Two-liquid mixing device

Abstract

To provide a two-liquid mixing device where pumping mixing is performed in hands, assembly production cost is suppressed without assembling a main mixing structure part in a post-installation manner and mixing efficiency is excellent.SOLUTION: In a two-liquid mixing device completed by one component with a selected resin,: a mixing structure part acted with so-called two-liquid mixing action in a cylindrical device body and disposed in an inner cavity so as to divide a device inner cavity into two rooms integrally and continuously molds the device body or a connector body with a molding resin; the two-liquid mixing device can be completed with one molded component or two left and right connector molding components; and a complicated assembly work is not needed perfectly.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to a device that uses two injection syringes connected to both ends to pump and mix two different liquid solutions, such as two hydrophilic solutions, two hydrophobic solutions, or two different liquid solutions, such as a hydrophilic solution and a hydrophobic solution, or a slurry solution that efficiently and evenly disperses powder particles in the solution, in the hand. [Background technology]

[0002] Patent Documents 1 and 2 have been reported as prior art for emulsion preparation devices, and both have a structure in which a circular plate that forms minute gaps or minute holes that promote mixing of the two liquids is sandwiched between the left and right connectors near the center of the two connectors. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2013 / 133209 [Patent Document 2] Japanese Patent Application Laid-Open No. 2005-186026 Summary of the Invention [Problem to be solved by the invention]

[0004] Patent Documents 1 and 2 each describe a device configured by sandwiching a disk-shaped so-called mixing promotion mechanism between left and right connectors in separate work processes. In Patent Document 1, the disk-shaped mixing promotion mechanism fills the space between a first mesh and a second mesh with fibers to form a fiber aggregate, and thoroughly mixes the dispersed phase and the continuous phase through the gaps between the fibers that form the fiber aggregate. In Patent Document 2, the uniform fine pores in a disk-shaped porous body thoroughly mix the dispersed phase and the continuous phase.

[0005] As such, the so-called mixing promotion mechanisms related to the devices of Patent Documents 1 and 2 are mechanisms that sandwich a disk with a gap structure or a porous structure between the left and right connectors that are butted together, and therefore the mixing promotion mechanisms have an abutment surface or joint with the device body.

[0006] In devices with a structure in which the connectors on both sides are butted together, if the force used to butt and bond the connectors together is insufficient or if there are gaps in the bonded area around the entire perimeter, the device may bend and break at the bonded area, or liquid may leak from the gaps in the bond, exposing the person preparing the device to the solution at the time, which could cause serious problems.

[0007] In particular, when these devices are used in medical settings to prepare emulsion formulations required for patients, such as anti-cancer drug emulsions or vaccine emulsions, there is a risk of exposing the preparer to these highly toxic solutions and the cost of expensive pharmaceutical solutions is wasted.

[0008] In Patent Documents 1 and 2, when producing a W / O emulsion, the so-called porous structure including the disks is made of hydrophobic fibers or is subjected to a hydrophobic coating surface treatment with a silicone solution, so that the surface is easily wetted by the hydrophobicity of the continuous phase. In addition, in the case of an O / W emulsion, hydrophilic fibers are used, or the hydrophilic glass porous body is left as it is, and is equipped with a surface that is easily wetted by the hydrophilicity of the continuous phase.

[0009] Both Patent Documents 1 and 2 state that the disk, which is the so-called porous structure portion sandwiched between the connectors on both sides, must have a surface that is easily wetted by the continuous phase that constitutes the emulsion.

[0010] On the other hand, in both Patent Documents 1 and 2, the material of the inner lumen surface of the device that comes into contact with the two solutions that make up the emulsion is not considered important.

[0011] When preparing an emulsion, it is ideal for the surface inside the container to be one that is wettable by the continuous phase. For example, if the surface inside the container is made of a material that repels the continuous phase but is easily wetted by the dispersed phase, the dispersed phase particles that are neatly dispersed in the continuous phase will tend to adhere to the surface inside the container. This adhesion will continue, resulting in coarse dispersed phase particles, and the dispersed phase that forms the emulsion will pile up, resulting in emulsion demulsification (emulsion collapse) and phase separation.

[0012] The device in Patent Document 1 fills the space between the first and second meshes with fibers of a certain denier, and the gaps formed by the fibers allow the dispersed phase and continuous phase to mix well. The device also claims that the first and second meshes have numerous evenly arranged through-holes of the same area and have a large void ratio, although no specific numerical value is given.

[0013] However, in the device of Patent Document 1, even if a fiber with a hydrophobic surface property that repels the hydrophilic dispersed phase is used as the skeleton that forms the gaps that become the through-holes, there is a concern that a thin fibrous skeleton will not be able to achieve a sufficient mixing effect. While the mixing effect is essentially determined by the thickness of the skeleton, which is thick enough to interfere with pumping to some extent and cause tearing in order to finely disperse the dispersed phase, this is not considered important in Patent Document 1. Therefore, not only in the production of emulsions, but also in the mixing of two different liquid solutions, it is important to consider the skeleton line width relative to the gap width in order to ensure good mixing of the solutions.

[0014] For example, when mixing a heterogeneous mixture solution in a container with a stirring rod, a stirring rod with a small diameter will not mix efficiently. In other words, if the skeleton line width is narrow compared to the gap width, the dispersed phase will be torn apart by the skeleton and pass through the gap, but it will immediately recombine after passing through and will not be finely dispersed. In other words, it is thought that even if the number of pumping times is increased, fine dispersion will not be achieved easily.

[0015] Therefore, Patent Document 1 indicates that the fibers to be filled must have a certain length depending on the denier in order to be densely packed in a narrow space. However, the specification of Patent Document 1 clearly states in the examples that the desired emulsion cannot be produced when a thicker denier is used in the same space even though the same fiber length is used, making the selection difficult and cumbersome. In the first place, the assembly itself is cumbersome. [Means for solving the problem]

[0016] The present invention has been made in view of the above-mentioned problems, and aims to provide a manual pumping device which is completely free from the risk of breakage at the mating surfaces of the left and right sides or liquid leakage from the joints due to the pumping operation, and which can reliably produce the desired O / W emulsion or W / O emulsion without demulsifying the emulsion when preparing the emulsion.

[0017] Therefore, the device according to the present invention, which mixes different solutions by manual pumping using an injection syringe, has cylindrical connectors on the left and right sides each having a connection part connectable to an injection syringe, and one or two mixing structures each having an opening hole that serves as a through hole so as to roughly divide the device into two left and right chambers in the inner cavity of the device. Here, even if two mixing structures are provided, the two mixing structures are close to each other, and the third chamber formed between the two mixing structures is considered to be a passage chamber during liquid transfer. Therefore, even if two mixing structures are provided in the device inner cavity and the device is ultimately divided into three chambers, the passage chamber is ignored and the other two left and right chambers are expressed as being divided.

[0018] Furthermore, in the mixing structure provided in the device according to the present invention, the ratio of the opening area of ​​the opening hole to the entire surface of the mixing structure is preferably 30 to 70%, more preferably 40 to 60%. The device according to the present invention having the mixing structure provided with the opening hole can be easily realized by resin injection molding, resin stereolithography, or resin 3D printer molding. Furthermore, since the above molding methods have limitations in molding with fine holes, the diameter of the opening hole according to the present invention is preferably 0.5 mm or more.

[0019] If the aperture ratio of the opening holes is less than 30%, when manually pumping the two-liquid mixed solution simultaneously using the left and right injection syringes, a pressure load is placed on the hands, making the pumping operation difficult.On the other hand, if the aperture ratio is 70% or more, the skeleton width is narrow, and for example, the shear effect for tearing the dispersed phase is low, making it difficult to micronize the dispersed phase.

[0020] However, when the skeletal line width forming the opening hole is small, that is, when the opening ratio is 70% or more, and when the opening hole is deep in the length direction of the pumping flow, that is, when the mixing structure part is thick in the flow direction, a mixing effect can be obtained, so this method can be adopted under certain conditions.

[0021] In this case, the mixing effect can be achieved if the through-hole length in the flow direction is equal to or greater than the minor axis diameter that defines the hole area. For example, in the case of an elliptical opening, the mixing effect can be achieved if the through-hole has a through-hole length equal to the minor axis length that defines the ellipse. However, if the through-hole length is too long, a large amount of the mixed liquid remains in the device after the mixing operation is completed, which is not practical. Therefore, in this case, the through-hole length is preferably at most 5 times, more preferably up to 5 mm.

[0022] Here, mixing refers to an emulsion between a hydrophilic and a hydrophobic liquid, while it refers to dissolution between two hydrophilic or hydrophobic liquids. Even if the solutions are the same, if the viscosities are different, efficient and rapid mixing can be difficult. Examples include dissolving a viscous hydrophilic contrast agent in a fixed ratio with non-viscous water and physiological saline with a similar viscosity, dissolving vitamin solutions with intravenous fluids, dissolving different colored paints, emulsifying an oil-based contrast agent with an aqueous anticancer drug solution, or emulsifying an oil-based adjuvant solution with an aqueous nucleic acid solution.

[0023] In this case, if the volumes of each component are large, there is little concern about the mixed solution remaining in the device after mixing being wasted, but when mixing small amounts of valuable medicinal liquid, the remaining liquid volume is extremely wasteful. In consideration of these wasteful situations, the present invention, which can be used for a wide range of purposes, desirably has as small a volume as possible of the lumen filled with the liquid phase to be mixed when the syringe is attached.

[0024] The device of the present invention does not have a structure in which two connectors are butted together to sandwich or fit together a so-called mixing structure that promotes the mixing of two liquids, as in the aforementioned patent documents, but rather, as a result of extensive research, a practical device has been invented in which the mixing structure is integrally molded into the device body or connector body, which minimizes assembly and manufacturing costs and enables the device to fully demonstrate the mixing effect.In other words, it is an inexpensive device that can efficiently mix heterogeneous mixed solutions of two liquids, such as two hydrophilic solutions, two hydrophobic solutions, or a hydrophilic and a hydrophobic solution, slurry solutions in which powder particles are evenly dispersed in a solution, and even so-called S / O / W type emulsions in which a slurry solution in which fine powder particles are dispersed in oil is emulsified in an aqueous solution, and thus relates to the following devices. Item 1. A cylindrical resin device for mixing two liquids in two injection syringes on the left and right sides by pumping, wherein both edges of the device have connection parts that can be connected to the injection syringes, and a mixing structure part having one or more opening holes is provided so as to divide the inner cavity of the device into two chambers via the mixing structure part, and the mixing device is integrally molded with the device body by a series of resins without being fitted or joined as a separate part into the inner cavity of the device, and is formed as a single part. Item 2. A cylindrical resin device for mixing two liquids in two injection syringes on the left and right by pumping, said device being constructed by butting two cylindrical connectors together, one peripheral portion of said connector having a connection portion connectable to an injection syringe, and a mixing structure portion having one or more opening holes, which is provided so as to divide the inner cavity of one of said connectors into two chambers via said mixing structure portion, or to cover the outer peripheral portion of the other, and which is connected to one of said connector bodies by a series of resin and integrally molded without being fitted or joined as a separate part to the inner cavity of said connector, and two of said connectors with one mixing structure portion formed from one part are butted together with the opposite sides of said connecting portion facing each other to form a liquid-tight joint. Item 3. A mixing device according to any one of Items 1 and 2, wherein the mixing structure has 2 to 10 opening holes. Item 4. The hybrid device according to any one of items 1 to 3, wherein the opening hole has a shape other than a perfect circle. Item 5. The through length of the opening hole corresponds to the thickness of the mixing structure, and the through length has a length at least equivalent to the minor axis diameter of the cross section forming the opening hole. A mixing device described in any one of items 1 to 4. Item 6. A mixing device according to any one of items 1 to 5, characterized in that, among the opening holes provided in the mixing structure, some of the opening holes are formed by recesses in the inner surface of the device body and the outer edge of the mixing structure. Item 7. A mixing device according to any one of items 1 to 6, characterized in that the opening ratio of the opening holes provided in the mixing structure is 30% to 70% or less with respect to the area of ​​the mixing structure. Item 8. A mixing device according to any one of items 1 to 7, characterized in that the cross-sectional shape of the mixing structure part when viewing the device cavity from the side of the connection part for connecting an injection syringe is within a circle with a maximum diameter of φ3.9 mm. Item 9. A mixing device according to any one of items 1 to 8, characterized in that the opening areas of the one or more opening holes provided in one of the mixing structure portions have a difference of 120% to 300%. Item 10. A mixing device according to any one of items 1 to 9, characterized in that the mixing structure portion is connected to the connector body with a continuous resin at an installation position 7.5 mm to 12 mm from the connector edge portion where it tapers down, and is formed as a single part. Item 11. The mixing device according to any one of Items 1 to 10, wherein the molding resin is a hydrophobic resin. Item 12. A mixed device according to Item 11, wherein the hydrophobic resin for molding is a tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer resin or a tetrafluoroethylene-ethylene copolymer resin. Item 13. The mixing device according to any one of Items 1 to 10, wherein the molding resin is a hydrophilic resin. Item 14. The mixed device according to Item 13, wherein the hydrophilic resin for molding is a polyamide resin, or a polyethylene terephthalate resin, or an acrylic resin, or a vinyl chloride resin, or a polystyrene resin. Item 15. The mixing device according to any one of items 1 to 10, wherein the molding resin is a neutral resin. Item 16. The mixed device according to Item 15, wherein the molding neutral resin is a polyester resin, a polystyrene resin, a polypropylene resin, or a polyvinylidene fluoride resin. [Effects of the Invention]

[0025] According to the present invention, since the structure does not involve sandwiching a disk or mesh with fine holes between the left and right connectors as described above, there is no hassle in assembling these, and the manufacturing costs associated with this assembly work are eliminated, making it possible to provide the product at low cost.

[0026] The present invention is a mixing device with a completely new mechanism that takes pumping operability into consideration, has an integrated structure that is low cost and suitable for mass production, and has a mixing structure in the inner cavity of the device that is the result of extensive research and has the most effective structure for mixing effect. DETAILED DESCRIPTION OF THE INVENTION

[0027] Hereinafter, embodiments of the present invention will be described based on examples shown in the drawings, but it goes without saying that the present invention is not limited in any way to the contents of the following examples and explanations. [Example]

[0028] <Material> The device of the present invention is constructed as a single piece using resin molding such as injection molding, photolithography, or 3D printer molding, and the material selected must be a resin that meets the conditions for each molding, such as fluidity and moldability.

[0029] In the case of two hydrophilic solutions to be mixed, or in the case of an O / W emulsion in which the dispersed phase is hydrophobic and the continuous phase is hydrophilic, the lumen surface of the device of the present invention that comes into contact with the solution is desirably hydrophilic. Therefore, the material of the device of the present invention is desirably a resin that is relatively water-wettable, such as polyamide resin (PA) (water contact angle: 50°-80°), polyethylene terephthalate resin (PET) (water contact angle: 65°-80°), acrylic resin (PMMA) (water contact angle: 50°-70°), or vinyl chloride resin (PVC) (water contact angle: 60°-75°), which can be molded into resins with a water contact angle of 90° or less. Here, examples of vinyl chloride resins that can be used include acrylic-modified vinyl chloride resins, which are relatively water-wettable molding resins.

[0030] Furthermore, when the two liquid solutions to be mixed are both hydrophobic, or when a W / O emulsion is used in which the dispersed phase is hydrophilic and the continuous phase is hydrophobic, it is desirable that the lumen surface of the device of the present invention, which comes into contact with the solution, is hydrophobic. Therefore, it is desirable that the material for the device of the present invention be a resin that is relatively easily wetted by a hydrophobic solution, in other words, a resin that is difficult to wet with water. For example, tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer resin: PFA (contact angle with water: 110-120°) or tetrafluoroethylene-ethylene copolymer resin: ETFE (contact angle with water: 96-115°), which are resins that have a contact angle with water of 90° or more and are easy to mold, can be used.

[0031] Here, polytetrafluoroethylene resin (PTFE), known as Teflon, is a resin that is resistant to water wetting (contact angle with water: 110° to 120°), and is easily used as a resin for extrusion molding such as fibers and tubes. However, the molding conditions are extremely difficult to use as a resin for injection molding to form the device of the present invention, making it unrealistic.

[0032] In addition, polyester resin: PE (contact angle with water: 75° to 95°), polystyrene resin: PS (contact angle with water: 85° to 88°), polypropylene resin: PP (contact angle with water: 90° to 95°), and fluorine-based resin polyvinylidene fluoride resin: PVDF (contact angle with water: 80° to 90°) can be used as resins for injection molding, but as the material properties of these resins are not clear as to whether they are hydrophilic or hydrophobic and are close to neutral, they can be used for molding in the devices of the present invention, but their priority is low.

[0033] <Structure 1> The device of the present invention is completed in one part using a selected resin, and the mixing structure, which has a so-called two-liquid mixing action and is provided in the inner cavity of the cylindrical device body so as to divide the inner cavity of the device into two chambers, is formed continuously with the molded resin in the device body.In other words, because it is molded as a single unit, there is no need for any complicated assembly work to complete the device after molding.

[0034] More specifically, in the vicinity of the center of the lumen of the cylindrical device body g of the present invention as shown in FIG. 2, when the cylindrical direction of the device d is the axial direction x as shown in FIG. 1, there is the mixing structure s, which is a block wall having a certain thickness so as to interrupt the axial direction x and form two left and right chambers, and the block wall has an opening hole h connecting the two left and right chambers, and in terms of the opening hole, it is not possible to form a large number of micrometer-scale fine holes in the mold for molding, and further, considering that it is preferable that the pressure load of the device according to the present invention is small because it is pumped in the palm of one's hand, For the purpose of two-liquid mixing, a device with at most 2 to 10 submillimeter-scale openings (approximately 0.5 to 2 mm) is preferred. To minimize the amount of mixed solution remaining in the device cavity after the two-liquid mixing operation and to enhance the shear effect of the alternating left and right flow caused by the pumping operation, the surface diameter of the mixing structure s (i.e., the device cavity 5 shown in Figure 2) is preferably small to increase the flow rate. It should be within a diameter of φ3.9 mm. That is, the mixing structure s may be rectangular as long as it fits within a circle with a diameter of φ3.9 mm. Furthermore, as shown in Figure 2(a), it is desirable to form the mixing structure s at an installation position q between 7.5 mm and 12 mm, tapering from the connector edges w on both sides toward the center. Furthermore, the mixing structure s is molded as a continuous unit into the cylindrical device body g by molding using the resin according to the present invention.

[0035] <Structure 2> As shown in Figure 3(a), in the device according to the present invention, the inner cavity 5 of each of the cylindrical connectors d1 and d2 is connected as a continuous resin with a mixed structure section s1 having at most 2 to 10 opening holes, as explained above in Figure 2, and is integrally molded at an installation position q 7.5 to 12 mm away from the connector edge section w, tapered in a tapered manner, and the two connectors are butted together at the butt joint section c so as not to leak liquid, thereby forming the device d according to the present invention as shown in Figure 3(b).

[0036] In this case, the third chamber, the passage chamber 6, can be formed at the butt c portion of the two connectors, and when the device is used to mix two liquids by pumping, the mixed solution that flows from one chamber through the mixing structure s1 formed in the cavity 5 is further stirred in the passage chamber 6 and flows out through the mixing structure s1 of the other cavity 5 into the other chamber, and the mixing effect and the shear effect at the opening holes provided in both mixing structures s1 can be further enhanced. In this example, the formation of the connectors d1 and d2 can be designed so that the connector cavity does not have so-called forced molding locations on the left and right sides during injection molding, and can be realized by injection molding using the above-mentioned resin according to the present invention, and in this example, the device d according to the present invention can be formed from two parts.

[0037] In this case, if the openings formed in the two mixing structures s1 are misaligned in the x-axis direction, the liquid will not pass through in a straight line but will instead have a curved flow path, which will promote the mixing effect. The connectors d1 and d2 are identical molded parts, and by facing them on the x-axis and rotating them at a certain angle, the device d according to the present invention, in which the openings are misaligned, can be formed. In other words, by butting two identical molded parts together, the mixing device d according to the present invention can be realized, which can promote the mixing effect. As such, according to the present invention, a device can be realized that has a small number of parts and provides excellent mixing effect at extremely low manufacturing costs.

[0038] In this case, the two connectors can be butted together and fixed by an appropriate method such as ultrasonic welding, welding using an adhesive or a solvent, etc. The same applies to the following embodiments.

[0039] <Structure 3> As shown in Figure 3(c), in the device according to the present invention, a mixing structure portion s1 having at most 2 to 10 opening holes in the inner cavity 5 of each of the cylindrical connectors d1' and d2' is molded in a continuous resin connection, as explained in Figures 3(a) and 3(b). This is integrally molded at an installation position q 7.5 to 12 mm away from the edge portion w of each connector, where it tapers down, and is molded so as to cover the edge portion on the opposite side of the connection portions 3 and 4 of the cylindrical connectors with the injection syringes. By butting and joining the two connectors at the butt joint c so as not to leak liquid, the device d according to the present invention can be formed as shown in Figure 3(d).

[0040] At this time, the mixing structure s1 of the connector d1' and the mixing structure s1 of the connector d2' are abutted against each other, and the aforementioned passage chamber 6 is not formed at the butt joint c of the two connectors. The openings formed in both mixing structure s1 become a single through-hole. Therefore, if the arrangement of the openings is misaligned, the through-holes can be curved. Because the connectors d1' and d2' are identical molded parts, by facing each other on the x-axis, rotating them at a certain angle, and butting them together, the device d according to the present invention can be formed with misaligned openings. In other words, by butting two single molded parts together, the mixing device d according to the present invention can be realized, which can enhance the mixing effect.

[0041] <Structure 4> As shown in Figure 4(a), in the device according to the present invention, a funnel-shaped mixing structure s2 having at most 2 to 10 openings is integrally molded in the lumen 5 of each of the cylindrical connectors d3 and d4, as explained above in Figure 2, and this is integrally molded at an installation position q that is 7.5 to 12 mm away from the edge w of each connector, where it tapers down. When the funnel-shaped mixing structure provided in the device lumen 5 is viewed from the connection portion 3 or 4 with the injection syringe, the opposite side has a wide cross-sectional area, but the mixing structure s2 has a cross-sectional area that is at least equivalent to the lumen 5. By butting the two connectors together at the butt portion c and joining them liquid-tightly, the device d according to the present invention can be formed as shown in Figure 4(b).

[0042] At this time, a passage chamber 6 can be formed at the butt c portion of the two connectors, and when the device is used to mix two liquids by pumping, the mixed solution that flows from one chamber through the mixing structure s2 formed in the lumen 5 is further stirred in the passage chamber 6 and flows out into the other chamber through the mixing structure s2 of the other lumen 5, and the mixing effect can be further enhanced by this stirring effect and the shear effect at the opening holes provided in both mixing structures s2. The formation of the connectors d3 and d4 in this example can be designed so that the connector lumen portions do not have so-called forced molding locations on the left and right sides in injection molding, and can be realized by injection molding using the above-mentioned resin according to the present invention, and even in this example, the device d according to the present invention can be formed from two parts.

[0043] <Structure 5> As shown in Figure 4(c), in the device according to the present invention, a funnel-shaped mixing structure s2 having at most 2 to 10 openings in each of the inner cavities 5 of the cylindrical connectors d3' and d4' is molded in a continuous resin connection, as described above, and is integrally molded at an installation position q 7.5 to 12 mm away from the edge portion w of each connector, where it tapers in a tapered manner. Furthermore, the connection portions 3 and 4 of the cylindrical connectors with the injection syringes are molded so as to cover the edge portions on the opposite sides, and the two connectors are butted together at the butt joint c to prevent liquid leakage, thereby forming the device d according to the present invention, as shown in Figure 4(d).

[0044] At this time, the mixing structure s2 of the connector d3' and the mixing structure s2 of the connector d4' are abutted against each other, and the aforementioned passage chamber 6 is not formed at the butt joint c of the two connectors. The openings formed in both mixing structure s2 become a single through-hole. Therefore, if the arrangement of the openings is misaligned, the through-holes can be curved. Because the connectors d3' and d4' are identical molded parts, by facing each other on the x-axis, rotating them at a certain angle, and butting them together, the device d according to the present invention can be formed with misaligned openings. In other words, by butting two single molded parts together, the mixing device d according to the present invention can be realized, which can promote the mixing effect.

[0045] <Structure 6> As shown in Figure 5(a), the device according to the present invention has a mixing structure portion formed in the center of the lumen of the device d, which has a passage chamber 6 configured as shown in Figure 4(b) above. The center of the lumen of this example device is wider than the periphery of the lumen, making it impossible to form it using so-called injection molding. However, using the now widely used stereolithography technology and 3D printer technology, this example device can be easily formed as a so-called one-piece object in which molded resin is connected in a continuous series without the butt joint c as shown in Figure 4 using the resin according to the present invention described above.

[0046] Similarly, in the example shown in Figure 5(b), the center of the lumen is wider than the lumen periphery, which is impossible with injection molding. However, by using the above-mentioned techniques, it is possible to easily mold even so-called forced-out structures that are impossible with injection molding.

[0047] 5(a) and 5(b), the device according to the present invention is similar to the above-described examples in that it does not require the troublesome insertion or clamping of a component corresponding to the mixing structure as a separate component, as in Patent Documents 1 and 2. In this case, too, the device lumen 5 is preferably molded as a continuous piece to the device body, as in the above-described explanation of Figure 2, with a diameter of φ3.9 mm or less, and the number of opening holes being preferably 2 to 10 at most.

[0048] <Mixed structure part 1> As described above, the mixing structure according to the present invention is formed as a molded resin connected to the device body or one of the connector bodies, and the degree of opening of the opening holes provided therein is shown in Fig. 6, which is a simplified illustration. For example, if the opening rate is 70% or more (excluding 70%) as shown in Fig. 6(a), this means that the cross-sectional area of ​​the opening holes h is wide and the framework f forming the opening holes h is thin. In this example, as described above, this is the same as mixing with a thin stirring rod, and efficient mixing cannot be achieved. Also, if the opening rate is less than 30% as shown in Fig. 6(b), this means that the cross-sectional area of ​​the opening holes h is narrow and the framework f forming the opening holes h is thick. When manually pumping using the device, a pressure load is applied to pass through the opening holes, making the operation inefficient and unrealistic. In contrast, if the opening rate in Figure 6(c) is 30% to 70% (including 70%), in this case the skeleton f has a cross-sectional area equivalent to the cross-sectional area of ​​the opening hole h, and therefore the liquid supply blocking effect has the effect of breaking up the dispersed phase in the case of emulsions, and also produces a dispersion effect even in homogeneous and heterogeneous solutions, resulting in efficient mixing, and the pumping operation is an operation with less pressure load.

[0049] <Opening hole> The shape of the opening is preferably other than a perfect circle. For example, if the opening h1 of the device of the present invention is a perfect circle, as shown in Figure 7(a1) of one opening, when an emulsion is generated, as the dispersed phase leaves the opening h1, as shown in Figure 7(a2), the dispersed-phase particles Dp are connected to the circular outlet edge of the opening h1, which is the opening cylindrical body 7a connecting the two chambers, by a liquid contact line 8a. Therefore, like soap bubbles, they do not easily break away from the circular hole and instead coarsen in the direction of arrow v. This means that the dispersed-phase particles Dp will continue to coarsen as the flow u is sent, making them unsuitable for pumping emulsification, which aims to reduce the size of the particles.

[0050] In contrast, in the case of an elongated hole such as the opening h2 of the cylindrical opening 7b shown in FIG. 7(b1), as shown in FIG. 7(b2), the liquid contact between the dispersed-phase particles Dp attempting to leave the opening h2 and the rectangular outlet edge of the opening h2 is small, at liquid contact lines 8b and 9b, and so the dispersed-phase particles Dp cannot remain connected to the opening h2 for a long time and can quickly leave the opening h2. As a result, the dispersed-phase particles Dp are able to break up and disperse as fine particles without becoming coarse as the liquid is sent u.

[0051] Therefore, when considering the production of emulsions using the device of the present invention, the openings are preferably rectangular or elongated holes with corners that allow dispersed particles to easily escape. For example, shapes other than perfect circles, such as squares, rectangles, ovals, rhombuses, sectors, triangles, and gourds, are preferred.

[0052] The opening ratio of the area of ​​the open holes to the entire area of ​​the mixed structure having a maximum diameter of 3.9 mm is preferably 30 to 70%, more preferably 40 to 60%.

[0053] Furthermore, the size of the openings formed in the mixing structure does not necessarily have to be uniform, and it is actually better to have both large and small openings. This is because, when an emulsion is produced by pumping emulsification using the device of the present invention, the dispersed phase is in the form of coarse clumps in the continuous phase at the beginning of pumping, and is finely dispersed through the larger openings, which are easier to pass through for the coarse particles. With each pumping cycle, the dispersed particles gradually become smaller, and the smaller dispersed particles pass through the smaller openings and become even smaller, thereby achieving a gradually uniform dispersed particle structure.

[0054] In contrast, if many small openings are provided because they are suitable for the fragmentation of dispersed particles, especially when generating emulsions (emulsification), a material that repels the dispersed phase, as in Patent Documents 1 and 2, is used. This means that the initial pumping force required to pass the coarse dispersed phase is higher than that required for the continuous phase, making the pumping operation cumbersome. As a result, such devices are not adopted, particularly in busy medical settings where emulsion formulations are prepared immediately before use in front of patients. Therefore, it is most desirable to have a device that allows smooth pumping and allows preparation immediately without burdening the operator. When pumping with two injection syringes on both sides, if the area of ​​all openings is uniformly small, approximately 10%, a certain amount of pressure is inevitably required in the initial mixing of the dispersed phase and continuous phase, such as in emulsions, due to the coarse dispersed phase. This pressure gradually becomes lighter with repeated pumping. However, as the entire formulation becomes finer, the viscosity increases, as is well known, and the pressure becomes heavier due to the influence of viscosity. When there are many small openings, if the opening rate is high, the resistance felt when pumping is reduced, but if the opening rate is less than 30%, the load resistance increases even more.

[0055] Therefore, it is desirable that the openings provided in one mixing structure according to the present invention have different sizes, and it is desirable that there are openings with different sizes of 120% to 300%. The arrangement and ratio of the openings may be adjusted as appropriate.

[0056] Furthermore, with regard to the length (through length) of the opening hole provided in the one mixing structure part of the present invention that connects two chambers, it is desirable that the through length be equal to or greater than the minor axis diameter 11 of the opening hole cross section that forms the rectangular opening hole h3, as shown in Figures 8(a1)(b1)(c1).

[0057] For example, as shown in Figure 8(a1), when the dispersed phase Dr of an emulsion enters an opening h3 that is rectangular with a major axis diameter 10 and a minor axis diameter 11 and has a through-length 12a that is equal to or greater than the minor axis diameter 11, the dispersed phase Dr is broken down into dispersed phase particles Dp by the supply pressure within the through-length 12a of the opening h3, as shown in the side view 8(a2) of Figure 8(a1).

[0058] As shown in Figure 8(c1), if the dispersed phase Dr of an emulsion enters an opening h3 that is rectangular with a major axis diameter 10 and a minor axis diameter 11 and has a penetration length 12c that is shorter than the minor axis diameter 11, the dispersed phase Dr will pass through as it is without any room for the dispersed phase particles Dp to be broken down by the supply pressure within the penetration length 12c of the opening h3, as shown in the side view 8(c2) of Figure 8(c1).

[0059] Therefore, as shown in Figure 8(b1), the length (through length) of the opening hole in the present invention is a rectangle with a major axis diameter 10 and a minor axis diameter 11, and has a through length 12b at least equal to the minor axis diameter 11. When the dispersed phase Dr of the emulsion enters by the liquid supply u, the dispersed phase Dr can be broken down into dispersed phase particles Dp by the supply pressure within the through length 12b of the opening hole h3, as shown in the side view 8(b2) of Figure 8(b1).

[0060] In particular, as shown in Figure 9(a), when the fan-shaped opening holes h4 provided in the mixing structure s are close to each other, that is, when the skeletal width constituting the opening holes of the mixing structure is narrow and the opening rate of all opening holes relative to the entire surface of the mixing structure is 70% or more (excluding 70%), it becomes significantly difficult to refine the dispersed phase.Therefore, for the opening hole h4 having a major axis diameter 13a and a minor axis diameter 13b as shown in Figure 9(b), it is preferable that the through length 13c of the opening hole h4 shown in side view 9(c) be at least equal to the minor axis diameter 13b.

[0061] <Mixed structure part 2> 10(a), the mixing structure s provided in the lumen 5 of the device of the present invention is circular and follows the contour corresponding to the maximum diameter of the lumen φ3.9 mm. However, rather than being a disk with an outer ring, the mixing structure s has six equally spaced fan-shaped openings h6 formed in the lumen surface (the inner surface of the cylindrical device body) and the main body of the mixing structure s, with the outer edge of the circumference recessed in places, similar to the example in Figure 9. The mixing structure s is integrally molded and connected to the main body of the device d by molding resin. Because the openings h6 are recessed, the contact surface between the lumen 5 and the mixing structure s is minimal, and the mixing structure s will not come off the main body of the device d during pumping, allowing for safe mixing operations.

[0062] The opening area of ​​one of these holes h6 is 0.45 mm 2 The opening area of ​​the mixing structure s varies in the direction of the center. 2 Three opening holes h5 are provided at equal intervals in the circumferential direction. Here, the opening area ratio of one opening hole h6 to one opening hole h5 is approximately 121%, and the opening holes provided in the mixing structure s are composed of two types of opening holes with different opening areas, resulting in a mixing structure with opening holes of varying sizes. In this case, the penetration length of the opening holes h5 and h6, i.e., the thickness of the mixing structure s corresponding to 13c in Figure 9(c), is a length (not shown) corresponding to the minor axis diameter of the sectors (both of which are the same) that make up the opening holes h5 and h6, which is 0.5 mm.

[0063] The circular area of ​​the mixing structure portion provided in the maximum diameter of the inner cavity 5 is 3.9 mm. 2 The total area of ​​all openings is approximately 3.8 mm 2 The total opening rate, that is, the opening rate of the open holes of the mixing structure portion s, is about 32%.

[0064] <Mixed structure part 3> As shown in FIG. 10(b), instead of the opening hole h6 in FIG. 10(a), in this embodiment, three opening holes h7 are provided at equal intervals around the circumference, and each opening has an area of ​​0.89 mm 2 As in Figure 10(a), the opening area of ​​the mixing structure s varies in the direction of the center. 2 Three opening holes h5 are provided at equal intervals in the circumferential direction. The opening area ratio of one opening hole h7 to one opening hole h5 is approximately 243%, and the opening holes provided in the mixing structure are composed of two types of opening holes with different opening areas, resulting in a mixing structure of opening holes with a variation in opening area. The through length of the opening holes, that is, the thickness of the mixing structure corresponding to 13c in Figure 9(c), is a length (not shown) equivalent to the minor axis diameter of the sectors constituting the opening holes h5 and h7, which is 0.5 mm (the same for both).

[0065] Here, as in FIG. 10(a), the maximum diameter of the device lumen 5 is φ3.9 mm and the circular area is 11.9 mm 2 The total area of ​​all openings is approximately 3.8 mm 2 The total opening rate, that is, the opening rate of the open holes of the mixed structure portion s, is about 32%, which is the same as that in FIG. 10(a).

[0066] <Transparency> 10(a) and 10(b), even if the total opening rate of the openings provided in each mixing structure s is the same, approximately 32%, if the size of the openings provided is different between the two mixing structures, the pressing force passing through the mixing structure s will be different. To simplify this, Table 1 shows that using two porous bodies with the same opening rate of approximately 55%, the passing pressure differs depending on the pore size, which corresponds to the openings of the present invention.

[0067] 5 mL of water for injection was filled into a 5 cc syringe, and the pressure applied to the syringe plunger was measured when the solution was passed through an SPG pumping connector (SPG Techno Co., Ltd.) with a 50 μm pore size and a 100 μm pore size. The measurement was performed at a pressure speed of 2.5 cm / 3 seconds, and the average results of three runs are shown in Table 1.

[0068] [Table 1]

[0069] As shown in Table 1, even if the opening ratio (porosity) is the same, the larger the pore diameter, the lower the pressure required to pass through. In this way, even if the opening ratio is the same, a device with a mixing structure with larger opening holes h requires a lower pressure to pass through it, making it easier to pump.

[0070] Furthermore, to use the device of the present invention by manual pumping, a structure that imposes a small pressure load on the palm is preferred, although this depends on the capacity of the injection syringe used. To achieve this, the desired device can be formed by appropriately adjusting the aperture ratio, aperture shape, and penetration length of the openings in the mixing structure, which are factors that contribute to this. The mixing structure preferably has openings such that the pressure applied to the palm as a load during the pumping operation is less than 20 N for water if the molding resin of the present invention is a hydrophobic resin, or less than 10 N for kerosene if the molding resin is a hydrophilic resin, when the plunger of a 5 cc injection syringe is pressed at a pressing speed of 2.5 cm / 3 seconds.

[0071] <Bent Opening Hole> In one embodiment shown in Figure 11(a), the through path having an opening hole h3 provided in the mixing structure part of the present invention is bent as shown in Figure 11(d), in which the opening hole cylindrical body 7c and the opening hole cylindrical body 7d are formed in a state where they are offset in the direction of the z arrow, and a communication port k which serves as a gap is formed at the contact surface (broken line interface m) between the opening hole cylindrical body 7c and the opening hole cylindrical body 7d, and the device of the present invention connects two chambers on the left and right sides separated by the mixing structure part having this opening hole h3.

[0072] 8(a1) are abutted together while being shifted in the direction of the arrow z, and the through length 14a of this opening h3 can be seen as twice the through length 12a. However, since the rectangular hole that forms opening h3 has a major axis diameter 10 and a minor axis diameter 11, the through length 14a of this embodiment only needs to correspond to at least the length of the minor axis diameter 11, as described above.

[0073] In the device of the present invention having a mixing structure s in which the opening hole h3 of this embodiment structure is provided, when the dispersed phase Dr of the emulsion enters the opening hole h3 from one chamber in the liquid transfer direction u, it is broken down into dispersed phase droplets Dp, passes through the communication port k, and flows into the chamber on the opposite side.

[0074] Therefore, by adjusting the opening area of ​​the communication port k to be small, the dispersed-phase droplets Dp can be further refined. The communication port k has no thickness (penetration) length in the direction of the arrow x in Figure 11(a), and since the communication port k is an opening hole with no penetration length, there is no load resistance applied to the liquid transfer along the penetration length, which also contributes to reducing the pressing force of the pumping liquid transfer itself according to the present invention.

[0075] <Mixed structure part 4> One embodiment of the mixing structure s according to the present invention having the curved opening holes shown in Figure 11 is shown in Figure 12. This is formed by abutting two mixing structures having the opening holes of Figure 10(b) as s3 and s4 (opening holes not shown) in Figure 12(a), where the opening hole arrangement as viewed from the x1 arrow in Figure 12(a) is Figure 12(a1), and the opening hole arrangement as viewed from the x2 arrow is Figure 12(a2), and the opening hole arrangements are abutted with each other shifted at a certain angle in the rotational direction, so that the mixing structure s can be provided so that the two chambers are connected through the curved opening holes.

[0076] The opening holes connecting the two left and right chambers formed at this time have a curved through-path as shown in Fig. 11, and at the interface m shown by the dashed line where the cylindrical opening holes of the mixing structure s3 and the mixing structure s4 in Fig. 12(a) are misaligned and abut, a communication port k (shaded area) that has no thickness in the liquid feed direction is formed by the opening holes, as seen in Fig. 12(b1) viewed from the arrow x1 and Fig. 12(b2) viewed from the arrow x2. Therefore, the thickness 14a of the mixing structure s shown in Fig. 12(a) in this embodiment is the through-length of each of the curved opening holes formed therein, and it is desirable that the through-length be at least equivalent to the longer minor axis diameter (not shown) of the fan-shaped opening holes h5 and h7.

[0077] Therefore, as described above, in this embodiment, the opening area of ​​the communication port k can be made smaller or larger by adjusting the degree of shift so that the mixing structure portion s3 and the mixing structure portion s4 are effectively rotated relative to each other in the circumferential direction.When the device of the present invention is used for emulsions, making the opening area smaller will have the effect of further contributing to the finer refinement of the dispersed phase, or when the device of the present invention is used to mix different solutions of the same nature, such as hydrophilic or hydrophobic solutions, it will have the effect of promoting the degree of mixing, and in either case it can be expected that the pumping operation (number of pumps) will be shortened.

[0078] 3(a), (b), (c), and (d), and corresponds to the mixing structure s1 provided on connectors d1 and d2 shown in Fig. 3(a) or connectors d1' and d2' shown in Fig. 3(c) being faced to each other on the x-axis, rotated by a certain angle, and butted together with their respective opening hole positions offset. Alternatively, by molding one mixing structure shown in Fig. 2 with the opening holes provided on the left and right molding core pins offset from each other, it is also possible to form device d having a bending opening hole by integral molding without butting together the two left and right connectors.

[0079] Therefore, assuming that the mixed structure portion s1 of the connector d1 shown in Figure 3(a) corresponds to the mixed structure portion s3 of Figure 12(a), and the mixed structure portion s2 of the connector d2 shown in Figure 3(c) corresponds to the mixed structure portion s4 of Figure 12(a), when these are placed face to face on the x-axis and butted together, the device d of the present invention shown in Figure 3(b) can be formed, which, when viewed from the x1 arrow view of Figure 12(a), becomes an opening hole having a communication port k as shown in Figure 12(b1), and when viewed from the x2 arrow view, becomes an opening hole having a communication port k as shown in Figure 12(b2).

[0080] The opening holes shown in Figures 11 and 12 are partially bent when viewed on the x-axis and therefore have a communication port k, but in the example device d shown in Figure 3(b), by aligning the two connectors d1 and d2 facing each other on the x-axis and adjusting the degree of mutual rotation, it is also possible to form a device d according to the present invention in which the opening holes, which do not have a communication port k, are fully bent (not shown) as shown in Figures 13(b1) and (b2).

[0081] In other words, the opening holes h5 and h7 of the mixing structure s3 as viewed from the x1 arrow in Figure 13(a) and s4 as viewed from the x2 arrow are formed at the positions shown in Figure 13(a1) and Figure 13(a2), respectively, but the opening holes h5 and h7 of the mixing structure s4 are not visible as shown in Figure 13(b1) as viewed from the x1 arrow, and similarly the opening holes h5 and h7 of the mixing structure s3 are not visible as shown in Figure 13(b2) as viewed from the x2 arrow, and a device d according to the present invention shown in Figure 3(b) can be formed in which the liquid delivery path is fully curved.

[0082] <Device 1> The device of the present invention is for mixing two liquids by manual pumping using two injection syringes on the left and right. As shown in Figures 2 to 5, the device is of a straight type in which the left and right injection syringes are on the x-axis shown in Figure 1. In addition to this, as a way to reduce the effort required for pumping, it is also possible to make it a bent type in which the left and right connectors form an angle of, for example, 90 degrees as shown in Figure 14, or a balanced type in which the left and right connectors are made balanced as shown in Figure 15. Since the direction in which the plungers of these two injection syringes on the left and right are pressed is downward in this figure (not shown), it is also possible to make it easier to pump by placing the bottom 15 of the device on a surface such as a table.

[0083] Therefore, the device according to the present invention shown in Figure 14(a) is constructed such that the mixing structure s is integrally molded with the connector d1 body and the connector d2 body, with the molding resin connected to each other at an installation position q 7.5 to 12 mm away from the connector edge w, as described above, as shown in Figure 14(a). The two connectors are abutted and fixed together as shown in Figure 14(b) to prevent leakage at the butted portion c. The connectors d1 and d2 according to the present invention can be injection molded as a single component having the mixing structure s because there are no so-called forced-out molding areas that are impossible to achieve in injection molding. The device according to the present invention shown in Figure 14(b) can be constructed by butting two single molded products together, as described above. In this embodiment, a passing chamber 6 is formed.

[0084] <Device 2> The device according to the present invention shown in Fig. 15 next, similar to the device shown in Fig. 14, is constructed in such a way that the mixing structure s is integrally molded with the connector d1 body and the connector d2 body, with the molding resin connected to each other at an installation position q 7.5 to 12 mm away from the connector edge w, as shown in Fig. 15(a). The two connectors are butted together at the butted portion c, as shown in Fig. 15(b), to prevent leakage. The connectors d1 and d2 according to the present invention can be integrally injection molded as a single component having the mixing structure s because there are no so-called forced-cutting portions that are impossible to achieve in injection molding. The device according to the present invention shown in Fig. 15(b) can be constructed by butting two single molded components together, as described above. In this embodiment, a passage chamber 6 is formed.

[0085] (Experimental Example 1) 5 cc of a solution of saline dyed with red ink as red hydrophilic solution 1 and 5 cc of soybean oil as hydrophobic solution 2 were poured into a general-purpose three-way stopcock (B-BRAUN Discofix) without a mixing structure according to the present invention. TIFF0007762842000002.tif7170The degree of mixing was measured by observing the number of pumping strokes until no transparent areas remained in the entire mixed solution. The results are shown in Table 2.

[0086] [Table 2]

[0087] In this way, by using the device according to the present invention, two different liquids can be mixed efficiently with fewer pumping operations. Furthermore, as described above, when an S / O type slurry solution in which fine particles S are dispersed in oil O in one injection syringe and an aqueous solution W to which a water-soluble surfactant has been added in another injection syringe are pumped and emulsified using the device according to the present invention, the size of the openings provided in the mixing structure according to the present invention can be appropriately designed to be, for example, five times larger than the openings provided in the mixing structure so that the fine particles can easily pass through, thereby easily producing an S / O / W type emulsion in which the fine particles are encapsulated in oil droplets. [Industrial Applicability]

[0088] As a result of extensive research, we have developed a practical device for mixing two liquids by pumping both left and right injection syringes, which allows for low molding and product costs and can be introduced to the market at a low price. The market for the device of the present invention is considered to be a market for products with no expected added value, and product design is required to maximize effectiveness while keeping manufacturing costs as low as possible. The device of the present invention fully satisfies these marketability challenges, requiring fewer parts to assemble than prior art and eliminating the hassle of assembly, making it a realistic market for both product manufacturers and users. [Brief explanation of the drawings]

[0089] [Figure 1] 1 is an exploded perspective view of a heterogeneous solution mixing device according to the present invention. [Figure 2] (a) A side cross-sectional view of a device according to the present invention; (b) A side cross-sectional view of a mixing structure according to the present invention. [Figure 3] (a)(c) Side cross-sectional views of connectors with mixed structure sections on the left and right, and (b)(d) side cross-sectional views of a device formed by butting together left and right connectors. [Figure 4] 4 is a cross-sectional side view of a device having a different structure than the mixing structure of FIG. 3. [Figure 5] FIG. 5 is a side cross-sectional view of the device of FIG. 4 in which the left and right connectors are not butted together. [Figure 6] (a) An example of an opening hole with a small skeleton wire diameter, (b) an example of an opening hole with a large skeleton wire diameter, and (c) an example of an opening hole with a preferable skeleton wire diameter. [Figure 7] (a1) (b1) is a perspective view of an embodiment in which dispersed phase particles are released from an opening hole, and (a2) (b2) are views taken along the y arrow. [Figure 8] (a1), (b1), and (c1) are exploded perspective views of the opening holes of the mixing structure part according to the present invention, and (a2), (b2), and (c2) are side views thereof, respectively. [Figure 9]1A is a cross-sectional view showing an example of a mixing structure having a narrow skeleton line width, FIG. 1B is a cross-sectional view showing one of its opening holes, and FIG. 1C is a cross-sectional view showing the thickness of this mixing structure. [Figure 10] (a)(b) Example of opening holes in the mixing structure. [Figure 11] (a) An exploded perspective view of a partially curved opening hole, (b) a view seen from the z direction of (a), (c) a view seen from the x direction of (a), and (d) a view seen from the y direction of (a). [Figure 12] (a) A three-dimensional perspective view of one embodiment of a mixed structure part with an opening hole arrangement of a partially curved through-path (opening holes not shown), (a1) an opening hole arrangement diagram as viewed from the x1 arrow of (a), (a2) an opening hole arrangement diagram as viewed from the x2 arrow of (a), (b1) a communication hole formation diagram as viewed from the x1 arrow of (a), (b2) a communication hole formation diagram as viewed from the x2 arrow of (a). [Figure 13] (a) A three-dimensional oblique view of one embodiment of a mixed structure part with an opening hole arrangement of a completely curved through-path (opening holes not shown), (a1) an opening hole arrangement diagram as viewed from the x1 arrow of (a), (a2) an opening hole arrangement diagram as viewed from the x2 arrow of (a), (b1) a communication hole formation diagram as viewed from the x1 arrow of (a), (b2) a communication hole formation diagram as viewed from the x2 arrow of (a). [Figure 14] (a) A side cross-sectional view of a connector in which left and right connectors each have a mixed structure portion, and (b) a side cross-sectional view of a device in which the left and right connectors are butted together. [Figure 15] (a) A side cross-sectional view of a connector in which left and right connectors each have a mixed structure portion, and (b) a side cross-sectional view of a device in which the left and right connectors are butted together. [Explanation of symbols]

[0090] 1, 2 Injection syringe J1, J2 plungers N1, N2 solution d device g Device body x device axis direction s, s1, s2, s3, s4 mixed structure w Connector edge q Installation position 3, 4 Connection d1, d2, d3, d4 connectors h, h1, h2, h3 opening hole f skeleton c Match 5. Device lumen (mixing structure diameter) 6 Passage chamber Dr. Dispersed phase that makes up emulsion Dispersed phase droplets that make up Dp emulsion 7a, 7b, 7c, 7d Open hole cylindrical body 8a, 9a, 9b Wetted line 10 Major axis diameter of opening hole cross section 11 Minor axis diameter of opening hole cross section 12a, 12b, 12c Opening hole penetration length (thickness of mixing structure part) u Fluid flow direction 13a Minor axis diameter of opening hole cross section 13b Major axis diameter of opening hole cross section 13c Penetration length of opening hole (thickness of mixing structure part) h4, h5, h6, h7 opening hole k Communication port m interface 14a Thickness of mixing structure (penetration length of opening hole) 15 Bottom

Claims

[Claim 1] A cylindrical resin device for mixing two liquids in two injection syringes on the left and right sides by pumping, the device being constructed by butting together two cylindrical connectors a, one of which has a peripheral edge having a connection part connectable to an injection syringe, and a mixing structure part having an opening hole provided in the inner cavity of the connector a at a distance of 7.5 mm to 12 mm from the peripheral edge of the connector a on the side connecting to the injection syringe so as to divide the inner cavity of the connector a into two chambers, or provided so as to cover the peripheral edge of the connector a on the side opposite to the peripheral edge connectable to the injection syringe, and the mixing structure part being fitted or joined to the connector a as a separate part. a mixing device in which the connectors a are connected to the connector a with a series of resin without being joined and are formed by integral injection molding, and the two connectors a are butted together with the peripheral portion opposite the connecting portion facing each other to form a liquid-tight joint, and by butting the connectors a together coaxially, the opening holes formed in the mixing structure portions of the two connectors respectively become straight opening holes, or by butting the connectors a together while rotating them a certain angle on the axis and butting them together in a shifted state, the opening holes formed in the mixing structure portions of the two connectors respectively become curved opening holes, and as a result, the mixing device has two mixing structures in the inner cavity.

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