Immunoassay method with improved cross-reactivity

The immunoassay method improves specificity and reduces cross-reactivity by indirectly immobilizing anti-hapten antibodies on a carrier with fluorescein-modified antibodies and using anti-immunocomplex antibodies, allowing for precise hapten detection.

JP7803086B2Active Publication Date: 2026-01-21TOSOH CORP
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Patent Information

Application Number
JP2021182222
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2021-11-09
Publication Date
2026-01-21
Estimated Expiration
2041-11-09

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Patent Text Reader

Abstract

To provide a method for improving cross-reactivity, that is, improving specificity in an immunoassay method using anti-immunocomplex antibody.SOLUTION: A method of immunoassay includes the following steps (i) to (iii): (i) reacting an anti-hapten rabbit monoclonal antibody indirectly immobilized on a water-insoluble carrier with a hapten (for example, digoxin) in a solution to be measured; (ii) reacting a labeled anti-immunocomplex mouse monoclonal antibody with a hapten-anti-hapten antibody immune complex; and (iii) detecting a signal derived from the label.SELECTED DRAWING: Figure 2
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Citation Information

Patent Citations

  • Immunity measurement method and reagent therefor

    JP2001174460A

  • Improved binding assay

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  • Measuring method using Anti-immunocomplex antibody

    JP2021081317A

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    US20130231462A1

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    WO2021100459A1