Organoruthenium Complexes as Catalysts (Precursors) for Olefin Metathesis with Long Shelf-Life Stability

Abstract

Embodiments according to the present invention include organoruthenium compounds of formula I: [Formula 1] TIFF2024510064000073.tif28167, where X, Y, L1, L2, L3, R1 and R2 are as defined herein. Also disclosed herein is the use of organoruthenium compounds of formula I as catalysts (precursors) for olefin metathesis reactions, as well as methods for carrying out olefin metathesis reactions.

Description

[Technical Field]

[0001] The present invention relates to a series of long shelf-life stable metal complexes, their use as catalysts (precursors) in metathesis reactions, and methods for conducting metathesis reactions. More particularly, the present invention relates to a series of organoruthenium compounds that exhibit long shelf-life stability and, when activated under suitable conditions, exhibit high catalytic activity for a wide range of metathesis reactions. The present invention also relates to methods for making these compounds. Accordingly, the compounds of the present invention are useful as catalysts (precursors) for conducting a wide variety of olefin metathesis reactions, including, in particular, ring-opening metathesis polymerization (ROMP). [Background technology]

[0002] Olefin metathesis is an important tool in organic synthesis (R.H. Grubbs (Ed.), A.G. Wenzel (Ed.), D.J. O'Leary (Ed.), E. Khosravi (Ed.), Handbook of Olefin Metathesis, Vol. 2, Vol. 3, 2015, John Wiley & Sons, Inc., p. 1608).

[0003] Many ruthenium complexes that actively catalyze olefin metathesis reactions are known in the art (see, for example, Vougioukalakis, GC; Grubbs, RH Chem. Rev. 2010, 110, 1746). Third-generation complexes (Gru-III, Ind-III, etc.) have been shown to be very useful catalysts (precursors) for ring-opening metathesis polymerization (ROMP) reactions.

[0004] [ka]

[0005] While third-generation catalysts initiate metathesis reactions very rapidly, in some metathesis applications, such as templated ROMP polymerization, it is advantageous to use catalysts (precursors) that do not initiate the reaction immediately after addition to the substrate, but only after appropriate initiation by chemicals, temperature, or light. Complexes characterized by delayed initiation are often referred to as "dormant catalysts" or "latent catalysts" (Monsaert, S.; Vila, A.L.; Drozdzak, R.; Van Der Voort, P.; Verpoort, F., Chem. Soc. Rev., 2009, 38, 3360; R. Drozdzak, N. Nishioka, G. Recher, F. Verpoort, Macromol. Symp. 2010, 293, 1-4). Exemplary "latent catalysts" are complexes A to F, as well as the recently obtained P-1 and P-2 (Pietraszuk, C.; Rogalski, S.; Powala, B.; Mitkiewski, M.; Mubicki, M.; Spolnik, G.; Danikiewicz, W.; Wozniak, K.; Pazio, A.; Szadkowska, A.; Kozlowska, A.; Grela, K., Chem. Eur. J, 2012, 18, 6465-6469).

[0006] Template ROMP polymerization allows the production of finished products. Dicyclopentadiene is one of the monomers commonly used in template polymerization. Polydicyclopentadiene, obtained by polymerization of dicyclopentadiene, is characterized by particularly low moisture absorption and resistance to stress and high temperatures. This is why parts for passenger cars and specialized containers for the chemical industry are more often produced by (template) ROMP polymerization of dicyclopentadiene. Summary of the Invention [Problem to be solved by the invention]

[0007] U.S. Patent No. 9,328,132 (B2), the relevant portions of which are incorporated herein by reference, addresses some of these deficiencies faced in the art in achieving more robust "latent catalysts" for olefin metathesis reactions. However, there remains a need for improved "latent catalysts" that can be activated under the desired ROMP polymerization conditions and based on the intended end use.

[0008] Moreover, there remains a need for latent catalysts that lie dormant and can be rapidly activated with high activity upon activation.

[0009] Accordingly, the object of the present invention is to provide a series of improved "latent catalysts" that are stable at ambient temperature for several months on a shell (as a solid) and in mixtures with highly reactive monomers (e.g., DCPD) and only show high activity upon activation.

[0010] It is also an object of the present invention to provide methods for preparing the organoruthenium latent catalysts disclosed herein.

[0011] Other objects and further scope of applicability of the present invention will become apparent from the detailed description below. [Means for solving the problem]

[0012] From the viewpoint of practical industrial applications, it is crucial that the catalyst (precursor) is stable in the presence of oxygen and moisture during its synthesis, purification, preparation of mixtures with monomers, handling, storage, transportation, and its use in metathesis reactions. The development of stable and active catalysts (precursors) for the metathesis of olefins reported in the literature significantly broadens the scope of possible uses for this transformation. Nevertheless, due to their limited stability to oxygen and moisture, these complexes are still prepared and used in metathesis reactions under an inert gas atmosphere and in dry solvents.

[0013] Surprisingly, it has now been discovered that ruthenium complexes represented by Formula I are stable in the presence of air and moisture and do not initiate ROMP of (unactivated) activated monomers for days to months. Additionally, complexes represented by Formula I exhibit improved activity once activated.

[0014] [ka]

[0015] (In the formula, X is ArO, and Ar is (C6-C 10 ) aryl, Y is an anionic ligand; L1 is (C6~C 10 ) an aryl-substituted imide group; L2 is SR 11 and R 11 is (C1~C 10 ) alkyl, (C1-C 16 ) Perhaloalkyl, (C3-C 16 ) cycloalkyl, (C2-C 16 ) alkenyl, (C6-C 14 ) Aryl, (C6-C 14 ) Perhaloaryl and (C3-C 12 )Heterocyclyl, (C4-C 20 ) alkylaryl; L3 is a neutral ligand, R1 is hydrogen and (C1 to C 20 ) alkyl; R2 is (C4~C 16 ) alkenyl, (C6-C 14 ) Aryl, (C6-C 14 ) Perhaloaryl and (C3-C 12 ) heterocyclyl; or R1 and R2, together with the carbon atom to which they are attached, are unsubstituted or (C1-C4) alkyl, (C1-C 16) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) fused monocyclic or bicyclic rings (C8-C 12 ) forming an aromatic ring, or R1 and R2, together with the carbon atom to which they are attached and including Y, are unsubstituted or (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) fused monocyclic or bicyclic rings (C8-C 12 ) forming an aromatic heterocycle).

[0016] Furthermore, it should be noted that all stereoisomers, including but not limited to enantiomeric and diastereomeric forms of the compounds of formula (I), are part of the present invention.

[0017] After suitable activation, the complexes of general formula (I) actively catalyze metathesis reactions carried out in the presence of air. Moreover, the complexes of general formula (I) actively catalyze metathesis reactions only after chemical activation, and are highly insensitive to thermal activation. These properties allow excellent control over the reaction initiation time, which is particularly useful for ROMP-type reactions. Surprisingly, it has been observed that the complexes of general formula (I) are highly stable at ambient conditions and can be stored by themselves or in combination with a wide variety of polymerizable olefin monomers for periods ranging from several days to several months, e.g., up to three months or longer.

[0018] Furthermore, it was surprisingly observed that compounds of general formula (I) enabled the preparation of polydicyclopentadiene (polyDCPD) by a ROMP-type reaction carried out in air, but with significantly less catalyst (precursor) than with classical complexes. Even 100 ppm (parts per million by weight) of a complex according to the present invention containing an NHC ligand (an N-heterocyclic carbene ligand, see below) effectively catalyzed the polymerization of dicyclopentadiene (DCPD). This amount corresponds to a molar ratio of monomer to catalyst (precursor) of 65,000:1. Therefore, this amount of catalyst (precursor) was less than half that required for catalyst G (M. Perring, NB Bowden Langmuir, 2008, 24, 12480-10487).

[0019] Surprisingly, it has now been discovered that the thio derivatives of general formula (I) described herein provide very high storage stability when compared to various similar compounds reported in the art. Despite their storage stability, the compounds of formula (I) exhibit very high catalytic activity, as evidenced by the examples set forth below.

[0020] Accordingly, the compounds of general formula (I) according to the present invention as described above are provided as catalysts (precursors) for olefin metathesis reactions.

[0021] In some embodiments, the compound of formula (I) is

[0022] [ka] It has.

[0023] In some other embodiments, the organoruthenium compound within the scope of formula (I) has formula (II):

[0024] [ka]

[0025] (In the formula, X is unsubstituted or (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) aryloxy substituted by alkylaryl; Z is oxygen or sulfur; L1 is unsubstituted or (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) a phenylimido group substituted with alkylaryl; L2 is SR 11 and R 11 is (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl and (C3-C7) cycloalkyl, (C4-C 20 ) alkylaryl; L3 is a neutral ligand, R3 is hydrogen, (C1 to C 20 ) Alkyl, (C2-C 20 ) alkenyl, (C2-C 20 ) alkynyl and (C6-C 10 ) aryl; R4, R5, R6 and R7 are the same or different and each independently represent hydrogen, halogen, (C1 to C 16 ) alkyl, (C1-C 16 ) alkoxy, (C1-C 16 ) perfluoroalkyl, (C3-C7) cycloalkyl, (C2-C 16 ) alkenyl, (C6-C 14 ) Aryl, (C6-C 14 ) Perfluoroaryl, (C3-C 12 ) heterocyclyl, -OR 18 , -NO2, -COOH, -COOR 18 , -CONR 18 R 19 , -SO2NR 18 R 19 , -SO2R 18, -CHO, -COR 18 and R 18 and R 19 are the same or different and each independently represent (C1-C6) alkyl, (C1-C6) perhaloalkyl, (C6-C 14 ) Aryl, (C6-C 14 ) perhaloaryl; or Two or more of R4, R5, R6 and R7, together with the carbon atoms to which they are attached, are unsubstituted or (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) fused (C4-C8) carbocyclic rings substituted by alkylaryl, or unsubstituted or (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) forming a fused aromatic ring substituted by alkylaryl).

[0026] In some embodiments, the compound of formula (II) has the following: Z is oxygen, R3 is hydrogen; R4, R5, R6, and R7 are the same or different and are each independently selected from the group consisting of hydrogen, methyl, ethyl, and —NO2;

[0027] [ka]

[0028] has the formula (III): [ka]

[0029] (In the formula, a and b are 0 to 4 is an integer, R8, R9 and R 10may be the same or different, and each independently represents hydrogen, halogen, (C1 to C 16 ) alkyl, (C1-C 16 ) alkoxy, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl, (C2-C 16 ) alkenyl, (C6-C 14 ) Aryl, (C6-C 14 ) Perhaloaryl, (C3-C 12 ) heterocyclyl, -OR 18 , -NO2, -COOH, -COOR 18 , -CONR 18 R 19 , -SO2NR 18 R 19 , -SO2R 18 , -CHO, -COR 18 and R 18 and R 19 are the same or different and each independently represent (C1-C6) alkyl, (C1-C6) perhaloalkyl, (C6-C 14 ) Aryl, (C6-C 14 ) perhaloaryl; R 11 is (C1~C 16 ) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl, (C6-C 14 ) Aryl, (C6-C 14 ) Perhaloaryl and (C3-C 12 )Heterocyclyl, (C4-C 20 ) alkylaryl) L3 is an N-heterocyclylcarbene ligand of formula (IVA) or (IVB):

[0030] [ka]

[0031] (In the formula, R 12 and R 17are the same or different, and each independently represents (C1 to C 12 ) Alkyl, (C3-C 12 ) cycloalkyl, (C2-C 12 ) alkenyl and (C6-C 14 )aryl, which is unsubstituted or selected from the group consisting of (C1-C4)alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) substituted by alkylaryl, R 13 , R 14 , R 15 and R 16 are the same or different and each independently represent hydrogen, (C1-C6) alkyl, (C1-C6) perhaloalkyl, (C1-C6) alkoxy, or halogen; 12 ) Alkyl, (C3-C 12 ) cycloalkyl, (C2-C 12 ) alkenyl, (C6-C 14 ) aryl; or R 13 , R 14 , R 15 , R 16 are optionally unsubstituted or, together with the carbon atoms to which they are attached, (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) fused (C4-C8) carbocyclic rings substituted by alkylaryl, or unsubstituted or (C1-C4) alkyl, (C1-C 16 ) perhaloalkyl, (C3-C7) cycloalkyl or (C4-C 20 ) can form fused aromatic rings substituted by alkylaryl).

[0032] In still other embodiments, the compound of formula (II) according to the present invention is

[0033] Groups of formula (IIIA): [ka]

[0034] Group of formula (IIIB): [ka]

[0035] A group of formula (IIIC): [ka]

[0036] Groups of formula (IIID): [ka]

[0037] Groups of formula (IIIE): [ka]

[0038] A group of formula (IIIF): [ka] and

[0039] A group of formula (IIIG): [ka]

[0040] selected from the group consisting of [ka] It has.

[0041] In some embodiments, any of the known N-heterocyclic carbene compounds can be used as the L3 ligand. Non-limiting examples of such N-heterocyclic compounds are selected from the group consisting of pyridine, 4-(N,N-dimethylamino)pyridine, 3-bromopyridine, piperidine, morpholine, pyridazine, pyrimidine, pyrazine, piperazine, 1,2,3-triazole, 1,3,4-triazole, 1,2,3-triazine, and 1,2,4-triazine. Accordingly, in some embodiments, the compound of formula (I) or (II) according to the present invention is

[0042] [ka] and L3 selected from the group consisting of:

[0043] Representative, non-limiting examples of compounds of formula (II) include:

[0044] [ka]

[0045] [1,3-bis(2,6-diisopropylphenyl)-2-imidazolidinylidene]{2-[(E)-({2-[methylthio-κS]phenyl}imino-κN)methyl]phenoxide-κO}[2-(oxide-κO)benzylidene-κC]ruthenium(II),

[0046] [ka]

[0047] [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]{2-[(E)-({2-[isopropylthio-κS]phenyl}imino-κN)methyl]phenoxide-κO}[2-(oxide-κO)benzylidene-κC]ruthenium(II),

[0048] [ka]

[0049] [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]{2-[(E)-({2-[cyclohexylthio-κS]phenyl}imino-κN)methyl]phenoxide-κO}[2-(oxide-κO)benzylidene-κC]ruthenium(II), and

[0050] [ka]

[0051] [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]{2-[(E)-({2-[methylthio-κS]phenyl}imino-κN)methyl]phenoxide-κO}[2-(oxide-κO)benzylidene-κC]ruthenium(II).

[0052] The compound of general formula (I) can be prepared by any method known in the art.For example, WO2005 / 082819 A2 discloses a method for preparing various organometallic compounds, which is similar to the method for preparing the compound of formula (I), but involves reacting a suitable precursor with the thallium salt of the desired bidentate ligand (i.e., Schiff base) to form the organometallic compound described in the document.WO2011 / 009721 A1 discloses a similar method for preparing Schiff base bidentate ligand-containing compounds using silver salt of Schiff base.However, both of these methods require the use of hazardous thallium salt or expensive silver salt, and therefore are not practical in industry.

[0053] Advantageously, it has now been found that the compounds of the present invention can be very easily prepared using a variety of readily available alkali metal salts, such as potassium or sodium salts, such as potassium tert-butoxide, potassium tert-pentoxide, sodium tert-butoxide, and sodium tert-pentoxide.

[0054] Scheme I illustrates a method according to the present invention for the preparation of compounds of formula (Ib) which are within the scope of formula (I).

[0055] As shown in Scheme I, a suitable organoruthenium precursor compound of formula (Ia) is reacted with a suitable Schiff base of formula (IIIa) and a suitable alkali metal alkoxide of formula ROAl. In formulas (Ia) and (IIIa), a, b, Y, Z, L3, R3, R4, R5, R6, R7, R8, R9, R 10 and R 11 is as above. X a is a halogen selected from chlorine, bromine and iodine, and L4 is selected from tri(C1-C6)alkylphosphines, tri(C3-C8)cycloalkylphosphines and tri(C6-C 14 R is any suitable neutral ligand, including (C1-C8) alkyl and (C6-C8) aryl phosphines. Representative ligands of this type include, but are not limited to, tricyclohexylphosphine and triphenylphosphine. R is a phenyl phosphine, and may be any suitable neutral ligand, including (C1-C8) alkyl and (C6-C8) aryl phosphines. 14 ) aryl, and specific examples include methoxide, ethoxide, n-propoxide, isopropoxide, tert-butoxide, tert-pentoxide, and the like. Al is a metal, including lithium, sodium, potassium, and cesium. A compound of Formula (Ia) can be reacted with a compound of Formula (IIIa) in the presence of ROAl under ambient or superambient conditions. Generally, such reactions are carried out in a suitable organic solvent at a temperature of about 20°C to about 100°C or higher. In some embodiments, such reactions are carried out at a temperature of about 30°C to about 50°C. Any solvent that will dissolve the compound of Formula (Ia), the compound of Formula (IIIa), and ROAl can be used in this reaction. Suitable solvents include toluene, tetrahydrofuran, 1,4-dioxane, dichloromethane, dichloroethane, and any combination thereof.

[0056] [ka]

[0057] The present invention also relates to the use of the compound of general formula (I) as a catalyst (precursor) in a metathesis reaction. In some embodiments, the compound of general formula (I) is used as a catalyst (precursor) in a ring-closing metathesis, cross metathesis, homometathesis, or alkene-alkyne metathesis reaction. In other embodiments, the compound of general formula (I) is used as a catalyst (precursor) in a ring-opening metathesis polymerization reaction.

[0058] The present invention also relates to a process for carrying out the metathesis reaction of olefins, in which at least one olefin is contacted with a compound of general formula (I) as catalyst (precursor).

[0059] Generally, the metathesis reaction is carried out in an organic solvent. Any organic solvent that is contemplated to carry out such a polymerization reaction can be used. Non-limiting examples of such organic solvents include dichloromethane, dichloroethane, toluene, ethyl acetate, and mixtures of any combination thereof.

[0060] In some embodiments, the metathesis reaction is carried out without any solvent. In other embodiments, the metathesis reaction is carried out in the presence of a chemical activator. Typically, the chemical activator is a Bronsted or Lewis acid or a halo derivative of an alkane or silane. Non-limiting examples of such activators include hydrogen chloride, chlorotrimethylsilane, or p-toluenesulfonic acid.

[0061] In some embodiments, the metathesis reaction is a ring-opening metathesis polymerization of dicyclopentadiene.

[0062] In still other embodiments, the catalyst (precursor) of general formula (I) is added to dicyclopentadiene in solid form.

[0063] In one embodiment, the polymerization reaction is initiated by heating a mixture of dicyclopentadiene and the catalyst (precursor) of general formula (I) to a temperature of 30° C. or higher.

[0064] In some embodiments, the starting material contains at least 94% by weight dicyclopentadiene.

[0065] In another embodiment, the metathesis reaction is carried out at a temperature of 20 to 120° C. In yet another embodiment, the metathesis reaction is carried out for a period of 1 minute to 24 hours.

[0066] In some embodiments, the metathesis reaction is carried out in the presence of an additive that promotes cross-linking.

[0067] In one embodiment, the metathesis reaction is carried out using an amount of catalyst (precursor) of 1000 ppm or less.

[0068] Throughout the present specification and claims, when ppm (parts per million) units are used in reference to amounts of substances, this is on a weight basis.

[0069] As the inventors do not wish to be bound by any particular mechanism of catalysis, the term "catalyst (precursor)" is used to indicate that the compounds according to the invention may be either catalysts themselves or precursors of the active species that become the actual catalysts.

[0070] Definitions of groups not defined below are intended to have the broadest meaning known in the art.

[0071] The term "optionally substituted" means that one or more hydrogen atoms of the group in question may be replaced with a specified group, provided that such replacement results in the formation of a stable compound.

[0072] The term "halo" or "halogen" refers to an element selected from F, Cl, Br, I.

[0073] The term "alkyl" refers to a saturated, straight or branched chain hydrocarbon substituent having the specified number of carbon atoms. Non-limiting examples of alkyl are methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, and pentyl.

[0074] The term "alkoxy" refers to an alkyl substituent as defined above attached through an oxygen atom.

[0075] The term "perhaloalkyl" refers to an alkyl as defined above in which all hydrogens have been replaced with halogen atoms, which may be the same or different.

[0076] The term "cycloalkyl" refers to a saturated monocyclic or polycyclic hydrocarbon substituent having the specified number of carbon atoms. Non-limiting examples of cycloalkyl substituents are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl.

[0077] The term "alkenyl" refers to an acyclic straight or branched hydrocarbon chain having the specified number of carbon atoms and containing at least one carbon-carbon double bond. Non-limiting examples of alkenyl are vinyl, allyl, 1-butenyl, and 2-butenyl.

[0078] The term "aryl" refers to an aromatic monocyclic or polycyclic hydrocarbon substituent having the specified number of carbon atoms. Non-limiting examples of aryl are phenyl, mesityl, anthracenyl.

[0079] The term "heterocyclic" refers to aromatic and non-aromatic cyclic substituents having a specified number of carbon atoms, where one or more carbon atoms are replaced by a heteroatom such as nitrogen, phosphorus, sulfur, or oxygen, provided that there are no two directly connected oxygen or sulfur atoms in the ring. Non-aromatic heterocyclic groups can contain 4 to 10 atoms in the ring, while aromatic heterocyclic groups necessarily contain at least 5 atoms in the ring. Benzofused systems also belong to the heterocyclic group. Non-limiting examples of non-aromatic heterocyclic groups are pyrrolidinyl, tetrahydrofuranyl, dihydrofuranyl, tetrahydrothienyl, tetrahydropyranyl, dihydropyranyl, tetrahydrothiopyranyl, piperidinyl, morpholinyl, thiomorpholinyl, 2-pyrrolinyl, and indolinyl. Non-limiting examples of aromatic heterocyclic groups include pyridinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, furyl, and thienyl. The above groups may be bonded via a carbon atom or a nitrogen atom. For example, the substituent resulting from the bonded pyrrole may be either pyrrol-1-yl (N-bonded) or pyrrol-3-yl (C-bonded).

[0080] The term "neutral ligand" refers to an uncharged substituent capable of coordinating to a ruthenium atom. Non-limiting examples of such ligands include N-heterocyclic carbene ligands, amines, imines, phosphines and their oxides, alkyl and aryl phosphites and phosphates, ethers, alkyl and aryl sulfides, coordinated hydrocarbons, haloalkanes, and haloarenes. The term "neutral ligand" also encompasses N-heterocyclic compounds, non-limiting examples of which are pyridine, 4-(N,N-dimethylamino)pyridine (DMAP), 3-bromopyridine, piperidine, morpholine, pyridazine, pyrimidine, pyrazine, piperazine, 1,2,3-triazole, 1,3,4-triazole, 1,2,3-triazine, and 1,2,4-triazine.

[0081] The term "anionic ligand" refers to a substituent capable of coordinating to a metal center and having a charge capable of complementing the charge of the metal center, said complementation being either complete or partial. Non-limiting examples of anionic ligands are fluoride, chloride, bromide or iodide anions, carboxylate anions, alcohol and phenol anions, thiol and thiophenol anions, (organo)sulfate and (organo)phosphate anions, and anions of esters thereof.

[0082] The term "carbene" refers to a molecule containing a neutral carbon atom with a valence of two and two unpaired valence electrons. The term "carbene" also encompasses carbene analogs in which the carbon atom is replaced with another chemical element, such as boron, silicon, nitrogen, phosphorus, sulfur, etc. The term "carbene" is particularly relevant to N-heterocyclic carbene (NHC) ligands. Non-limiting examples of NHC ligands are:

[0083] [ka] is.

[0084] The term "stereoisomers," as used herein, refers to all isomers of individual molecules that differ only in the orientation of their atoms in space. Typically, this term includes mirror image isomers, usually formed by at least one chiral center (enantiomer). When compounds according to the present invention have two or more chiral centers, stereoisomers may additionally exist as diastereomers, and particular individual molecules may also exist as geometric isomers (cis / trans). Similarly, certain compounds of the present invention may exist in a mixture of two or more structurally distinct forms that undergo rapid equilibration, commonly known as tautomers. Representative examples of tautomers include keto-enol tautomers, phenol-keto tautomers, nitroso-oxime tautomers, imine-enamine tautomers, and the like. It is understood that all such isomers and mixtures thereof, in any ratio, are encompassed within the scope of the present invention.

[0085] Non-limiting examples of preferred agents that promote the formation of cross-linking bonds are tert-butyl peroxide, di-tert-butyl peroxide, and mixtures thereof. [Example]

[0086] The following examples illustrate the procedures used to prepare compounds of the present invention and their use in olefin metathesis. The following examples are intended solely to illustrate the present invention and to describe certain embodiments thereof. The performance of catalyst (1B) according to the present invention was compared with LatMetSIMes3D3, the structure of which is presented below:

[0087] [ka]

[0088] The DCPD used in the following examples was purchased from a commercial source (Ultrene 99-6 from Cymetech) and contained 6 weight percent tricyclopentadiene (TCPD), triphenylphosphine, a solution of lithium bis(trimethylsilyl)amide, a solution of tert-potassium pentoxide, and a hydrogen chloride solution (commercially available) in 1,4-dioxane. All reactions were carried out under argon. Toluene was washed with citric acid, water, dried over 4 Å molecular sieves, and deoxygenated with argon. THF was dried over 4 Å molecular sieves and deoxygenated with argon. Example 1

[0089] Step 1: [ka]

[0090] A toluene solution of lithium bis(trimethylsilyl)amide (1 M, 12 mL, 1.1 equiv.) was added to a suspension of SIMesHBF (5.1 g, 1.15 equiv.) in toluene (82 mL). The resulting mixture was stirred at room temperature for 30 min and then placed in an oil bath heated to 80 °C. After 10 min, the compound of formula M10 (10 g, 11.3 mmol, 1 equiv.) was added, and the mixture was stirred for 10 min. Next, (E / Z)-2-(prop-1-en-1-yl)phenol (2.27 g, 1.5 equiv.) was added, and after another 30 min, triphenylphosphine (1.48 g, 0.5 equiv.) was added. The reaction mixture was stirred at 80 °C for 90 min, then cooled to room temperature and filtered through a short pad of silica gel. The silica gel pad was washed with toluene. The crude product was purified by crystallization and recrystallization from a dichloromethane / n-heptane mixture to give 4.2 g of a green solid in 46% yield.

[0091] Step 2: [ka]

[0092] A solution of tert-potassium pentoxide in toluene (1.7 M, 1.74 mL, 1.2 equiv.) was added to a solution of imine 1 (0.72 g, 1.2 equiv.) in tetrahydrofuran (23 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMetSIMesPPh3 (2 g, 2.47 mmol, 1 equiv.) was added, and the reaction was stirred at 41 °C for 45 min. The reaction mixture was filtered through a short pad of Celite. The Celite pad was washed with THF. The solvent was evaporated to dryness, and the crude product was crystallized from a dichloromethane / methanol mixture to give 0.95 g (51% yield) of black crystals. The compound was 1 H and 13 It was characterized by C NMR.

[0093]

number

[0094] [ka]

[0095] A solution of tert-potassium pentoxide in toluene (1.7 M, 5.23 mL, 1.2 equiv.) was added to a solution of imine 2 (2.41 g, 1.2 equiv.) in tetrahydrofuran (68.8 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMetSIMesPPh3 (6 g, 7.4 mmol, 1 equiv.) was added, and the reaction was stirred at 41 °C for 1 h. The reaction mixture was filtered through a short pad of Celite. The Celite pad was washed with THF. The solvent was evaporated to dryness, and the crude product was crystallized from a dichloromethane / methanol mixture to give 4.76 g (82% yield) of black crystals. 1 H and 13 It was characterized by C NMR.

[0096]

number

[0097] [ka]

[0098] A solution of tert-potassium pentoxide in toluene (1.7 M, 0.44 mL, 1.2 equiv.) was added to a solution of imine 3 (0.23 g, 1.2 equiv.) in tetrahydrofuran (11.9 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMetSIMesPPh3 (0.5 g, 0.62 mmol, 1 equiv.) was added, and the reaction was stirred at 41 °C for 1 h. The reaction mixture was filtered through a short pad of Celite. The Celite pad was washed with THF. The solvent was evaporated to dryness, and the crude product was crystallized from a dichloromethane / methanol mixture to give 0.23 g (45% yield) of black crystals. The compound was 1 H and13 It was characterized by C NMR.

[0099]

number

[0100] [ka]

[0101] A solution of tert-potassium pentoxide in toluene (1.7 M, 0.44 mL, 1.2 equiv.) was added to a solution of imine 4 (0.22 g, 1.2 equiv.) in tetrahydrofuran (13.9 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMetSIMesPPh3 (0.5 g, 0.62 mmol, 1 equiv.) was added, and the reaction was stirred at 41 °C for 1 h. The reaction mixture was filtered through a short pad of Celite. The Celite pad was washed with THF. The solvent was evaporated to dryness, and the crude product was crystallized from a dichloromethane / methanol mixture to give 0.20 g (40% yield) of a brown powder. Compound 4 was obtained. 1 H and 13 It was characterized by C NMR.

[0102]

number

[0103] Step 1: [ka]

[0104] A toluene solution of tert-potassium pentoxide (1.7 M, 139 mL, 1.05 equiv.) was added to a suspension of SIPrHBF (113 g, 1.05 equiv.) in toluene (2050 mL). The resulting mixture was stirred at room temperature for 30 min and then placed in an oil bath heated to 85 °C. After 20 min, M10 (200 g, 226 mmol, 1 equiv.) was added, followed by toluene (50 mL). The mixture was stirred for 30 min. Then, (E / Z)-2-(prop-1-en-1-yl)phenol (45.4 g, 1.5 equiv.) in toluene (50 mL) was added, followed by triphenylphosphine (59.2 g, 1 equiv.). The reaction mixture was stirred at 85 °C for 90 min, then cooled to room temperature and filtered through a short pad of silica. The silica gel pad was washed with toluene. The solvent was evaporated to dryness and the crude product was crystallized from a dichloromethane / methanol mixture to give 38.6 g of crystals, a yield of 19%.

[0105] Step 2: [ka]

[0106] A solution of tert-potassium pentoxide in toluene (1.7 M, 22 mL, 1.21 equiv.) was added to a solution of imine 1 (9.18 g, 1.22 equiv.) in tetrahydrofuran (288 mL), and the resulting mixture was stirred at room temperature for 30 min. Subsequently, LatMetSIPrPPh3 (27.73 g, 31 mmol, 1 equiv.) was added, and the reaction was stirred at 61 °C for 1 h, then cooled to room temperature and filtered through a short pad of Celite. The Celite pad was washed with tetrahydrofuran and dichloromethane. The solvent was evaporated to dryness, and the crude product was crystallized from a dichloromethane / n-heptane mixture to give 27.05 g of a brown powder (1B) as a mixture of diastereomers in 104% yield. The brown powder was dissolved in dichloromethane (500 mL). Methanol (150 mL) was then added portionwise to the stirring brown solution over a period of 5 h. The resulting solution was stirred at room temperature for 1 hour and filtered through filter paper. Slow evaporation of dichloromethane gave the single diastereomer 1B as black crystals. The product was recrystallized from a dichloromethane / methanol mixture to give 20.82 g of black crystals in 80% yield. 1 H and 13 It was characterized by C NMR.

[0107]

number

[0108] The compounds of the present invention were used to demonstrate the shelf life stability of the compounds of the present invention when compared to organoruthenium compounds disclosed in the art, as shown in Comparative Example 1 below.

[0109] The compound of Example 5, Compound 1B, was used in this study: 1B (14.93 mg, 40 mol ppm) was dissolved in 60 mL of Ultrene 99-6, designated Formulation A. The resulting solution was stored at room temperature under argon. The shelf life of Formulation A was monitored every two weeks in reaction with freshly prepared HCl-containing Formulation B (200 mol ppm).

[0110] Test procedure: A solution of hydrogen chloride in 5 mL of Ultrene 99-6 (1.85 μL of a 4 M solution in 1,4-dioxane, 200 molar ppm) was prepared and designated Formulation B. The resulting Formulation B was added to 5 mL of freshly prepared Formulation A (1.244 mg, 40 molar ppm of 1B). The final reactive formulation contained 20 molar ppm of 1B and 100 molar ppm of HCl. The results are summarized in Table 1.

[0111] [Table 1]

[0112] Formulation A was then stored at room temperature for 30 weeks. Freshly prepared Formulation B (5 mL of Ultrene 99-6 and hydrogen chloride, 1.85 μL of a 4 M solution in 1,4-dioxane, 200 molar ppm) was then added to 5 mL of Formulation A (1.244 mg, 40 molar ppm of 1B). The final reactive formulation contained 20 molar ppm of 1B and 100 molar ppm of HCl. The results are summarized in Table 2.

[0113] [Table 2]

[0114] From the data presented in Tables 1 and 2, it is clear that the catalytic activity of the compound of the present invention, i.e., 1B, is not adversely affected even after 30 weeks of storage at room temperature. In fact, the solution of Formulation A is more active after 30 weeks than it was immediately after preparation.

[0115] Comparative Example 1 LatMetSIMes3D3 (14.11 mg, 40 mol ppm) was dissolved in 60 mL of Ultrene 99-6 to give Formulation A. The resulting solution was stored at room temperature under argon. The shelf life of Formulation A was monitored every two weeks in reaction with freshly prepared HCl-containing Formulation B (200 mol ppm).

[0116] Test procedure: A mixture of 5 mL of Ultrene 99-6 and hydrogen chloride (1.85 μL of a 4 M solution in 1,4-dioxane, 200 molar ppm) was prepared and designated Formulation B. Formulation B was added to 5 mL of Formulation A (1.176 mg, 40 molar ppm of 1B). The final reactive formulation contained 20 molar ppm LatMetSIMes3D3 and 100 molar ppm HCl. The results are summarized in Table 3.

[0117] [Table 3]

[0118] [ka]

[0119] Five mL of fresh formulation B was prepared as described above. Formulation B was added to formulation A (5 mL, 40 molar ppm LatMetSIMes3D3) that had been stored for two weeks. The final reactive concentrate contained 20 molar ppm LatMetSIMes3D3 and 100 molar ppm HCl. The reactive formulation gelled and no exothermic peak was observed, which was the result of partial catalyst decomposition. Example 7

[0120] [ka]

[0121] A solution of tert-potassium pentoxide in toluene (1.7 M, 4.26 mL, 1.2 equiv.) was added to a solution of imine 5 (2.27 g, 1.2 equiv.) in 1,4-dioxane (56.0 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMetSIMesPCy3 (5 g, 6.0 mmol, 1 equiv.) was added, and the reaction was stirred at 95 °C for 2 h. The reaction mixture was cooled to room temperature and filtered through a short pad of Celite. The Celite pad was washed with 1,4-dioxane and dichloromethane. The solvent was evaporated to dryness, and the crude product was crystallized from a dichloromethane / n-heptane mixture to give 4.16 g of a brown powder (84% yield of crude product) of 5A as a mixture of diastereomers. The product was recrystallized from a dichloromethane / methanol mixture to give 3.05 g of dark brown or black crystals of pure 5A as a mixture of diastereomers in 61% yield. The pure diastereomer mixture was dissolved in dichloromethane (30 mL). Methanol (45 mL) was then slowly added. The resulting solution was stirred overnight at room temperature. The solvent was slowly evaporated to dryness to give 3.01 g of dark brown or black crystals of 5A as a single diastereomer in 61% yield. 1 H and 13 It was characterized by C NMR.

[0122]

number

[0123] [ka]

[0124] A solution of tert-potassium pentoxide in toluene (1.7 M, 4.26 mL, 1.2 equiv.) was added to a solution of imine 6 (2.36 g, 1.2 equiv.) in 1,4-dioxane (56.0 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMetSIMesPCy3 (5 g, 6.0 mmol, 1 equiv.) was added, and the reaction was stirred at 95 °C for 2 h. The reaction mixture was cooled to room temperature and filtered through a short pad of Celite. The Celite pad was washed with 1,4-dioxane and dichloromethane. The solvent was evaporated to dryness, and the crude product was crystallized from a dichloromethane / n-heptane mixture to give 4.74 g of a brown powder (94% yield of crude product) of 6A as a mixture of diastereomers. The brown powder was dissolved in a mixture of dichloromethane (30 mL) and methanol (150 mL). The resulting solution was stirred at room temperature overnight. Slow evaporation of dichloromethane gave 3.18 g of black crystals of 6A as a single diastereomer in 63% yield. 1 H and 13 It was characterized by C NMR.

[0125]

number

[0126] The structure of complex 1B, shown below, was determined by X-ray crystallography. Crystals of 1B for this analysis were grown from a dichloromethane / n-heptane solution.

[0127] [ka] Example 10

[0128] Step 1: [ka]

[0129] SIMesHBF4 (7.81 g, 19.8 mmol, 1.1 equiv.) was placed in a round-bottom flask under argon. Toluene (160 mL) was added, and the resulting suspension was heated up to 80 °C. LiHMDS (1 M in toluene, 19.8 mL, 1.1 equiv.) was then added, and the mixture was stirred for 3 min, followed by the addition of M10 (15.96 g, 18.0 mmol, 1 equiv.). After 15 min, complete conversion of M10 was confirmed by TLC plates (AcOEt / c-C6H 12 , 1:9, v / v). The temperature was raised to 110 °C, and (E / Z)-2-(prop-1-en-1-yl)-6-isopropylphenol (7.29 g, 36.0 mmol, 2 equiv.) was added. The resulting mixture was stirred for 20 min, after which tricyclohexylphosphine (5.55 g, 19.8 mmol, 1.1 equiv.) was added. Stirring was continued for an additional 2.5 h. The reaction mixture was then cooled to room temperature and filtered through a short pad of Celite. The filtrate was concentrated, and the crude product was purified by column chromatography (c-C6H 12 ~c-C6H 12 The solvent was removed and the crude product was crystallized twice from a dichloromethane / methanol mixture to give 5.26 g of a green solid in 33% yield. 1 H, 31 P and 13 It was characterized by C NMR.

[0130]

number

[0131] Step 2: [ka]

[0132] A solution of tert-potassium pentoxide in toluene (1.7 M, 0.34 mL, 1.2 equiv.) was added to a solution of imine 2 (0.157 g, 1.2 equiv.) in 1,4-dioxane (5 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMet(6-iPr)SIMesPCy3 (0.42 g, 0.48 mmol, 1 equiv.) was added, and the reaction was stirred at 95 °C for 3 h. The reaction mixture was filtered through a short pad of Celite. The Celite pad was washed with 1,4-dioxane. The solvent was evaporated to dryness. The crude product was dissolved in dichloromethane (3 mL) and heptane (15 mL). A brownish solid was filtered off and removed. The filtrate was concentrated to dryness, and the crude product was crystallized from a dichloromethane / methanol mixture. The dark brown crystals were filtered off, washed with methanol, and dried to give 0.19 g (40% yield). Compound 1 H and 13 It was characterized by C NMR.

[0133]

number

[0134] [ka]

[0135] A solution of tert-potassium pentoxide in toluene (1.7 M, 0.81 mL, 1.2 equiv.) was added to a solution of imine 1 (0.33 g, 1.2 equiv.) in 1,4-dioxane (11 mL), and the resulting mixture was stirred at room temperature for 30 min. LatMet(4-NO2)SIMesPCy3 (1.0 g, 1.14 mmol, 1 equiv.) was then added, and the reaction was stirred at 95 °C for 1.5 h. The reaction mixture was cooled to room temperature and concentrated to 40% of its original volume. The crude product was filtered off, washed with toluene and methanol, and recrystallized from a dichloromethane / methanol mixture to give 0.72 g of dark green crystals in 79% yield. The product was 1 H and13 It was characterized by C NMR.

[0136] Two diastereomers were observed: the minor diastereomer exhibited the characteristic benzylidene proton signal at 14.57 ppm, and the major diastereomer (95%) exhibited the characteristic benzylidene proton signal at 14.02 ppm.

[0137] 1 H and 13 C NMR peaks of the major diastereomer:

[0138]

number

[0139] Step 1: [ka]

[0140] Toluene (30 mL) was added to G2 (3 g, 3.53 mmol, 1 equiv.) in a round-bottom flask. Next, (E / Z)-2-(prop-1-en-1-yl)-4-methoxyphenol (0.75 g, 4.59 mmol, 1.3 equiv.) and tricyclohexylphosphine (1.29 g, 4.59 mmol, 1.3 equiv.) were added. The reaction mixture was stirred at 80 °C for 6 h and then cooled to room temperature. Half of the toluene was removed on a rotary evaporator, and heptane (15 mL) was added. The sticky solid was filtered off over Celite and removed. The filtrate was evaporated to dryness, and the solid residue was further dried under high vacuum. The crude product was crystallized from a dichloromethane / methanol mixture to give 2.6 g (86% yield) of an olive-green solid. 1 H and 31 It was characterized by P NMR.

[0141]

number

[0142] Step 2: [ka]

[0143] A solution of tert-potassium pentoxide in toluene (1.7 M, 0.49 mL, 1.2 equiv.) was added to a solution of imine 2 (0.23 g, 1.2 equiv.) in 1,4-dioxane (7 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMet(4-OMe)SIMesPCy3 (0.6 g, 0.7 mmol, 1 equiv.) was added, and the reaction was stirred at 95 °C for 5 h. The reaction mixture was filtered through a short pad of Celite. The Celite pad was washed with 1,4-dioxane. The solvent was evaporated to dryness. The crude product was dissolved in dichloromethane (3 mL), and heptane (15 mL) was added. A brownish solid was filtered off and discarded. The filtrate was concentrated to approximately 10 mL and stored in the refrigerator overnight. The dark brown crystals were filtered off and dried to give 0.53 g of crystals in 93% yield. Compound 1 was obtained. 1 H and 13 Characterization was performed by C NMR. Two diastereomers of the product were observed. Only the characteristic benzylidene proton and carbene carbon signals were obtained.

[0144]

number

[0145] [ka]

[0146] A solution of tert-potassium pentoxide in toluene (1.7 M, 0.49 mL, 1.2 equiv.) was added to a solution of imine 1 (0.20 g, 1.2 equiv.) in 1,4-dioxane (7 mL), and the resulting mixture was stirred at room temperature for 30 min. Then, LatMet(4-OMe)SIMesPCy3 (0.6 g, 0.7 mmol, 1 equiv.) was added, and the reaction was stirred at 95 °C for 3.5 h. The reaction mixture was filtered through a short pad of Celite. The Celite pad was washed with 1,4-dioxane. The solvent was evaporated to dryness. The crude product was dissolved in dichloromethane (3 mL) and filtered again through Celite. Heptane (15 mL) was added, and the dichloromethane was removed on a rotary evaporator. The crude product was filtered off, washed with heptane, and recrystallized from a dichloromethane / methanol mixture to give 0.44 g (80% yield) of dark brown crystals. Compound 1 H and 13 It was characterized by C NMR.

[0147]

number

[0148] While the present invention has been illustrated by the foregoing examples, it should not be construed as being limited thereby, and the present invention is intended to encompass the general scope disclosed above. Various modifications and embodiments can be made without departing from the spirit and scope thereof.

Claims

1. A compound of formula II, its enantiomers, diastereomers, geometric or other stereoisomers: 【Chemistry 1】 (In the formula: Z is oxygen; R ３ is hydrogen, R ４ , R ５ , R ６ and R ７ are the same or different and each independently represent hydrogen, methyl, ethyl, and —NO ２ is selected from the group consisting of 【Chemistry 2】 has formula (III) or formula (III-1): 【Transformation 3】 (In the formula, a and b are integers from 0 to 4, R ８ is hydrogen or (C 1 -C 16 ) alkyl, R 9 and R 10 are hydrogen, and R 11 is (C 1-16 ) alkyl or C 6 cycloalkylmethyl. The ruthenium atom is bonded to an oxygen anion, a nitrogen atom, and a sulfur atom of formula (III) or formula (III-1), L ３ is an N-heterocyclic carbene ligand of formula (IVA) or (IVB): 【Chemistry 4】 (In the formula, R １２ and R １７ are the same or different, and each independently represents (C １ -C3) alkyl substituted (C ６ ~C １４ ) aryl, R １３ , R １４ , R １５ and R １６ is hydrogen). 【Request Item 2】 【Chemistry 5】 but, A group of formula (IIIA): 【Transformation 6】 A group of formula (IIIB): 【Transformation 7】 and A group of formula (IIIC): 【Transformation 8】 2. The compound of claim 1 selected from the group consisting of:

3. L3 is, 【Chemistry 9】 2. The compound of claim 1 selected from the group consisting of: 【Request Item 4】 【Chemistry 10】 2. The compound of claim 1 selected from the group consisting of:

5. 10. A method for carrying out a metathesis reaction of olefins, comprising contacting at least one olefin with a compound of claim 1 as a catalyst (precursor).

6. The method of claim 5 , wherein the metathesis reaction is carried out in an organic solvent.

7. 6. The method of claim 5, wherein the metathesis reaction is carried out without any solvent.

8. 8. The method of claim 5, wherein the metathesis reaction is carried out in the presence of a chemical activator.

9. The method of claim 8, wherein the chemical activator is hydrogen chloride, chlorotrimethylsilane, or p-toluenesulfonic acid.

10. 10. The method of claim 5, wherein the metathesis reaction is a ring-opening metathesis polymerization of dicyclopentadiene.

11. 11. The process according to claim 10, wherein the catalyst (precursor) of general formula II is added to the dicyclopentadiene in solid form.

12. 12. The method according to claim 10 or 11, wherein the polymerization reaction is initiated by heating a mixture of dicyclopentadiene and the catalyst (precursor) of general formula II to a temperature of 30° C. or higher.

13. 13. The method of any one of claims 5 to 12, wherein the metathesis reaction is carried out in the presence of an additive that promotes the formation of crosslinks.

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