Medication dispensing devices

Abstract

This invention provides a novel drug delivery device that utilizes microneedles to enable continuous administration of drug solutions into the body. [Solution] A drug dispensing device comprising: a cylindrical injection part for puncturing the skin and injecting a drug solution into a living body; and a guide part having a through hole into which the injection part is inserted and which guides the sliding direction of the injection part in the through hole, wherein the injection part has a cylindrical sliding part in which a flow channel for the drug solution is formed therein, and a microneedle provided at the end of the sliding part and communicating with the flow channel, and the guide part has a guide part body having a through hole, an elastic body provided on one end of the through hole in the guide part body, and an adhesive layer provided on the surface of the elastic body, wherein at least one of the injection part and the guide part has a first holding structure that holds the injection part in a first position in which the tip of the microneedle protrudes beyond the adhesive layer.

Description

Technical Field

[0001] The present invention relates to a dosing device.

Background Art

[0002] Conventionally, a device for continuously administering a chemical solution into a living body has been known. In such a device, a hollow puncture needle is inserted into the skin to inject the chemical solution into the body, and this configuration is known.

[0003] The inventors have proposed a dosing device having a fine needle called a "microneedle" as a minimally invasive medical device alternative to the above configuration (see, for example, Patent Documents 1 and 2). A microneedle is a needle with a diameter and length of less than 1 mm (on the order of μm). [[ID=1"]]

Prior Art Documents

Patent Documents

[0004] [[ID=]5]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in the configurations of Patent Documents 1 and 2, it is necessary to continue dosing while sandwiching and fixing the skin of the subject using the dosing device. Therefore, the usability is poor, and there is a risk that the device will come off during continuous use for a long period of time.

[0006] The present invention has been made in view of such circumstances, and an object thereof is to provide a novel dosing device that employs a microneedle and can continuously administer a chemical solution into a living body.

Means for Solving the Problems

[0007] To solve the above problems, one aspect of the present invention includes the following aspects.

[0008] [1] A drug dispensing device comprising: a cylindrical injection part for puncturing the skin and injecting a drug solution into a living body; and a guide part having a through hole into which the injection part is inserted and which guides the sliding direction of the injection part in the through hole, wherein the injection part comprises a cylindrical sliding part in which a flow channel for the drug solution is formed therein, and a microneedle provided at the end of the sliding part and communicating with the flow channel, wherein the guide part comprises a guide part body having the through hole, an elastic body provided on one end of the guide part body on the side of the through hole, and an adhesive layer provided on the surface of the elastic body, wherein at least one of the injection part and the guide part has a first holding structure that holds the injection part in a first position in which the tip of the microneedle protrudes beyond the adhesive layer.

[0009] [2] The drug dispensing device according to [1], having a second holding structure that holds the injection portion in a second position in which the tip of the microneedle is housed in the through hole.

[0010] [3] The drug dispensing device according to [2], wherein the second holding structure is an elastic member provided between the injection portion and the guide portion and holds the injection portion in the second position.

[0011] [4] The elastic body surrounds the through hole and is a drug dispensing device according to any one of [1] to [3].

[0012] [5] The medication dispensing device according to [4], wherein the elastic body is a closed annular shape in plan view.

[0013] [6] The medication dispensing device according to [4] or [5], wherein the elastic body is thicker on the outer circumference than on the inner circumference.

[0014] [7] The medication dispensing device according to any one of [1] to [6], wherein the guide body has a recess on one end side into which the elastic body fits.

[0015] [8] The drug delivery device according to any one of [1] to [7], wherein the elastic body is replaceable.

[0016] [9] The drug delivery device according to [8], having, as a replaceable part of the elastic body, a second elastic body having an elastic modulus different from that of the elastic body.

[0017]

[10] The sliding part has a cylindrical sliding part main body in which a part of the flow path is formed, and a flow path member that communicates with a part of the flow path of the sliding part main body and can be connected to an external device for injecting the drug solution into the drug delivery device. The drug delivery device according to any one of [1] to [9], wherein the flow path member is detachable from the sliding part main body.

[0018]

[11] The drug delivery device according to

[10] , having, as a replaceable part of the flow path member, a second flow path member that can be connected to a second external device.

Advantages of the Invention

[0019] According to the present invention, it is possible to provide a novel drug delivery device that employs a micro needle and can continuously administer a drug solution into a living body.

Brief Description of the Drawings

[0020] [Figure 1] FIG. 1 is a schematic perspective view showing the drug delivery device 1 of the embodiment. [Figure 2] FIG. 2 is an exploded perspective view of the drug delivery device 1. [Figure 3] FIG. 3 is a schematic perspective view of the sliding part 11 (sliding part main body 12) of the drug delivery device 1. [Figure 4] FIG. 4 is an explanatory diagram for explaining the operation of the drug delivery device 1. [Figure 5] FIG. 5 is an explanatory diagram for explaining the operation of the drug delivery device 1. [Figure 6] FIG. 6 is an explanatory diagram for explaining the operation of the drug delivery device 1.

Embodiments for Carrying Out the Invention

[0021] The medication dispensing device according to this embodiment will be described below with reference to Figures 1 to 6. Note that in all the following drawings, the dimensions and proportions of each component have been appropriately altered for clarity.

[0022] [Medication dispensing equipment] Figure 1 is a schematic perspective view showing the medication dispensing device 1 of this embodiment. Figure 2 is an exploded perspective view of the medication dispensing device 1. Figure 3 is a schematic perspective view of the sliding part 11 (sliding part body 12) of the medication dispensing device 1.

[0023] As shown in Figures 1-3, the drug dispensing device 1 comprises an injection section 10 and a guide section 20. A portion of the injection section 10 is inserted into a through-hole 20x in the guide section 20. In its pre-use state, the injection section 10 is supported by a compression spring (elastic member) 30. The drug dispensing device 1 is used by being attached to the skin of a living body and is used to continuously administer a drug solution L supplied from an external device 50 into the living body.

[0024] In this specification, when the dispensing device 1 is placed with the guide portion 20 on the ground, the direction normal to the ground surface of the guide portion 20 is defined as the vertical direction of the dispensing device 1, and the injection portion 10 side of the dispensing device 1 is referred to as the "upper" side, and the guide portion 20 side as the "lower" side. Other expressions of "upper" and "lower" also refer to relative positions defined based on the same vertical direction.

[0025] Furthermore, in this specification, "plan view" refers to the field of view when the medication dispensing device 1 is viewed from above in the vertical direction.

[0026] <Injection part> The injection unit 10 is a cylindrical member that is inserted into the skin to inject the drug solution L into the body. The injection unit 10 has a sliding part 11 and a puncture part 15 having a microneedle 152.

[0027] (Sliding part) The sliding part 11 is a cylindrical member in which a flow path 10x through which the chemical solution L flows is formed. The sliding part 11 has a sliding part body 12 and a flow path member 13.

[0028] (Sliding part body) The sliding part body 12 is a cylindrical member in which a portion of the flow path 10x of the sliding part 11 is formed.

[0029] The sliding part body 12 has a through hole 12x that forms part of the flow path 10x. The through hole 12x penetrates the sliding part body 12 in the vertical direction. The through hole 12x is formed by connecting a first hole 12a from the top, a second hole 12b which is smaller in diameter than the first hole 12a, a third hole 12c which is larger in diameter than the second hole 12b, and a fourth hole 12d which has a tapered surface with an opening diameter that gradually increases downwards.

[0030] Due to the change in inner diameter, an inner upper surface 12e is formed at the connection point between the first hole 12a and the second hole 12b. In addition, an inner lower surface 12f is formed at the connection point between the second hole 12b and the third hole 12c of the sliding part body 12.

[0031] An O-ring 14 is inserted into the through hole 12x from above. The O-ring 14 is positioned on the inner upper surface 12e.

[0032] The sliding part body 12 has a cylindrical first member 121 and a second member 122 provided at the upper end of the first member 121.

[0033] The outer surface of the first member 121 has a pair of planar portions 121x extending in the vertical direction and curved portions 121y which are part of a cylindrical surface and are continuous with the pair of planar portions 121x. The pair of planar portions 121x are arranged, for example, parallel to each other.

[0034] Each of the pair of flat sections 121x is provided with a substantially elliptical convex section 121z.

[0035] The second member 122 is an annular structure (flange) in plan view, provided above the first member 121. The second member 122 is provided radially and has a groove 12y that connects to the through hole 12x.

[0036] (Flow channel member) The flow path member 13 communicates with the through hole 12x (part of the flow path) of the sliding body 12 and is a member that can be connected to an external device 50 that supplies the drug solution L to the drug dispensing device 1. As the external device 50, for example, a small pump having a reservoir tank for storing the drug solution L can be used.

[0037] The flow channel member 13 has a through hole 13x that forms part of the flow channel 10x. The flow channel member 13 is connected in the following order: a first pipe 13a extending along the groove 12y of the sliding body 12, a bent section 13b with a larger outer diameter than the first pipe 13a and bent at approximately 90°, a flange 13c, a second pipe 13d extending in the vertical direction, and a connecting section 13e. One end of the through hole 13x opens into the first pipe 13a, and the other end opens into the connecting section 13e.

[0038] The flow path member 13 is connected to the sliding part body 12 by inserting the connecting portion 13e into the second hole 12b of the sliding part body 12. The connecting portion 13e is a structure formed in the shape of a frustoconical cone, with its outer diameter gradually decreasing downwards, and has an upper surface 13g at the connection point with the second pipe 13d. When the flow path member 13 is inserted into the sliding part body 12, the connecting portion 112e is locked to the inner lower surface 12f at the upper surface 13g.

[0039] Furthermore, when the flow path member 13 has its connecting portion 13e inserted into the second hole 12b, an O-ring 14 is sandwiched between the lower surface 13f of the flange 13c and the inner upper surface 12e of the sliding portion body 12. This suppresses liquid leakage at the connection point between the sliding portion body 12 and the flow path member 13.

[0040] The flow path member 13 is detachable from the sliding body 12. The flow path member 13, which is configured to be detachable from the sliding body 12, may be interchangeable with other flow path members. In this case, the interchangeable flow path member may be the same as or different from the flow path member 13. It is preferable that the flow path member different from the flow path member 13 (second flow path member) is configured to be connectable to, for example, an external device different from the external device 50 described above (second external device). In this way, by making the flow path member interchangeable depending on the external device used, it is possible to connect to various external devices and administer the drug solution L. A syringe can be exemplified as the second external device.

[0041] (Puncture site) The puncture portion 15 is provided at the end of the sliding portion 11 (the lower end 12g of the sliding portion body 12). The puncture portion 15 has a disc-shaped base portion 151 and a plurality of microneedles 152 extending downward from the lower surface 151a of the base portion 151.

[0042] The base 151 is a disc-shaped member with microneedles 152 provided on one side. The base 151 is connected to the lower end 12g of the sliding body 12 with the microneedles 152 facing downwards. The connection between the sliding body 12 and the base 151 is liquid-tight, preventing leakage of the liquid chemical L flowing inside.

[0043] The microneedle 152 has a through hole that communicates with the flow path 10x. More specifically, the puncture portion 15 has a through hole that penetrates the base portion 151 and the microneedle 152, and communicates with the flow path 10x. The drug dispensing device 1 of this embodiment has four microneedles 152. The number of microneedles 152 may be less than four or more than four, as long as it does not hinder the effect of the invention.

[0044] In the puncture portion 15, the base portion 151 and the microneedle 152 are integrally molded. The material of the puncture portion 15 can be, for example, a biodegradable plastic. An example of a biodegradable plastic is polyglycolic acid (PGA).

[0045] The above-mentioned biodegradable plastics are known to degrade easily under humid heat conditions. Therefore, when the puncture site 15 is made of biodegradable plastic, electron beam sterilization is desirable as a sterilization method for the injection site 10 or the sliding part 11. From this viewpoint, when the puncture site 15 is made of biodegradable plastic, it is desirable that the material for the injection site 10 or the sliding part 11 is also electron beam sterilizable and has sufficient strength. Polystyrene is suitable as such a resin.

[0046] <Guide Section> The guide portion 20 has a through hole 20x into which the injection portion 10 is inserted, and guides the sliding direction of the injection portion 10 within the through hole 20x. The guide portion 20 comprises a guide portion body 21, an elastic body 22, and an adhesive layer 23. The through hole 20x extends in the direction normal to the lower surface of the adhesive layer 23 (the contact surface of the guide portion 20) (vertical direction).

[0047] (Guide section body) The guide body 21 is a cylindrical member having a through hole 21x that constitutes part of the through hole 20x. The through hole 21x has a pair of planar portions 211x extending in the vertical direction and curved portions 212x that are part of the cylindrical surface and are continuous with the pair of planar portions 211x. The pair of planar portions 211x are arranged, for example, in parallel. In Figure 2, only one of the planar portions 211x is shown.

[0048] The flat portion 211x faces the flat portion 121x of the sliding portion 11 when the injection portion 10 is inserted into the through hole 20x. Similarly, the curved portion 212x faces the curved portion 121y of the sliding portion 11. When the injection portion 10 is inserted into the through hole 20x, the rotation of the axis of the through hole 20x in the circumferential direction is restricted by the flat portion 211x, and the injection portion 10 slides while maintaining its circumferential orientation.

[0049] Each of the pair of flat sections 211x is provided with a substantially elliptical recess 21z. A protrusion 121z formed on the side surface of the injection section 10 (sliding section 11) fits into the recess 21z. When the injection section 10 is inserted to a height where the protrusion 121z and the recess 21z coincide, the protrusion 121z fits into the recess 21z, maintaining the position of the injection section 10. The combination of the protrusion 121z and the recess 21z corresponds to the "first holding structure" in the present invention.

[0050] The guide body 21 has a recess 21a on its lower surface 21d into which the elastic body 22 is fitted. The lower surface 21d of the guide body 21 is "one end of the through hole in the guide body" in this invention. The recess 21a is annular in plan view. Various shapes can be adopted for the recess 21a, as long as the elastic body 22 can be fitted and held in place.

[0051] Furthermore, the guide body 21 has a recess 21b on its upper surface 21y that accommodates a portion of the compression spring 30.

[0052] The through hole 21x, recess 21a, and recess 21b are formed concentrically in a plan view.

[0053] (Elastic body) The elastic body 22 is provided at one end (lower side) of the through hole 21x in the guide body 21, and surrounds the through hole 21x (through hole 20x) in a plan view.

[0054] Here, the phrase "surrounding the through hole 21x" by the elastic body 22 includes both cases: when the elastic body 22 is formed in a continuous ring shape and surrounds the through hole 21x, and when the elastic body 22 is formed discretely (intermittently) around the through hole 21x and surrounds the through hole 21x.

[0055] The elastic body 22 is preferably a closed annular shape in plan view. The elastic body 22 has a through hole 22x that penetrates in the vertical direction. The through hole 22x communicates with the through hole 21x of the guide body 21 and constitutes a part of the through hole 20x.

[0056] The elastic body 22 has a first annular portion 221 that fits into the recess 21a, and a second annular portion 222 that is continuous with the first annular portion 221 on the inner circumference side of the first annular portion 221. In the elastic body 22, the first annular portion 221 located on the outer circumference side is thicker than the second annular portion 222 located on the inner circumference side. That is, the thickness H1 of the first annular portion 221 is greater than the thickness H2 of the second annular portion 222.

[0057] The elastic body 22 is replaceable. The replacement elastic body 22 may be a material with the same modulus of elasticity as the elastic body 22 currently in use, or it may be a second elastic body with a different modulus of elasticity than the elastic body 22. By making the medication dispensing device 1 replaceable with two or more elastic bodies 22 with different moduli, an elastic body of appropriate softness can be selected and used depending on the position where the medication dispensing device 1 is attached.

[0058] As the material for the elastic body 22, for example, a material used as the core material for a cosmetic puff can be adopted. Such materials include, for example, polyurethane, natural rubber, synthetic rubber, foamed polyethylene, polymer gel, ethylene-vinyl acetate copolymer resin, silicone resin, thermoplastic elastomer, and curable liquid silicone rubber (LSR).

[0059] (Adhesive layer) The adhesive layer 23 is provided on the lower surface 22a of the elastic body 22 and surrounds the through hole 22x in a plan view.

[0060] Here, the phrase "surrounding the through hole 22x" by the adhesive layer 23 includes both cases: when the adhesive layer 23 is formed in a continuous ring shape and surrounds the through hole 22x, and when the adhesive layer 23 is formed discretely (intermittently) around the through hole 22x and surrounds the through hole 22x.

[0061] The adhesive layer 23 is preferably a closed annular shape in plan view. The adhesive layer 23 has through holes 23x that penetrate in the vertical direction. The through holes 23x communicate with the through holes 22x of the elastic body 22 and constitute a part of the through holes 20x.

[0062] <Elastic member (second holding structure)> The compression spring (elastic member) 30 is provided between the injection section 10 and the guide section 20 and holds the injection section 10. When the compression spring 30 is not compressed (steady state), the puncture section 15 of the injection section 10 is housed inside the through hole 20x. The compression spring 30 corresponds to the "second holding structure" in the present invention, and the posture of the drug dispensing device 1 when the compression spring 30 is in a steady state corresponds to the "second posture" in the present invention.

[0063] The compression spring 30 holds the injection section 10 in a position where the puncture section 15 is housed inside the through-hole 20x before use of the medication dispensing device 1. Furthermore, as will be described later, when using the medication dispensing device 1, it creates appropriate resistance when the user pushes the injection section 10 to slide it.

[0064] In this embodiment, a compression spring 30 is shown as the elastic member of the drug dispensing device 1, but it is not limited to this. As long as the injection part 10 can be held in a second position in which the puncture part 15 is housed inside the through hole 20x in a steady state, various elastic members other than a compression spring can be used as the elastic member.

[0065] For example, the medication dispensing device 1 holds the injection part 10 with one compression spring 30, but the injection part 10 may be held using multiple compression springs. Alternatively, a known spring such as a disc spring or leaf spring may be used instead of a compression spring.

[0066] Furthermore, for the purpose of holding the injection section 10 in a second position, the second holding structure may be configured to hold the injection section 10 without having elastic force. As such a second holding structure, a jig (stopper) can be used that is sandwiched between the second member 122 of the sliding section body 12 and the guide section 20 to hold the injection section 10 in a second position.

[0067] Alternatively, as a second holding structure, the diameter of the first member 121 of the sliding body 12 may be the same as the inner diameter of the through hole 21x, and the injection part 10 may be held by friction between the first member 121 and the inner wall of the through hole 21x. Alternatively, a projection may be provided on either the outer wall of the first member 121 or the inner wall of the through hole 21x, or both, and the frictional force between the first member 121 and the through hole 21x may be increased by the projection to hold the injection part 10.

[0068] [How to use medication dispensing equipment] Figures 4-6 are explanatory diagrams illustrating the operation of the medication dispensing device 1. As shown in Figure 4, when using the medication device 1, first, the medication device 1 is attached to the skin S of the animal to be punctured (for example, the patient to be administered medication) using the adhesive layer 23, and then the injection part 10 is pressed down (indicated by M1). The injection part 10 slides within the through hole 20x and is pressed down perpendicularly to the skin S of the subject to which the lower surface of the medication device 1 is in contact.

[0069] When pressing the injection part 10, the user of the medication dispenser 1 (the patient receiving the medication) may pinch the skin S between the lower surface of the medication dispenser 1 and the user's fingers to secure the skin S.

[0070] The compression spring 30 pushes the injection part 10 upward while the injection part 10 is being pressed down. As a result, the injection part 10 moves downward by the length of the user's press, without falling onto the skin S against the user's will.

[0071] After the microneedle 152 of the puncture site 15 reaches the skin S, if the injection site 10 is pushed down further, the microneedle 152 penetrates the skin S. As described above, since the injection site 10 is pushed down approximately perpendicular to the subject's skin S, the microneedle 152 also penetrates the skin S approximately perpendicular to it.

[0072] As shown in Figure 5, when the injection section 10 is pushed down further, the protrusion 121z (see Figure 3) formed on the side surface of the injection section 10 (sliding section 11) fits into the recess 21z (see Figure 2) in the through hole 20x. As a result, the injection section 10 is held in a position (first position) in which the tip of the microneedle 152 protrudes beyond the adhesive layer 23.

[0073] In the first position, the amount by which the tip of the microneedle 152 protrudes below the lower surface of the adhesive layer 23 (protrusion amount) can be controlled by the formation positions of the convex portion 121z and the concave portion 21z. For example, it is preferable that the convex portion 121z and the concave portion 21z are formed at positions such that the above-mentioned protrusion amount is 0.1 mm or more and 10 mm or less.

[0074] With the drug delivery device 1 attached to the skin S in this manner, the drug solution L is supplied from the external device 50. The drug solution L flows through the channel 10x and is injected intradermally or subcutaneously through the through-holes of the microneedle 152.

[0075] The medication dispenser 1 is used while attached to the skin S. Therefore, if the user of the medication dispenser 1 moves around the area where the medication dispenser 1 is attached, the skin S at the area where the medication dispenser 1 is attached will move, and the surface shape of the skin S will deform, as shown in Figure 6.

[0076] Even in such cases, the medication dispensing device 1 is adhered to the skin S by the adhesive layer 23, thus preventing displacement. Furthermore, as the elastic body 22 deforms in accordance with the deformation of the skin S, the puncture portion 15 (microneedle 152) can be suitably maintained in a state where it is punctured approximately perpendicular to the skin S.

[0077] Furthermore, in order to maintain the state of the microneedles 152 when the skin S deforms as described above, it is preferable that the amount of deformation of the elastic body 22 on the inner circumference side close to the microneedles 152 is small in order to suppress displacement of the microneedles 152. Also, it is preferable that the amount of deformation of the elastic body 22 is large in order to absorb the deformation of the skin S.

[0078] In contrast, the elastic body 22 has a first annular portion 221 located on the outer circumference that is thicker than the second annular portion 222 located on the inner circumference. This allows the amount of deformation of the elastic body 22 on the inner circumference to be smaller than the amount of deformation of the outer circumference. Furthermore, the deformation of the skin S can be absorbed by the larger deformation of the outer circumference (first annular portion 221).

[0079] With the drug delivery device 1 configured as described above, it is possible to continuously administer drug solution L into the body by employing a microneedle 152.

[0080] In this embodiment, the elastic body 22 is configured as a closed annular structure having a first annular portion 221 and a second annular portion 222, but it is not limited to this configuration. The elastic body 22 may consist only of the first annular portion 221.

[0081] Furthermore, although the elastic body 22 is designed to fit into the recess 21a of the guide body 21 and be replaceable, it is not limited to this and may also be attached to the guide body 21.

[0082] Preferred embodiments of the present invention have been described above with reference to the attached drawings, but the present invention is not limited to these examples. The shapes and combinations of the constituent members shown in the above examples are merely examples, and can be modified in various ways based on design, specifications, etc., without departing from the spirit of the present invention. [Explanation of symbols]

[0083] 1...Medication device, 10...Injection part, 10x...Flow path, 11...Sliding part, 12...Sliding part body, 12x, 13x, 20x, 21x, 22x, 23x...Through hole, 13...Flow path member, 20...Guide part, 21...Guide part body, 21a, 21b, 21z...Recess, 22...Elastic body, 23...Adhesive layer, 30...Compression spring (elastic member), 50...External device, 121z...Protrusion, 152...Microneedle, L...Medication solution, S...Skin

Claims

1. A cylindrical injection port for puncturing the skin and injecting the drug solution into the body, It has a through hole into which the injection part is inserted, and a guide part that guides the sliding direction of the injection part in the through hole, The injection section comprises a cylindrical sliding section in which a flow path for the liquid medicine is formed, It has a microneedle provided at the end of the sliding part and communicating with the flow path, The guide portion comprises a guide portion body having the through hole, An elastic body provided on one end side of the through hole in the main body of the guide section, The elastic body has an adhesive layer provided on its surface, A drug dispensing device having a first holding structure that holds the injection portion in a first position in which the tip of the microneedle protrudes beyond the adhesive layer, wherein at least one of the injection portion and the guide portion.

2. The drug dispensing device according to claim 1, further comprising a second holding structure that holds the injection portion in a second position in which the tip of the microneedle is housed within the through-hole.

3. The drug dispensing device according to claim 2, wherein the second holding structure is an elastic member provided between the injection portion and the guide portion, and holds the injection portion in the second position.

4. The medication dispensing device according to any one of claims 1 to 3, wherein the elastic body surrounds the periphery of the through hole.

5. The medication dispensing device according to claim 4, wherein the elastic body is a closed annular shape in plan view.

6. The medication dispensing device according to claim 4, wherein the elastic body is thicker on the outer circumference than on the inner circumference.

7. The medication dispensing device according to any one of claims 1 to 3, wherein the guide body has a recess on one end side into which the elastic body is fitted.

8. The drug dispensing device according to any one of claims 1 to 3, wherein the elastic body is replaceable.

9. The drug dispensing device according to claim 8, further comprising a second elastic body having a different elastic modulus from the aforementioned elastic body as a component interchangeable with the aforementioned elastic body.

10. The sliding part comprises a cylindrical sliding part body in which a part of the flow path is formed, The sliding part body has a flow path member that communicates with a part of the flow path and is connectable to an external device for injecting the drug solution into the drug dispensing device, The drug dispensing device according to any one of claims 1 to 3, wherein the flow channel member is detachable from the sliding body.

11. The drug dispensing device according to claim 10, further comprising a second flow channel member that can be connected to a second external device as a component interchangeable with the aforementioned flow channel member.

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