External components

Abstract

The present invention provides an external composition containing an ultraviolet scattering agent that exhibits excellent transparency and a pleasant feel. [Solution] A topical composition containing an ultraviolet scattering agent (A), The ultraviolet scattering agent (A) is an external composition comprising an ultraviolet scattering agent (A1) whose surface has been treated with a surface treatment agent and an ultraviolet scattering agent (A2) whose surface has been treated with a surface treatment agent of a different type than the aforementioned surface treatment agent.

Description

Technical Field

[0001] The present invention relates to an external composition. Specifically, it relates to an external composition containing an ultraviolet scattering agent.

Background Art

[0002] In external compositions such as sunscreen preparations that protect the skin from ultraviolet rays, ultraviolet absorbers (UV chemical absorbers) and ultraviolet scattering agents are widely used. For example, Patent Document 1 describes a sunscreen agent containing 2-ethylhexyl paramethoxycinnamate as an ultraviolet absorber and zinc oxide as an ultraviolet scattering agent.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] While ultraviolet scattering agents can defend against ultraviolet rays with a wide range of wavelengths from UVA to UVB, it is known that there are problems in appearance such as becoming whitish and opaque when applied to the skin, and problems in use such as stickiness, bulkiness, and powdery feeling. In response to such problems, attempts have been made to improve transparency and usability by controlling the particle size of the ultraviolet scattering agent or treating the surface of the ultraviolet scattering agent with an organic substance. However, in formulation technology, methods for solving the above problems caused by ultraviolet scattering agents have not yet been sufficiently studied.

Means for Solving the Problems

[0005] As a result of intensive research in view of the above circumstances, the present inventors have found that an external composition having a specific composition can solve the above problems.

[0006] In other words, the present invention provides the following [1] to

[13] . [1] A topical composition containing an ultraviolet scattering agent (A), The ultraviolet scattering agent (A) is an external composition comprising an ultraviolet scattering agent (A1) whose surface has been treated with a surface treatment agent and an ultraviolet scattering agent (A2) whose surface has been treated with a surface treatment agent of a different type than the aforementioned surface treatment agent. [2] The topical composition according to [1], wherein the surface treatment agent comprises one or more selected from the group consisting of fatty acid components, silicone components, and silane compounds. [3] The topical composition according to [1] or [2], wherein the ultraviolet scattering agent (A1) is titanium dioxide surface-treated with a surface treatment agent, and the ultraviolet scattering agent (A2) is zinc oxide surface-treated with a surface treatment agent. [4] The topical composition according to any one of [1] to [3], wherein the ultraviolet scattering agent (A1) is titanium dioxide surface-treated with a surface treatment agent containing a fatty acid component, and the ultraviolet scattering agent (A2) is zinc oxide surface-treated with a surface treatment agent containing a silane compound. [5] The topical composition according to any one of [1] to [4], wherein the mass ratio (A1 / A2) of the ultraviolet scattering agent (A1) to the ultraviolet scattering agent (A2) is 5 / 95 to 50 / 50. [6] The topical composition according to any one of [1] to [5], wherein the average particle size of the ultraviolet scattering agent (A) is 50 nm or less. [7] The topical composition according to any one of [1] to [6], wherein the total content of the ultraviolet scattering agent (A) is 18% by mass or more relative to the total amount of the topical composition. [8] Furthermore, the topical composition according to any one of [1] to [7] contains a liquid polar oil and a solid wax. [9] A topical composition according to any one of [1] to [8], which does not contain an ultraviolet absorber.

[10] The topical composition according to [8], wherein the viscosity of the topical composition at 95°C is 100 to 4000 mPa·s.

[11] The topical composition according to [8] or [9], wherein the hardness of the topical composition at 25°C is 10 to 200 gf.

[12] The topical composition according to any one of [8] to

[11] , wherein the topical composition is a solid topical composition.

[13] The topical composition according to any one of [8] to

[12] , wherein the topical composition is in the form of a stick.

[0007] Furthermore, the present invention provides the following

[14] .

[14] A topical composition containing an ultraviolet scattering agent (A), The average particle size of the ultraviolet scattering agent (A) is 50 nm or less. An external composition in which the total content of the ultraviolet scattering agent (A) is 18% by mass or more relative to the total amount of the external composition. [Effects of the Invention]

[0008] According to one embodiment of the present invention, in a topical composition containing an ultraviolet scattering agent, the dispersion of the ultraviolet scattering agent is promoted, resulting in a topical composition with excellent transparency and feel.

[0009] For example, according to one embodiment of the present invention, by including an ultraviolet scattering agent surface-treated with a surface treatment agent and an ultraviolet scattering agent surface-treated with a surface treatment agent of a different type from the aforementioned surface treatment agent, the dispersion of the ultraviolet scattering agent is promoted, resulting in a topical composition with excellent transparency and feel. Furthermore, according to one embodiment of the present invention, the dispersibility of the ultraviolet scattering agent is promoted, and the uniformity when applied is increased, so it can also be expected to have the effect of improving ultraviolet shielding performance. [Modes for carrying out the invention]

[0010] Embodiments of the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

[0011] In this specification, when expressed as "X to Y" (where X and Y are arbitrary numbers), unless otherwise specified, it includes the meaning of "X or more and Y or less" and also the meaning of "preferably more than X" or "preferably less than Y". In addition, in this specification, "α and / or β" (where α and β are arbitrary configurations or components) means three combinations: "only α", "only β", and "both α and β", unless otherwise specified. Also, in this specification, for numerical ranges described stepwise, the upper limit value or lower limit value of a numerical range at a certain step can be arbitrarily combined with the upper limit value or lower limit value of a numerical range at another step. Also, in the numerical ranges described in this specification, the upper limit value or lower limit value of the numerical range can be replaced with the value shown in the examples or formulation examples.

[0012] <External composition> An external composition according to an embodiment of the present invention (hereinafter sometimes referred to as "this external composition") is an external composition containing an ultraviolet scattering agent (A), and the ultraviolet scattering agent (A) preferably includes an ultraviolet scattering agent (A1) surface-treated with a surface treatment agent and an ultraviolet scattering agent (A2) surface-treated with a surface treatment agent different from the above surface treatment agent. Note that the present invention is not limited to the above embodiment.

[0013] 〔Ultraviolet scattering agent (A)〕 This external composition contains an ultraviolet scattering agent (A). As the ultraviolet scattering agent (A), conventionally known ultraviolet scattering agents can be appropriately used. The ultraviolet scattering agent (A) may be used alone or in combination of two or more, and it is preferable to use two or more in combination.

[0014] s The total content of the ultraviolet scattering agent (A) can be appropriately set according to the type and amount of other components, dosage form, etc., and is not limited, but in one embodiment, from the viewpoint of significantly demonstrating the effects of the present invention and from the viewpoint of enhancing ultraviolet shielding properties, it is preferably 18% by mass or more, more preferably 18 to 45% by mass, even more preferably 20 to 40% by mass, and even more preferably 25 to 35% by mass, based on the total amount of the topical composition.

[0015] Examples of ultraviolet scattering agents (A) include inorganic powders, particularly metal oxides, and are not particularly limited, but include zinc oxide, titanium oxide, cerium oxide, iron oxide, tungsten oxide, zirconium oxide, etc. Among these, zinc oxide, titanium oxide, and cerium oxide are preferred from the viewpoint of significantly achieving the effects of the present invention, and zinc oxide and titanium oxide are more preferred.

[0016] The shape of the inorganic powder constituting the ultraviolet scattering agent (A) is not particularly limited, but examples include spherical, elliptical, needle-shaped, spindle-shaped, or plate-shaped. Among these, a spherical shape is preferred from the viewpoint of significantly achieving the effects of the present invention.

[0017] As the ultraviolet scattering agent (A), it is preferable that the inorganic powder is used as the base material and the surface of the base material is coated with any surface treatment agent. Conventional surface treatment agents can be used as appropriate. For example, although not limited to the following, examples of surface treatment agents include those containing hydrophobic treatment components such as fatty acid components, silicone components, silane compounds, metal soaps, fluorine, amino acids, fatty acid esters, and alkyl titanates. These may be used individually or in combination of two or more.

[0018] Examples of the aforementioned fatty acid components include fatty acids having 12 to 22 carbon atoms. Specifically, these include isostearic acid, stearic acid, 12-hydroxystearic acid, palmitic acid, lauric acid, myristic acid, behenic acid, oleic acid, rosinic acid, and the like. Among these, fatty acids having 16 to 20 carbon atoms are preferred, and isostearic acid and stearic acid are particularly preferred.

[0019] Examples of the silicone component include methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, methylcyclopolysiloxane, dodecamethylcyclohexasiloxane, tetradecamethylhexasiloxane, dimethylsiloxane / methyl(polyoxyethylene)siloxane / methyl(polyoxypropylene)siloxane copolymer, dimethylsiloxane / methyl(polyoxyethylene)siloxane copolymer, dimethylsiloxane / methyl(polyoxypropylene)siloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, (alkyl acrylate / dimethicone) copolymer, and the like.

[0020] Examples of the silane compounds include alkylsilanes. Specifically, examples include alkoxyalkylsilanes such as triethoxycaprylylsilane, methyltrimethoxysilane, ethyltrimethoxysilane, hexyltrimethoxysilane, octyltrimethoxysilane, and octyltriethoxysilane, as well as fluoroalkylsilanes such as trifluoromethylethyltrimethoxysilane and heptadecafluorodecyltrimethoxysilane. Among these, alkoxyalkylsilanes are preferred.

[0021] The aforementioned alkoxyalkylsilane is (C n H 2n+1 ) a Si(OC m H 2m+1 ) b This is a silicon compound represented by the formula shown. Here, n is preferably an integer from 1 to 18, m is an integer from 1 to 3, a is an integer from 4 to b, and b is an integer from 1 to 3. Among these, triethoxycaprylylsilane [(C2H5O)3Si(CH2)7CH3] is preferred.

[0022] Examples of the aforementioned metal soaps include aluminum stearate, calcium stearate, and magnesium stearate. Examples of the fluorine include perfluoroalkyl phosphate esters and perfluoro alcohols. Examples of the aforementioned amino acids include N-acyl glutamic acid. Examples of the aforementioned fatty acid esters include dextrin fatty acid esters, cholesterol fatty acid esters, sucrose fatty acid esters, and starch fatty acid esters.

[0023] Examples of the alkyl titanates include pyrophosphate-type alkyl titanates, phosphite-type alkyl titanates, amino acid-type alkyl titanates, and long-chain carboxylic acid-type alkyl titanates. Examples of the alkyl titanates include tetraisopropylbis(dioctylphosphite) titanate, tetraoctylbis(ditridecylphosphite) titanate, tetra(2,2-diallyloxymethyl-1-butyl)bis(ditridecylphosphite) titanate, isopropyl tri(dioctyl pyrophosphate) titanate, bis(dioctyl pyrophosphate) oxyacetate titanate, bis(dioctyl pyrophosphate) ethylene titanate, isopropyl tri(N-amidoethyl-aminoethyl) titanate, isopropyl triisostearoyl titanate, isopropyl trioctanoyl titanate, isopropyl dimethacrylate isostearoyl titanate, isopropyl isostearoyl diacrylic titanate, and diisostearoylethylene titanate.

[0024] In addition, inorganic surface treatment agents can be used as surface treatment agents. Examples of inorganic surface treatment agents include silica, hydrated silica, alumina, zirconia, titania, and the like.

[0025] Surface treatment agents can be used alone or in combination of two or more. For example, a base material that has been surface-treated with an inorganic surface treatment agent such as silica and alumina may be further surface-treated with a surface treatment agent containing a hydrophobic treatment component. Specifically, for example, titanium oxide that has been surface-treated with an inorganic surface treatment agent containing aluminum hydroxide and silica may be further surface-treated with a surface treatment agent containing a hydrophobic treatment component such as triethoxycaprylylsilane.

[0026] In one embodiment of this external composition, for example, an ultraviolet scattering agent that has been surface-treated with a surface treatment agent containing one or more inorganic surface treatment agents and one or more hydrophobic treatment components may be used. For example, in one embodiment of the present external composition, an ultraviolet scattering agent may be used that has been surface-treated with a surface treatment agent that includes, for example, one or more inorganic surface treatment agents selected from the group consisting of silica, hydrated silica, alumina, zirconia, and titania, and one or more hydrophobic treatment components selected from the group consisting of fatty acid components, silicone components, silane compounds, metal soaps, fluorine, amino acids, fatty acid esters, and alkyl titanates.

[0027] In an ultraviolet scattering agent surface-treated with a surface treatment agent, the total content of the surface treatment agent relative to the total content (100% by mass) of the base material and the surface treatment agent is not particularly limited, but is, for example, 1 to 50% by mass, preferably 3 to 40% by mass, and more preferably 5 to 30% by mass.

[0028] In this specification, "surface treatment" means that a surface treatment agent comes into contact with or bonds to a base material through interaction between the two, and that at least a portion of the surface of the base material is coated with the surface treatment agent. Examples of such contact include physical adsorption. Examples of such bonding include ionic bonds, hydrogen bonds, and covalent bonds. Furthermore, in this specification, "surface treatment" also includes the meaning that a surface treatment agent comes into contact with or bonds to an already surface-treated base material through interaction between the two, thereby coating at least a portion of the surface of the surface-treated base material with the surface treatment agent.

[0029] The average particle size of the ultraviolet scattering agent (A) is not particularly limited, but from the viewpoint of significantly achieving the effects of the present invention, it is, for example, 50 nm or less. From the viewpoint of promoting the dispersion of the ultraviolet scattering agent and improving the transparency and feel of the topical composition, it is preferably 1 to 50 nm, more preferably 3 to 40 nm, and even more preferably 5 to 30 nm. The aforementioned average particle diameter refers to a value obtained from the manufacturer, such as from a catalog of commercially available products, or the diameter of the primary particles of the powder measured by a commonly used method. For example, it is a value obtained from a transmission electron microscope image as the arithmetic mean of the length of the long axis and the length of the short axis of the particle.

[0030] (Different surface treatment agents) In one embodiment of the present invention, it is preferable that the ultraviolet scattering agent (A) contains an ultraviolet scattering agent (A1) whose surface has been treated with a surface treatment agent and an ultraviolet scattering agent (A2) whose surface has been treated with a surface treatment agent of a different type than the aforementioned surface treatment agent. That is, in this external composition, it is preferable to use in combination an arbitrary ultraviolet scattering agent whose surface has been treated with a surface treatment agent and another ultraviolet scattering agent whose surface has been treated with a surface treatment agent of a different type than the surface treatment agent used for the aforementioned arbitrary ultraviolet scattering agent. By using these ultraviolet scattering agents in combination, the dispersion of the ultraviolet scattering agents is promoted, resulting in an external composition with excellent transparency and feel.

[0031] Conventionally, topical compositions containing UV scattering agents have been known to have appearance problems such as becoming whitish and opaque when applied to the skin, as well as usability problems such as stickiness, dryness, and powderiness. Attempts have been made to improve transparency and usability by controlling the particle size of the UV scattering agent or by treating the surface of the UV scattering agent with organic matter, but methods for solving the aforementioned problems caused by UV scattering agents in formulation technology have not yet been sufficiently investigated. Moreover, it is not known that combining a UV scattering agent surface-treated with a surface treatment agent and a UV scattering agent surface-treated with a different type of surface treatment agent can promote the dispersion of the UV scattering agent and result in a topical composition with superior transparency and usability.

[0032] As mentioned above, the average particle diameter of UV scattering agent (A1) and the average particle diameter of UV scattering agent (A2) are, for example, 50 nm or less. The average particle diameter of UV scattering agent (A1) and the average particle diameter of UV scattering agent (A2) may be the same or different. Furthermore, the average particle diameter of UV scattering agent (A1) and the average particle diameter of UV scattering agent (A2) can be appropriately set within the range exemplified for the average particle diameter of UV scattering agent (A).

[0033] The mass ratio (A1 / A2) of the ultraviolet scattering agent (A1) to the ultraviolet scattering agent (A2) can be appropriately set according to the type and amount of other components, dosage form, etc., and is not limited thereto. However, in one embodiment, from the viewpoint of significantly achieving the effects of the present invention, 5 / 95 to 50 / 50 is preferred, more preferably 10 / 90 to 50 / 50, and even more preferably 20 / 80 to 50 / 50.

[0034] A preferred embodiment of the present invention is a topical composition containing an ultraviolet scattering agent (A), from the viewpoint of promoting the dispersion of the ultraviolet scattering agent and improving the transparency and feel of the topical composition, wherein the ultraviolet scattering agent (A) is titanium dioxide or zinc oxide surface-treated with a surface treatment agent containing a fatty acid component, and titanium dioxide or zinc oxide surface-treated with a surface treatment agent containing a silane compound. Furthermore, in a preferred embodiment of the present invention, the ultraviolet scattering agent (A1) is titanium oxide surface-treated with a surface treatment agent containing a fatty acid component, and the ultraviolet scattering agent (A2) is zinc oxide surface-treated with a surface treatment agent containing a silane compound.

[0035] Furthermore, from a similar viewpoint, in one embodiment of the present invention, it is preferable that the ultraviolet scattering agent (A1) is titanium oxide surface-treated with a surface treatment agent containing a fatty acid component and aluminum hydroxide, and that the ultraviolet scattering agent (A2) is zinc oxide surface-treated with a surface treatment agent containing an alkoxyalkylsilane.

[0036] Furthermore, in one embodiment of the present invention, from the viewpoint of promoting the dispersion of ultraviolet scattering agents and improving the transparency and feel of the topical composition, it is preferable to use titanium dioxide with an average particle size of 3 to 20 nm and zinc oxide with an average particle size of 3 to 40 nm, and particularly preferable to use titanium dioxide with an average particle size of 5 to 10 nm and zinc oxide with an average particle size of 5 to 30 nm.

[0037] In this specification, "different surface treatment agents" means that they do not contain the same type of hydrophobic treatment component in each other. Specifically, for example, when using a surface treatment agent in which ultraviolet scattering agent (A1) contains any one or more hydrophobic treatment components (a1) selected from the group consisting of fatty acid components, silicone components, silane compounds, metal soaps, fluorine, amino acids, fatty acid esters, and alkyl titanates, and using a surface treatment agent in which ultraviolet scattering agent (A2) is selected from the group consisting of fatty acid components, silicone components, silane compounds, metal soaps, fluorine, amino acids, fatty acid esters, and alkyl titanates, excluding the aforementioned hydrophobic treatment component (a1), then ultraviolet scattering agent (A1) and ultraviolet scattering agent (A2) do not contain the same type of hydrophobic treatment component in each other, and therefore, both are treated with different surface treatment agents.

[0038] Specifically, for example, in one embodiment of the present invention, if the external composition includes an ultraviolet scattering agent (A1) whose surface is treated with a surface treatment agent containing a hydrophobic treatment component (a1), and an ultraviolet scattering agent (A2) whose surface is treated with a surface treatment agent containing a hydrophobic treatment component (a2) different from the aforementioned hydrophobic treatment component, the dispersion of the ultraviolet scattering agent is promoted, resulting in an external composition with excellent transparency and feel.

[0039] More specifically, for example, if the ultraviolet scattering agent (A1) uses a fatty acid component as a hydrophobic treatment component, and the ultraviolet scattering agent (A2) does not use a fatty acid component but instead uses one or more hydrophobic treatment components selected from the group consisting of silicone components, silane compounds, metal soaps, fluorine, amino acids, fatty acid esters, and alkyl titanates, then both are treated with different surface treatment agents, which promotes the dispersion of the ultraviolet scattering agents and results in a topical composition with excellent transparency and feel.

[0040] In one embodiment of the present invention, for example, it is preferable to use one or more hydrophobic treatment components selected from the group consisting of fatty acid components, silicone components, and silane compounds in the ultraviolet scattering agent (A1), and to use one or more hydrophobic treatment components selected from the group consisting of fatty acid components, silicone components, and silane compounds, excluding the species to which the hydrophobic treatment component belongs, in the ultraviolet scattering agent (A2). Specifically, if the surface treatment agent used for the ultraviolet scattering agent (A1) contains a fatty acid component, it is preferable that the surface treatment agent used for the ultraviolet scattering agent (A2) does not contain a fatty acid component, but rather contains, for example, a silicone component and / or a silane compound.

[0041] [Other ingredients] This external composition is obtained by mixing component (A) with various components used in cosmetics, quasi-drugs, or pharmaceuticals. In one preferred embodiment of the present invention, it is preferable to provide an external composition that is solid at room temperature (25°C) in order to effectively promote the dispersion of ultraviolet scattering agents and improve the transparency and feel of the external composition.

[0042] Examples of the base of this external composition include oils. Examples of oils include polar oils and non-polar oils. Examples of polar oils include ester oils, fats and oils, waxes, higher alcohols, and sterols (phytosterols, cholesterol, etc.). Examples of non-polar oils include hydrocarbon oils and silicone oils. The total content of the oily agent can be set appropriately depending on the type and amount of other components, dosage form, etc., and is not limited, but for example, it is 10 to 90% by mass of the total amount of the topical composition, and in one embodiment, from the viewpoint of improving the transparency and feel of the topical composition, it is preferably 20 to 80% by mass, and more preferably 30 to 70% by mass.

[0043] Examples of ester oils include isopropyl myristate, butyl myristate, decyl myristate, myristyl myristate, cetyl myristate, isopropyl palmitate, cetyl palmitate, ethyl stearate, butyl stearate, stearyl stearate, isocetyl stearate, hexyl laurate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, decyl oleate, oleyl oleate, isodecyl oleate, cetyl octanoate, 2-octyldodecyl myristate, dimethyl octyl 2-Octyldodecyl Tanate, Hexyldecyl Dimethyloctanoate, Diethyl Sebacate, Diisopropyl Sebacate, Di-2-Ethylhexyl Sebacate, 2-Hexyldecyl Myristate, 2-Hexyldecyl Palmitate, Diisopropyl Adipate, 2-Hexyldecyl Adipate, Isocetyl Isostearate, Isostearyl Isostearate, Isononyl Isononanoate, Isotridecyl Isononanoate, Cholesteryl 12-Hydroxystearylate, Cholesteryl Stearate, Cholesteryl Oleate, Macadamia Nut Fatty Acid Phyto Sterillyl, phytosteryl oleate, inulin stearate, ethylene glycol di-2-ethylhexylate, cetyl 2-ethylhexanoate, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, tri-2-ethylhexyl trimellitate, tridecyl trimellitate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate Trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, glycerin trimyristate, caprylic / capric triglyceride, medium-chain triglyceride, caprylic / capric / myristic / stearic triglyceride, glyceryl tri-2-ethylhexanoate (triethylhexanoin), castor oil fatty acid methyl ester, diisobutyl adipate, phytosteryl / octyldodecyl lauroyl glutamate, octyldodecyl / phytosteryl / behenyl lauroyl glutamate,Examples include di-2-heptyl undecyl adipate, diisostearyl malate, cetyl lactate, myristyl lactate, diethoxyethyl succinate, diethylhexyl succinate, bisethoxydiglycol cyclohexane-1,4-dicarboxylic acid, lanolin acetate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, dimer dilinoleyl dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleyl dimer dilinoleate, dipentaerythrityl tripolyhydroxystearate, and glyceryl tri(behenate / isostearate / eicosanedioate).

[0044] Examples of oils and fats include avocado oil, linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, safflower oil, apricot kernel oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, sasanqua oil, rapeseed oil, sesame oil, cocoa butter, coconut oil, hydrogenated coconut oil, palm oil, palm kernel oil, Japanese wax kernel oil, Japanese wax, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, kukui nut oil, hazelnut oil, and shea butter.

[0045] Examples of waxes include candelilla wax, rice bran wax, cotton wax, carnauba wax, lanolin, isopropyl lanolin fatty acid, POE lanolin alcohol ether, POE lanolin alcohol acetate, polyethylene glycol lanolin fatty acid, POE hydrogenated lanolin alcohol ether, shellac wax, and beeswax.

[0046] Examples of higher alcohols include alcohols with 12 to 22 carbon atoms. Specific examples of higher alcohols include linear saturated higher alcohols such as lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, arachidyl alcohol, and behenyl alcohol; unsaturated higher alcohols such as oleyl alcohol and cerachidyl alcohol; and branched higher alcohols such as hexyldecanol, isostearyl alcohol, octyldodecanol, decyltetradecanol, lanolin alcohol, and isostearyl glyceryl ether.

[0047] Examples of hydrocarbon oils include petrolatum, squalane, squalene, liquid paraffin, pristane, polyisobutylene, polyethylene wax, and microcrystalline wax.

[0048] Examples of silicone oils include methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane, decamethyltetrasiloxane, methylcyclopentasiloxane, highly polymerized methylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, methylhydrogenpolysiloxane, siloxanes such as methyltrimethicone, dimethiconol, and dimethiconol crosspolymer, alkyl-modified silicones such as caprylyl methicone, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cross-linked methylpolysiloxane, cross-linked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, silicone-alkyl chain-comodified polyether-modified silicone, silicone-alkyl chain-comodified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resins.

[0049] Other bases for this external composition include water-based bases other than water, such as lower alcohols and polyhydric alcohols. The total content of the aqueous base can be appropriately set according to the type and amount of other components, dosage form, etc., and is not limited, but for example, it is 10% by mass or less of the total amount of the topical composition, and in one embodiment, from the viewpoint of improving the transparency and feel of the topical composition, it is preferably 5% by mass or less, and more preferably 3% by mass or less.

[0050] Examples of lower alcohols include low molecular weight alcohols having one hydroxyl group, such as ethanol and isopropyl alcohol.

[0051] Examples of polyhydric alcohols include low molecular weight alcohols having two or more hydroxyl groups, such as glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, ethylene glycol, diethylene glycol, isoprene glycol, 1,3-butylene glycol, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, decanediol, neopentyl glycol, sorbitol, xylitol, erythritol, and mannitol.

[0052] In one embodiment of this external composition, it is preferable that it is substantially water-free, and the total water content is 1% by mass or less, preferably 0.5% by mass or less, more preferably 0.1% by mass or less, and even more preferably 0% by mass, based on the total amount of the external composition.

[0053] In one embodiment of this external composition, it is preferable to use a solid wax as a base. A solid wax is a substance that exhibits waxy physical properties (specifically, water resistance, plasticity, gloss, and / or opacity, etc.) and is solid at room temperature (25°C).

[0054] As a solid wax, Specifically, these include petroleum-derived waxes such as paraffin wax and microcrystalline wax; synthetic waxes such as polyethylene wax, Fischer-Tropsch wax, hydrogenated castor oil, and polypropylene wax; silicone waxes such as (stearoxymethicone / dimethicone) copolymer, cetearyl methicone, and alkyl (C30-45) cetearyl dimethicone crosspolymer; carnauba wax, candelilla wax, wood wax, rice bran wax, laurel wax, lacquer wax, sugarcane wax, palm wax, and orange wax. Examples of waxes include plant-derived waxes such as citrus peel wax, orange blossom wax, jasmine flower wax, narcissus flower wax, white bayberry fruit wax, sweet acacia flower wax, and tuberose flower wax; animal-derived waxes such as beeswax, bleached beeswax, whale wax, shellac wax, and lanolin; mineral-derived waxes such as montan wax, ozokerite, and ceresin wax; and solid higher alcohols such as cetyl alcohol (also known as cetanol, palmityl alcohol, etc.), stearyl alcohol, and behenyl alcohol. Among these, petroleum-derived waxes such as paraffin wax and microcrystalline wax are preferred from the viewpoint of effectively promoting the dispersion of ultraviolet scattering agents and improving the transparency and feel of topical compositions; and synthetic waxes such as polyethylene wax, Fischer-Tropsch wax, hydrogenated castor oil, and polypropylene wax are preferred.

[0055] The melting point of the solid wax is, for example, 40 to 150°C, preferably 40 to 130°C, and more preferably 40 to 100°C. Furthermore, from the viewpoint of effectively promoting the dispersion of the ultraviolet scattering agent and improving the transparency and feel of the topical composition, the melting point of the solid wax may be 50 to 100°C, 60 to 100°C, 70 to 100°C, etc.

[0056] The total content of solid wax can be set appropriately depending on the type and amount of other components, dosage form, etc., and is not limited, but for example, it is 5 to 30% by mass of the total amount of the topical composition, and in one embodiment, from the viewpoint of improving the transparency and feel of the topical composition, it is preferably 8 to 25% by mass, and more preferably 10 to 20% by mass.

[0057] Furthermore, in one preferred embodiment of this external composition, it is preferable to use a liquid polar oil as the base. Among liquid polar oils, those with an IOB value of 0.1 to 0.5 are particularly preferred. For example, triethylheysanoin (IOB=0.35), isononyl isononanoate (IOB=0.2), cetyl 2-ethylhexanoate (IOB=0.13), isotridecyl isononanoate (IOB=0.15), 2-octyldodecanol (IOB=0.26), neopentyl glycol dicaprate (IOB=0.25), propylene glycol dicaprate (IOB=0.26), diisostearyl malate (IOB=0.28), trimethylolpropane triisostearate (IOB=0.16), isopropyl myristate (IOB=0.18), isodecyl isononanoate (IOB=0.19), octyldodecyl neopentanoate (IOB=0.13), isostearyl neopentanoate (IOB=0.14), palmitic acid Examples include isopropyl (IOB=0.16), hexyl laurate (IOB=0.17), hexyldecyl ethylhexanoate (IOB=0.13), isopropyl isostearate (IOB=0.15), isodecyl benzoate (IOB=0.23), ethylhexyl isononanoate (IOB=0.2), isodecyl neopentanoate (IOB=0.22), ethylhexyl ethylhexanoate (IOB=0.2), diglyceryl stearoyl oxystearate (IOB=0.11), diglyceryl tetraisostearate (IOB=0.17), diglyceryl triisostearate (IOB=0.26), tridecyl trimellitate (IOB=0.28), and tri(caprylic / capric acid) glyceryl (IOB=0.32).

[0058] The total content of liquid polar oil (preferably liquid polar oil with an IOB value of 0.1 to 0.5) can be appropriately set according to the type and amount of other components, dosage form, etc., and is not limited, but for example, it is 10 to 80% by mass of the total amount of the topical composition, and in one embodiment, from the viewpoint of improving the transparency and feel of the topical composition, it is preferably 15 to 70% by mass, and more preferably 20 to 65% by mass.

[0059] The boundary between non-polar oils and polar oils is not particularly limited, but for example, oils with an IOB value of 0.05 or higher can be distinguished as "polar oils," and other oils, i.e., oils with an IOB value of less than 0.05 (0 or more and less than 0.05), can be distinguished as "non-polar oils." Also, "solid" means solid or semi-solid at room temperature (25°C), and "liquid" means liquid at room temperature (25°C).

[0060] Examples of ingredients that may be incorporated into this external composition include antioxidants, surfactants, thickeners, preservatives, pH adjusters, stabilizers, chelating agents, UV absorbers, colorants, pearlescent agents, fragrances, moisturizing ingredients, vitamins, cooling agents, peptides or their derivatives, blood circulation promoting ingredients, cell activating ingredients, astringent ingredients, plant extracts, and whitening ingredients (excluding ingredients corresponding to (A) and the base). These can be used individually or in combination of two or more.

[0061] Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, p-hydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivatives (ascorbic acid stearate, ascorbic acid palmitate, ascorbyl dipalmitate, ascorbic acid monophosphate, ascorbic acid diphosphate, ascorbic acid triphosphate, ascorbic acid sulfate, etc.), tocopherol, tocopherol derivatives (tocopherol acetate, tocopherol succinate, tocopherol calcium succinate, etc.), erythorbic acid, L-cysteine ​​hydrochloride, lycopene, glutathione, propyl gallate, tannic acid, epigallocatechin, anthocyanins, hydroxytyrosol, norhydroguaceretenoic acid, caffeic acid, and enzymes (catalase, superoxide dismutase, glutathione peroxidase, elastase, etc.).

[0062] Examples of surfactants include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan penta-2-ethylhexyl diglycerol sorbitan, and sorbitan tetra-2-ethylhexyl diglycerol sorbitan; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene Hydrogenated castor oil derivatives such as ethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), and polyoxyethylene hydrogenated castor oil 80; polyoxyethylene (20) sorbitan monolauryl acid (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), and polyoxyethylene (20) isostearate Examples include polyoxyethylene sorbitan fatty acid esters such as rubitan; polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ethers; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine; silicone-based surfactants such as polyoxyethylene methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone; natural surfactants such as phospholipids, surfactin, and saponins; fatty acid amidoamines such as diethylaminoethyl stearate and diethylaminopropyl stearate; alkylamines such as trilaurylamine, dimethylstearylamine, and di-2-ethylhexylamine; and betaine-based amphoteric surfactants such as dimethylaminopropyl stearate and lauryl hydroxysulfobetaine.

[0063] Examples of thickening agents include guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl acrylate methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, macrogol, sodium chondroitin sulfate, hyaluronic acid, and cellulose-based thickening agents (methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and carboxyethylcellulose, etc.).

[0064] Examples of preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, alkanediols, and glycerin fatty acid esters.

[0065] Examples of pH adjusters include inorganic acids (hydrochloric acid and sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, and sodium succinate, etc.), inorganic bases (potassium hydroxide and sodium hydroxide, etc.), and organic bases (triethanolamine, diisopropanolamine, and triisopropanolamine, etc.).

[0066] Examples of stabilizers include sodium polyacrylate, dibutylhydroxytoluene, and butylhydroxyanisole.

[0067] Examples of chelating agents include EDTA-disodium salt and EDTA-calcium-disodium salt.

[0068] Examples of UV absorbers include salicylic acid-based UV absorbers, cinnamic acid-based UV absorbers, benzoylmethane-based UV absorbers, benzoic acid ester derivative UV absorbers, triazine derivative UV absorbers, benzalmalonate derivative UV absorbers, octocrylene-based UV absorbers, imidazole sulfonic acid derivative UV absorbers, and benzophenone derivative UV absorbers.

[0069] Specifically, for example, 2-ethylhexyl paramethoxycinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-[4-(diethylamino)-2-hydroxybenzoyl]hexyl benzoate, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol], 2,4 Examples include -bis-[{4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, dimethicone diethyl benzalmalonate, 2-cyano-3,3-diphenylpropane-2-enoic acid 2-ethylhexyl ester, and 2-phenylbenzimidazole-5-sulfonic acid.

[0070] Examples of colorants include inorganic pigments, organic dyes, and natural dyes. Examples of inorganic pigments include mica such as sericite, phlogopite, muscovite, red mica, biotite, and lithium mica, as well as extender pigments such as synthetic mica, kaolin, talc, alumina, boron nitride, plate-like barium sulfate, plate-like titanium dioxide, plate-like cerium oxide, silicic acid, anhydrous silicic acid, magnesium silicate, magnesium oxide, and aluminum oxide.

[0071] Examples of pearlescent luster imparting agents include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

[0072] Examples of fragrances include herbal essential oils such as lavender oil, rosemary oil, clary sage oil, thyme oil, bergamot oil, and eucalyptus oil; mint essential oils such as peppermint oil, spearmint oil, and peppermint oil; citrus essential oils such as orange oil, lemon oil, and grapefruit oil; and various other essential oils and blended fragrances.

[0073] Examples of moisturizing ingredients include polyhydric alcohols such as glycerin, dipropylene glycol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, diglycerin, pentanediol, hexanediol, and octanediol; sugars such as trehalose, xylitol, and sorbitol; high molecular weight compounds such as sodium hyaluronate, heparinoid, sodium chondroitin sulfate, keratin, chitin, and chitosan; lipids such as ceramide, cholesterol, and phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, and aloe extract.

[0074] Examples of vitamins include vitamin E derivatives such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate, ubiquinone derivatives and their pharmaceutically or physiologically acceptable salts, riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate, and dl-α-tocopherol nicotinate. Benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1-(4-methylphenyl)ethyl nicotinate, ascorbigen-A, stearate ascorbate, palmitate ascorbate, L-ascorbyl dipalmitate, methyl hesperidin, ergocalciferol, cholecalciferol, phylloquinone, farnoquinone, γ-oryzanol, dibenzoylthiamine, dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, Thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate, pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride, cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin, folic acid, pteroylglutamic acid, nicotinic acid, Examples include nicotinamide, pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesine, D-pantethine, coenzyme A, pantothenyl ethyl ether and other pantothenic acids, biotin, biotisine, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, carnitine, ferulic acid, alpha-lipoic acid, orotic acid, hesperidin, gamma-oryzanol, orotic acid, rutin, and eriocitrin.

[0075] Examples of cooling agents include terpenes such as camphor, 1-menthol, borneol, geraniol, cineole, anethole, limonene, and eugenol (these may be d-isomers, l-isomers, or dl-isomers); and essential oils such as eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine oil.

[0076] Examples of peptides or their derivatives include keratin-degrading peptides, hydrolyzed keratin, collagen, gelatin, elastin, elastin-degrading peptides, collagen-degrading peptides, hydrolyzed collagen, and hydrolyzed silk.

[0077] Examples of blood circulation-promoting ingredients include those derived from plants such as ginseng, angelica tree, arnica, ginkgo, laurel, watercress, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, hawthorn, juniper, cinnamon, gentian, thyme, clove, dried tangerine peel, angelica, peach kernel, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, lemon balm, yuzu, coix seed, rosemary, rosehip, peach, apricot, walnut, and corn (extracts from these plants, etc.), as well as glucosyl hesperidin.

[0078] Examples of cell-activating components include amino acids such as γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, and ε-aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids, and biotin; α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantoin, photosensitizer 301, hinokitiol, cepharanthine, and kiwi seed extract.

[0079] Astringent components include zinc paraphenolsulfonate, zinc oxide, menthol, and ethanol.

[0080] Plant extracts include: Morus alba, Saxifraga stolonifera, Perilla, Rice bran, Sake lees, White mustard, Peony, Beautyberry, Lotus seeds, Job's tears seeds, Pandanus amaryllifolius Roxb., Arcangelicia flava Merrilli, Chamomile, Coral grass, Rice leaves, Apricot fruit, Sedum sieboldii, Rose flowers, Bamboo shoot peel, Gentian, Carrot, Panax ginseng, Red ginseng, Loofah, Peach, Peach kernel, Kiwi, Sunflower, and Juazeiro (Zizyphus) Examples of plant extracts include those from joazeiro, pau d'arco, daylily, hibiscus flower, rhododendron, cherimoya, mango, red bellflower, Bletilla striata, sansho pepper peel or seed coat, safflower, Casablanca lily, guava leaf, Houttuynia cordata, pomelo, aloe fig flower, apple, white asparagus, mate tea, cherry leaf, and ylang-ylang leaf.

[0081] Examples of whitening ingredients include tocopherol, ascorbic acid, tranexamic acid, arbutin, 4-alkylresorcinol, 4-methoxysalicylic acid, hydroquinone, kojic acid, salts thereof, or derivatives thereof, placenta extract, Phellodendron amurense extract, Saxifraga stolonifera extract, and aloe extract.

[0082] Furthermore, from the viewpoint of improving the UV protection ability of this external composition, it is possible to use the aforementioned UV absorber. However, depending on the user's attributes, skin condition, and the type of UV absorber, skin irritation may be a concern. Therefore, in one embodiment of this external composition, it is preferable not to include a UV absorber. In one embodiment of this external composition, improving the dispersibility of the UV scattering agent tends to produce an excellent UV shielding effect, which can be said to suppress the need to separately incorporate a UV absorber.

[0083] Furthermore, while this external composition may also contain texture-improving agents such as microplastic beads (MPBs), silica, and alumina, it is preferable in one embodiment of the present invention that it does not contain microplastic beads, from the viewpoint of concerns about adverse effects on the ecosystem. Microplastic beads refer to solid synthetic polymers with a size of 100 μm or less. Specifically, examples include powders of nylon, acrylic acid esters, polyethylene, polystyrene, polyethylene terephthalate, polyurethane, organopolysiloxane, etc. Also, from the viewpoint of adverse effects on ecosystems, it is preferable that the embodiment of the present invention does not contain cyclopentasiloxane (D5).

[0084] Furthermore, the term "does not contain" means that it is substantially not contained. For example, in the case of ultraviolet absorbers, it means that the total content of ultraviolet absorbers is 1% by mass or less of the total amount of the topical composition, preferably 0.1% by mass or less, and most preferably 0% by mass. Similarly, in the case of microplastic beads, it means that the total content of microplastic beads is 1% by mass or less of the total amount of the topical composition, preferably 0.1% by mass or less, and most preferably 0% by mass. Furthermore, in the case of cyclopentasiloxane, this means that the total content of cyclopentasiloxane is 1% by mass or less of the total amount of the topical composition, preferably 0.1% by mass or less, and most preferably 0% by mass.

[0085] [Formulation form, etc.] This external composition can take any known form as a cosmetic, quasi-drug, or pharmaceutical. Examples include stick formulations, cream formulations, gel formulations, liniments, ointments, poultices, etc. It can also be used in the form of makeup cosmetics such as foundation, lipstick, blush, eye makeup, and face powder.

[0086] When this external composition is an oily solid external composition, it is preferably molded into a stick shape. Specifically, it is suitable for use in stick-type sunscreen formulations, stick-type whitening formulations, stick-type antiperspirant formulations, stick-type makeup cosmetics, and the like.

[0087] The term "stick-shaped" includes both those whose axial length is longer and shorter than their circumferential diameter. Furthermore, the circumferential cross-sectional shape is not particularly limited and can be a circle, ellipse, angle, irregular shape, etc. The axial end faces (top and / or bottom) may be flat, convex, or concave.

[0088] When this external composition is an oily solid external composition, its shape is not particularly limited as long as it can be applied to the application site. For example, it can be in the form of a cylindrical, elliptical, triangular, rectangular, polygonal, deformed column (petal-shaped, animal-shaped, etc.), or dome-shaped container filled with the composition.

[0089] [Application area] This external composition can be applied to the skin. Skin includes not only the surface of the body (e.g., face, head, ears, neck, chest, armpits, abdomen, waist, back, buttocks, arms, legs, hands, fingers, and genital area) but also mucous membranes.

[0090] [container] This external composition can be filled into a container of appropriate size and use, depending on the intended purpose and application. When this external composition is an oily solid external composition, the inner diameter (diameter) of the container in which the composition is filled is not particularly limited, but is preferably 3 to 100 mm, more preferably 5 to 80 mm, and particularly preferably 10 to 60 mm. The inner diameter is the shortest straight line passing through the center of gravity in the shape of the plane of the portion that comes into contact with the application area when the oily solid external composition filled in the container is removed from the container. If the solid external composition filled in the container is cylindrical, it is the diameter of the circle; if it is a square prism, it is the length of one side of the square.

[0091] When the external composition is an oily solid external composition, the depth of the container for filling the composition with the composition is not particularly limited, but is preferably 0.3 to 20, more preferably 0.8 to 12, even more preferably 1.2 to 9, even more preferably 1.4 to 6, and particularly preferably 1.6 to 3. Note that if the bottom surface of the container is not flat but has a slope or the like, the depth of the container refers to the longest distance in the depth direction.

[0092] [Characteristics of topical compositions] In one embodiment, the hardness of this external composition is, for example, 10 to 200 gf, preferably 15 to 150 gf, and more preferably 20 to 100 gf. Within this range, it can be easily and smoothly applied to the skin, resulting in a good user experience. The hardness is measured using a rheometer (product name "SUN RHEO METER CR-100", manufactured by Sun Science Co., Ltd.) after the formulation has been cooled at a constant temperature of 25°C for 12 hours or more following filling. A cylindrical adapter with a diameter of 1 mm is inserted into the center of a cylindrical container at a speed of 20 mm / min, and the maximum value measured for 30 seconds from the time of insertion is taken (unit: gf).

[0093] The viscosity of this external composition can be appropriately set depending on the dosage form, etc. In one embodiment, the viscosity (at 95°C) of this external composition is, for example, 100 to 4000 mPa·s, preferably 150 to 3000 mPa·s, and more preferably 200 to 2500 mPa·s.

[0094] The viscosity (at 95°C) mentioned above refers to the viscosity measured using a single-cylinder rotational viscometer (Brookfield type viscometer) in accordance with the viscosity measurement method described in the general test methods of the 18th edition of the Japanese Pharmacopoeia. Specifically, it refers to the value measured using the TV-10M (manufactured by Toki Sangyo Co., Ltd.), and the selection of conditions such as rotor and rotation speed shall be in accordance with the instruction manual of this instrument, and the viscosity at 95°C shall be measured. More specifically, the viscosity at 95°C shall be measured using an M3 rotor, under conditions of a rotation speed of 12 rpm and a measurement time of 60 seconds.

[0095] The following is a description of a single-cylinder rotational viscometer. A single-cylinder rotational viscometer is a viscometer that measures the torque when a cylinder in a liquid is rotated at a constant angular velocity. The viscosity η of the liquid is calculated by the following formula after experimentally determining the apparatus constant KB using a viscometer calibration standard solution. η = KB × T / ω η: Viscosity of liquid (mPa·s) KB: Equipment constant (rad / cm 3 ) ω: Angular velocity (rad / s) T: Torque acting on the cylindrical surface (10 -7 N·m)

[0096] [Manufacturing method] This external composition is manufactured by mixing each component according to conventional methods, for example, according to or in accordance with the 18th edition of the Japanese Pharmacopoeia. In the case of an oily solid external composition, for example, it is manufactured by dissolving or dispersing all components by heating, mixing, and stirring, filling into a mold, cooling, and then filling into a container.

[0097] [Method for improving the dispersibility of UV scattering agents] In one embodiment of the present invention, a method for improving the dispersibility of ultraviolet scattering agents in an external composition is also provided, which involves using in combination an ultraviolet scattering agent surface-treated with a surface treatment agent and an ultraviolet scattering agent surface-treated with a surface treatment agent of a different type than the aforementioned surface treatment agent. The details of each component in this embodiment are the same as described above.

[0098] [Other embodiments] In one embodiment of the present invention, the external composition contains an ultraviolet scattering agent (A), wherein the average particle size of the ultraviolet scattering agent (A) is 50 nm or less, and the total content of the ultraviolet scattering agent (A) is 18% by mass or more relative to the total amount of the external composition. The details of each component in this embodiment are the same as described above. [Examples]

[0099] The present invention will be described in detail below based on examples, but the present invention is not limited to these examples. The units of content shown in the examples and formulation examples are in mass%.

[0100] <Dispersion (Transparency) Evaluation Test 1> Each component shown in Table 1 was mixed in predetermined amounts to obtain a homogeneous mixture. The mixture was cooled to approximately 25°C to obtain the topical compositions for the examples and comparative examples. Two glass slides were prepared. 10 μL of each topical composition was applied to one slide, and the other slide was placed on top to sandwich the composition, thereby obtaining a test sample. A document with printed text (12-point font) was prepared, and the test sample was placed on the document. The text was observed through the area where the formulation was applied, and the dispersion state (transparency) was evaluated according to the following criteria. The results are shown in Table 1. (Evaluation Criteria) ◎...The text is easy to read. ○...I can read. △...The letters are barely legible. ×...I can't read the text.

[0101] [Table 1]

[0102] <Dispersion (Transparency) Evaluation Test 2> Each component shown in Table 2 was mixed in predetermined amounts and dissolved to obtain a homogeneous mixture. The mixture was cooled to approximately 25°C to obtain the topical compositions for the examples and comparative examples. The topical compositions were coated onto artificial leather using a barcoder, and the dispersion state (transparency) was evaluated according to the following criteria. The results are shown in Table 2. (Evaluation Criteria) ○...The coating is uniform. ×...The coating is uneven and has settled into grooves.

[0103] [Table 2]

[0104] <User experience evaluation test> Each component shown in Table 3 was mixed in predetermined amounts and dissolved while heated and stirred to obtain a homogeneous mixture. The mixture was cooled to approximately 25°C to obtain the external compositions for the examples and comparative examples.

[0105] Each topical composition was applied to the arm of five subjects, and the feel of the applied area was evaluated on a scale of 1 to 5 (integer values). Regarding stickiness and tackiness during application, each subject rated 1 point if they felt it strongly, and 5 points if they did not feel it. Furthermore, regarding the transparency of the finished surface after application, each subject rated 5 points if it was transparent, and 1 point if it was opaque and white. The average score for each topical composition was calculated and used as the evaluation value for that composition. The results are shown in Table 3. (Evaluation criteria for stickiness and squeaking) 〇…More than 3 points. ×…3 points or less. (Evaluation criteria for the transparency of the finished product) 〇…More than 3 points. ×…3 points or less.

[0106] [Table 3]

[0107] (Viscosity and hardness measurement test) The viscosity (at 95°C) was measured for Examples 9 to 14. The results were as follows: Example 9: 500 mPa·s, Example 10: 1280 mPa·s, Example 11: 230 mPa·s, Example 12: 220 mPa·s, Example 13: 990 mPa·s, and Example 14: 760 mPa·s. The viscosity measurement method is as described in this specification.

[0108] The hardness (at 25°C) was measured for Examples 9-14. The results were as follows: Example 9: 64 gf, Example 10: 98 gf, Example 11: 23 gf, Example 12: 68 gf, Example 13: 43 gf, and Example 14: 32 gf. The method for measuring hardness is as described in this specification.

[0109] The zinc oxide (ultraviolet scattering agent), titanium dioxide (ultraviolet scattering agent), and other components used in the examples and comparative examples shown in Tables 1-3 are as follows.

[0110] [UV scattering agent] *1 MICRO TITANIUM DIOXIDE MT-N1 (manufactured by Teika Co., Ltd.) *2 MTY-110M3S (manufactured by Teika Co., Ltd.) *3 MTX-05OTS (manufactured by Teika Co., Ltd.) *4 MZY-505EX (manufactured by Teika Co., Ltd.) *5 MZY-505S (manufactured by Teika Co., Ltd.) *6 MZY-508OTS (manufactured by Teika Co., Ltd.) *7 MT-01 (manufactured by Teika Co., Ltd.)

[0111] [Other ingredients] *8 LASHWAX-P (deodorizer) (manufactured by Japan Natural Products Co., Ltd.) *9 Refined microcrystalline wax (manufactured by Nikko Rica Co., Ltd.)

[0112] As a result of the above tests, as shown in Table 1, it was found that in Examples 1 to 4, which were surface-treated using different surface treatment agents with two types of ultraviolet scattering agents, the dispersion state was good and the transparency was excellent. On the other hand, Comparative Examples 1-3, which were surface-treated using the same surface treatment agent with two types of ultraviolet scattering agents, were found to have poor dispersion and inferior transparency.

[0113] Similarly, as shown in Table 2, it was found that in Examples 5-8, where two types of ultraviolet scattering agents were surface-treated using different surface treatment agents, the dispersion state was good and the transparency was excellent. On the other hand, Comparative Examples 4-6, which were surface-treated using the same surface treatment agent with two types of ultraviolet scattering agents, were found to have poor dispersion and inferior transparency.

[0114] Furthermore, as shown in Table 3, it was found that in Examples 9-14, where two types of ultraviolet scattering agents were used for surface treatment with different surface treatment agents, there was no stickiness, the finish after application was transparent, and the usability was excellent. On the other hand, Comparative Examples 7-9, which were surface-treated using the same surface treatment agent with two types of ultraviolet scattering agents, were found to be sticky, lacked transparency in the finished product after application, and were inferior in terms of usability.

[0115] Based on the above results, it has become clear that a topical composition containing an ultraviolet scattering agent, specifically one that includes an ultraviolet scattering agent surface-treated with a surface treatment agent and another ultraviolet scattering agent surface-treated with a surface treatment agent of a different type, exhibits superior usability and transparency.

[0116] Examples of formulations of the present invention are shown below.

[0117] <Formulation Example 1: UV Stick Formulation> Titanium dioxide (surface treated with fatty acid components) 15% by mass Zinc oxide (surface treated with triethoxycaprylylsilane) 15% by mass Paraffin wax 15% by mass Microcrystalline wax 5% by mass Triethylhexanoin 22.98% by mass Caprylic / Capric Triglyceride 15% by mass Isopropyl isostearate 10% by mass Vitamin E derivative 0.5% by mass Sodium hyaluronate 0.01% by mass Ascorbic acid derivative 0.5% by mass Ceramides 0.01% by mass 1,2-Hexanediol 1% by mass Total 100% by mass

[0118] <Example of formulation 2: Makeup base stick> Zinc oxide (fluorine-based surface treatment) 10% by mass Titanium dioxide (surface treated with silicone component) 15% by mass Polyethylene wax 10% by mass Rice bran wax 8% by mass Glyceryl triisostearate 15% by mass Caprylic / Capric Triglyceride 19.098% by mass Hydrogenated polyisobutene 15% by mass Mica 0.05% by mass Synthetic fluorophlogopite 0.7% by mass Tin oxide 0.1% by mass Vitamin E derivative 0.5% by mass Sodium hyaluronate 0.001% by mass Ascorbic acid derivative 0.05% by mass Ceramides 0.001% by mass 1,2-Hexanediol 1% by mass Polyglyceryl-2 Triisostearate 5% by mass Red 202 0.2% by mass Blue 1 0.1% by mass Yellow 4 0.2% by mass Total 100% by mass

[0119] <Example of formulation 3: Stick-type foundation> Zinc oxide (surface treated with alkyl titanate) 12% by mass Titanium dioxide (surface treated with silane compound) 18% by mass Beeswax 15% by mass Carnauba wax 8% by mass Synthetic wax 6% by mass Squalane 10% by mass Polyglyceryl-2 triisostearate 10.29% by mass 1,2-Hexanediol 2% by mass Arbutin 2% by mass Vitamin E derivative 0.5% by mass Sodium hyaluronate 0.2% by mass Ascorbic acid derivative 0.2% by mass Ceramides 0.2% by mass Hydrolyzed collagen 0.01% by mass Synthetic fluorophlogopite 0.7% by mass Tin oxide 0.3% by mass Titanium dioxide 0.1% by mass Calcium Al borosilicate 1% by mass Silica 4% by mass Titanium dioxide (pigment) 8.5% by mass Iron oxide 1% by mass Total 100% by mass

Claims

1. A topical composition containing an ultraviolet scattering agent (A), The ultraviolet scattering agent (A) is an external composition comprising an ultraviolet scattering agent (A1) whose surface has been treated with a surface treatment agent and an ultraviolet scattering agent (A2) whose surface has been treated with a surface treatment agent of a different type than the aforementioned surface treatment agent.

2. The topical composition according to claim 1, wherein the surface treatment agent comprises one or more selected from the group consisting of fatty acid components, silicone components, and silane compounds.

3. The topical composition according to claim 1 or 2, wherein the ultraviolet scattering agent (A1) is titanium dioxide surface-treated with a surface treatment agent, and the ultraviolet scattering agent (A2) is zinc oxide surface-treated with a surface treatment agent.

4. The topical composition according to claim 1 or 2, wherein the ultraviolet scattering agent (A1) is titanium dioxide surface-treated with a surface treatment agent containing a fatty acid component, and the ultraviolet scattering agent (A2) is zinc oxide surface-treated with a surface treatment agent containing a silane compound.

5. The topical composition according to claim 4, wherein the mass ratio (A1 / A2) of the ultraviolet scattering agent (A1) to the ultraviolet scattering agent (A2) is 5 / 95 to 50 / 50.

6. The topical composition according to claim 1 or 2, wherein the average particle size of the ultraviolet scattering agent (A) is 50 nm or less.

7. The topical composition according to claim 1 or 2, wherein the total content of the ultraviolet scattering agent (A) is 18% by mass or more relative to the total amount of the topical composition.

8. Furthermore, the topical composition according to claim 1 or 2 further contains a liquid polar oil and a solid wax.

9. The topical composition according to claim 1 or 2, which does not contain an ultraviolet absorber.

10. The topical composition according to claim 8, wherein the viscosity of the topical composition at 95°C is 100 to 4000 mPa·s.

11. The topical composition according to claim 8, wherein the hardness of the topical composition at 25°C is 10 to 200 gf.

12. The topical composition according to claim 8, wherein the topical composition is a solid topical composition.

13. The topical composition according to claim 8, wherein the topical composition is in the form of a stick.

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