Topical skin composition

Abstract

To provide an external composition for skin that improves resilience and firmness of the skin, wherein the composition has an improved use feeling with reduced stickiness felt when a large amount of nicotinamide is blended, deposition of the composition is reduced during its use or storage, and the composition has improved emulsion stability at high temperatures.SOLUTION: An external preparation for skin contains following components (A)-(D): (A) nicotinamide 1-10 mass%, (B) halotolerant water-soluble polymer 0.05-2 mass%, (C) a phosphate surfactant and (D) a polyhydric alcohol 5-25 mass%.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for external use on the skin which improves the firmness and elasticity of the skin, has a non-sticky feel when used, has an excellent effect of inhibiting crystal precipitation, and has good emulsion stability at high temperatures. [Background technology]

[0002] In recent years, many cosmetic products have been launched with the aim of improving age spots, wrinkles, sagging skin, pigmentation, etc., caused by aging, stress, ultraviolet rays, dry air, etc. In particular, many people wish to improve morphological changes such as wrinkles and sagging skin, which give the impression of advanced aging. The inclusion of nicotinamide as an active ingredient has the effect of improving rough skin and keratin, is highly safe even when incorporated in large amounts, and can improve the firmness and elasticity of the skin (Patent Document 1).

[0003] However, it is known that the incorporation of a large amount of nicotinamide causes stickiness and squeaking, resulting in an unsatisfactory feel when used (Patent Document 2). In particular, in the case of a topical skin composition containing 1% by mass or more of nicotinamide, it is known that when the contents adhere to the opening or cap and then dry, or when the contents adhere to the side of the container, crystals of nicotinamide precipitate (Patent Document 3, Patent Document 4).

[0004] In contrast, in Patent Document 2, the stickiness caused by the incorporation of a large amount of nicotinamide was suppressed by the combined use of a specific branched chain hydrocarbon and a specific highly spreadable oil, but the contents adhered to the mouth or cap, causing crystals to precipitate, which could prevent smooth opening and closing of the container. In addition, it has been reported that an oil-in-water emulsion composition was obtained that had no irritation or stickiness even when 1% or more of nicotinamide was incorporated, was excellent in feel when used, and had excellent crystallization suppression effect, by using an ester of linear fatty acid and polyethylene glycol as an emulsifier and incorporating petrolatum (Patent Document 5). However, although Patent Document 5 obtained a good skin topical composition overall, it was limited to an oil-in-water emulsion that required petrolatum, and it is difficult to say that it has sufficient versatility. In Patent Document 3, the incorporation of a specific cation-containing polymer improved crystallization, but the stickiness increased and the feel when used was poor.

[0005] On the other hand, water-soluble polymers that are used as thickeners for skin external preparations include acrylic acid thickeners such as carbomer, but they generally have poor salt tolerance and, depending on the type of electrolyte, can cause significant viscosity reduction and aggregation, which is well known to cause poor stability, and various approaches have been developed to develop these technologies. For example, Patent Document 6 discloses a technology that uses a specific surfactant (polyoxyethylene-added castor oil and polyoxyethylene-added sorbitol fatty acid ester) to obtain stability at high temperatures. Furthermore, as the room temperature in summer increases due to global warming, a formulation with improved high temperature resistance is required more than ever before. Specifically, until now, stability at 50°C or higher was thought to be sufficient, but recently it may be necessary to check storage stability up to about 60°C. Generally, increasing the storage temperature leads to a decrease in viscosity and a significant decrease in stability. In other words, storage at higher temperatures places a greater burden on storage stability than storage at low temperatures.

[0006] For these reasons, by combining nicotinamide with a phosphate ester surfactant or its derivative, it is possible to improve the firmness and elasticity of the skin; however, no topical skin composition is known that is non-sticky, has an excellent feel when used, does not precipitate crystals, and has good emulsion stability even at high temperatures. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Japanese Patent Application Publication No. 10-130135 [Patent Document 2] Special Publication No. 2003-502435 [Patent Document 3] Special Publication No. 2002-537241 [Patent Document 4] JP 2018-168105 A [Patent Document 5] JP 2018-172304 A [Patent Document 6] JP 2018-168146 A DISCLOSURE OF THEINVENTION [Problem to be solved by the invention]

[0008] The present invention aims to improve the stickiness and other sensations that occur when a high content of nicotinamide is used, as well as the precipitation that occurs during use and storage, and to further improve the emulsion stability at sufficiently high temperatures. [Means for solving the problem]

[0009] In view of the above circumstances, the present inventors have conducted extensive research to solve the above problems, and have found that The following components: (A) to (D); (A) Nicotinamide 1 to 10% by mass (B) Salt-resistant water-soluble polymer 0.05~2% by mass (C) Phosphate ester surfactants (D) Polyhydric alcohol 5 to 25% by mass It has been found that an external skin preparation comprising the above-mentioned compound can solve the above problems, and thus the present invention has been completed.

[0010] The present invention further relates to a composition in which the blending mass ratio of component (D) to component (A) is The present invention relates to a composition for external use on the skin, in which (D) / (A) is ≧2.

[0011] The present invention further relates to a salt-tolerant water-soluble polymer of component (B). One or more selected from cellulose derivatives, hydrophobically modified polyether urethanes, and copolymers containing acryloyldimethyltaurate salts as monomers The present invention relates to a composition for external use on the skin,

[0012] The present invention further relates to a composition for external use on the skin, wherein the salt-resistant water-soluble polymer of component (B) is one or more selected from the group consisting of hydroxypropyl methylcellulose stearoxy ether, (sodium acrylate / sodium acryloyldimethyltaurate) copolymer, (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer, (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer, and (PEG-240 / decyltetradeceth-20 / HDI) copolymer.

[0013] The present invention further relates to a sheet-type external preparation for skin impregnated with the above-mentioned composition for external use on skin. Effect of the Invention

[0014] The composition for external use on the skin of the present invention improves the firmness and elasticity of the skin, is non-sticky and has an excellent feel when used, and also has excellent effects of inhibiting crystal precipitation and emulsion stability at high temperatures. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] The present invention will be described in detail below. In this specification, the symbol "to" means a range including the numerical values ​​before and after it. Furthermore, numerical values ​​expressed as % are values ​​based on mass unless otherwise specified.

[0016] Component (A): Nicotinamide Nicotinamide (C6H6NO / molecular weight: 122.12), component (A) in the present invention, is a water-soluble amide compound of nicotinic acid (vitamin B3, niacin). In the present invention, it is possible to blend one extracted from rice bran or one synthesized. Specifically, it is possible to use one listed in the 15th revised Japanese Pharmacopoeia of 2008. It is easily soluble in water and ethanol, but is poorly soluble in diethyl ether. It is also known to be poorly soluble in polyhydric alcohols and oils.

[0017] The amount of component (A) is 1 to 10% by mass (hereinafter simply abbreviated as "%"). More preferably, it is 3 to 8%. When the amount of component (A) is within this range, it is effective in treating rough skin and improving skin firmness and elasticity. However, even if it is incorporated at more than 10%, the effect tends to plateau, and there is also a risk of crystallization when the water in the composition evaporates.

[0018] Component (B): Salt-resistant water-soluble polymer The salt-resistant water-soluble polymer (B) in the present invention is a water-soluble polymer that exhibits sufficient viscosity even when electrolytes such as salts and metal oxides are dissolved in water.Specific structures that can be suitably used include cellulose derivatives, cellulose derivatives, hydrophobically modified polyether urethanes, copolymers containing acryloyldimethyltaurine salts as monomers, and copolymers containing acryloyldimethyltaurine salts as monomers, and the like, and can be contained alone or in appropriate combination of two or more kinds.

[0019] Examples of cellulose derivatives include cellulose-based polymers such as methyl cellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, hydroxypropyl methylcellulose stearoxy ether, sodium carboxymethyl cellulose (CMC), crystalline cellulose, and cellulose powder.

[0020] The hydrophobically modified polyether urethane used in the present invention is a polymer having a urethane bond modified with a hydrophobic group, and is preferably represented by the following chemical formula (I). R 1 -{(OR 2 ) k -OCONH-R 3 [-NHCOO-(R 4 -O) n -R 5 ] h} m (I) (R in the formula 1 represents a hydrocarbon group, R 2 and R 4 each independently represents an alkylene group having 2 to 4 carbon atoms; R 3 represents a hydrocarbon group that may have a urethane bond, which may be linear, branched, or contains an aliphatic ring or an aromatic ring; R 5 represents a branched chain hydrocarbon group; m is an integer of 2 or more, h is an integer of 1 or more, and k and n are each independently an integer in the range of 0 to 1000, where k+n≧1.

[0021] A preferred example of the hydrophobically modified polyether urethane is (PEG-240 / decyltetradeceth-20 / HDI) copolymer.

[0022] Examples of copolymers containing acryloyldimethyltaurate salts as monomers include (sodium acrylate / sodium acryloyldimethyltaurate) copolymers, (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymers, and (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymers.

[0023] Suitable commercially available salt-resistant water-soluble polymers include Sangelose (manufactured by Daido Kasei Co., Ltd.) as a hydroxypropyl methylcellulose stearoxy ether, ADEKA NOL GT-700 (manufactured by Adeka Corporation) as a (PEG-240 / decyltetradeceth-20 / HDI) copolymer, SIMULGEL EG (manufactured by Seppic Corporation) as a (sodium acrylate / sodium acryloyldimethyl taurate) copolymer, SEPINOV EMT10 (manufactured by Seppic Corporation) as a (hydroxyethyl acrylate / sodium acryloyldimethyl taurate) copolymer, and ARISTOFLEX AVC (manufactured by Clariant) as an (ammonium acryloyldimethyl taurate / vinyl pyrrolidone) copolymer.

[0024] The blending amount of component (B) is preferably 0.05 to 2%, and more preferably 0.1 to 1.0%, because this range provides excellent effects of reducing stickiness and suppressing crystal precipitation.

[0025] Component (C): The phosphate surfactant is not particularly limited, but examples thereof include higher alcohol phosphate esters and / or salts thereof, and higher alcohol ethylene oxide adduct phosphate esters and salts thereof.

[0026] A higher alcohol phosphate is a compound in which the hydrogen atom of one or more of the three hydroxyl groups of phosphoric acid is substituted with a higher alcohol residue. The higher alcohol phosphate may be a monoester, diester, or triester, and among these, a monoester is preferred.

[0027] The number of carbon atoms in the monovalent higher alcohol residue constituting the ester moiety in the higher alcohol phosphate ester is preferably 8 to 30, more preferably 10 to 25, and even more preferably 12 to 20. Furthermore, it may be a saturated or unsaturated hydrocarbon. The higher alcohol residue may be linear or branched, but is preferably linear.

[0028] Examples of higher alcohol phosphate salts include inorganic salts, organic amine salts, and basic amino acid salts. Examples of inorganic salts include alkali metal salts such as sodium salts and potassium salts. Examples of organic amine salts include monoethanolamine salts, diethanolamine salts, and triethanolamine salts.

[0029] Specific examples of higher alcohol phosphate esters or higher alcohol phosphate ester salts include sodium lauryl phosphate, disodium lauryl phosphate, potassium lauryl phosphate, cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, etc. Commercially available products include cetyl phosphate under the trade name "Hostaphat CC100" (manufactured by Clariant), potassium cetyl phosphate under the trade name "Hostaphat CK100" (manufactured by Clariant), and "AMPHISOL K" (manufactured by DSM Nutrition).

[0030] The higher alcohol ethylene oxide adduct phosphate is an ether phosphate composed of an ethylene oxide residue and a monovalent higher alcohol residue. The average number of moles of oxyalkylene added to the ethylene oxide is, for example, 2 to 25, and preferably 2 to 20.

[0031] The number of carbon atoms in the monovalent higher alcohol residue constituting the higher alcohol ethylene oxide adduct phosphate ester is preferably 8 to 30, more preferably 10 to 25, and even more preferably 12 to 20, such as lauryl, cetyl, stearyl, and oleyl groups. Furthermore, the monovalent higher alcohol hydrocarbon group may be a saturated or unsaturated hydrocarbon. The monovalent higher alcohol hydrocarbon group may be linear or branched.

[0032] The higher alcohol ethylene oxide adduct phosphate ester may be any of a monoester, a diester, and a triester.

[0033] Examples of the higher alcohol ethylene oxide adduct phosphate ester salt include inorganic salts, organic amine salts, basic amino acid salts, etc. Examples of the inorganic salt include alkali metal salts such as sodium salts and potassium salts, etc. Examples of the organic amine salt include monoethanolamine salts, diethanolamine salts, triethanolamine salts, etc.

[0034] Specific examples of the higher alcohol ethylene oxide adduct phosphate ester or higher alcohol ethylene oxide adduct phosphate ester salt include ethylene oxide lauryl ether phosphates such as laureth-2 phosphate, laureth-4 phosphate, dilaureth-10 phosphate, and trilaureth-4 phosphate; ethylene oxide cetyl ether phosphates such as ceteth-10 phosphate and ceteth-20 phosphate; ethylene oxide stearyl ether phosphates such as steareth-2 phosphate and steareth-3 phosphate; ethylene oxide oleyl ether phosphates such as oleth-3 phosphate, oleth-4 phosphate, oleth-7 phosphate, oleth-8 phosphate, oleth-20 phosphate, and dioleth-8 phosphate; ethylene oxide alkyl (C12-15) ether phosphates such as (C12-15) pareth-3 phosphate, (C12-15) pareth-6 phosphate, di(C12-15) pareth-4 phosphate, di(C12-15) pareth-6 phosphate, and tri(C12-15) pareth-2 phosphate; and salts thereof. Among them, ethylene oxide lauryl ether phosphate, ethylene oxide alkyl (C12-15) ether phosphate, ethylene oxide cetearyl ether phosphate, ethylene oxide oleyl ether phosphate, and their salts are preferred, and more preferred are laureth-4 phosphate, trilaureth-4 phosphate, (C12-15) pareth-3 phosphate, triceteareth-4 phosphate, oleth-3 phosphate, oleth-7 phosphate, oleth-20 phosphate, dioleth-8 phosphate, tri(C12-15) pareth-2 phosphate, and their salts. Commercially available products of these include oleth-3 phosphate under the trade name "Hostaphat O300" (manufactured by Clariant), tri(C12-15) pareth-2 phosphate under the trade name "NIKKOL TDP-2" (manufactured by Nikko Chemicals), and the like.

[0035] The component (C) may be used alone or in combination of two or more kinds.

[0036] The amount of component (C) blended is not particularly limited, but is desirably 0.1 to 3%, more preferably 0.2 to 2%, and even more preferably 0.3 to 1%.

[0037] Component (D): Polyhydric alcohol The polyhydric alcohol (D) of the present invention is blended to dissolve the component (A) and suppress crystal precipitation. A polyhydric alcohol alone has almost no effect in suppressing crystal precipitation, but good results can be obtained by using it in combination with a salt-resistant water-soluble polymer. The component (D) is not particularly limited as long as it is one that is generally used in external compositions, but it may be, for example, an alkanediol such as 1,3-butylene glycol, which is a dihydric alcohol, glycerin or diglycerin, which is a trihydric or higher alcohol, or a sugar or sugar alcohol with many hydroxyl groups, and one or more kinds may be appropriately selected and used as necessary.

[0038] The amount of component (D) is preferably 25% or less, since a large amount of polyhydric alcohol tends to cause stickiness in use. On the other hand, in order to dissolve component (A) and suppress crystal precipitation, component (D) must be contained in an amount of 5% or more of the entire composition, and furthermore, it is more preferable to contain component (D) in an amount of at least twice that of component (A), in order to suppress crystal precipitation.

[0039] By blending the above-mentioned components (A) to (D), the topical skin composition of the present invention can be made to improve the firmness and elasticity of the skin and prevent and improve morphological changes due to aging such as wrinkles and sagging, while also being excellent in the feel of use without any irritation or stickiness, as well as having excellent crystal precipitation inhibitory effect and emulsion stability at high temperatures.

[0040] In addition to the above-mentioned components, the topical skin composition of the present invention may contain optional components that are typically blended into topical skin compositions within the scope of the invention, i.e., aqueous components, oils, powders, film-forming agents, surfactants, oil-soluble gelling agents, organically modified clay minerals, resins, colorants, ultraviolet absorbers, preservatives, antibacterial agents, fragrances, antioxidants, pH adjusters, chelating agents, cosmetic ingredients, and the like, other than the above-mentioned essential components, provided that the effects of the present invention are not impaired.

[0041] The composition for external use on the skin of the present invention can be made into various dosage forms by combining with other ingredients, specifically, it can be made into various dosage forms such as liquid, gel, paste, cream, solid, sheet, etc.

[0042] The skin external composition of the present invention is suitable for preparing cosmetics and quasi-drugs containing a high content of nicotinic acid amide, particularly for the purpose of anti-aging effects.Specifically, it can be used in, for example, lotions, milky lotions, creams, beauty essences, massage cosmetics, pack cosmetics, hand creams, body lotions, body creams, etc.Methods of use include using it on hands, fingers, or cotton, impregnating it into nonwoven fabric, or making it into an aerosol using a propellant. EXAMPLES

[0043] The present invention will be described in more detail below with reference to examples, but the present invention is not limited thereto. Unless otherwise specified, the blending amount of each component is expressed as mass % based on the system in which the component is blended.

[0044] Experiment 1: Effect of nicotinamide on thickening agents Using 1% carbomer gel, we confirmed the change in viscosity depending on the amount of nicotinamide blended. The results are shown in Table 1. (Experimental Method) 1: A 1% carbomer aqueous solution was adjusted to pH 6.5 using potassium hydroxide and gelled to give a 1% carbomer gel. 2: A predetermined amount of nicotinamide was added to the above 1% carbomer gel, and after uniform dissolution, it was left at 20°C for 4 hours and the viscosity was measured. The degree of viscosity reduction was calculated based on the formula 1. (Measurement conditions) Measuring equipment: Toki Sangyo VISCOTESTER TVB-10 Measurement conditions: Rotor M3, rotation speed 12 rpm, after 60 seconds at 20℃

[0045]

number

[0046] [Table 1]

[0047] (Consideration) In the low concentration range where the amount of nicotinamide blended did not reach 1%, there was little decrease in viscosity. Although nicotinamide is an electrolyte, it was suggested that it has a relatively small effect on the decrease in viscosity of electrolyte-sensitive water-soluble polymer gels such as carbomer, which is widely used as a thickening and stabilizing agent in cosmetics. However, this experiment showed that when the blended amount exceeded 1% and the concentration became high, a clear decrease in viscosity occurred. As a result, there was concern that stability problems such as separation would become more likely to occur. When a similar test was carried out using sodium chloride, the results were as follows. When 0.1% sodium chloride, a typical electrolyte, was added to 1% carbomer gel, the viscosity was 35.3 mPa.s (measurement conditions: rotor M1, rotation speed 60 rpm, after 60 seconds at 20°C). Viscosity reduction rate = 99.4%

[0048] Invention products 1 to 10 and comparative products 1 to 11: Oil-in-water emulsion cream An oil-in-water emulsion cream was prepared according to the formula shown in Table 2 below, and the skin firmness, elasticity, stickiness, and crystal precipitation inhibitory effects were evaluated using the methods described below. The results are also shown in Table 2.

[0049] (Evaluation items) Skin firmness and elasticity Non-sticky Crystal precipitation suppression effect Emulsion stability at high temperatures

[0050] (Evaluation method) [Sensory evaluation method for skin firmness, elasticity, and non-stickiness] The evaluation was carried out by 10 expert panelists, women in their 20s to 40s who had been trained in sensory evaluation. The expert panelists evaluated each sample on the stickiness immediately after application to the skin, and on the firmness and elasticity of the skin the following morning. The following absolute evaluation was performed on a 5-point scale, the average value was calculated, and the result was judged according to the following 4-point scale.

[0051] (Method of evaluating skin firmness and elasticity) (Score):(Rating) 5 points: Skin feels very firm and elastic 4 points: Skin feels firm and elastic 3 points: Normal (no change felt) 2 points: Somewhat dissatisfied with skin firmness and elasticity, not desirable 1 point: Skin lacks firmness and elasticity 4-level evaluation criteria (Judgment): (Average score) ◎: 4 points or more ○: 3 points or more but less than 4 points △: 2 points or more but less than 3 points ×: Less than 2 points

[0052] (Method of evaluating non-stickiness) (Score):(Rating) 5 points: No sticky feeling 4 points: Almost no stickiness 3 points: Feels slightly sticky 2 points: Sticky feeling 1 point: Very sticky feeling 4-level evaluation criteria (Judgment): (Average score) ◎: 4 points or more ○: 3 points or more but less than 4 points △: 2 points or more but less than 3 points ×: Less than 2 points

[0053] [Method for evaluating the effect of suppressing crystal precipitation] To evaluate the crystal precipitation suppression effect, 4 g of the sample was applied to the bottom of a sterile petri dish (made of polystyrene: 90 mmΦ x 15 mm) and left in an open state (without a lid) in a 30°C incubator for 24 hours. After that, each sample was observed under a microscope. The crystal precipitation state was observed under an optical microscope at 40x magnification using a polarizing filter. <Judgment criteria> (Judgment): (Evaluation) ◎: No crystal precipitation. ○: A slight amount of crystal precipitation is observed. ×: Crystal precipitation is clearly observed.

[0054] [Method for evaluating emulsion stability at high temperatures] (Evaluation of emulsion stability) Each of the samples of Examples 1 to 10 and Comparative Example 1 to 100 was stored at a temperature of 60° C. for two weeks, and the change in appearance was visually observed and rated according to the following three-level rating criteria. Three-level evaluation criteria (Judgment): (Evaluation result) ◎: No change, uniform: Very good ○: No change for 1 week, but separation is observed after 2 weeks: Good ×: Separation observed within one week: poor

[0055] [Table 2]

[0056] Cetyl phosphate potassium*1 AMPHISOL K DSM Nutrition Tri(C12-15)palladium-2 phosphate*2 NIKKOL TDP-2 Manufactured by Nikko Chemicals 37.5% (Sodium acrylate / Sodium acryloyldimethyltaurate) copolymer / isohexadecane / polysorbate 80 / water mixture*3 SIMULGEL EG: Seppic (PEG-240 / Decyltetradeceth-20 / HDI) Copolymer*4 ADEKA NOL GT-700: ADEKA Corporation Hydroxypropyl methylcellulose stearoxy ether*5 Sangelose 60L: Daido Kasei Co., Ltd.

[0057] Manufacturing method (a): Dissolve and mix 1 to 10 uniformly at 70°C. (b): Add the other ingredients to the purified water in order and dissolve and mix uniformly at 70°C. (c): Add (a) to (b) and emulsify at 70°C. (d): Stir and cool to 40°C to obtain the desired composition.

[0058] As is clear from the results in Table 2, the topical skin compositions of Examples 1 to 8 of the present invention showed better results in terms of skin firmness and elasticity, non-stickiness, crystallization inhibition effect, and stability over a two-week period at 60°C, compared to the topical skin compositions of Comparative Examples 1 to 7. In contrast, when the stability over time of comparative products 1 and 2, which do not contain (C) phosphoric acid surfactant, was tested, significant separation was observed after two days. (A) Comparative Example 3, which does not contain nicotinamide, was rated low in skin firmness and elasticity. (B) Comparative Example 4, which does not contain salt-resistant polymer, had poor stability over time, and separation was observed the next day, and crystal precipitation was also observed. (D) Comparative Example 5, which has 1 polyhydric alcohol / (A) nicotinamide, showed crystal precipitation. (B) Comparative Example 6, which uses carbomer, a general thickener, instead of the salt-resistant water-soluble polymer, was also in a good condition after production, but separation occurred when the stability over time was checked. Furthermore, crystal precipitation also occurred. (D) Comparative Example 7, which contains ethanol, a monohydric alcohol, instead of the polyhydric alcohol, showed a good feel with little stickiness, but crystal precipitation occurred.

[0059] Example 9: Oil-in-water sunscreen cream (Component) (mass%) 1.1,3-Butylene glycol 12.0 2. Diglycerin 3.0 3. Appropriate amount of purified water 4. Nicotinamide 6.0 5. Methyl parahydroxybenzoate 0.1 6. Sucrose stearate 1.0 7. (Hydroxyethyl acrylate / Sodium acryloyldimethyl taurate) copolymer*3 0.1 8. Xanthan gum 0.05 9.30% sodium dilauroyl glutamate lysine aqueous solution 0.3 10. Glyceryl monostearate 1.5 11. Sorbitan Sesquioleate 0.3 12. Hydrogenated lecithin 0.1 13. Phytosteryl / Octyldodecyl Lauroyl Glutamate 3.0 14. Cetyl phosphate diethanolamine *6 0.5 15. Ethylhexyl methoxycinnamate 5.0 16. Diethylamino hydroxybenzoyl hexyl benzoate 1.0 17. Jojoba oil 5.0 18. Shea Butter 2.0 19. Squalane 1.0 20. Ceramide 3 0.1 21. Tocopherol 0.05 22. Cetostearyl alcohol 2.0 23. Cholesterol 0.3 24. Ubiquinone 0.001 25. Hydrogenated polyisobutene 2.0 26.40% polyacrylamide solution 0.3 (Hydroxyethyl acrylate / Sodium acryloyldimethyl taurate) copolymer *3 SEPINOV EMT10: Manufactured by Seppic Cetyl phosphate diethanolamine*6 AMPHISOL (DSM Nutrition)

[0060] (Manufacturing method) (a): Components 1 to 9 are uniformly dissolved and mixed at 70°C. (b): Dissolve and mix ingredients 10 to 25 uniformly at 80°C. (c): Add (b) to (a) and emulsify at 70°C. (d): Add 26 to (c) and mix until uniform. (e): Cooled to 40°C to obtain an oil-in-water sunscreen cream.

[0061] The oil-in-water emulsion of Example 9 was a composition for external use on the skin that was excellent in skin firmness and elasticity, anti-stickiness, and crystal precipitation inhibitory effect, as well as stability over time.

[0062] Example 10: Oil-in-water emulsion serum (Component) (mass%) 1.1,3-Butylene glycol 5.0 2. Dipropylene glycol 5.0 3. Xylitol 3.0 4.Appropriate amount of purified water 5. Nicotinamide 4.0 6. (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.1 7.92% (Ammonium acryloyldimethyltaurate / VP) copolymer / (t-butanol / water mixture)*7 0.1 8. Polyoxyethylene sorbitan coconut oil fatty acid (20E.O.) 0.5 9. Phytosteryl Macadamiate 2.0 10. Light liquid isoparaffin 3.0 11. Dimethylpolysiloxane (5CS) 3.0 12. Oleth-3 phosphate 0.2 13. Polyglyceryl-5 Myristate 1.0 14. Tocopherol 0.1 15. Stearyl glycyrrhetinate 0.05 16.10% sodium hydroxide solution 0.5 17. Phenoxyethanol 0.2 18. Ethanol 5.0 19. 0.3% water-soluble collagen solution 0.1 20. 0.4% water-soluble elastin solution 0.1 21.1% sodium hyaluronate aqueous solution 0.1 22. Tremella polysaccharide 0.1 92% (Acryloyldimethyltaurate ammonium / VP) copolymer (t-butanol / water mixture) *7 ARISTOFLEX AVC: Clariant Oleth-3 phosphate*8 Hostaphat O300 Clariant

[0063] (Manufacturing method) (a): Dissolve and mix ingredients 1 to 8 uniformly at 70°C. (b): Dissolve and mix ingredients 9 to 15 uniformly at 80°C. (c): Add (b) to (a) and emulsify at 70°C. (d): After starting to cool (c), components 18 to 22 were added successively at 45°C, and then cooled to 40°C to obtain an oil-in-water emulsion serum.

[0064] The oil-in-water emulsion cosmetic serum of Example 10 was a composition for external use on the skin that was excellent in skin firmness and elasticity, anti-stickiness and crystal precipitation inhibitory effects, and stability over time.

[0065] Example 11: Water-based moisturizing gel (Component) (mass%) 1.1,2 Pentanediol 0.5 2.1,3 Butylene glycol 12.0 3. Methylgluceth-10 3.0 4.37.5% (Sodium acrylate / Sodium acryloyldimethyltaurate) copolymer / isohexadecane / polysorbate 80 / water mixture*3 0.3 5.5% Polyquaternium-51 aqueous solution 0.3 6. Sodium hyaluronate 0.01 7. (PEG-240 / Decyltetradeceth-20 / HDI) Copolymer *7 0.7 8. Nicotinamide 3.0 9. Dipotassium glycyrrhizinate 0.1 10. Carbomer 0.1 11. 10% potassium hydroxide solution 1.0 12. Potassium cetyl phosphate 0.2 13. PEG-100 hydrogenated castor oil 0.5 14. Ethylhexylglycerin 0.3 15・Purified water (appropriate amount) (PEG-240 / Decyltetradeceth-20 / HDI) copolymer *7 ADEKA NOL GT-700: Manufactured by ADEKA Corporation Potassium cetyl phosphate AMPHISOL K*1 DSM Nutrition

[0066] (Manufacturing method) (a): Components 12 to 14 are heated and dissolved in advance. (b) (a) and each of the ingredients 1 to 11 were added to ingredient 15, mixed, and stirred until transparent and uniform, to obtain an aqueous moisturizing gel.

[0067] The aqueous moisturizing gel of Example 11 was a composition for external use on the skin that was excellent in skin firmness and elasticity, anti-stickiness and crystal precipitation inhibitory effect, and stability over time.

[0068] Example 12: Sheet mask (non-woven fabric impregnated with serum) (Component) (mass%) 1.1,2-Hexanediol 0.5 2.1,3-Butylene glycol 10.0 3. Methylgluceth-10 1.0 4. (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.05 5.37.5% (Sodium acrylate / Sodium acryloyldimethyl taurate) copolymer / isohexadecane / polysorbate 80 / water mixture*3 0.1 6. Xanthan gum 0.2 7. PEG / PPG / Polybutylene Glycol-8 / 5 / 3 Glycerin 0.3 8. Sodium hyaluronate 0.01 9. Nicotinamide 7.0 10. Starch octenyl succinate Al 0.5 11. Dipotassium glycyrrhizinate 0.1 12. Glycerin 5.0 13. δ-tocopherol 0.05 14. Cetyl phosphate 0.1 15.PPG-6-decyltetradeceth-30 0.5 16. Ethylhexylglycerin 0.2 17. Methylparaben 0.1 18.Purified water (appropriate amount) 19·10% potassium hydroxide solution 0.2 Cetyl phosphate Hostaphat CC100*9 Clariant 37.5% (Sodium acrylate / Sodium acryloyldimethyltaurate) copolymer / isohexadecane / polysorbate 80 / water mixture*3 SIMULGEL EG: Seppic

[0069] (Manufacturing method) (a): Components 12 to 17 are heated and dissolved in advance. (b) (a) and each of the ingredients 1 to 11 were added to ingredient 18 and mixed and stirred until uniform to obtain a beauty essence. (c): 19 was added to (b) and mixed to prepare a sheet mask concentrate. (d) 30 g of this beauty essence was impregnated into a nonwoven fabric (500 cm2, basis weight 60 g / m2, rayon / polypropylene = 70% / 30%) formed into the shape of a face, and the resultant was packed into an aluminum sheet bag to prepare a sheet mask.

[0070] The sheet mask of Example 12 had excellent elasticity and firmness of the skin, was not sticky, and did not precipitate crystals during use, and had excellent stability over time.

[0071] Example 13: All-in-one gel (Component) (mass%) 1. Diisostearyl malate 1.0 2. Behenyl alcohol 1.0 3. Cetyl ethylhexanoate 4.0 4. Dimethicone 1.5 5. Squalane 4.0 6. Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 1.0 7. Potassium cetyl phosphate 1.0 8. Sorbitan Sesquioleate 0.8 9. Sucrose stearate 2.0 10. Polyglyceryl-10 Stearate 1.5 11. PEG-50 hydrogenated castor oil 1.0 12. Tocopherol 0.1 13.Water in moderation 14. 1,3-Butylene glycol 10.0 15. Hydroxypropyl methylcellulose stearoxy ether*5 0.1 16. Glycerin 15.0 17. Carbomer 0.1 18. EDTA-2Na 0.005 19. Iodopropynyl butylcarbamate 0.003 20. Ethylhexylglycerin 0.2 21. Niacinamide 4.0 22. Phenoxyethanol 0.2 23. Polymethylmethacrylate 2.0 24. Retinol Palmitate / Corn Oil Mixture 0.001 25.10% arginine aqueous solution 1.0 26. Sodium glutamate 0.01 27. Creatinine 0.01 28. Centella asiatica extract 0.01 29. Hibiscus Flower Extract 0.01 30. Hydrolyzed hyaluronic acid 0.01 31.Comfrey Leaf Extract 0.01 32. Hydrolyzed elastin 0.01 33. Hydrolyzed soy protein 0.01 34. Mandarin orange peel extract 0.01 35. Lactobacillus / fermented pear juice 0.01 36. Job's Tears Seed Extract 0.01 37. Alpinia speciosa leaf extract 0.01 Potassium cetyl phosphate AMPHISOL K*1 DSM Nutrition Hydroxypropyl methylcellulose stearoxy ether*5 Sangelose 60L: Daido Kasei Co., Ltd.

[0072] (Manufacturing method) (a): Dissolve and mix ingredients 1 to 12 uniformly at 70°C. (b): Dissolve and mix ingredients 13 to 24 uniformly at 80°C. (c): Add (a) to (b) and emulsify at 70°C. (d): After starting to cool (c), ingredients 25 to 37 were added successively at 45°C, and then cooled to 35°C to obtain an oil-in-water emulsion serum.

[0073] The all-in-one gel of Example 13 was a composition for external use on the skin that was excellent in skin firmness and elasticity, anti-stickiness, and crystal precipitation inhibitory effect, as well as stability over time.

[0074] Example 14: Oil-in-water emulsion serum (serum containing multiple extracts) (Component) (mass%) 1.1,3-Butylene glycol 9.0 2. Diglycerin 5.0 3. Maltose 3.0 4.Appropriate amount of purified water 5. Nicotinamide 4.0 6. Polyvinyl alcohol 0.1% 7. (Hydroxypropyl methylcellulose stearoxy ether *2 0.1 8. PEG-50 Hydrogenated Castor Oil 2.0 9. Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) 2.0 10. Diphenylsiloxyphenyl Trimethicone 3.0 11. Hydrogenated polyisobutene 3.0 12. Oleth-3 phosphate 0.2 13. Sorbitan Sesquioleate 0.8 14. Stearyl glycyrrhetinate 0.05 15. Tocopherol 0.1 16. Phenoxyethanol 0.2 17. Rose extract 0.01 18. Cherry blossom extract 0.01 19. Lily extract 0.01 20. Cape gooseberry extract 0.01 21. Zedoary extract 0.01 22.Tea extract 0.01 23. Rehmannia extract 0.01 24. Angelica extract 0.01 25. Hibiscus extract 0.01 26. Tormentilla extract 0.01 27. Baobab extract 0.01 28. Ireisen extract 0.01 29. Sunflower extract 0.01 30. Medicine grass extract 0.01 31. Licorice extract 0.01 32. Safflower extract 0.01 33. Ginseng extract 0.01 34. Job's tears extract 0.01 35. Horsetail extract 0.01 36. Ginkgo extract 0.01 37. Jojoba extract 0.01 38.Terminaria Extract 0.01 39. Chickweed extract 0.01 40. Corn extract 0.01 41. Hanaiguchi Extract 0.01 42. Pomegranate extract 0.01 43. Meshimakobu extract 0.01 44. Rosehip extract 0.01 45.Evening primrose extract 0.01 46. ​​Chamomile extract 0.01 47. Soybean extract 0.01 48. White bean extract 0.01 49. Tangerine extract 0.01 50. Mokutenryo extract 0.01 51. Black carrot extract 0.01 52. White strawberry extract 0.01 53. Himalayan Raspberry Extract 0.01 54. Silk tree extract 0.01 55.Sweet marjoram extract 0.01 56. Modama Extract 0.01 57.Comfrey Leaf Extract 0.01 58. Saccharomyces / Daylily Flower Ferment 0.01 59.Alpinia speciosa leaf extract 0.01 60. Berberisia arbutus fruit extract 0.01 61. Hibamata Extract 0.01 62. Hydrolyzed soy protein 0.01 63.Tabebuia impetiginosa bark extract 0.01 64. Glucosyl Hesperidin 0.01 Hydroxypropyl methylcellulose stearoxy ether *2 Sangelose 60L: Daido Kasei Co., Ltd. Oleth-3 phosphate Hostaphat O300*10 Clariant

[0075] (Manufacturing method) (a): Components 1 to 7 are uniformly dissolved and mixed at 70°C. (b): Dissolve and mix ingredients 8 to 16 uniformly at 80°C. (c): Add (b) to (a) and emulsify at 70°C. (d): After starting to cool (c), components 17 to 64 were added successively at 45°C, and then cooled to 35°C to obtain an oil-in-water emulsion serum.

[0076] The oil-in-water emulsion cosmetic serum of Example 14 was a composition for external use on the skin that was excellent in skin firmness and elasticity, anti-stickiness, and crystal precipitation inhibitory effects, as well as stability over time. [Industrial Applicability]

[0077] The present invention can be applied to cosmetics, quasi-drugs, external skin preparations, and the like.

Claims

1. The following components (A) to (D): (A) Nicotinamide 1 to 10% by mass (B) 0.05 to 2% by mass of a salt-resistant water-soluble polymer selected from one or more of cellulose derivatives, hydrophobically modified polyether urethanes, and copolymers containing acryloyldimethyltaurate salts as monomers. (C) A phosphate surfactant selected from one or more of higher alcohol phosphate salts and higher alcohol ethylene oxide adduct phosphate salts. (D) Polyhydric alcohol: 5 to 25% by mass A composition for topical application to the skin comprising the compound.

2. The blending mass ratio of component (D) and component (A) is The composition for external use on skin according to claim 1, wherein (D) / (A) is ≧2.

3. 3. The composition for external use on skin according to claim 1 or 2, wherein the salt-resistant water-soluble polymer of component (B) is one or more selected from the group consisting of hydroxypropyl methylcellulose stearoxy ether, (PEG-240 / decyltetradeceth-20 / HDI) copolymer, (sodium acrylate / sodium acryloyldimethyltaurate) copolymer, (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer, and (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer.

4. A sheet-shaped external preparation for skin impregnated with the composition for external use for skin according to any one of claims 1 to 3.

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