressure chamber 1 in this embodiment, the temperature control module 6 includes a neutralization tube 311, the neutralization tube 311 is attached to the first sealing head 31, the neutralization tube 311 enters the pressure chamber 1 after passing through the first sealing plate 33 and the first sealing plug 34, the first sealing plate 33 and the first sealing plug 34 are both hermetically connected to the outer tube wall of the neutralization tube 311, and a fourth control valve 312 is attached to the tube wall of the neutralization tube 311 protruding from the pressure chamber 1. In this embodiment, a third temperature detector 313 is attached to one side of the first sealing plug 34 away from the first sealing plate 33. The third temperature detector 313 detects the temperature in the pressure chamber 1 in real time. If the temperature in the pressure chamber 1 is too high or too low, the fourth control valve 312 is opened, and a fluid medium is injected into the pressure chamber 1 through the neutralization tube 311 to neutralize the temperature in the pressure chamber 1. Then, the pressure chamber 1 is normally pressurized until the temperature in the pressure chamber 1 becomes appropriate. [Example 5]

[0042] As shown in Figures 8 and 9, the high pressure equipment for medical material processing, the difference between Example 5 and Example 3 is as follows. In this embodiment, one through groove 11 penetrates each of both axial end side walls of the pressure chamber 1, and for ease of explanation, one through groove 11 is named as the material through groove 12, and the other through groove 11 is named as the adjustment groove 13. The sealing module 3 includes a second sealing head 36 and an adjustment plug 37, and a second driving member 38 is attached to the base 2 at a position opposite to the material through groove 12, and the second driving member 38 can be a driving cylinder, a hydraulic cylinder, etc., and the second driving member 38 in this embodiment is a driving cylinder. The second sealing head 36 in this embodiment includes a second sealing plate 361 fixedly connected to the driving end of the second driving member 38 and a second sealing plug 362 fixedly connected to one side wall of the second sealing plate 361 facing the pressure chamber 1, and the second sealing plug 362 is inserted into the material through groove 12 and abuts against the groove wall of the material through groove 12. The second gasket 39 is fixedly connected to one side of the second sealing plate 361 facing the pressure chamber 1, and the second sealing plate 361 abuts against the end wall of the pressure chamber 1. In addition, the balance pipe 51 and the injection pipe 42 are both attached to the second sealing head 36, and the first temperature detector 65 and the pressure detector 48 are both attached to one side wall of the second sealing plug 362 facing away from the second sealing plate 361.

[0043] 8 and 9, the adjustment plug 37 enters the pressure chamber 1 through the adjustment groove 13, the adjustment plug 37 slides and connects with the groove wall of the adjustment groove 13, and the adjustment plug 37 is hermetically installed between the groove wall of the through groove 11. A driving module 7 that drives the sliding movement of the adjustment plug 37 is attached to the base 2.

[0044] 8 and 9, the driving module 7 in this embodiment includes a driving base 71, a driving block 72 and an interlocking block 73, the driving base 71 is fixedly connected to the base 2 and faces the adjustment groove 13, a driving chamber 74 is installed in the driving base 71, and a sliding movement groove 75 is installed in a chamber wall close to the driving chamber 74 and facing the material through groove 12. The interlocking block 73 is fixedly connected to one end protruding from the pressure chamber 1 of the adjustment plug 37, the interlocking block 73 enters the driving chamber 74 through the sliding movement groove 75, and the interlocking block 73 and the groove wall of the sliding movement groove 75 are connected by sliding movement, and the space between the interlocking block 73 and the groove wall of the sliding movement groove 75 is sealed. The driving block 72 is fixedly connected to one end of the interlocking block 73 which enters the driving chamber 74, the peripheral wall of the driving block 72 is slidably connected to and hermetically installed with the chamber wall of the driving chamber 74, the driving block 72 divides the driving chamber 74 into a first fluid chamber 76 and a second fluid chamber 77 which are independent from each other, the first fluid chamber 76 is located on one side of the second fluid chamber 77 away from the pressure chamber 1. Moreover, a pressure detector 78 is fixedly attached to the chamber walls of both the first fluid chamber 76 and the second fluid chamber 77, and an adjustment pipe 79 is connected to the chamber walls of both the first fluid chamber 76 and the second fluid chamber 77, and a pressure adjustment valve 791 is attached to the pipe wall where the adjustment pipe 79 protrudes from the driving base 71.

[0045] As shown in Figures 8 and 9, a circulation module 8 is attached to the drive base 71, and the circulation module 8 includes a first circulation pipe 81, a second circulation pipe 82, a third circulation pipe 83 and a fourth circulation pipe 84, one ends of the first circulation pipe 81 and the second circulation pipe 82 are all connected to the drive base 71, the first circulation pipe 81 is connected to the first fluid chamber 76 and the second circulation pipe 82 is connected to the first fluid chamber 76, a circulation pump 85 is connected to one end of the first circulation pipe 81 away from the drive base 71, and one end of the circulation pump 85 away from the first circulation pipe 81 is connected to one end of the second circulation pipe 82 away from the drive base 71.

[0046] 8 and 9, one end of the third circulation pipe 83 communicates with the first circulation pipe 81 at a position close to the drive base 71, and one end of the third circulation pipe 83 remote from the first circulation pipe 81 communicates with the second circulation pipe 82 at a position close to the circulation pump 85. One end of the fourth circulation pipe 84 communicates with the second circulation pipe 82 at a position close to the drive base 71, and one end of the fourth circulation pipe 84 remote from the second circulation pipe 82 communicates with the first circulation pipe 81 at a position close to the circulation pump 85. Second control valves 86 are attached at a position between the third circulation pipe 83 and the fourth circulation pipe 84 of the first circulation pipe 81, a position close to the second circulation pipe 82 of the third circulation pipe 83, a position between the third circulation pipe 83 and the fourth circulation pipe 84 of the second circulation pipe 82, and a position close to the second circulation pipe 82 of the fourth circulation pipe 84. For ease of explanation, the second control valve 86 in the first circulation pipe 81 is named the first valve 861, the second control valve 86 in the second circulation pipe 82 is named the second valve 862, the second control valve 86 in the third circulation pipe 83 is named the third valve 863, and the second control valve 86 in the fourth circulation pipe 84 is named the fourth valve 864.

[0047] The high-pressure equipment for medical material processing in Example 5 of the present application includes two pressurizing methods, one of which is to apply pressure by continuously adding fluid medium to the pressure chamber 1 while maintaining the position of the adjustment plug 37.

[0048] Another pressurizing device does not continuously inject fluid medium into the pressure chamber 1, closes the first valve 861 and the second valve 862, opens the third valve 863 and the fourth valve 864, turns on the circulation pump 85, and allows the liquid in the second fluid chamber 77 to enter the first fluid chamber 76 through the fourth circulation pipe 84, the fluid pump 43, and the third circulation pipe 83, moving the driving block 72 toward the pressure chamber 1, and the interlocking block 73 further moves the adjusting plug 37 toward the second sealing plug 362, reducing the volume of the pressure chamber 1 and realizing pressurization. When pressure release is required, closes the third valve 863 and the fourth valve 864, starts the circulation pump 85, and opens the first valve 861 and the second valve 862, allowing the liquid in the first fluid chamber 76 to enter the second fluid chamber 77 through the first circulation pipe 81, the circulation pump 85, and the second circulation pipe 82, and the driving block 72 moves the adjusting plug 37 away from the second sealing plug 362.

[0049] In addition, in order to increase safety during pressurization, the pressure detector 78 detects the pressure in the first fluid chamber 76 and the second fluid chamber 77 in real time, and if the pressure is abnormal, the pressure can be adjusted by the pressure adjustment valve 791.

[0050] The above are preferred embodiments of the present application, and the scope of protection of the present application is not limited based on these embodiments. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application. [Explanation of symbols]

[0051] 1...pressure chamber, 11...through groove, 12...material through groove, 13...adjusting groove, 2...base, 3...sealing module, 31...first sealing head, 311...neutralizing tube, 312...fourth control valve, 313...third temperature detector, 32...first driving member, 33...first sealing plate, 34...first sealing plug, 35...first sealing seat, 36...second sealing head, 361...second sealing plate, 362...second sealing plug, 37...adjusting plug, 38...second driving member, 39...second gasket, 4...fluid injection module, 41...fluid storage tank, 42...injection tube, 43...fluid pump, 44...lifting tube, 45...first control valve, 46...discharge tube, 47...third control valve, 48...pressure detector, 5...pressure balance member, 51. ..balance pipe, 52...pressure balance valve, 6...temperature adjustment module, 61...fluid adjustment tank, 62...second temperature detector, 63...connecting pipe, 64...power pump, 65...first temperature detector, 7...drive module, 71...drive base, 72...drive block, 73...interlocking block, 74...drive chamber, 75...slide movement groove, 76...first fluid chamber, 77...second fluid chamber, 78...pressure detector, 79...regulating pipe, 791...pressure regulating valve, 8...circulation module, 81...first circulation pipe, 82...second circulation pipe, 83...third circulation pipe, 84...fourth circulation pipe, 85...circulation pump, 86...second control valve, 861...first valve, 862...second valve, 863...third valve, 864...fourth valve.

Claims

1. A high-pressure equipment for processing medical materials, comprising a pressure chamber (1) for placing medical materials and / or raw materials for manufacturing medical materials, at least one through groove (11) extending through a side wall of the pressure chamber (1), the high-pressure equipment further comprising a sealing module (3) for sealing the through groove (11), and a fluid injection module (4) connected to the pressure chamber (1).

2. The high-pressure equipment for medical material processing as described in claim 1, characterized in that the fluid injection module (4) includes a fluid storage tank (41) and an injection pipe (42), one end of the injection pipe (42) is installed in communication with the pressure chamber (1), the other end of the injection pipe (42) is connected to the fluid storage tank (41) by a fluid pump (43), a first control valve (45) is installed at a position of the injection pipe (42) between the fluid pump (43) and the pressure chamber (1), and a pressure balance member (5) is further installed in the pressure chamber (1).

3. 3. The high pressure equipment for medical material processing according to claim 2, further comprising a second temperature detector (62) installed in the fluid storage tank (41).

4. 2. The high pressure equipment for medical material processing according to claim 1, characterized in that a temperature adjustment module (6) is installed in the pressure chamber (1).

5. The high-pressure equipment for medical material processing as described in claim 4, characterized in that the temperature adjustment module (6) includes a fluid adjustment tank (61) for storing a cold fluid or a hot fluid, a connecting pipe (63) is connected to the fluid adjustment tank (61), the connecting pipe (63) is connected to the fluid injection module (4) by a powered pump (64), and a first temperature detector (65) is installed in the pressure chamber (1).

6. The high-pressure equipment for medical material processing as described in claim 4, characterized in that the temperature control module (6) includes a neutralization pipe (311), the neutralization pipe (311) is connected to the pressure chamber (1), a fourth control valve (312) is installed on the pipe wall of the neutralization pipe (311) protruding from the pressure chamber (1), and a third temperature detector (313) is installed in the pressure chamber (1).

7. The high-pressure equipment for processing medical materials as described in claim 1, characterized in that the sealing module (3) includes a first sealing head (31), which is inserted into the through groove (11) and abuts against the groove wall of the through groove (11), and a first driving member (32) is connected to the first sealing head (31) for driving the movement of the first sealing head (31).

8. 2. The high pressure equipment for medical material processing according to claim 1, characterized in that there are two through grooves (11), the sealing module (3) includes a second sealing head (36) and an adjusting plug (37), the second sealing head (36) is inserted into one of the through grooves (11) and abuts against a groove wall of the through groove (11), a second driving member (38) for driving the sliding movement of the second sealing head (36) is connected to the second sealing head (36), the adjusting plug (37) enters the pressure chamber (1) through the other through groove (11), the adjusting plug (37) is slidably connected to the groove wall of the through groove (11), and a seal is provided between the adjusting plug (37) and the groove wall of the through groove (11), and a driving module (7) for driving the sliding movement of the adjusting plug (37) is connected to the adjusting plug (37).

9. The driving module (7) includes a driving base (71), a driving block (72) and an interlocking block (73), the interlocking block (73) is connected to one end of the adjusting plug (37) protruding from the pressure chamber (1), a driving chamber (74) is installed in the driving base (71), a sliding groove (75) is installed in the chamber wall of the driving chamber (74) and penetrates the driving chamber (74), the interlocking block (73) enters the driving chamber (74) through the sliding groove (75), the interlocking block (73) slides and connects with the groove wall of the sliding groove (75), and the space between the interlocking block (73) and the groove wall of the sliding groove (75) is sealed, and the driving block 9. The high pressure equipment for medical material processing according to claim 8, characterized in that a drive base (71) is installed at one end of the interlocking block (73) entering the driving chamber (74), the driving block (72) is connected to a chamber wall of the driving chamber (74) by sliding movement, the driving block (72) divides the driving chamber (74) into a first fluid chamber (76) and a second fluid chamber (77) independent of each other, and a circulation module (8) is connected to the driving base (71) for injecting fluid into the first fluid chamber (76) and extracting fluid from the second fluid chamber (77) or for injecting fluid into the second fluid chamber (77) and extracting fluid from the first fluid chamber (76).

10. The circulation module (8) includes a first circulation pipe (81), a second circulation pipe (82), a third circulation pipe (83) and a fourth circulation pipe (84), one end of each of the first circulation pipe (81) and the second circulation pipe (82) is connected to the drive base (71), the first circulation pipe (81) is connected to the first fluid chamber (76), the second circulation pipe (82) is connected to the first fluid chamber (76), one end of the first circulation pipe (81) remote from the drive base (71) and one end of the second circulation pipe (82) remote from the drive base (71) are connected by a circulation pump (85), one end of the third circulation pipe (83) is connected to a position of the first circulation pipe (81) close to the drive base (71), and the other end of the third circulation pipe (83) is connected to the second circulation 10. The high-pressure equipment for treating medical materials according to claim 9, wherein one end of the fourth circulation pipe (84) is connected to a position of the second circulation pipe (82) close to the circulation pump (85), one end of the fourth circulation pipe (84) is connected to a position of the second circulation pipe (82) close to the drive base (71), and the other end of the fourth circulation pipe (84) is connected to a position of the first circulation pipe (81) close to the circulation pump (85), and second control valves (86) are installed at a position of the first circulation pipe (81) between the third circulation pipe (83) and the fourth circulation pipe (84), a position of the third circulation pipe (83) close to the second circulation pipe (82), a position of the second circulation pipe (82) between the third circulation pipe (83) and the fourth circulation pipe (84), and a position of the fourth circulation pipe (84) close to the second circulation pipe (82).

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