Vacuum Multi-Chamber Freeze Dryer

Abstract

By improving the water collection system and temperature control system, a vacuum multi-chamber freeze dryer is provided that is easy to operate and has high freeze-drying efficiency. [Solution] The vacuum multi-chamber freeze dryer comprises an apparatus body 20, at least one freeze-drying chamber 30, a water collection system 40, a temperature control system 50, and a pressure release system 60. The apparatus body has a positive pressure cabinet 21 and a water refilling area 22. The positive pressure cabinet is installed above the water refilling area. The positive pressure cabinet has an operation space 211. The operation space has at least one operation surface 215. The freeze-drying chambers are installed in the positive pressure cabinet. An opening and a chamber door corresponding to the opening are provided on the operation surface of each freeze-drying chamber. The water collection system includes a condensation chamber and a vacuum pump. The condensation chamber is installed in the apparatus body.

Description

[Technical field]

[0001] The present invention relates to a vacuum multi-chamber freeze dryer, and in particular to a freeze-drying device for drying samples, which has precise temperature control performance and a highly efficient water collection design, and meets the needs of pharmaceutical, food, biological products and other fields to remove moisture at low temperatures and maintain the activity or quality of the products. [Background technology]

[0002] Conventional freeze-drying technology freezes samples mainly by reducing pressure and low temperature, and then dries them by sublimating the water, and is widely used in fields such as pharmaceuticals, food preservation, and the chemical industry. However, conventional freeze-drying devices have the following disadvantages (1) and (2).

[0003] (1) Cross-contamination of samples: Conventionally available single-chamber freeze-drying devices (e.g., Patent Document 1 or Patent Document 2) process all samples in a single freeze-drying chamber, even if the inside of the freeze-drying chamber is single-layered or multi-layered, and lack an effective flow-division mechanism. Therefore, even when samples from different sources are processed simultaneously, they have no choice but to be placed in the same space, which increases the risk of cross-contamination between samples. In addition, since all samples are placed in the same vacuum environment, there is a risk that any misoperation or microbial contamination could adversely affect all samples, making it difficult to ensure the independence and safety of each sample.

[0004] (2) Unstable temperature control: In the freeze-drying process, if the temperature of the loading plate is not precisely controlled, it will directly affect the drying efficiency and quality of the sample. However, the heating speed of the temperature control device of some freeze-dryers is slow, making it difficult to precisely control the temperature, which leads to uneven freezing and drying of the sample, which may adversely affect the crystallinity and quality of the sample.

[0005] Conventional devices have the above-mentioned drawbacks and still have room for improvement in terms of operational efficiency and sample safety. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Taiwan Utility Model Registration No. M522329 [Patent Document 2] Japanese Patent No. 2676374 Summary of the Invention [Problem to be solved by the invention]

[0007] The objective of the present invention is to provide a freeze-drying device that is easy to operate and has high freeze-drying efficiency, in particular, a vacuum multi-chamber freeze-drying device that has an improved water collection system and temperature control system to provide easy to operate and high freeze-drying efficiency. [Means for solving the problem]

[0008] In order to solve the above problems, according to a first aspect of the present invention, there is provided a vacuum multi-chamber freeze-drying machine comprising an apparatus main body, at least one freeze-drying chamber, a water collection system, a temperature control system, and a pressure release system, wherein the apparatus main body has a positive pressure cabinet and a water refilling area, the positive pressure cabinet is installed above the water refilling area, the positive pressure cabinet has an operation space, the operation space has at least one operation surface, the freeze-drying chambers are installed within the positive pressure cabinet, and an opening and a chamber door corresponding to the opening are provided on the operation surface of each of the freeze-drying chambers, the water collection system includes a condensation chamber and a vacuum pump, the condensation chamber is installed within the apparatus main body, and the water collection system of the condensation chamber is provided within the apparatus main body. a water intake port and a sealed door corresponding to the water intake port are provided on the water supply area; the condensation chambers are respectively connected to the interiors of the freeze-drying chambers; the vacuum pump is connected to the condensation chambers; the temperature control system includes a compressor, a refrigerant conduit, a heater, a heat-conducting conduit and a heat exchanger, the compressor is connected to the condensation chambers via the refrigerant conduit, the heater is connected to the freeze-drying chambers via the heat-conducting conduit, the refrigerant conduit and the heat-conducting conduit pass through the heat exchanger respectively; the pressure release system has an intake pipe and an intake valve, the intake pipe is connected to each of the freeze-drying chambers and the outside of the device body, and the intake valve is installed on the intake pipe.

[0009] It is preferable that a heat-conducting flow path is uniformly provided in the freeze-drying chamber, the heat-conducting conduit is connected to the heat-conducting flow path, the heater is connected to a circulating pump via the heat-conducting conduit and is arranged along the inner wall of the condensing chamber so as to surround the condensing tube, the compressor is connected to the condensing tube via the refrigerant conduit, a control valve is provided in the heat exchanger, and the refrigerant conduit and the heat-conducting conduit each pass through the control valve in the heat exchanger.

[0010] It is preferable that the system further includes a heat dissipation device, the heat dissipation device including a heat collection cover, a heat exhaust pipe, and an exhaust fan, the heat collection cover covering the outside of the compressor or the vacuum pump, and the heat exhaust pipe having one end connected to the heat collection cover and the exhaust fan at the other end. Effect of the Invention

[0011] The multi-chamber vacuum freeze-drying machine of the present invention forms a heat-conducting channel inside the loading plate in each of the freeze-drying chambers, and combines it with a temperature control system to precisely control the temperature of the loading plate and quickly adjust the heating or cooling. This design can greatly shorten the temperature adjustment time during the freezing and drying processes in the multiple freeze-drying chambers, improve the overall drying efficiency, and achieve fast and uniform temperature control, so as to ensure consistent drying effects for samples and improve quality stability. [Brief description of the drawings]

[0012] [Figure 1] 1 is a perspective view of a freeze dryer according to an embodiment of the present invention; FIG. [Diagram 2] FIG. 2 is a front view showing the operation surface of a freeze dryer according to an embodiment of the present invention. [Figure 3A] 1 is a cross-sectional view of a freeze-drying chamber of a freeze-drying machine according to an embodiment of the present invention; FIG. [Figure 3B] FIG. 2 is a cross-sectional view showing the operation of "ampule crimping" in the freeze-drying chamber of the freeze-drying machine according to one embodiment of the present invention; [Figure 4] FIG. 2 is a cross-sectional view of a condensation chamber of a freeze dryer according to an embodiment of the present invention. [Diagram 5] FIG. 2 is a block diagram showing the layout of a water collection system and a temperature control system of a freeze dryer according to an embodiment of the present invention. [Figure 6A] FIG. 2 is a block diagram showing the operation of a freeze-drying machine according to an embodiment of the present invention for performing "pre-cooling"; [Figure 6B] FIG. 2 is a block diagram showing the operation of a freeze-drying machine according to an embodiment of the present invention for performing "condensation." [Figure 6C]FIG. 2 is a block diagram showing the operation of a freeze dryer according to an embodiment of the present invention performing "pressure release." [Figure 6D] FIG. 2 is a block diagram showing the operation of the freeze dryer according to an embodiment of the present invention for performing "temperature increase"; [Figure 7] 1 is a perspective view of a heat dissipation device of a freeze dryer according to an embodiment of the present invention; FIG. [Figure 8] FIG. 2 is a cross-sectional view showing a temperature measuring device in each freeze-drying chamber of the freeze-drying machine according to an embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] Other technical contents, features and effects of the present invention will be made clear in the following detailed description of the preferred embodiment with reference to the drawings. In order to make the drawings concise and clear, some conventional structures and components are depicted in a simplified manner or omitted without affecting the interpretation of the technical features of the invention. In addition, the dimensions of each structure and component in the drawings are not shown to actual size, but are shown in a ratio that is easy for the reader to see.

[0014] Unless otherwise defined, all technical and scientific terms used herein have their ordinary meanings as understood by one of ordinary skill in the art.

[0015] As used herein, unless a specific specific number is indicated, the articles "a," "one," or "any" refer to one or more than one (i.e., at least one). For example, "an element" refers to one element or more than one element.

[0016] The terms "upper", "lower", "front", "rear", "left", "right", "side", "top" and "bottom" used in the names of components or to describe their positional relationships are useful for understanding the positional relationships between each characteristic structure, but the actual orientation of the characteristic structure may vary depending on the angle at which it is placed or the corresponding relationship with the user's position, and are not intended to limit the scope of the present invention.

[0017] Please refer to Figures 1 and 2. FIG 1 is a perspective view of a freeze-drying device 10 according to an embodiment of the present invention. FIG 2 is a front view of an operation surface 215 of the freeze-drying device 10 according to an embodiment of the present invention. As shown in FIG 1 and FIG 2, the freeze-drying device 10 according to an embodiment of the present invention includes a device body 20, a plurality of freeze-drying chambers 30, a water collecting system 40, a temperature control system 50, and a pressure relief system 60.

[0018] The device body 20 has a positive pressure cabinet 21, a water refilling area 22, a first control interface 23 and a second control interface 24. The positive pressure cabinet 21 is installed above the water refilling area 22. The positive pressure cabinet 21 has an operation space 211. The operation space 211 is a positive pressure space, and is recessed inward from the front side of the positive pressure cabinet 21. More specifically, the front side of the positive pressure cabinet 21 has an opening 212. The operation space 211 is a space recessed backward from the opening 212 toward the positive pressure cabinet 21. The opening 212 has an isolation door 213, which is a pull-down door panel installed above the opening 212. The above-mentioned operation space 211 has a platform 214 and an operation surface 215. The platform 214 is located below the operation space 211. The platform 214 is used to place the material to be lyophilized (hereinafter referred to as sample) and to accommodate the sample ampoule and related tools, so that the operator can conveniently perform pre-treatment operations on the sample. The operation surface 215 is located at the rear of the operation space 211 and adjacent to the platform 214. The rehydration area 22 is a part of the device body 20 located below the positive pressure cabinet 21. The first control interface 23 is installed on the operation surface 215 and is used for manual control of the main operations of the freeze-drying machine 10. The first control interface 23 of this embodiment includes a vacuum valve 231, a pressure release valve 232, and a vacuum cover switch 233. The vacuum valve 231 controls the vacuum level inside the freeze-drying chamber 30 to effectively dehydrate and dry the sample. The pressure release valve 232 is used to release the pressure inside the freeze-drying chamber 30 and easily adjust the operation or process. The vacuum cover switch 233 allows the samples to be kept in a vacuum state by covering after freeze-drying is completed, for convenient storage. The second control interface 24 is installed at the front of the positive pressure cabinet 21, and provides a digitalized and visualized operation interface, facilitating accurate parameter setting and status monitoring. The second control interface 24 in this embodiment is a touch panel, which can set and control the temperature and parameters related to the capping operation.

[0019] The freeze-drying chamber 30 accommodates the sample and the ampoule, and provides a space for performing the freeze-drying operation. The freeze-drying chambers 30 of this embodiment are six in number and can be fitted into the positive pressure cabinet 21 from the operation surface 215. In detail, the freeze-drying chambers 30 are installed in the positive pressure cabinet 21, and an opening 301 and a chamber door 302 corresponding to the opening 301 are provided on the operation surface 215 of each freeze-drying chamber 30. Each freeze-drying chamber 30 has a corresponding first control interface 23. Each first control interface 23 can control various functions of the corresponding freeze-drying chamber 30. In other embodiments, the number of freeze-drying chambers 30 may be one or more, and the present invention is within the scope of the present invention as long as the function of the entire device can perform the freeze-drying operation of the samples accommodated in each freeze-drying chamber 30.

[0020] Please refer to Figure 3A. FIG. 3A is a cross-sectional view of a freeze-drying chamber 30 of a freeze-drying machine 10 according to an embodiment of the present invention. As shown in FIG. 3A, the freeze-drying chamber 30 includes at least one mounting plate 31, a sealing member 32, and a lifting device 33. The mounting plate 31 is a flat plate and is used to mount a number of ampoules (each of which contains a sample). The ampoules are generally fitted with a plastic cover having a gap. The ampoules and plastic covers are conventional containers commonly found in the art, and the details of their structures are not directly related to the present invention and will not be described in detail here. The sealing member 32 corresponds to the top of the mounting plate 31 and is used to seal the ampoule. The lifting device 33 is installed at the bottom of the mounting plate 31 and is used to control the lifting or lowering of the mounting plate 31.

[0021] Please refer to Figure 3B. As shown in Fig. 3B, the mounting plate 31 is raised to a predetermined height, and the top of the ampoule on the mounting plate 31 is brought into contact with the sealing member 32 to seal the ampoule. The lifting device 33 in this embodiment may be a hydraulic lifting structure or any other hydraulic mechanical device having an equivalent effect. The lifting device 33 may be an airbag-type lifting structure (not shown) or an airbag installed at the bottom of the mounting plate 31, and the height and position of the mounting plate 31 are controlled by injecting (inflating) gas into the airbag or releasing (exhausting) gas.

[0022] In another embodiment, the lifting device 33 may be installed on the sealing member 32 (not shown) and used to control the raising or lowering of the sealing member 32. The sealing member 32 may be lowered to a predetermined height, and the sealing member 32 may abut against the top of the ampool on the mounting plate 31 to seal the ampool. In this embodiment, the lifting device 33 may be a hydraulic lifting structure or other hydraulic mechanical devices having the same effect.

[0023] Please refer to Figures 4 and 5. FIG. 4 is a cross-sectional view of the condensation chamber 41 of the freeze-drying machine 10 according to an embodiment of the present invention. FIG. 5 is a block diagram showing the arrangement of the water collection system 40 and the temperature control system 50 of the freeze-drying machine 10 according to an embodiment of the present invention. As shown in FIG. 4 and FIG. 5, the water collection system 40 of the vacuum multi-chamber freeze-drying machine according to an embodiment of the present invention includes a condensation chamber 41 and a vacuum pump 42. The condensation chamber 41 is fitted into the device body 20 from above the water refilling area 22. In detail, the condensation chamber 41 is installed in the device body 20, and a water intake 411 and a sealing door 412 corresponding to the water intake 411 are provided above the water refilling area 22 of the condensation chamber 41. The condensation chamber 41 is installed at an angle, and the water intake 411 is provided at a low position. The condensation chamber 41 is connected to the inside of each freeze-drying chamber 30, and the water vapor in each freeze-drying chamber 30 flows to the condensation chamber 41. The condensation chamber 41 and each freeze-drying chamber 30 are independent spaces, and the degree of vacuum, temperature, and pressure can be controlled independently. A vacuum pump 42 is connected to the condensation chamber 41 and is used to evacuate the inside of the condensation chamber 41 and each freeze-drying chamber 30.

[0024] The temperature control system 50 is separated into a condensation section 501 and a heating section 502 .

[0025] The condensation section 501 is mainly used to lower the temperature of the freeze-dryer 10, and includes a compressor 51, a refrigerant conduit 52, and a condensation tube 53. The above-mentioned compressor 51 is connected to the condensation tube 53 via the refrigerant conduit 52. The refrigerant conduit 52 is used to transport the refrigerant, and in combination with the output of the compressor 51, transports the low-temperature, high-pressure refrigerant to the condensation tube 53 via the refrigerant conduit 52. The above-mentioned condensation tube 53 is installed inside the condensation chamber 41 and arranged along the inner wall of the condensation chamber 41 so as to surround it. In this embodiment, the condensation chamber 41 is formed in a cylindrical shape, and the condensation tubes 53 are arranged in a circular shape and arranged along the inner wall of the condensation chamber 41 so as to surround it. Therefore, when the refrigerant is transported to the condensation tube 53, the condensation chamber 41 can be lowered in temperature and condensed by the cooling action of the refrigerant.

[0026] In other embodiments, the number of compressors 51 may be two or more to enhance the cooling effect, or a two-stage compressor may be used, and a lower temperature may be obtained in the condensation operation based on the required performance, but the present invention is not limited to these embodiments. In addition, a cooling chamber 54 is installed on the path through which the refrigerant conduit 52 passes. The cooling chamber 54 contains a cooling fluid. The cooling fluid may be water, a coolant, or other substances having the same effect, but is not limited to these. The cooling fluid circulates through the pipes and enters the cooling chamber 54 through the refrigerant conduit 52, and absorbs heat when it comes into contact with the refrigerant conduit 52, so that the condensation section 501 in the temperature control system 50 can be maintained at a stable low temperature.

[0027] The heating unit 502 is mainly used to heat the freeze dryer 10, and includes a circulation pump 55, a heat conducting pipe 56, and a heater 57. The above-mentioned circulation pump 55 is connected to the heater 57 through the heat conducting pipe 56. The heat conducting pipe 56 is used to transport a heat conducting medium, which may be silicone oil, water, ethylene glycol solution, mineral oil, heat conducting liquid, fluorocarbon liquid, or other substances having the same effect, but is not limited thereto. The heat conducting pipe 56 communicates with the inside of each mounting plate 31. In the inside of each mounting plate 31 of this embodiment, heat conducting channels 311 are evenly distributed, and the heat conducting pipe 56 is connected to each heat conducting channel 311 inside each mounting plate 31 in a parallel connection manner. In combination with the driving of the circulation pump 55, the heat conducting medium is circulated and flowed uniformly inside the heat conducting pipe 56 and each mounting plate 31. Therefore, when the heat-conducting conduit 56 passes through the heater 57, the heater 57 heats the heat-conducting medium therein, and the heated heat-conducting medium then flows through each heat-conducting flow path 311, raising the temperature of each mounting plate 31 and achieving the desired heating effect.

[0028] The condensation section 501 and the heating section 502 are connected through a heat exchanger 58. In detail, a control valve 581 is installed in the heat exchanger 58, and the refrigerant conduit 52 and the heat conducting conduit 56 pass through the control valve 581. When the control valve 581 is opened, the heater 57 is turned off, and the refrigerant in the refrigerant conduit 52 exchanges heat with the heat conducting medium in the heat exchanger 58 and the heat conducting conduit 56, thereby lowering the temperature of the heat conducting medium. Therefore, when the lowered temperature heat conducting medium is transported to each heat conducting channel 311, the temperature of each mounting plate 31 is lowered, thereby achieving the purpose of condensation. On the contrary, when the control valve 581 is closed, the heat exchange between the condensation section 501 and the heating section 502 is interrupted, and at that time the heater 57 is started to heat the heat conducting medium, which circulates in the heat conducting channel 311 of each mounting plate 31, and each mounting plate 31 gradually increases in temperature, thereby achieving the desired heating effect.

[0029] The pressure release system 60 includes an intake pipe 61, an intake valve 62, and a filter 63. The intake pipe 61 communicates with each freeze-drying chamber 30. The intake valve 62 is installed in the intake pipe 61 and controls a switch that connects the intake pipe 61 to each freeze-drying chamber 30 and the outside of the device body 20. The filter 63 is installed at the front end of the intake pipe 61. The filter 63 is exposed to the outside of the device body 20 (see FIG. 1). The filter 63 has micropores that filter bacteria, and filters the gas that enters each freeze-drying chamber 30 from the filter 63 to achieve a sterilization effect.

[0030] In the following embodiment, a method for obtaining growth factors in blood using the freeze-drying technology of the freeze-drying device 10 of the present invention will be described to make the present invention more fully understood. (1) "Pre-treatment operation": As shown in Fig. 3A, a blood derivative (e.g., plasma) is injected into an ampoule, and multiple ampoules are placed on the placement plate 31. The placement plate 31 on which the ampoules are placed is then placed in the freeze-drying chamber 30, and the chamber door 302 is closed to seal the freeze-drying chamber 30. Since the operation space 211 is a positive pressure space, the risk of contamination due to the lid opening operation before the pre-treatment operation can be reduced. (2) "Pre-cooling": see FIG. 6A. FIG. 6A is a block diagram showing the operation of the freeze dryer 10 according to an embodiment of the present invention to perform "pre-cooling". As shown in FIG. 6A, when the control valve 581 of the heat exchanger 58 is opened, the compressor 51 is turned on, and the heater 57 is turned off, the refrigerant in the refrigerant conduit 52 exchanges heat with the heat transfer medium in the heat transfer conduit 56 in the heat exchanger 58, and the temperature of the heat transfer medium is lowered. When the lowered temperature heat transfer medium is transported to each heat transfer channel 311, the temperature of each mounting plate 31 is lowered, and the blood derivative in the ampoule is quickly frozen, and the liquid component in the blood derivative is changed to a solid (ice). At the same time, the refrigerant is also transported to the condensation tube 53 through the refrigerant conduit 52, and the condensation chamber 41 is also lowered in temperature. (3) "Condensation": See FIG. 6B. FIG. 6B is an operational block diagram of the freeze-drying device 10 according to an embodiment of the present invention performing "condensation". As shown in FIG. 6B, the vacuum pump 42 is turned on to form a vacuum environment. The pressure in each freeze-drying chamber 30 and the condensation chamber 41 is reduced to an ultra-low temperature through the vacuum pump 42, and the solid (ice) is directly sublimated into gas (vapor) under low temperature. The temperature of the condensation chamber 41 is set lower than that of each freeze-drying chamber 30 (usually at least lower than 20°C), so that after the blood derivative is sublimated from solid to vapor and released, the vapor is sucked in by the ultra-low temperature of the condensation chamber 41 and rapidly condensed in the condensation chamber 41 to form solid ice, which adheres to the surface of the condensation tube 53. In this process, the moisture in the blood derivative is captured, and the growth factors are retained in the ampoule. (4) "Crimping of ampool": See Fig. 3B. As shown in Fig. 3B, the lifting device 33 is started, the mounting plate 31 is controlled to rise, the top of the ampool is pushed to the position of the sealing member 32, and the sealing member 32 is crimped onto the top of the ampool, thereby sealing the ampool. (5) "Pressure Release": See Fig. 6C. Fig. 6C is an operational block diagram of the freeze-drying device 10 according to an embodiment of the present invention performing "pressure release". As shown in Fig. 6C, the vacuum pump 42 is turned off, the intake valve 62 is activated, and the gas outside the device body 20 is allowed to enter each freeze-drying chamber 30 through the filter 63 and the intake pipe 61, thereby restoring the pressure in the chamber to a normal state. (6) "Temperature Increase": see Fig. 6D. Fig. 6D is an operational block diagram of the freeze dryer 10 according to an embodiment of the present invention performing "temperature increase". As shown in Fig. 6D, the control valve 581 of the heat exchanger 58 is turned off, the compressor 51 is turned off, and the heater 57 is turned on. When the heat-conducting conduit 56 passes through the heater 57, the heater 57 heats the heat-conducting medium therein. When the heated heat-conducting medium flows through each heat-conducting flow path 311, the temperature of each support plate 31 increases. (7) "Removal operation": The operation process is completed by removing the mounting plate 31 and the ampoule from the freeze-drying chamber 30. Before the next freeze-drying operation, the sealed door 412 is opened so that the condensed water in the condensation chamber 41 can be removed.

[0031] When the freeze dryer 10 is operated, heat energy is easily generated by the compressor 51 and the vacuum pump 42. Therefore, if the heat cannot be effectively dissipated, there is a risk that the compressor 51 or the vacuum pump 42 will overheat and performance will deteriorate. This will cause the freeze drying performance to deteriorate, and in the worst case, the compressor 51 or the vacuum pump 42 may break down. In view of this problem, the freeze dryer 10 according to the present invention has a heat dissipation device 70. Please refer to FIG. 7. FIG. 7 is a perspective view showing the heat dissipation device 70 of the freeze dryer 10 according to one embodiment of the present invention. As shown in FIG. 7, the heat dissipation device 70 of this embodiment includes a heat collecting cover 71, a heat exhaust pipe 72, and an exhaust fan 73. The heat collecting cover 71 covers the outside of the compressor 51 or the vacuum pump 42 (only the compressor 51 is shown in FIG. 7) and collects the heat energy generated by it. The heat exhaust pipe 72 is connected to the heat collecting cover 71 at one end and is provided with an exhaust fan 73 at the other end. When the exhaust fan 73 is started, an airflow is generated in the heat exhaust pipe 72, and the heat inside the heat collection cover 71 can be exhausted. When the heat energy generated by the compressor 51 or the vacuum pump 42 is concentrated by the heat collection cover 71 and the exhaust fan 73 releases the heat, the operation of the device can be stabilized and the effectiveness of the freeze dryer 10 can be improved.

[0032] In addition, a temperature measuring device 34 is provided in each freeze-drying chamber 30 of the vacuum multi-chamber freeze-drying device according to the present invention. Please refer to FIG. 8. FIG. 8 is a cross-sectional view of the temperature measuring device 34 of each freeze-drying chamber 30 of the freeze-drying device 10 according to the present invention. As shown in FIG. 8, the temperature measuring device 34 adopts a probe structure that is inserted deep into the ampoule to accurately detect the temperature of the eutectic point of the freeze-dried material (e.g., a blood-derived sample), and the probe of the temperature measuring device 34 is inserted deep into the ampoule to directly measure the temperature of the sample, allowing the operator to grasp the state of the eutectic point of the sample in real time, so that the temperature control in the "pre-cooling" process can be performed more accurately. When the eutectic point is reached, the freeze-drying device 10 can quickly adjust the cooling speed, so that the sample can be in an appropriate frozen state, the "pre-cooling" process can be accelerated, and over-cooling can be prevented. This not only improves the overall work efficiency, but also ensures the stability and quality of the sample during the freeze-drying process.

[0033] The vacuum multi-chamber freeze dryer of the present invention has the following advantages (1) to (5) compared with the conventional technology. (1) The condensation chamber 41 in the water collection system 40 is designed to be inclined, and the water intake 411 is located at a low position, so that the condensate naturally collects at the lowest point and all of the condensate can be quickly removed. This design not only shortens the cleaning time, but also improves the convenience of operation and condensation efficiency. (2) A heat conducting channel 311 is provided inside the mounting plate 31 in the freeze-drying chamber 30, and is combined with a temperature control system 50 to precisely control the temperature of the mounting plate 31 and quickly adjust the heating or cooling. This design significantly shortens the temperature adjustment time during the freezing and drying process, improving the overall drying efficiency. Rapid and uniform temperature control ensures consistent drying effects for samples and increases the stability of quality. (3) Each freeze-drying chamber 30 is independently driven and controlled, and its multiple chamber split-flow design can prevent cross-contamination between different samples. In particular, samples of different origins are placed in different freeze-drying chambers 30, respectively, to ensure the independence of each sample. It can also reduce air contact between different samples, thereby effectively reducing the risk of cross-contamination. Furthermore, the split-flow installation of different samples allows operators to intuitively identify and operate them, reducing the risk of samples being mixed or placed incorrectly. (4) The temperature measuring device 34 can directly monitor the temperature of the eutectic point of the sample. Based on this, the drying process can be performed at the temperature of the closest eutectic point with a precise setting of pre-cooling time of the measured eutectic point, so as to prevent the problem of moisture not completely sublimating and to improve the drying efficiency. In addition, the high precision of the freeze-drying process makes it especially suitable for drying drugs or biological products with higher demands. (5) A microporous filter 63 is installed at the front end of the intake pipe 61 of the pressure relief system 60, which can effectively filter out bacterial particles in the intake air and ensure a sterile environment for the sample. This design is particularly suitable for fields with high requirements for sterility, such as pharmaceuticals and medical research, and can greatly reduce the risk of the sample being contaminated by the external environment, and improve the quality and safety of the product.

[0034] The preferred embodiments of the present invention have been disclosed above so that those skilled in the art can understand, but they are not intended to limit the present invention. Various changes and modifications can be made within the scope of the present invention. Therefore, the scope of the utility model registration claims of the present invention should be broadly interpreted to include such changes and modifications. [Explanation of symbols]

[0035] 10 Freeze dryer 20. Device body 21 Positive pressure cabinet 22 Water Refill Area 23 First control interface 24 Second Control Interface 30 Freeze-drying chamber 31 Loading plate 32 Sealing material 33 Lifting device 34 Temperature measuring device 40 Water Collection System 41 Condensation chamber 42 Vacuum Pump 50 Temperature Control System 51 Compressor 52 Refrigerant piping 53 Condenser tube 54 Cooling room 55 Circulation Pump 56 Heat conduction pipe 57 Heater 58 Heat exchanger 60 Pressure Relief System 61 Intake pipe 62 Intake valve 63 Filter 70 Heat dissipation device 71 Heat collector cover 72 Heat exhaust pipe 73 Exhaust fan 211 Operation space 212 Open mouth 213 Isolation Door 214 Platform 215 Operation surface 231 Vacuum valve 232 Pressure relief valve 233 Vacuum cover switch 301 Aperture 302 Chamber Door 311 Heat conduction channel 411 Water Intake 412 Sealed Door 501 Condenser 502 Heating section 581 Control valve

Claims

1. A vacuum multi-chamber freeze-drying machine comprising an apparatus body, at least one freeze-drying chamber, a water collection system, a temperature control system, and a pressure release system, The device body has a positive pressure cabinet and a water replenishment area, the positive pressure cabinet is installed above the water replenishment area, the positive pressure cabinet has an operation space, and the operation space has at least one operation surface; The freeze-drying chambers are installed in the positive pressure cabinet, and an opening and a chamber door corresponding to the opening are provided on an operation surface of each of the freeze-drying chambers; The water collection system includes a condensation chamber and a vacuum pump, the condensation chamber is installed in the apparatus body, a water intake port and a sealed door corresponding to the water intake port are provided on the water refilling area of ​​the condensation chamber, the condensation chamber communicates with the interior of each of the freeze-drying chambers, and the vacuum pump is connected to the condensation chamber; the temperature control system includes a compressor, a refrigerant conduit, a heater, a hot conduit and a heat exchanger, the compressor is connected to the condensation chamber through the refrigerant conduit, the heater is connected to the freeze-drying chamber through the hot conduit, the refrigerant conduit and the hot conduit pass through the heat exchanger, respectively; 13. A vacuum multi-chamber freeze-drying machine, comprising: a pressure release system having an intake pipe and an intake valve, the intake pipe communicating with each of the freeze-drying chambers and the outside of the device body, and the intake valve installed in the intake pipe.

2. A heat conducting flow path is uniformly provided in the freeze-drying chamber, The heat conducting conduit is connected to the heat conducting flow path, The heater is connected to a circulation pump via the heat-conducting pipe; a condensation tube is disposed along an inner wall of the condensation chamber, the compressor being connected to the condensation tube via the refrigerant conduit; A control valve is provided in the heat exchanger, 2. The vacuum multi-chamber freeze-drying machine according to claim 1, wherein the refrigerant conduit and the heat conduit each pass through the control valve within the heat exchanger.

3. Further comprising a heat dissipation device; The heat dissipation device includes a heat collection cover, a heat exhaust pipe, and an exhaust fan, The heat collecting cover covers the outside of the compressor or the vacuum pump, 2. The vacuum multi-chamber freeze dryer according to claim 1, wherein the heat exhaust pipe has one end connected to the heat collection cover and the other end provided with the exhaust fan.

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