Liquid detergent composition

Abstract

Provided is a cleaning composition that has little skin irritation, good detergency and rinsability, and excellent bactericidal and virus-inactivating effects even in the presence of organic dirt. 【Solution means】The present invention provides a liquid alkaline cleaning composition for skin, which contains an alkyltrimethylammonium salt as component (A-α), an alkyldimethylbenzylammonium salt as component (A-β), a pH adjuster as component (B), at least one selected from a nonionic surfactant and an amphoteric surfactant as component (C), a polyhydric alcohol as component (D), and water as component (E), wherein the total amount of the component (A-α) and the component (A-β) is less than 0.6% by mass, the value of the mass ratio (A-α) / (A-β) of the mass of the component (A-α) to the mass of the component (A-β) is 0.01 or more and less than 1, and the pH at 25°C is 8.0 or more and 12.0 or less.

Description

Technical Field

[0001] The present invention relates to an alkaline liquid detergent composition for skin. More specifically, it mainly relates to a detergent composition used for washing fingers, having little skin irritation, good detergency and rinsability, and excellent bactericidal effect and virus inactivating effect even in the presence of organic dirt.

[0002] Regarding the cleaning and disinfection of fingers of employees in the food-related industry such as meat and seafood processing and restaurant kitchens, and doctors, nurses, caregivers, patients, etc. in hospitals, health centers, etc., various methods have been conventionally adopted. The most common method is to first thoroughly wash the fingers with a finger detergent and then undergo a disinfection treatment such as immersion or spraying of the fingers with a disinfectant. These methods can be said to be effective when carried out faithfully according to the cleaning and disinfection manuals. However, when the finger washing is insufficient, there is a problem that the bactericidal power by the subsequent disinfection treatment is extremely reduced, and there is a case of bringing microorganisms that cause food poisoning to the site.

[0003] In recent years, the number of cases and patients of food poisoning caused by norovirus has been increasing in the food poisoning occurrence situation, and it has become a major problem due to its high infectivity. The causes of food poisoning by norovirus are not only factors such as eating bivalves such as oysters, but also secondary infections caused by contact with human feces, vomit, and eating contaminated foods through cooks infected with norovirus are also major factors.

[0004] In order to prevent the introduction of food poisoning bacteria and secondary contamination by norovirus, thorough handwashing is required, and it is important that food manufacturers and cooks do not bring microorganisms and viruses to the site.

[0005] Furthermore, it is generally known that the bactericidal effect of bactericides and the like decreases in the presence of organic dirt. Food manufacturers and cooks may have organic dirt from food adhering to them, and there is a risk that the bactericidal effect and virus inactivating effect of hand cleaners will be difficult to exert. For this reason, hand cleaners are required to obtain a bactericidal effect and a virus inactivating effect even in the presence of organic dirt.

[0006] As cleaners used for conventional hand washing applications, there are liquid detergent compositions containing fatty acids, alkylaminocarboxylic acid type amphoteric surfactants, chelating agents, and having a pH of 9.5 to 11 (Patent Document 1), an anionic surfactant having a specific structure as component (A), a glyceryl ether having a hydrocarbon group with 4 to 22 carbon atoms as component (B), at least one bactericide selected from the group consisting of triclosan, isopropylmethylphenol, and parachlorometaxylenol as component (C), an alkyl glycoside as component (D), and a saturated monohydric alcohol having 1 to 3 carbon atoms as component (E), and the mass ratio (B) / (E) of component (B) to component (E) is 0.10 to 5 (Patent Document 2), a skin cleansing composition containing a quaternary ammonium salt type surfactant as component (A), a pH adjuster as component (B), at least one selected from nonionic surfactants and amphoteric surfactants as component (C), water as component (D), and a polyhydric alcohol as component (E), the mass ratio of component (A) to component (B) is 0.002 or more and 100 or less in terms of the value of (A) / (B), the mass ratio of component (A) to component (E) is 0.001 or more and 1 or less in terms of the value of (A) / (E), and the pH at 25°C is 8.1 or more and 12.0 or less (Patent Document 4). In addition, as a technology related to the virus inactivating effect, there is an antiviral cleaning composition containing a quaternary ammonium salt, a nonionic surfactant and / or an amphoteric surfactant, and an alkaline agent, and having a pH of 11 or more at 25°C (Patent Document 3).

Prior Art Documents

Patent Documents

[0007] Patent Document 1 International Publication No. 2013 / 141118 Patent Document 2 Japanese Unexamined Patent Application Publication No. 2020-026407 Patent Document 3 Japanese Unexamined Patent Application Publication No. 2019-052118 Patent Document 4 Japanese Patent No. 6860734 Summary of the Invention Problems to be Solved by the Invention

[0008] The liquid detergent composition of Patent Document 1 has a certain detergency because its pH is in the alkaline range, but its bactericidal effect is not sufficient, and no virus inactivation effect can be obtained. Although the skin detergent composition of Patent Document 2 has a bactericidal effect and detergency, no virus inactivation effect can be obtained because its pH is in the neutral range. The antiviral detergent composition of Patent Document 3 can inactivate viruses and wash the object to be washed by wiping with an antiviral cleaning material impregnated into a non-woven fabric or spraying with a spray and then rinsing with water for objects to be washed having hard surfaces such as cooking tables, refrigerators, toilets, and floors. However, since it is highly irritating to the skin, operators need to wear gloves for work. The liquid detergent composition of Patent Document 4 can be used for washing fingers, has little skin irritation, and is excellent in detergency, bactericidal effect, and virus inactivation effect. However, there is room for improvement in the bactericidal effect and virus inactivation effect in the presence of organic dirt.

[0009] The present invention is an invention found to solve the above problems. That is, an object of the present invention is to provide a detergent composition that has little skin irritation, good detergency and rinsability, and excellent bactericidal effect and virus inactivation effect even in the presence of organic dirt. Means for Solving the Problems

[0010] In order to solve the above problems, as a result of intensive studies, the present inventors have found that a composition containing an alkyltrimethylammonium salt as the (A-α) component, an alkyldimethylbenzylammonium salt as the (A-β) component, a pH adjuster as the (B) component, at least one selected from nonionic surfactants and amphoteric surfactants as the (C) component, a polyhydric alcohol as the (D) component, and water as the (E) component, and further containing the total amount of the (A-α) component and the (A-β) component within a specific range and having a specific ratio of the (A-α) component to the (A-β) component has low irritation to the skin, excellent detergency, and good bactericidal and virus-inactivating effects even in the presence of organic dirt. Based on these findings, the present invention has been completed.

[0011] That is, the skin alkaline liquid detergent composition of the present invention contains an alkyltrimethylammonium salt as the (A-α) component, an alkyldimethylbenzylammonium salt as the (A-β) component, and as the (B) component, Composed of a combination of an alkali metal hydroxide and / or an alkanolamine and at least one selected from alkali metal carbonates, alkali metal phosphates, and organic acid salts a pH adjuster, and as the (C) component , 0.1% by mass or more and 6% by mass or less at least one selected from nonionic surfactants and amphoteric surfactants, a polyhydric alcohol as the (D) component, , at least one selected from the group consisting of ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,4-butanediol, 1,5-pentanediol, hexylene glycol, glycerin, polyglycerin, and sorbitol and water as the (E) component, wherein the total amount of the (A-α) component and the (A-β) component is 0.06% by mass or more and 0.5% by mass or less and the value of the mass ratio (A-α) / (A-β) of the mass of the (A-α) component to the mass of the (A-β) component is 0.06 or more and 0.75 or less and the pH at 25°C is 8.0 or more and 12.0 or less.

[0012] Further, in the present invention, it is preferable that the value of the mass ratio (C) component / (A) component of the mass of the (C) component to the mass of the (A) component is 0.1 or more and 150 or less. 。

[0013] Further, in the present invention, as the (C) component, it is preferable to contain at least one selected from polyoxyalkylene alkyl ethers, alkyl glucosides including alkyl polyglucosides, alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, alkylamino (mono- or di-) propionates, and alkyldimethylamine oxides.

[0014] Moreover, in the present invention, it is preferable that the composition contains at least one selected from ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, and sorbitol as the component (D). In the present invention, it is preferable that the above-described liquid alkaline detergent composition for skin is a liquid detergent for fingers.

Advantages of the Invention

[0015] The liquid alkaline detergent composition for skin of the present invention is excellent in bactericidal effect and virus inactivating effect against bacteria in the presence of organic dirt.

Embodiments for Carrying Out the Invention

[0016] The liquid alkaline detergent composition for skin of the present invention contains an alkyltrimethylammonium salt as the component (A-α), an alkyldimethylbenzylammonium salt as the component (A-β), a pH adjuster as the component (B), at least one selected from a nonionic surfactant and an amphoteric surfactant as the component (C), a polyhydric alcohol as the component (D), and water as the component (E), wherein the total amount of the component (A-α) and the component (A-β) is less than 0.6% by mass, and the value of the mass ratio (A-α) / (A-β) of the mass of the component (A-α) to the mass of the component (A-β) is 0.01 or more and less than 1.

[0017] (A-α) Alkyltrimethylammonium salt The alkyltrimethylammonium salt used in the present invention is represented by the general formula ([R 1 N(CH3)3〕 + ·X - ). Here, R 1 is a linear or branched alkyl group having 8 to 22 carbon atoms, and X represents a halogen atom. R 1Examples thereof include alkyl groups such as an octyl group, a nonyl group, a decyl group, an undecyl group, a lauryl group, a tridecyl group, a myristyl group, a pentadecyl group, a heptadecyl group, a stearyl group, a nonadecyl group, and an eicosyl group. Among these, an alkyl group having 10 to 18 carbon atoms is preferable, an alkyl group having 12 to 18 carbon atoms is more preferable, an alkyl group having 14 to 18 carbon atoms is still more preferable, and an alkyl group having 16 carbon atoms is most preferable.

[0018] X represents a group that forms a counter ion, and examples thereof include a halogen atom and an alkyl sulfate. Among these, a halogen atom, particularly a chlorine atom and a bromine atom, is preferable.

[0019] Specific examples of the alkyltrimethylammonium salt include lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, coconut alkyltrimethylammonium chloride, alkyl (C14-C18) trimethylammonium chloride, alkyl (C16-C18) trimethylammonium chloride, behenyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium bromide, etc. Among these, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, coconut alkyltrimethylammonium chloride, alkyl (C14-C18) trimethylammonium chloride, alkyl (C16-C18) trimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium bromide are preferred, lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, alkyl (C14-C18) trimethylammonium chloride, alkyl (C16-C18) trimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium bromide are more preferred, and cetyltrimethylammonium chloride and cetyltrimethylammonium bromide are even more preferred.

[0020] (A-β) alkyldimethylbenzylammonium salt The alkyldimethylbenzylammonium salt used in the present invention is represented by the general formula ([C6H5CH2N(CH3)2R 2 〕 + ·X - ). Here, R 2 represents a linear or branched alkyl group having 8 to 18 carbon atoms. Examples of R 2 include octyl group, nonyl group, decyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, and octadecyl group. Among these, R2 is preferably a C12 - C16 alkyl group.

[0021] X represents a group forming a counter ion, and examples thereof include a halogen atom and alkyl sulfate. Among these, a halogen atom, particularly a chlorine atom, is preferred.

[0022] Examples of the alkyldimethylbenzylammonium salt include alkyl (C12 - C16) dimethylbenzylammonium chloride, octyldimethylbenzylammonium chloride, decyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, etc. Among these, alkyl (C12 - C16) dimethylbenzylammonium chloride is preferred.

[0023] Component (A) contributes to the bactericidal power and virus inactivation in the alkaline liquid skin cleansing composition of the present invention. Therefore, if the blending amounts of component (A-α) and component (A-β) are too small, the bactericidal power or virus inactivation effect of the alkaline liquid skin cleansing composition may be insufficient. On the other hand, if the blending amounts of component (A-α) and component (A-β) are too large, the skin irritation may become strong, and it may have an undesirable influence on the rinsability and storage stability. From such a viewpoint, the total concentration of component (A-α) and component (A-β) in the alkaline liquid skin cleansing composition of the present invention is preferably less than 0.6% by mass, more preferably 0.01% by mass or more and less than 0.6% by mass, still more preferably 0.03% by mass or more and 0.57% by mass or less, and particularly preferably 0.10% by mass or more and 0.50% by mass or less.

[0024] The alkaline liquid detergent composition for skin of the present invention may contain a quaternary ammonium salt type surfactant other than the component (A-α) and the component (A-β) (hereinafter referred to as "other quaternary ammonium salts") as long as the effects of the present invention are not impaired. However, the total amount of the component (A-α) and the component (A-β) is preferably at least 80% by mass, more preferably at least 90% by mass, and particularly preferably at least 95% by mass with respect to the total amount of the component (A-α), the component (A-β), and other quaternary ammonium salts. Further, as another embodiment, the alkaline liquid detergent composition for skin of the present invention does not contain other quaternary ammonium salts. Further, the total amount of the component (A-α), the component (A-β), and other quaternary ammonium salts is preferably less than 0.6% by mass with respect to the total amount of the alkaline liquid detergent composition for skin.

[0025] From the viewpoints of bactericidal power and virus inactivation effect, the component (A-α) used in the present invention is preferably 0.005% by mass or more and 0.3% by mass or less, more preferably 0.008% by mass or more and 0.27% by mass or less, still more preferably 0.01% by mass or more and 0.24% by mass or less, and particularly preferably 0.01% by mass or more and 0.15% by mass or less with respect to the total amount of the alkaline liquid detergent composition for skin of the present invention.

[0026] The component (A-β) used in the present invention is preferably 0.005% by mass or more and 0.59% by mass or less, more preferably 0.01% by mass or more and 0.5% by mass or less, still more preferably 0.05% by mass or more and 0.3% by mass, and particularly preferably 0.1% by mass or more and 0.2% by mass or less with respect to the total amount of the alkaline liquid detergent composition for skin of the present invention. If the component (A-β) is less than 0.005% by mass, sufficient bactericidal power and virus inactivation effect cannot be obtained. Further, if it is more than 0.59% by mass, skin irritation may become strong, and the rinsability and storage stability may decrease.

[0027] In the alkaline liquid detergent composition for skin of the present invention, the value of the mass ratio (A-α) / (A-β) of the mass of the component (A-α) to the mass of the component (A-β) is required to be 0.01 or more and less than 1. This value is preferably 0.02 or more and 0.9 or less, more preferably 0.06 or more and 0.8 or less, and particularly preferably 0.1 or more and 0.75 or less. If this value is less than 0.01, a decrease in bactericidal power is recognized, and if it is 1.0 or more, a decrease in the virus inactivation effect is recognized.

[0028] Here, the virus includes an enveloped virus which is a virus having an envelope, and a non-enveloped virus which is a virus having no envelope.

[0029] Examples of the virus having an envelope include, but are not limited to, human herpes virus, vaccinia virus, influenza virus, SARS coronavirus, MERS coronavirus, SARS-CoV-2, RS virus, mumps virus, Lassa virus, dengue virus, rubella virus, human immunodeficiency virus, measles virus, hepatitis B virus, hepatitis C virus, Ebola virus, yellow fever virus, and Japanese encephalitis virus.

[0030] Examples of the virus having no envelope include, but are not limited to, norovirus, poliovirus, echovirus, rhinovirus, astrovirus, rotavirus, coxsackievirus, enterovirus, sapovirus, adenovirus, human parvovirus B19 virus, human papillomavirus, hepatitis A virus, and hepatitis E virus.

[0031] (B) pH adjuster Component (B) is a pH adjuster for adjusting the pH of the liquid alkaline detergent composition for skin of the present invention. Considering the blending amounts of other components, the pH of the liquid detergent composition of the present invention is preferably adjusted to a range of 8.0 or more and 12.0 or less by component (B). General alkaline detergents are strongly irritating to the skin and direct use on fingers is avoided. However, the present invention, although alkaline, can exhibit high detergency, bactericidal power, and virus inactivating effect (hereinafter, these are also referred to as detergency, etc.) while suppressing irritation to the skin due to the blending of component (A) and component (C).

[0032] From the viewpoint of more fully exhibiting detergency, bactericidal power, and virus inactivating effect, the above pH is preferably 9 or more, more preferably 9.5 or more. Also, from the viewpoint of providing a detergent with less skin irritation, the above pH is preferably 11.5 or less, more preferably 11 or less, and particularly preferably less than 11.

[0033] As the above pH adjuster, it can be selected from compounds capable of adjusting the pH of the liquid detergent composition without impairing the effects of the present invention. For example, as the pH adjuster, any one or combination selected from alkali metal hydroxides, alkali metal silicates, alkanolamines, alkali metal carbonates, alkali metal phosphates, and organic acid salts can be mentioned.

[0034] Examples of the alkali metal hydroxide include sodium hydroxide, potassium hydroxide, and the like. Examples of the alkali metal silicate include sodium orthosilicate, potassium orthosilicate, sodium metasilicate, potassium metasilicate, sodium silicate No. 1, sodium silicate No. 2, sodium silicate No. 3, potassium A silicate, potassium B silicate, or potassium C silicate, and the like. Examples of the alkanolamine include monoethanolamine, diethanolamine, or triethanolamine, and the like. Examples of the alkali metal carbonate include sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium sesquicarbonate, potassium sesquicarbonate, sodium percarbonate, potassium percarbonate, and the like. Examples of the alkali metal phosphate include sodium phosphate, potassium phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, and the like. Examples of the organic acid salt include sodium citrate, potassium citrate, trisodium citrate, tripotassium citrate, sodium gluconate, potassium gluconate, sodium lactate, potassium lactate, sodium acetate, potassium acetate, and the like.

[0035] From the viewpoint of detergency, the component (B) is preferably an alkali metal hydroxide or an alkanolamine. Further, from the viewpoint of good virus inactivation against the object to be cleaned to which organic dirt is attached, it is preferable to use in combination an alkali metal hydroxide and / or an alkanolamine with at least one selected from alkali metal carbonates, alkali metal phosphates, and organic acid salts. It is presumed that due to the buffering action of the carbonate, phosphate or organic acid salt, the decrease in pH is suppressed even when dirt is attached, and an excellent virus inactivation effect is exhibited.

[0036] The proportion of the component (B) with respect to the total amount of the liquid detergent composition for skin of the present invention is preferably 0.05% by mass or more and 5.0% by mass or less, more preferably 0.1% by mass or more and 4.0% by mass or less, and particularly preferably 0.3% by mass or more and 3.0% by mass or less. If it is less than 0.05% by mass, the bactericidal power and virus inactivation effect may not be sufficient. If it is more than 5% by mass, the skin irritation may increase and the storage stability may decrease.

[0037] When a general liquid detergent composition is brought into contact with an object to be washed having dirt such as organic matter adhering thereto, the pH of the liquid detergent composition may significantly decrease. As a result, the detergency and the like deteriorate, and the object to be washed is not sufficiently washed and sterilized. And there is a problem that sufficient sterilization cannot be achieved even when a disinfectant or the like is sprayed on an object to be washed with dirt remaining thereon for sterilization treatment. On the other hand, in the liquid detergent composition of the present invention, since the pH is adjusted to a predetermined range by the pH adjuster as the component (B), even when it comes into contact with organic dirt, it is easy to maintain alkalinity, and as a result, high detergency and the like are easily maintained. Weak bases such as sodium hydrogen carbonate, potassium hydrogen carbonate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium citrate, and tripotassium citrate can suppress a decrease in the pH of the liquid detergent composition even when in contact with dirt by a buffering action, maintain high detergency and the like, and can favorably exhibit a virus inactivating effect on an object to be washed having organic dirt adhering thereto.

[0038] (C) Nonionic surfactant · Amphoteric surfactant The skin alkaline liquid detergent composition of the present invention contains at least one selected from nonionic surfactants and amphoteric surfactants as the component (C). These surfactants contribute to realizing good detergency while suppressing irritation to the skin, and also contribute to good foaming during use.

[0039] Examples of the nonionic surfactant as the component (C) include aliphatic alkanolamides, polyoxyalkylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene polyoxypropylene glycols, sucrose fatty acid esters, monoglycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, alkylene oxide adducts of sorbitan fatty acid esters, or alkyl glucosides. The carbon number of the above alkyl group is not particularly limited, but is preferably 6 or more and 14 or less. More specifically, octyl glucoside, decyl glucoside, lauryl glucoside, etc. may be mentioned.

[0040] Examples of the amphoteric surfactant as the above component (C) include betaine-type amphoteric surfactants, amino acid-type amphoteric surfactants, amine oxide-type amphoteric surfactants, and the like.

[0041] Regarding the present invention, the betaine-type amphoteric surfactant refers to a surfactant having betaine in its molecular structure and exhibiting amphiphilicity thereby. Here, betaine refers to an inner salt having a positive charge and a negative charge at non-adjacent positions within the same molecule. The above betaine-type amphoteric surfactants include alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, and fatty acid amide propyl betaine-type amphoteric surfactants.

[0042] Examples of the above alkyl betaine-type amphoteric surfactants include alkyl dimethylaminoacetic acid betaine, alkyl dimethylaminosulfobetaine, alkyl hydroxysulfobetaine, etc. The carbon number of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less. More specifically, lauryl dimethylaminoacetic acid betaine, stearyl dimethylaminoacetic acid betaine, etc. may be mentioned. Examples of the above alkyl imidazolinium betaine-type amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, 2-alkyl-N-carboxyethyl-N-hydroxyethyl imidazolinium betaine, etc. The carbon number of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less. Examples of the above alkylamidopropyl betaine type amphoteric surfactants include coconut oil fatty acid amidopropyl betaine, palm oil fatty acid amidopropyl betaine, lauric acid amidopropyl betaine, myristic acid amidopropyl betaine, ricinoleic acid amidopropyl betaine, and the like. The number of carbon atoms of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less.

[0043] Regarding the present invention, examples of the amino acid type amphoteric surfactants include alkyldiaminoethyl glycine, alkylaminopropyl glycine, glycine n-(3-aminopropyl) C10-16 derivatives, alkylpolyaminoethyl glycine, carboxymethyl glycine, alkylamino (mono- or di-) propionate, alkylaminodiacetate, and the like. The number of carbon atoms of the above alkyl group is not particularly limited, but is preferably 8 or more and 16 or less. More specifically, dodecyldiaminoethyl glycine, tetradecyldiaminoethyl glycine, dodecyldiaminoethyl glycine chloride, tetradecyldiaminoethyl glycine chloride, sodium lauryl propionate, sodium laurylaminodipropionate, and the like can be mentioned.

[0044] Regarding the present invention, examples of the amine oxide type amphoteric surfactants include alkyldimethylamine oxide, alkylamidopropyldimethylamine oxide, dihydroxyethylalkylamine oxide, and the like. The number of carbon atoms of the above alkyl group is not particularly limited, but is preferably 8 or more and 18 or less. More specifically, octyldimethylamine oxide, decyldimethylamine oxide, lauryldimethylamine oxide, myristyldimethylamine oxide, coconut oil alkyldimethylamine oxide, lauric acid amidopropyldimethylamine oxide, dihydroxyethyl coconut oil alkylamine oxide, and the like can be mentioned.

[0045] From the viewpoint of providing a liquid detergent composition exhibiting more favorable foaming and rinsing properties, as the component (C) described above, it is preferable to contain at least one selected from polyoxyalkylene alkyl ethers such as polyoxyethylene alkyl ether, alkyl glucoside, alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, alkylamino (mono- or di-) propionates, and alkyl dimethylamine oxides. Among them, as the component (C), it is more preferable to contain at least one of alkyl glucoside containing alkyl polyglucoside, alkyl betaine-type amphoteric surfactants, and alkyl imidazolinium betaine-type amphoteric surfactants.

[0046] The content of the nonionic surfactant or amphoteric surfactant as the component (C) can be appropriately determined within a range that does not impair the effects of the present invention. With respect to the total amount of the skin alkaline liquid detergent composition, the proportion of the component (C) is preferably 0.1% by mass or more and 8.0% by mass or less, more preferably 0.5% by mass or more and 6% by mass or less, and particularly preferably 1.0% by mass or more and 6% by mass or less. When the component (C) is less than 0.1% by mass, good foaming may not be obtained, and when it is higher than 8.0% by mass, the storage stability may decrease.

[0047] In the skin alkaline liquid detergent composition of the present invention, the value of the mass ratio (C) / (A) of the mass of the component (C) to the mass of the component (A) is preferably 0.1 or more and less than 150, more preferably 0.2 or more and 130 or less, and even more preferably 0.8 or more and 100 or less. By including this value within the above range, it is possible to achieve both good foaming and bactericidal power.

[0048] (D) Polyhydric alcohol The skin alkaline liquid detergent composition of the present invention contains a polyhydric alcohol as the component (D). By blending the component (D), it is possible to further reduce the skin irritation of the skin alkaline liquid detergent composition having a high pH.

[0049] Examples of the component (D) include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,4-butanediol, 1,5-pentanediol, hexylene glycol, glycerin, polyglycerin, sorbitol, etc. Among them, ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, and sorbitol are preferred, and particularly glycerin, propylene glycol, and polyethylene glycol are preferred.

[0050] From the viewpoint of exerting the effect of suppressing skin irritation, the blending amount of the component (D) is preferably 0.1% by mass or more and 10% by mass or less, more preferably 0.5% by mass or more and 8% by mass or less, and particularly preferably 1% by mass or more and 6% by mass or less, based on the total amount of the liquid alkaline detergent composition for skin. If the concentration of the component (D) is less than 0.1% by mass, the effect of suppressing skin irritation may not be sufficient, and even if it is blended in an amount more than 10% by mass, no effect commensurate with the blending amount is observed.

[0051] (E) Water The liquid detergent composition of the present invention contains water as component (E). There are no particular limitations on the water as the above-mentioned component (E), and tap water, softened water, pure water, RO water, ion-exchanged water, and distilled water can be used. Examples of tap water include tap water in Arakawa-ku, Tokyo (pH = 7.6, total alkalinity (in terms of calcium carbonate) 40.5 mg / L, German hardness 2.3 °DH (of which calcium hardness is 1.7 °DH and magnesium hardness is 0.6 °DH), chloride ion 21.9 mg / L, sodium and its compounds 15 mg / L, nitrate nitrogen and nitrite nitrogen 1.2 mg / L, fluorine and its compounds 0.1 mg / L, boron and its compounds 0.04 mg / L, total trihalomethane 0.016 mg / L, residual chlorine 0.4 mg / L, organic matter (total organic carbon content) 0.7 mg / L). The water of component (E) of the present invention is the remainder with respect to the total amount of the above-mentioned components (A) to (D), or the remainder with respect to the total amount of components (A) to (D) and other optional components.

[0052] The liquid detergent composition of the present invention may contain other components commonly used in the art as needed, as long as the effects of the present invention are not impaired. Such components include, for example, fatty acids such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, coconut fatty acid or salts thereof, metal corrosion inhibitors such as benzotriazole, tolyltriazole, benzothiazole, 1-hydroxyethylidene-1,1-diphosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, aminotrimethylenephosphonic acid, alcohol solvents such as ethanol, isopropanol, phenoxyethanol, glycol ether solvents such as diethylene glycol monobutyl ether, dipropylene glycol monobutyl ether, chelating agents such as ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, triethylenetetraminehexaacetic acid, methylglycine diacetic acid, glutamic acid diacetic acid or salts thereof, bactericides such as isopropylmethylphenol, triclosan, trichlocarban, thickeners such as xanthan gum, inorganic electrolytes such as sodium chloride, fragrances, dyes and the like. Among the above components, fatty acids are preferably formulated in terms of foamability and rinsability, alcohol solvents are preferably formulated in terms of bactericidal power, glycol ether solvents are preferably formulated in terms of storage stability, and thickeners and inorganic electrolytes are preferably formulated in terms of foamability. When the above alcohol solvent is contained in the liquid detergent composition from the viewpoint of improving the bactericidal power while suppressing skin irritation, the alcohol solvent is preferably contained in a range of, for example, 0.01% by mass or more and 1.0% by mass or less, more preferably in a range of 0.05% by mass or more and 0.8% by mass or less, and even more preferably in a range of 0.1% by mass or more and 0.6% by mass or less.

[0053] In the case of the skin alkaline liquid detergent composition of the present invention, when each component is a liquid, it is generally mixed and stirred, and when it contains solid components, it is first dissolved in water and then other liquid components are added and mixed and stirred. However, depending on the composition, the addition order, dissolution order, and manufacturing procedures such as heating / cooling performed as needed of each component are not particularly limited.

[0054] The alkaline liquid detergent composition for skin of the present invention can be used by foaming the liquid detergent composition with the palm of the hand or with a sponge, etc., or can be filled in a former container and used as a foamy detergent extruded from the former container when in use.

[0055] The alkaline liquid detergent composition for skin of the present invention preferably has the skin of a human as the object of washing, and more preferably is used as a so-called hand soap for washing fingers and the like. Further, the time when washing is performed using the alkaline liquid detergent composition for skin of the present invention is not particularly limited, but from the viewpoint of more thoroughly washing the fingers, it is preferably 10 seconds or more and less than 90 seconds, and more preferably 20 seconds or more and less than 60 seconds.

Examples

[0056] Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. Each component used in the formulation of the liquid detergent compositions of the Examples and Comparative Examples is shown in Tables 1 to 7 below. Incidentally, the numerical values regarding the formulation amounts shown in Tables 1 to 7 below are the ratios (mass %) of the pure components of each component to the liquid detergent composition. Note that Examples 1 to 22, 37, 38, and 40 are reference examples.

[0057] (Component (A)) A-α1: Hexadecyltrimethylammonium chloride A-α2: Stearyltrimethylammonium chloride A-α3: Lauryltrimethylammonium chloride A-α4: Alkyl (C14 - C18) trimethylammonium chloride A-β: Alkyl (C12 - C16) dimethylbenzylammonium chloride A-γ: Dialkyl (C10) methylhydroxyethylammonium propionate

[0058] (Component (B)) B-1: Potassium hydroxide B-2: Monoethanolamine B-3: Sodium hydrogen carbonate B-4: Sodium carbonate B-5: Trisodium citrate B-6: Disodium hydrogen phosphate B-7: Sodium dihydrogen phosphate

[0059] (C) component C-1: Lauryl glucoside C-2: Lauramidopropyl betaine C-3: Sodium lauryldiaminopropionate C-4: 2-Alkyl (C8-C18)-N-carboxyethyl-N-hydroxyethylimidazolinium betaine C-5: Polyoxyethylene alkyl ether (having a straight-chain hydrocarbon group with 12 carbon atoms and an average added mole number of oxyethylene groups = 7.) C-6: Lauryl dimethylamine oxide

[0060] (D) component D-1: Glycerin D-2: Propylene glycol D-3: Polyethylene glycol (weight-average molecular weight 400)

[0061] (E) component E-1: Ion-exchanged water

[0062] Other components F-1: Disodium ethylenediaminetetraacetate F-2: Trisodium methylglycinediacetate F-3: Tetrasodium glutamate diacetate F-4: Sodium chloride F-5: Ethanol F-6: Phenoxyethanol

[0063] ※1: Cleaning performance test <Test method> This test was conducted once a day after work on 10 panelists who perform office work and on-site work in accordance with the instruction manual, using a wiping test tool (Lucipac (registered trademark) PEN; manufactured by Kikkoman Corporation). One type of liquid detergent composition was used per day in the test. First, the cotton swab set on the main body of the above-mentioned Lucipac PEN was pulled out, and both hands of each panelist were wiped with the cotton swab before handwashing, and this was used as a wiping sample. The above wiping sample was returned to the main body of the Lucipac PEN and sufficiently immersed in a luminescent reagent in the measurement tube provided at the tip of the Lucipac PEN. Then, using a luminescence measurement device (Lumitester (registered trademark) PD-30; manufactured by Kikkoman Corporation), the Lucipac PEN was inserted into the measurement chamber of the above Lumitester PD-30, and the ATP luminescence amount (RLU0) before handwashing was measured.

[0064] After preparing the above wiping sample, each panelist took 1 mL of the liquid detergent composition in their hand, washed their hands for 30 seconds, rinsed with tap water for 30 seconds, drained the water sufficiently, and finished handwashing. After handwashing, the ATP luminescence amount (RLU1) after handwashing of each panelist was measured in the same manner as above. Using the measured values of the ATP luminescence amount (RLU0) before handwashing and the ATP luminescence amount (RLU1) after handwashing, the cleaning rate by handwashing was calculated according to the following (Formula 1), the average value of the cleaning rates of 10 panelists was obtained, and the detergency was evaluated according to the evaluation criteria described below. (Formula 1) Cleaning rate (%) = 100 - RLU1 / RLU0 × 100 ····· (1)

[0065] <Evaluation Criteria> ◎: The cleaning rate is 90% or more. ○: The cleaning rate is 75% or more and less than 90%. △: The cleaning rate is 60% or more and less than 75%. ×: The cleaning rate is less than 60. It was determined that △, ○, and ◎ are practical.

[0066] ※2: Bactericidal power test against general bacteria <Test bacteria> As test bacteria, Escherichia coli (Escherichia coli NBRC3972) and Staphylococcus aureus (Staphylococcus aureus NBRC12732) were used. Each test bacterium was spread on an SCD agar medium (manufactured by Eiken Chemical Co., Ltd.), cultured at 37°C for 24 hours, the colonies were scraped off, and each was diluted in sterilized phosphate buffered saline and used as a bacterial suspension. <Test method> To 10 mL of each liquid detergent composition, 0.1 mL of each bacterial suspension was added so that the final concentration was 1.5 - 5.0×10 8 (CFU / mL), and after contacting at 25°C for 15 seconds, a sterilized neutralizing solution (SCDLP medium, manufactured by Eiken Chemical Co., Ltd.) was added and stirred well to obtain a test solution. Also, assuming organic soil, to 10 mL of each liquid detergent composition containing 0.1 mass% of yeast extract as soil, 0.1 mL of each bacterial suspension was added so that the final concentration was 1.5 - 5.0×10 8 (CFU / mL), and after contacting at 25°C for 30 seconds, a sterilized neutralizing solution (SCDLP medium, manufactured by Eiken Chemical Co., Ltd.) was added and stirred well to obtain a test solution. 1 mL of these was mixed and solidified on an SCD agar medium and cultured at 37°C for 2 days. After culturing, the viable cell count was measured, and the logarithmic reduction value (Log reduction value) was determined from the difference from the initial bacterial count, and the bactericidal power was evaluated according to the following criteria.

[0067] <Evaluation criteria> 1 point: A reduction in the number of bacteria with a Log reduction of the test bacterium of 5 or more 2 points: A reduction in the number of bacteria with a Log reduction of the test bacterium of 3 or more and less than 5 3 points: A reduction in the number of bacteria with a Log reduction of the test bacterium of 1 or more and less than 3 4 points: A reduction in the number of bacteria with a Log reduction of the test bacterium of less than 1 The reduction in the number of bacteria for each bacterial species was evaluated in points.

[0068] The average value of the scores of the above evaluations for the two types of bacteria was determined, and the bactericidal power was evaluated according to the following criteria. ◎: The average value is 1.0 point or more and less than 1.5 points. 〇: The average value is 1.5 points or more and less than 2.5 points. △: The average value is 2.5 points or more and less than 3.5 points. ×: The average value is 3.5 or more. And △, ○, and ◎ were determined to be practical.

[0069] ※3: Virus inactivation test <Test method> To 0.9 mL of each liquid detergent composition in a test tube, 0.1 mL of a virus solution adjusted to 10 8 TCID 50 / mL for each of the following 3 types of viruses was added, and the mixture was mixed with a mixer to prepare a mixed solution, which was allowed to act at 25 °C for 30 seconds. Also, assuming organic soil, to 0.9 mL of each liquid detergent composition in a test tube, 0.1 mL of a virus solution containing 5% meat extract (manufactured by Nacalai Tesque) adjusted to 10 8 TCID 50 / mL for each of the following 3 types of viruses was added, and the mixture was mixed with a mixer to prepare a mixed solution, which was allowed to act at 25 °C for 30 seconds. After the action, 0.1 mL of the above mixed solution was sampled and added to 9.9 mL of a reaction stop solution (cell growth solution containing 2% sodium thiosulfate, 0.2% lecithin, and 1.5% polysorbate 80), diluted 100-fold, and the action of various extracts on the virus was stopped. This was used as a sample stock solution for measuring the virus infectivity titer for measuring the infectivity titer. Similarly, a test using phosphate buffered saline (hereinafter sometimes abbreviated as PBS) instead of the extract was carried out as a control. Incidentally, phosphate buffered saline was prepared by mixing 4 types of salts, 8 g of sodium chloride, 0.2 g of potassium chloride, 1.44 g of disodium hydrogen phosphate, and 0.24 g of potassium dihydrogen phosphate, dissolving in 900 mL with ultrapure water, adjusting the pH to 7.4 with hydrochloric acid, and then making up to 1 L and sterilizing by autoclave.

[0070] In the above test, 3 types of viruses, feline calicivirus, murine norovirus, and influenza virus, were used as the virus. Each sample stock solution for measuring the virus infectivity titer was diluted 10 times with PBS8 After preparing a dilution by performing a ten-fold serial dilution up to this point, 50 μL each of the undiluted sample for measuring the infectious titer and the dilutions at each dilution step, and 50 μL of a cell suspension suspended in Dulbecco's modified Eagle's Medium (DMEM) containing 5% fetal bovine serum (FBS) were seeded into a 96-well plate. Then, the plate was cultured for 4 days at 37 °C and 5% CO2 in a carbon dioxide incubator. After culturing, the presence or absence of CPE (cytopathic effect) due to virus growth was observed under an inverted microscope, and the virus infectious titer (TCID 50 / mL) was determined using the Reed-Muench method and evaluated according to the following criteria.

[0071] <Evaluation Criteria> 1 point: A decrease in the Log reduction of the virus infectious titer of 4 or more 2 points: A decrease in the Log reduction of the virus infectious titer of 3 or more and less than 4 3 points: A decrease in the Log reduction of the virus infectious titer of 2 or more and less than 3 4 points: A decrease in the Log reduction of the virus infectious titer of less than 1 The decrease in the virus infectious titer for each virus was evaluated in points, and the average value of the points for the three viruses was determined. The virus inactivation effect was evaluated according to the following criteria.

[0072] ◎: The average value is 1.0 point or more and less than 1.5 points. 〇: The average value is 1.5 points or more and less than 2.5 points. △: The average value is 2.5 points or more and less than 3.5 points. ×: The average value is 3.5 or more. And △, 〇, and ◎ were determined to be practical.

[0073] ※4: Foaming test <Test method> This test was conducted by the Ross-Miles method (JIS K 3362). Each liquid detergent composition was foamed at 25°C, and the foam height at the start of measurement and after 5 minutes was measured. The foam retention rate was calculated according to the following formula (2) from the foam height (F1) after 5 minutes with respect to the foam height (F0) at the start of measurement, and the foam retention was evaluated according to the following criteria. A commercially available foam pump was used for foaming the liquid detergent composition. (Formula 2) Foam retention rate (%) = F1 / F0 × 100 ····· (2)

[0074] <Evaluation criteria> 〇: The foam retention rate is 90% or more. △: The foam retention rate is 80% or more and less than 90%. ×: The foam retention rate is less than 80%, or sufficient foaming cannot be obtained. And △ and ○ were determined to be practical.

[0075] ※5: Rinsability test <Test method> This test was conducted on 10 panelists who had received training on the evaluation of rinsability. Each panelist took 1 push (about 1 mL) of each liquid detergent composition placed in a commercially available foam pump, washed their hands for 30 seconds, then rinsed with tap water for 30 seconds, and evaluated the rinsability according to the following criteria based on the speed of rinsing and the lack of stickiness on the hands after rinsing.

[0076] <Evaluation criteria> 4 points: Good rinsability 3 points: Slightly good rinsability 2 points: Slightly poor rinsability 1 point: Poor rinsability The rinsability was evaluated by points and the average value was obtained, and the rinsability was evaluated according to the following criteria.

[0077] ◎: The average value is 3.4 points or more. 〇: The average value is 2.7 points or more and less than 3.4 points. △: The average value is 2.0 points or more and less than 2.7 points. ×: The average value is less than 2.0 points. And △, ○, and ◎ were determined to be practical.

[0078] ※6: Skin irritation test <Test method> This test was conducted on 10 panelists for each example. The panelists in this test did not conduct the detergency test, rinsability test, and skin irritation test of the liquid detergent compositions described in other examples during the test. Each panelist took 1 mL of the liquid detergent composition in their hand and washed their hands for 30 seconds, then rinsed their hands with tap water for 30 seconds. This hand-washing operation was repeated 3 times a day for 7 days. The skin irritation was evaluated based on the following criteria from the condition of each panelist's hands after 7 days.

[0079] <Evaluation criteria> 4 points: No roughness of the hands at all 3 points: Slight roughness of the hands can be seen 2 points: Roughness of the hands can be seen here and there 1 point: Considerable roughness of the hands can be seen The skin irritation was evaluated by scores and the average value was obtained, and the skin irritation was evaluated based on the following criteria.

[0080] ◎: The average value is 3.5 points or more. 〇: The average value is 3.0 points or more and less than 3.5 points. △: The average value is 2.5 points or more and less than 3.0 points. ×: The average value is less than 2.5 points. It was determined that △, 〇, and ◎ are practical.

[0081] ※7: Storage stability test <Test method>

[0082] 200 mL of each liquid detergent composition was taken in a 250 mL transparent polypropylene container, covered, and stored in a constant temperature bath at -5°C, 25°C, and 40°C and left standing. After 1 month, the appearance was observed.

[0083] <Evaluation criteria> 〇: No separation or turbidity is seen and it is stable. △: There is no overall separation, and slight turbidity is seen, but there is no problem in use. ×: Separation or turbidity is seen. and determined that △ and ○ are practical.

[0084] [Table 1]

[0085] [Table 2]

[0086] [Table 3]

[0087] [Table 4]

[0088] [Table 5]

[0089] [Table 6]

[0090] [Table 7]

Claims

1. An alkyltrimethylammonium salt as the (A-α) component, an alkyldimethylbenzylammonium salt as the (A-β) component, a pH adjuster composed of a combination of an alkali metal hydroxide and / or an alkanolamine and at least one selected from alkali metal carbonates, alkali metal phosphates, and organic acid salts as the (B) component, at least one selected from nonionic surfactants and amphoteric surfactants in an amount of 0.1% by mass or more and 6% by mass or less as the (C) component, a polyhydric alcohol which is at least one selected from the group consisting of ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,4-butanediol, 1,5-pentanediol, hexylene glycol, glycerin, polyglycerin, and sorbitol as the (D) component water as the (E) component, A liquid alkaline detergent composition for skin, containing the above components, wherein the total amount of the (A-α) component and the (A-β) component is 0.06% by mass or more and 0.5% by mass or less, the value of the mass ratio (A-α) / (A-β) of the mass of the (A-α) component to the mass of the (A-β) component is 0.06 or more and 0.75 or less, and the pH at 25°C is 8.0 or more and 12.0 or less.

2. The liquid alkaline detergent composition for skin according to Claim 1, wherein the value of the mass ratio (C component) / (A component) of the mass of the (C) component to the mass of the (A) component is 0.1 or more and 150 or less.

3. The liquid alkaline detergent composition for skin according to Claim 1 or 2, containing at least one selected from polyoxyalkylene alkyl ethers, alkyl glucosides including alkyl polyglucosides, alkyl betaine-type amphoteric surfactants, alkyl imidazolinium betaine-type amphoteric surfactants, alkylamino (mono- or di-) propionates, and alkyldimethylamine oxides as the (C) component.

4. The liquid alkaline detergent composition for skin according to Claim 1 or 2, containing at least one selected from ethylene glycol, polyethylene glycol, propylene glycol, butylene glycol, 1,5-pentanediol, hexylene glycol, glycerin, and sorbitol as the (D) component.

5. The alkaline liquid skin cleanser composition according to claim 1 or 2, wherein the alkaline liquid skin cleanser composition is a liquid cleanser for fingers.

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