Flavonoid composition and its use

Abstract

This disclosure relates to the field of flavors or cosmetics. More specifically, the present invention relates to liquid compositions comprising a compound of formula (I) and / or a compound of formula (II), a carvone-containing oil, and optionally a solvent. The disclosure further relates to the use of such compositions in consumer products such as flavored products and body care products.

Description

[Technical Field]

[0001] Cross-reference of related applications This application claims the benefit of priority from U.S. Provisional Application No. 63 / 381,254 filed on 27 October 2022 and European Application No. 23156674.6 filed on 15 February 2023, both of which are incorporated herein by reference as if they were included herein.

[0002] This disclosure relates to the field of flavors or cosmetics. More specifically, the present invention relates to liquid compositions comprising a compound of formula (I) and / or a compound of formula (II), a carvone-containing oil, and optionally a solvent. The disclosure further relates to the use of such compositions in consumer products, such as flavored products and body care products, to give some examples.

[0003] Background technology Sensory information about the chemical composition of the external environment can be provided by taste and sensory systems found throughout the animal kingdom, from simple metazoans to the most complex vertebrates. Such sensory information can include not only tastes such as sweetness, but also sensations of coldness.

[0004] Menthol modulates TRPM8 receptors in a way that produces a cooling sensation in the mouth. Therefore, natural products containing menthol, such as mint extracts, tend to provide a cooling effect in the mouth. For this same reason, menthol is often used as an ingredient in non-extracted caries flavorings where a cooling effect is desired. However, menthol can have a bitter or astringent taste, which some users may find objectionable.

[0005] Certain synthetic compounds known as cooling-enhancing compounds can be used to enhance the cooling effect of menthol, allowing for a decrease in menthol concentration and the resulting reduction of undesirable astringency or bitterness. Due to the potency of these cooling-enhancing compounds, they are typically diluted in solvents, particularly those approved for use in consumer products for application to mucous membranes or skin. However, such compounds are solids with low solubility in the most common flavor and cosmetic solvents at room temperature and atmospheric pressure.

[0006] Sweetness is the most commonly perceived taste when consuming foods rich in sugars. Caloric sweeteners such as sucrose and fructose are archetypal examples of sweetening substances. Caloric sweeteners are a significant contributing factor to the prevalence of metabolic disorders and related conditions such as obesity, diabetes, and cardiovascular disease. While various calorie-free and low-calorie alternatives exist, many consumers do not perceive them as suitable substitutes, as they are merely present in foods or beverages, for example. Many such consumers may perceive unpleasant off-flavors, including astringency, bitterness, and metallic and licorice-like tastes.

[0007] Similar to the cooling approach, flavor-modifying compounds, such as sweetness-enhancing compounds, can be used to offer alternative approaches to overcome some of the adoption challenges faced by low-calorie sweeteners. Such compounds can be used in combination with sucrose or fructose to enhance sweetness, thereby enabling the use of smaller amounts of such calorie sweeteners in a variety of food or beverage products. However, like cooling-enhancing compounds, some sweetness-enhancing compounds are solids that are difficult to handle and incorporate into consumer products because they have low solubility in the most common flavor and cosmetic solvents and are too potent to be used in undiluted form.

[0008] Therefore, there is a continuous need for solvents suitable for solubilizing the above-mentioned types of sensory-enhancing compounds in order to provide these compounds in more convenient diluted forms.

[0009] Summary of the Invention The following aspects of the present disclosure are intended to address one or more of the above problems.

[0010] In a first aspect, the present disclosure provides a) a compound of formula (I) [Chemical formula] or a salt thereof, wherein R 1 is a hydrogen atom, -OH or -O-R 1A ; R 1A is C 1~6 alkyl which may be substituted one or more times by a substituent selected from the group consisting of -OH and C 1~6 alkoxy; or R 1A is an oligosaccharide moiety having 2 to 5 sugar moieties independently selected from the group consisting of a glucuronyl moiety, a furanose moiety, a pyranose moiety, or attached by a glycosidic bond; R 2 is a hydrogen atom, -OH or -O-R 2A ; R 2A is C 1~6 alkyl which may be substituted one or more times by a substituent selected from the group consisting of -OH and C 1~6 alkoxy, or R 2A is an oligosaccharide moiety having 2 to 5 sugar moieties independently selected from the group consisting of a glucuronyl moiety, a furanose moiety, a pyranose moiety, or attached by a glycosidic bond; R 3 is -OH or -O-R 3A ; R 3A is C 1~6 alkyl which may be substituted one or more times by a substituent selected from the group consisting of -OH and C 1~6 alkoxy; or R 3AThis is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 4 is a hydrogen atom, -OH or -OR 4A and; R 4A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 4A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 5 These are hydrogen atoms, -OH, and -OR 5A or -OC(O)-R 5B and; R 5A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 5A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 5B is -H, or -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; R 6 and R 7 C 1~6 alkyl, -OH, C 1~6 Alkoxy and -O-(C 1~6 Alkylene)-O-(C 1~6 Selected from the group consisting of alkyls; m is 0, 1 or 2; and n is 0, 1, 2, or 3; or Compound of formula (II) [ka] or its salt, in the formula, R 8 is a hydrogen atom, -OH or -OR 8A and; R 8A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 8A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 9 is a hydrogen atom, -OH or -OR 9A and; R 9A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 Alkyl or R 9A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 10 is -OH or -OR 10A and; R 10A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 10AThis is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 11 is a hydrogen atom, -OH or -OR 11A and; R 11A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 11A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 12 These are hydrogen atoms, -OH, and -OR 12A or -OC(O)-R 12B and; R 12A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 12A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 12B is -H, or -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; R 13 and R 14 C 1~6 alkyl, -OH, C 1~6 Alkoxy and -O-(C 1~6 Alkylene)-O-(C 1~6 Selected from the group consisting of alkyls; m' is 0, 1 or 2; and n' is 0, 1, 2, or 3; or a combination thereof; b) Oils containing carbonone; and c) Optionally, solvent This relates to a liquid composition containing [a specific substance].

[0011] In a second aspect, the disclosure relates to a consumer product comprising a liquid composition described herein.

[0012] Modes for carrying out the invention The following detailed description outlines various aspects and embodiments provided herein. The description should be read from the perspective of those skilled in the art; therefore, it does not necessarily include information that is well known to such people. It will be apparent to those skilled in the art that the various aspects and embodiments provided herein can be combined in any way without departing from the spirit of this disclosure.

[0013] The following terms and phrases have the meanings set forth below unless otherwise specified herein. This disclosure may use other terms and phrases not expressly defined herein. Such other terms and phrases will have the meanings they would have to a person skilled in the art within the context of this disclosure. In some cases, a term or phrase may be defined in the singular or plural form. In such cases, it is understood that any singular term may include its plural counterpart and vice versa, unless expressly indicated otherwise. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as generally understood to a person skilled in the art with whom this disclosure relates.

[0014] As used herein, the terms "a," "an," or "the" mean "one or more" or "at least one," unless otherwise specified.

[0015] Compositions and methods are described using the terms “comprising,” “containing,” or “including” various components or processes, but compositions and methods may also “consist essentially of” or “consist of” various components, substances, and processes. As used herein, the term “consist essentially of” shall be interpreted as including additional components, substances, or processes that do not materially affect the basic and novel properties of the enumerated components, substances, or processes, and of the composition or method. In some embodiments, compositions according to embodiments of this disclosure that “consist essentially of” the enumerated components or substances do not include additional components or substances that alter the basic and novel properties of the composition.

[0016] It should be understood that any numerical range enumerated herein is intended to include all subranges contained therein. For example, the range "1 to 10" is intended to include all subranges between and including the enumerated minimum value of 1 and the enumerated maximum value of 10, i.e., all subranges having a minimum value of 1 or greater and a maximum value of 10 or less. Since the disclosed numerical ranges are continuous, they include all values ​​between the minimum and maximum values. Unless otherwise specified, the various numerical ranges specified in this application are approximations.

[0017] As used herein, the terms “about” or “approximately” mean, unless otherwise indicated, an acceptable error of a particular value as determined by those skilled in the art, which depends in part on how the value is measured or determined. In certain embodiments, the terms “about” or “approximately” mean within 1, 2, 3 or 4 standard deviations. In certain embodiments, the terms “about” or “approximately” mean within 50%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5% or 0.05% of a given value or range.

[0018] Throughout this disclosure, various publications may be incorporated by reference. If the meaning of any wording in such incorporated publications conflicts with the meaning of the wording in this disclosure, the meaning of the wording in this disclosure shall prevail unless otherwise indicated.

[0019] As used herein, “solvate” means a compound formed by the interaction of one or more solvent molecules with one or more compounds described herein. In some embodiments, the solvate is an adoptably acceptable solvate, such as a hydrate.

[0020] When used herein, "C a ~C b " or "C a~b "C1-C4 alkyl" (where "a" and "b" are integers) refers to the number of carbon atoms in a particular group. That is, a group can contain carbon atoms between "a" and "b". Therefore, for example, "C1-C4 alkyl" or "C 1~4 The "alkyl" group refers to all alkyl groups having 1 to 4 carbon atoms, namely CH3-, CH3CH2-, CH3CH2CH2-, (CH3)2CH-, CH3CH2CH2CH2-, CH3CH2CH(CH3)-, and (CH3)3C-.

[0021] As used herein, “halogen” or “halo” means any one of the radiostable atoms in column 7 of the periodic table, such as fluorine, chlorine, bromine, or iodine. In some embodiments, “halogen” or “halo” refers to fluorine or chlorine.

[0022] As used herein, “alkyl” means a fully saturated straight or branched hydrocarbon chain (i.e., without double or triple bonds). In some embodiments, the alkyl group has 1 to 20 carbon atoms (wherever it appears herein, a numerical range such as “1 to 20” refers to each integer within a given range; for example, “1 to 20 carbon atoms” means that the alkyl group may consist of 20 or fewer carbon atoms, such as 1 carbon atom, 2 carbon atoms, 3 carbon atoms, etc., but this definition also includes appearances of the term “alkyl” where no numerical range is specified). The alkyl group may also be a medium-sized alkyl group having 1 to 9 carbon atoms. Furthermore, the alkyl group may be a lower alkyl group having 1 to 4 carbon atoms. 1~4 It may be designated as "alkyl" or a similar name. Just as an example, "C 1~4 The term "alkyl" indicates that the alkyl chain has 1 to 4 carbon atoms, meaning the alkyl chain is selected from the group consisting of methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl, and t-butyl. Typical alkyl groups include, but are by no means limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, and hexyl. Unless otherwise indicated, the term "alkyl" refers to an unsubstituted group.

[0023] As used herein, "substituted alkyl" means C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 heteroalkyl, C3-C7 carbocyryl (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 3-10 membered heterocyclyl (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), aryl (halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloal C1-C6 haloalkoxy(C1-C6)(may be substituted with C1-C6 haloalkoxy), 5-10 member heteroaryl(C1-C6) (may be substituted with alkyl and C1-C6 haloalkoxy), 3-10 member heterocyclyloxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 5-10 member heteroaryloxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), C3-C7-carbocykyl-C1-C6-alkoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy) (may be substituted with alkyl and C1-C6 haloalkoxy), 3-10 member heterocyclyl-C1-C6-alkoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), aryl(C1-C6)alkoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 5-10 member heteroaryl(C1-C6)alkoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy,(may be substituted with C1-C6 haloalkyl and C1-C6 haloalkoxy), sulfhydryl (mercapto), halo(C1-C6)alkyl (e.g., -CF3), halo(C1-C6)alkoxy (e.g., -OCF3), C1-C6 alkylthio, arylthio (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), C3-C7 carbocyclylthio (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl (and may be substituted with C1-C6 haloalkoxy), 3-10 member heterocyclylthio (halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy, 5-10 member heteroarylthio (halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy, C3-C7-carbocykyl-C1-C6-alkylthio (halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C 6-haloalkyl and C1-C6 haloalkoxy (may be substituted), 3-10 member heterocyclyl-C1-C6-alkylthio (halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy, aryl(C1-C6)alkylthio (halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy, 5-10 member heteroaryl(C1-C6)alkylthio (halo, C1-C This refers to alkyl groups substituted with one or more substituents independently selected from 6-alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, and C1-C6 haloalkoxy (which may be substituted with amino, nitro, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amide, N-amide, S-sulfonamide, N-sulfonamide, C-carboxy, O-carboxy, acyl, cyanato, isocyanato, thiocyanato, isothiocyanato, sulfinyl, sulfonyl, and oxo (=O).

[0024] As used herein, "alkoxy" means a -OR moiety, wherein R is alkyl as defined above such as, but not limited to, methoxy, ethoxy, n-propoxy, 1-methylethoxy (isopropoxy), n-butoxy, iso-butoxy, sec-butoxy, and tert-butoxy, "C 1~9 alkoxy" is alkyl as defined above.

[0025] As used herein, "alkylthio" means a -SR moiety, wherein R is alkyl as defined above such as, but not limited to, methylmercapto, ethylmercapto, n-propylmercapto, 1-methylethylmercapto (isopropylmercapto), n-butylmercapto, iso-butylmercapto, sec-butylmercapto, tert-butylmercapto, "C 1~9 alkylthio" is alkyl as defined above.

[0026] As used herein, "alkenyl" means a straight-chain or branched hydrocarbon chain containing one or more double bonds. In some embodiments, the alkenyl group has 2 to 20 carbon atoms, but this definition also encompasses occurrences of the term "alkenyl" where no numerical range is specified. Also, the alkenyl group may be a medium-sized alkenyl having 2 to 9 carbon atoms. Also, the alkenyl group may be a lower alkenyl having 2 to 4 carbon atoms. The alkenyl group may be designated as "C 2~4 alkenyl" or a similar name. By way of mere example, "C 2~4The term "alkenyl" indicates that an alkenyl chain contains 2 to 4 carbon atoms; that is, alkenyl chains are selected from the group consisting of ethenyl, propen-1-yl, propen-2-yl, propen-3-yl, buten-1-yl, buten-2-yl, buten-3-yl, buten-4-yl, 1-methyl-propen-1-yl, 2-methyl-propen-1-yl, 1-ethyl-ethen-1-yl, 2-methyl-propen-3-yl, buta-1,3-dienyl, buta-1,2-dienyl, and buta-1,2-dien-4-yl. Typical alkenyl groups include, but are by no means limited to, ethenyl, propenyl, butenyl, pentenyl, and hexenyl. Unless otherwise indicated, the term "alkenyl" refers to an unsubstituted group.

[0027] As used herein, “alkynyl” means a straight or branched hydrocarbon chain containing one or more triple bonds. In some embodiments, the alkynyl group has 2 to 20 carbon atoms, but this definition also includes occurrences of the term “alkynyl” where a numerical range is not specified. The alkynyl group may also be a medium-sized alkynyl having 2 to 9 carbon atoms. The alkynyl group may also be a lower alkynyl having 2 to 4 carbon atoms. The alkynyl group is “C 2~4 It may be designated as "Alkinyl" or a similar name. Just as an example, "C 2~4 The term "alkynyl" indicates that the alkynyl chain has 2 to 4 carbon atoms, meaning the alkynyl chain is selected from the group consisting of ethynyl, propyne-1-yl, propyne-2-yl, butyne-1-yl, butyne-3-yl, butyne-4-yl, and 2-butynyl. Typical alkynyl groups include, but are by no means limited to, ethynyl, propynyl, butynyl, pentynyl, and hexynyl. Unless otherwise indicated, the term "alkynyl" refers to an unsubstituted group.

[0028] As used herein, “heteroalkyl” means a straight or branched hydrocarbon chain whose chain skeleton contains one or more heteroatoms, i.e., elements other than carbon, including but not limited to nitrogen, oxygen, and sulfur. In some embodiments, a heteroalkyl group has 1 to 20 carbon atoms, but this definition also includes occurrences of the term “heteroalkyl” where a numerical range is not specified. Furthermore, a heteroalkyl group may be a medium-sized heteroalkyl group having 1 to 9 carbon atoms. Furthermore, a heteroalkyl group may be a lower heteroalkyl group having 1 to 4 carbon atoms. 1~4 It may be designated as "heteroalkyl" or a similar name. A heteroalkyl group may contain one or more heteroatoms. Just as an example, "C 1~4 The term "heteroalkyl" indicates that the heteroalkyl chain contains 1 to 4 carbon atoms, and that the chain's backbone contains one or more heteroatoms. Unless otherwise indicated, the term "heteroalkyl" refers to an unsubstituted group.

[0029] As used herein, “alkylene” means a branched or linear fully saturated diradical chemical group containing only carbon and hydrogen, bonded to the rest of the molecule via two bonding sites (i.e., alkanediyl). In some embodiments, the alkylene group has 1 to 20 carbon atoms, but this definition also includes occurrences of the term alkylene where a numerical range is not specified. Furthermore, the alkylene group may be a medium-sized alkylene having 1 to 9 carbon atoms. Also, the alkylene group may be a lower alkylene having 1 to 4 carbon atoms. The alkylene group is “C 1~4 It may be designated as "alkylene" or a similar name. Just as an example, "C 1~4"Alkylene" means that there are 1 to 4 carbon atoms in the alkylene chain, that is, the alkylene chain is selected from the group consisting of methylene, ethylene, ethane-1,1-diyl, propylene, propane-1,1-diyl, propane-2,2-diyl, 1-methyl-ethylene, butylene, butane-1,1-diyl, butane-2,2-diyl, 2-methyl-propane-1,1-diyl, 1-methyl-propylene, 2-methyl-propylene, 1,1-dimethyl-ethylene, 1,2-dimethyl-ethylene and 1-ethyl-ethylene. Unless otherwise indicated, the term "alkylene" refers to an unsubstituted group.

[0030] As used herein, "alkenylene" means a straight-chain or branched diradical chemical group that contains only carbon and hydrogen and contains at least one carbon-carbon double bond bonded to the rest of the molecule through two bonding points. In some embodiments, the alkenylene group has 2 to 20 carbon atoms, but this definition also encompasses the occurrence of the term alkenylene where no numerical range is specified. Also, the alkenylene group may be a medium-sized alkenylene having 2 to 9 carbon atoms. Also, the alkenylene group may be a lower alkenylene having 2 to 4 carbon atoms. The alkenylene group may be designated as "C 2~4 alkenylene" or a similar name. By way of example only, "C 2~4"Alkenylene" refers to an alkenylene chain having 2 to 4 carbon atoms. That is, an alkenylene chain can be ethenylene, ethene-1,1-diyl, propenylene, propene-1,1-diyl, propane-2-ene-1,1-diyl, 1-methylethenylene, buta-1-enylene, buta-2-enylene, buta-1,3-dienylene, buten-1,1-diyl, buta-1,3-diene-1,1-diyl, buta-2-ene-1,1-di This indicates that the group is selected from the group consisting of yl, buta-3-en-1,1-diyl, 1-methyl-propa-2-en-1,1-diyl, 2-methyl-propa-2-en-1,1-diyl, 1-ethyl-ethenylene, 1,2-dimethyl-ethenylene, 1-methyl-propenylene, 2-methyl-propenylene, 3-methyl-propenylene, 2-methyl-propen-1,1-diyl, and 2,2-dimethyl-ethen-1,1-diyl. Unless otherwise indicated, the term "alkenylene" refers to the group that is not further substituted.

[0031] As used herein, “aromatic” means a ring or ring system having a conjugated π-electron system, and includes both carbocyclic aromatic groups (e.g., phenyl) and heterocyclic aromatic groups (e.g., pyridine). The term includes monocyclic or fused polycyclic (i.e., rings sharing adjacent pairs of atoms) groups, provided that the entire ring system is aromatic.

[0032] As used herein, “aryl” means an aromatic ring or ring system (i.e., two or more fused rings sharing two adjacent carbon atoms) whose ring skeleton consists solely of carbon atoms. If the aryl is a ring system, all rings in the system are aromatic. In some embodiments, the aryl group has 6 to 18 carbon atoms, but this definition also includes occurrences of the term “aryl” where no numerical range is specified. In some embodiments, the aryl group has 6 to 10 carbon atoms. The aryl group is “C 6~10 "Aryl", "C6~C 10It may be designated as “aryl” or a similar name. Examples of aryl groups include, but are not limited to, phenyl, naphthyl, azlenyl, and anthracenyl. In some embodiments, the term “aryl” refers to phenyl. Unless otherwise indicated, the term “aryl” refers to an unsubstituted group.

[0033] As used herein, "aryloxy" and "arylthio" refer to the RO- and RS- portions of the formula, respectively, where R is a compound of phenyloxy and phenylthio, and is not limited to these. 6~10 "aryloxy" or "C 6~10 This refers to aryls as defined above, such as "arylthio".

[0034] As used herein, "aralkyl" or "arylalkyl" means "C 7~14 This refers to an aryl group bonded as a substituent via an alkylene group such as "aralkyl," and includes, but is not limited to, benzyl, 2-phenylethyl, and 3-phenylpropyl. In some embodiments, the alkylene group is a lower alkylene group (i.e., C 1~4 (Alkylene group)

[0035] As used herein, “heteroaryl” means an aromatic ring or ring system (i.e., two or more fused rings sharing two adjacent atoms) whose ring skeleton contains one or more heteroatoms, i.e., elements other than carbon, including but not limited to nitrogen, oxygen, and sulfur. If the heteroaryl is a ring system, all rings in the system are aromatic. In some embodiments, the heteroaryl group has 5 to 18 ring members (i.e., the number of atoms constituting the ring skeleton, including carbon atoms and heteroatoms), but this definition also includes occurrences of the term “heteroaryl” where a numerical range is not specified. In some embodiments, the heteroaryl group has 5 to 10 ring members or 5 to 7 ring members. The heteroaryl group may be referred to as a “5-7 membered heteroaryl,” a “5-10 membered heteroaryl,” or similar names. Examples of heteroaryl rings include, but are not limited to, furyl, thienyl, phthalazinyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, triazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolyl, and benzothienyl. Unless otherwise indicated, the term "heteroaryl" refers to the group that is not further substituted.

[0036] As used herein, “heteroaralkyl” or “heteroarylalkyl” means a heteroaryl group bonded as a substituent via an alkylene group. Examples include, but are not limited to, 2-thienylmethyl, 3-thienylmethyl, furylmethyl, thienylethyl, pyrrolylalkyl, pyridylalkyl, isoxazolylalkyl, and imidazolylalkyl. In some cases, the alkylene group may be a lower alkylene group (i.e., C 1~4 (Alkylene group)

[0037] As used herein, “carbocyclyl” means a non-aromatic cyclic ring or cyclic system containing only carbon atoms in its cyclic framework. If a carbocyclyl is a cyclic system, two or more rings may be bonded together by condensation, bridging, or spirobonding. A carbocyclyl can have any degree of saturation, provided that at least one ring in the cyclic system is non-aromatic. Therefore, carbocyclyls include cycloalkyls, cycloalkenyls, and cycloalkynyls. In some embodiments, the carbocyclyl group has 3 to 20 carbon atoms, but this definition also includes instances where the term “carbocyclyl” does not specify a numerical range. Furthermore, the carbocyclyl group may be a medium-sized carbocyclyl having 3 to 10 carbon atoms. Also, the carbocyclyl group may be a carbocyclyl having 3 to 6 carbon atoms. The carbocyclyl group is “C 3~6 It may be designated as “carbocykrill” or a similar name. Examples of carbocyclyl rings include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, 2,3-dihydroindene, bicyclo[2.2.2]octanyl, adamantyl, and spiro[4.4]nonanyl. Unless otherwise indicated, the term “carbocykrill” refers to the group that is not further substituted.

[0038] As used herein, "(carbocycryl)alkyl" means "C 4~10 This refers to a carbocyclyl group bonded as a substituent via an alkylene group such as "(carbocyclyl)alkyl," and includes, but is not limited to, cyclopropylmethyl, cyclobutylmethyl, cyclopropylethyl, cyclopropylbutyl, cyclobutylethyl, cyclopropylisopropyl, cyclopentylmethyl, cyclopentylethyl, cyclohexylmethyl, cyclohexylethyl, and cycloheptylmethyl. In some cases, the alkylene group is a lower alkylene group.

[0039] As used herein, "cycloalkyl" means a fully saturated carbocyclyl ring or ring system according to any of the embodiments described above for carbocyclyl. Examples include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.

[0040] As used herein, "cycloalkenyl" means a carbocyclyl ring or ring system having at least one double bond, wherein the ring in the ring system is not aromatic and is as described above for carbocyclyl. One example is cyclohexenyl.

[0041] As used herein, “heterocyclyl” means a non-aromatic cyclic ring or ring system containing at least one heteroatom in its ring skeleton. Heterocyclyls may be joined together by condensation, bridging, or spirobonding. Heterocyclyls may have any degree of saturation, provided that at least one ring in the ring system is non-aromatic. The heteroatom may be present in either the non-aromatic or aromatic ring of the ring system. In some embodiments, a heterocyclyl group has 3 to 20 ring members (i.e., the number of atoms constituting the ring skeleton, including carbon atoms and heteroatoms), but this definition also includes occurrences of the term “heterocyclyl” without a specified numerical range. A heterocyclyl group may also be a medium-sized heterocyclyl having 3 to 10 ring members. A heterocyclyl group may also be a heterocyclyl having 3 to 6 ring members. A heterocyclyl group may be designated as a “3-6 membered heterocyclyl” or similar designation. In a preferred six-membered monocyclic heterocycline, the heteroatoms are selected from one to three O, N, or S atoms, and in a preferred five-membered monocyclic heterocycline, the heteroatoms are selected from one or two heteroatoms selected from O, N, or S atoms.Examples of heterocyclyl rings include azepinyl, acridinyl, carbazolyl, cinnolinyl, dioxolanil, imidazolinyl, imidazolidinyl, morpholinil, oxylanil, oxepanil, thiepanil, piperidinyl, piperazinyl, dioxopiperazinyl, pyrrolidinyl, pyrrolidonyl, pyrrolidionyl, 4-piperidonyl, pyrazolinyl, pyrazolidinyl, 1,3-dioxynyl, 1,3-dioxanyl, 1,4-dioxynyl, 1,4-dioxanyl, 1,3-oxathianyl, 1,4-oxathianyl, 1,4-oxathianyl, 2H-1,2-oxazinyl, trioxanyl, hexahydro-1, Examples include, but are not limited to, 3,5-triazinyl, 1,3-dioxolyl, 1,3-dioxolanil, 1,3-dithiolyl, 1,3-dithiolanil, isoxazolinyl, isoxazolidinyl, oxazolinyl, oxazolidinyl, oxazolidinyl, thiazolinyl, thiazolidinyl, 1,3-oxathiolanil, indolinyl, isoindolinyl, tetrahydrofuranil, tetrahydropyranil, tetrahydrothiophenyl, tetrahydrothiopyranil, tetrahydro-1,4-thiadinyl, thiamorpholinil, dihydrobenzofuranil, benzimidazolidinyl, and tetrahydroquinoline.

[0042] As used herein, "(heterocyclyl)alkyl" means a heterocyclyl group bonded as a substituent via an alkylene group. Examples include, but are not limited to, imidazolinylmethyl and indolinylethyl.

[0043] The "acyl" group refers to -C(=O)R, where R is hydrogen, C as defined herein. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 These include aryls, 5- to 10-membered heteroaryls, and 3- to 10-membered heterocyclines. Non-limiting examples include formyl, acetyl, propanoyl, benzoyl, and acrylic.

[0044] The "O-carboxyl" group refers to the "-OC(=O)R" group, where R is hydrogen, C as defined herein. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0045] The "C-carboxyl" group refers to the "-C(=O)OR" group, where R is hydrogen, C as defined herein. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The compounds are selected from aryls, 5- to 10-membered heteroaryls, and 3- to 10-membered heterocyclines. Non-restrictive examples include carboxyls (i.e., -C(=O)OH).

[0046] The "cyano" group refers to the "-CN" group.

[0047] The "cyanato" group refers to the "-OCN" group.

[0048] The "isocyanato" group refers to the "-NCO" group.

[0049] The "thiocyanate" group refers to the "-SCN" group.

[0050] The "isothiocyanate" group refers to the "-NCS" group.

[0051] The "sulfinyl" group refers to the "-S(=O)R" group, where R is hydrogen, C as defined herein. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0052] The "sulfonyl" group refers to the "-SO2R" group, where R is hydrogen, C as defined herein. 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0053] The "S-sulfonamide" group is "-SO2NR A R B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0054] The "N-sulfonamide" group is "-N(R A )SO2R B " refers to the base, and in the formula, R A and R b Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0055] The "O-carbamyl" group is "-OC(=O)NR" A R B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0056] The "N-carbamyl" group is "-N(R A )C(=O)OR B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0057] The "O-thiocarbamyl" group is "-OC(=S)NR" A R B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0058] The "N-thiocarbamyl" group is "-N(R A )C(=S)OR B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0059] The "C-amide" group is "-C(=O)NRA R B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0060] The "N-amide" group is "-N(R A )C(=O)R B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The selection is made from aryls, 5-10 membered heteroaryls, and 3-10 membered heterocyclines.

[0061] The "amino" group is "-NR A R B " refers to the base, and in the formula, R A and R B Each of these, independently, is defined herein as hydrogen, C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~7 Carbocyclyl, C 6~10 The compounds are selected from aryls, 5- to 10-membered heteroaryls, and 3- to 10-membered heterocyclines. A non-limiting example is free aminos (i.e., -NH2).

[0062] The "aminoalkyl" group refers to an amino group bonded via an alkylene group.

[0063] The "alkoxyalkyl" group is "C 2~8This refers to an alkoxy group bonded via an alkylene group, such as an "alkoxyalkyl group."

[0064] As used herein, “glucosyl moiety” refers to a monovalent moiety in which one of the hydroxyl groups of glucose is replaced by a bond to another atom, functional group, or moiety. Unless otherwise specified, glucose can have any suitable stereochemistry. Thus, this term includes moieties having D stereochemistry, as well as moieties having L stereochemistry. Furthermore, this term includes moieties having α stereochemistry, as well as moieties having β stereochemistry. The carbon atoms of the glucosyl moiety follow conventional numbering, as shown below. The diagram is shown for β-D glucose, but applies similarly to glucosyl moieties having α and / or L stereochemistry. [ka]

[0065] As used herein, “glucuronyl moiety” refers to a monovalent moiety in which one of the hydroxyl groups of glucuronic acid is replaced by a bond to another atom, functional group, or moiety. Unless otherwise specified, glucuronic acid can have any suitable stereochemistry. Thus, this term includes moieties having D stereochemistry, as well as moieties having L stereochemistry. Furthermore, this term includes moieties having α stereochemistry, as well as moieties having β stereochemistry. The carbon atoms of the glucuronyl moiety follow conventional numbering, as shown below. The diagram is shown for β-D glucuronic acid, but applies similarly to glucuronyl moieties having α and / or L stereochemistry. [ka]

[0066] The term “C 1~6 The alkylglucuronyl ester portion is formed when the carboxylic acid group of glucuronic acid has a hydrogen atom replaced by a C atom. 1~6This refers to a glucuronyl moiety (as defined in this paragraph) having an alkyl group. In any of the following embodiments, C 1~6 The alkyl portion can have any suitable value such as methyl, ethyl, isopropyl, propyl, butyl, or pentyl. In some embodiments, C 1~6 The alkyl portion is methyl. In some other embodiments, C 1~6 The alkyl portion is ethyl.

[0067] As used herein, substituents are derived from an unsubstituted parent group in which one or more hydrogen atoms are exchanged with another atom or group. Unless otherwise indicated, when a group is considered "substituted", that group is a C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 heteroalkyl, C3-C7 carbocyrill (which may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), C3-C7-carbocyrill-C1-C6-alkyl (which may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy). (may be substituted with), 3-10 member heterocyclyl (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 3-10 member heterocyclyl-C1-C6-alkyl (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), aryl (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy) a) aryl(C1~C6)alkyl (may be substituted with halo, C1~C6alkyl, C1~C6alkoxy, C1~C6 haloalkyl and C1~C6 haloalkoxy), 5~10 member heteroaryl (may be substituted with halo, C1~C6alkyl, C1~C6alkoxy, C1~C6 haloalkyl and C1~C6 haloalkoxy), 5~10 member heteroaryl(C1~C6)alkyl (may be substituted with halo, C1~C6alkyl, C1~C6alkoxy, C1~C6 haloalkyl and C1~C6 haloalkoxy) (may be substituted with), halo, cyano, hydroxy, C1-C6 alkoxy, C1-C6 alkoxy(C1-C6) alkyl (i.e., ether), aryloxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), C3-C7 carbocykryloxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 3-10 member heterocyclyloxy (halo,(may be substituted with C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 5-10 member heteroaryl-oxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), C3-C7-carbocykryl-C1-C6-alkoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 3-10 member heterocyclyl-C1-C6-alkoxy Lucoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), aryl(C1-C6)alkoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 5-10 member heteroaryl(C1-C6)alkoxy (may be substituted with halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), sulfhydryl (mercapto ), halo(C1~C6)alkyl (e.g., -CF3), halo(C1~C6)alkoxy (e.g., -OCF3), C1~C6 alkylthio, arylthio (may be substituted with halo, C1~C6 alkyl, C1~C6 alkoxy, C1~C6 haloalkyl and C1~C6 haloalkoxy), C3~C7 carbocykrillthio (may be substituted with halo, C1~C6 alkyl, C1~C6 alkoxy, C1~C6 haloalkyl and C1~C6 haloalkoxy), 3~10 member heterocyclylthio (halo, C1~C6 alkyl, C1~C6 alkoxy) Xyl(C1-C6 haloalkyl and C1-C6 haloalkoxy), 5-10 member heteroaryl-thio(halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), C3-C7-carbocykyl-C1-C6-alkylthio(halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 3-10 member heterocyclyl-C1-C6-alkylthio(halo, C1-C6 alkyl,(may be substituted with C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), aryl(C1-C6)alkylthio(halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy), 5-10 member heteroaryl(C1-C6)alkylthio(halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy) This means that a group is substituted with one or more substituents independently selected from amino, amino(C1-C6)alkyl, nitro, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amide, N-amide, S-sulfonamide, N-sulfonamide, C-carboxy, O-carboxy, acyl, cyanato, isocyanato, thiocyanato, isothiocyanato, sulfinyl, sulfonyl, and oxo (=O). Whenever a group is described as "may be substituted," that group can be substituted with any of the substituents listed above.

[0068] It should be understood that the nomenclature of certain groups can include either monoradicals or diradicals, depending on the context. For example, a substituent is understood to be a diradical if it requires two bonding points to the rest of the molecule. Substituents identified as alkyls that require two bonding points include diradicals such as -CH2-, -CH2CH2-, and -CH2CH(CH3)CH2-. The nomenclature of other groups clearly indicates that the group is a diradical, such as "alkylene" or "alkenylene". Whenever a substituent is indicated as a diradical (i.e., having two bonding points to the rest of the molecule), it should be understood that, unless otherwise indicated, the substituent can be bonded in any directional configuration. Thus, for example, -AE- or [ka] The substituents shown as include substituents oriented so that A is bonded to the leftmost bond site of the molecule, as well as the case where A is bonded to the rightmost bond site of the molecule.

[0069] As used herein, certain substituents or linking groups having only a single atom may be referred to by the name of the atom. For example, in some cases, the substituent "-H" may be referred to as "hydrogen" or "hydrogen atom," the substituent "-F" as "fluorine" or "fluorine atom," and the linking group "-O-" as "oxygen" or "oxygen atom."

[0070] The bonding points of a group are generally indicated by a terminal dash (-) or an asterisk (*). For example, both *-CH2-CH3 and -CH2-CH3 represent an ethyl group.

[0071] Chemical structures are often represented using a "skeleton" form, where carbon atoms are not explicitly shown and hydrogen atoms bonded to carbon atoms are completely omitted. For example, structure [ka] This represents butane (i.e., n-butane). Furthermore, aromatic groups such as benzene are represented by indicating one of the resonance structures to which they contribute. For example, structure [ka] This represents toluene.

[0072] As used herein, “optionally” means that the events described below may or may not occur. In some embodiments, the optional events do not occur. In some other embodiments, the optional events occur one or more times.

[0073] As used herein, “or” should be given its broadest reasonable interpretation and should not be limited to a binary configuration. Thus, the phrase “containing A or B” means either A exists and B does not exist, or B exists and A does not exist, or both A and B exist. Furthermore, if, for example, A defines a class that can have multiple members, e.g., A1 and A2, then one or more members of the class can exist simultaneously.

[0074] Where used herein, “for example,” “for instance,” “such as,” or “including” means to introduce examples that further clarify a more general subject matter. Unless otherwise specified, such examples are provided solely to aid in understanding the embodiments shown in this disclosure and are not intended to limit them in any way. These phrases do not indicate any preference of any kind for the embodiments disclosed.

[0075] In the first aspect, this disclosure is: a) Compounds of formula (I) [ka] or its salt, in the formula, R 1 is a hydrogen atom, -OH or -OR 1A and; R 1A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 1A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 2 is a hydrogen atom, -OH or -OR 2A and; R 2A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 Alkyl or R 2A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 3 is -OH or -OR 3A and; R 3A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 3A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 4 is a hydrogen atom, -OH or -OR 4A and; R 4A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 4A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 5 These are hydrogen atoms, -OH, and -OR 5A or -OC(O)-R 5B and; R 5A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 5AThis is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 5B is -H, or -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; R 6 and R 7 C 1~6 alkyl, -OH, C 1~6 Alkoxy and -O-(C 1~6 Alkylene)-O-(C 1~6 Selected from the group consisting of alkyls; m is 0, 1 or 2; and n is 0, 1, 2, or 3; or Compound of formula (II) [ka] or its salt, in the formula, R 8 is a hydrogen atom, -OH or -OR 8A and; R 8A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 8A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 9 is a hydrogen atom, -OH or -OR 9A and; R 9A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6Alkyl or R 9A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 10 is -OH or -OR 10A and; R 10A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 10A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 11 is a hydrogen atom, -OH or -OR 11A and; R 11A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 11A This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 12 These are hydrogen atoms, -OH, and -OR 12A or -OC(O)-R 12B and; R 12A is -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; or R 12AThis is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose and pyranose moieties, linked by glycosidic bonds; R 12B is -H, or -OH and C 1~6 C may be substituted one or more times with substituents selected from the group consisting of alkoxys. 1~6 It is alkyl; R 13 and R 14 C 1~6 alkyl, -OH, C 1~6 Alkoxy and -O-(C 1~6 Alkylene)-O-(C 1~6 Selected from the group consisting of alkyls; m' is 0, 1 or 2; and n' is 0, 1, 2, or 3; or a combination thereof; b) Oils containing carbonone; and c) Optionally, solvent This relates to a liquid composition containing [a specific substance].

[0076] In some embodiments, the liquid composition contains a compound of formula (I). The compound of formula (I) is a flavanone or flavanone derivative within the flavonoid class of the compound. The compound of formula (I) can act as a taste modifier, such as a cooling enhancer, a sweetener, or a bitterness blocker.

[0077] In one embodiment, R 5 This is a hydrogen atom, -OH or -OC(O)-R 5B And in the formula, R 5B Typically, C 1~6 Alkyl, typically methyl.

[0078] In another embodiment, R 1 is -OH or -OR 1A And R 2 is -OH or -OR 2A And R 3is -OH or -OR 3A And R 4 is -OH or -OR 4A Therefore, m is 0, and n is 0.

[0079] Examples of compounds of formula (I) suitable for use as described herein include, but are not limited to, hesperetin, naringenin, eriodictyol, homoeriodictyol, sterbin, aromadendrin, aromadendrin-3-O-acetate, or any salt or glycoside thereof.

[0080] Other exemplary compounds of formula (I) suitable for use as disclosed herein include, but are not limited to, naringin, hesperidin, (2R,3R)-3-acetoxy-5,7,4'-trihydroxyflavanone, (2R,3R)-3-acetoxy-5,7,3'-trihydroxy-4'-methoxyflavanone, 3-methoxy-5,3'-dihydroxy-4'-methoxyflavanone (racemic), nobiletin, polymethoxyflavones, mixed methoxy- and hydroxyflavones, quercetin, persicogenin, or any salts or glycosides thereof.

[0081] In one embodiment, the liquid composition comprises a compound of formula (II). The compound of formula (II) is a dihydrochalcone or dihydrochalcone derivative within the flavonoid class of the compound. The compound of formula (II) can act as a taste-modifying compound, such as a cooling-enhancing compound, a sweetness-enhancing compound, or a bitterness-blocking compound.

[0082] In one embodiment, R 12 This is a hydrogen atom.

[0083] In another embodiment, R 8 is -OH or -OR 8A And R 9 is -OH or -OR 9A And R 10 is -OH or -OR 10A And R 11 is -OH or -OR11A Therefore, m' is 0, and n' is 0.

[0084] Non-limiting examples of compounds of formula (II) include, but are not limited to, naringin dihydrochalcone, hesperetin dihydrochalcone, hesperetin dihydrochalcone 4'-O-glucoside, neohesperidin dihydrochalcone, and phloretin.

[0085] Surprisingly, it has been discovered that compounds of formula (I) and / or formula (II) can be solubilized at high concentrations using carbone and optionally an oil containing a solvent to provide a clear and homogeneous solution. The term "clear" means that a solution without colorants or fluorescent agents has a transmittance value of 100% in visible light (500-800 nm) at a path length of 1 cm relative to desalinated water. Thus, in one embodiment, the liquid composition is a clear and homogeneous solution.

[0086] In one embodiment, a clear, homogeneous solution is also stable. The term stable means that the liquid composition does not undergo phase separation and remains clear without any detectable signs of turbidity, cloudiness, or precipitation over a long period of time, typically at least a few days, more typically at least a few weeks, and even more typically at least a few months or longer, at room temperature or within a specific temperature range (e.g., room temperature ± 10 to 20°C, typically 10 to 45°C, more typically 3 to 45°C).

[0087] Oils containing carvone can be any source of carvone known to those skilled in the art. Carvone (2-methyl-5-(propa-1-en-2-yl)cyclohexa-2-en-1-one) is a terpenoid compound that can be obtained by chemical synthesis or by extraction from natural sources using known methods. Carvone has two enantiomer forms, R-(-)-carvone (also known as laevo(L)-carvone) and S-(+)-carvone (also known as dextro(D)-carvone). In this disclosure, racemic mixtures of divided carvone and its enantiomers are intended. Racemic mixtures of divided carvone and its enantiomers may be neat, i.e., pure, or unmixed with other materials, or as part of a mixture such as an extract. In one embodiment, the oil containing carvone is neat carvone, spearmint oil, caraway seed oil, or dill oil. Spearmint oil is commercially available as a mint spicata extract containing a certain amount of carvone, for example, Mint Spicata 60% Carvone and Mint Spicata China 80% Carvone, among others. In some embodiments, the oil containing carvone is food grade.

[0088] In some embodiments, the optional solvent may include one or more solvents typically used in the flavor or cosmetic industry, provided that one or more solvents do not adversely affect the clarity and homogeneity of the liquid composition. In one embodiment, the optional solvent includes one or more solvents selected from the group consisting of 1-propanol (n-propyl alcohol), 2-propanol (isopropyl alcohol), ethanol, propylene glycol, triethyl citrate, triacetin, glycerol, 1,3-propanediol, ethyl lactate, and benzyl alcohol.

[0089] If present, the weight ratio of the amount of oil containing carbone to the amount of the optional solvent is not particularly limited. However, in some embodiments, if present, the weight ratio of the oil containing carbone to the amount of the optional solvent is 1:99 to 99:1, typically 10:90 to 90:10, and more typically 30:70 to 90:10. In some embodiments, if present, the weight ratio of the oil containing carbone to the amount of the optional solvent is 30:70, 40:60, 50:50, 60:40, 70:30, 80:20, or 90:10.

[0090] In one embodiment, the liquid composition comprises an oil containing carvone and one or more solvents selected from the group consisting of 1-propanol (n-propyl alcohol), 2-propanol (isopropyl alcohol), ethanol, propylene glycol, triethyl citrate, triacetin, glycerol, 1,3-propanediol, ethyl lactate, and benzyl alcohol. In one embodiment, the liquid composition comprises an oil containing carvone and two solvents selected from the group consisting of 1-propanol (n-propyl alcohol), 2-propanol (isopropyl alcohol), ethanol, propylene glycol, triethyl citrate, triacetin, glycerol, 1,3-propanediol, ethyl lactate, and benzyl alcohol.

[0091] As described herein, the compounds of formula (I) and / or formula (II) can be solubilized at high concentrations. In one embodiment, the components of the compounds of formula (I) and / or formula (II) are present in an amount of at least 6% by weight, typically at least 10% by weight, and more typically at least 15% by weight, based on the total weight of the composition. In some embodiments, the compounds of formula (I) and / or (II) are present in an amount of 6% to 50% by weight, typically 10% to 40% by weight, and more typically 15% to 30% by weight, based on the total weight of the liquid composition.

[0092] In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of at least 7% by weight, at least 7.5% by weight, at least 8% by weight, at least 8.5% by weight, at least 9% by weight, at least 9.5% by weight, at least 10% by weight, at least 10.5% by weight, or at least 11% by weight, based on the total weight of the composition.

[0093] In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 7% to 50% by weight, typically 7% to 40%, more typically 7% to 30%, and even more typically 7% to 25% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 7.5% to 50% by weight, typically 7.5% to 40%, more typically 7.5% to 30%, and even more typically 7.5% to 25% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 8% to 50% by weight, typically 8% to 40%, more typically 8% to 30%, and even more typically 8% to 25% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 8.5% to 50% by weight, typically 8.5% to 40%, more typically 8.5% to 30%, and even more typically 8.5% to 25% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 9% to 50% by weight, typically 9% to 40%, more typically 9% to 30%, and even more typically 9% to 25% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 9.5% to 50% by weight, typically 9.5% to 40%, more typically 9.5% to 30%, and even more typically 9.5% to 25% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 10% to 50% by weight, typically 10% to 40%, more typically 10% to 30%, and even more typically 10% to 25% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 10.5% to 50% by weight, typically 10.5% to 40%, more typically 10.5% to 30%, and even more typically 10.5% to 25% by weight, relative to the total weight of the liquid composition.In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 11% to 50% by weight, typically 11% to 40%, more typically 11% to 30% by weight, and even more typically 11% to 25% by weight, relative to the total weight of the liquid composition.

[0094] In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 7% to 25% by weight, 7% to 24% by weight, 7% to 23% by weight, 7% to 22% by weight, 7% to 21% by weight, or 7% to 20% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 7.5% to 25% by weight, 7.5% to 24% by weight, 7.5% to 23% by weight, 7.5% to 22% by weight, 7.5% to 21% by weight, or 7.5% to 20% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 8% to 25% by weight, 8% to 24% by weight, 8% to 23% by weight, 8% to 22% by weight, 8% to 21% by weight, or 8% to 20% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 8.5% to 25% by weight, 8.5% to 24% by weight, 8.5% to 23% by weight, 8.5% to 22% by weight, 8.5% to 21% by weight, or 8.5% to 20% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 9% to 25% by weight, 9% to 24% by weight, 9% to 23% by weight, 9% to 22% by weight, 9% to 21% by weight, or 9% to 20% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 9.5% to 25% by weight, 9.5% to 24% by weight, 9.5% to 23% by weight, 9.5% to 22% by weight, 9.5% to 21% by weight, or 9.5% to 20% by weight, relative to the total weight of the liquid composition. In some embodiments, compounds of formula (I) and / or (II) are present in amounts of 10% to 25% by weight, 10% to 24% by weight, 10% to 23% by weight, 10% to 22% by weight, 10% to 21% by weight, or 10% to 20% by weight, relative to the total weight of the liquid composition.In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 10.5% to 25% by weight, 10.5% to 24% by weight, 10.5% to 23% by weight, 10.5% to 22% by weight, 10.5% to 21% by weight, or 10.5% to 20% by weight, relative to the total weight of the liquid composition. In some embodiments, the compounds of formula (I) and / or (II) are present in amounts of 11% to 25% by weight, 11% to 24% by weight, 11% to 23% by weight, 11% to 22% by weight, 11% to 21% by weight, or 11% to 20% by weight, relative to the total weight of the liquid composition.

[0095] In some embodiments, the compounds of formula (I) and / or (II) are present in an amount of 7% to 11% by weight, typically 7% to 10% by weight, and more typically 7% to 9% by weight, relative to the total weight of the liquid composition.

[0096] In a second aspect, the disclosure relates to a consumer product comprising a liquid composition described herein.

[0097] Consumer products may contain cooling compounds. "Cooling compounds" refers to compounds that modulate TRPM8 receptors.

[0098] Examples of cooling compounds include (-)-menthol, N-ethyl-p-menthyl-3-carboxamide, cubebol, isopulegol, 3-(L-menthoxy)propane-1,2-diol, cis / trans-p-menthane-3,8-diol, 3-(L-menthoxy)-2-methylpropane-1,2-diol, 2-[2-(p-menthane-3-yloxy)ethoxy]ethanol, menthoxyethanol, (1R,2R,4R)-1-(2-hydroxy-4-methylcyclohexyl)ethenone, (1R,2R,5R)-N-ethyl-5-methyl-2- (Propa-1-en-2-yl)-cyclohexanecarboxamide, N-(3-hydroxy-4-methoxyphenyl)-2-isopropyl-5,5-dimethylcyclohexanecarboxamide, N-[4-(cyanomethyl)phenyl]-2-isopropyl-5,5-dimethylcyclohexanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, L-menthol lactate, (-)-menthylethylene glycol carbonate, (-)-menthone 1,2-glycerol Glycerol ketal, D / L-menthone 1,2-glycerol ketal, (-)-menthyl 1-propylene glycol carbonate, (-)-menthyl 2-propylene glycol carbonate, D / L-menthyl 1-propylene glycol carbonate, D / L-menthyl 2-propylene glycol carbonate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide, menthyl ethylamide oxalate, (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl- 2-Propenamide, 3,4-Methylenedioxycinnamic acid, N,N-Diphenylamide, N,N-Dimethyl(-)-Menthylsuccinimide, (1R,2S,5R)-N-(4-(Carbamoylmethyl)phenyl)-Menthylcarboxamide, (-)-Menthylpyrrolidone carboxylate, L-Phenylephrine p-Menthanecarboxamide, (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)Menthylcarboxamide, (1R,2S,5R)-N-(2-(Pyridine-2-yl)ethyl)Menthylcarboxamide, 6-Isopropyl-3,9-Dimethyl-1,4-dioxaspiro[4.5]decan-2-one, (1R,2R,4S)-dihydroumbellol, N-ethyl-p-menthane-3-carboxamide, 2-isopropyl-N,2,3-trimethylbutylamide, ethyl-3-(p-menthane-3-carboxamide)acetate, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-dimethylbutanamide, N-cyclopropyl-5-methyl-2-isopropyl-cyclohexanecarbone Examples of compounds selected from the group consisting of carboxamide, (-)-acetoacetate menthyl, (-)-succinate menthyl, (-)-menthyl(S)-3-hydroxybutyrate, (-)-menthyl glutarate, 1-[2-hydroxyphenyl]-4-[2-nitrophenyl]-1,2,3,6-tetrahydropyrimidine-2-one, di-(-)-menthyl glutarate, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, and any combination thereof, are not limited to these.

[0099] In some embodiments, the cooling compound is a cooling compound described in International Publication No. 2021 / 074281, for example, (2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)(1,2,3-thiadiazole-5-yl)methanone, (2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)(thiethane-3-yl)methanone, (2,2-dimethylcyclopropyl)(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)methanone, ( 2-Ethoxycyclopropyl)(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)methanone, (2-methoxycyclopropyl)(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)methanone, (2-methylcyclopropyl)(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)methanone, (2S)-2-methyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, (5-methyl (E)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)methanone, (E)-1-(2-(5-(3,4-difluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbuta-2-en-1-one, (E)-2-methyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)buta-2-en-1-one, (E)-2-methyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl )piperidine-1-yl)penta-3-en-1-one, (R)-2-(methylthio)-1-((R)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, (S)-2-(methylthio)-1-((R)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, (S)-2-(methylthio)-1-((S)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one,(S)-2-methyl-1-((R)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, (tetrahydrofuran-3-yl)(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)methanone, 1-(2-(1H-benzo[d]imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(1-methyl-1H-pyrazole-4-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio O)propan-1-one, 1-(2-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2,3-dihydrobenzofuran-5-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2,3-dihydrobenzofuran-6-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1- On, 1-(2-(4-(2,5-dimethylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2-chlorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2-cyclopropyloxazole-5-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2-fluorophenyl)-1H-imidazole-2- (yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(2-hydroxyphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(3-((dimethylaminomethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(3,5-difluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one,1-(2-(4-(3,5-dimethylisoxazole-4-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(3-chloro-4-methylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(3-methylfuran-2-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-((1,1-dioxide Thiomorpholino)methyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-(1-hydroxyethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-(difluoromethoxy)-3-fluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-(difluoromethyl) (Ophen-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, (2-(4-(4-(methylsulfonyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, (2-(4-(4-(tert-butyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, (2-(4-(4-cyclobutylphenyl)-1H-imidazole-2-yl) Peridine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-cyclopropyl-2-fluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-fluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-hydroxyphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one,1-(2-(4-(4-isopropylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(4-methyl-3-(trifluoromethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(5-((dimethylaminomethyl)thiophen-2-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-(5-methylfur (I-2-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, (2-(4-(5-methylpyridine-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, (2-(4-(6-methylpyridine-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, (2-(4-(benzo[b]thiophene-6-yl)-1H-imidazole-2-yl)piperidine-1-yl) -2-(methylthio)propan-1-one, 1-(2-(4-methyl-5-phenyl-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)-2-((trifluoromethyl)thio)ethane-1-one, 1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)hexa-3,5-die n-1-one, 1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)penta-4-en-1-one, 1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 1-(2-(5-(2,3-difluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(2,4-difluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one,1-(2-(5-(2,5-difluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(2-fluoro-4-methoxyphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(2-fluoro-4-methylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1- On, 1-(2-(5-(2-methoxypyrimidine-5-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-(methylamino)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3,4-difluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one n, 1-(2-(5-(3,4-difluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbuta-3-en-1-one, 1-(2-(5-(3,4-dimethoxyphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3,4-dimethylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2 -(5-(3-fluoro-4-(methoxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-fluoro-4-methylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-fluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-methoxyisothiazole-4-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(3-methoxyphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-((methylaminomethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-(2-methoxyethyl)phenyl)-1H -Imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-(aminomethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-(dimethylamino)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio O)propan-1-one, 1-(2-(5-(4-acetylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-aminophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-chloro-3-fluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-chlorophenyl)-1H-imidazole- 2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-ethylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-fluorophenyl)-4H-1,2,4-triazole-3-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-methoxy-2-methylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one,1-(2-(5-(4-methoxyphenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(4-methyl-6-(methylthio)pyridine-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(5-(methoxymethyl)thiophen-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(6-methoxypyridine-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(benzo [d] [1,3]Dioxol-5-yl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 1-(2-(5-benzyl-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-(5-benzyl-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio) Ropan-1-one, 1-(2-(5-bromo-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 2-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)benzonitrile, 2-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-carb Nyl)cyclopropane-1-carbonitride, 2-(5-methylfuran-2-yl)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(allylthio)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(dimethylamino)-1-(2 -(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-(dimethylamino)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(ethylthio)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one,2-(furan-2-yl)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)ethane-1-one, 2-(furan-2-yl)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propane-1-one, 2-(furan-3-yl)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)ethane-1-one, 2-(furan-3-yl)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl) Propan-1-one, 2-(methylamino)-N-(4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)phenyl)acetamide, 2-(methylsulfinyl)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylsulfonyl)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)ethane-1-one, 2-(methylsulfonyl)-1-(2-(4-phenyl (1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, (2-(methylthio)-1-(2-(2-(p-tolyl)-2H-tetrazol-5-yl)piperidine-1-yl)propan-1-one, (methylthio)-1-(2-(3-phenyl-1,2,4-oxadiazole-5-yl)piperidine-1-yl)propan-1-one, (methylthio)-1-(2-(4-(1-(trifluoromethyl)-1H-pyrazole-4-yl)-1H-imidazole-2-yl)piperidine-1-yl) Propan-1-one, 2-(methylthio)-1-(2-(4-(4-(morpholinomethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(5-(trifluoromethyl)furan-2-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(5-(trifluoromethyl)thiophen-2-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one,2-(methylthio)-1-(2-(4-(5-methylthiophen-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(m-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(o-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(pyridine-3-yl)-1H-imidazole-2-yl (Lu)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(pyridin-4-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(pyrimidine-5-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(quinoxaline-6-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2- (4-(thiophen-3-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)ethane-1-one, 2-(methylthio)-1-(2-(5-(2-(trifluoromethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(2,3,4-trifluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)piper Zin-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(2,4,5-trifluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(3-(trifluoromethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(4-(trifluoromethoxy)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one,2-(methylthio)-1-(2-(5-(4-(trifluoromethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(4-propylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(4-vinylphenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(5-methylthiophen- 2-yl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)-1,3,4-oxadiazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)azepan-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methyl Thio)-1-(2-(5-(p-tolyl)-4H-1,2,4-triazole-3-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)isoxazole-3-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)oxazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)thiazol-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-phenyl-1H-imidazole-2-yl)pyrrolidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-phenyl-4H-1,2,4-triazole-3-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(5-phenyloxazole-2-yl)piperidine-1-yl)propan-1-one, 2-(methylthio)-1-(4-(5-(p-tolyl)-1H-imidazole-2-yl)thiazolidin-3-yl)propan-1-one, 2,2,3-trimethyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)buta-3-en-1-one, 2,2,3-trimethyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2,2-dimethyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)buta- 3-en-1-one, 2,2-dimethyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2,3-dimethoxy-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2,3-dimethyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2,5-difluoro-4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-4-yl )benzonitrile, 2-amino-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-cyclobutyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-cyclopentyl-2-ethoxy-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)ethane-1-one, 2-cyclopropyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)ethane-1-one , 2-cyclopropyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-cyclopropyl-2-methoxy-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)ethane-1-one, 2-ethoxy-1-(2-(5-(3-fluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-ethyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)buta-2-en-1-one,2-Ethyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-Fluoro-4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)benzonitrile, 2-Mercapto-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-Methoxy-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2 -Methoxy-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-Methoxy-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-Methyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-Methyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-Methyl-1-(2-(5- (p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)buta-3-en-1-one, 2-methyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-methyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1,3-dione, 2-methyl-1-(2-(5-((p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)pentan-1-one, 2-methyl-1-(2-(5-( p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-2-en-1-one, 2-methyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-methyl-2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-methyl-3-(methylthio)-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one,2-Methylene-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 3-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-4-yl)benzonitrile, 3,3,3-trifluoro-2-methyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 3,3,4,4,4-pentafluoro-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine- 1-yl)butan-1-one, 3,3-difluoro-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 3-fluoro-4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)benzonitrile, 3-methyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)buta-2-en-1-one, 3-methyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1- 1.1.1] benzonitrile, 4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-4-yl)benzonitrile, 4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)benzaldehyde, 4,4,4-trifluoro-2-methyl-1-(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, bicyclo[1.1.1]pentan-1-yl(2-(4-phenyl-1H-imidazole (2-yl)piperidine-1-yl)methanone, cyclobutyl(2-(5-(3-fluorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)methanone, cyclopentyl(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)methanone, cyclopropyl(2-(4-phenyl-1H-imidazole-2-yl)piperidine-1-yl)methanone, methyl4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)benzoate,N-(2-hydroxyethyl)-4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-4-yl)benzenesulfonamide, 2-(methylthio)-1-(2-(5-(3-nitrophenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, N-(4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-4-yl)phenyl)methanesulfonamide, 2-(methylthio)-1-(2-(5-(4-nitro (lophenyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 1-(sec-butylsulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(sec-butylsulfonyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(isopropylsulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(isopropylsulfonyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl )piperidine, 1-((1-(methylthio)ethyl)sulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-((1-(methylthio)ethyl)sulfonyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-((2-(methylthio)propan-2-yl)sulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-((2-(methylthio)propan-2-yl)sulfonyl)-2-(5-(p-tolyl)-1H-imidazole (Lu-2-yl)piperidine, 1-(buta-3-en-2-ylsulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(buta-3-en-2-ylsulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(penta-3-en-2-ylsulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(penta-3-en-2-ylsulfonyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine,1-((2-methylbuta-3-en-2-yl)sulfinyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-((2-methylbuta-3-en-2-yl)sulfonyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 2-(methylsulfonyl)-1-(2-(5-(p-tolyl)-1H-imidazole (2-yl)piperidine-1-yl)propan-1-one, 1-(4-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(5-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(4-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(5-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylsulfonyl)propan-1-one, 1-(4-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylsulfonyl)propan-1-one, 1-(5-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2- (Iyl)piperidine-1-yl)-2-(methylsulfonyl)propan-1-one, 1-(2-hydroxy-6-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-hydroxy-6-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(2-hydroxy-6-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylsulfonyl)propan-1-one, 1-(3- Hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(3-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(3-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylsulfonyl)propan-1-one, 1-(2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine -1-yl)-2-(methylsulfinyl)propan-1-one, 1-(4-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)2-(methylsulfinyl)propan-1-one, 1-(5-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylsulfinyl)propan-1-one, 1-(2-hydroxy-6-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylsulfinyl)propan-1-one,1-(3-hydroxy-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylsulfinyl)propan-1-one, 1-(2-hydroxy-6-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(5-hydroxy-2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(4-hydroxy C-2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(3-hydroxy-2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-(methylthio)propan-1-one, 1-(2-hydroxy-6-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(5-hydroxy-2-(5-( 4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(4-hydroxy-2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(3-hydroxy-2-(5-(4-(hydroxymethyl)phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 4-(2-(1-(2-methylbutanoyl)piperidine-2-yl)-1H -Imidazole-5-yl)benzaldehyde, 4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)benzoic acid, 4-(2-(1-(2-methylbutanoyl)piperidine-2-yl)-1H-imidazole-5-yl)benzoic acid, (2,2-dimethylcyclopropyl)(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)methanone, 1-(2-(5-bromo-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one,1-(2-(5-(4-chlorophenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 2-(4-(2-(1-(2-(methylthio)propanoyl)piperidine-2-yl)-1H-imidazole-5-yl)phenyl)acetonitrile, 2-(4-(2-(1-(2-methylbutanoyl)piperidine-2-yl)-1H-imidazole-5-yl)phenyl)acetonitrile, 2-(4-(2-(1-(2-methylbutanoyl)piperidine-2-yl )-1H-imidazole-5-yl)phenyl)acetonitrile, 2,3-dimethyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-methyl-1-(2-(5-(o-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-methyl-1-(2-(5-(m-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 1-(2-(5-(4-(hydroxymethyl) Phenyl)-1H-imidazole-2-yl)piperidine-1-yl)-2-methylbutan-1-one, 1-(isopropylsulfonyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 1-(sec-butylsulfonyl)-2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine, 2-methyl-1-(2-(5-(5-methylthiophen-2-yl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-(methylthio)- These may include 1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperazine-1-yl)propan-1-one, 2-(methylthio)-1-(2-(4-(p-tolyl)oxazole-2-yl)piperidine-1-yl)propan-1-one, 2-methyl-1-(2-(4-(p-tolyl)oxazole-2-yl)piperidine-1-yl)butan-1-one, their derivatives such as those described in International Publication No. 2022 / 170519, and any combination thereof.

[0100] In some embodiments, the cooling compound may be 2-methyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)butan-1-one, 2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2-methyl-2-(methylthio)-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)propan-1-one, 2,2-dimethyl-1-(2-(5-(p-tolyl)-1H-imidazole-2-yl)piperidine-1-yl)buta-3-en-1-one, or a combination thereof.

[0101] In some embodiments, the cooling compound may be 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole, 5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole (including (3aR,5R,7S,7aR)-5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole, (3aR,5R,7R,7aR)-5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole, (3aR,5R,7S,7aS)-5-(4-fluorophenyl)-1,3,3,5,7-pentamethyloctahydrobenzo[c]isoxazole), or any combination thereof.

[0102] Consumer products may contain cooling-enhancing compounds. As used herein, “cooling-enhancing compounds” can enhance the cooling sensation provided by consumer products containing cooling compounds, but can also provide a cooling sensation on their own. Such cooling-enhancing compounds include, but are not limited to, naturally occurring compounds such as menthol or its analogues, or synthetic compounds such as any compounds described in U.S. Patent No. 9,394,287 and U.S. Patent No. 10,421,727. Examples of cooling-enhancing compounds include N-ethyl-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide; N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide; 2-(4-fluorophenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-(2-hydroxy-4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-((2,3-dihydro-1H-inden-5-yl)oxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-((2,3-dihydro Examples of compounds selected from the group consisting of di-1H-inden-5-yl)oxy)-N-(1H-pyrazole-3-yl)-N-(thiazole-5-ylmethyl)-acetamide; 5-methoxy-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)benzofuran-2-carboxamide; 2-(4-ethylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide; (E / Z)-2-methyl-2-butenal; (E / Z)-2-isopropyl-5-methyl-2-hexenal; derivatives thereof, such as those described in International Publication No. 2022 / 170519, and any combination thereof.

[0103] Consumer products can be flavored products, typically food, beverage products, oral care products, or pharmaceuticals.

[0104] Flavored products may contain sweeteners. As used herein, “sweetener” means a compound that induces a detectable sweet flavor in a subject, or an ingestively acceptable salt thereof, e.g., a compound that activates T1R2 / T1R3 receptors in vitro. Sweeteners may include low-calorie, zero-calorie, or high-intensity sweeteners. The term “high-intensity sweetener” means a sweetener that is sweeter than sucrose, e.g., a sweetener that is at least 10 times, or at least 20 times, or at least 50 times, or at least 100 times, or at least 250 times, or at least 500 times, or at least 750 times, or at least 10000 times, or at least 2500 times, or at least 5000 times, or at least 7500 times, or at least 10000 times sweeter than sucrose. In this regard, when a sweetener is said to be x times sweeter than sucrose, it means that a concentration of the sweetener in an aqueous solution that is 1 / x times the weight of sucrose produces the same level of sweetness as sucrose.

[0105] Examples of suitable sweeteners are described in more detail below. In some embodiments, the sweetener is sucralose, which refers to 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside. In some embodiments, the sweetener is sodium saccharin. Sodium saccharin can be present at any suitable concentration. In some embodiments, the concentration of sodium saccharin is in the range of 10 ppm to 10,000 ppm, or 50 ppm to 5,000 ppm, or 100 ppm to 3,000 ppm.

[0106] In some embodiments, the sweetener may include glucosylated natural steviol glycosides. As used herein, the term “natural steviol glycoside” refers to steviol glycosides found naturally in plants of the species Stevia rebaudiana, Stevia phlebophylla, or Rubus chingii. Such compounds are glycosides of steviol, which is a diterpene. Some non-limiting examples include stevioside, rebaudioside A, rebaudioside C, and dulcoside A. As used herein, the term “glucosylated natural steviol glycoside” refers to compounds obtained by enzymatic glucosylation of natural steviol glycosides to increase the degree of glucosylation. As used herein, the term “GSG” is used interchangeably with “glucosylated natural steviol glycoside.”

[0107] In embodiments where a GSG is present, any suitable GSG can be used. Thus, the GSG can have any suitable further degree of glucosylation and any suitable type of glucosylation. In some embodiments, the GSG used has a degree of glucosylation of at least 1.0, meaning that at least 1 mole of glucose per mole of natural steviol glycoside is enzymatically added to the natural steviol glycoside. In some other embodiments, the GSG used has a degree of glucosylation of at least 1.1, or at least 1.2, or at least 1.3, or at least 1.4, or at least 1.5, or at least 1.6, or at least 1.7, or at least 1.8, or at least 1.9, or at least 2.0, or at least 2.1, or at least 2.2, or at least 2.3, or at least 2.4, or at least 2.5. The glucosylation can be of any suitable type. For example, in some embodiments, the glucose enzymatically added to the natural steviol glycoside is α-glucose, β-glucose, or a combination thereof. In some embodiments, the glucose enzymatically added to the natural steviol glycoside is α-glucose. In some embodiments, the glucose enzymatically added to the natural steviol glycoside is β-glucose. In some embodiments, the glucose enzymatically added to the natural steviol glycoside is a combination of α-glucose and β-glucose. The glucose added by enzymatic glucosylation can be incorporated via any suitable linkage. Typically, the added glucose unit is linked to another glucose unit already present on the natural steviol glycoside. In some embodiments, the enzymatically added glucose unit is added via a 1,6 linkage, meaning the glucose unit is added via position 1 of the added glucose unit and position 6 of a glucose unit already present on the natural steviol glycoside. In some other embodiments, the enzymatically added glucose unit is added via a 1,4 linkage. In some other embodiments, the enzymatically added glucose unit is added via a 1,2 linkage.

[0108] In embodiments where GSG is present, GSG can be present at any appropriate concentration. In some embodiments, GSG is present at concentrations ranging from 1 ppm to 100 ppm, or 1 ppm to 50 ppm, or 1 ppm to 30 ppm, or 1 ppm to 20 ppm, or 1 ppm to 10 ppm.

[0109] In some embodiments, the sweetener may include calorie sugars such as sucrose, glucose, fructose (e.g., in the form of high-fructose corn syrup), or any combination thereof. In some embodiments, the sweetener may include one or more rebaudiosides (such as rebaudioside A, rebaudioside D, rebaudioside E, rebaudioside M, or any combination thereof). Generally, the concentration of rebaudiosides (such as rebaudioside A) is about 20 to 50 times higher than the concentration of sucralose described above. In some embodiments, the sweetener may include one or more high-intensity artificial sweeteners such as acesulfame potassium, aspartame, cyclamate, and neotame. If any of these high-intensity artificial sweeteners are present, their concentrations are approximately the same as those of sucralose described above. In some other embodiments, the sweetener may include one or more low-calorie carbohydrates or sugar alcohols such as allulose, xylitol, and erythritol. In some other embodiments, the sweetener may be, for example, monk fruit juice or extract, or mogroside III, mogroside IV, mogroside V, siamenoside I, isomogroside V, mogroside IV E Isomogloside IV E , isomogroside IV, mogroside III E The present invention includes mogrosides as one or more of 11-oxomogroside V, the 1,6-α isomer of siamenoside I, and any combination thereof. Further mogroside compounds that may be suitably used as sweeteners are described in U.S. Patent Application Publication No. 2017 / 0119032.

[0110] The consumer products described herein, typically flavored products, may also contain a variety of other sweeteners. Non-limiting examples include D-psicose, L-ribose, D-tagatose, L-glucose, L-fucose, L-arabinose, D-turanose, D-leucose, isomalt, lactitol, mannitol, sorbitol, maltodextrin, saccharin, alitame, cyclamic acid, tagatose, maltose, galactose, mannose, lactose, D-tryptophan, glycine, maltitol, lactitol, isomalt, hydrolyzed hydrogenated starch (HSH), chemically modified mogrosides (such as glucosylated mogrosides), carrelame and other guanidine-based sweeteners, honey, Jerusalem artichoke syrup, licorice root, monk fruit (fruit, powder or extract), lucuma (fruit, powder or extract), maple sap (e.g., Acer saccharum, Acer nigram). Examples of sap include that extracted from Acer nigrum, Acer rubrum, Acer saccharinum, Acer platanoides, Acer negundo, Acer macrophyllum, Acer grandidentatum, Acer glabrum, and Acer mono), maple syrup, maple sugar, walnut sap (for example, sap extracted from Juglans cinerea, Juglans nigra, Juglans ailatifolia, and Juglans regia), and birch sap (for example, Betula papillophila). Betula papyrifera), Betula alleghaniensis, Betula lenta, Betula nigra, Betula populifolia,Examples include sap extracted from Betula pendula, fig sap (e.g., sap extracted from Platanus occidentalis), ironwood sap (e.g., sap extracted from Ostrya virginiana), muscovado, molasses (e.g., molasses), molasses sugar, monatin, monellin, cane sugar (also called natural sugar, unrefined cane sugar, or sucrose), palm sugar, panocha, pironchilo, lapadula, raw sugar, rice syrup, sorghum, sorghum syrup, cassava syrup (also called tapioca syrup), thaumatin, yacon root, malt syrup, barley malt syrup, barley malt flour, beet sugar, cane sugar, crystalline fruit juice crystals, caramel, Carbitol, carob syrup, caster sugar, hydrogenated starch aqueous extract, hydrolyzed canned juice, hydrolyzed starch, invert sugar, anethole, arabinogalactan, alope syrup, P-4000, acesulfame potassium (also called acesulfame K or ace K), alitame (also called acreme), advantame, aspartame, bayunoside, neotame, benzamide derivatives, bernadame, canderel, carrera Carrelame and other guanidine-based sweeteners, vegetable fiber, corn sugar, coupling sugars, curculin, cyclamate, cyclocarioside I, demerara, dextran, dextrin, saccharified malt, dulcin, sucrose, valzin, dulcoside A, dulcoside B, emulin, enoxolone, maltodextrin, saccharin, estragole, ethylmaltol, glycine, gluconic acid, gluconolactone, glucosamine, glucoronic acid Glycerol, glycine, glycifylline, glycyrrhizin, glycyrrhetinic acid monoglucuronide, golden sugar, yellow sugar, golden syrup, granulated sugar, gynostema, hernandarsin, isomerized liquid sugar, jalab, chicory root dietary fiber, kynurenine derivatives (including N'-formyl-kynurenine, N'-acetyl-kynurenine, and 6-chloro-kynurenine), galactitol, litesse, ligicane, lycacin,Ragduname, Guanidine, Phalernum, Mavinrin I, Mavinrin II, Maltol, Multisorb, Maltodextrin, Maltotriol, Mannosamine, Miraculin, Starch Syrup, Mogroside (e.g., Mogroside IV, Mogroside V and Neomogroside), Muclodiosides, Nanosugars, Naringin Dihydrochalcone, Neohesperidin Dihydrochalcone, Nib Sugar, Nigero-Oligosaccharides, Norbu, Orgate Syrup, Osradin, Pekmez, Pentadin, Periandrin I, Perillaldehyde, Perillartin, Petophyllum, Phenylalanine, Florisoside I, Florozidine, Phylodulcin, Polyglycitol Syrup, Polypodoside A, Pterocarioside A, Pterocarioside B, Reviana, Purified Syrup, Rub Syrup (rub Examples include syrup, rubusoside, selligueain A, sugar, siamenoside I, Shiraitia grosvenori, soybean oligosaccharide, Splenda, SRI oxime V, steviol glycoside, steviol bioside, stevioside, stroging 1, 2, and 4, sucronate, scrononate, sugar, suosan, phlorizin, super aspartame, tetrasaccharide, slaytol, treacle, trilobtain, tryptophan and its derivatives (6-trifluoromethyl-tryptophan, 6-chloro-D-tryptophan), vanilla sugar, boremitol, chanoxyl syrup, aspartame-acesulfame, asgurin, and any combination or blend of any two or more of these.

[0111] In certain embodiments, consumer products, typically flavored products, include sweeteners selected from the group consisting of sucrose, fructose, glucose, erythritol, sucralose, xylitol, and any combination thereof.

[0112] In some embodiments, consumer products, typically flavored products, may contain 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one or any suitable salt thereof. In some embodiments, consumer products disclosed herein contain a hydrochloride salt of 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one.

[0113] In some embodiments of any of the embodiments described above, consumer products, typically flavored products, may contain lactones. Any suitable lactone or combination of lactones can be used. In some embodiments, the lactones include lactone rings having 3 to 8 members in the ring, such as 3-membered lactone rings, 4-membered lactone rings, 5-membered lactone rings, 6-membered lactone rings, 7-membered lactone rings, or 8-membered lactone rings.

[0114] In some embodiments, the lactone comprises a five-membered lactone ring having or not having an unsaturated bond (excluding unsaturation of an oxo substituent on the ring), such as a carbon-carbon double bond. In some embodiments, the lactone comprises a five-membered lactone ring containing at least one unsaturated bond (e.g., one carbon-carbon double bond). Non-limiting examples of lactones containing a five-membered lactone ring having at least one unsaturated bond include angelicalactone α, angelicalactone β, mintlactone, 5,5-dimethyl-2(5H)-furanone, 5-ethyl-2(5H)-furanone, 5-pentyl-2(5H)-furanone, 5-hexyl-2(5H)-furanone, 5-pentyl-2(3H)-furanone, 4-methyl-3-pentyl-2(5H)-furanone, and 2(5H)-furanone. In some embodiments, the lactone comprises a five-membered lactone ring without an unsaturated bond. Non-limiting examples of such lactones include butyrolactone γ, valerolactone γ, hexalactone γ, heptalactone γ, octalactone γ, undecalactone γ, decalactone γ, dihydrojasmonlactone, and dihydromintlactone (3,6-dimethyl-hexahydro-2(3H)-benzofuranone). In some embodiments, the lactone is dihydromintlactone.

[0115] In some embodiments, the lactone comprises a six-membered lactone ring with or without an unsaturated bond. In some embodiments, the lactone comprises a six-membered lactone ring containing at least one unsaturated bond. Non-limiting examples of lactones containing a six-membered lactone ring with at least one unsaturated bond include δ-2-decenolactone, coumarin, and 6-methylcoumarin. In some other embodiments, the lactone comprises a six-membered lactone ring without an unsaturated bond. Non-limiting examples of lactones containing a six-membered lactone ring without an unsaturated bond include decalactone δ, dodecalactone δ, and cyclohexyllactone.

[0116] In certain embodiments, the consumer product may include, but is not limited to, any additional ingredients or combinations of ingredients commonly used in products such as flavored products: Acids, such as citric acid, phosphoric acid, ascorbic acid, sodium sulfate, lactic acid, or tartaric acid; Bitter components, such as caffeine, quinine, green tea, catechins, polyphenols, green robusta coffee extract, green coffee extract, potassium chloride, menthol, or proteins (proteins and protein isolates derived from plants, algae, or fungi); Coloring agents, such as caramel, red #40, yellow #5, yellow #6, blue #1, red #3, purple carrot juice, black carrot juice, purple sweet potato juice, vegetable juice, fruit juice, beta-carotene, turmeric, curcumin, or titanium dioxide; Preservatives, such as sodium benzoate, potassium benzoate, potassium sorbate, sodium metabisulfate, sorbic acid, or benzoic acid; Antioxidants, such as ascorbic acid, disodium calcium EDTA, alpha-tocopherol, mixed tocopherols, rosemary extract, grape seed extract, resveratrol, or sodium hexametaphosphate; Vitamins or functional ingredients, such as resveratrol, CoQ10, omega-3 fatty acids, theanine, choline chloride (citocorin), fibersol, inulin (chicory root), taurine, ginseng extract, guanana extract, ginger extract, L-phenylalanine, L-carnitine, L-tartrate, D-gluconolactone, inositol, bioflavonoids, echinacea, ginkgo, yerba mate, flaxseed oil, Garcinia cambogia rind extract, white tea extract, ribose, milk thistle extract, grape seed extract, pyrodyxin HCl (vitamin B6), cyanoobalamine n) (Vitamin B12), niacinamide (Vitamin B3), biotin, calcium lactate, calcium pantothenate (pantothenic acid), calcium phosphate, calcium carbonate, chromium chloride, chromium polynicotinate, cupric sulfate, folic acid, ferric pyrophosphate, iron, magnesium lactate, magnesium carbonate, magnesium sulfate, monopotassium phosphate, monosodium phosphate, phosphorus, potassium iodide, potassium phosphate, riboflavin, sodium sulfate, sodium gluconate, sodium polyphosphate, sodium bicarbonate, thiamine mononitrate, vitamin D3, vitamin A palmitate, zinc gluconate, zinc lactate, or zinc sulfate, etc. Whitening agents, such as ester gun, brominated vegetable oil (BVO), or sucrose acetate isobutyrate (SAIB); Buffering agents, such as sodium citrate, potassium citrate, or salts; Flavor, for example, natural flavor, natural flavor including other natural flavors (natural flavor WONF), natural flavor and artificial flavor, artificial flavor, etc.; or Starch and stabilizers, such as pectin, xanthan gum, carboxymethylcellulose (CMC), polysorbate 60, polysorbate 80, medium-chain triglycerides, cellulose gel, cellulose gum, sodium caseinate, modified food starch, gum arabic (acacia gum), inulin, or carrageenan.

[0117] In some further embodiments, the consumer products disclosed herein, typically flavored products, include one or more other umami or flavor-enhancing compounds. Such umami-enhancing compounds include, but are not limited to, naturally derived compounds such as ericamide, or synthetic compounds such as any compounds described in U.S. Patent No. 8,735,081, U.S. Patent No. 8,124,121, and U.S. Patent No. 8,968,708.

[0118] In some further embodiments, the consumer products disclosed herein, typically flavored products, may contain one or more bitterness-blocking compounds. Such bitterness-blocking compounds include, but are not limited to, naturally occurring compounds such as menthol or its analogues, or synthetic compounds such as any compounds described in U.S. Patent No. 8,076,491, U.S. Patent No. 8,445,692, and U.S. Patent No. 9,247,759.

[0119] In some further embodiments, the consumer products disclosed herein, typically flavored products, may contain one or more texture-modifying compounds. Such texture-modifying compounds include, but are not limited to, tannins, cellulosic materials, and bamboo powder.

[0120] In some further embodiments, the consumer products disclosed herein, typically flavored products, may contain one or more flavor-masking compounds. Such flavor-masking compounds include, but are not limited to, cellulosic materials, materials extracted from fungi, materials extracted from plants, citric acid, and carbonates (or carbonates).

[0121] In certain embodiments, the consumer products disclosed herein, typically flavored products, may contain cyclosal. If present, cyclosal is present in relative concentrations similar to those of the lactones described herein.

[0122] In some embodiments, consumer products, typically flavored products, include one or more flavorings or any other additives described in H. Mitchell, Sweeteners and Sugar Alternatives in Food Technology, Blackwell Publishing Ltd, 2006. As used herein, the term “flavoring” includes flavors known to those skilled in the art, such as natural and artificial flavors. These flavorings may be selected from synthetic flavoring oils and flavoring fragrances or oils, oleoresins, and extracts derived from plants, leaves, flowers, fruits, etc., and combinations thereof. Non-limiting representative flavoring oils include spearmint oil, cinnamon oil, wintergreen (methyl salicylate) oil, peppermint oil, Japanese mint oil, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, nutmeg oil, allspice, sage oil, mace, bitter almond oil, and cassia oil. In addition, useful flavorings include vanilla and citrus oils, including lemon, orange, lime, grapefruit, yazu, and sudachi, as well as artificial, natural, and synthetic fruit flavors such as apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, watermelon, apricot, banana, melon, apricot, plum, cherry, raspberry, blackberry, tropical fruits, mango, mangosteen, pomegranate, and papaya.Other potential flavors include milk, butter, cheese, cream, and yogurt; vanilla; tea or coffee flavors, e.g., green tea, oolong tea, black tea, cocoa, chocolate, and coffee; mint flavors, e.g., peppermint, spearmint, Japanese mint; spicy flavors, e.g., asafoetida, ayowan, anise, angelica, fennel, allspice, cinnamon, chamomile, mustard, cardamom, caraway, cumin, clove, pepper, coriander, sassafras, savory, and sansho (Japanese pepper). Flavorings include fructus, shiso, juniper berry, ginger, star anise, horseradish, thyme, tarragon, dill, bell pepper, nutmeg, basil, marjoram, rosemary, bay leaf, and wasabi (Japanese horseradish); alcoholic flavors such as wine, whiskey, brandy, rum, gin, and liqueur; floral flavors; and vegetable flavors such as onion, garlic, cabbage, carrot, celery, mushroom, and tomato. These flavorings may be used in liquid or solid form, individually or in combination. Commonly used flavors, whether used individually or in combination, include mints such as peppermint, menthol, and spearmint, artificial vanilla, cinnamon derivatives, and various fruit flavors. Additionally, when used in combination with refrigerants, flavors may provide breath-freshening properties, particularly minty flavors.

[0123] Furthermore, when used in combination with a coolant, the flavor may provide breath-freshening properties, particularly a minty flavor. These flavorings may be used in liquid or solid form, individually or in combination. Other useful flavorings include aldehydes and esters such as cinnamyl acetate, cinnamaldehyde, citral diethyl acetal, dihydrocarbyl acetate, eugenyl formate, and p-methylamizole, which may be used. In general, any flavoring or food additive, such as those listed in Chemicals Used in Food Processing, publication 1274, pp. 63-258, by the National Academy of Sciences, may be used.

[0124] Further examples of aldehyde flavorings include acetaldehyde (apple), benzaldehyde (cherry, almond), anisaldehyde (licorice, anise), cinnamaldehyde (cinnamon), citral, i.e., α-citral (lemon, lime), neral, i.e., β-citral (lemon, lime), decanal (orange, lemon), ethyl vanillin (vanilla, cream), heliotrope, i.e., piperonal (vanilla, cream), vanillin (vanilla, cream), α-amyl cinnamaldehyde (spicy fruity flavor), butyraldehyde (butter, cheese), and varellealdehyde (butter, cheese). Examples of flavorings include, but are not limited to, citronellal (modified, many types), decanal (citrus), aldehyde C-8 (citrus), aldehyde C-9 (citrus), aldehyde C-12 (citrus), 2-ethylbutyraldehyde (berries), hexenal, i.e., trans-2 (berries), tollaldehyde (cherries, almonds), veratrolaldehyde (vanilla), 2,6-dimethyl-5-heptenal, i.e., melonal (melon), 2,6-dimethyloctanal (green fruits), and 2-dodecenal (citrus, mandarin), cherry, grape, strawberry shortcake, and mixtures thereof. This list of flavorings is illustrative and not intended to limit the term “flavoring” or the scope of this disclosure in general.

[0125] Flavored products may be any flavored products according to the embodiments and models described below. In some embodiments, flavored products are beverage products such as fortified sparkling drinks, cola, lemon-lime flavored sparkling drinks, orange flavored sparkling drinks, grape flavored sparkling drinks, strawberry flavored sparkling drinks, pineapple flavored sparkling drinks, ginger ale, root beer, fruit juices, fruit-flavored juices, juice drinks, nectars, vegetable juices, vegetable-flavored juices, sports drinks, energy drinks, fortified water drinks, vitamin-fortified water, near-water drinks, coconut water, tea-type drinks, coffee, cocoa drinks, beverages containing dairy ingredients, beverages containing cereal extracts, and smoothies. In some other embodiments, flavored products are food products such as packaged foods, canned foods, and meal replacements. In some embodiments, flavored products are oral care products such as toothpaste, mouthwash, or teeth whitening compositions, such as the composition disclosed in U.S. Patent Application Publication No. 2019 / 0167545, which is incorporated herein by reference.

[0126] In embodiments where the flavored product is a beverage, the beverage may be selected from the group consisting of fortified sparkling beverages, cola, lemon-lime flavored sparkling beverages, orange flavored sparkling beverages, grape flavored sparkling beverages, strawberry flavored sparkling beverages, pineapple flavored sparkling beverages, ginger ale, root beer, fruit juice, fruit-flavored juice, juice drink, nectar, vegetable juice, vegetable-flavored juice, sports drink, energy drink, fortified water drink, vitamin-fortified water, near-water drink, coconut water, tea-type drink, coffee, cocoa drink, beverage containing dairy ingredients, beverage containing cereal extract, and smoothie. In some embodiments, the beverage may be a soft drink.

[0127] Flavored products can be in any suitable physical form. For example, in some embodiments, the flavored product may be in a solid form such as a powder. In further such embodiments, the flavored product is a toothpaste, such as toothpaste for whitening teeth and removing stains (e.g., tobacco tar). In some other embodiments, the flavored product may be a paste or slurry, such as toothpaste. In some other embodiments, the flavored product may be in the form of a cream or gel, such as a tooth gel, skin cream, or tooth cream. In some other embodiments, the flavored product may be a liquid suspension or solution, for example, containing an aqueous carrier. In some embodiments, the flavored product may be in the form of an emulsion, such as a microemulsion or nanoemulsion, which may contain surfactants, emulsifiers, etc. In some embodiments, the flavored product is a personal care product, such as a product for application to the skin, face, lips, gums, mouth, etc. Such a personal product may be for any suitable use, such as skin whitening or teeth whitening.

[0128] In some embodiments, the flavored product is an oral care product. “Oral care product” means a personal care product or other product that, in the course of normal use, is held in the oral cavity for a sufficient time to come into contact with substantially all tooth surfaces and / or oral tissues for the purpose of oral activity, rather than being intentionally swallowed for the purpose of systemic administration of a particular therapeutic agent. Oral care compositions can be in various forms, including toothpaste, toothpaste, toothpaste, tooth gel, subgingival gel, mouth rinse, mousse, foam, mouth spray, lozenges, chewable tablets, chewing gum, or denture products. Oral care compositions may also be incorporated into strips or films for direct application to or adhesion to oral surfaces.

[0129] In some embodiments, the flavored product is a pharmaceutical product, such as a product designed to carry or deliver a specific active pharmaceutical ingredient (API). Such APIs may be over-the-counter (OTC) drugs, such as acetaminophen and other OTC cough and cold medicines. In some embodiments, the API is a prescription-based drug.

[0130] In any aspect and specific embodiment of the embodiments described herein, a flavored product is a product that does not exist naturally, such as a packaged food or beverage product.

[0131] Further, non-limiting examples of food and beverage products or formulations include sweet coatings, frostings or glazes for any entity that falls under the categories of soups, dried processed foods, beverages, ready meals, canned or preserved foods, frozen processed foods, chilled processed foods, snack foods, baked goods, confectionery, dairy products, ice cream, meal replacements, pasta and noodle products, as well as sauces, dressings, condiments, baby food, and / or spreads.

[0132] Generally, the soup category refers to canned / preserved, dehydrated, instant, chilled, UHT, and frozen soups. For the purposes of this definition, soup means a food prepared from meat, poultry, fish, vegetables, grains, fruits, and other raw material ingredients, cooked in a liquid which may contain some or all visible parts of those raw material ingredients. Soup may be clear (as broth) or thick (as chowder), smooth, pureed or lumpy, ready to serve, semi-condensed or condensed, served hot or cold, as an appetizer, as a main course, or as a snack between meals (to be drunk little by little like a beverage). Soup may be used as a raw material ingredient to cook other food ingredients, ranging from broths (consommé) to sauces (cream or cheese-based soups).

[0133] The Dehydrated Foods and Prepared Foods category typically means: (i) Cooking aid products, e.g., powders, granules, pastes, concentrated liquid products, e.g., compressed cubes, tablets, or concentrated bouillons, bouillons and bouillon-like products in powder or granular form, sold separately as finished products (regardless of technology); (ii) Meal solution products, e.g., dehydrated and freeze-dried soups, e.g., dehydrated soup mixes, dehydrated instant soups, dehydrated semi-cooked soups, ready-made dishes including pasta, potato and rice dishes, meals and single-serving dehydrated or room-temperature-stable preparations; (iii) Meal accompaniment products, e.g., seasonings, marinades, salad dressings, salad toppings, dips, breadcrumbs, batter mixes, storage-stable spreads, barbecue sauces, liquid recipe mixes, concentrates, sauces or sauce mixes, e.g., salad recipe mixes, sold separately as finished products or as ingredients in products, in dehydrated, liquid or frozen form.

[0134] The beverage category typically refers to beverages, beverage mixes, and concentrates, and includes, but is not limited to, carbonated and non-carbonated beverages, alcoholic and non-alcoholic beverages, ready-to-drink beverages, liquid concentrate formulations for making beverages such as soda, and dry powder beverage pre-mixes. The beverage category also includes alcoholic drinks, soft drinks, sports drinks, isotonic beverages, and hot drinks. Alcoholic beverages include, but are not limited to, beer, cider / berry, FAB, wine, and spirits. Soft drinks include carbonated drinks, e.g., cola and non-cola carbonated drinks; fruit juices, e.g., juices, nectars, juice drinks, and fruit-flavored drinks; bottled water, e.g., sparkling water, spring water, and purified water / table water; functional drinks, e.g., sports drinks, energy drinks, or elixir drinks, which may be carbonated or non-carbonated; and concentrates, e.g., ready-to-drink liquid and powder concentrates, but are not limited to these. Hot or cold drinks include, but are not limited to, coffee or iced coffee, such as freshly brewed, instant, and blended coffee; tea or iced tea, such as black tea, green tea, white tea, oolong tea, and flavored tea; and other drinks containing flavorings, malt, or plant-based powders, granules, blocks, or tablets mixed with milk or water.

[0135] The snack food category generally refers to any food that can be a light, informal meal, including but not limited to sweet snacks, savory snacks, and snack bars. Examples of snack foods include, but are not limited to, fruit snacks, chips / crisps, extruded snacks, tortillas / corn chips, popcorn, pretzels, nuts, and other sweet and savory snacks. Examples of snack bars include, but are not limited to, granola / muesli bars, breakfast bars, energy bars, fruit bars, and other snack bars.

[0136] The baked goods category generally refers to any edible product prepared in a manner that involves exposure to heat or excessive sunlight. Examples of baked goods include, but are not limited to, bread, buns, cookies, muffins, cereals, toaster pastries, pastries, waffles, tortillas, biscuits, pies, bagels, tarts, quiches, cakes, any baked food, and any combination thereof. Further examples include, but are not limited to, packaged / industrial bread, unpackaged / artisan bread, packaged / industrial cakes, unpackaged / artisan cakes, cookies, chocolate-coated biscuits, sandwich biscuits, filling biscuits, savory biscuits and crackers, bread substitutes, breakfast cereals, RTE cereals, family breakfast cereals, flakes, muesli, other cereals, children's breakfast cereals, and hot cereals.

[0137] The ice cream category generally refers to frozen desserts containing cream, sugar, and flavorings. Examples of ice cream include, but are not limited to, impulse ice cream; takeaway ice cream; frozen yogurt and artisanal ice cream; and soy, oat, bean (e.g., adzuki beans and mung beans) and rice-based ice cream. Further examples of ice cream include, but are not limited to, single-serving dairy ice cream, single-serving water ice cream, multi-pack dairy ice cream, multi-pack water ice cream, takeaway dairy ice cream, ice cream desserts, bulk ice cream, and takeaway water ice cream.

[0138] The confectionery category generally refers to sweet-tasting edible products. Examples of confectionery include, but are not limited to, candies, gelatin, chocolate confectionery, sugar candies, gum, and any combination products. Further examples include, but are not limited to, tablets, countlines, self-packaged / softlines, boxed assortments, standard boxed assortments, twist-wrapped miniatures, seasonal chocolates, chocolates with toys, alfajores, other chocolate confectionery, mints, standard mints, power mints, boiled sweets, lozenges, gum, jelly and chew, toffee, caramel and nougat, medicinal candies, lollipops, licorice, and other sugar candies.

[0139] The meal replacement category generally refers to any food product intended to replace a regular meal, particularly for people with health or fitness concerns. Examples of meal replacements include, but are not limited to, slimming products and fatigue drinks and products.

[0140] The ready meal category generally refers to any food that can be served as a meal without extensive cooking or processing. Ready meals include products in which manufacturers have added recipe "skills" to provide a high level of preparation, completion, and convenience. Examples of ready meals include, but are not limited to, canned / preserved, frozen, dried, and chilled ready meals; dinner mixes; frozen pizzas; chilled pizzas; and prepared salads.

[0141] Pasta and noodle categories include, but are not limited to, any pasta and / or noodles, including canned, dried, and chilled / fresh pasta; and plain, instant, chilled, frozen, and snack noodles.

[0142] The canned / preserved food category includes, but is not limited to, canned / preserved meat and meat products, fish / seafood, vegetables, tomatoes, beans, fruits, ready meals, soups, pasta, and other canned / preserved foods.

[0143] Frozen processed foods include, but are not limited to, frozen processed red meat, processed poultry, processed fish / seafood, processed vegetables, meat substitutes, processed potatoes, bakery products, desserts, ready meals, pizzas, soups, noodles, and other frozen foods.

[0144] The dried processed foods category includes, but is not limited to, rice, dessert mixes, dried ready meals, dehydrated soups, instant soups, dried pasta, plain noodles, and instant noodles. The chilled processed foods category includes, but is not limited to, chilled processed meats, processed fish / seafood products, lunch kits, fresh cut fruit, ready meals, pizzas, prepared salads, soups, fresh pasta, and noodles.

[0145] The sauces, dressings and condiments category includes, but is not limited to, tomato pastes and purees, bouillon / stock cubes, herbs and spices, monosodium glutamate (MSG), table sauces, soy-based sauces, pasta sauces, wet / cooking sauces, dry sauces / powder mixes, ketchup, mayonnaise, mustard, salad dressings, vinaigrettes, dips, pickle products, and other sauces, dressings and condiments.

[0146] Baby food categories include, but are not limited to, milk or soy-based formulations, as well as cooked, dried, and other baby foods.

[0147] The spread category includes, but is not limited to, jams and preserves, honey, chocolate spreads, nut-based spreads, and yeast-based spreads.

[0148] The dairy product category generally refers to edible products produced from mammalian milk. Examples of dairy products include, but are not limited to, dairy beverages, cheese, yogurt and sour milk drinks, and other dairy products. Further examples of dairy products include raw / low-temperature sterilized milk, whole raw / low-temperature sterilized milk, semi-skimmed milk / low-temperature sterilized milk, long-life / UHT milk, whole long-life / UHT milk, semi-skimmed long-life / UHT milk, fat-free long-life / UHT milk, goat milk, condensed milk / sugar-free condensed milk, plain condensed milk / sugar-free condensed milk, flavored, functional and other condensed milk, flavored milk beverages, flavored milk beverages consisting only of dairy products, flavored milk beverages with juice, soy milk, fermented dairy product drinks, coffee whitener, powdered milk, flavored powdered milk drinks, cream, processed cheese, spreadable processed cheese, non-spreadable processed cheese, unprocessed cheese, spreadable unprocessed cheese, hard cheese, packaged hard cheese, unpackaged hard cheese, plain yogurt / natural yogurt, flavored yogurt, fruit yogurt, probiotic yogurt, drinking yogurt, regular drinking yogurt, and probiotic drinking yogurt, but are not limited to these.

[0149] In some embodiments, the flavored product is one or more confectionery, chocolate candies, tablets, countlines, self-packaged / softlines, boxed assortments, standard boxed assortments, or twist-wrapped miniatures. Miniatures), seasonal chocolates, chocolates with toys, alfajores, other chocolate confections, mints, standard mints, power mints, boiled sweets, lozenges, gum, jelly and chew, toffee, caramel and nougat, medicinal candies, lollipops, licorice, other sugar confections, bread, packaged / industrial bread, unpackaged / artisan bread, pastries, cakes, packaged / industrial cakes, unpackaged / artisan cakes, cookies, chocolate-coated biscuits, sandwich biscuits, filling biscuits, savory biscuits and crackers, bread substitutes, breakfast cereals, RTE cereals, family breakfast cereals, flakes, muesli, other cereals, children's breakfast cereals, hot cereals, ice cream, impulse ice cream, single serving dairy ice cream, single serving water ice cream, multi-pack dairy ice cream, multi-pack water ice cream, Takeaway ice cream, takeaway dairy ice cream, ice cream desserts, bulk ice cream, takeaway water ice cream, frozen yogurt, artisan ice cream, dairy products, milk, raw milk / pasteurized milk, whole raw milk / pasteurized milk, semi-skimmed milk / pasteurized milk, long-life / UHT milk, whole long-life / UHT milk, semi-skimmed long-life / UHT milk, non-fat long-life / UHT milk, goat milk, condensed milk / unsweetened condensed milk, plain condensed milk / unsweetened condensed milk, flavored, functional and other condensed milk, flavored milk drinks, dairy-only flavored milk drinks, fruit juice flavored milk drinks, soy milk, sour milk drinks, fermented dairy drinks, coffee whitener, powdered milk, flavored powdered milk drinks, cream, cheese, processed cheese, spreadable processed cheese, unspreadable processed cheese, unprocessed cheese, spreadable unprocessed cheese, hard cheese, packaged hard cheese, unpackaged hard cheese, yogurt,Plain yogurt / natural yogurt, flavored yogurt, fruit yogurt, probiotic yogurt, drinking yogurt, regular drinking yogurt, probiotic drinking yogurt, chilled storage stable desserts, dairy-based desserts, soy-based desserts, chilled snacks, fromage frais and quark, plain fromage frais and quark, flavored fromage frais and quark, savory fromage frais and quark, sweet and savory snacks, fruit snacks, chips / crisps, extruded snacks, tortillas / corn chips, popcorn, pretzels, nuts, other sweet and savory snacks, snack bars, granola bars, breakfast bars, energy bars, fruit bars, other snack bars, meal replacements, slimming products, fatigue drinks, ready meals, canned ready meals, frozen ready meals, dried ready meals, chilled ready meals, dinner mixes, chilled pizzas, soups, canned soups, dehydrated soups, instant soups, chilled soups, hot soups, frozen soups, pasta, canned pasta, dried Dried pasta, chilled / fresh pasta, noodles, plain noodles, instant noodles, cup / bowl instant noodles, pouch instant noodles, chilled noodles, snack noodles, canned foods, canned meat and meat products, canned fish / seafood, canned vegetables, canned tomatoes, canned beans, canned fruit, canned ready meals, canned soups, canned pasta, other canned foods, frozen foods, frozen processed red meat, frozen processed poultry, frozen processed fish / seafood, frozen processed vegetables, frozen meat substitutes, frozen potatoes, oven-baked potato chips, other oven-baked potato products, non-oven frozen potatoes, frozen bakery products, frozen desserts Frozen ready meals, frozen pizza, frozen soup, frozen noodles, other frozen foods, dried foods, dessert mixes, dried ready meals, dehydrated soup, instant soup, dried pasta, plain noodles, instant noodles, cup / bowl instant noodles, pouch instant noodles, chilled foods, chilled processed meat, chilled fish / seafood products, chilled processed fish, chilled coated fish, chilled smoked fish, chilled lunch kits, chilled ready meals, chilled pizza, chilled soup, chilled / fresh pasta, chilled noodles, oils and fats, olive oil, vegetable seed oil, cooking oils and fats, butter, margarine, spreadable oils and fats,Functional spread fats, oils, sauces, dressings and seasonings, tomato paste and purée, bouillon / stock cubes, gravy granules, liquid stock and fonds, herbs and spices, fermented sauces, soy-based sauces, pasta sauces, wet sauces, dry sauces / powder mixes, ketchup, mayonnaise, regular mayonnaise, mustard, salad dressings, regular salad dressings, low-fat salad dressings, vinaigrettes, dips, pickled products, other sauces, dressings and seasonings, baby foods, infant formulas, standard infant formulas, follow-on infant formulas, toddler formulas, hypoallergenic infant formulas, prepared baby foods, dried baby foods, other baby foods, spreads, jams and preserves, honey, chocolate spreads, nut-based spreads, and yeast-based spreads.

[0150] Some embodiments provide chewable flavored products that may or may not be intended to be swallowed. In some embodiments, the chewable flavored products can be gums, chewing gums, sugar gums, sugar-free gums, functional gums, bubble gums that individually or in combination include the compounds disclosed and described herein.

[0151] In some embodiments of any of the foregoing embodiments, the liquid composition may be included in a body care product such as a product suitable for application to human hair or skin. Accordingly, the consumer products of the present disclosure can be body care products, typically cosmetics, skin care products, or hair care products.

[0152] In some embodiments, a body care product includes one or more fragrances. In some embodiments, at least a portion of the fragrance can be encapsulated. A suitable fragrance comprises a complex mixture of fragrance compounds selected to provide any desired scent. In the context of this disclosure, the term “fragrance” is used synonymously with “fragrance.” Fragrance compounds typically used in the field of cosmetics and suitable for the purposes of this disclosure are fully described in S. Arctander, PERFUME FLAVORS AND CHEMICALS, Vols. I and II (1969), and THE MERCK INDEX, 8th edition, Merck & Co., Inc. Rahway, NJ. The term “fragrance compound” includes naturally occurring materials, as well as synthetic materials known to be used in fragrances, and animal oils. A fragrance compound may be any natural oil or extract, or a chemical compound, used in a fragrance composition. Natural oils and extracts, as described in Guenther, THE ESSENTIAL OILS 1949, may include extracts, presses, exudates, and distillates from any part of a suitable plant: roots, rhizomes, bulbs, corms, stems, bark, heartwood, leaves, flowers, seeds, and fruits. Examples of such extracts and distillates include citrus fruit oils such as orange, mandarin, grapefruit, lime, or lemon oil; tree oils such as pine or cedarwood oil; herbal oils such as peppermint, thyme, lavender, basil, rosemary, and clove oil; or floral extracts such as rose, jasmine, lily of the valley, or geranium oil.

[0153] Further non-exclusive examples of suitable fragrances include natural oils or naturally derived materials, as well as synthetic fragrances such as hydrocarbons, alcohols, aldehydes, ketones, esters, lactones, ethers, nitriles, and polyfunctionals. Non-exclusive examples of natural oils include: basil (sweet basil (Ocimum basilicum)) oil, bay (Pimento acris) oil, bee balm (Monarda didyma) oil, bergamot (Citrus aurantium bergamia) oil, cardamom (Elettaria cardamomum) oil, cedarwood (Atlas cedar (Cedrus atlantica)) oil, chamomile (Roman chamomile (Anthemis nobilis)) oil, cinnamon (Cinnamomum cassia) oil, citronella (Cymbopogon nardus) oil, clary (Clary sage (Salvia sclarea)) oil, and clove (Eugenia) oil. Caryophyllus oil, clove leaf oil (Eufenia caryophyllus), Cyperus esculentus oil, cypress oil (Cupressus sempervirens), eucalyptus citriodora oil, geranium maculatum oil, ginger oil (Zingiber officinale), grapefruit oil (Citrus grandis), hazelnut oil (Corylus avellana), jasmine oil (Jasminum officinale), juniperus communis oil, cadet juniper tar (Juniperus oxycedrus), pencil juniper virginiana) oil, kiwi (Actinidia chinensis) water, lavandin (Lavandula(hybrid) oil, lavender (Lavandula angustifolia) oil, lavender (Lavandula angustifolia) water, lemon (Citrus medica limonum) oil, lemongrass (Cymbopogon schoenanthus) oil, lime (Citrus aurantifolia) oil, linden (Tilia cordata) oil, linden (Tilia cordata) water, mandarin orange (Citrus nobilis) oil, nutmeg (Myristica fragrans) oil, orange (Citrus aurantium dulcis) flower oil, orange (Citrus aurantium dulcis) oil, orange (Citrus aurantium Dulcis water, patchouli (Pogostemon cablin) oil, peppermint (Menthe piperita) oil, peppermint (Menthe peperita) water, rosemary (Rosmarinus officinalis) oil, rose oil, rose (Rosa damascena) extract, rose (Rosa multiflora) extract, rosewood (Aniba rosaeodora) extract, sage (Salvia officinalis) oil, sandalwood (Santalum album) oil, spearmint (Menthe viridis) oil, tea tree (Melaleuca alternifolia) oil, and ylang-ylang (CanangaOdorata oil. Some non-limiting examples of synthetic hydrocarbon fragrances include caryophyllene, β-farnesene, limonene, α-pinene, and β-pinene. Some non-limiting examples of synthetic alcohol fragrances include bacdanol, citronellol, linalool, phenethyl alcohol, and α-terpineol. Some non-limiting examples of synthetic aldehyde fragrances include 2-methylundecanal, citral, hexyl cinnamic aldehyde, isocyclocitral, lilial, and 10-undecenal. Some non-limiting examples of synthetic ketone fragrances include cashmeran, α-ionone, isocyclone E, koavone, muscone, and tonalide. Some non-limiting examples of synthetic ester fragrances include benzyl acetate, 4-t-butylcyclohexyl acetate (cis and trans), cedyl acetate, cyclacet, isobornyl acetate, and terpinyl α-acetate (R=acetyl). Some non-limiting examples of synthetic lactone fragrances include coumarin, jasmine lactone, muscalactone, and peach aldehyde. Some non-limiting examples of synthetic ether fragrances include ambroxane, anther, and galaxolide. Some non-limiting examples of synthetic nitrile fragrances include cinnamonitrile and gernonitrile. Finally, some non-limiting examples of synthetic polyfunctional fragrances include amyl salicylate, isoeugenol, hedione, heliotropin, liral, and vanillin.

[0154] In some embodiments, a body care product may contain one or more ingredients that provide beneficial effects for hair care or skin care, such as compounds having antioxidant activity. For example, in some embodiments, a body care product may contain ascorbic acid, also known as vitamin C, an essential nutrient having antioxidant activity. In some embodiments, a body care composition may contain vitamin E, which refers to eight structurally related antioxidant compounds that exhibit radical scavenging activity. The compounds may include four tocopherol compounds and four tocotrienol compounds. In some embodiments, a body care product may contain resveratrol, an antioxidant compound naturally present in grape skins. In some embodiments, a body care product may contain certain oligopeptides, such as acetyl hexapeptide-8 (also known as acetyl hexapeptide-3), a synthetic peptide that reduces wrinkles. Various other such compounds may also be included, such as retinol, niacinamide, coenzyme Q10, and various polyphenols, such as flavonoids like catechins. These active ingredients may be used in amounts typical of their use in other body care products.

[0155] Body care products may include any suitable type of vehicle and carrier. Generally, the vehicle or carrier is any dermatologically acceptable vehicle or carrier. Non-limiting examples of vehicles or carriers include water, glycerin, alcohol, oil, silicon-containing compounds, silicone compounds, and waxes. Variants and other suitable vehicles will be apparent to those skilled in the art and are suitable for use in the body care products of this disclosure. In particular embodiments, the concentrations and combinations of compounds, ingredients, and agents may be selected so that the combination is chemically compatible and does not form complexes that precipitate from the finished body care product.

[0156] The body care products disclosed herein can be constructed or formulated in a variety of different forms. Non-limiting examples include emulsions (e.g., water-in-oil, water-in-oil-in-water, oil-in-water, silicone-in-water, water-in-silicone, oil-in-water, and silicone-in-oil-in-water emulsions), creams, lotions, solutions (e.g., aqueous or aqueous-alcoholic), anhydrous bases (e.g., lipsticks and powders), gels, masks, scrubs, body butters, peels, and ointments. Variations and other structures will be apparent to those skilled in the art and are suitable for use in the body care products of this disclosure.

[0157] A wide variety of other ingredients may be used, including those typically used in cosmetics, skincare products, or haircare products. The CTFA International Cosmetic Ingredient Dictionary and Handbook (2004 and 2008) lists a wide variety of non-exclusive ingredients that may be used in body care products.Examples of these ingredient classes include: fragrances (artificial and natural; e.g., gluconic acid, phenoxyethanol, and triethanolamine), dyes and coloring agents (e.g., Blue 1, Blue 1 Lake, Red 40, titanium dioxide, D&C Blue 4, D&C Green 5, D&C Orange 4, D&C Red 17, D&C Red 33, D&C Violet 2, D&C Yellow 10, and D&C Yellow 11), flavorings or fragrances (e.g., Stevia rebaudiana). Rebaudiana (sweet leaf) extract and menthol), adsorbents, lubricants, solvents, humectants (e.g., emollients, wetting agents, film-forming agents, occlusive agents, and agents that affect the skin's natural moisturizing mechanism), water repellents, UV absorbers (physical and chemical absorbents such as para-aminobenzoic acid ("PABA") and corresponding PABA derivatives, titanium dioxide, zinc oxide), essential oils, vitamins (e.g., B, D, E, and K), trace metals (e.g., zinc, calcium, and selenium), anti-irritants (e.g., steroids and non-steroidal anti-inflammatory drugs), plant extracts (e.g., aloe vera, chamomile, cucumber extract, ginkgo biloba extract, etc.) Biloba, ginseng, and rosemary, antimicrobial agents, antioxidants (e.g., BHT and tocopherol), chelating agents (e.g., disodium EDTA and tetrasodium EDTA), preservatives (e.g., methylparaben and propylparaben), pH adjusters (e.g., sodium hydroxide and citric acid), absorbents (e.g., aluminum starch octenyl succinate, kaolin, corn starch, oat starch, cyclodextrin, talc, and zeolite), skin bleaching and whitening agents (e.g., (For example, hydroquinone and niacinamido lactate), humectants (e.g., sorbitol, urea, methyl gluceth-20, isomerized sugar, and mannitol), exfoliants, waterproofing agents (e.g., magnesium hydroxide / aluminum stearate), skin conditioning agents (e.g., aloe extract, allantoin, bisabolol, ceramide, dimethicone, hyaluronic acid, biosaccharide gum-1, ethylhexylglycerin, pentylene glycol, hydrogenated polydecene, octyldodecyl oleate, and dipotassium glycyrrhizinate).Some further, non-limiting examples of these components are provided in the following subsections.

[0158] In some embodiments, a body care product includes one or more UV absorbers or UV reflectors. Suitable UV absorbers or UV reflectors include chemical sunscreens and physical sunscreens. Non-exclusive examples of chemical sunscreens include para-aminobenzoic acid (PABA), PABA esters (glyceryl PABA, amyldimethyl PABA, and octyldimethyl PABA), butyl PABA, ethyl PABA, ethyl dihydroxypropyl PABA, benzophenones (oxybenzone, surisobenzone, benzophenone, and benzophenone-1 to 12), cinnamates (octyl methoxycinnamate (octinoxate), isoamyl p-methoxycinnamate, octyl methoxycinnamate, cinoxate, diisopropylmethyl cinnamate, DEA-methoxycinnamate, ethyldiisopropyl cinnamate, glyceryl octanoate dimethoxycinnamate, and ethyl methoxycinnamate), cinnamate esters, salicylates (homomethyl salicylate, benzyl salicylate, glycol salicylate, isopropylbenzyl salicylate, etc.), anthranilates, and urocanin. Examples include ethyl acid, homosalate, octisalate, dibenzoylmethane derivatives (e.g., avobenzone), octocrylene, octyltriazone, digalloyltrioleate, glyceryl aminobenzoate, lausone and dihydroxyacetone, ethylhexyltriazone, dioctylbutamidotriazone, benzylidenemalonate polysiloxane, terephthalylidene dicamphor sulfonic acid, phenyldibenzimidazole tetrasulfonate disodium, diethylaminohydroxybenzoylhexylbenzoate, bis-diethylaminohydroxybenzoylbenzoate, bis-benzoxazoylphenylethylhexyliminotriazine, drometrizole trisiloxane, methylenebis-benzotriazolyltetramethylbutylphenol, and bis-ethylhexyloxyphenol methoxyphenyltriazine, 4-methylbenzylidene camphor, and isopentyl 4-methoxycinnamate. Non-exclusive examples of physical sunscreens include, but are not limited to, kaolin, talc, petrolatum, and metal oxides (e.g., titanium dioxide and zinc oxide).

[0159] In some embodiments, the body care product includes one or more moisturizers. Non-limiting examples of moisturizers that may be used include amino acids, chondroitin sulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerol polymer, glycol, 1,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factors, PEG-15 butanediol, polyglyceryl sorbitol, pyrrolidone carboxylic acid salts, PCA potassium, propylene glycol, isomerized sugar, sodium glucuronate, PCA sodium, sorbitol, sucrose, trehalose, urea, and xylitol. Other non-limiting examples include acetylated lanolin, acetylated lanolin alcohol, alanine, aloe extract, aloe barbadensis, aloe barbadensis extract, aloe barbadensis gel, Althea officinalis extract, apricot kernel oil, arginine, arginine aspartate, Arnica montana extract, aspartic acid, avocado oil, variol sphingolipids, butyl alcohol, beeswax, behenyl alcohol, β-sitosterol, birch bark extract, borage extract, butcher's broom (Ruscus) Aculeatus extract, butylene glycol, Calendula officinalis extract, Calendula officinalis oil, Candelilla (Euphorbia cerifera) wax, Canola oil, Caprylic / capric triglyceride, Cardamom (Elettaria cardamomum) oil, Carnauba (Copernicia cerifera) wax, Carrot (Daucus carota)Sativa oil, castor oil (Ricinus communis), ceramide, ceresin, ceteareth-5, ceteareth-12, ceteareth-20, cetearyl octanoate, ceteth-20, ceteth-24, cetyl acetate, cetyl octanoate, cetyl palmitate, chamomile (Anthemis nobilis)) oil, cholesterol, cholesterol ester, cholesteryl hydroxystearate, citric acid, clary (Salvia sclarea) oil, cocoa (Theobroma cacao) butter, caprylic / capric acid, coconut oil (Cocos nucifera), collagen, collagen amino acids, corn (Zea Mays) oil, fatty acids, decyl oleate, dimethicone copolyol, dimethiconol, dioctyl adipate, dioctyl succinate, hexa(caprylic / capric acid) dipentaerythrityl, DNA, erythritol, ethoxydiglycol, ethyl linoleate, eucalyptus globulus oil, evening primrose (Oenothera biennis) oil, fatty acids, Geranium maculatum maculatum) oil, glucosamine, glucose glutamate, glutamic acid, glycereth-26, glycerin, glycerol, glyceryl distearate, glyceryl hydroxystearate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl stearate, glyceryl stearate SE, glycine, glycol stearate, glycol stearate SE, glycosaminoglycan, grape (Vitis vinifera) seed oil, hazelnut (Corylus americana) nut oil, hazelnut (Corylus avellana) nut oil, hexylene glycol, hyaluronic acid, hybrid safflower (Carthamus)Ingredients: Castor oil, hydrogenated castor oil, hydrogenated cocoglycerides, hydrogenated coconut oil, hydrogenated lanolin, hydrogenated lecithin, hydrogenated palm glycerides, hydrogenated palm kernel oil, hydrogenated soybean oil, hydrogenated animal fat glycerides, hydrogenated vegetable oil, hydrolyzed collagen, hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed keratin, hydrolyzed soy protein, hydroxylated lanolin, hydroxyproline, isocetyl stearate, isocetyl stearoyl stearate, isodecyl oleate, isopropyl isostearate, isopropyl lanolinate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearamide DEA, isostearic acid, isostearyl lactate, isostearyl neopentanoate, jasmine (Jasminum officinale) oil, jojoba (Buxus chinensis) oil (Chinensis) oil, kelp, kukui (Aleurites moluccana) nut oil, lactamide MEA, lanes-16, lanes-10 acetate, lanolin, lanolin acid, lanolin alcohol, lanolin oil, lanolin wax, lavender (Lavandula angustifolia) oil, lecithin, lemon (Citrus medica limonum) oil, linolenic acid, linolenic acid, macadamia (Macadamia ternifolia) nut oil, maltitol, matricaria (Chamomilla) Recutita) oil, methyl glucose sesquistearate, methylsilanol PCA, mineral oil, mink oil, Mortierella oil, myristyl lactate, myristyl myristate, myristyl propionate, neopentyl glycol (dicaprylic / dicapric acid), octyldodecanol, octyldodecyl myristate, octyldodecyl stearoyl stearate, octyl hydroxystearate, octyl palmitate, octyl salicylate, octyl stearate, oleic acid, olive (Olea europaea) oil, orange (Citrus aurantium dulcis) oil, palm (Elaeis guinea) oilPrunus guineensis (peach) oil, palmitic acid, pantethine, panthenol, panthenyl ethyl ether, paraffin, PCA, Prunus persica (flowering peach) kernel oil, Arachis hypogaea (peanut) oil, PEG-8 C12-18 esters, PEG-15 cocamine, PEG-150 distearate, PEG-60 glyceryl isostearate, PEG-5 glyceryl stearate, PEG-30 glyceryl stearate, PEG-7 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-20 methyl glucose sesquistearate, PEG-40 sorbitan peroleate, PEG-5 soybean sterols, PEG-10 soybean sterols, PEG-2 stearate, PEG-8 stearate, PEG-20 stearate, PEG-32 stearate, PEG-40 stearate, PEG-50 stearate, PEG-100 stearate, PEG-150 stearate, pentadecalactone, peppermint (Mentha Ingredients: Piperita oil, petrolatum, phospholipids, plankton extract, polyaminosaccharide condensate, polyglyceryl-3 diisostearate, polyquaternium-24, polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80, polysorbate 85, potassium myristate, potassium palmitate, propylene glycol, (dicaprylic / dicapric acid) propylene glycol, propylene glycol dioctanoate, propylene glycol diperargonate, propylene glycol laurate, propylene glycol stearate, propylene glycol stearate SE, PVP, pyridoxine dipalmitate, retinol, retinyl palmitate, rice (Oryza sativa) bran oil, RNA, rosemary (Rosmarinus officinalis) oil, rose oil, safflower (Carthamus) (Tinctorius) oil, sage (Salvia officinalis) oil, sandalwood (Santalum album) oil, serine, serum protein, sesame (Sesamum indicum) oil, shea butter (Butyrospermum)Ingredients: Silk powder, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, sodium palmitate, sodium PCA, sodium polyglutamate, soluble collagen, sorbitan laurate, sorbitan oleate, sorbitan palmitate, sorbitan sesquioleate, sorbitan stearate, sorbitol, soybean (Glycine soja) oil, sphingolipids, squalane, squalene, stearamide MEA stearate, stearic acid, stearoxene dimethicone, stearoxene trimethylsilane, stearyl alcohol, stearyl glycyrrhetinate, stearyl heptanoate, stearyl stearate, sunflower (Helianthus annuus) seed oil, sweet almond (Prunus amygdalus) Examples include dulcis oil, synthetic beeswax, tocopheryl acetate, tocopheryl linoleate, tribehenin, tridecyl neopentanoate, tridecyl stearate, triethanolamine, tristearin, urea, vegetable oil, water, wax, wheat (Triticum vulgare) germ oil, and ylang-ylang (Cananga odorata) oil.

[0160] In some embodiments, the body care product may include one or more antioxidants in addition to, or in combination with, those disclosed above. For example, in some embodiments, one or more of these additional antioxidants may be used in combination with ascorbic acid, vitamin E, or a combination thereof. Non-limiting examples of antioxidants that may be used include: acetylcysteine, ascorbic acid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanol pectinate, ascorbyl palmitate, ascorbyl stearate and other ascorbic acid derivatives, BHA, BHT, t-butylhydroquinone, cysteine, cysteine ​​HCl, diamylhydroquinone, di-t-butylhydroquinone, dicetylthiodipropionate, dioleyltocopherylmethylsilanol, disodium ascorbate sulfate, distearylthiodipropionate, ditridecylthiodipropionate, dodecyl gallate, erythorbic acid, ascorbic acid esters, ethyl ferulate, ferulic acid, gallic acid esters, hydroquinone, isooctylthioglycolate, kojic acid, magnesium ascorbate, magnesium ascorbyl phosphate, and methylsilanol ascorbate. Examples include natural plant-derived antioxidants such as green tea or grape seed extract, nordihydroguaiaretic acid, octyl gallate, phenylthioglycolic acid, potassium ascorbyl tocopheryl phosphate, potassium sulfite, propyl gallate, quinone, rosmarinic acid, sodium ascorbate, sodium bisulfite, sodium erythorbate, sodium metabisulfite, sodium sulfite, superoxide dismutase, sodium thioglycolate, sorbityl furfural, thiodiglycol, thiodiglycolamide, thiodiglycolic acid, thioglycolic acid, thiolactic acid, thiosalicylic acid, tocophereth-5, tocophereth-10, tocophereth-12, tocophereth-18, tocophereth-50, tocophersolan, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate, tocopheryl succinate, and tris(nonylphenyl) phosphite.

[0161] In some embodiments, a body care product may contain one or more structuring agents. In certain embodiments, the structuring agent helps to provide the composition with rheological properties that contribute to stability. In some embodiments, the structuring agent may also function as an emulsifier or surfactant. Non-limiting examples of structuring agents include stearic acid, palmitic acid, stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmitic acid, polyethylene glycol ether of stearyl alcohol having an average of about 1 to about 21 ethylene oxide units, polyethylene glycol ether of cetyl alcohol having an average of about 1 to about 5 ethylene oxide units, and mixtures thereof.

[0162] In some embodiments, the body care product includes one or more emulsifiers. Emulsifiers can reduce interphase tension and improve the formulation and stability of the emulsion. Emulsifiers may be nonionic, cationic, anionic, and zwitterionic emulsifiers. Non-limiting examples include glycerin esters, propylene glycol esters, polyethylene glycol fatty acid esters, polypropylene glycol fatty acid esters, sorbitol esters, sorbitan anhydride esters, carboxylic acid copolymers, glucose esters and ethers, ethoxylated ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene fatty acid ether phosphates, fatty acid amides, acyl lactylates, soaps, TEA stearates, DEA oleth-3 phosphates, polyethylene glycol 20 sorbitan monolaurate (polysorbate 20), polyethylene Examples include glycol-5 soybean sterols, steareth-2, steareth-20, steareth-21, ceteareth-20, cetearyl glucoside, cetearyl alcohol, C12-13 pareth-3, PPG-2 methyl glucose ether distearate, PPG-5-ceteth-20, bis-PEG / PPG-20 / 20 dimethicone, ceteth-10, polysorbate 80, cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, polysorbate 60, glyceryl stearate, PEG-100 stearate, arachidyl alcohol, arachidyl glucoside, and mixtures thereof.

[0163] In some embodiments, the body care product comprises one or more silicone-containing compounds. Non-limiting examples of silicone-containing compounds include any member of the family of polymer products whose molecular skeleton consists of alternating silicon and oxygen atoms with side groups bonded to silicon atoms. By varying the --Si--O--chain length, side groups, and crosslinking, silicones can be synthesized into a wide variety of materials. They can have varying consistencys, from liquids to gels and solids. Silicone-containing compounds suitable for use in the body care compositions disclosed herein include, but are not limited to, those generally known to those skilled in the art. Non-limiting examples include silicone oils (e.g., volatile and non-volatile oils), gels, and solids. In certain embodiments, the silicon-containing compound includes silicone oils such as polyorganosiloxanes. Non-limiting examples of polyorganosiloxanes include dimethicone, cyclomethicone, polysilicone-11, phenyltrimethicone, trimethylsilylamodimethicone, stearoxytrimethylsilane, or mixtures of these and other organosiloxane materials in any given ratio to achieve desired consistency and application properties depending on the intended application (e.g., to specific areas such as skin, hair, or eyes). "Volatile silicone oil" includes silicone oils with low heat of vaporization, such as silicone oils with less than about 50 cal / g. Non-limiting examples of volatile silicone oils include cyclomethicone; and low-viscosity dimethicones such as dimethicone with a viscosity of about 50 cst or less. Other non-limiting volatile silicone oils that may be used in the context of this disclosure are those available from manufacturers such as Dow Corning, General Electric, and SWS Silicones.

[0164] In some embodiments, a body care product comprises one or more exfoliants. Exfoliants contain components that remove dead skin cells from the outer surface of the skin. These agents may act through mechanical, chemical, or other means. Non-limiting examples of mechanical exfoliants include abrasives such as pumice, silica, cloth, paper, shells, beads, solid crystals, and solid polymers. Non-limiting examples of chemical exfoliants include acids and enzymatic exfoliants. Acids that can be used as exfoliants include, but are not limited to, glycolic acid, lactic acid, citric acid, α-hydroxy acids, and β-hydroxy acids. Other exfoliants known to those skilled in the art are also considered useful in the context of the body care compositions of this disclosure.

[0165] In some embodiments, a body care product may contain one or more essential oils. Essential oils include oils derived from herbs, flowers, trees, and other plants. Such oils typically exist as tiny droplets between plant cells and can be extracted by several methods known to those skilled in the art (e.g., steam distillation, enfleurage (e.g., extraction using fats), maceration, solvent extraction, or mechanical pressurization). These types of oils tend to evaporate when exposed to air (e.g., volatile oils). Essential oils are generally insoluble in water but soluble in alcohols, ethers, fixed oils (vegetable), and other organic solvents. Essential oils are typically named after the plant from which the oil is found. Non-limiting examples of essential oils that may be used in the context of the body care compositions of this disclosure include sesame oil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil, pimento berry oil, rose oil, anise oil, balsam oil, bergamot oil, rosewood oil, cedar oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, and furan oil. Examples include cinnamon oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lavender oil, lemon oil, lemongrass oil, lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, orange oil, patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine oil, rose otto oil, rosemary oil, sandalwood oil, spearmint oil, spikenard oil, vetiver oil, wintergreen oil, and ylang. Other essential oils known to those skilled in the art are also considered useful in the context of this disclosure.

[0166] In some embodiments, a body care product may contain one or more thickeners. Thickeners, including thickeners or gelling agents, include substances that increase the viscosity of the composition. Thickeners include those that increase the viscosity of the composition without substantially altering the effectiveness of the active ingredients in the composition. Thickeners can also improve the stability of the composition. Commonly used thickeners include hydrogenated polyisobutene, trihydroxystearin, ammonium acryloyldimethyltaurate / VP copolymer, or combinations thereof. Other non-limiting examples of additional thickeners that may be used include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums. Examples of carboxylic acid polymers include acrylic acid, substituted acrylic acid, and crosslinked compounds containing one or more monomers derived from salts and esters of these acrylic acid and substituted acrylic acid, where the crosslinking agent contains two or more carbon-carbon double bonds and is derived from a polyhydric alcohol. Examples of commercially available carboxylic acid polymers include carbomers, which are homopolymers of acrylic acid crosslinked with sucrose or pentaerythritol allyl ethers. Non-limiting examples of crosslinked polyacrylate polymers include cationic polymers and nonionic polymers. Non-limiting examples are described in U.S. Patent No. 5,100,660; U.S. Patent No. 4,849,484; U.S. Patent No. 4,835,206; U.S. Patent No. 4,628,078; and U.S. Patent No. 4,599,379. Non-limiting examples of polyacrylamide polymers (including nonionic polyacrylamide polymers, including substituted branched or unbranched polymers) include polyacrylamide, isoparaffin and laureth-7, acrylamide and substituted acrylamide with acrylic acid and substituted acrylic acid multiblock copolymers.Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is alkyl-substituted cellulose, which is formed by hydroxyalkylating (e.g., hydroxyethylation or hydroxypropylation) the hydroxyl groups of a cellulose polymer to form hydroxyalkylated cellulose, which is then further modified with C10-C30 linear or branched alkyl groups through ether linkages. Typically, these polymers are ethers of C10-C30 linear or branched alcohols and hydroxyalkyl cellulose. Other useful polysaccharides include scleroglucans, which contain linear chains of (1-3) linked glucose units with (1-6) linked glucose units every three units. Non-limiting examples of gums that may be used include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

[0167] In some embodiments, a body care product may contain one or more preservatives. Non-limiting examples of preservatives that may be used in the context of this disclosure include quaternary ammonium preservatives such as polyquaternium-1 and benzalkonium halides (e.g., benzalkonium chloride and benzalkonium bromide), parabens (e.g., methylparaben and propylparaben), phenoxyethanol, benzyl alcohol, chlorobutanol, phenol, sorbic acid, thimerosal, or combinations thereof.

[0168] In some embodiments, the body care product may contain one or more emollients. Some non-limiting examples of suitable emollients include: (a) silicone oils and their modifications, e.g., linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl, and aryl silicone oils; (b) oils and fats including jojoba oil, soybean oil, sunflower oil, rice bran oil, avocado oil, almond oil, olive oil, sesame oil, apricot kernel oil, castor oil, coconut oil, mink oil; cocoa butter; natural oils and fats such as beef tallow and lard; hydrogenated oils obtained by hydrogenating the above oils; and synthetic mono, di, and triglycerides such as myristic acid glyceride and 2-ethylhexanoic acid glyceride; (c) waxes such as carnauba, whale wax, beeswax, lanolin, and their derivatives; (d) hydrophobic plant extracts; (e) hydrocarbons such as liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, pristane, and mineral oil; (f) lauan (g) Higher fatty acids such as phosphoric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid, arachidonic acid, and polyunsaturated fatty acids (PUFAs); (h) Higher alcohols such as lauryl, cetyl, stearyl, oleyl, behenyl, cholesterol, and 2-hexydecanol alcohol; (h) Esters such as cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glycerol monostearate, glycerol distearate, glycerol tristearate, alkyl lactate, alkyl citrate, and alkyl tartrate;(i) Peppermint, jasmine, camphor, sandalwood, bitter orange peel, lilac, turpentine, cinnamon, bergamot, Satsuma mandarin, calamus, pine, lavender, bay, clove, cypress, eucalyptus, lemon, starflower, thyme, peppermint, rose, sage, sesame, ginger, basil, juniper, lemongrass, rosemary, rosewood, avocado, grape, grape seed, myrrh, cucumber, watercress, calendula, elderflower, geranium, linden blossom, amaranth, seaweed, ginkgo, carrot, guarana, tea tree, jojoba, comfrey, oatmeal, cocoa, neroli, vanilla, green tea, pennyroyal, aloe vera, menthol, cineole, eugenol, citral, citronellol, borneol, linalool (i) Essential oils and extracts such as geraniol, evening primrose, camphor, thymol, spiranthol, penene, limonene, and terpenoid oils; (j) Lipids such as cholesterol, ceramide, sucrose esters, and pseudoceramides; (k) Vitamins A, E, and K; Vitamin alkyl esters including vitamin C alkyl ester; Vitamins, minerals, and skin nutrients such as magnesium, calcium, and milk; (l) Sunscreens such as octyl methoxyl cinnamate and butyl methoxybenzoylmethane; (l) Phospholipids; (m) Polyhydric alcohols such as glycerin and propylene glycol; and polyols such as polyethylene glycol; (n) Anti-aging compounds such as α-hydroxy acids and β-hydroxy acids; and (o) mixtures of any of the aforementioned components, etc.

[0169] In some embodiments, the body care product may include one or more tackifiers. Non-limiting examples of suitable tackifiers include aliphatic hydrocarbon resins, aromatic modified aliphatic hydrocarbon resins, hydrogenated polycyclopentadiene resins, polycyclopentadiene resins, gum rosin, gum rosin esters, wood rosin, wood rosin esters, tall oil rosin, tall oil rosin esters, polyterpenes, aromatic modified polyterpenes, terpene phenols, aromatic modified hydrogenated polycyclopentadiene resins, hydrogenated aliphatic resins, hydrogenated aliphatic aromatic resins, hydrogenated terpenes and modified terpenes, hydrogenated rosin acids, hydrogenated rosin esters, polyisoprene, partially or fully hydrogenated polyisoprene, polybutadiene, partially or fully hydrogenated polybutadiene, and the like. The tackifier is fully or partially hydrogenated. The tackifier may also be nonpolar, which means that the tackifier substantially does not contain monomers having polar groups. In some embodiments, no polar groups are present. In some embodiments, the polar groups are present in an amount of up to about 5 wt%, typically up to about 2 wt%, more typically up to about 0.5 wt%.

[0170] In some embodiments, the body care product may include one or more colorants such as pigments or dyes. Examples of suitable pigments include, but are not limited to, inorganic pigments, organic pigments, lakes, nacreous pigments, iridescent or optically variable pigments, and mixtures thereof. The term "pigment" is understood to mean inorganic or organic, white or colored particles. The pigments may optionally be surface-treated within the scope of the present disclosure, but are not limited to treatments such as silicones, perfluorinated compounds, lecithin, and amino acids.

[0171] In some embodiments, the body care product may include one or more surfactants. Surfactants useful as surfactant components in the compositions disclosed herein include nonionic, anionic, cationic, and amphoteric (zwitterionic) surfactants and may be used in combination with one another.

[0172] In some embodiments, the body care product may contain one or more pH adjusters. Examples of pH adjusters include inorganic and organic acids and bases, particularly aqueous ammonia, citric acid, phosphoric acid, acetic acid, sodium hydroxide, lactic acid, levulinic acid, glycolic acid, tartaric acid, malic acid, pyrrolidone carboxylic acid (PCA), succinic acid, citric acid, glutamic acid, 2-amino-2-methyl-1-propanol (AMP), and triethanolamine (TEA).

[0173] In some embodiments, the body care product may contain one or more reducing agents. Suitable reducing agents include, but are not limited to, thiourea, thiosulfates, sulfites, bisulfites, metabisulfites, borohydride salts, and hypophosphates (such as sodium salts), ascorbic acid and its salts, esters, and derivatives (e.g., ascorbyl palmitate and ascorbyl polypeptides), and tocopherol and its salts, esters, and derivatives (e.g., tocopherol acetate). Other well-known reducing agents, such as those listed in the INCI Handbook, may also be used.

[0174] In some embodiments, a body care product may contain one or more foaming agents. Examples of foaming agents include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-acyl amino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid esters, sucrose fatty acid esters, polyglycerin fatty acid esters, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, and polyoxyethylene fatty acid esters. These foaming agents can be used individually or in combination of two or more.

[0175] In some embodiments, a body care product may contain one or more sunscreens. Suitable sunscreens include, but are not limited to, α-hydroxyaldehydes and ketones, glyceraldehydes and related alcohol aldehydes, various indoles, imidazoles and their derivatives, and various approved pigments. Other suitable sunscreens include, but are not limited to, methylglyoxal, glycerolaldehyde, erythritolose, alloxane, 2,3-dihydroxysuccinialdehyde, 2,3-dimethoxysuccinialdehyde, 2-amino-3-hydroxysuccinialdehyde, and 2-benzylamino-3-hydroxysuccinialdehyde.

[0176] In some embodiments, a body care product may contain one or more astringents. Suitable astringents include, but are not limited to, aluminum citrate, aluminum lactate, birch extract, coffee extract, evening primrose extract, grape extract, henna extract, ivy extract, lemon extract, witch hazel extract, ammonium and potassium alum, aluminum triphosphate, aluminum glycinate and aluminum phenol sulfate, alcloxa, aldioxa, aluminum stearate, aluminum sulfate and aluminum citrate, sodium aluminum phosphate, sodium alum, sodium aluminum chlorohydroxylactate, calcium lactate, calcium chloride, calcium sulfate hydrate, sodium aluminum lactate, zinc acetate, zinc chloride, zinc sulfate, zinc lactate, zinc zeolite, zinc phenolsulfonate, and combinations thereof.

[0177] In some embodiments, a body care product may contain one or more preservatives. Suitable preservatives include, but are not limited to, methyl, ethyl, propyl, or butyl esters of p-oxybenzoic acid, phenoxyethanol, o-phenylphenol, dehydroacetic acid or its salts, p-cresol, m-cresol, o-chloro-m-xylenol, peppermint oil, echinacea, bloodroot, chili pepper, tea tree oil, cornflower, chaparral, stinging metal, bay, myrrh, rhatania bark, American pepper, calendula, chamomile, and mupirocine. Examples include neomycin sulfate, bacitracin, polymyxin B, 1-ofloxacin, tetracyclines (chlortetracycline hydrochloride, oxytetracycline hydrochloride, and tetracycline hydrochloride), clindamycin phosphate, gentamicin sulfate, benzalkonium chloride, benzethonium chloride, hexylresorcinol, methylbenzethonium chloride, phenol, quaternary ammonium compounds, triclocarbon, triclosan, and tea tree oil.

[0178] In some embodiments, a body care product may include one or more deodorants or antiperspirants. Suitable antiperspirants and deodorants include, but are not limited to, zinc salts such as zinc sulfate and zinc chloride, glycinates such as aluminum zirconium glycinate, aluminum chlorohydrate, aluminum zirconium tetrachlorohydrate, zinc carbonate, orthophenylphenol, and quaternary ammonium compounds such as dimethylbenzylammonium chloride and hexamethonium chloride.

[0179] In some embodiments, a body care product may contain one or more skin whitening agents. Examples of skin whitening agents include, but are not limited to, hydroquinone, kojic acid, licorice or its derivatives, ascorbic acid or its derivatives, arbutin, bearberry extract, Spanish licorice (Glycyrrhiza glabra) and its derivatives, Chlorella vulgaris extract, perilla extract, coconut fruit extract, and / or other depigmenting agents.

[0180] In some embodiments, a body care product contains one or more biocides. Examples of biocides include, but are not limited to, triclosan, 3,4,4'-trichlorocarbanilide (triclocarban); 3,4,4'-trifluoromethyl-4,4'-dichlorocarbanilide (cloflucarban); 5-chloro-2-methyl-4-isothiazolin-3-one; iodide propynyl butylcarbamate; 8-hydroxyquinoline; 8-hydroxyquinoline citrate; 8-hydroxyquinoline sulfate; 4-chloro-3,5-xylenol (chloroxylenol); 2-bromo-2-nitropropane-1,3-diol; diazolidinyl urea; butoconazole; nystatin; terconazole; nitrofurantoin; phenazopyridine; acyclovir; clotrimazole; chloroxylenol; chlorhexidine Examples include: miconazole; terconazole; butylparaben; ethylparaben; methylparaben; methylchloroisothiazoline; methylisothiazoline; mixtures of 1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin and 3-iodo-2-propynylbutylcarbamate; oxyquinoline; EDTA; tetrasodium EDTA; p-hydroxybenzoic acid esters; alkylpyridinium compounds; cocophosphatidyl PG-dimonium chloride; chlorhexidine gluconate; chlorhexidine digluconate; chlorhexidine acetate; chlorhexidine isethionate; chlorhexidine hydrochloride; benzalkonium chloride; benzethonium chloride; polyhexamethylene biguanide; and mixtures thereof.

[0181] Other ingredients typically used in body care products, such as skincare or haircare products, may also be included.

[0182] In some embodiments, the body care product is a shampoo, body wash, soap, exfoliating scrub, moisturizer, facial serum, antiperspirant, deodorant, body lotion, body oil, sunscreen, or bronzer.

[0183] In some embodiments, body care products are personal care products or cosmetics. Personal care products and cosmetics include products that can be applied to the skin, hair and nails as either leave-on products or rinse-off products. In the context of this disclosure, “rinse-off” means that the intended use of the product includes application to the skin and / or hair and subsequent rinsing or wiping off of the product from the skin or hair within a few seconds to a few minutes of the application process. Personal care products and cosmetics include powders, creams, emulsions, lotions, gels and oils, coloring bases (liquids and pastes) and liquid-impregnated tissues for skin (face, hands, feet, etc.); products for applying and removing makeup from the face and eyes; hair care products including hair colorants and bleachers; products for waving, straightening, setting and fixing hair; shaving products including creams, foams, mousses and depilatory products; sunbathing products and products for tanning without sun; and deodorant and antiperspirant products.

[0184] In some embodiments, personal care products or cosmetics are selected from the group consisting of shaving aids, shampoos, hair conditioner products, leave-on skincare products, skin cleansing or washing products (such as rinse-off skin cleansing or washing products), wet wipes and body sprays, deodorants or antiperspirants. Shaving aids specifically include foams, gels, creams, and bars (see, for example, U.S. Patent Nos. 7,069,658, 6,944,952, 6,594,904, 6,182,365, 6,185,822, 6,298,558, and 5,113,585). Shampoos and hair conditioners specifically include two-in-one shampoos and shampoos that are specifically formulated for dry or oily hair or that contain additives such as anti-dandruff agents. Hair conditioners may be rinse-off or leave-on hair conditioners, and also include hair tonics, bleaches, colorants, and setting and styling products. For example, one can refer to U.S. Patent Nos. 6,162,423, 5,968,286, 5,935,561, 5,932,203, 5,837,661, 5,776,443, 5,756,436, 5,661,118, and 5,618,523. Leave-on skincare products include eau de parfum, eau de toilette, cologne, wet wipes, body spray, deodorant, and antiperspirant. Skin cleansing products specifically include bar soaps, shower gels, liquid soaps, body washes, exfoliating gels, and pastes for cosmetic and hygiene purposes (see, for example, U.S. Patent No. 3,697,644; U.S. Patent No. 4,065,398; and U.S. Patent No. 4,387,040).Wet wipes specifically include skin cleansing wipes, baby wipes, makeup removal wipes, and skin refreshing wipes (see, for example, U.S. Patent No. 4,775,582; International Publication No. 02 / 07701; International Publication No. 2007 / 069214 and International Publication No. 95 / 16474). Body sprays, deodorants, and antiperspirants specifically include sticks, liquid roll-on applicators, and pressurized sprays.

[0185] The compositions and consumer products described herein are further illustrated by the following non-limiting examples.

[0186] Examples Unless otherwise specified, the percentages (%) and ratios shown in the examples are percentages by weight and weight ratio.

[0187] Example 1. Solvent Comparison Several solvents and solvent blends were prepared, and then measured amounts of naringenin were added and mechanically stirred. Each mixture was then visually observed for dissolution. The results are summarized in Table 1 below. All samples were stored at room temperature, protected from direct light, and their stability was re-evaluated after 3 months.

[0188] [Table 1]

[0189] Example 2. Exemplary Composition Examples of compositions according to some aspects of this disclosure are shown in Tables 2 and 3 below.

[0190] [Table 2]

[0191] [Table 3]

[0192] Example 3. Solubility of naringenin at 25°C Naringenin was mixed with different solvents and solvent mixtures and transferred to 8 mL vials equipped with an overhead stirrer. The samples were placed in a Crystalline PV instrument (Technobis, Netherlands). The heating process was carried out with a heating gradient of +0.1°C / min under mechanical stirring, and the samples were monitored by tracking transparency through an LED light beam passing through the vial. Full (100%) transparency was obtained when naringenin was completely dissolved in the solvent. On the other hand, if the transparency measurement was less than 100%, the dissolution process was still incomplete. Once a signal of 100% transparency was obtained, the dissolution process was completed, and each temperature was defined as the solubilization temperature.

[0193] For each solvent or mixture of solvents, the solubility measured as a function of temperature was fitted to an exponential function. The solubility at 25°C was obtained by extrapolating or interpolating this exponential function.

[0194] [Table 4]

[0195] Example 4: Solubility of phloretin at 25°C The solubility of phloretin at 25°C was determined using the same method as described in Example 3.

[0196] [Table 5]

[0197] Example 5. Stability of naringenin solution Naringenin was mixed with different solvents and heated until the product was completely dissolved. The samples were then cooled to room temperature and stored for three months.

[0198] [Table 6]

[0199] The disclosed subject matter is described with reference to specific details of its particular embodiments. Such details are not intended to be considered limitations on the scope of the disclosed subject matter, except to the extent that they are included in the appended claims.

[0200] Accordingly, the exemplary embodiments described herein are well adapted to achieve the purposes and benefits mentioned herein, as well as the purposes and benefits inherent to them. The exemplary embodiments described herein are merely illustrative, as they can be modified and implemented in ways that are clearly different but equivalent to those of a person skilled in the art who have an interest in the teachings herein. Furthermore, nothing is intended to limit the structural or design details shown herein except as described in the following claims. Accordingly, it is clear that the specific exemplary embodiments disclosed herein may be modified, combined or altered, and all such variations are considered to fall within the scope and spirit of the exemplary embodiments described herein. The exemplary embodiments described herein, as described herein, can be adequately implemented in the absence of any elements not specifically disclosed herein and / or any optional elements disclosed herein.

Claims

1. a) Compound of formula (I) 【Chemistry 1】 or its salt, in the formula, R １ These are hydrogen atoms, -OH or -O-R １Ａ And; R １Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R １Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R ２ These are hydrogen atoms, -OH or -O-R ２Ａ And; R ２Ａ is C optionally substituted one or more times by a substituent selected from the group consisting of -OH and C １～６ alkoxy, or R １～６ is alkyl, or R ２Ａ is an oligosaccharide moiety bonded by a glucuronyl moiety, a furanose moiety, a pyranose moiety, or a glycosidic bond and having 2 to 5 sugar moieties independently selected from the group consisting of a furanose moiety and a pyranose moiety; R ３ is -OH or -O-R ３Ａ And; R ３Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R ３Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R ４ These are hydrogen atoms, -OH or -O-R ４Ａ And; R ４Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R ４Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R ５ These are a hydrogen atom, -OH, -O-R ５Ａ or -O-C(O)-R ５Ｂ And; R ５Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R ５Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R ５Ｂ is -H, or -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ It is alkyl; R ６ and R ７ C is independent １～６ Alkyl, -OH, C １～６ Alkoxy and -O-(C １～６ Alkylene)-O-(C) １～６ Selected from the group consisting of alkyl; m is 0, 1 or 2; and n is 0, 1, 2, or 3; or Compound of formula (II) 【Chemistry 2】 or its salt, in the formula, R ８ These are hydrogen atoms, -OH or -O-R ８Ａ And; R ８Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R ８Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R ９ These are hydrogen atoms, -OH or -O-R ９Ａ And; R ９Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R ９Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R １０ is -OH or -O-R １０Ａ And; R １０Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R １０Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R １１ These are hydrogen atoms, -OH or -O-R １１Ａ And; R １１Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R １１Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R １２ These are a hydrogen atom, -OH, -O-R １２Ａ or -O-C(O)-R １２Ｂ And; R １２Ａ is -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ Alkyl or R １２Ａ This is an oligosaccharide moiety having a glucuronyl moiety, a furanose moiety, a pyranose moiety, or 2 to 5 sugar moieties independently selected from the group consisting of furanose moieties and pyranose moieties, linked by glycosidic bonds; R １２Ｂ is -H, or -OH and C １～６ C may be substituted one or more times with substituents selected from the group consisting of alkoxys. １～６ It is alkyl; R １３ and R １４ C is independent １～６ Alkyl, -OH, C １～６ Alkoxy and -O-(C １～６ Alkylene)-O-(C) １～６ Selected from the group consisting of alkyl; m' is 0, 1 or 2; and n' is 0, 1, 2, or 3; or a combination thereof; b) Oils containing carbonone; and c) Optionally, solvent Includes, A liquid composition in which the compound of formula (I) and / or (II) is present in an amount of at least 7% by weight of the total weight of the composition.

2. The liquid composition according to claim 1, which is a transparent and homogeneous solution.

3. The liquid composition according to claim 1 or 2, wherein the liquid composition comprises a compound of formula (I).

4. R ５ However, hydrogen atoms or -O-C(O)-R ５Ｂ And typically, R ５Ｂ However, C １～６ The liquid composition according to claim 3, wherein the component is alkyl.

5. R １ is -OH or -O-R １Ａ where R ２ is -OH or -O-R ２Ａ where R ３ is -OH or -O-R ３Ａ where R ４ is -OH or -O-R ４Ａ is 0, m is 0, and n is 0, the liquid composition according to claim 4.

6. The liquid composition according to claim 1 or 2, wherein the liquid composition comprises a compound of formula (II).

7. R １２ The liquid composition according to claim 6, wherein the atom is a hydrogen atom.

8. R ８ is -OH or -O-R ８Ａ where R ９ is -OH or -O-R ９Ａ where R １０ is -OH or -O-R １０Ａ where R １１ is -OH or -O-R １１Ａ The liquid composition according to claim 7, wherein m' is 0, n' is 0, and R is -OH or -O-R

9. The liquid composition according to any one of claims 1 to 8, wherein the oil containing carbonone is neat carbonone, spearmint oil, caraway seed oil, or dill oil.

10. A liquid composition according to any one of claims 1 to 9, comprising a solvent selected from the group consisting of 1-propanol, 2-propanol, ethanol, propylene glycol, triethyl citrate, triacetin, glycerol, 1,3-propanediol, ethyl lactate, and benzyl alcohol.

11. A consumer product comprising the liquid composition according to any one of claims 1 to 10.

12. The product comprises at least one cooling compound, the at least one cooling compound being typically (-)-menthol, N-ethyl-p-menthyl-3-carboxamide, cubebol, isopulegol, 3-(L-menthoxy)propane-1,2-diol, cis / trans-p-menthane-3,8-diol, 3-(L-menthoxy)-2-methylpropane-1,2-diol, 2-[2-(p-menthane-3-yloxy)ethoxy]ethanol, menthoxyethanol, (1R,2R,4R)-1-(2-hydroxy-4-methylcyclohexyl ) Ethenone, (1R,2R,5R)-N-ethyl-5-methyl-2-(propa-1-en-2-yl)-cyclohexanecarboxamide, N-(3-hydroxy-4-methoxyphenyl)-2-isopropyl-5,5-dimethyl-cyclohexanecarboxamide, N-[4-(cyanomethyl)phenyl]-2-isopropyl-5,5-dimethyl-cyclohexanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethyl-cyclohexane-1-carboxamide, L-menthol lactate, (-)- Menthyl ethylene glycol carbonate, (-)-menthone 1,2-glycerol ketal, D / L-menthone 1,2-glycerol ketal, (-)-menthyl 1-propylene glycol carbonate, (-)-menthyl 2-propylene glycol carbonate, D / L-menthyl 1-propylene glycol carbonate, D / L-menthyl 2-propylene glycol carbonate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide, menthyl ethylamide Xalate, (E)-3-benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide, 3,4-methylenedioxycinnamic acid, N,N-diphenylamide, N,N-dimethyl(-)-menthylsuccinimide, (1R,2S,5R)-N-(4-(carbamoylmethyl)phenyl)-menthylcarboxamide, (-)-menthylpyrrolidone carboxylate, L-phenylephrine p-menthanecarboxamide, (1R,2S,5R)-N-(4-(cyanomethyl)-phenyl)menthylcarboxamide, (1R,2S,5R)-N-(2-(pyridine-2-yl)ethyl)menthylcarboxamide, 6-isopropyl-3,9-dimethyl-1,4-dioxaspiro[4.5]decane-2-one, (1R,2R,4S)-dihydroumbellol, N-ethyl-p-menthane-3-carboxamide, 2-isopropyl-N,2,3-trimethylbutylamide, ethyl-3-(p-menthane-3-carboxamide)acetate, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-dimethylbutanamide, N-cyclopropyl A consumer product according to claim 11, selected from the group consisting of -5-methyl-2-isopropyl-cyclohexanecarbonecarboxamide, (-)-menthyl acetoacetate, (-)-menthyl succinate, (-)-menthyl(S)-3-hydroxybutyrate, (-)-menthyl glutarate, 1-[2-hydroxyphenyl]-4-[2-nitrophenyl]-1,2,3,6-tetrahydropyrimidine-2-one, di-(-)-menthyl glutarate, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, and any combination thereof.

13. The solution further comprises at least one cooling-enhancing compound, the at least one cooling-enhancing compound being typically N-ethyl-N-(thiophene-2-ylmethyl)-2-(p-tolyloxy)acetamide; N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide; 2-(4-fluorophenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-(2-hydroxy-4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide; 2-((2,3-dihydro-1H-inden-5-yl)oxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)-acetamide; 2-((2,3-dihydro-1H-inden-5-yl)oxy)-N-(1H-pyrazole-3-yl)-N-(thiazole-5-ylmethyl)acetamide; 5-methoxy-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)benzofuran-2-carboxamide; 2-(4-ethylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide; The consumer product according to claim 11 or 12, selected from the group consisting of (E / Z)-2-methyl-2-butenal; (E / Z)-2-isopropyl-5-methyl-2-hexenal; and any combination thereof.

14. A consumer product according to any one of claims 11 to 13, further comprising a sweetener.

15. A consumer product according to any one of claims 11 to 14, which is a flavored product, typically a food, beverage product, oral care product or pharmaceutical product, or a body care product, typically a cosmetic, skin care product or hair care product.

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