Mussel-inspired tissue adhesives and methods for their use
A zein-based adhesive with catechol or gallol compounds and crosslinkers provides strong, biocompatible, and cost-effective tissue sealing, overcoming the limitations of existing mussel-inspired adhesives by ensuring adhesion in biological fluids and rapid curing.
Patent Information
- Application Number
- JP2025509147
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-08-19
- Filing Date
- 2023-08-21
- Publication Date
- 2025-08-22
AI Technical Summary
There is a need for natural, biodegradable, easily synthesized, scalable, low-cost adhesives that exhibit strong adhesion even when exposed to biological fluids and have short cure times, addressing the limitations of existing mussel-inspired adhesives that are expensive, difficult to synthesize, require curing additives, and have toxicity issues.
A biocompatible adhesive composed of zein and one or more catechol- or gallol-containing compounds, optionally with an iron or interfacial crosslinker, formulated at a neutral or near-neutral pH, which can include catechol or gallol-containing compounds such as tannic acid, caffeic acid, and transglutaminase, to promote strong adhesive bonding with tissues.
The adhesive demonstrates high tensile strength up to 20 MPa, effective tissue sealing, and biocompatibility, with short cure times and the ability to bond under biological fluid pressure, making it suitable for various tissue applications.
Smart Images
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