Method for producing a fine current-forming liquid crystal nanoemulsion

Abstract

To provide a method of preparing a liquid crystal nanoemulsion that can exhibit beneficial effects of increasing skin absorption of active substances and improving skin elasticity.SOLUTION: A method of preparing a microcurrent-forming liquid crystal nanoemulsion includes: a step (a) of primarily mixing a phase A with a phase B (a); and a step (b) of adding a phase C to a mixture after the primary mixing of the step (a), and secondarily mixing the mixture, wherein the phase A is a mixture of oil, polyol, phospholipid, and an emulsifier, the phase B is a mixture of purified water, and an acrylic thicker or a gum-based thicker that imparts conductivity to a solution in which the thickener is dissolved in purified water, and the phase C is a mixture of purified water, and an organic acid or an organic acid salt that imparts conductivity to a solution in which the organic acid or organic acid salt is dissolved in purified water.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a method for manufacturing a fine current-forming liquid crystal nanoemulsion. Specifically, by enhancing electrical conductivity, better forming a voltage, and thus forming a higher fine current, the present invention relates to a method for manufacturing a liquid crystal nanoemulsion that can exhibit beneficial effects such as increased skin absorption of active substances and enhanced skin elasticity.

Background Art

[0002] For many years, it has been reported that a fine current has beneficial functionality that exerts effects on wound healing, cell activity, skin tone improvement, skin elasticity, and the like. Therefore, the beauty device market utilizing this has been steadily growing in recent years. However, beauty devices are expensive and have the disadvantages of being inconvenient to use and carry. Therefore, there is a demand for developing a cosmetic in the form of a composition that can generate a fine current without using a beauty device.

[0003] In recent years, when consumers use cosmetics, there have been efforts to apply the concept of piezoelectricity (a phenomenon in which a fine current or voltage is generated by polarization when pressure is applied), which is based on usage methods such as tapping after application to the skin or rubbing in by applying pressure to the skin, to cosmetics. That is, research has been conducted on a method for generating a fine current in which a fine current is formed when pressure is applied during application.

[0004] However, applying pressure as described above requires consumers to expend another effort of generating pressure. Therefore, the development of a new technology that can directly generate a fine current to better deliver active ingredients to the skin layer, enhance the absorption power, and exhibit beneficial skin functionality (such as enhanced elasticity and strengthened skin barrier) by the fine current is desired.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0006] The present invention develops and provides a method for manufacturing a liquid crystal nanoemulsion that can exhibit beneficial effects such as increased skin absorption of active substances and enhanced skin elasticity by further enhancing electrical conductivity, better forming voltage, and higher forming fine current.

Means for Solving the Problems

[0007] The present invention includes the steps of: (a) primary mixing of the following Phase A and Phase B; and (b) secondary mixing by adding the following Phase C after the primary mixing in step (a). Phase A is a mixture of oil, polyol, phospholipid, and emulsifier. Phase B is a mixture of purified water and an acrylic-based thickener or gum-based thickener that imparts conductivity to the solution when dissolved in purified water. Phase C is a mixture of purified water and an organic acid or organic acid salt that imparts conductivity to the solution when dissolved in purified water. A method for manufacturing a fine current-forming liquid crystal nanoemulsion is provided, characterized by the above.

[0008] In the method for manufacturing a fine current-forming liquid crystal nanoemulsion of the present invention, Phase B is preferably a mixture added with Phase D in which purified water and a neutralizer are mixed.

[0009] In the method for manufacturing a fine current-forming liquid crystal nanoemulsion of the present invention, Phase C is preferably a mixture further mixed with an amino acid.

[0010] In the method for manufacturing a fine current-forming liquid crystal nanoemulsion of the present invention, the polyol is preferably any one or more selected from octyldodecanol and glycerol.

[0011] In the method for producing a fine current-forming liquid crystal nanoemulsion of the present invention, the phospholipid is preferably any one or more selected from Phytosphingosine and Hydrogenated Lecithin.

[0012] In the method for producing a fine current-forming liquid crystal nanoemulsion of the present invention, the emulsifier is preferably any one or more selected from polyglyceryl-based emulsifiers and Sorbitan Olivate.

Effects of the Invention

[0013] By using the present invention, a nanoemulsion having a liquid crystal lamellar structure can be produced. Further, due to the interaction between the nano-sized liquid crystal structure and the electrolyte, the electrical conductivity can be further enhanced, the voltage can be better formed, and the role of a chemical battery can be better fulfilled.

[0014] The high-penetration nano-sized emulsion of the present invention is judged to form a higher fine current and maximize beneficial effects such as an increase in the absorption of active substances and an improvement in skin elasticity.

Brief Description of the Drawings

[0015]

Figure 1

Figure 2

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Figure 5

Figure 6

Modes for Carrying Out the Invention

[0016] In the present invention, when a thickening agent is used and polyol and organic acid are appropriately combined to produce a liquid crystal nanoemulsion, it has been confirmed that the electrical conductivity increases, a high voltage is formed, and by acting as a chemical battery, a fine current is highly formed in the dosage form itself without applying pressure to the skin. That is, when a liquid crystal emulsion having a lamellar structure is generated in nano units, the overall surface area becomes wider and the charge potential becomes higher. Therefore, the charge interaction with the electrolyte becomes higher than that of a general emulsion or a liquid crystal emulsion.

[0017] Specifically, the present invention includes the step (a) of primarily mixing the following Phase A and Phase B; and the step (b) of secondarily mixing by adding the following Phase C after the primary mixing in the step (a). The Phase A is a mixture of oil, polyol, phospholipid, and an emulsifier. The Phase B is a mixture of purified water and an acrylic-based thickening agent or a gum-based thickening agent that makes the solution conductive when dissolved in purified water. The Phase C is a mixture of purified water and an organic acid or an organic acid salt that makes the solution conductive when dissolved in purified water. A method for producing a fine current-forming liquid crystal nanoemulsion is provided. FIG. 1 is a schematic diagram showing the method for producing a fine current-forming liquid crystal nanoemulsion of the present invention.

[0018] Hereinafter, the method for producing a fine current-forming liquid crystal nanoemulsion of the present invention will be described in detail for each step.

[0019] <Step (a): Primary mixing of Phase A and Phase B> This step (a) is a process of mixing Phase A and Phase B. Phase A is a mixture of oil, polyol, phospholipid, and an emulsifier.

[0020] The oil is not particularly limited as long as it is widely used in cosmetics. Any oil that can be classified as such, such as fatty acids or ester oils, can be used, and it is preferably added at 0.1 to 30% (w / w) based on the total composition. As a specific example of the oil, Caprylic / Capric triglyceride can be used.

[0021] Polyol refers to an organic compound containing a plurality of hydroxyl groups. Representative examples thereof include glycerol, dipropylene glycol, pentylene glycol, propylene glycol, diglycerin, propanediol, methylpropanediol, and butylene glycol. In the present invention, it is preferably added at 0.1 to 20% (w / w) based on the total composition. In the present invention, it is not limited to a specific polyol, and one or more polyols can be mixed and used. As an example, Octyldodecanol and Glycerol can be mixed and used.

[0022] Phospholipid is a type of lipid containing a polar phosphate and a non-polar fatty acid, and is a major component of biological membranes. Since phospholipids have amphiphilic properties, in an aqueous solution environment such as water, the hydrophobic fatty acid portions aggregate to form a stable micelle or liposome structure. In the present invention, it is not limited to a specific phospholipid, and one or more phospholipids can be mixed and used. In the present invention, phospholipids are preferably added at 0.01 to 5% (w / w) based on the total composition. As an example, Phytosphingosine and Hydrogenated Lecithin can be mixed and used.

[0023] The emulsifier is not limited to specific ones, and one or more kinds of emulsifiers can be mixed and used. Preferably, it is good to mix and use sorbitan olivate and a polyglyceryl-based emulsifier. In the present invention, it is preferably added in an amount of 0.1 to 20% (w / w) based on the total composition.

[0024] Examples of the polyglyceryl-based emulsifier include polyglyceryl-4 caprate, polyglyceryl-3 polyricinoleate, diisostearoyl polyglyceryl-3 dimer dilinoleate, polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, polyglyceryl-10 oleate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 polyricinoleate, polyglyceryl-3 oleate, polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-3 diisostearate, polyglyceryl-10 dioleate, polyglyceryl-10 decaisostearate, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 stearate, polyglyceryl-2 isostearate / dimer dilinoleate copolymer, polyglyceryl-2 stearate, polyglyceryl-2 triisostearate, polyglyceryl-3 caprate, polyglyceryl-3 methyl glucose distearate, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, polyglyceryl-3 stearate, polyglyceryl-4 isostearate, polyglyceryl-5 oleate, polyglyceryl-8 decabehenate / caprate, polyglyceryl-4 oleate, polyglyceryl-6 distearate, polyglyceryl-3 beeswax, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polyglyceryl-10 distearate, polyglyceryl-3 distearate, polyglyceryl-4 laurate, polyglyceryl-6 laurate, polyglyceryl-3 ricinoleate, polyglyceryl-3 cocoate, and the like.

[0025] On the one hand, the B phase is a mixture of purified water and an acrylic-based thickener or a gum-based thickener that renders the solution conductive when dissolved in purified water. In the present invention, by adding a thickener, in addition to the thickening effect, it was confirmed that the nanoparticles were separated and the emulsification was enhanced. Further, an acrylic-based thickener or a gum-based thickener becomes conductive when dissolved in purified water. Therefore, in the liquid crystal nanoemulsion of the present invention, it was confirmed that by increasing the electrical conductivity and forming a voltage better, it can function better as a chemical battery. The thickener is preferably added at 0.01 to 2.00% (w / w) based on the total composition in the present invention.

[0026] For some thickeners, a neutralizer needs to be added for pH adjustment and viscosity improvement. However, after preparing a separate D phase by mixing purified water and a neutralizer, it can be added to the B phase and used. Examples of neutralizers include tromethamine, L-arginine, TEA (triethanolamine), etc. The neutralizer is preferably added at 0.01 to 2.00% (w / w) based on the total composition in the present invention.

[0027] <Step (b): After the primary mixing, add the C phase for secondary mixing> This step (b) is a process of adding the C phase for secondary mixing after the primary mixing in the above step (a).

[0028] Phase C is a mixture of purified water and an organic acid or organic acid salt that, when dissolved in purified water, makes the solution conductive. When the organic acid or organic acid salt is dissolved in purified water, it dissociates to form an electrolyte solution. Phase C, which has thus become an electrolyte solution, forms a voltage and enhances electrical conductivity. The organic acid or organic acid salt is preferably added in an amount of 0.01 to 5% (w / w) based on the total composition in the present invention. The organic acid or organic acid salt is not limited to specific ones, and one or more kinds can be mixed and used. As an example of the organic acid, citric acid can be used, and as an example of the organic acid salt, sodium citrate can be used.

[0029] On the other hand, preferably, Phase C further contains an amino acid. The amino acid is preferably added in an amount of 0.01 to 5% (w / w) based on the total composition in the present invention. The amino acid has a charge and helps to further enhance the electrical conductivity and better form a voltage within the liquid crystal nanoemulsion of the present invention. As an example of the amino acid, betaine can be used. Further, a preservative may be added to Phase C as needed. The type of preservative is not limited to specific ones, and one or more kinds can be mixed and used. Examples thereof include 1,2 - hexanediol and ethylhexylglycerine.

[0030] The manufacturing process of the fine - current - forming liquid crystal nanoemulsion of the present invention is as follows. First, Phase A and Phase C are each heated and then cooled for preparation. Then, Phase B (or "Phase B added with Phase D") is added to Phase A and stirred first - stage, preferably with a homomixer. Then, Phase C is added little by little while stirring second - stage, preferably with a homomixer.

[0031] The liquid crystal nanoemulsion of the present invention produced by the manufacturing method as described above has excellent electrical conductivity and can well form a fine current. Due to the galvanic effect, it can increase skin absorption by ionization of active substances in the cosmetic composition, and can exert the effects of enhancing skin elasticity and strengthening the skin barrier by the fine current itself. Therefore, the liquid crystal nanoemulsion produced by the method of the present invention can be added to cosmetic compositions or cosmetics in various dosage forms and used.

[0032] Hereinafter, the content of the present invention will be described in more detail using the following examples and experimental examples. However, the scope of the rights of the present invention is not limited to the following examples and experimental examples, and also includes the scope of technical ideas equivalent thereto.

[0033] [Example: Production of Fine Current Forming Liquid Crystal Nanoemulsion of the Present Invention] In this example, various examples with different thickeners were produced based on oil to compare the ability to form a fine current. As the oil, caprylic / capric triglyceride, which is typically used in cosmetics, was selected. The thickeners were selected from acrylic thickeners and natural gums that can provide particle emulsion stability and trap particles.

[0034] In Table 1 below, Phase A is an oil phase to which an emulsifier is added. Caprylic / capric triglyceride was used as the oil, octyldodecanol and glycerol were used as the polyol, sorbitan olivate and polyglyceryl-4 laurate, which is a polyglyceryl-based emulsifier, were used as the emulsifiers, and phytosphingosine and hydrogenated lecithin were used as the phospholipids.

[0035] The B phase is the thickener phase. In this example, various thickeners were composed in different ways for each example as described in Table 1 below, dissolved in purified water, and used.

[0036] The C phase is the aqueous phase, and an organic acid or organic acid salt that makes the solution conductive when dissolved in purified water is dissolved in the C phase. Citric acid was used as the organic acid, and Sodium Citrate was used as the organic acid salt. Also, Betaine was added and used as the amino acid, and a preservative was also added.

[0037] The D phase is the aqueous phase, but it is an aqueous solution to which a neutralizer is added. When Acrylates / C10-30 Alkyl and Polyacylic Acid were used as the thickeners, the D phase was added to the thickener phase and used. Tromethamine was used as the neutralizer.

[0038] The manufacturing process of the fine current-forming liquid crystal nanoemulsion of the present invention is as follows. First, the A phase and the C phase were each heated (85 °C) and then cooled (30 °C or lower) and prepared. Then, the B phase or "the B phase to which the D phase is added" was added to the A phase, and it was stirred with a homomixer for about 5 to 10 minutes. Then, while adding the C phase little by little, it was stirred with a homomixer for about 10 minutes.

[0039]

Table 1

[0040] [Experimental Example 1: Transmission Electron Microscope Observation of Examples] In the examples manufactured above, in order to confirm whether the liquid crystal lamellar structure and the nano-sized emulsion were well formed, the overall distribution was observed from the morphological aspect using a transmission electron microscope (TEM).

[0041] The results are shown in Fig. 2. It can be seen that in all examples, a lamellar film structure and particles with a size of about 2 to 300 nm are uniformly distributed generally.

[0042] [Experimental Example 2: Polarizing Microscopic Observation of Examples] For the examples, using a polarizing microscope among optical microscopes, it was observed whether a bright and shiny lamellar multilayer structure was formed.

[0043] The results are shown in Fig. 3. In all examples, bright and shiny crystal-shaped particles, which are characteristics of the multilayer lamellar structure, were observed.

[0044] [Experimental Example 3: Confirmation of Electrostatic Potential of Examples] To confirm the electrostatic potential, the zeta potential was measured for the examples.

[0045] The experimental results are shown in Fig. 4. In all examples, a zeta potential of -30 or less was recorded, and those with a recorded "zeta potential per particle" of -50 or less were also confirmed. On the other hand, as a control group, when measuring the zeta potential for an existing galvanic cream (Republic of Korea Patent Registration Bulletin No. 10-2559008), it was observed that although a value of -30 or less was recorded, it did not exceed -50.

[0046] Generally, when the absolute value of the zeta potential is recorded as -30 or less, it can be said that the repulsive force of the zeta potential is stable, and when the absolute value is -50 or less, it can be regarded as having a greater electrostatic repulsive force.

[0047] In the existing galvanic cream (Republic of Korea Patent Registration Bulletin No. 10-2559008), it does not exceed -50, but it can be seen that all of the present examples exceed it. In particular, in Examples 5 and 9, it was found that the distribution reaches up to -100.

[0048] Therefore, all of the present examples have excellent electrostatic repulsive forces, and in particular, Examples 5 and 9 were found to be the most excellent.

[0049] [Experimental Example 4: Measurement of Current and Voltage in Examples] To compare the actual current and voltage, the current and voltage of the examples and the control groups were measured comparatively (Table 2). As the control group 1, an existing galvanic cream (Korean Patent Registration Bulletin No. 10-2559008) was used, and as the control group 2, the current and voltage were measured using a galvanic product of another company.

[0050]

Table 2

[0051] As can be seen in Table 2 above, it was confirmed that both the current and voltage of the examples were overwhelmingly higher compared to the control group 1 and the control group 2. In particular, it was found that Examples 5 and 9 were excellent.

[0052] [Experimental Example 5: Measurement of Skin Electrical Conductivity in Examples] To measure the skin electrical conductivity of the examples, the electrical conductivity was measured after application to the skin. As the control groups, distilled water, a control group (general cream), and a control group 2 (the galvanic cream of Korean Patent Registration Bulletin No. 10-2559008) were adopted and the electrical conductivity was measured together.

[0053] The experimental results are shown in Figure 5. It was confirmed that all examples had higher electrical conductivity compared to the control groups, and in particular, it was confirmed that Examples 5 and 9 had the highest electrical conductivity.

[0054] [Experimental Example 6: Measurement of Light Emission of Light Emitting Diodes in Examples] When applying the examples to the light emitting diodes, it was confirmed whether they would light up when energized.

[0055] The experimental results are shown in Figure 6. It was observed that in all examples, the light emitting diodes lit up (red light was emitted from the light emitting diode bulbs) when applied.

Claims

1. Step (a) of primary mixing the following Phase A and Phase B; and, After the primary mixing in step (a), step (b) of adding the following Phase C and performing secondary mixing; including, The Phase A is a mixture of oil, polyol, phospholipid and emulsifier, The Phase B is a mixture of purified water and an acrylic-based thickener or gum-based thickener that makes the solution conductive when dissolved in purified water. The acrylic-based thickener is one or more selected from sodium polyacrylate, polyacrylamide, acrylate / C10-30 alkyl acrylate crosspolymer, polyacrylic acid, and ammonium acryloyldimethyltaurate / VP copolymer. The gum-based thickener is one or more selected from xanthan gum, diutan gum, ethylhexyl cellulose, and acacia gum, The Phase C is a mixture of purified water and an organic acid or organic acid salt that makes the solution conductive when dissolved in purified water, A method for manufacturing a microcurrent-forming liquid crystal nanoemulsion, characterized by the above.

2. The Phase B, A method for manufacturing a microcurrent-forming liquid crystal nanoemulsion according to claim 1, characterized in that a Phase D mixed with purified water and a neutralizer is added.

3. The Phase C, A method for manufacturing a microcurrent-forming liquid crystal nanoemulsion according to claim 1, characterized in that an amino acid is further mixed.

4. The polyol, A method for manufacturing a microcurrent-forming liquid crystal nanoemulsion according to claim 1, characterized in that it is any one or more selected from octyldodecanol and glycerol.

5. The phospholipid, A method for manufacturing a microcurrent-forming liquid crystal nanoemulsion according to claim 1, characterized in that it is any one or more selected from phytosphingosine and hydrogenated lecithin.

6. The emulsifier, It is one or more selected from polyglyceryl-based emulsifiers and sorbitan olivate, and the polyglyceryl-based emulsifier is polyglyceryl-4 caprate, polyglyceryl-3 polyricinoleate, diisostearoyl polyglyceryl-3 dimer dilinoleate, polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, polyglyceryl-10 oleate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 polyricinoleate, polyglyceryl-3 oleate, polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-3 diisostearate, polyglyceryl-10 dioleate, polyglyceryl-10 decaisostearate, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 stearate, polyglyceryl-2 isostearate / dimer dilinoleate copolymer, polyglyceryl-2 stearate, polyglyceryl-2 triisostearate, polyglyceryl-3 caprate, polyglyceryl-3 methyl glucose distearate, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, polyglyceryl-3 stearate, polyglyceryl-4 isostearate, polyglyceryl-5 oleate, polyglyceryl-8 decabehenate / caprate, polyglyceryl-4 oleate, polyglyceryl-6 distearate, polyglyceryl-3 beeswax, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polyglyceryl-10 distearate, polyglyceryl-3 distearate, polyglyceryl-4 laurate, polyglyceryl-6 laurate, polyglyceryl-3 ricinoleate, and polyglyceryl-3 cocoate, and is characterized by being 1 or more, the method for producing a fine current-forming liquid crystal nanoemulsion according to claim 1.

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