Multi-lane Extraction Drawer

Abstract

The automated analyzer can include a drawer assembly. The drawer assembly can include a two-lane drawer including a pipette tip station configured to accommodate two pipette tip holders, an extraction vessel station configured to accommodate two extraction vessel holders, and an amplification plate station configured to accommodate two amplification plates. The drawer assembly can include an extractor module positioned relative to the extraction vessel station, the extractor module including a magnet configured to apply a magnetic field to the extraction vessel holders of the two extraction vessel holders.

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Patent Application No. 63 / 422,700, filed November 4, 2022, which is hereby incorporated by reference in its entirety.

[0002] The technology described herein relates generally to automated diagnostic analyzers including components thereof. In some aspects, the technology relates more specifically to multi-lane extraction drawers. [Background technology]

[0003] Diagnostic testing of biological samples is beneficial to the healthcare industry's efforts to quickly and effectively diagnose and treat disease. Clinical laboratories that perform such diagnostic tests already receive hundreds or even thousands of samples daily due to ever-increasing demand. The challenge of managing such large numbers of samples has been assisted by the automation of sample analysis. Automated sample analysis is typically performed by automated analyzers, which are generally self-contained systems that perform multi-step processing on biological samples to obtain diagnostic results.

[0004] Some current automated clinical analyzers offer users a wide variety of automated tests or assays that can be performed on provided samples. Additionally, when samples arrive at the laboratory, they are often not ready for analysis. To prepare a sample for testing by an automated analyzer, a laboratory technician typically transfers an aliquot of the sample from the primary container in which it was received by the laboratory to a secondary container appropriate for the analyzer. Additionally, the technician must typically know which test will be performed on the sample so that the technician can select test-specific reagents or diluents to pair with the sample. This can be time-consuming and can lead to operator error and exposure to infectious diseases.

[0005] Pre-analytical systems exist that prepare samples for analysis and also help remove operators from the workflow between laboratory sample receipt and analyzer test results, but many of these systems still require significant technician involvement before loading the sample into the pre-analytical system, after the sample has been prepared by the pre-analytical system, and after the analyzer has completed its analysis.

[0006] For example, some pre-analytical systems may automatically transfer an aliquot of sample from a first container to a second container, but such systems often require a technician to manually match the identification codes of the first and second containers before loading them into the system, which can be time-consuming and prone to error.

[0007] In addition, many of these systems do not allow for integration with one or more analyzers, and vice versa. In this regard, a technician must be present to manually transfer samples from the pre-analytical system to the analyzer and from the analyzer to a storage location once the analysis is complete. This requires skilled labor to perform a monotonous task and can be distracting in that the technician must constantly monitor the progress of samples in the pre-analytical system and analyzer so that they are ready to transfer samples when ready to minimize downtime.

[0008] Furthermore, current pre-analytical systems typically prepare samples at a different rate than the analyzer evaluates such samples. This further complicates integration between the pre-analytical system and the analyzer. In this regard, a technician may be required to constantly track samples prepared by the pre-analytical system until an entire batch of samples has been accumulated for manual transfer to the analyzer. Alternatively, the technician may transfer partial batches to the analyzer, which can reduce the productivity of the analyzer. Summary of the Invention [Problem to be solved by the invention]

[0009] That is, although current automated pre-analytical systems and analyzers are beneficial to clinical laboratories, there is room for better integration and automation of various systems. [Means for solving the problem]

[0010] The present disclosure describes devices, systems, and methods for sample processing and analysis.

[0011] In some embodiments, a two-lane drawer assembly is provided. The two-lane drawer assembly can include a two-lane drawer. The two-lane drawer can include a pipette tip station configured to accommodate two pipette tip holders. The two-lane drawer can include an extraction vessel station configured to accommodate two extraction vessel holders. The two-lane drawer can include an amplification plate station configured to accommodate two amplification plates. The two-lane drawer assembly can include an extractor module positioned relative to the extraction vessel station. In some embodiments, the extractor module includes a magnet configured to apply a magnetic field to the extraction vessel holders of the two extraction vessel holders.

[0012] In some embodiments, the extractor module is configured to process samples from two extraction vessel holders simultaneously. In some embodiments, the extractor module is configured to move relative to the two extraction vessel holders. In some embodiments, the extractor module is configured to move up and down along one or more rails. In some embodiments, the two-lane drawer includes a retention feature configured to extend over a portion of the pipette tip station and the extraction vessel station. In some embodiments, the two-lane drawer includes a latching mechanism including a push-to-close latch. In some embodiments, the two-lane drawer includes a kick-out mechanism configured to facilitate sliding or extending the two-lane drawer. In some embodiments, the two-lane drawer includes a telescopic slide. In some embodiments, the two-lane drawer assembly includes two pipette tip holders, two extraction vessel holders, and two amplification plates. In some embodiments, the two-lane drawer assembly includes three two-lane drawers. In some embodiments, the two-lane drawer assembly includes a tip drawer configured to accommodate five pipette tip holders.

[0013] In some embodiments, a two-lane drawer assembly is provided. The two-lane drawer assembly can include a two-lane drawer. The two-lane drawer can include a pipette tip station configured to accommodate two pipette tip holders. The two-lane drawer can include an extraction vessel station configured to accommodate two extraction vessel holders. The two-lane drawer can include an amplification plate station configured to accommodate two amplification plates. The two-lane drawer assembly can include an extractor module positioned relative to the extraction vessel station. In some embodiments, the extractor module includes a magnet configured to apply a magnetic field to the extraction vessel holders of the two extraction vessel holders.

[0014] In some embodiments, the extractor module is configured to process samples from one extraction vessel holder. In some embodiments, the extractor module is configured to move up and down relative to two extraction vessel holders. In some embodiments, the extractor module is configured to move up and down along one or more rails. In some embodiments, the two-lane drawer includes a retention feature configured to extend over a portion of the pipette tip station and the extraction vessel station. In some embodiments, the two-lane drawer includes a latching mechanism including a push-to-close latch. In some embodiments, the two-lane drawer includes a kick-out mechanism configured to facilitate sliding or extending the two-lane drawer. In some embodiments, the two-lane drawer includes a telescopic slide. In some embodiments, the two-lane drawer assembly can include two pipette tip holders, two extraction vessel holders, and two amplification plates. In some embodiments, the two-lane drawer assembly can include three two-lane drawers. In some embodiments, the two-lane drawer assembly can include a tip drawer configured to accommodate five pipette tip holders. [Brief explanation of the drawings]

[0015] [Figure 1] 1 is a front perspective view of a high throughput diagnostic system according to an embodiment of the present disclosure. [Figure 2] FIG. 2 is a front perspective view of the analyzer of the high throughput diagnostic system of FIG. 1 with the outer housing removed. [Figure 3] 3 is another front perspective view of the analyzer of FIG. 2. [Figure 4A] FIG. 2 is a diagram of the processing deck and its components of the analyzer of the high-throughput diagnostic system of FIG. 1. [Figure 4B] FIG. 2 is a diagram of the processing deck and its components of the analyzer of the high-throughput diagnostic system of FIG. 1. [Figure 4C]FIG. 2 is a diagram of the processing deck and its components of the analyzer of the high-throughput diagnostic system of FIG. 1. [Figure 4D] FIG. 2 is a diagram of the processing deck and its components of the analyzer of the high-throughput diagnostic system of FIG. 1. [Figure 4E] FIG. 2 is a diagram of the processing deck and its components of the analyzer of the high-throughput diagnostic system of FIG. 1. [Figure 4F] FIG. 2 is a diagram of the processing deck and its components of the analyzer of the high-throughput diagnostic system of FIG. 1. [Figure 5A] 1 is a diagram of an embodiment of a two-lane drawer and extractor in accordance with the present disclosure. FIG. [Figure 5B] 1 is a diagram of an embodiment of a two-lane drawer and extractor in accordance with the present disclosure. FIG. [Figure 5C] 1 is a diagram of an embodiment of a two-lane drawer and extractor in accordance with the present disclosure. FIG. [Figure 6A] 5B is a diagram of the two-lane drawer of FIG. 5A in relation to an analyzer according to the present disclosure. [Figure 6B] 5B is a diagram of the two-lane drawer of FIG. 5A in relation to an analyzer according to the present disclosure. [Figure 6C] 5B is a diagram of the two-lane drawer of FIG. 5A in relation to an analyzer according to the present disclosure. [Figure 7] 1A and 1B are diagrams of an embodiment of a two-lane drawer according to the present disclosure. [Figure 8] 1A-1C are diagrams of an embodiment of a three lane drawer in accordance with the present disclosure. [Figure 9A] 1A-1C are diagrams of an embodiment of a six-lane drawer and stationary retention housing in accordance with the present disclosure. [Figure 9B] 1A-1C are diagrams of an embodiment of a six-lane drawer and stationary retention housing in accordance with the present disclosure. [Figure 10A] FIG. 1 is a diagram of an extractor scissors lift in accordance with the present disclosure. [Figure 10B] FIG. 1 is a diagram of an extractor scissors lift in accordance with the present disclosure. [Figure 10C]FIG. 1 is a diagram of an extractor scissors lift in accordance with the present disclosure. [Figure 11] FIG. 1 is a diagram of an extractor pusher according to the present disclosure. DETAILED DESCRIPTION OF THE INVENTION

[0016] Disclosed embodiments of the present invention provide devices, systems, and methods capable of processing samples. Some embodiments provide a multi-lane drawer that holds consumables used during processing, such as two or more pipette tip holders, two or more extraction vessel holders, and two or more amplification plates. Some embodiments include one or more extractor modules configured to apply a magnetic field to the extraction vessels within the multi-lane drawer. Some embodiments provide a plate sealer that seals the amplification plates against processing. As described herein, the multi-lane drawer and plate sealer can be components of a high-throughput system configured to process multiple samples with reduced technician involvement. The systems described herein can prepare samples for analysis while automating one or more steps between sample receipt and generation of test results.

[0017] FIG. 1 illustrates a high-throughput system 00 according to an embodiment of the present disclosure. The high-throughput system 00 can include a first analyzer 2000. The high-throughput system 00 can include a second analyzer 4000. The high-throughput system 00 can include any number of analyzers. The high-throughput system 00 can include a pre-analytical system 10. The analyzers 2000, 4000 and the pre-analytical system 10 are modular such that they can be physically connected and disconnected from one another. The analyzers 2000, 4000 and the pre-analytical system 10 are modular such that they can be electrically connected and disconnected from one another. In some embodiments, the analyzers 2000 and 4000 can have the same configuration. The analyzers 2000 and 4000 can have the same functionality. The analyzers 2000 and 4000 can be replicas of one another. The pre-analytical system 10 can be coupled to at least two of a plurality of identical analyzers. In some embodiments, the analyzers 2000 and 4000 can have different configurations. The analyzers 2000 and 4000 can have different functions. The analyzers 2000 and 4000 can perform different operations. The analyzers 2000 and 4000 can analyze different assays. The pre-analytical system 10 can be coupled to at least two different analyzers. The modularity of the pre-analytical system 10 allows the pre-analytical system 10 to be coupled to any analyzer configured as described above. As shown, the first analyzer 2000 and the second analyzer 4000 are arranged in a linear configuration on either side of the pre-analytical system 10. In other embodiments, the pre-analytical system 10 can be located at one end of the high-throughput system 00. The pre-analytical system 10 and the analyzers 2000, 4000 can be arranged in any physical configuration. The analyzer 4000 can be coupled to either side of the pre-analytical system 10.

[0018] The pre-analysis system 10 can include a sample container shuttle transport assembly 4250, as shown in FIG. 4A. The sample container shuttle transport assembly 4250 can transfer sample containers to one or more analyzers 2000, 4000. The sample container shuttle transport assembly 4250 of the pre-analysis system 10 can extend toward the analyzer 4000 when the analyzer 4000 is positioned to the left of the system 10 (as illustrated in FIG. 1). In other embodiments, the sample container shuttle transport assembly 4250 of the pre-analysis system 10 can extend toward the analyzer 4000 when the analyzer 4000 is positioned to the right of the system 10. In some embodiments, the sample container shuttle transport assembly 4250 terminates at the inlet of the analyzer 2000, 4000. In other embodiments, the sample container shuttle transport assembly 4250 extends into the analyzer 2000, 4000. The analyzers 2000, 4000 may have a conveyor that can continue the path of each shuttle transport assembly 4250 through the analyzers 2000, 4000. The sample vessel shuttle transport assembly 4250 may be a rack or carrier structure having a plurality of receptacles, each sized and configured to receive a sample vessel. The sample vessel shuttle transport assembly 4250 may include an actuator that provides movement of the rack or carrier structure. The high-throughput system 00 may include an opening 120 for receiving a rack or carrier structure having a plurality of sample vessels. The analyzers 2000, 4000 may include one or more sub-modules 2110, 2120, 2130. These sub-modules may be the same or different from one another.

[0019] The high throughput system 00 may include an overall system display interface 1332. Data may be entered and viewed through a graphical user interface ("GUI") that may be displayed on the display interface 1332. Data may be entered and viewed through a graphical user interface associated with the analyzers 2000, 4000, among others. Similarly, data may be entered from a vision system of a multipurpose robot. Additionally, data may be entered from a scanner within the pre-analytical system 10. Data may be acquired by sensors, such as door sensors, to obtain information regarding certain conditions and activities occurring within the analyzers 2000, 4000. Data may be acquired by sensors, such as temperature sensors, to obtain information regarding certain conditions and activities occurring within the analyzers 2000, 4000. Data regarding the location of one or more consumables may be acquired. Data may be acquired regarding the location of sample containers.

[0020] The pre-analytical system 10 can be an automated system for pre-analytical processing of samples to be assayed. The analyzers 2000, 4000 can be modular systems configured to operate in cooperation with the pre-analytical system 10. The analyzers 2000, 4000 can be configured for modular connection to the pre-analytical system 10. The analyzers 2000, 4000 can be configured for high-throughput processing and analysis of samples. The analyzer 4000 is described in more detail below. The analyzer 2000 can include any of the features described herein.

[0021] 2 and 3 illustrate an analyzer 4000. The analyzer 4000 can include a structural frame 4011 comprised of several support components. The support components can be, by way of example, segments of metal piping. The frame 4011 is configured to support and define various decks or levels for sample processing and analysis. The decks can include an auxiliary deck 4012. The decks can include a processing deck 4014. The decks can include a multipurpose robot deck 4016. The analyzer 4000 can include a housing or shell that surrounds the frame 4011. This housing is shown in FIG. 1. The analyzer 4000 can include two detectors 4260a, 4260b. The detectors 4260a, 4260b can be positioned at opposite ends of the analyzer 4000. The detectors 4260a, 4260b can have cavities facing the center of the analyzer 4000. The detectors 4260a, 4260b can have a housing that receives the sealed amplification plate 4040 shown in FIG. 4F. The detectors 4260a, 4260b can have a thermal cycler used to amplify the target analytes within the sealed amplification plate 4040. The detectors 4260a, 4260b can detect the target analytes using a set of lighting fixtures, for example, LED lights. The analyzer 4000 can include a plate sealer 4220. The plate sealer 4220 can seal the amplification plate 4040. The analyzer 4000 can include a waste receptacle 4004 for disposing of the amplification plate 404. The analyzer 4000 can include a liquid waste repository that receives all of its liquid waste. The analyzer can include a multi-purpose robot 4300.

[0022] 4A and 4B depict the processing deck 4014. Detectors 4260a, 4260b associated with the processing deck 4014 are illustrated. A sample container shuttle transport assembly 4250 that can transport sample containers into the analyzer 4000 is also illustrated. The processing deck 4014 can include one or more consumable drawers 4120. In the illustrated embodiment, six consumable drawers 4120 are illustrated. The processing deck 4014 can include any number of drawers, including 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or any number consisting of two of these values. Each drawer 4120 includes a single consumable lane. Each drawer 4120 can include a pipette tip holder 4060. Each drawer 4120 can include an extraction vessel 4020. Each drawer 4120 can contain an amplification plate 4040. In the depicted embodiment, the processing deck 4014 includes six consumable drawer assemblies 4120. Each drawer 4120 can accommodate most of the consumables utilized in the assay workflow.

[0023] The processing deck 4014 may include a plate sealer 4220. The plate sealer 4220 may have a movable platform 4224 that receives and moves the amplification plate 4040 into the plate sealer 4220. The processing deck 4014 may include one or more orbital shakers 4230. The orbital shaker 4230 may vibrate the one or more sealed amplification plates 4040 in a circular motion to thoroughly rehydrate the dried reagents within the compartments of the sealed amplification plates 4040 with the eluted sample. The processing deck 4014 may include a reagent trough assembly 4050. The reagent trough assembly 4050 may include a trough that contains bulk reagents. The processing deck 4014 may include one or more piercing tools 4240. The piercing tools 4240 may be shaped to pierce the sturdy seals of the reagent trough assemblies 4050. The lancing tools 4240 fit toward the rear center of the processing deck 4014 within their respective nests or carriages 4270, 4280 until they are used to puncture a reagent trough assembly 4050. The processing deck 4014 may include one or more waste chutes 4210. The waste chutes 4210 may extend through the processing deck 4014. The waste chutes 4210 may receive used amplification plates 4040. The processing deck 4014 may include a tip drawer 4110. The tip drawer 4110 may house one or more pipette tip holders 4060. In the illustrated embodiment, the tip drawer 4110 may hold five pipette tip holders 4060.

[0024] 4C depicts a side perspective view of a drawer 4120. The drawer 4120 can include a housing 4122. The drawer 4120 can include a pipette tip station 4124. The drawer 4120 can include an extraction vessel station 4126. The drawer 4120 can include an amplification plate station 4128. The stations 4124, 4126, 4128 can be arranged linearly. The pipette tip station 4124 can be located near the front of the drawer 4120. The extraction vessel station 4126 can be located between the pipette tip station 4124 and the amplification plate station 4128. The amplification plate station 4128 can be located near the rear of the drawer 4120. The drawer 4120 can include other arrangements of the pipette tip station 4124, extraction vessel station 4126, and amplification plate station 4128. The pipette tip station 4124 can be configured to hold a pipette tip holder 4060. The extraction vessel station 4126 can be configured to hold an extraction vessel holder 4020. The amplification plate station 4128 can be configured to hold an amplification plate 4040. The drawer 4120 can be considered a one-lane drawer. The drawer 4120 can hold a single pipette tip holder 4060. The drawer 4120 can hold a single extraction vessel holder 4020. The drawer 4120 can hold a single amplification plate 4040.

[0025] The drawer 4120 can be configured to include an extractor module 4125. The extractor module 4125 can be disposed within a housing 4122 of the drawer 4120. The extractor module 4125 can include one or more magnets. The magnets can be mounted on a plate or platform of the extractor module 4125. The magnets can be mounted in a horizontal row. The magnets can be disposed on either side of an extraction vessel within the extraction vessel holder 4020. The extractor module 4125 can provide a movable magnetic field utilized to extract polynucleotides, such as DNA, from a sample. The extractor module 4125 can be housed in the consumable drawer 4120 beneath the extraction vessel station 4126. The extractor module 4125 can be selectively movable up and down along one or more rails 4127. The rails 4127 can be disposed on one or more side walls separating compartments beneath each of stations 4124, 4126, and 4128. The extractor module 4125 is in an upright or extracting position in Figure 4C. The extractor module 4125 can be lowered by movement along rails 4127.

[0026] The drawer 4120 can include a hinged retaining feature 4121. The retaining feature 4121 can rotate about a hinge 4123. The retaining feature 4121 can be a spring-loaded arm. The retaining feature 4121 can be hingedly connected to the housing 4122. The retaining feature 4121 can be connected directly behind the extraction vessel station 4126. The retaining feature 4121 can have a holding position and a consumable replacement position. In the holding position, the retaining feature 4121 extends across the pipette tip station 4124 and the extraction vessel station 4126, as shown in FIG. 4C . The retaining feature 4121 can include an opening that allows access to a pipette in the pipette tip holder 4060. The retaining feature 4121 can include an opening that allows access to an extraction vessel in the extraction vessel holder 4020. In this position, the retaining feature 4121 is configured to surround the periphery of the pipette tip holder 4060 positioned at the pipette tip station 4124. In this position, the retaining feature 4121 is configured to surround the periphery of the extraction vessel holder 4020 positioned at the extraction vessel station 4126. The retaining feature 4121 surrounds these peripheries while allowing access to these peripheries through openings in the retaining feature 4121. The retaining feature 4121 secures the edges of the pipette tip holder 4060. The retaining feature 4121 secures the edges of the extraction vessel holder 4020. The retaining feature 4121 limits or prevents the extraction vessel holder 4020 and the pipette tip holder 4060 from being inadvertently moved during operation. The retaining feature 4121 limits or prevents lift-up during a dispensing operation. When a consumable in the drawer 4120 needs to be replaced, the drawer 4120 can be extended from the front of the analyzer 4000. In some embodiments, a mechanism configured to lock the retention feature 4121 in a retaining position is released when the drawer 4120 is extended. Under the bias of a torsion spring positioned on the hinge 4123, the retention feature 4121 rotates about the hinge 4123 to a consumable replacement position, thereby providing clearance for a user to refill the drawer 4120 with consumables.

[0027] Referring back to FIG. 4A , the drawer 4120 fits into the front of the analyzer 4000. The drawer 4120 can be positioned between the detectors 4260a and 4260b. The drawer 4120 can include a visual indicator, such as a colored LED, at its front end to indicate the status of the drawer 4120 to a user. The visual indicator can notify a user that the drawer 4120 is currently in use. The visual indicator can notify a user that the drawer 4120 is ready for use. The visual indicator can notify a user that the drawer 4120 needs to be replenished with consumables.

[0028] 4D-4E illustrate an extraction vessel holder 4020. The extraction vessel holder 4020 can be a multi-layer structure. The extraction vessel holder 4020 can include a lower portion 4025 having a plurality of openings 4029. The lower portion 4025 can include one or more features 4028. The features 4028 on a sidewall 4027 of the lower portion 4025 can enable an interference fit with features on a drawer 4120 of the analyzer 4000. The extraction vessel holder 4020 can include multiple extraction vessels 4026. The extraction vessels 4026 can be connected through one or more foil strips 4023. The foil strips 4023 can be pierceable by a pipette tip prior to the addition of a sample. Each extraction vessel 4026 can contain ferric oxide ("FOX") for extracting polynucleotides, such as DNA, from a sample. The extraction vessel holder 4020 can include an upper portion 4022 having a plurality of openings 4021. The strips 4023 can be aligned within the openings 4021. The upper portion 4022 can include one or more ribs 4024. The ribs 4024 can extend transversely to the foil strips 4023 of the extraction vessels 4026. The ribs 4024 can provide structural strength to the extraction vessel holder 4020. The lower portion 4025 allows the extraction vessels 4026 to extend partially therethrough. The extraction vessels 4026 extend through the extraction vessel holder 4020 to enable processing by the extractor module 4125. A barcode can be positioned on the upper portion 4022 to aid in tracking information such as the lot, expiration date, and serial number of the contents of the extraction vessels 4026. The extraction vessel holder 4020 can be assembled with a sufficient number of extraction vessels 4026 for a single run. In the depicted embodiment, the brewing receptacle holder 4020 can accommodate 32 brewing receptacles 4026. The brewing receptacles 4026 can be arranged along four foil strips 4023. The brewing receptacles 4026 can be arranged in a grid.

[0029] The pipette tips are provided in a pipette tip holder 4060. The pipette tip holder 4060 can be configured to accommodate 96 pipette tips. The pipette tips can be arranged in a grid. In some embodiments of the analyzer 4000, four 1000 μL tips are used to process each sample. Additionally, a single reagent pipette tip can be used for each sample batch. The use of a single reagent pipette tip helps reduce the number of tips utilized because the reagent pipette tip does not come into direct contact with the sample.

[0030] FIG. 4F illustrates an amplification plate 4040. The amplification plate 4040 can include a plate body 4041. The plate body 4041 can include one or more engagement openings 4044a, 4044b extending into respective sides 4042a, 4042b thereof. The engagement openings 4044a, 4044b can allow a gripper of the multipurpose robot 4300 to engage the amplification plate assembly 4040 from both sides thereof. For example, opening 4044a extends through side 4042a and its opposite side. Further, opening 4044b extends through side 4042b and its opposite side. These openings allow the multipurpose robot 4300 to grasp and lift the amplification plate 4040 while it is in various orientations. The plate body 4041 can include multiple wells that define amplification compartments 4045. Compartments 4054 may contain dried reagents utilized in target amplification. Amplification plate 4040 may have a visual identifier, for example, a color code, for the reagents contained within its compartments 4045.

[0031] As each drawer 4120 is extended from the analyzer 4000, the user removes and replaces used amplification vessel holders 4020 and empty tip holders 4060. Additionally, the user can add unused amplification plates 4040 to the drawer 4120. Once the drawer 4120 is reinserted, the instrument 00 can check the inventory of that particular drawer 4120 to check for misloading. The instrument 00 can update the drawer 4120 to show it as ready for extraction.

[0032] Referring back to FIG. 4A , the processing deck 4014 also includes a tip drawer 4110. The tip drawer 4110 can be configured to hold one or more pipette tip holders 4060. The tip drawer 4110 can accommodate five pipette tip holders 4060. Each pipette tip holder 4060 can be a tip carriage with 96 wells. The tip drawer 4110 can be configured similarly to the drawer 4120 in that it includes a visual indicator on its front end. The pipette tip holders 4060 in the tip drawer 4110 can provide the pipette tips utilized for each sample extraction performed in the consumable drawer 4120, along with reagent tips and any spare tips that may be needed due to failed extraction or clogging. The tip drawer 4110 can be located to the left of the consumable drawer 4120.

[0033] These drawers 4110, 4120 are user accessible from the front of the analyzer 4000. Access to the drawers 4110, 4120 can be automated. The tip drawer 4110 can be locked or unlocked automatically by the analyzer 4000. The tip drawer 4110 can be locked or unlocked depending on its current status. The tip drawer 4110 can be locked or unlocked depending on the current status of the analyzer 4000. Each drawer 4120 can be locked or unlocked automatically by the analyzer 4000. Each drawer 4120 can be locked or unlocked depending on the current status of the drawer 4110. Each drawer 4120 can be locked or unlocked depending on the current status of the analyzer 4000. The tip drawer 4110 and one or more drawers 4120 can be locked or unlocked simultaneously. The tip drawer 4110 and one or more drawers 4120 can be locked or unlocked independently. The drawers 4110, 4120 can include a latching mechanism to lock them in a fully open position. The drawers 4110, 4120 can include a latching feature to lock them in a fully closed position. The drawers 4110, 4120 can include a latching mechanism to lock them in both the fully open and fully closed positions. The latching mechanism can be a push-to-close latch. The latching mechanism can be fully closed with a simple press or other action by the user. The latching mechanism can be spring-loaded. The latching mechanism can rigidly hold the drawers 4110, 4120 within the analyzer 4000. The latching mechanism can be built-in. The latching mechanism can include a trigger biased toward a locking configuration. The trigger can be depressed to unlock the drawer. The trigger can be depressed automatically by a module in the analyzer 400. The trigger can be depressed by the user. Drawer 4120 can be thought of as a single lane drawer.The drawer 4120 may include a latching mechanism to lock and unlock itself.

[0034] Referring back to FIG. 2 , the auxiliary deck 4012 is disposed adjacent to the bottom of the analyzer 4000 and is positioned directly below the processing deck 4014. The auxiliary deck 4012 houses electronic components and a waste repository. For example, the auxiliary deck 4012 can include a liquid waste repository 4002 that receives all liquid waste, such as from the extraction vessel 4026 during an extraction process and from the trough assembly 4050 during a content removal process. The auxiliary deck 4012 further includes one or more waste repositories 4004 that fit below each of the waste chutes 4210 that extend through the processing deck 4014, as shown in FIG. 4A . For example, a single waste repository 4004 can be positioned below the waste chute 4210, and this waste repository 4004 can collect all solid waste. In another example, two waste repositories 4004 can be used to collect used pipette tips and used amplification plates 4040, respectively. Each waste repository 4004 may contain sensing devices for detecting waste levels. The sensing devices may include, for example, optical sensors or ultrasonic sensors.

[0035] In the depicted embodiment, the processing deck 4014 includes six consumable drawer assemblies 4120. Each drawer assembly 4120 is a single-lane drawer. There are six drawers 4120 in total. In some cases, this drawer arrangement increases costs, and costs need to be reduced. In some cases, this drawer arrangement is complex to manufacture or operate, and the complexity in manufacture and operation needs to be reduced. For example, each drawer 4120 includes its own extractor module 4125. In another example, each drawer 4120 includes its own latching mechanism. There is a need to reduce the number of components, and therefore the costs, associated with the drawer assembly. The drawers described herein can include any of the features of the drawer 4120.

[0036] 5A-5C are diagrams of an embodiment of a two-lane drawer 4130 and corresponding extractor module 4135 in accordance with the present disclosure. The two-lane drawer 4130 can include any of the features of the drawer 4120. The two-lane drawer 4130 can include advantageous features. The two-lane drawer 4130 can be more cost-effective. The two-lane drawer 4130 can hold the same number of consumables as two drawers 4120. Advantageously, the two-lane drawer 4130 can have only one extractor module 4135. Advantageously, the two-lane drawer 4130 can have only one set of telescopic slides to facilitate its movement. Advantageously, the two-lane drawer 4130 can have only one indicator of its use. Advantageously, the two-lane drawer 4130 can have only one latching feature to prevent its withdrawal during use. Advantageously, the two-lane drawer 4130 can have only one retention feature for maintaining consumables therein. Referring back to FIG. 4A , the analyzer 4000 can contain six lanes of consumables using six drawers 4120, six corresponding extractor modules 4125, and six corresponding latching mechanisms. Using the two-lane drawer 4130, the same analyzer 4000 can hold six lanes of consumables using only three of the two-lane drawers 4130, three extractor modules 4135, and three corresponding latching mechanisms. The two-lane drawer 4130 can reduce part count. The two-lane drawer 4130 can reduce cost. The two-lane drawer 4130 can reduce complexity in manufacturing and operation. Because the number of consumables and, therefore, the number of samples processed are the same, the two-lane drawer 4130 does not affect overall throughput. The two-lane drawer 4130 does not affect customer exit time because the number of consumables and therefore the number of samples processed are the same.

[0037] The two-lane drawer 4130 is configured to accommodate most of the consumables utilized in the assay workflow. The two-lane drawer 4130 can include a pipette tip station 4134. The two-lane drawer 4130 can include an extraction vessel station 4136. The two-lane drawer 4130 can include an amplification plate station 4138. The pipette tip station 4134 is configured to hold two pipette tip holders 4060. The extraction vessel station 4136 is configured to hold two extraction vessel holders 4020. The amplification plate station 4138 is configured to hold two amplification plates 4040. The two-lane drawer 4130 can be configured to hold the same types of consumables described herein. The two-lane drawer 4130 can hold twice the number of consumables as the drawer 4120.

[0038] The stations 4134, 4136, 4138 can be arranged linearly. This arrangement can be front to back, with the pipette tip station 4134 at the front, the extraction vessel station 4136 in the middle, and the amplification plate station 4138 at the back. The two-lane drawer 4130 can hold two pipette tip holders 4060 side by side at the front. The two-lane drawer 4130 can hold two extraction vessel holders 4020 side by side in the middle. The two-lane drawer 4130 can hold two amplification plates 4040 side by side at the back.

[0039] This arrangement can allow the consumables to interact with other components of the analyzer 4000. The analyzer 4000 can include three two-lane drawers 4130. The two-lane drawer 4130 can fit between the two detectors 4260a and 4260b at the front of the analyzer 4000. An extraction vessel station 4136 can facilitate extraction of polynucleotides from a sample. The extraction vessel station 4136 can be positioned in relation to the extractor module 4135. Once extraction is complete, the extracted polynucleotides in the extraction vessel 4026 are used to rehydrate reagents, such as the main mixture reagent, in one of the amplification plates 4040 in the amplification plate station 4138. The amplification plate 4040 can be prepared for amplification, such as PCR. The prepared amplification plate 4040 can be moved to the appropriate reader 4260a, 4260b. This process can be accomplished through the use of a multi-function robot 4300, a plate sealer 4220, and an orbital mixer 4230. The two-lane drawer 4130 can include a visual indicator to indicate its current status.

[0040] The two-lane drawer 4130 houses an extractor module 4135 within a housing 4132. The two-lane drawer 4130 may include only one extractor module 4135. In some embodiments, the extractor module 4135 can process samples from two lanes simultaneously. In some embodiments, the extractor module 4135 can process samples from two extraction vessel holders 4020 simultaneously. In some embodiments, the extractor module 4135 can process twice as many samples as the extractor module 4125. The extractor module 4135 can move up and down relative to the two extraction vessel holders 4020 simultaneously. In some embodiments, the extractor module 4135 can process samples from the two lanes sequentially, for example, depending on when the samples were inserted into the extraction vessel 4026. In some embodiments, the extractor module 4135 can process samples from the two extraction vessel holders 4020 sequentially. In some embodiments, the extractor module 4135 can process samples from two lanes independently, for example, depending on when the samples were inserted into the extraction vessel 4026. In some embodiments, the extractor module 4135 can process samples from two extraction vessel holders 4020 independently. In some embodiments, the pipetting device extracts polynucleotides from only one of the extraction vessel holders 4020. In some embodiments, the workflow does not process samples from two extraction vessel holders 4020. The software can be limited to processing one extraction vessel holder 4020. The pipetting device can be limited to processing one extraction vessel holder 4020. The instrument can be limited to processing one extraction vessel holder 4020. The timing of the workflow can be limited to processing one extraction vessel holder 4020.

[0041] The extractor module 4135 includes a magnet 4136. The magnet 4136 can be positioned to apply a magnetic field to both sides of the extraction vessel. The magnet 4136 provides the magnetic field utilized to extract polynucleotides from the sample. The extractor module 4135 is vertically movable. The extractor module 4135 can move the magnet 4136, and therefore the corresponding magnetic field, relative to the extraction vessels 4026 of the two extraction vessel holders 4020 positioned in the extraction vessel station 4136. The extractor module 4135 can be positioned directly below the extraction vessel station 4136. The extractor module 4135 can be selectively movable up and down along one or more rails 4137. The rails 4137 can be located on a sidewall separating the extraction vessel station 4136 and the amplification plate station 4138. As shown in FIG. 5C , the extractor module 4135 is in an extended position. The magnet 4136 can be present near the extraction vessels 4026. The extractor module 4135 can be lowered below the extraction vessel 4026. The extractor module 4135 is housed in a two-lane drawer 4130. In some embodiments, the analyzer 4000 can include three two-lane drawers 4130 and three extractor modules 4135.

[0042] This movement of the magnets 4136 of the extractor module 4135 can facilitate sample processing. To aid in isolating the extracted polynucleotides from the sample, the polynucleotides can bind to ferric oxide ("FOX") particles positioned in the extraction vessels 4026. These particles allow for magnetic capture of the polynucleotides. This allows for isolation of the polynucleotides from the remaining unwanted sample, which can be washed away from the eluate using a wash buffer positioned in the trough assembly 4050. To perform this isolation, a magnetic field is applied to the extraction vessels 4026 of the two extraction vessel holders 4020. The magnetic field is applied by using the extractor module 4135. The extractor module 4135 includes magnets 4136 positioned to ensure that each row of extraction vessels 4026 is exposed to the magnetic field. In some embodiments, the magnets 4136 are positioned on either side of the extraction vessels 4026. The magnets 4136 are selectively moved from a position completely below the extraction vessels 4026 to a position adjacent to the extraction vessels 4026. In some embodiments, these magnets 4136 can lie in a generally plane. The extraction vessel 4026 can intersect this plane in extraction mode. The extraction vessel 4026 can reside completely below this plane in other modes. In some embodiments, the magnets 4136 overlap the extraction vessel 4026. The extractor module 4135 applies a magnetic field to the side of the extraction vessel 4026 that captures the bound polynucleotides.

[0043] The two-lane drawer 4130 can include a hinged retention feature 4131. The retention feature 4131 can be a spring-loaded plate. The retention feature 4131 can be hingedly connected to the housing 4132. The hinge 4133 of the retention feature 4131 can be located behind the extraction vessel station 4136. The hinge 4133 of the retention feature 4131 can be located in front of the amplification plate station 4138. The retention feature 4131 can have a retention position and a consumable replacement position. In the retention position, the retention feature 4131 extends across the pipette tip station 4134 and the extraction vessel station 4136, as shown in FIG. 5A . In this position, the retaining feature 4131 is configured to extend across at least a portion of the two pipette tip holders 4060 and the two extraction vessel holders 4020 positioned in the pipette tip station 4134 and the extraction vessel station 4136, respectively. The retaining feature 4131 can cover the peripheries of the two pipette tip holders 4060 and the peripheries of the two extraction vessel holders 4020, while allowing access to these peripheries through openings in the retaining feature 4131. The retaining feature 4131 acts as a cover to limit movement of the two extraction vessel holders 4020 and the two pipette tip holders 4060 during operations, such as a dispensing operation. The hinged retaining feature 4131 can include a locking feature to lock itself in a maintaining position.

[0044] When a consumable within the two-lane drawer 4130 needs to be removed and replaced with a new consumable, the two-lane drawer 4130 can be extended. A locking feature that locks the retention feature 4131 in a holding position can be released when the two-lane drawer 4130 is extended. The locking feature that locks the retention feature 4131 in a holding position can be a magnet. When the two-lane drawer 4130 is opened, the retention feature 4131 can be lifted. The retention feature 4131 is independent of the extension of the two-lane drawer 4130. Under the bias of the torsion spring, the retention feature 4131 can rotate about the hinge 4133 to a consumable replacement position. The consumable replacement position opens the retention feature 4131 to provide clearance for a user to refill consumables into the two-lane drawer 4130. The two-lane drawer 4130 can be extended along a telescoping slide. The two-lane drawer 4130 can include an assembly of extensions that slide or glide relative to one another. The slides can be metal. The slides can include ball bearings. The slides can be full-extension slides. The slides can extend in sections. The slides can extend in stages. The housing 4132 of the two-lane drawer 4130 can include tab and slot welds. The tab and slot arrangement can join one surface to another through slots.

[0045] The two-lane drawer 4130 can include a latching feature that locks the two-lane drawer 4130 to prevent extension of the two-lane drawer 4130 from the analyzer 4000. The two-lane drawer 4130 can include a latching feature that locks it in a fully open position. The two-lane drawer 4130 can include a latching feature that locks it in a fully closed position. The latching feature can be a push-to-close latch. In some embodiments, the latching feature does not lock in the open position. In some embodiments, the latching feature is not adapted to be locked in the open position. In some embodiments, the latching feature can be locked in the open position by a different telescoping slide. The latching feature can be fully closed by a simple press or other action by the user. The latching feature can be spring-loaded. The latching feature can rigidly hold the two-lane drawer 4130 in the analyzer 4000. The latching feature can be built-in. The latching feature may include a trigger biased toward a locking configuration. The trigger may be depressed to unlock the drawer. The trigger may be depressed automatically by a module in the analyzer 4000. The trigger may be depressed by a user. The two-lane drawer 4130 may include one latching mechanism for locking and unlocking itself.

[0046] The two-lane drawer 4130 can include a kick-out mechanism. The kick-out mechanism can facilitate sliding extension of the two-lane drawer 4130. The kick-out mechanism can extend along the bottom of the two-lane drawer 4130. The purpose of the kick-out mechanism can be to open the two-lane drawer 4130 at least a short distance to achieve easy access to the handle after the two-lane drawer 4130 is unlocked. The kick-out mechanism can open the two-lane drawer 4130 by 0.5", 1", 1.5", 2", 2.5", 3", 3.5", 4", at least 0.5", at least 1", at least 1.5", at least 2", at least 2.5", at least 3", at least 3.5", at least 4", or a number of inches between any two of these inch values. In some embodiments, the kick-out mechanism can open the two-lane drawer by at least 2 inches. The purpose of the kick-out mechanism can be to press the two-lane drawer 4130 against the latch when locked for repeatable positioning. In some embodiments, the kick-out mechanism cannot release the latch mechanism. In some embodiments, the user does not interact with the kick-out mechanism. The kick-out mechanism can allow the two-lane drawer 4130 to slide relative to the analyzer 4000.

[0047] 6A-6C are diagrams of a two-lane drawer 4130 associated with an analyzer 4000 in accordance with the present disclosure. FIG. 6A is an example of an analyzer 4000. The analyzer 4000 can include three two-lane drawers 4130. The two-lane drawers 4130 can house consumables as described herein. The analyzer 4000 can include a tip drawer 4110. The tip drawer 4110 can house a pipette tip holder 4060 as described herein.

[0048] 6B is a diagram of an analyzer 4000 that includes a structural frame 4011 configured to support and define various decks or levels for sample processing and analysis. The analyzer 4000 can include an auxiliary deck 4012, a processing deck 4014, and a multipurpose robotic deck 4016 as described herein. The analyzer 4000 can include a housing or shell that encloses internal components, as shown in FIG. 6A.

[0049] 6A-6C show an analyzer 4000 including three two-lane drawers 4130. The two-lane drawers 4130 can be adjacent. The two-lane drawers 4130 can slide or slide relative to a single drawer plate 4140. The drawer plate 4140 can remain stationary as the two-lane drawers 4130 are individually pulled out relative to the plate 4140. The two-lane drawers 4130 can extend relative to the drawer plate 4140. Each of the two-lane drawers 4130 can slide relative to the drawer plate 4140. Each of the two-lane drawers 4130 can include telescoping slides to allow them to slide relative to the drawer plate 4140. Each two-lane drawer 4130 can slide independently of the other two-lane drawers 4130. Each two-lane drawer 4130 can slide sequentially with the other two-lane drawer 4130. Each two-lane drawer 4130 can slide simultaneously with the other two-lane drawer 4130. Each two-lane drawer 4130 can include a latching mechanism. Each two-lane drawer 4130 can include a kick-out mechanism. Each two-lane drawer 4130 can include a retention feature 4131 that extends across the corresponding pipette tip station 4134 and extraction vessel station 4136. The two-lane drawers 4130 can be identical. The two-lane drawers 4130 can be stacked side by side. The two-lane drawers 4130 can include tab and slot welds.

[0050] FIG. 7 is a diagram of an embodiment of a two-lane drawer 4150 in accordance with the present disclosure. The two-lane drawer 4150 can include any of the features of the drawers described herein. The two-lane drawer 4150 can be used in combination with an extractor module 4135. The two-lane drawer 4150 can hold the same number of consumables as the two-lane drawer 4130. The two-lane drawer 4150 can hold the same number of consumables as two drawers 4120. The two-lane drawer 4150 has only one extractor module, like the drawer 4130. The two-lane drawer 4150 has only one latching feature, like the drawer 4130. This results in the ability to hold six lanes of consumables with only three extractors. This results in the ability to hold six lanes of consumables with only three latching features. The two-lane drawer 4150 can reduce part count. The two-lane drawer 4150 can reduce cost. The two-lane drawer 4150 can reduce manufacturing and operational complexity.

[0051] The two-lane drawer 4150 is configured to house most of the consumables utilized in the assay workflow. The two-lane drawer 4150 includes a pipette tip station 4154, an extraction vessel station 4156, and an amplification plate station 4158. The pipette tip station 4154 is configured to hold two pipette tip holders 4060. The extraction vessel station 4156 is configured to hold two extraction vessel holders 4020. The amplification plate station 4158 is configured to hold two amplification plates 4040.

[0052] The analyzer 4000 can include a stationary retaining housing 4161. In the depicted embodiment, the stationary retaining housing 4161 can be a cover positioned relative to the two-lane drawer 4150. The stationary retaining housing 4161 extends across the pipette tip station 4154 and the extraction vessel station 4156. In this position, the stationary retaining housing 4161 is configured to extend across at least a portion of the two pipette tip holders 4060 and at least a portion of the two extraction vessel holders 4020 positioned in the pipette tip station 4154 and the extraction vessel station 4156, respectively. The stationary retaining housing 4161 can cover the periphery of the two pipette tip holders 4060 and the two extraction vessel holders 4020, while allowing access thereto through openings in the stationary retaining housing 4161. The stationary retaining housing 4161 functions to limit movement of the extraction vessel holder 4020 and the pipette tip holder 4060 during operation. In some embodiments, the stationary retaining housing 4161 does not cover the amplification plate 4040 positioned in the amplification plate station 4158. The stationary retaining housing 4161 can be fixed relative to the drawer plate 4160. The two-lane drawer 4150 can be extended relative to the drawer plate 4160.

[0053] When a consumable in the drawer 4150 needs to be removed and replaced with a new consumable, the two-lane drawer 4150 is extended while the stationary retention housing 4161 remains stationary relative to the two-lane drawer 4150. The two-lane drawer 4150 slides relative to the stationary retention housing 4161. The two-lane drawer 4150 can include a latching feature. The two-lane drawer 4150 can include a kick-out mechanism. The two-lane drawer 4150 can extend along a telescoping slide. The stationary retention housing 4161 can include sheet metal with tab and slot welds.

[0054] FIG. 8 is a diagram of an embodiment of a three-lane drawer 4170 in accordance with the present disclosure. The three-lane drawer 4170 can include any feature of the drawers described herein. The three-lane drawer 4170 can be used in combination with an extractor module. The extractor module can move relative to the three lanes. In some embodiments, the extractor module can apply a magnetic field to three extraction vessel holders 4020. The three-lane drawer 4170 can hold the same number of consumables as three drawers 4120. The three-lane drawer 4170 can have only one extractor module. The three-lane drawer 4170 can have only one latching feature. This provides the ability to hold six lanes of consumables with only two extractors and two latching features. The three-lane drawer 4170 can reduce part count. The three-lane drawer 4170 can reduce cost. The three-lane drawer 4170 can reduce complexity in manufacturing and operation.

[0055] The three-lane drawer 4170 is configured to house most of the consumables utilized in the assay workflow. The three-lane drawer 4170 includes a pipette tip station 4174, an extraction vessel station 4176, and an amplification plate station 4178. The pipette tip station 4174 is configured to hold three pipette tip holders 4060. The extraction vessel station 4176 is configured to hold three extraction vessel holders 4020. The three extraction vessel holders 4020 can be positioned side-by-side. The amplification plate station 4178 is configured to hold three amplification plates 4040.

[0056] The analyzer 4000 can include a stationary retaining housing 4181. The stationary retaining housing 4181 can be a stationary cover positioned relative to the three-lane drawer 4170. The stationary retaining housing 4181 extends across the pipette tip station 4174 and the extraction vessel station 4176. In this position, the stationary retaining housing 4181 is configured to extend across at least a portion of the three pipette tip holders 4060 and at least a portion of the three extraction vessel holders 4020 positioned in the pipette tip station 4174 and the extraction vessel station 4176, respectively. The stationary retaining housing 4181 can cover the peripheries of the pipette tip holders 4060 and the peripheries of the extraction vessel holders 4020, while allowing access to these peripheries through openings in the stationary retaining housing 4181. The stationary retaining housing 4181 functions to limit movement of the extraction vessel holder 4020 and the pipette tip holder 4060 during operation. In some embodiments, the stationary retaining housing 4181 does not cover the amplification plate 4040 positioned in the amplification plate station 4178.

[0057] When a consumable in the three-lane drawer 4170 needs to be removed and replaced with a new consumable, the stationary retention housing 4181 remains stationary relative to the three-lane drawer 4170 while the three-lane drawer 4170 is extended. The three-lane drawer 4170 can include a latching feature. The three-lane drawer 4170 can include a kick-out mechanism. The three-lane drawer 4170 can extend along a telescoping slide. The stationary retention housing 4181 can include sheet metal with tab and slot welds.

[0058] 9A-9B are diagrams of an embodiment of a six-lane drawer 4190 in accordance with the present disclosure. The six-lane drawer 4190 can be used in combination with a tip drawer 4110. The tip drawer 4110 can be configured to hold multiple pipette tip holders 4060. The tip drawer 4110 can accommodate five pipette tip holders 4060. The six-lane drawer 4190 and the tip drawer 4110 can be positioned side-by-side. In some embodiments, the six-lane drawer 4190 and the tip drawer 4110 can be a single unit. The six-lane drawer 4190 and the tip drawer 4110 can move together to extend from the analyzer 4000.

[0059] The six-lane drawer 4190 can include any of the features of the drawers described herein. The six-lane drawer 4190 can be used in combination with an extractor module. The extractor module can move relative to the six lanes. The extractor module can apply a magnetic field to one extraction vessel holder 4020. The extractor module can apply a magnetic field to two or three extraction vessel holders 4020. The extractor module can apply a magnetic field to six extraction vessel holders 4020. The extractor module can move along an axis relative to the six-lane drawer 4190. The extractor module can include a slide 4270. The slide 4270 can be a rail along which the extractor module slides. The slide 4270 is described in more detail below with reference to FIG. 10A. The six extraction vessel holders 4020 can be positioned side-by-side. The six-lane drawer 4190 can hold the same number of consumables as the six drawers 4120. The six-lane drawer 4190 can have only one extractor module. The six-lane drawer 4190 can have only one latching feature. This results in the ability to hold six lanes of consumables with only one extractor module and one latching feature. The six-lane drawer 4190 can reduce part count. The six-lane drawer 4190 can reduce cost. The six-lane drawer 4190 can reduce complexity in manufacturing and operation.

[0060] The six-lane drawer 4190 is configured to house most of the consumables utilized in the assay workflow. The six-lane drawer 4190 includes a pipette tip station 4194, an extraction vessel station 4196, and an amplification plate station 4198. The pipette tip station 4194 is configured to hold six pipette tip holders 4060. The extraction vessel station 4196 is configured to hold six extraction vessel holders 4020. The amplification plate station 4198 is configured to hold six amplification plates 4040.

[0061] The analyzer 4000 can include a stationary retaining housing 4115. The stationary retaining housing 4115 can be a single unitary structure extending over the tip drawer 4110, at least a portion of the pipette tip station 4191, and at least a portion of the extraction vessel station 4196. The stationary retaining housing 4115 can be a stationary cover positioned relative to the tip drawer 4110. The stationary retaining housing 4115 can be a stationary cover positioned relative to the six-lane drawer 4190. The stationary retaining housing 4115 can extend over the pipette tip station 4194 and the extraction vessel station 4196. In this position, the stationary retaining housing 4115 is configured to extend over at least a portion of the six pipette tip holders 4060 positioned in the pipette tip station 4194 of the six-lane drawer 4190. In this position, the stationary retaining housing 4115 is configured to extend over at least a portion of the five pipette tip holders 4060 of the tip drawer 4110. In this position, the stationary retaining housing 4115 is configured to extend over at least a portion of the six extraction vessel holders 4020, each positioned in the extraction vessel station 4196. The stationary retaining housing 4115 can be a single, unitary structure that maintains the consumables within the tip drawer 4110 and the six-lane drawer 4190.

[0062] The stationary retaining housing 4115 can cover the perimeter of the pipette tip holder 4060 and the perimeter of the extraction vessel holder 4020, while allowing access to these perimeters through openings in the stationary retaining housing 4115. The stationary retaining housing 4115 functions to limit movement of the extraction vessel holder 4020 and the pipette tip holder 4060 during operation. In some embodiments, the stationary retaining housing 4115 does not cover the amplification plate 4040 positioned in the amplification plate station 4198. The stationary retaining housing 4115 can include a section for the tip drawer 4110. The stationary retaining housing 4115 can include sheet metal with tab and slot welds. The stationary retaining housing 4115 can include a separate top plate attached to the outside of a support. The stationary retaining housing 4115 can include supports attached to the sides of the base 4116. The stationary retaining housing 4115 can include vertical supports to resist distortion.

[0063] When a consumable in the six-lane drawer 4190 needs to be removed and replaced with a new consumable, the stationary retention housing mechanism 4115 remains stationary relative to the six-lane drawer 4190 while the six-lane drawer 4190 is extended. The six-lane drawer 4190 can include a latching feature. The six-lane drawer 4190 can include a kick-out mechanism. The six-lane drawer 4190 can extend along a telescoping slide. In some embodiments, each lane of the six-lane drawer 4190 slides together. The six-lane drawer 4190 can include a single drawer front. In an alternative embodiment not illustrated, each lane of the six-lane drawer 4190 can slide individually when associated with a respective one of multiple drawer fronts. Each lane can include an individual sliding sub-drawer. The six-lane drawer 4190 can be associated with an extractor having any of the mechanisms described herein. In some embodiments, the extractor can move upward when processing is performed on the lane and lock the lane so that it cannot be opened.

[0064] 10A-10C are diagrams of an extractor module 4200 according to the present disclosure. The extractor module 4200 can be used with any of the drawers described herein. The extractor module 4200 can include a scissor lift design. The scissor lift can include a platform or plate 4202. The plate 4202 can be coupled to multiple magnets 4204. The magnets 4204 can apply a magnetic field to the extraction vessels 4026 of the extraction vessel holders 4020 as described herein. The plate 4202 can include magnets 4204 configured to apply a magnetic field to the extraction vessels 4026 positioned in a single lane. The plate 4202 can include a magnet configured to apply a magnetic field to a single extraction vessel holder 4020. The scissor lift can include a base 4206. The base 4206 and the plate 4202 can be structures having the same or similar shapes. The base 4206 and the plate 4202 can have a mirror image configuration. The scissor lift can move vertically. The scissor lift can include scissor legs 4208. The scissor legs 4208 are crisscross struts that bridge the gap between the base 4206 and the plate 4202. One of the scissor legs 4208 is fixed to the plate 4202 and movable relative to the base 4206. The other scissor leg 4208 is fixed to the base 4206 and movable relative to the plate 4202. The scissor lift moves upward by extending the scissor legs 4208 from a substantially horizontal orientation to a substantially vertical orientation. The scissor lift moves downward by extending the scissor legs 4208 from a substantially vertical orientation to a substantially horizontal orientation. The extractor module 4200 can include a slide 4270. The slide 4270 can allow the extractor module 4200 to move relative to a corresponding drawer. The extractor module 4200 can include a linear drive 4272. The linear drive 4272 can move the extractor module 4200 relative to the slide 4270 .

[0065] FIG. 10B shows an extractor module 4200 relative to a two-lane drawer 4130. FIG. 10B illustrates three two-lane drawers 4130. The extractor module 4200 can be used with any of the drawers described herein. The extractor module 4200 can be used with a three-lane drawer 4170. The extractor module 4200 can be used with a six-lane drawer 4190. The two-lane drawer 4130 can include an extraction vessel station 4136. The extraction vessel station 4136 can hold two extraction vessel holders 4020. The extraction vessel holders 4020 can be side-by-side. The extractor module 4200 can apply a magnetic field to a first extraction vessel holder 4020 of a first two-lane drawer 4130 in a first position, as shown in FIG. 10B. The extractor module 4200 can move up and down relative to the first extraction vessel holder 4020 at a first position. The extractor module 4200 can apply a magnetic field to a single extraction vessel holder 4020 in the extraction vessel station 4136 of the first two-lane drawer 4130. The extractor module 4200 can move from the first position to a second position. The extractor module 4200 can apply a magnetic field to the second extraction vessel holder 4020 of the first two-lane drawer 4130 at the second position. The extractor module 4200 can move along a slide 4270 to the second extraction vessel holder 4020. The extractor module 4200 can move up and down relative to the second extraction vessel holder 4020 at the second position.

[0066] The extractor module 4200 can move along a slide 4270 to the second two-lane drawer 4130. The extractor module 4200 can move from a second position to a third position. At the third position, the extractor module 4200 can apply a magnetic field to the third extraction vessel holder 4020 of the second two-lane drawer 4130. The extractor module 4200 can move along a slide 4270 to the third extraction vessel holder 4020. At the third position, the extractor module 4200 can move up and down relative to the third extraction vessel holder 4020. The extractor module 4200 can move from the third position to a fourth position. At the fourth position, the extractor module 4200 can apply a magnetic field to the fourth extraction vessel holder 4020 of the second two-lane drawer 4130. The extractor module 4200 can move along a slide 4270 to the fourth extraction vessel holder 4020. The extractor module 4200 can move up and down relative to the fourth extraction vessel holder 4020 in the fourth position.

[0067] The extractor module 4200 can move along a slide 4270 to the third two-lane drawer 4130. The extractor module 4200 can move from a fourth position to a fifth position. At the fifth position, the extractor module 4200 can apply a magnetic field to the fifth extraction vessel holder 4020 of the third two-lane drawer 4130. The extractor module 4200 can move along a slide 4270 to the fifth extraction vessel holder 4020. At the fifth position, the extractor module 4200 can move up and down relative to the fifth extraction vessel holder 4020. The extractor module 4200 can move from the fifth position to a sixth position. At the sixth position, the extractor module 4200 can apply a magnetic field to the sixth extraction vessel holder 4020 of the third two-lane drawer 4130. The extractor module 4200 can move along a slide 4270 to the sixth extraction receptacle holder 4020. The extractor module 4200 can move up and down relative to the sixth extraction receptacle holder 4020 at the sixth position. The extractor module 4200 can move from the sixth position to the first position and back, and can move between any two of the first position, second position, third position, fourth position, fifth position, or sixth position. Although the extractor module 4200 is shown with respect to three two-lane drawers 4130, the extractor module 4200 can be used with any of the drawers described herein.

[0068] FIG. 10A illustrates the extractor module 4200 in an extended or upward configuration. FIG. 10C illustrates the extractor module 4200 in a folded or downward configuration. The extractor module 4200 can move up and down to change the position of the magnetic field relative to the extraction vessel 4026 of the extraction vessel holder 4020. The assembly can include three two-lane drawers 4130. The two-lane drawers 4130 can be positioned side-by-side. In some embodiments, each two-lane drawer 4130 can include an extractor module 4200. The assembly can include three extractor modules 4200. The extractor module 4200 can be moved between lanes of the two-lane drawer 4130. In some embodiments, the assembly can include one extractor module 4200. The extractor module 4200 can be moved between all two-lane drawers 4130. The extractor module 4200 can be moved between three two-lane drawers 4130. The extractor module 4200 can be moved between all six lanes. In some uses, the extractor module 4200 can apply a magnetic field to the extraction vessel holders 4020 in a first two-lane drawer 4130 and then fold out from the first two-lane drawer 4130. The extractor module 4200 can then move to a second two-lane drawer 4130, then extend to apply a magnetic field to the extraction vessel holders 4020 in the second two-lane drawer 4130, and then fold out from the second two-lane drawer 4130. Furthermore, the extractor module 4200 can move to a third two-lane drawer 4130, then extend to apply a magnetic field to the extraction vessel holders 4020 in the third two-lane drawer 4130, and then fold out from the third two-lane drawer 4130. The extractor modules 4200 can be moved to any two-lane drawer 4130 in any order.

[0069] FIG. 11 is a diagram of an extractor module 4300 according to the present disclosure. The extractor module 4300 can be used with any of the drawers described herein. The extractor module 4300 can include a pusher design. The pusher can include a platform or plate 4302. The plate 4302 can be coupled to a plurality of magnets 4304. The plate 4302 can include a magnet 4304. The magnet 4304 applies a magnetic field to the extraction vessel 4020. The magnet 4304 can be positioned to apply a magnetic field to two lanes. The magnet 4304 can be positioned to apply a magnetic field to two extraction vessel holders 4020. In some embodiments, the plate 4302 with magnets 4304 can remain in the two-lane drawer 4130 at all times. In some embodiments, there can be one plate 4302 with magnets 4304 in each two-lane drawer 4130. The extractor module 4300 can include a pusher arm 4308. The pusher arm 4308 rotates counterclockwise when viewed in FIG. 11 to move the plate 4302 upward, and rotates clockwise when viewed in FIG. 11 to move the plate 4302 downward. The drawer 4130 can include a plate 4310 having a slot 4312 through which the pusher arm 4308 rotates. The extractor module 4300 can include a slide 4370. The slide 4370 can allow the extractor module 4300 to move relative to the corresponding drawer. The extractor module 4300 can include a linear drive 4372. The linear drive 4372 can move the extractor module 4300 relative to the slide 4370. In some embodiments, the magnet 4304 is not directly attached to the linear drive 4372 or the pusher arm 4308.

[0070] 11 illustrates the extractor module 4300 relative to a two-lane drawer 4130. The two-lane drawer 4130 includes a pipette tip station 4134, an extraction vessel station 4136, and an amplification plate station 4138. The pipette tip station 4134 is configured to hold two pipette tip holders 4060. The extraction vessel station 4136 is configured to hold two extraction vessel holders 4020. The amplification plate station 4138 is configured to hold two amplification plates 4040. The extraction vessels 4020 can be side-by-side. The extractor module 4300 can apply a magnetic field to the first extraction vessel holder 4020 and the second extraction vessel holder 4020 in an upward position. The extractor module 4300 can move up and down relative to the extraction vessel holders 4020. The extractor module 4300 can apply a magnetic field to two extraction vessel holders 4020 in the extraction vessel station 4136 .

[0071] Referring back to FIG. 6C , the assembly can include three two-lane drawers 4130. The two-lane drawers 4130 can be positioned side-by-side. The extractor module 4300 can be folded out from the first two-lane drawer 4130. The extractor module 4300 can be moved to the second two-lane drawer 4130. The extractor module 4300 can be moved along a slide 4370 to the second two-lane drawer 4130. The extractor module 4200 can apply a magnetic field to the extraction vessel holder 4020 of the second two-lane drawer 4130 in the second position. The extractor module 4300 can be moved up and down relative to the second two-lane drawer 4130 in the second position. The extractor module 4300 can be folded out from the second two-lane drawer 4130. The extractor module 4300 can be moved to the third two-lane drawer 4130. The extractor module 4300 can move along a slide 4370 to the third two-lane drawer 4130. The extractor module 4200 can apply a magnetic field to the extraction vessel holder 4020 of the third two-lane drawer 4130 in the third position. The extractor module 4300 can move up and down relative to the third two-lane drawer 4130 in the third position. Although the extractor module 4300 is shown with respect to the two-lane drawer 4130, the extractor module 4300 can be used with any of the drawers described herein. The extractor module 4300 can be moved between drawers. The extractor module 4300 can reduce the total number of extractor modules required for a multiple drawer assembly of the analyzer 4000. The extractor module 4300 can reduce cost. The extractor module 4300 can reduce complexity in manufacturing and operation. This can allow for one extractor module 4300 to be present in the analyzer 4000.

[0072] In some embodiments, a two-lane drawer assembly is provided. The two-lane drawer assembly can include a two-lane drawer. The two-lane drawer can include a pipette tip station configured to accommodate two pipette tip holders. The two-lane drawer can include an extraction vessel station configured to accommodate two extraction vessel holders. The two-lane drawer can include an amplification plate station configured to accommodate two amplification plates. The two-lane drawer assembly can include an extractor module positioned relative to the extraction vessel station. In some embodiments, the extractor module includes a magnet configured to apply a magnetic field to the extraction vessel holders of the two extraction vessel holders.

[0073] In some embodiments, the extractor module is configured to process samples from one extraction vessel holder. In some embodiments, the extractor module is configured to move up and down relative to the two extraction vessel holders. In some embodiments, the extractor module is configured to move up and down along one or more rails. In some embodiments, the two-lane drawer includes a retention feature configured to extend over a portion of the pipette tip station and the extraction vessel station. In some embodiments, the two-lane drawer includes a latching mechanism including a push-to-close latch. In some embodiments, the two-lane drawer includes a kick-out mechanism configured to facilitate sliding extension of the two-lane drawer. In some embodiments, the two-lane drawer includes a telescoping slide. In some embodiments, the two-lane drawer assembly can include two pipette tip holders, two extraction vessel holders, and two amplification plates. In some embodiments, the two-lane drawer assembly can include three two-lane drawers. In some embodiments, the two-lane drawer assembly can include a tip drawer configured to accommodate five pipette tip holders.

[0074] The foregoing description is intended to illustrate various aspects of the present technology. The examples presented herein are not intended to limit the scope of the present technology. While the present technology has now been fully described, it will be apparent to those skilled in the art that many variations and modifications can be made thereto without departing from the spirit and scope of the appended claims. [Explanation of symbols]

[0075] 00 High-throughput system 10 Pre-analytical Systems 1332 Overall system display interface 2000 First Analyzer 4000 Secondary Analyzer

Claims

1. 1. A two-lane drawer assembly comprising: a two-lane drawer including a pipette tip station configured to accommodate two pipette tip holders, an extraction vessel station configured to accommodate two extraction vessel holders, and an amplification plate station configured to accommodate two amplification plates; an extractor module positioned relative to the extraction vessel station, the extractor module including a magnet configured to apply a magnetic field to the extraction vessel holders of the two extraction vessel holders; 2. A two-lane drawer assembly comprising:

2. 10. The two-lane drawer assembly of claim 1, wherein the extractor module is configured to process samples from one of the extraction vessel holders.

3. The two-lane drawer assembly of claim 1 , wherein the extractor module is configured to move up and down relative to the two extraction vessel holders.

4. The two-lane drawer assembly of claim 1 , wherein the extractor module is configured to move up and down along one or more rails.

5. The two-lane drawer assembly of claim 1 , wherein the two-lane drawer includes a retention feature configured to extend over a portion of the pipette tip station and the extraction vessel station.

6. The two-lane drawer assembly of claim 1 , wherein the two-lane drawer includes a latching mechanism including a push-to-close latch.

7. The two-lane drawer assembly of claim 1 , wherein the two-lane drawer includes a kick-out mechanism configured to facilitate sliding extension of the two-lane drawer.

8. The two-lane drawer assembly of claim 1 , wherein the two-lane drawer includes telescoping slides.

9. 2. The two-lane drawer assembly of claim 1, further comprising the two pipette tip holders, the two extraction vessel holders, and the two amplification plates.

10. The two-lane drawer assembly of claim 1 further comprising three of said two-lane drawers.

11. The two-lane drawer assembly of claim 1 further comprising a tip drawer configured to accommodate five pipette tip holders.

Images