Sensor unit and measuring instrument

Abstract

In a measurement system in which a sensor unit and a measuring instrument are configured separately, sensor sensitivity is stabilized and the reproducibility of measurement results is improved. 【Solution means】A sensor unit configured to be detachable from a measuring instrument for performing electrochemical measurement, comprising a first cell for temporarily storing a test solution supplied from the outside, and a second cell containing a sensor electrode, wherein the supply of the test solution from the inside of the first cell to the inside of the second cell is configured to be triggered by the attachment of the sensor unit to the measuring instrument.

Description

Technical Field

[0001] The present invention relates to a sensor unit and a measuring instrument.

Background Art

[0002] There is known a measurement system that performs a voltage sweep operation or the like on a sensor electrode in contact with a test solution such as a body fluid to advance a predetermined reaction and measures the concentration of a specific component contained in the solution. In particular, in recent years, for the purpose of improving convenience and the like, research and development of a system in which a sensor unit including a sensor electrode and a measuring instrument that applies a voltage (sweep or the like) to the sensor electrode are configured separately has been promoted (see, for example, Patent Document 1 and Patent Document 2).

[0003] This separate system has various advantages for users, such as being excellent in handling because the sensor unit is configured to be detachable from the measuring instrument, facilitating the replacement and disposable use of the sensor unit, expecting cost reduction of the sensor unit by mass production, and enabling multiple users to share the measuring instrument.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in the above-described system, after the test liquid is brought into contact with the sensor unit, the measurement by the measuring instrument is not always started immediately thereafter. After the test liquid is brought into contact with the sensor unit, the sensor unit may be left unattended for, for example, several minutes to several hours until the measurement by the measuring instrument is performed. Thus, when the sensor unit is left unattended with the test liquid adhering to the sensor electrode, components (such as proteins) in the test liquid may adhere to the working surface of the sensor electrode, which may greatly vary the sensor sensitivity. Also, the amount of variation in this sensitivity may vary greatly depending on the length of the unattended time, environmental conditions, and the like. For these reasons, in the above-described separate-type measurement system, stabilizing the sensor sensitivity and improving the reproducibility of the measurement results have newly emerged as problems.

[0006] The present invention has been made in view of the above problems, and an object of the present invention is to provide a technique for stabilizing sensor sensitivity and improving the reproducibility of measurement results in a measurement system in which a sensor unit including a sensor electrode and a measuring instrument that performs electrochemical measurement on the sensor unit are separately configured.

Means for Solving the Problems

[0007] One aspect of the present invention is a sensor unit configured to be detachable from a measuring instrument for performing electrochemical measurement, a first cell for temporarily storing a test liquid supplied from the outside, a second cell containing a sensor electrode, and a sensor unit configured such that the supply of the test liquid from the first cell into the second cell is triggered by attaching the sensor unit to the measuring instrument.

Effects of the Invention

[0008] According to the present invention, in a measurement system in which a sensor unit and a measuring instrument that performs electrochemical measurement on the sensor unit are separately configured, it is possible to stabilize the sensor sensitivity and improve the reproducibility of the measurement results.

Brief Description of the Drawings

[0009]

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DETAILED DESCRIPTION OF THE INVENTION

[0010] <One Embodiment of the Present Invention> Hereinafter, one embodiment of the present invention will be described. Hereinafter, the measurement system, the sensor unit, and the measuring instrument of this embodiment will be described respectively.

[0011] (1) System Configuration As shown in FIG. 1(a), for example, the measurement system 1 of this embodiment includes a sensor unit 100, a measuring instrument 200, and a determination support device 300. The measurement system 1 is configured to measure the concentrations and the like of various components (specific substances, test substances) contained in a test liquid, and to output determination result data and the like indicating the health state of the subject based on the results.

[0012] The test liquid is not particularly limited, and examples thereof include various body fluids such as urine, saliva, sputum, nasal discharge, tears, sweat, and blood. When the test liquid is urine, examples of the specific substances include urea, ammonia, creatinine, uric acid, amino acids, ascorbic acid, phosphorus, oxalic acid, nitrite, sodium, potassium, calcium, protein, urine sugar, ketone bodies, bilirubin, urobilinogen, cytokines, cortisol, red blood cells, white blood cells, platelets, and the like.

[0013] (Sensor Unit) As shown in Fig. 1(b), the sensor unit 100 is portable and can be carried by hand by the subject, and is detachably configured with the measuring instrument 200. As will be described later, when the test liquid is poured while the sensor unit 100 is detached from the measuring instrument 200, the sensor unit 100 is configured to isolate the test liquid from the sensor electrode 40 while storing the test liquid. On the other hand, when the sensor unit 100 is attached to the measuring instrument 200, it is configured to bring the test liquid into contact with the sensor electrode 40 using the attachment as a trigger. In this specification, the structure in which the test liquid comes into contact with the sensor electrode 40 when the sensor unit 100 is attached to the measuring instrument 200 is called a trigger structure.

[0014] Here, the sensor unit 100 will be specifically described with reference to Figs. 2 and 3. Here, the case where the sensor unit 100 includes a vent tube 60 as a trigger mechanism will be described as an example. Fig. 2(a) is a top view showing a schematic configuration of a sensor unit according to an embodiment, and Fig. 2(b) is a cross-sectional view thereof. Fig. 3(a) is a view when the test liquid is poured onto the detached sensor unit, and Fig. 3(b) is a view of the sensor unit attached to the measuring instrument.

[0015] As shown in Fig. 2(a), the sensor unit 100 mainly includes a base material 10, a first cell 20 provided on one main surface of the base material 10, a second cell 30, a sensor electrode 40 enclosed in the second cell 30, a flow path 50 that communicates the inside of the first cell 20 and the inside of the second cell 30, and a vent tube 60 that is connected to the second cell 30 and acts as a trigger structure. Note that Fig. 2(a) shows the case where the first cell 20, the second cell 30, the flow path 50, the vent tube 60, etc. are provided on the same main surface, but they may be provided on different main surfaces.

[0016] The base material 10 is configured to support the first cell 20, the second cell 30, the sensor electrode 40, the flow path 50, and the vent tube 60 on one of the two main surfaces. The base material 10 is formed of a sheet-like or plate-like member and has a longitudinal shape.

[0017] The base material 10 has a physical (mechanical) strength that can be used as the sensor unit 100, for example, even when a test solution (urine) adheres thereto, it has a strength that will not bend or break. The base material 10 is formed of an insulating material. As the insulating material, plastic, glass epoxy resin, ceramic, glass, etc. can be used. As the base material 10, for example, a rigid substrate or a flexible substrate can be used.

[0018] The size of the base material 10 is not particularly limited, but its length can be, for example, 20 mm or more and 115 mm or less. Also, its width can be, for example, 6 mm or more and 30 mm or less.

[0019] On the main surface of the base material 10, a first cell 20 for storing a test solution is provided on one end side thereof. The first cell 20 is made of a material having water resistance and insulation properties such as plastic, for example, and is configured in a hollow cylindrical shape with a rectangular cross-section in a cross-sectional view. The internal space of the first cell 20 becomes a space for storing the test solution. The first cell 20 is provided with an inlet 21. This inlet 21 has a size sufficient for taking in the test solution, and when the test solution is poured over the first cell 20, it becomes an opening for taking in the test solution into the internal space.

[0020] On the main surface of the base material 10, a second cell 30 is provided at a distance from the first cell 20. The second cell 30 contains the sensor electrode 40. The second cell 30 is configured such that the inflow of the test solution is suppressed in a state where it is detached from the measuring instrument 200, while the test solution flows in when it is attached to the measuring instrument 200. The internal space of the second cell 30 stores the test solution flowing in from the first cell 20 and becomes a space for causing an electrochemical reaction by the contact between the sensor electrode 40 and the test solution. The second cell 30 is made of a material having water resistance and insulation properties such as plastic, for example, like the first cell 20, and is configured in a hollow cylindrical shape with a rectangular cross-section in a cross-sectional view so as to be able to contain the sensor electrode 40.

[0021] From the perspective of more reliably bringing the test liquid into contact with the sensor electrode 40 within the second cell 30, it is preferable that the volume of the second cell 30 is smaller than the volume of the first cell 20.

[0022] A flow path 50 for communicating the spaces within them is provided between the first cell 20 and the second cell 30. The flow path 50 is configured to allow the test liquid to flow from the first cell 20 into the second cell 30 by a trigger structure. The flow path 50 is not particularly limited as long as it can allow the test liquid to flow, and for example, a plastic tube or the like can be used. As shown in Fig. 3(a), the opening on the first cell 20 side of the flow path 50 is arranged to be immersed in the test liquid S stored in the first cell 20.

[0023] From the perspective of allowing the test liquid S to flow into the second cell 30 by capillary action, it is preferable that the flow path 50 has a shape that causes capillary action. For example, the inner diameter of the flow path 50 is preferably such that capillary action occurs, specifically, it is preferably 1 mm or more and 10 mm or less. Also, the length of the flow path 50 is preferably such that the test liquid can be drawn from the first cell 20 into the second cell 30 by capillary action, specifically, it is preferably 3 mm or more and 20 mm or less.

[0024] The sensor electrode 40 causes an electrochemical reaction upon contact with the test solution S and is encapsulated within the second cell 30. As the sensor electrode 40, for example, a working electrode, a counter electrode, and a reference electrode can be used. The material of the working electrode can be appropriately selected according to the type of specific component to be measured. As the working electrode, for example, an electrode formed of a metal such as silver (Ag), Au, platinum (Pt), or Cu, a carbon electrode, or a conductive diamond electrode doped with boron (B) can be used. A functional membrane containing an enzyme or an antibody that promotes an electrochemical reaction may be fixed to the surface of the working electrode. The counter electrode is not particularly limited as long as it is a conductive electrode, and the same material as that of the working electrode can be used. As the reference electrode, for example, a silver / silver chloride (Ag / AgCl) electrode or the like can be used. Note that the sensor electrode 40 is not limited to the three-electrode type shown in Fig. 2(a), and may be a two-electrode type. For example, it may be configured to include a working electrode and a counter electrode that also serves as a reference electrode.

[0025] A wiring 41 is connected to the sensor electrode 40. The wiring 41 is arranged to be connected to a connection terminal 42 provided on the side opposite to the first cell 20 of the sensor unit 100. The sensor unit 100 can be electrically connected by inserting the side of the connection terminal 42 into, for example, the insertion port of the measuring instrument 200.

[0026] The wiring 41 can be formed using a metal such as copper (Cu) or aluminum (Al). For example, the wiring 41 can be formed using a subtractive method in which unnecessary portions of a copper film pre-pasted on the substrate 10 and not covered with a resist are removed by etching to form a necessary conductor pattern. Further, these conductor patterns formed using the subtractive method may be subjected to, for example, gold (Au) plating or silver (Ag) plating. Also, for example, the wiring 41 can be formed by screen printing. In this case, a silver or carbon-based wiring can be formed.

[0027] (Measuring instrument) The measuring instrument 200 is configured to be connectable to the sensor unit 100 and is configured to measure an electrochemical reaction that occurs when the sensor electrode 40 comes into contact with the test solution S. For example, the measuring instrument 200 is configured to perform a predetermined voltage sweep scan or the like on the sensor electrode 40 to electrolyze a specific component contained in the test solution, and to measure the concentration or the like of the specific component from the magnitude of the reaction that occurs at that time. Also, for example, the measuring instrument 200 is configured to measure the concentration or the like of a specific component from the amount of change in voltage (electromotive force) or the amount of change in current generated by an electrochemical reaction on the surface of the sensor electrode 40. In the present embodiment, as shown in FIG. 3(b), the measuring instrument 200 has an insertion port for the sensor unit 100 and includes a needle-like member 210 at a position where the vent tube 60 is broken when the sensor unit 100 is inserted.

[0028] Preferably, the measuring instrument 200 is preferably configured to start the electrochemical measurement triggered by the attachment of the sensor unit to the measuring instrument. Thereby, at the stage when the test solution S starts to flow from the first cell 20 to the second cell 30, the electrochemical reaction caused by the contact between the test solution S and the sensor electrode 40 can be quickly measured. As a result, fluctuations in sensor sensitivity can be avoided and the reproducibility of the measurement results can be improved.

[0029] Also preferably, the measuring instrument 200 is preferably configured to start the electrochemical measurement after a predetermined time has elapsed after the sensor unit 100 is attached to the measuring instrument 200. After the sensor unit 100 is attached, the test solution S starts to flow into the second cell 30, and after a predetermined time has elapsed, the second cell 30 is filled with a predetermined amount of the test solution S, and the flow of the test solution S becomes a steady state. By performing the electrochemical measurement in this state, the reproducibility of the measurement results can be further improved.

[0030] In addition, the measuring instrument 200 is configured to be able to transmit data indicating the concentration of the specific component obtained by the above-described measurement to the determination support device 300 through wireless communication means, wired communication means, or the like.

[0031] (Determination Support Device) The determination support device 300 is configured as a computer (such as a smartphone, tablet, PC, etc.) equipped with a CPU, RAM, storage, output function, and communication function. The determination support device 300 is configured to be able to output determination result data indicating the health status of the subject, etc., to the subject or other information processing devices based on the concentration data received at a predetermined timing.

[0032] (2) Measurement Method Next, the measurement method in the above-mentioned measurement system 1 will be described with reference to FIG. 12. FIG. 12 is a schematic diagram showing a measurement system for a test liquid in a toilet. In FIG. 12, the case where the measuring device 200 and the determination support device 300 are installed on the wall 400a of the toilet 400 is illustrated as an example.

[0033] First, the subject prepares the sensor unit 100. For example, the subject brings the sensor unit 100 into the toilet 400 or picks up the sensor unit 100 installed in the toilet 400. Subsequently, the subject holds the connection terminal 42 side of the sensor unit 100 as shown in FIGS. 2(a) and 2(b) at the toilet bowl 410 and pours the test liquid S (such as urine) toward the first cell 20. As a result, as shown in FIG. 3(a), the test liquid S flows into the first cell 20 from the inlet 21. At this stage, the vent tube 60 is not opened and the inside of the second cell 30 is in an airtight state. Therefore, the test liquid S does not flow into the second cell 30 and stays in the first cell 20. The subject pours the test liquid S until a predetermined amount of the test liquid S is stored in the first cell 20.

[0034] Subsequently, after a predetermined amount of the test liquid S is stored in the first cell 20, the subject inserts the sensor unit 100 with its connection terminal 42 side into the insertion port of the measuring instrument 200 and attaches it to the measuring instrument 200. At this time, as shown in FIG. 3(b), due to the structural interference between the sensor unit 100 and the needle-like member 210 of the measuring instrument 200, one end of the vent tube 60 is torn and opened. As a result, the airtight state of the vent tube 60 is released, and the atmosphere in the second cell 30 can escape to the outside. As a result, the test liquid S stored in the first cell 20 flows into the second cell 30 through the flow path 50 due to capillary action. In the second cell 30, the test liquid S comes into contact with the sensor electrode 40, and an electrochemical reaction occurs.

[0035] On the other hand, in the measuring instrument 200, by performing a predetermined voltage sweep scan or the like on the sensor electrode 40, a specific component contained in the test liquid S is electrolyzed or the like, and the concentration or the like of the specific component is measured from the magnitude of the reaction that occurs at that time.

[0036] In the determination support device 300, determination result data or the like indicating the health state of the subject is output based on the measurement data obtained by the measuring instrument 200.

[0037] As described above, the subject can obtain the measurement result using the sensor unit 100 in the toilet 400.

[0038] (3) Effects according to this embodiment According to this embodiment, one or more of the following effects are achieved.

[0039] (a) The sensor unit 100 of this embodiment is configured separately from the measuring instrument 200. Before being attached to the measuring instrument 200, when the test liquid S is poured over, the test liquid S is allowed to flow into and be stored in the first cell 20, but the test liquid S is not allowed to flow into the second cell 30 that houses the sensor electrode 40. Thereby, the contact between the collected test liquid S and the sensor electrode 40 can be temporarily suppressed. Therefore, even if time has passed from when the test liquid S is collected until it is used for measurement, it is possible to suppress the sensor sensitivity from fluctuating due to the components contained in the test liquid S adhering to the sensor electrode 40. Further, the sensor unit 100 includes a flow path 50 that connects the first cell 20 and the second cell 30, and a vent tube 60 that is connected to the second cell 30 and is for allowing the atmosphere inside the second cell 30 to escape to the outside. The vent tube 60 is configured to be opened by the structural interference between the components of the sensor unit 100 and the components of the measuring instrument 200 when the sensor unit 100 is attached to the measuring instrument 200. Specifically, when the sensor unit 100 is attached to the measuring instrument 200, the end of the vent tube 60, which is a component of the sensor unit 100, is broken by a needle-like member 210, which is a component of the measuring instrument 200, and thus the vent tube 60 is opened. With the opening of this vent tube 60, the test liquid S stored in the first cell 20 can be caused to flow into the second cell 30 through the flow path 50 by capillary action. That is, the supply of the test liquid S into the second cell 30 can be performed with the attachment to the measuring instrument 200 as a trigger. As a result, it becomes possible to bring the test liquid S into contact with the sensor electrode 40 in the second cell 30 and cause an electrochemical reaction to occur. Also, when the sensor unit 100 is attached to the measuring instrument 200, a specific component contained in the test liquid S can be measured by performing a predetermined voltage sweep scan or the like on the sensor electrode 40 by the measuring instrument 200. Thus, according to the sensor unit 100 of the present embodiment, while suppressing the contact between the test liquid S and the sensor electrode 40 from the time the test liquid S is collected until it is used for measurement, by causing the contact between the test liquid S and the sensor electrode 40 with the attachment to the measuring instrument 200 as a trigger, measurement with high sensor sensitivity can be realized. Moreover, since variations in measurement accuracy can be reduced, the reproducibility of measurement results can be maintained at a high level.

[0040] (b) According to the measurement system 1 of the present embodiment, for example, the measuring instrument 200 can be installed inside the wall 400a of the toilet 400, and the subject can perform measurement using the sensor unit 100. That is, measurement can be performed easily, and high convenience can be realized. Also, for one measuring instrument 200, a plurality of subjects can each wear the sensor unit 100, making it possible to share the measuring instrument 200. Therefore, the system cost can be reduced.

[0041] (c) In the sensor unit 100, the flow path 50 preferably has a shape in which capillary action occurs. Thereby, the test liquid S stored in the first cell 20 can be more reliably caused to flow into the second cell 30.

[0042] (d) In the sensor unit 100, the volume of the second cell 30 is preferably smaller than the volume of the first cell 20. Thereby, even when the amount of the test liquid S supplied from the second cell 30 to the first cell 20 is small, the test liquid S and the sensor electrode 40 can be more reliably brought into contact within the second cell 30.

[0043] (e) In the measurement system 1, the measuring instrument 200 is preferably configured to start electrochemical measurement with the attachment of the sensor unit 100 to the measuring instrument 200 as a trigger. Thereby, simultaneously with supplying the test liquid S to the second cell 30, the test liquid S can be brought into contact with the sensor electrode 40 to perform electrochemical measurement. As a result, fluctuations in sensor sensitivity can be avoided, and the reproducibility of measurement results can be improved.

[0044] (f) In the measurement system 1, it is preferable that the measuring instrument 200 is configured to start the electrochemical measurement after a predetermined time has elapsed after the sensor unit 100 is attached to the measuring instrument 200. Thereby, the flow of the test solution S in the second cell 30 can be made steady state and the measurement can be performed. As a result, the reproducibility of the measurement results can be further improved.

[0045] <Other embodiments> As described above, the embodiments of the present invention have been described. However, the present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the gist of the present invention.

[0046] In the above-described embodiment, the case where the subject collects the test solution S in the sensor unit 100 and immediately attaches it to the measuring instrument 200 has been described. However, the present invention is not limited to this. According to the sensor unit 100, since the contact between the test solution S and the sensor electrode 40 can be suppressed until it is attached to the measuring instrument 200, the test solution S may be collected, and after a predetermined time has elapsed, it may be attached to the measuring instrument 200 for measurement. For example, after collecting the test solutions of a plurality of subjects, each sensor unit 100 may be attached to the measuring instrument 200 for measurement after a certain time has elapsed.

[0047] In the above-described embodiment, the supply of the test solution S through the flow path 50 from the first cell 20 into the second cell 30 has been described by taking the case where the vent tube 60 is opened due to the structural interference between the components when the sensor unit 100 is attached to the measuring instrument 200 as an example. However, the present invention is not limited to this. Hereinafter, modified examples of the trigger structure due to structural interference will be described.

[0048] In the above-described embodiment, the case where the vent tube 60 is broken and opened by the needle-like member 210 has been described. However, the opening of the vent tube 60 is not limited to this. For example, the vent tube 60 may be provided with a valve (not shown) that can be opened and closed at the end on the measuring instrument 200 side, and when the sensor unit 100 is inserted into the insertion port of the measuring instrument 200, the valve may be configured to be opened by these structural interferences. By opening the valve, the atmosphere in the second cell 30 can be released to the outside. In this way, when the sensor unit 100 is attached to the measuring instrument 200, the test liquid S flows into the second cell 30 triggered by the opening of the valve. Note that the valve may be configured to be opened and closed physically or electrically when the sensor unit 100 is attached to the measuring instrument 200, and is not particularly limited.

[0049] Also, for example, as shown in FIG. 4(a), in the sensor unit 100, a notch region 62 may be formed in a region (the broken-line region in the figure) including one end of the vent tube 60. In this case, as shown in FIG. 4(b), when the sensor unit 100 is inserted into the insertion port of the measuring instrument 200, the notch region 62 is removed by the sensor unit 100 due to structural interference. As a result, the end of the vent tube 60 is removed. Thereby, the vent tube 60 is opened, and the atmosphere in the second cell 30 can be released to the outside. As a result, the test liquid S can be made to flow into the second cell 30 from the first cell 20 through the flow path 50. In this way, when the sensor unit 100 is attached to the measuring instrument 200, the test liquid S flows into the second cell 30 triggered by the removal of the notch region 62.

[0050] For example, the supply of the test liquid S from the first cell 20 to the second cell 30 may be configured to be started by forming the flow path 50 by structural interference instead of opening the vent tube 60. Specifically, as shown in FIG. 5(a), a blocked portion 51 (the broken line region in the figure) is provided in a part of the flow path 50 that connects the first cell 20 and the second cell 30. The blocked portion 51 can be provided, for example, by forming the flow path 50 with a flexible member and applying bending or folding to a part of its flow direction. The test liquid S taken into the first cell 20 will not flow into the second cell 30 due to the blocked portion 51 and will stay. In this case, as shown in FIG. 5(b), when the sensor unit 100 is attached to the measuring instrument 200, the flow path 50 may be deformed to be straight by the structural interference between the measuring instrument 200 and the sensor unit 100 to open the flow path 50. As a result, the test liquid S will flow from the first cell 20 to the second cell 30 through the flow path 50, for example, by capillary action. In FIG. 5(a), the second cell 30 is provided with a hole (not shown) for discharging the air in the atmosphere to the outside, and when the test liquid flows into the second cell 30, the atmosphere in the second cell 30 is configured to escape to the outside.

[0051] Alternatively, instead of providing the blocked portion 51 in the flow path 50, a plug (not shown) that physically blocks the flow path 50 may be provided. The flow path 50 may be configured to be opened by opening, closing, or destroying the plug by structural interference. The plug can be formed from resin, plastic, or the like. With these plugs, for example, when the sensor unit 100 is inserted into the measuring instrument 200, heat, vibration, or impact can be applied to the flow path 50 to break the plug and open the flow path 50. Also, the plug may be formed of a magnetic material, for example, and in this case, the opening and closing of the plug can be performed magnetically as the structural interference.

[0052] Also, for example, as shown in FIG. 6(a), the first cell 20 may be configured to be compressible by structural interference. The first cell 20 can be formed of, for example, a flexible member (such as resin or plastic). Further, the first cell 20 is preferably configured such that when it is compressed while taking in the test liquid S from the intake port, the test liquid S does not flow out from the intake port. For example, a check valve may be provided at the intake port of the first cell 20. On the other hand, the second cell 30 is preferably provided with a hole (not shown) for discharging the air in the atmosphere to the outside. The flow path 50 preferably has a thickness such that it does not suck up the test liquid S by capillary action. In this case, although the test liquid S is taken into the first cell 20, it will stay in the first cell 20 without flowing into the second cell 30. Then, as shown in FIG. 6(b), by compressing the first cell 20, the test liquid S is pumped into the second cell 30 through the flow path 50. Here, the supply of the test liquid S to the second cell 30 can be performed by using the compression of the first cell 20 when the sensor unit 100 is attached to the measuring instrument 200 as a trigger.

[0053] Also, for example, as shown in FIG. 7(a), the second cell 30 may be configured to be expandable by structural interference. The second cell 30 is preferably formed of, for example, a flexible member (such as resin or plastic). Further, the second cell 30 is preferably configured such that its interior is airtight. In this case, although the test liquid S is taken into the first cell 20, since the second cell 30 is in an airtight state, the test liquid S will stay in the first cell 20 without flowing into the second cell 30. Then, as shown in FIG. 7(b), the second cell 30 is expanded by structural interference, and the test liquid S is sucked from the first cell 20 into the second cell 30 through the flow path 50 due to the negative pressure generated in the second cell 30. Here, the supply of the test liquid S to the second cell 30 can be performed by using the expansion of the second cell 30 by structural interference as a trigger.

[0054] In the above-described embodiment, as an example of a trigger for causing the test liquid S to flow from the first cell 20 to the second cell 30, the structural interference caused by attaching the sensor unit 100 to the measuring instrument 200 has been described. However, the present invention is not limited to this. The trigger is not limited to the attachment of the sensor unit 100 to the measuring instrument 200. Structural interference may be applied to the components of the sensor unit 100 by an external operation such as manual operation or a jig, and the test liquid may be supplied from the first cell 20 to the second cell 30. For example, with respect to the sensor unit 100 storing the test liquid S, by externally operating to break the end of the vent tube 60 or removing the notch region 62, after causing the test liquid S to flow into the second cell 30, the sensor unit 100 may be attached to the measuring instrument 200. Also, as a trigger, for example, non-contact structural interference may be performed by a magnet or the like to supply the test liquid to the second cell 30. For example, after causing the test liquid S to flow into the second cell 30 by opening a valve or removing a stopper with a magnet or the like, the sensor unit 100 may be attached to the measuring instrument 200.

[0055] Further, in the above-described embodiment, the case where the sensor unit 100 includes the flow path 50 has been described. However, the present invention is not limited to this. For example, as shown in FIG. 8, the first cell 20 and the second cell 30 may be configured such that their respective spaces are partitioned by a partition wall 52. In this case, when the sensor unit 100 is attached to the measuring instrument 200, it is preferable to break the partition wall 52. The crack in the partition wall 52 can supply the test liquid S from the first cell 20 to the second cell 30 as a flow path.

[0056] In the above-described embodiment, the case of measuring an electrochemical reaction generated by contact with the test liquid S using the sensor electrode 40 has been described as an example. However, the present invention is not limited to this. For example, an inspection sheet that changes color by reacting with a specific component contained in the test liquid S may be used in combination with the sensor electrode 40. In this case, for example, as shown in FIG. 9, the inspection sheet 70 may be included in the second cell 30 together with the sensor electrode 40.

[0057] The test sheet 70 is configured such that its working surface changes color upon contact with the test solution S. According to the test sheet 70, it is possible to measure components in a format different from that of the sensor electrode 40. Therefore, by using the sensor electrode 40 and the test sheet 70 in combination, it becomes possible to measure, for example, components that are difficult to measure with the sensor electrode 40 using the test sheet 70. That is, it becomes possible to simultaneously measure a plurality of components contained in the test solution S. The test sheet 70 is not particularly limited as long as it exhibits a color change upon contact with a specific component, and a conventionally known one can be used.

[0058] When using the test sheet 70, the same problems as those of the sensor electrode 40 may occur. When the test solution S is left in contact with the test sheet 70, specific components (such as proteins) in the test solution S may deposit on the working surface, which may change the degree of color change. Also, the amount of change in this degree may vary greatly depending on the contact time and environmental conditions. In this regard, by adopting the form shown in FIG. 9, the supply of the test solution S to the test sheet 70 can be adjusted to the same timing as the supply to the sensor electrode 40. As a result, the reproducibility of the measurement results can be further improved.

[0059] Also, when providing the test sheet 70, it is preferable that the measuring device 200 further includes photographing means for photographing the working surface of the test sheet 70, and is configured such that the photographing of the test sheet 70 is triggered by the attachment of the measuring device 200 to the sensor unit 100. Thereby, it is possible to measure the color change of the test sheet 70 together with the measurement of the electrochemical reaction at the sensor electrode 40. Alternatively, it is preferable that the measuring device 200 is configured to start photographing the test sheet 70 after a predetermined time has elapsed after the measuring device 200 of the sensor unit 100 is attached. Thereby, it is possible to photograph the color change of the test sheet 70 after the inflow of the test solution S into the second cell 30 is completed and the inside of the second cell 30 has reached a steady state. As a result, the reproducibility of the measurement results can be further improved. Note that the measuring means and the photographing means for performing the electrochemical measurement may be configured as the same device or as separate devices.

[0060] Also, in FIG. 9, an odor sensor may be used instead of the inspection sheet 70, or the sensor electrode 40, the inspection sheet 70, and the odor sensor may be used in combination. Since the odor also changes over time, the same problems as those of the sensor electrode 40 may occur. However, by incorporating it into the second cell 30, the above problems can be solved.

[0061] Also, FIG. 9 shows a case where the sensor electrode 40 and the inspection sheet 70 are used in combination, but only the inspection sheet 70 can be arranged. As described above, even in the case of the inspection sheet 70, variations in measurement accuracy may occur due to the passage of time caused by contact with the test liquid S. In this regard, by adopting the configuration of the above-described embodiment, variations in measurement accuracy with the inspection sheet 70 can be reduced, and the reproducibility of the measurement results can be maintained at a high level. As the measuring instrument 200, it is preferable to use one equipped with photographing means for photographing the working surface of the inspection sheet 70.

[0062] Also, for example, as shown in FIG. 10, a third cell 80 for temporarily storing the test liquid S may be provided on the flow path 50 provided between the first cell 20 and the second cell 30. The third cell 80 can function as a flow rate adjusting unit that adjusts the time until the test liquid S flows from the first cell 20 into the second cell 30, or as a reaction unit that encapsulates a predetermined reagent and reacts the test liquid S. When functioning as a reaction unit, the third cell 80 may encapsulate, for example, a reagent 81 that reacts with the components contained in the test liquid S. Depending on the components contained in the test liquid S, it may be difficult to directly measure the electrochemical reaction. In this regard, it becomes possible to supply the test liquid S from the first cell 20 to the second cell 30 via the third cell 80 that encapsulates a reagent or the like. Thereby, after reacting the test liquid S, it can be used for electrochemical measurement.

[0063] In the above-described embodiment, the case of one second cell 30 has been described, but the present invention is not limited thereto. For example, as shown in FIG. 11, each of a plurality of second cells 30 may be configured to communicate with one first cell 20 via a flow path 50. In this case, a vent tube 60 may be connected to each second cell 30 so that the vent tube 60 is opened due to structural interference. According to such a configuration, by changing the measurement conditions at the sensor electrodes 40 included in the plurality of second cells 30, a plurality of components contained in the test liquid S can be measured in parallel. Note that FIG. 11 shows a case where sensor electrodes 40 are provided in each of three second cells 30 corresponding to three connection terminals 42, and an inspection sheet 70 is included in one second cell 30. Further, the arrangement of the plurality of second cells 30 is not particularly limited. For example, the first cell 20 may be arranged at the center, and a plurality of second cells 30 may be arranged radially around it. Also, FIG. 11 shows the case where the number of second cells 30 is four, but the number is not particularly limited. Further, FIG. 11 shows the case where the test liquid S flows in with the opening of the vent tube 60 as a trigger, but the compression of the first cell 20 or the expansion of the second cell 30 described above may also be used as a trigger.

[0064] Further, when a plurality of second cells 30 are provided, the lengths of the flow paths 50 connected to each of them may be the same or different. When the lengths of the flow paths 50 are the same, the timing at which the test liquid S flows into each second cell 30 can be made the same. On the other hand, when the lengths of the flow paths 50 are configured to be different, the time until the test liquid S flows into each second cell 30 can be intentionally shifted.

[0065] Also, when providing a plurality of second cells 30, among the plurality of flow paths 50, a third cell may be provided between the first cell 20 and the second cell 30 in at least one of them. Thereby, regarding the time for the test liquid S to flow into the second cell 30, the system passing through the third cell can be adjusted to be relatively long, and the system not passing through it can be adjusted to be relatively short. Or, in the system passing through the third cell, after reacting the test liquid S with the reagent contained in the third cell, it is made to flow into the second cell 30, while in the system not passing through the third cell, the test liquid S can be made to flow into the second cell 30 as it is.

[0066] Also, in FIG. 9, the case where the sensor electrode 40 and the inspection sheet 70 are contained in one second cell 30 has been described. However, when providing a plurality of second cells 30, the sensor electrode 40 and the inspection sheet 70 may be respectively contained in separate second cells 30. When the sensor electrode 40 and the inspection sheet 70 exist in the same space, it may interfere with each measurement, but by separating them into separate second cells 30, such interference can be reduced.

[0067] Also, in the above-described embodiment, the case where the test liquid S is poured onto the sensor unit 100 before attaching the sensor unit 100 to the measuring instrument 200 has been described. However, the present invention is not limited to this. The sensor unit 100 may pour the test liquid S onto the first cell 20 while being attached to the measuring instrument 200. In this case, simultaneously with the test liquid S being stored in the first cell 20, the test liquid S flows into the second cell 30 through the flow path 50. That is, the sensor unit 100 can automatically make the test liquid S flow into the second cell 30 while being attached to the measuring instrument 200.

[0068] In the above-described embodiment, the case where the first cell 20 includes an inlet 21, takes in the test liquid S from the inlet 21, and stores the test liquid S in its internal space has been described. However, the present invention is not limited to this. For example, instead of the inlet 21, the first cell 20 may be configured such that a tube capable of taking in the test liquid S from the outside by, for example, capillary action is connected thereto. Further, for example, the first cell 20 may be formed of a moisture-absorbable member and configured to retain and store the flowing test liquid S.

[0069] In the above-described embodiment, the case where the measurement system 1 includes the sensor unit 100, the measuring instrument 200, and the determination support device 300 has been described. However, the determination support device 300 may be provided as necessary and can also be omitted.

[0070] Also, as a preferred form, there is provided a measurement system for measuring a subject's urine, the measurement system being portable, detachable from a measuring instrument for performing electrochemical measurement, and including a sensor unit configured to be able to store urine when the subject's urine is poured over it, a measuring instrument installed on the inner wall of a toilet, connectable to the sensor unit and configured to perform electrochemical measurement, and a determination support device configured to be able to output a measurement result obtained by the measuring instrument.

[0071] According to such a measurement system, since the measuring instrument is installed inside the toilet wall while the sensor unit can be carried by the subject, the subject can collect urine in the toilet and supply the urine to the measuring instrument with a simple operation. Further, since a plurality of subjects can each perform urine measurement with one measuring instrument, the system cost can be reduced. Also, according to the determination support device, for example, after registering the individual ID of the subject, the measurement result and the ID can be associated, and even when a plurality of subjects use it, the measurement result of a specific subject can be output.

[0072] <Preferred Embodiment of the Present Disclosure> Hereinafter, preferred embodiments of the present disclosure will be appended.

[0073] (Appendix 1) A sensor unit configured to be detachable from a measuring instrument for performing electrochemical measurements, a first cell for temporarily storing a test solution supplied from the outside, and a second cell containing a sensor electrode, and the supply of the test solution from the inside of the first cell to the inside of the second cell is configured to be performed triggered by the attachment of the sensor unit to the measuring instrument. A sensor unit.

[0074] (Appendix 2) When the test solution is supplied to the sensor unit with the sensor unit detached from the measuring instrument, the test solution is configured to stay in the first cell without flowing into the second cell. The sensor unit according to Appendix 1.

[0075] (Appendix 3) The structural interference between the components of the measuring instrument and the components of the sensor unit when the sensor unit is attached to the measuring instrument is configured to function as the trigger. The sensor unit according to Appendix 1 or Appendix 2.

[0076] (Appendix 4) It is provided in the second cell and includes a vent tube for allowing the atmosphere in the second cell to escape to the outside. The vent tube is opened by the structural interference of the components when the sensor unit is attached to the measuring instrument, and the inflow of the test solution into the second cell is configured to be started. The sensor unit according to Appendix 3.

[0077] (Appendix 5) A flow path that communicates the inside of the first cell and the inside of the second cell is formed by the structural interference of the components when the sensor unit is attached to the measuring instrument, and the inflow of the test solution into the second cell is configured to be started through the flow path. The sensor unit described in Supplementary Note 3.

[0078] (Supplementary Note 6) The first cell and the second cell are separated by a partition wall and configured, When the sensor unit is attached to the measuring instrument, the partition wall is broken due to structural interference of the components, and a crack formed in the partition wall becomes the flow path. The sensor unit described in Supplementary Note 5.

[0079] (Supplementary Note 7) When the sensor unit is attached to the measuring instrument, the first cell is compressed due to structural interference of the components, and the pumping of the test liquid into the second cell is started. The sensor unit described in Supplementary Note 3.

[0080] (Supplementary Note 8) When the sensor unit is attached to the measuring instrument, the second cell is expanded due to structural interference of the components, and the suction of the test liquid into the second cell is started due to the negative pressure generated in the second cell. The sensor unit described in Supplementary Note 3.

[0081] (Supplementary Note 9) It is provided with a flow path that communicates the inside of the first cell and the inside of the second cell. The flow path has a shape that exhibits capillary action when taking in the test liquid from the inside of the first cell into the second cell. The sensor unit according to any one of Supplementary Notes 4 to 8.

[0082] (Supplementary Note 10) When the test liquid is supplied to the sensor unit while attached to the measuring instrument, It is configured such that the test liquid flows from the first cell into the second cell. The sensor unit according to any one of Supplementary Notes 1 to 9.

[0083] (Supplementary Note 11) The volume of the second cell is smaller than the volume of the first cell, The sensor unit according to any one of Appendices 1 to 10.

[0084] (Appendix 12) A flow path that connects the inside of the first cell and the inside of the second cell, On the flow path, a third cell for temporarily storing the test liquid is provided, The inflow of the test liquid into the second cell is configured to pass through the third cell via the flow path. The sensor unit according to Appendices 4 to 7.

[0085] (Appendix 13) The third cell contains a reaction reagent capable of reacting with a specific component in the test liquid. The sensor unit according to Appendix 14.

[0086] (Appendix 14) A plurality of second cells with respect to one first cell, A vent tube provided in each of the plurality of second cells for releasing the atmosphere inside each second cell to the outside, When the sensor unit is attached to the measuring instrument, the vent tube is opened due to the structural interference of the components, and the inflow of the test liquid into the plurality of second cells is started. The sensor unit according to Appendix 3.

[0087] (Appendix 15) A plurality of flow paths that connect the inside of the first cell and each of the plurality of second cells, The plurality of flow paths are configured such that their respective lengths are the same or different. The sensor unit according to Appendix 14.

[0088] (Appendix 16) At least one of the plurality of flow paths includes a third cell for temporarily storing the test liquid. The inflow of the test liquid from the first cell into the second cell is configured to be performed via the third cell through the flow path. The sensor unit according to Supplementary Note 15.

[0089] (Supplementary Note 17) In the second cell, an inspection sheet configured to change the color of the working surface upon contact with the test liquid is disposed. The sensor unit according to any one of Supplementary Notes 1 to 16.

[0090] (Supplementary Note 18) A measuring instrument configured to be connectable to the sensor unit according to any one of Supplementary Notes 1 to 17 and including measuring means for performing electrochemical measurement, The measuring instrument is configured such that the start of the electrochemical measurement is triggered by the attachment of the sensor unit to the measuring instrument.

[0091] (Supplementary Note 19) A measuring instrument configured to be connectable to the sensor unit according to any one of Supplementary Notes 1 to 17 and including measuring means for performing electrochemical measurement, The measuring instrument is configured such that the start of the electrochemical measurement is performed after a lapse of a predetermined time after the attachment of the sensor unit to the measuring instrument.

[0092] (Supplementary Note 20) A measuring instrument configured to be connectable to the sensor unit according to Supplementary Note 17 and including imaging means for imaging the working surface of the inspection sheet, The measuring instrument is configured such that the imaging of the inspection sheet is triggered by the attachment of the sensor unit to the measuring instrument.

[0093] (Supplementary Note 21) A measuring instrument configured to be connectable to the sensor unit according to Supplementary Note 17 and including imaging means for imaging the working surface of the inspection sheet, The measuring instrument is configured to take a photograph of the inspection sheet after a predetermined period of time has elapsed after the sensor unit is attached to the measuring instrument.

[0094] (Appendix 22) The test solution is urine, The measuring instrument is installed inside the toilet, The measuring instrument according to any one of Appendices 18 to 21.

[0095] (Appendix 23) A sensor unit configured to be detachable from the measuring instrument, A first cell for temporarily storing the test solution supplied from the outside, A second cell containing an inspection sheet configured to change color on the working surface when it comes into contact with the test solution, and comprising: The sensor unit is configured such that the supply of the test solution from the inside of the first cell to the inside of the second cell is triggered by attaching the sensor unit to the measuring instrument.

[0096] (Appendix 24) A measurement system for measuring the urine of a subject, A sensor unit having portability, detachable from a measuring instrument for performing electrochemical measurement, and configured to be able to store urine when the urine of the subject is poured over it, A measuring instrument connectable to the sensor unit and configured to perform electrochemical measurement, and comprising: The measuring instrument is installed on the inner wall of the toilet, Urine measurement system.

[0097] (Appendix 25) The sensor unit is, A first cell for temporarily storing the urine of the subject, A second cell containing a sensor electrode, and comprising: The supply of the test solution from the inside of the first cell to the inside of the second cell is configured to be triggered by attaching the sensor unit to the measuring instrument, The measuring device is configured to start the electrochemical measurement triggered by the attachment of the sensor unit to the measuring device. The urine measurement system according to Supplementary Note 24.

Explanation of symbols

[0098] 1 Measurement system 100 Sensor unit 200 Measuring device 300 Judgment support device 400 Toilet 10 Base material 20 First cell 21 Inlet 30 Second cell 40 Sensor electrode 41 Wiring 42 Connection terminal 50 Flow path 51 Blocked portion 60 Vent pipe 61 Valve 62 Notch region 70 Inspection sheet 80 Third cell 81 Reagent S Test solution

Claims

1. A sensor unit configured to be detachable from a measuring device configured to measure discoloration of a subject, a first cell for temporarily storing a test liquid supplied from an external source; a second cell configured such that when the second cell comes into contact with the test liquid, the working surface thereof changes color due to a component contained in the test liquid, and the second cell contains a test sheet to be measured by the measuring device; The sensor unit is configured so that the supply of the sample liquid from the first cell to the second cell is triggered by mounting the sensor unit on the measuring device.

2. When the test liquid is supplied to the sensor unit in a state where the sensor unit is detached from the measurement device, the test liquid is configured to remain in the first cell without flowing into the second cell. The sensor unit according to claim 1 .

3. A configuration is provided in which structural interference between components of the measuring device and components of the sensor unit when the sensor unit is attached to the measuring device functions as the trigger. The sensor unit according to claim 1 .

4. a vent pipe provided in the second cell for releasing an atmosphere in the second cell to the outside; a vent pipe is opened by structural interference between the components when the sensor unit is attached to the measuring device, and the test liquid starts to flow into the second cell. The sensor unit according to claim 3 .

5. the vent pipe is configured so that a part of the vent pipe breaks and opens due to structural interference with the measuring instrument when the sensor unit is attached to the measuring instrument. The sensor unit according to claim 4.

6. A cutout area is configured to be capable of cutting out an area including a portion of the vent pipe, the vent pipe is configured such that, when the sensor unit is attached to the measuring instrument, structural interference with the measuring instrument causes the cutout region to be removed and the portion to be opened. The sensor unit according to claim 4.

7. a flow path that communicates between the first cell and the second cell is formed by structural interference between the components when the sensor unit is attached to the measuring device, and a test liquid is configured to start flowing into the second cell through the flow path. The sensor unit according to claim 3 .

8. a first cell is compressed by structural interference between the components when the sensor unit is attached to the measuring device, and pressure-feeding of the test liquid into the second cell is started. The sensor unit according to claim 3 .

9. The second cell is expanded by structural interference of the components when the sensor unit is attached to the measuring device, and the negative pressure generated in the second cell starts suction of the test liquid into the second cell. The sensor unit according to claim 3 .

10. a flow path that communicates between the first cell and the second cell, the flow path has a shape that causes capillary action when the test liquid is introduced from the first cell into the second cell; The sensor unit according to claim 4.

11. a flow path that communicates the first cell with the second cell; a third cell for temporarily storing the test liquid on the flow path; The test liquid is configured to flow from the first cell into the second cell via the third cell. The sensor unit according to claim 3 .

12. A plurality of second cells for one first cell; a vent pipe provided in each of the second cells for releasing an atmosphere in each of the second cells to the outside; a vent pipe is opened by structural interference between the components when the sensor unit is attached to the measuring device, and the test liquid starts to flow into the second cells. The sensor unit according to claim 3 .

13. a plurality of flow paths that communicate between the first cell and each of the plurality of second cells; The multiple flow paths are configured to have the same or different lengths. The sensor unit according to claim 12.

14. A substrate made of an insulating material is provided, the first cell and the second cell are provided on the substrate, The first cell has an inlet for taking in the test liquid, and is configured to take in the test liquid from the inlet and store the test liquid when the test liquid is poured. The sensor unit according to claim 1 .

15. When the test liquid is supplied to the sensor unit while the sensor unit is attached to the measuring device, The test liquid is configured to flow from the first cell into the second cell. The sensor unit according to claim 1 .

16. A measuring device that is configured to be connectable to the sensor unit according to claim 1 and includes an image capturing means for capturing an image of the active surface of the test sheet, The measuring instrument is configured to photograph the check sheet using attachment of the sensor unit to the measuring instrument as a trigger.

17. A measuring device that is configured to be connectable to the sensor unit according to claim 1 and includes an image capturing means for capturing an image of the active surface of the test sheet, The measuring device is configured to photograph the check sheet a predetermined time after the sensor unit is attached to the measuring device.

18. The test liquid is urine, The measuring device is installed in a toilet.

18. A measuring device according to claim 16 or 17.

Images