External use ingredients

Abstract

To provide an external composition for foam dispensers that is excellent in foamability and the persistence of the bubbles, while enabling the bubbles to run out quickly.SOLUTION: An external composition for foam dispensers contains (A1 component) a sugar alcohol with 4 or more carbon atoms, and (B component) a nonionic surfactant having an oxyalkylene unit.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to compositions for external use. [Background technology]

[0002] The dosage forms of topical agents include, for example, ointments, creams, lotions, etc. Ointments and creams are semi-solid and therefore difficult to spread over a wide area. Lotions are liquid and therefore suitable for spreading over a wide area, but are difficult to use because the liquid may drip during use.

[0003] Meanwhile, in recent years, foam agents that are simple and can be used in a wide range of applications have been attracting attention. When foam agents are discharged, they are in a foam state, so dripping is suppressed, and since they are liquid, they are also suitable for spreading over a wide range. As foam agents, foam agents using a non-gas type foam discharge device such as a pump type foam discharge device that uses a non-ionic surfactant for the purpose of suppressing irritation to the skin are preferable. Patent Document 1 proposes that foam can be maintained for a long time by combining a non-ionic surfactant with a certain amount or more of alcohol. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2016-121146 A Summary of the Invention [Problem to be solved by the invention]

[0005] In the course of research, the inventor noticed that although foam agents of the prior art have good foam durability and suppress dripping, they have the problem that the foam does not disappear easily even when spread, and the spread area appears white (the problem of poor foam removal).

[0006] Therefore, an object of the present invention is to provide a composition for external use for a foam-ejecting device that has good foaming and foam persistence while also having good foam-breaking properties. [Means for solving the problem]

[0007] In view of the above problems, the present inventors have conducted intensive research and found that the above problems can be solved by a composition for external use for a foam ejection device, which contains (A1 component) a sugar alcohol having 4 or more carbon atoms and (B component) a nonionic surfactant containing an oxyalkylene unit. Based on this finding, the present inventors have conducted further research and completed the present invention. That is, the present invention includes the following aspects.

[0008] Item 1. A composition for external use for a foam ejection device, comprising (Component A1) a sugar alcohol having 4 or more carbon atoms, and (Component B) a nonionic surfactant containing an oxyalkylene unit. Item 2. The composition for external use according to Item 1, wherein the component A1 contains a sugar alcohol having 4 to 6 carbon atoms. Item 3. The composition for external use according to Item 1 or 2, wherein the component A1 comprises at least one member selected from the group consisting of sorbitol, mannitol, and erythritol. Item 4. The composition for external use according to any one of Items 1 to 3, wherein the content of the A1 component in the composition for external use is 0.1 to 40% by mass. Item 5. The composition for external use according to any one of Items 1 to 4, further comprising (Component A2) at least one selected from the group consisting of glycerin and glycerin polymers. Item 6. The composition for external use according to Item 5, wherein the content of the component A2 in the composition for external use is 0.5 to 45% by mass. Item 7. The composition for external use according to any one of Items 1 to 6, wherein the content of 1,3-butylene glycol in the composition for external use is less than 5% by mass. Item 8. The composition for external use according to any one of Items 1 to 7, wherein the total content of the component A1 and (component A2) at least one selected from the group consisting of glycerin and glycerin polymers in the polyhydric alcohol is 80% by mass or more. Item 9. The composition for external use according to any one of Items 1 to 8, wherein Component B comprises a nonionic surfactant containing at least one selected from the group consisting of an oxyethylene unit and an oxypropylene unit. Item 10. The composition for external use according to any one of Items 1 to 9, wherein Component B comprises at least one member selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, polyoxyalkylene hydrogenated castor oil, and polyoxyalkylene alkyl ether. Item 11. The composition for external use according to any one of Items 1 to 10, wherein Component B comprises at least one member selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, and polyoxyalkylene hydrogenated castor oil. Item 12. The composition for external use according to any one of Items 1 to 11, wherein the content of the component B in the composition for external use is 0.05 to 10% by mass. Item 13. The composition for external use according to any one of Items 1 to 12, wherein the content of component B in the surfactant is 80% by mass or more. Item 14. The composition for external use according to any one of Items 1 to 13, which contains a medicinal ingredient. Item 15. The composition for external use according to Item 14, wherein the active ingredient is at least one selected from the group consisting of moisturizing agents, anti-inflammatory agents, vitamins, antibacterial agents, and skin whitening agents. Item 16. The composition for external use according to any one of Items 1 to 15, wherein the water content in the composition for external use is 25% by mass or more. Item 17. The composition for external use according to any one of Items 1 to 16, which is intended for application to the skin. Item 18. The composition for external use according to any one of Items 1 to 17, wherein the foam ejection device is a non-gas type foam ejection device. Item 19. An external preparation comprising the composition for external use according to any one of items 1 to 18 packed in a container equipped with a foam ejection device. Effect of the Invention

[0009] According to the present invention, it is possible to provide a composition for external use for a foam ejection device, which has good foaming and foam persistence, while also having good foam rinsing properties. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] In this specification, the expressions "contain" and "comprise" include the concepts of "contain", "include", "consist essentially of" and "consist only of".

[0011] In one aspect, the present invention relates to a composition for external use for a foam ejection device (sometimes referred to as the "composition for external use of the present invention" in this specification) that contains (A1 component) a sugar alcohol having 4 or more carbon atoms and (B component) a nonionic surfactant containing an oxyalkylene unit. This will be described below.

[0012] The sugar alcohol (A1 component) having 4 or more carbon atoms is not particularly limited as long as it is a sugar alcohol and has 4 or more carbon atoms constituting the molecule. The sugar alcohol is typically one generated by reduction of aldose (alditol, preferably D-alditol). The number of carbon atoms of the sugar alcohol is preferably 4 to 7, more preferably 4 to 6, even more preferably 5 to 6, and even more preferably 6, from the viewpoints of foaming, foam persistence, foam breaking, etc. Examples of sugar alcohols having 4 or more carbon atoms include tetritol (C4H6(OH)4) such as erythritol and threitol; pentitol (C5H7(OH)5) such as arabinitol, xylitol, and ribitol; hexitol (C6H8(OH)6) such as allitol, iditol, galactitol, sorbitol, and mannitol; and heptitol (C7H9(OH)7) such as volemitol and perseitol. In one embodiment of the present invention, among these, from the viewpoints of foaming, foam durability, foam breaking down, etc., preferred are sorbitol, mannitol, erythritol, etc., and more preferred (particularly from the viewpoint of foam durability) are sorbitol, mannitol, etc.

[0013] The component A1 may be used alone or in any combination of two or more kinds.

[0014] In one embodiment of the present invention, the A1 component preferably contains a sugar alcohol having 4 to 6 carbon atoms. In addition, in one embodiment of the present invention, the A1 component preferably contains at least one selected from the group consisting of sorbitol, mannitol, and erythritol.

[0015] The content of the A1 component in the topical composition of the present invention is not particularly limited as long as it can exhibit good foaming, foam persistence, and foam breaking. The content is, for example, 0.1 to 40% by mass. From the viewpoints of foaming, foam persistence, foam breaking, etc., the content is preferably 0.2 to 40% by mass, more preferably 0.4 to 35% by mass, and even more preferably 0.5 to 30% by mass. From the viewpoints of foaming, foam persistence, foam breaking, etc., in a preferred embodiment of the present invention, the lower limit of the content may be, for example, 1% by mass, 2% by mass, 3% by mass, 4% by mass, 5% by mass, 6% by mass, 7% by mass, 8% by mass, 9% by mass, or 10% by mass.

[0016] From the viewpoints of foaming, foam durability, foam breaking down, and the like (particularly foam durability), the topical composition of the present invention preferably contains at least one member selected from the group consisting of glycerin and glycerin polymers (component A2).

[0017] The glycerin polymer is not particularly limited as long as it is formed by polymerizing two or more glycerins. Examples of the glycerin polymer include diglycerin and polyglycerin, and from the viewpoint of foam-breaking, polyglycerin is preferable. The glycerin polymerization number of polyglycerin is, for example, 3 to 30, and from the viewpoints of foaming, foam persistence, foam-breaking, etc., it is preferably 5 to 20, more preferably 7 to 15, and even more preferably 8 to 12.

[0018] As the component A2, from the viewpoints of foaming, foam durability, foam breaking down, and the like (particularly foam breaking down), preferred examples include glycerin, polyglycerin, and the like, and more preferred examples include glycerin.

[0019] The component A2 may be used alone or in any combination of two or more kinds.

[0020] In one embodiment of the present invention, component A2 preferably contains at least one selected from the group consisting of glycerin and polyglycerin, and more preferably contains glycerin.

[0021] When the topical composition of the present invention contains the A2 component, the content of the A2 component in the topical composition of the present invention is not particularly limited as long as it can exhibit good foaming, foam persistence, and foam-breaking properties. The content is, for example, 0.5 to 45% by mass. From the viewpoints of foaming, foam persistence, foam-breaking properties, etc., the content is preferably 1 to 45% by mass, more preferably 2 to 40% by mass, even more preferably 4 to 35% by mass, even more preferably 6 to 30% by mass, particularly preferably 6 to 25% by mass, and particularly preferably 8 to 25% by mass.

[0022] When the topical composition of the present invention contains component A2, the total content of components A1 and A2 in the topical composition of the present invention is preferably 1 to 85% by mass, more preferably 2 to 75% by mass, even more preferably 4 to 70% by mass, still more preferably 5 to 65% by mass, particularly preferably 7 to 55% by mass, and particularly preferably 9 to 50% by mass, from the viewpoints of foaming, foam persistence, foam breaking, etc. In one embodiment of the present invention, the lower limit of the content may be, for example, 12% by mass, 14% by mass, 16% by mass, 18% by mass, or 19% by mass.

[0023] When the topical composition of the present invention contains component A2, the content ratio of component A1 to component A2 in the topical composition of the present invention is preferably 0.05 to 45 parts by mass, more preferably 0.1 to 40 parts by mass, even more preferably 0.2 to 35 parts by mass, and even more preferably 0.3 to 30 parts by mass of component A2 per part by mass of component A1, from the viewpoints of foaming, foam persistence, foam breaking down, etc. In a further preferred embodiment of the present invention, the content of component A2 per part by mass of component A1 is preferably 0.4 to 10 parts by mass, 0.5 to 5 parts by mass, 0.6 to 3 parts by mass, or 0.8 to 2 parts by mass.

[0024] In one embodiment of the present invention, the topical composition of the present invention may contain other polyhydric alcohols other than the A1 and A2 components. Examples of other polyhydric alcohols include propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,3,6-hexanetriol, polyethylene glycol, and polypropylene glycol. However, in this case, from the viewpoints of foaming, foam persistence, foam break-up, and the like, it is preferable that the content of other polyhydric alcohols is lower.

[0025] The other polyhydric alcohols may be used alone or in any combination of two or more kinds.

[0026] In the topical composition of the present invention, the total content of the A1 component and the A2 component in the polyhydric alcohol (when the topical composition of the present invention does not contain the A2 component, this means the content of the A1 component) is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, even more preferably 90% by mass or more, even more preferably 95% by mass or more, particularly preferably 97% by mass or more, especially preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.

[0027] In one aspect of the present invention, the composition for external use of the present invention preferably has a lower content of other polyhydric alcohols (for example, at least one polyhydric alcohol selected from the group consisting of 1,3-butylene glycol, macrogol 400, and 1,3,6-hexanetriol) from the viewpoints of foaming, foam persistence, foam breaking, etc. The content of the polyhydric alcohol (for example, 1,3-butylene glycol) in the composition for external use of the present invention is, for example, 0% by mass or more and less than 5% by mass, preferably 0% by mass or more and less than 4% by mass, more preferably 0% by mass or more and less than 3% by mass, even more preferably 0% by mass or more and less than 2% by mass, even more preferably 0% by mass or more and less than 1% by mass, particularly preferably 0% by mass or more and less than 0.5% by mass, particularly more preferably 0% by mass or more and less than 0.1% by mass, and even more preferably 0% by mass or more and less than 0.01% by mass. In one aspect of the present invention, the content can be 0% by mass.

[0028] The nonionic surfactant containing an oxyalkylene unit (component B) is not particularly limited as long as it is a nonionic surfactant having an oxyalkylene unit (a homopolymer chain of alkylene oxide) in the molecule. The oxyalkylene unit can be present in a plurality of separate units. The number of carbon atoms of the "alkylene" is, for example, 2 to 4, preferably 2 to 3. The average number of moles of alkylene oxide added in the oxyalkylene unit is not particularly limited, but is, for example, 10 to 300, preferably 25 to 250, more preferably 35 to 200.

[0029] As the B component, from the viewpoints of foaming, foam persistence, foam breaking, etc., a nonionic surfactant containing at least one selected from the group consisting of an oxyethylene unit and an oxypropylene unit is preferred. The nonionic surfactant is not particularly limited as long as it is a nonionic surfactant having an oxyethylene unit (a homopolymer chain of ethylene oxide) and / or an oxypropylene unit (a homopolymer chain of propylene oxide) in the molecule. The average number of moles of ethylene oxide added in the oxyethylene unit is not particularly limited, but is, for example, 10 to 300, preferably 25 to 250, and more preferably 35 to 200. The average number of moles of propylene oxide added in the oxypropylene unit is not particularly limited, but is, for example, 10 to 300, preferably 20 to 200, and more preferably 25 to 100.

[0030] Examples of the nonionic surfactant which is component B include polyoxyethylene polyoxypropylene glycol; polyoxyalkylene fatty acid esters such as polyoxyethylene fatty acid esters (for example, polyethylene glycols of monofatty acids (saturated or unsaturated fatty acids) having C12 to C24, preferably C16 to C20); polyoxyalkylene hydrogenated castor oils such as polyoxyethylene hydrogenated castor oil; polyoxyethylene lauryl ether, polyoxyethylene oleyl ether, polyoxyethylene decyl ether, polyoxyalkylene decyl ether, and other polyoxyalkylene hydrogenated castor oil ethers; polyoxyalkylene hydrogenated castor oil ethers such as polyoxyethylene hydrogenated castor oil ether; polyoxyalkylene glyceryl ether fatty acid esters such as polyoxyethylene glyceryl ether fatty acid esters; and polyoxyethylene sorbitan fatty acid esters. Among these, from the viewpoints of foaming, foam persistence, foam breaking-off, and the like, preferred are polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid esters, polyoxyalkylene hydrogenated castor oil, polyoxyalkylene alkyl ethers, and the like, more preferred are polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid esters, polyoxyalkylene hydrogenated castor oil, and the like, even more preferred are polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid esters, and the like, and even more preferred is polyoxyethylene polyoxypropylene glycol.

[0031] The HLB value of the nonionic surfactant, which is the component B, is not particularly limited as long as it can exhibit good foaming, foam persistence, and foam removal. The HLB value is, for example, 10 to 20, and preferably 12 to 18.

[0032] The component B may be used alone or in any combination of two or more.

[0033] In one embodiment of the present invention, the B component preferably contains a nonionic surfactant containing at least one selected from the group consisting of an oxyethylene unit and an oxypropylene unit.In addition, in one embodiment of the present invention, the B component more preferably contains at least one selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, polyoxyalkylene hydrogenated castor oil, and polyoxyalkylene alkyl ether.In addition, in one embodiment of the present invention, the B component more preferably contains at least one selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, and polyoxyalkylene hydrogenated castor oil.

[0034] The content of the B component in the composition for external use of the present invention is not particularly limited as long as it can exhibit good foaming, foam persistence, and foam breaking. The content is, for example, 0.02 to 15% by mass. From the viewpoints of foaming, foam persistence, foam breaking, etc., the content is preferably 0.05 to 12% by mass, more preferably 0.05 to 10% by mass, even more preferably 0.1 to 9% by mass, even more preferably 0.2 to 9% by mass, particularly preferably 0.3 to 9% by mass, and particularly preferably 0.4 to 9% by mass. From the viewpoints of foaming, foam persistence, foam breaking, etc., in a preferred embodiment of the present invention, the upper limit of the content may be, for example, 8% by mass, 7% by mass, 6% by mass, 5% by mass, 4% by mass, 3% by mass, 2% by mass, 1% by mass, or 0.8% by mass.

[0035] In one embodiment of the present invention, the composition for external use of the present invention can contain other surfactants other than component B. Examples of other surfactants include nonionic surfactants such as glycerin fatty acid esters, sorbitan fatty acid esters, and aliphatic alkanolamides; anionic surfactants; cationic surfactants; amphoteric surfactants, etc. However, in this case, from the viewpoints of skin irritation, foaming, foam persistence, and foam breakage, it is preferable that the content of other surfactants is lower.

[0036] The other surfactants may be used alone or in any combination of two or more.

[0037] In the composition for external use of the present invention, the content of the B component in the surfactant is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, even more preferably 90% by mass or more, even more preferably 95% by mass or more, particularly preferably 97% by mass or more, particularly preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.

[0038] In the composition for external use of the present invention, the content of the B component in the nonionic surfactant is, for example, 70% by mass or more, preferably 80% by mass or more, more preferably 85% by mass or more, even more preferably 90% by mass or more, even more preferably 95% by mass or more, particularly preferably 97% by mass or more, especially preferably 98% by mass or more, and particularly preferably 99% by mass or more. The content is 100% by mass or less.

[0039] The content of other surfactants (particularly, anionic surfactants, cationic surfactants, and amphoteric surfactants) in the composition for external use of the present invention is, for example, 0% by mass or more and less than 5% by mass, preferably 0% by mass or more and less than 4% by mass, more preferably 0% by mass or more and less than 3% by mass, even more preferably 0% by mass or more and less than 2% by mass, even more preferably 0% by mass or more and less than 1% by mass, particularly preferably 0% by mass or more and less than 0.5% by mass, particularly preferably 0% by mass or more and less than 0.1% by mass, and even more preferably 0% by mass or more and less than 0.01% by mass.In one embodiment of the present invention, the content can be 0% by mass.

[0040] In one embodiment of the present invention, the composition for external use of the present invention may contain a medicinal ingredient. The medicinal ingredient is preferably a water-soluble medicinal ingredient. Examples of the medicinal ingredient include a moisturizer, an anti-inflammatory agent, a vitamin, an antibacterial agent, and a skin-whitening agent.

[0041] Examples of moisturizing agents include biopolymers such as heparinoids, heparin or its salts, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, and keratin; amino acids such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; and plant extracts such as lavender extract, eucalyptus extract, and peppermint extract.

[0042] Examples of anti-inflammatory agents include glycyrrhizinic acid, glycyrrhizinic acid derivatives such as dipotassium glycyrrhizinate and monoammonium glycyrrhizinate, glycyrrhetinic acid or a derivative thereof, allantoin or a derivative thereof, tranexamic acid or a salt thereof, ε-aminocaproic acid, licorice extract, menthol, camphor, and the like. Examples of vitamin preparations include vitamin C such as ascorbic acid and its sodium salts; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid derivatives such as ascorbic acid phosphate salts, such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, palmitoyl ascorbic acid phosphate sodium salt, and tocopheryl ascorbyl phosphate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, flavin adenine dinucleotide, cyanocobalamin, folates, nicotinic acids such as nicotinic acid and nicotinamide, and cholines; other vitamins such as pantothenic acid, panthenyl ethyl ether, panthenol, biotin, and other water-soluble vitamin E salts.

[0043] Examples of antibacterial agents include isopropylmethylphenol, chlorhexidine hydrochloride, benzalkonium chloride, cetylpyridinium chloride, ethanol, paraben, and phenoxyethanol.

[0044] Examples of whitening agents include hydroquinone, α-arbutin, β-arbutin, ascorbic acid, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, 3-O-cetyl ascorbic acid, ascorbyl tetra-2-hexyldecyl decanoate, methylsilanol ascorbate, ascorbyl sulfate, ascorbyl glucoside, potassium (ascorbyl / tocopheryl) phosphate, ascorbyl phosphate, ascorbyl palmitate, ascorbyl dipalmitate, trisodium ascorbyl palmitate phosphate, aminopropyl ascorbyl phosphate, ascorbyl stearate, dehydroascorbic acid, disodium ascorbyl sulfate, calcium ascorbate, magnesium ascorbate, sodium ascorbate, zinc ascorbate, chitosan ascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, trisodium ascorbyl phosphate, kojic acid, rucinol, and tranexamic acid.

[0045] The medicinal components may be used alone or in any combination of two or more.

[0046] When the topical composition of the present invention contains a medicinal ingredient, the content of the medicinal ingredient in the topical composition of the present invention is not particularly limited as long as it can exert its medicinal effect and does not significantly impair foaming, foam persistence, foam breakage, etc. The content is, for example, 0.0001 to 10% by mass, 0.001 to 3% by mass, or 0.01 to 1% by mass.

[0047] In one embodiment of the present invention, the topical composition of the present invention can contain other components other than those mentioned above.Other components include, for example, ester oils (e.g., triacetin, triethyl citrate, tri(caprylic, capric)glycerin, diisopropyl adipate, diethyl adipate, diethyl sebacate, etc. dibasic acids, isopropyl myristate, cetyl palmitate, hexyl laurate, benzyl acetate, etc. monobasic acids), hydrocarbons (e.g., liquid paraffin, squalane, etc.), solvents (e.g., benzyl alcohol, methyl ethyl ketone, N-alkylpyrrolidone, alkylene carbonate, acetone, ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, etc.), water-soluble polymers (e.g., carboxyvinyl polymer, hydroxymethylcellulose, hydroxypropylcellulose, methylcellulose, chitosan, povidone, polyvinyl alcohol, etc.), preservatives, preservatives, stabilizers, etc.

[0048] The content of other components in the topical composition of the present invention is not particularly limited as long as it does not significantly impair foaming, foam persistence, foam breaking down, etc. The content is, for example, 0 to 10% by mass, 0 to 5% by mass, 0 to 2% by mass, 0 to 1% by mass, or 0 to 0.1% by mass.

[0049] The composition for external use of the present invention usually contains water from the viewpoint of foaming, foam persistence, foam breaking, etc. The content of water in the composition of the present invention is, for example, 15% by mass or more, preferably 20% by mass or more, more preferably 25% by mass or more, even more preferably 30% by mass or more, even more preferably 35% by mass or more, particularly preferably 40% by mass or more, especially more preferably 50% by mass or more, and especially more preferably 60% by mass or more. The upper limit of the content can be, for example, 95% by mass, 90% by mass, 85% by mass, or 80% by mass. The above lower limit and upper limit can be arbitrarily combined.

[0050] The topical composition of the present invention can be applied to the skin. The topical composition of the present invention has good foam durability, so it is easy to spread because it suppresses dripping when discharged in foam form and has good foam breakage. The topical composition of the present invention is preferably in the form of a topical composition for skin such as a skin topical medicine or cosmetic. The topical composition of the present invention is used in a form that is not removed after application, and is distinguished from a cleanser that is intended to be removed (e.g., washed off) with water after foaming.

[0051] The composition for external use of the present invention can be prepared by mixing each component with a solvent. The composition of the present invention is preferably in a solubilized state. The solubilized state refers to a state in which the surfactant forms micelles, and the substance that is not dissolved in the solvent is transparent and uniformly dissolved to form a one-phase solution. The solubilized state also includes a microemulsion state. A microemulsion is a thermodynamically stable micellar solution consisting of emulsion particles with a fine particle size of 100 nm or less. The solubilized state can be confirmed by the transparent appearance. The solubilized state can also be confirmed by measuring the particle size by a conventional method. The solubilized composition can be obtained by dissolving each component under heating as necessary, and then cooling.

[0052] The composition for external use of the present invention is a composition for a foam discharge device. Here, the foam discharge device means one equipped with a foaming mechanism. That is, the composition for external use of the present invention is intended to be foamed by a foam discharge device for use. The foam discharge device is preferably a non-gas type foam discharge device from the viewpoint of skin irritation. An example of a non-gas type foam discharge device is a screen type foam discharge device. The screen type foam discharge device means a device that pressurizes a liquid, passes it through a net-like screen, and mixes it with air to foam it. Examples of the screen type foam discharge device include a pump type foam discharge device, a tube type foam discharge device, and a squeeze type foam discharge device. Among these, a pump type foam discharge device is preferable.

[0053] The foam discharge device may be a known device, a commercially available device, etc. For example, in the case of a pump-type foam discharge device, the devices described in JP-A-2012-45525, JP-A-2008-307478, etc. may be used.

[0054] The topical composition of the present invention can be used by filling it in a container equipped with a foam ejection device. From this viewpoint, in one aspect, the present invention also relates to an external preparation comprising the topical composition of the present invention filled in a container equipped with a foam ejection device. The "topical preparation" is the same as the topical composition of the present invention described above. EXAMPLES

[0055] The present invention will be described in detail below based on examples, but the present invention is not limited to these examples.

[0056] Test Example 1. Foam Evaluation Test 1 Compositions 1 to 16 were prepared for filling into a container equipped with a foam discharge device according to the formulations shown in Tables 1 and 2 (numbers in parts by mass). Specifically, each component was weighed, heated and dissolved at 80°C, and solubilized under stirring, and then cooled to room temperature while stirring to obtain compositions 1 to 16. These compositions were filled into a pump-type foam discharge device container and subjected to testing.

[0057] Details of the materials used are as follows: 70% D-sorbitol solution (prepared by dissolving D-sorbitol (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., product name: D-sorbitol (Wako First Grade)) in purified water) Mannitol (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., product name: D-Mannitol (Wako Special Grade)) Erythritol (Tokyo Chemical Industry Co., Ltd., product name: meso-erythritol) Glycerin (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., product name: Glycerin (special grade reagent)) Polyglycerin (manufactured by Sakamoto Pharmaceutical Co., Ltd., product name: Polyglycerin 750, glycerin polymerization number: 10) Polyoxyethylene polyoxypropylene glycol (NOF Corporation, product name: Pronon 188P) Polyethylene glycol monostearate (manufactured by Nikko Chemicals, product name: MYS-40MV) Polyoxyethylene hydrogenated castor oil (manufactured by Nikko Chemicals, product name: HCO-60 (pharmaceutical product)).

[0058] A fixed amount of each of compositions 1 to 16 was discharged onto a slide glass from a pump-type foam discharge device container. The foaming immediately after discharge was observed visually and rated on a four-point scale according to the following evaluation criteria. The foam persistence was also evaluated visually on the change in the state of the foam after leaving it to stand for 5 minutes after discharge and rated on a four-point scale according to the following evaluation criteria. With regard to the foaming immediately after discharge, an evaluation of ○ or higher was judged to be good foaming, and with regard to the foam persistence, an evaluation of △ or higher was judged to be good persistence.

[0059] <Evaluation criteria for foaming immediately after dispensing> ◎: Good quality foam (fine, foamy). ○: Foams. △: Weak foaming. ×: No foam is formed.

[0060] <Evaluation criteria for foam durability> ◎: No change in foam is observed. ○: The foam height is decreased. △: The area occupied by the bubbles on the slide glass becomes smaller. ×: No bubbles.

[0061] On the other hand, a certain amount of each of compositions 1 to 16 was discharged from a pump-type foam discharge device container onto one arm of the subject, and the subject spread the composition toward the fingertips. However, the subject was only allowed to spread the composition once. The foam-breakdown was evaluated on a three-point scale according to the following evaluation criteria. A rating of △ or higher was determined to be good.

[0062] <Evaluation criteria for foam loss> ○: After spreading once, foam was found to remain on the arm, but the foam disappeared within 1 minute. △: After spreading once, foam was found to remain on the arm, and the foam was still there after 1 minute. However, by spreading repeatedly, the foam disappeared, and no whitening was observed. ×: After spreading once, bubbles were found to remain on the arm. Even after spreading several times, bubbles remained and whitening was found on the arm.

[0063] The results are shown in Tables 1 and 2.

[0064] [Table 1]

[0065] [Table 2]

[0066] As shown in Tables 1 and 2, the foams obtained from compositions 1 to 16 had good foaming and foam persistence, and also had good foam-breaking properties.

[0067] Test Example 2. Foam Evaluation Test 2 According to the formulations shown in Table 3 (numbers in parts by mass), compositions 17 to 18 for filling into a container equipped with a foam ejection device were prepared in the same manner as in Test Example 1. The foaming immediately after ejection, foam persistence, and foam disappearance were evaluated in the same manner as in Test Example 1.

[0068] The results are shown in Table 3.

[0069] [Table 3]

[0070] As shown in Table 3, the foams obtained from Compositions 17 to 18 had good foaming and foam persistence, and also had good foam-rinsing properties.

Claims

1. A composition for topical use, comprising: The composition comprises (A1 component) a sugar alcohol having 4 to 7 carbon atoms, (A2 component) at least one selected from the group consisting of glycerin and glycerin polymers having a polymerization number of 2 to 30, (B component) a nonionic surfactant having an HLB value of 10 to 20 and including at least one selected from the group consisting of an oxyethylene unit and an oxypropylene unit, and water; The content of the A1 component in the topical composition is 0.1 to 40% by mass, The content of the A2 component in the topical composition is 4 to 45% by mass, The content of the component B in the topical composition is 0.02 to 15% by mass, The content of the water in the topical composition is 15 to 95% by mass, The content of surfactants other than the component B in the topical composition is 0% by mass or more and less than 5% by mass, and The content of 1,3-butylene glycol in the topical composition is less than 5% by mass. A topical composition for use with a foam dispensing device.

2. The composition for external use according to claim 1, wherein the A1 component comprises a sugar alcohol having 4 to 6 carbon atoms.

3. The composition for external use according to claim 1 or 2, wherein the component A1 comprises at least one selected from the group consisting of sorbitol, mannitol, and erythritol.

4. The composition for external use according to any one of claims 1 to 3, wherein the content of the A1 component in the composition for external use is 0.2 to 40 mass%.

5. The composition for external use according to any one of claims 1 to 4, wherein the component A2 comprises at least one member selected from the group consisting of glycerin and polyglycerin having a polymerization number of 3 to 30.

6. The composition for external use according to any one of claims 1 to 5, wherein the content of the A2 component in the composition for external use is 4 to 35 mass%.

7. The topical composition according to any one of claims 1 to 6, wherein the content of 1,3-butylene glycol in the topical composition is less than 3% by mass.

8. The composition for external use according to any one of claims 1 to 7, wherein the total content of the A1 component and the A2 component in the polyhydric alcohol is 80 mass% or more.

9. The composition for external use according to any one of claims 1 to 8, wherein the HLB value of the B component is 12 to 18.

10. The composition for external use according to any one of claims 1 to 9, wherein the component B comprises at least one selected from the group consisting of polyoxyethylene polyoxypropylene glycol, polyoxyalkylene fatty acid ester, polyoxyalkylene hydrogenated castor oil, and polyoxyalkylene alkyl ether.

11. The composition for external use according to any one of claims 1 to 10, wherein the content of component B in the composition for external use is 0.05 to 10% by mass.

12. The composition for external use according to any one of claims 1 to 11, wherein the content of component B in the surfactant is 97% by mass or more.

13. The composition for external use according to any one of claims 1 to 12, which contains a medicinal ingredient.

14. The composition for external use according to any one of claims 1 to 13, wherein the content of said water in said composition for external use is 25 to 95% by mass.

15. An external preparation comprising the composition for external use according to any one of claims 1 to 14 packed in a container equipped with a foam ejection device.

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