Biological component measurement device

Abstract

A biological component measurement device (1) having: a pumping light radiation unit (20) that radiates a pumping light (Pu) for causing a body part (90) that is in contact with a first surface (11) of an optical member (10) to generate heat; a probe light source (30); a light position detector (40) that detects the position of the probe light which has entered the optical member (10), propagated through a region in the vicinity of the first surface (11), and exited from the optical member (10); and a data processing unit (50) that calculates a biological component in the body part (90) on the basis of the difference (D) between a first position, which is the position of the probe light (Pr1) that has exited from the optical member (10) during a first condition in which the pumping light (Pu) is not being radiated, and a second position (Pr2), which is the position of the probe light (Pr) that has exited from the optical member (10) during a second condition in which the pumping light (Pu) is being radiated, wherein a radiation region (26) of the pumping light (Pu) in the first surface (11) extends in a predetermined extension direction.

Description

Technical Field

[0001] The present disclosure relates to a biological component measuring device.

Background Art

[0002] There has been proposed a non-invasive biological component measuring device that measures the amount of biological components (for example, carbohydrates and lipids contained in interstitial fluid) contained in a living body (see, for example, Patent Document 1). This device measures, for example, the amount of components contained in interstitial fluid by utilizing the characteristic that the calorific value generated by a living body that has absorbed pump light varies corresponding to the amount of biological components. Note that since interstitial fluid is the liquid contained in cells and exists in a region closer to the skin surface than blood vessels, when measuring biological components from the outside of the living body, the components of interstitial fluid are often measured.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, in a conventional biological component measuring device that utilizes the difference in the calorific value generated by a living body (that is, the amount of heat absorbed from pump light by the living body), improvement in the accuracy of measuring biological components has been demanded.

[0005] An object of the present disclosure is to provide a biological component measuring device capable of improving the accuracy of measuring biological components.

Means for Solving the Problems

[0006] The biological component measuring device of the present disclosure An apparatus for measuring a biological component of a living body by contacting a biological part of the living body, includes an optical member that includes a first surface of a part and in which a refractive index distribution changes corresponding to a temperature distribution, and is in contact with the first surface saidA pump light irradiation unit that irradiates pump light for heating a biological site, a probe light source that emits probe light, an optical position detector that detects the position of the probe light that has entered the optical member, propagated through a region near the first surface, and exited the optical member, and based on the difference between a first position that is the position of the probe light exiting the optical member in a first state where the pump light is not irradiated and a second position that is the position of the probe light exiting the optical member in a second state where the pump light is irradiated, the said A data processing unit that calculates a biological component, and the pump light is shaped so that the irradiation region of the pump light on the first surface extends in a first direction obtained by projecting the optical path through which the probe light propagates in the optical member onto the first surface wherein , the pump light irradiation unit includes a pump light source and an optical element that shapes the light emitted from the pump light source to generate the pump light irradiated onto the irradiation region. The optical element generates the pump light composed of a plurality of beams by splitting the light emitted from the pump light source into a plurality of beams, and the plurality of beams include -1st order light, 0th order light, and +1st order light arranged in the first direction , The probe light incident on the optical member passes through a refractive index distribution region formed by the -1st order light, the 0th order light, and the +1st order light arranged in the first direction on the first surface characterized by this. In addition, another biological component measurement device of the present disclosure An apparatus for measuring a biological component of a living body by contacting a biological part of the living body, An optical member including a first surface of a site and having a refractive index distribution that changes corresponding to a temperature distribution, and a said A pump light irradiation unit that irradiates pump light for heating a biological site, a probe light source that emits probe light, an optical position detector that detects the position of the probe light that has entered the optical member, propagated through a region near the first surface, and exited the optical member, and based on the difference between a first position that is the position of the probe light exiting the optical member in a first state where the pump light is not irradiated and a second position that is the position of the probe light exiting the optical member in a second state where the pump light is irradiated, the said A data processing unit that calculates a biological component, and the pump light is shaped so that it extends in a second direction orthogonal to a first direction obtained by projecting the optical path through which the probe light propagates in the optical member onto the first surface at the irradiation region of the pump light on the first surface wherein , the pump light irradiation unit includes a pump light source and an optical element that shapes the light emitted from the pump light source to generate the pump light irradiated onto the irradiation region. The optical element generates the pump light composed of a plurality of beams by splitting the light emitted from the pump light source into a plurality of beams, and the plurality of beams include -1st order light, 0th order light, and +1st order light arranged in the second direction , The probe light incident on the optical member passes through a refractive index distribution region formed by the -1st order light, the 0th order light, and the +1st order light arranged in the second direction on the first surface characterized by this.

Advantages of the Invention

[0007] According to the device of the present disclosure, the measurement accuracy of biological components of a biological component measuring device can be improved.

Brief Description of the Drawings

[0008]

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Embodiments for Carrying Out the Invention

[0009] Hereinafter, a biological component measuring device according to an embodiment will be described with reference to the drawings. The following embodiments are merely examples, and it is possible to appropriately combine the embodiments and appropriately change each embodiment. In each figure, the same components are denoted by the same reference numerals.

[0010] The biological component measuring device according to the embodiment is a non-invasive device for measuring the amount of biological components (for example, carbohydrates and lipids contained in the interstitial fluid of the human body). A specific example of the biological component measuring device according to the embodiment is a blood glucose measuring device that optically measures the blood glucose level from a biological body part such as a person's hand, finger, or arm. The biological component measuring device according to the embodiment optically measures the amount of biological components by utilizing the characteristic that the calorific value of the biological body corresponding to the amount of heat absorbed from the pump light by the biological body differs corresponding to the amount of biological components.

[0011] Embodiment 1. FIG. 1 is a schematic diagram showing the configuration of a biological component measuring device 1 according to Embodiment 1. The biological component measuring device 1 includes an optical member 10 having a first surface 11 that is a contact surface for contacting a biological body part 90 that is a measurement object, a pump light irradiation unit 20 that irradiates pump light (that is, excitation light) Pu, a probe light source 30 that emits probe light Pr, a light position detector 40 that detects the positions of the probe lights Pr1 and Pr2 that have passed through the optical member 10, and a data processing unit 50.

[0012] In FIG. 1 and the figures described later, the coordinate axes of the XYZ orthogonal coordinate system are shown. The X-axis is the coordinate axis in the X-axis direction, which is the first direction (X) obtained by projecting the optical path along which the probe light Pr propagates in the optical member 10 onto the first surface 11, which is the contact surface of the living body to be measured. The Y-axis is the coordinate axis in the Y-axis direction, which is the second direction (Y) orthogonal to the first direction (X) obtained by projecting the optical path along which the probe light Pr propagates in the optical member 10 onto the first surface 11. The Z-axis is the coordinate axis that is orthogonal to both the X-axis and the Y-axis and generally coincides with the propagation direction of the pump light Pu from the pump light irradiation unit 20 toward the optical member 10.

[0013] The optical member 10 is formed of a light-transmissive material (for example, glass as an optical medium) whose refractive index distribution changes corresponding to the temperature distribution. That is, a living body part 90 is in contact with the first surface 11 of the optical member 10, and a refractive index distribution region 26 having a profile corresponding to the calorific value of the living body part 90 is formed in the optical member 10. The refractive index distribution region 26 is a region where the refractive index changes corresponding to the temperature distribution of the optical member 10. In the optical member 10, the refractive index decreases in a region where the temperature rises. The optical member 10 is formed of, for example, chalcogenide glass. The optical member 10 is also called a prism. In the example of FIG. 1, the optical member 10 has a second surface 12, which is the surface opposite to the first surface 11, a third surface 13, which is the probe light incident surface where the probe light Pr is incident, and a fourth surface 14, which is the probe light exit surface where the probe light Pr1 or Pr2 exits.

[0014] The pump light irradiation unit 20 has, for example, a pump light source 21, a lens 22, and an optical element 23 for shaping the irradiation region of the pump light. The pump light irradiation unit 20 irradiates the living body part 90 in contact with the first surface 11 with the pump light Pu. The pump light Pu is emitted from the pump light irradiation unit 20, enters the optical member 10 through the second surface 12, propagates generally in the Z-axis direction in the optical member 10, and hits the living body part 90 in contact with the first surface 11. The living body part 90 that receives the pump light Pu generates heat. The calorific value at this time changes corresponding to the amount of the biological component of the living body part 90.

[0015] The pump light source 21 is, for example, a semiconductor laser capable of emitting broadband infrared light. The semiconductor laser is, for example, a quantum cascade laser (QCL).

[0016] The optical element 23 is, for example, a diffraction grating. The optical element 23 may be a hologram element. The optical element 23 is not limited to a diffraction grating and a hologram element. The optical element 23 of the pump light irradiation unit 20 is shaped so that the irradiation region of the pump light Pu on the first surface 11 extends in a predetermined extending direction. In the example of FIG. 1, the optical element 23 divides the light emitted from the pump light source 21 into three beams arranged in the X-axis direction, which is the first direction (X). The three beams are the -1st order light, 0th order light, and +1st order light generated by the optical element 23. Note that the width (outer shape) of the beam indicated by the broken line in the present application is represented by the diameter in the direction perpendicular to and intersecting the beam axis, and there are various definitions. Examples of the definition of the beam width include 1 / e 2 , or full width at half maximum (FWHM), etc. Also, the number of beams divided by the optical element 23 is not necessarily limited to three, and a plurality of beams may be used. For example, the beams to be divided can be determined by appropriately setting the grating pitch and grating depth of the diffraction grating or hologram element of the optical element 23.

[0017] The probe light source 30 emits probe light Pr. The probe light Pr enters the optical member 10 through the third surface 13, propagates through the vicinity region of the first surface 11, is totally reflected at the first surface 11, and exits from the fourth surface 14. When the pump light Pu is irradiated, a refractive index distribution region 26 is formed in the vicinity region of the first surface 11 due to the heat generation of the biological site 90. As shown in FIG. 1, when the pump light Pu is not irradiated, it is at the position of the probe light Pr1 exiting from the fourth surface 14 of the optical member 10. When the pump light Pu is irradiated, the profile of the refractive index distribution region 26 becomes larger, and it is at the position of the probe light Pr2 (a position shifted by a difference D in the Z-axis direction from Pr1) exiting from the fourth surface 14 after passing through the refractive index distribution region 26 of the optical member 10.

[0018] The optical position detector 40 detects the probe light Pr1 or Pr2 emitted from the fourth surface 14. The optical position detector 40 detects the incident positions of the probe lights Pr1 and Pr2 in the Z-axis direction.

[0019] Note that although the third surface 13 is inclined with respect to the first surface 11 and the second surface 12 so that the probe light Pr from the probe light source 30 is refracted at the third surface 13, changes its propagation direction, and reaches the refractive index distribution region 26 in the vicinity of the first surface 11, this is not the only case. The third surface 13 may be a surface perpendicular to the first surface 11 and the second surface 12 so that the probe light Pr reaches the refractive index distribution region 26 in the vicinity of the first surface 11 according to the direction setting of the incident probe light Pr on the optical member 10. Similarly, the fourth surface 14 does not necessarily have to be inclined with respect to the first surface 11 and the second surface 12. Depending on the position of the optical position detector 40, the fourth surface 14 may be a surface perpendicular to the first surface 11 and the second surface 12 so that the probe light Pr totally reflected at the first surface 11 enters the optical position detector 40. By making the third surface 13 and the fourth surface 14 perpendicular to the first surface 11 and the second surface 12, the difficulty level of the optical member 10 in the processing step is reduced, and there is an effect of suppressing the defective rate and the manufacturing cost.

[0020] The data processing unit 50 calculates the amount of the biological component in the biological site 90 based on the difference D between the first position, which is the position in the Z-axis direction of the probe light Pr1 emitted from the fourth surface 14 of the optical member 10 in the first state where the pump light Pu is not irradiated, and the second position, which is the position in the Z-axis direction of the probe light Pr2 emitted from the fourth surface 14 of the optical member 10 in the second state where the pump light Pu is irradiated. The method of obtaining the amount of the biological component in the biological site 90 based on the difference D is a known method. For example, a method of calculating by a calculation formula obtained in advance can be used.

[0021] By using the biological component measurement device 1, since the pump light of the profile extending in the first direction (X) irradiates the biological site 90, the profile of the refractive index distribution region 26 formed inside the optical member 10 is long in the first direction (X). When the probe light Pr incident on the optical member 10 passes through the refractive index distribution region 26 extending in the first direction (X), the difference D in the Z-axis direction between the probe lights Pr1 and Pr2 can be increased, so that the accuracy of measuring the amount of the biological component can be improved.

[0022] FIG. 2 is a diagram showing an example of the hardware configuration of the biological component measurement device 1 according to the first embodiment. The biological component measurement device 1 according to the first embodiment includes a processor 101 such as a CPU (Central Processing Unit), a memory 102 as a storage device such as a RAM (Random Access Memory), a storage device 103 which is a non-volatile storage device such as an HDD (Hard Disk Drive) and an SSD (Solid State Drive), and an interface 104. These configurations may be configured by a dedicated processing circuit. The processor 101, the memory 102, and the storage device 103 in FIG. 2 may be provided in an external computer, a tablet terminal, a smartphone, etc. that can receive the detection signal of the optical position detector 40 and can communicate with the control units of the probe light source 30 and the pump light source 21.

[0023] Figs. 3(A) and (B) are a plan view and a side view showing the profile of the refractive index distribution region 26 of the optical member 10 of the biological component measuring apparatus 1 according to Embodiment 1 and the optical path of the probe light Pr. In this example, the optical element 23 (for example, a diffraction grating or a hologram element) of the pump light irradiation unit 20 forms -1st order light, 0th order light, and +1st order light as a plurality of beams on the first surface 11 in the first direction (X) which is a predetermined extending direction, and the -1st order light and the 0th order light overlap with each other at the ends, and the 0th order light and the +1st order light overlap with each other at the ends. In this case, the probe light Pr incident on the optical member 10 passes through the refractive index distribution region 26 extending by being arranged in the first direction (X), so that the probe light Pr2 is more greatly affected by the refraction action of the refractive index distribution region 26, and the difference D in the Z-axis direction between the probe lights Pr1 and Pr2 can be increased, and thus the accuracy of measuring the amount of the biological component can be improved.

[0024] Figs. 4(A) and (B) are a plan view and a side view showing the profile of the refractive index distribution region 26a of the optical member 10 of the biological component measuring apparatus 1 according to Modification 1 of Embodiment 1 and the optical path of the probe light Pr. In this example, the optical element 23 of the pump light irradiation unit 20 forms -1st order light, 0th order light, and +1st order light as a plurality of beams on the first surface 11 in the predetermined extending direction, and the -1st order light, the 0th order light, and the +1st order light do not overlap with each other. In this case, the probe light Pr incident on the optical member 10 passes through the refractive index distribution region 26a extending by being arranged in the first direction (X), so that the difference D in the Z-axis direction between the probe lights Pr1 and Pr2 can be increased, and thus the accuracy of measuring the amount of the biological component can be improved.

[0025] Figs. 5(A) and (B) are a plan view and a side view showing the profile of the refractive index distribution region 26b of the optical member 10 of the biological component measuring apparatus 1 according to Modification 2 of Embodiment 1 and the optical path of the probe light Pr. In this example, on the first surface 11, the optical element 23 of the pump light irradiation unit 20 forms -1st order light, 0th order light, and +1st order light as a plurality of beams arranged in a first direction (X) which is a predetermined extending direction, and the -1st order light and the 0th order light having an elliptical shape long in the first direction (X) overlap with each other at the ends, and the 0th order light and the +1st order light overlap with each other at the ends, so as to form -1st order light, 0th order light, and +1st order light. In this case, since the probe light Pr incident on the optical member 10 passes through the refractive index distribution region 26b extended by being arranged in the first direction (X), the difference D in the Z-axis direction between the probe lights Pr1 and Pr2 can be increased, so that the accuracy of measuring the amount of the biological component can be improved.

[0026] Figs. 6(A) and (B) are a plan view and a side view showing the profile of the refractive index distribution region 26c of the optical member 10 of the biological component measuring apparatus 1 according to Modification 3 of Embodiment 1 and the optical path of the probe light Pr. In this example, on the first surface 11, the optical element 23 forms -1st order light, 0th order light, and +1st order light as a plurality of beams arranged in a first direction (X) which is a predetermined extending direction, and the -1st order light, the 0th order light, and the +1st order light have an elliptical shape long in the first direction (X), and the -1st order light, the 0th order light, and the +1st order light are formed so as not to overlap with each other at the ends. In this case, since the probe light Pr incident on the optical member 10 passes through the refractive index distribution region 26c extended by being arranged in the first direction (X), the difference D in the Z-axis direction between the probe lights Pr1 and Pr2 can be increased, so that the accuracy of measuring the amount of the biological component can be improved.

[0027] Figs. 7(A) and 7(B) are a plan view and a side view showing the profile of the refractive index distribution region 26 of the optical member 10a of the biological component measuring device 1 according to Modification 4 of Embodiment 1 and the optical path of the probe light Pr. In this example, the optical member 10a is a rectangular parallelepiped, and the third surface 13a which is the incident surface and the fourth surface 14a which is the exit surface are formed perpendicular to the first surface 11 and the second surface 12. In this example, the optical element 23 (for example, a diffraction grating or a hologram element) of the pump light irradiation unit 20 forms -1st order light, 0th order light, and +1st order light as a plurality of beams on the first surface 11 in the first direction (X) which is a predetermined extending direction, and the -1st order light and the 0th order light overlap with each other at the end, and the 0th order light and the +1st order light overlap with each other at the end. In this case, since the probe light Pr incident on the optical member 10a passes through the refractive index distribution region 26 extending by being arranged in the first direction (X), the difference D in the Z-axis direction between the probe lights Pr1 and Pr2 can be increased, so that the accuracy of measuring the amount of the biological component can be improved. Note that it is also possible to form any one of the refractive index distribution regions 26a, 26b, and 26c having the profiles shown in Figs. 4(A) and 4(B), Figs. 5(A) and 5(B), and Figs. 6(A) and 6(B) on the optical member 10a.

[0028] In Embodiment 1, it is desirable to configure the optical element 23 such that the light amount of the -1st order light and the light amount of the +1st order light are each larger than the light amount of the 0th order light. As in the examples of Figs. 3, 4, 5, and 6, when the probe light Pr is totally reflected near the 0th order light on the first surface 11, since the probe light Pr propagates obliquely with respect to the first surface 11 within the optical member 10, the distance between the probe light Pr and the first surface 11 increases as the -1st order light and the +1st order light move away from the 0th order light in the X-axis direction, and the refraction action of the probe light Pr in the refractive index distribution region generated by the -1st order light and the +1st order light in the refractive index distribution region 26 becomes weak. By making the light amount of the -1st order light and the light amount of the +1st order light each larger than the light amount of the 0th order light, the refractive index distribution region generated by the -1st order light and the +1st order light can be expanded and the refraction action of the probe light Pr can be made larger.

[0029] Embodiment 2. FIG. 8 is a schematic diagram showing the configuration of the biological component measuring apparatus 2 according to Embodiment 2. FIG. 9 is a plan view showing the profile of the refractive index distribution region 26d of the optical member 10 of the biological component measuring apparatus 2 and the optical path of the probe light Pr. In the biological component measuring apparatus 2 according to Embodiment 2, the configuration of the pump light irradiation unit 20a is different from the configuration of Embodiment 1 shown in FIG. 1. The pump light irradiation unit 20a includes a pump light source 21, a cylindrical lens 24 as an optical element, and a lens 25. As this optical element, it is also possible to use a combined prism formed by combining a plurality of prisms.

[0030] In this case, since the probe light Pr incident on the optical member 10 passes through the refractive index distribution region 26d extending in the first direction (X), the difference D in the Z-axis direction between the probe lights Pr1 and Pr2 can be increased, so that the accuracy of measuring the amount of the biological component can be improved.

[0031] In Embodiment 2, it is possible to expand the likelihood of arranging optical components and facilitate optical adjustment. Further, in Embodiment 2, it is possible to use the optical member 10a shown in FIGS. 7(A) and (B).

[0032] Embodiment 3. FIG. 10 is a plan view showing the profile of the refractive index distribution region 26e of the optical member 10 of the biological component measuring apparatus according to Embodiment 3 and the optical path of the probe light Pr. The configuration of the pump light irradiation unit of the biological component measuring apparatus according to Embodiment 3 is the same as that shown in FIG. 1, but the arrangement direction of the three beams - the -1st order light, the 0th order light, and the +1st order light - into which the pump light is split is the second direction (Y) orthogonal to the first direction (X), which is different from the apparatus of Embodiment 1. Other than this, Embodiment 3 is the same as Embodiment 1.

[0033] In the case of Embodiment 3, the likelihood of the arrangement of the probe light Pr and the pump light Pu (likelihood regarding the positional accuracy in the second direction (Y)) can be increased, facilitating optical adjustment and maintaining the accuracy of the measurement of biological components. In other words, even if the path of the probe light Pr is shifted to the probe light Pr' due to assembly error or aging deterioration, etc., the probe lights Pr1' and Pr2' that have passed through the optical member 10 can be detected, so that the accuracy of the measurement of biological components can be maintained.

[0034] Embodiment 4. FIG. 11 is a plan view showing the profile of the refractive index distribution region 26f of the optical member 10 and the optical path of the probe light in the biological component measuring apparatus according to Embodiment 4. The configuration of the pump light irradiation unit in the biological component measuring apparatus according to Embodiment 4 is the same as that shown in FIG. 8, but the difference from the apparatus of Embodiment 2 is that the extending direction of the pump light generated as the pump light is the second direction (Y) orthogonal to the first direction (X). Otherwise, Embodiment 4 is the same as Embodiment 2.

[0035] In the case of Embodiment 4, the likelihood of the arrangement of the probe light Pr and the pump light Pu (likelihood regarding the positional accuracy in the second direction (Y)) can be increased, facilitating optical adjustment and maintaining the accuracy of the measurement of biological components. In other words, even if the path of the probe light Pr is shifted to the probe light Pr' due to assembly error or aging deterioration, etc., the probe lights Pr1' and Pr2' that have passed through the optical member 10 can be detected, so that the accuracy of the measurement of biological components can be maintained.

Description of Reference Numerals

[0036] 1. 2-component biological measurement device, 10, 10a optical members, 11 first surface (contact surface), 12 second surface, 13 third surface (probe light incident surface), 14 fourth surface (probe light exit surface), 20, 20a pump light irradiation units, 21 pump light source, 22 lens, 23 pump light shaping element (optical element), 24 cylindrical lens (optical element), 25 lens, 26, 26a - 26f refractive index distribution regions, 30 probe light source, 40 light position detector, 50 data processing unit, 90 biological site, Pu pump light, Pr probe light, Pr1 probe light, Pr2 probe light, Pr' probe light, Pr1' probe light, Pr2' probe light, X first direction, Y second direction.

Claims

Claim 1: A biological component measuring device that contacts a biological part of a living body and measures a biological component of the living body, an optical member including a first surface of a part, in which a refractive index distribution changes corresponding to a temperature distribution; a pump light irradiation unit that irradiates pump light for heating the biological part in contact with the first surface; a probe light source that emits probe light; a light position detector that detects a position of the probe light that has entered the optical member, propagated through a vicinity region of the first surface, and exited from the optical member; a data processing unit that calculates the biological component in the biological part based on a difference between a first position that is the position of the probe light exiting from the optical member in a first state where the pump light is not irradiated and a second position that is the position of the probe light exiting from the optical member in a second state where the pump light is irradiated; comprising: the pump light is shaped so that an irradiation region of the pump light on the first surface extends in a first direction obtained by projecting an optical path through which the probe light propagates in the optical member onto the first surface; the pump light irradiation unit includes a pump light source and an optical element that shapes light emitted from the pump light source to generate the pump light irradiated to the irradiation region; the optical element generates the pump light composed of a plurality of beams by splitting the light emitted from the pump light source into the plurality of beams; the plurality of beams include a -1st order light, a 0th order light, and a +1st order light arranged in the first direction; the probe light entering the optical member passes through a refractive index distribution region formed by arranging the -1st order light, the 0th order light, and the +1st order light in the first direction on the first surface; A biological component measuring device characterized by the above. Claim 2 On the first surface, the optical element forms the −1st order light, the 0th order light, and the +1st order light such that the −1st order light and the 0th order light overlap with each other at their ends, and the 0th order light and the +1st order light overlap with each other at their ends. The biological component measuring device according to claim 1, wherein the device is characterized by the above.

3. On the first surface, the optical element forms the −1st order light, the 0th order light, and the +1st order light such that the −1st order light, the 0th order light, and the +1st order light do not overlap with each other. The biological component measuring device according to claim 1, wherein the device is characterized by the above.

4. The optical element is configured such that each of the light quantity of the −1st order light and the light quantity of the +1st order light is larger than the light quantity of the 0th order light. The biological component measuring device according to claim 3, wherein the device is characterized by the above.

5. A biological component measuring device that measures a biological component of a living body by contacting a biological part of the living body, an optical member including a first surface of the part, the refractive index distribution of which changes corresponding to the temperature distribution; a pump light irradiation unit that irradiates pump light for heating the biological part in contact with the first surface; a probe light source that emits probe light; a light position detector that detects the position of the probe light that has entered the optical member, propagated through a region near the first surface, and exited from the optical member; a data processing unit that calculates the biological component in the biological part based on the difference between a first position that is the position of the probe light emitted from the optical member in a first state where the pump light is not irradiated and a second position that is the position of the probe light emitted from the optical member in a second state where the pump light is irradiated; and has the pump light is shaped to extend in a second direction orthogonal to a first direction obtained by projecting an optical path through which the probe light propagates in the optical member onto the first surface, where the irradiation region of the pump light on the first surface is located. The pump light irradiation unit includes a pump light source and an optical element that shapes the light emitted from the pump light source to generate the pump light irradiated onto the irradiation region. The optical element generates the pump light composed of the plurality of beams by splitting the light emitted from the pump light source into a plurality of beams. The plurality of beams include -1st order light, 0th order light, and +1st order light arranged in the second direction. The probe light incident on the optical member passes through a refractive index distribution region formed on the first surface by the -1st order light, the 0th order light, and the +1st order light being arranged in the second direction. A biological component measuring device characterized by the above.

6. The optical element forms the -1st order light, the 0th order light, and the +1st order light such that the -1st order light and the 0th order light overlap each other at an end portion and the 0th order light and the +1st order light overlap each other at an end portion on the first surface. The biological component measuring device according to claim 5, characterized by the above.

7. The optical element is a diffraction grating or a hologram element. The biological component measuring device according to any one of claims 1 to 6, characterized by the above.

8. The optical element is a synthetic prism. The biological component measuring device according to any one of claims 1 to 6, characterized by the above.

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