Reaction analysis system, reaction analysis device, and reaction analysis method

Abstract

To make it possible to acquire a substance created by desired chemical reaction at higher purity while specifying a reaction state of the chemical reaction.SOLUTION: A reaction analysis system 1 comprises: a first flow channel through which reaction fluid obtained by mixing a plurality of reaction products in a mixer 13 flows; a second flow channel through which the reaction fluid obtained in the mixer 13 flows, and which has higher heat exchange efficiency than the first flow channel; a temperature measurement part 16 which measures the temperature distribution of the reaction fluid along the first flow channel; and a reaction analyzer 20 which specifies a reaction state of the reaction fluid on the basis of a reaction parameter showing a reaction state of reaction fluid obtained from the temperature distribution measured by the temperature measurement part 16.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present disclosure relates to a reaction analysis system, a reaction analysis device, and a reaction analysis method. [Background technology]

[0002] As a configuration for analyzing the state of a chemical reaction, Patent Document 1 describes a configuration for identifying the reaction state of a reaction fluid flowing through a flow reactor. The configuration in the patent document identifies the reaction state of the reaction fluid based on a reaction parameter that indicates the reaction state of the reaction fluid, which is obtained from the temperature distribution of the reaction fluid along the flow direction of the reaction fluid immediately after the start of the reaction. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent Publication No. 2021-159910 Summary of the Invention [Problem to be solved by the invention]

[0004] However, as the temperature of the reaction fluid in the flow reactor rises as the chemical reaction progresses, side reactions are more likely to occur. As a result, in conventional configurations, not only the reaction fluid in the specified reaction state but also substances produced by side reactions may be mixed into the reaction fluid, making it difficult to obtain only the substance produced by the desired chemical reaction with high purity.

[0005] An object of the present disclosure is to provide a reaction analysis system, a reaction analysis device, and a reaction analysis method that are capable of identifying the reaction state of a desired chemical reaction while obtaining a substance produced by the chemical reaction with higher purity. [Means for solving the problem]

[0006] According to some embodiments, the reaction analysis system includes a first flow path through which a reaction fluid obtained by mixing a plurality of reactants in a mixer flows, a second flow path through which the reaction fluid obtained in the mixer flows and which has a higher heat exchange efficiency than the first flow path, a temperature measurement unit that measures a temperature distribution of the reaction fluid along the first flow path, and a reaction analysis device that identifies a reaction state of the reaction fluid based on a reaction parameter that indicates a reaction state of the reaction fluid obtained from the temperature distribution measured by the temperature measurement unit.

[0007] In this way, the reaction analysis system identifies the reaction state based on reaction parameters obtained from the temperature distribution measured in the first flow path, which has a lower heat exchange efficiency than the second flow path. Therefore, the reaction analysis system can obtain useful reaction parameters from the temperature distribution of the reaction fluid and identify the reaction state of the reaction fluid with high accuracy based on the reaction parameters. Furthermore, because the reaction analysis system includes a second flow path, which has a higher heat exchange efficiency than the first flow path, it can prevent temperature increases and suppress side reactions. Therefore, the reaction analysis system can identify the reaction state of a desired chemical reaction while obtaining a substance produced by that chemical reaction with a higher purity.

[0008] The reaction analysis system according to one embodiment further includes a temperature regulator that adjusts the temperatures of the first flow path and the second flow path, thereby enabling the reaction analysis system to optimize the temperatures as reaction conditions that enable a desired chemical reaction to occur.

[0009] In one embodiment, the reaction analysis system further includes a fluid bath for immersing at least one of the first flow path and the second flow path in a temperature control fluid, and a pump for pumping the temperature control fluid from the outside to the inside of the fluid bath. Therefore, the reaction analysis system can adjust the heat exchange efficiency of at least one of the first flow path and the second flow path by adjusting the amount of temperature control fluid flowing in and out of the fluid bath.

[0010] In one embodiment of the reaction analysis system, the temperature measurement unit further measures the temperature distribution of the reaction fluid along the second flow path, so that the reaction analysis system can identify not only the reaction state of the reaction fluid along the first flow path but also the reaction state of the reaction fluid along the second flow path.

[0011] In one embodiment, the reaction analysis system further includes a valve that switches the connection of the mixer outlet between the first flow path and the second flow path. Therefore, the reaction analysis system can identify reaction conditions under which a desired chemical reaction can be carried out based on a reaction state corresponding to a temperature distribution of the reaction fluid along the first flow path, and by carrying out the chemical reaction under those conditions, it is possible to obtain a desired substance with high purity from the second flow path.

[0012] In one embodiment, the reaction analysis system further includes a valve for switching the connection between the outlet of the mixer and a third flow path through which the reaction fluid obtained in the mixer flows, the third flow path having a higher heat exchange efficiency than the second flow path, and the third flow path, and the temperature measurement unit further measures the temperature distribution of the reaction fluid along the second flow path and the third flow path, and the reaction analysis device further identifies the reaction state of the reaction fluid in each of the second flow path and the third flow path based on the reaction parameters obtained from the temperature distribution along the second flow path and the third flow path measured by the temperature measurement unit. Therefore, the reaction analysis system can select the optimal flow path from the first flow path, the second flow path, and the third flow path to carry out a chemical reaction. For example, it is possible to select an optimal flow path from the first flow path, the second flow path, and the third flow path so that the heat exchange efficiency is high enough to prevent side reactions from occurring. high The heat exchange efficiency is such that the reaction state can be identified. low By selecting the flow path, it is possible to specify the reaction state of a desired chemical reaction and obtain a substance produced by that chemical reaction with high purity.

[0013] According to some embodiments, a reaction analysis device includes a control unit that acquires a measurement value of a temperature distribution of a reaction fluid obtained by mixing a plurality of reactants in a mixer along a first flow path through which the reaction fluid flows, identifies a reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid obtained from the measurement value of the temperature distribution, and controls a valve to switch a connection with an outlet of the mixer from the first flow path to a second flow path having a higher heat exchange efficiency than the first flow path.

[0014] In this way, the reaction analysis device determines the reaction state based on reaction parameters obtained from the temperature distribution measured in the first flow path, which has a lower heat exchange efficiency than the second flow path. Therefore, the reaction analysis device can obtain useful reaction parameters from the temperature distribution of the reaction fluid and determine the reaction state of the reaction fluid with high accuracy based on the reaction parameters. Furthermore, the reaction analysis device controls the valve to switch the connection with the mixer outlet from the first flow path to the second flow path, which has a higher heat exchange efficiency, thereby suppressing side reactions and obtaining substances produced by the desired chemical reaction with higher purity.

[0015] According to some embodiments, a reaction analysis method includes a first step in which a control unit of a reaction analysis device acquires a measurement value of a temperature distribution of a reaction fluid obtained by mixing a plurality of reactants in a mixer along a first flow path through which the reaction fluid flows; a second step in which a reaction state of the reaction fluid is identified based on a reaction parameter indicating the reaction state of the reaction fluid obtained from the measurement value of the temperature distribution; and a third step in which a valve is controlled to switch a connection with an outlet of the mixer from the first flow path to a second flow path having a higher heat exchange efficiency than the first flow path.

[0016] In this way, the reaction analysis method identifies the reaction state based on reaction parameters obtained from the temperature distribution measured in the first flow path, which has a lower heat exchange efficiency than the second flow path. Therefore, the reaction analysis method can obtain useful reaction parameters from the temperature distribution of the reaction fluid and identify the reaction state of the reaction fluid with high accuracy based on the reaction parameters. Furthermore, the reaction analysis method controls the valve to switch the connection with the mixer outlet from the first flow path to the second flow path, which has a higher heat exchange efficiency, thereby suppressing side reactions and enabling the substance produced by the desired chemical reaction to be obtained with higher purity. [Effects of the Invention]

[0017] According to one embodiment of the present disclosure, it is possible to identify the reaction state of a desired chemical reaction, while obtaining a substance produced by the chemical reaction with higher purity. [Brief explanation of the drawings]

[0018] [Figure 1] FIG. 1 is a block diagram showing the configuration of a reaction analysis system according to a comparative example. [Figure 2] 1 is a block diagram showing an example of the configuration of a reaction analysis system according to an embodiment. [Figure 3] 1 is a block diagram showing an example of the configuration of a reaction analysis device according to an embodiment. FIG. [Figure 4] 1 is a flowchart illustrating an example of a processing procedure of a reaction analysis method according to an embodiment. [Figure 5] 1 is a block diagram showing an example of the configuration of a reaction analysis system according to an embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0019] <Comparative Example> 1 is a block diagram showing the configuration of a reaction analysis system 9 according to a comparative example. The reaction analysis system 9 includes a flow reactor 90, a temperature regulator 95, a temperature measurement unit 96, and a reaction analysis device 98.

[0020] The flow reactor 90 is a flow path through which reactants to be subjected to a chemical reaction are supplied to cause the chemical reaction. The flow reactor 90 includes pumps 91 and 92, liquid feed pipes 911 and 912, a mixer 93, and a reaction tube 94. The pump 91 is connected to a first inlet of the mixer 93 via the liquid feed pipe 911. The pump 92 is connected to a second inlet of the mixer 93 via the liquid feed pipe 912. The mixer 93 includes two inlets and one outlet. The outlet of the mixer 93 is connected to the reaction tube 94 through which a reaction fluid obtained by mixing multiple reactants flows. In this configuration, the pump 91 sends a first reactant to the reaction tube 94 via the liquid feed pipe 911. The pump 92 sends a second reactant to the reaction tube 94 via the liquid feed pipe 912. The first reactant and the second reactant are mixed in the mixer 93, and a chemical reaction begins. The mixture of the first and second reactants flows through the reaction tube 94, during which a chemical reaction takes place.

[0021] The temperature regulator 95 adjusts the temperatures of the mixer 93 and the reaction tube 94 to predetermined temperatures under the control of the reaction analyzer 98 .

[0022] The temperature measuring unit 96 is a device for measuring the temperatures of the reactants and reaction fluid, and includes temperature sensors 961 to 964 for measuring the temperatures at a plurality of positions p0 to p3 in the liquid sending pipe 911 and the reaction tube 94.

[0023] The reaction analysis device 98 controls the operations of the pumps 91 and 92, the temperature regulator 95, etc. Furthermore, the reaction analysis device 98 acquires reaction parameters from the temperature distribution of the reaction fluid measured by the temperature measurement unit 96, and identifies the reaction state of the reaction fluid based on the reaction parameters.

[0024] In the comparative example configuration described above, when the temperature of the reaction fluid in the flow reactor 90 increases, side reactions are more likely to occur. As a result, in the reaction tube 94, not only the reaction fluid with a specific reaction state but also substances produced by side reactions are mixed with the reaction fluid, making it difficult to obtain only the substance produced by the desired chemical reaction with high purity. To address this issue, one possible measure to prevent the temperature rise of the reaction fluid would be to construct the reaction tube 94 from a material that is easily heat-exchanged. However, while making the material more easily heat-exchanged suppresses side reactions, it also makes it difficult to increase the temperature of the reaction fluid, making it difficult to measure the temperature distribution due to the heat of reaction. As a result, it becomes difficult to obtain reaction parameters from the temperature distribution of the reaction fluid and accurately determine the reaction state of the reaction fluid based on those reaction parameters.

[0025] Therefore, an object of the present disclosure is to enable the reaction state of a desired chemical reaction to be specified while enabling the substance produced by that chemical reaction to be obtained with higher purity.

[0026] First Embodiment Hereinafter, an embodiment of the present disclosure will be described with reference to the drawings. In each drawing, parts having the same configuration or function are denoted by the same reference numerals. In the description of this embodiment, duplicated descriptions of the same parts may be omitted or simplified as appropriate.

[0027] The reaction analysis system according to the present disclosure measures temperature changes due to reaction heat while suppressing side reactions by switching between two reaction tubes with different heat exchange efficiencies. Specifically, the reaction analysis system according to the present disclosure measures the reaction fluid in the flow channel of the flow reactor with a temperature sensor and performs reaction analysis based on the temperature distribution of the reaction fluid. Furthermore, the reaction analysis system includes a mechanism for switching the flow channel according to the desired chemical reaction and the purpose of temperature measurement. The reaction analysis system makes it easier to measure temperature changes due to reaction heat by reducing heat exchange in one flow channel. The reaction analysis system also makes it easier to increase heat exchange in the other flow channel, thereby suppressing temperature increases in the reaction fluid and suppressing side reactions. Therefore, the configuration according to the present disclosure makes it possible to identify the reaction state of a desired chemical reaction while obtaining a substance produced by that chemical reaction with a higher purity.

[0028] (Reaction analysis system) 2 is a block diagram showing an example of the configuration of a reaction analysis system 1a according to one embodiment. The reaction analysis system 1a includes pumps 11 and 12, liquid supply pipes 111 and 112, a mixer 13, reaction tubes 14 and 17, a temperature regulator 15, a fluid tank 151, a temperature measurement unit 16, a valve 18, a pump 19, an inlet pipe 191, an outlet pipe 192, and a reaction analysis device 20.

[0029] The pump 11 and the liquid supply pipe 111, as well as the pump 12 and the liquid supply pipe 112, form a plurality of supply flow paths that supply a plurality of reactants to be used in a chemical reaction. The mixer 13 is connected to these plurality of supply flow paths to mix the plurality of reactants. The pump 11 is connected to a first inlet of the mixer 13 via the liquid supply pipe 111. The pump 12 is connected to a second inlet of the mixer 13 via the liquid supply pipe 112. In the example of FIG. 2, the mixer 13 has two inlets and one outlet. Note that the reaction analysis system 1a may have three or more liquid supply pipes, and the mixer 13 may be connected to these three or more supply flow paths to mix three or more types of reactants.

[0030] In this embodiment, the plurality of reactants supplied from the liquid supply pipes 111 and 112 and the reaction fluid sent from the mixer 13 to the reaction tubes 14 and 17 may be liquid, gas, a mixture of liquid and gas, or a mixture of these with a trace amount of solid.

[0031] The reaction analysis system 1a is provided with a valve 18 at the outlet of the mixer 13. A reaction tube 14 as a first flow path and a reaction tube 17 as a second flow path are connected to the valve 18. The valve 18 switches the flow path of the reaction fluid obtained by mixing multiple reactants in the mixer 13 between the reaction tube 14 and the reaction tube 17. In this configuration, the pump 11 sends the first reactant to the mixer 13 via the liquid feed tube 111. The pump 12 sends the second reactant to the mixer 13 via the liquid feed tube 112. The first reactant and the second reactant are mixed in the mixer 13, and a chemical reaction begins. The mixture of the first and second reactants flows through the reaction tube 14 or the reaction tube 17 depending on the state of the valve 18, and the chemical reaction progresses during this process. In this embodiment, the valve 18 switches the discharge destination of the plurality of reactants mixed in the mixer 13 between two reaction tubes (the reaction tube 14 and the reaction tube 17), but may switch the discharge destination between three or more reaction tubes. The reaction tube 17 forms a flow path with higher heat exchange efficiency than the reaction tube 14. For example, the reaction tube 17 is made of a material with higher heat exchange efficiency than the material constituting the reaction tube 14.

[0032] The temperature measurement unit 16 is a device for measuring the temperatures of the reactants and the reaction fluid. In the example of Fig. 2, the temperature measurement unit 16 includes a plurality of temperature sensors 160 to 163 arranged along the flow path before and after the mixer 13. The temperature sensor 160 is installed on the input side of the mixer 13, for example, at position p0 of the liquid feed pipe 111. The temperature sensor 160 can measure or estimate the initial temperature of the reaction fluid obtained by mixing a plurality of reactants (the temperature of the reaction fluid at the outlet of the mixer 13).

[0033] The temperature sensors 161 to 163 are installed at a plurality of positions p1 to p3 in the reaction tube 14, which is one of the output sides of the mixer 13. These temperature sensors 161 to 163 can measure the temperature (temperature distribution) of the reaction fluid immediately after mixing (immediately after the start of the reaction) in the flow direction of the reaction fluid. Note that "immediately after the start of the reaction" does not mean immediately after the reaction fluid actually starts, but means immediately after the reaction fluid is placed in a state where the reaction starts (for example, immediately after a plurality of reactants are mixed). Note that, although the temperature measurement unit 16 in FIG. 2 includes four temperature sensors 160 to 163, the number of temperature sensors included in the temperature measurement unit 16 may be three or less or five or more.

[0034] The temperature regulator 15 adjusts the temperatures of the mixer 13 and the reaction tubes 14 and 17 to predetermined temperatures under the control of the reaction analysis device 20. The temperature regulator 15 may include, for example, a heater or a cooler. The liquid feed pipes 111 and 112, the mixer 13, and the reaction tubes 14 and 17 are installed inside the temperature regulator 15. In the fluid tank 151 inside the temperature regulator 15, the reaction tubes 14 and 17 may be immersed in a temperature-regulating fluid, which is a fluid for regulating the temperature. Such a temperature-regulating fluid may be, for example, a liquid, a gas, a mixture of a liquid and a gas, or a mixture of these with fine solid particles.

[0035] The pump 19 is a pump that sends out a temperature control fluid from the outside of the temperature regulator 15 to the fluid tank 151 inside via an inlet pipe 191. The temperature control fluid sent to the fluid tank 151 is discharged to the outside of the temperature regulator 15 through an outlet pipe 192. The inlet pipe 191 and the outlet pipe 192 may be connected to circulate the temperature control fluid moving inside the temperature regulator 15. The pump 19 can adjust the amount of the temperature control fluid per unit time that flows from the outside of the temperature regulator 15 to the inside of the temperature regulator 15. When the amount of the temperature control fluid flowing into the temperature regulator 15 is large, heat exchange in the reaction tube 14 and the reaction tube 17 is promoted. As described above, the heat exchange efficiency of the reaction tube 17 is higher than that of the reaction tube 14. Therefore, when the inflow and outflow amounts of the temperature control fluid are large, heat exchange in the reaction tube 17 is more advanced than that in the reaction tube 14. Therefore, by adjusting the inflow and outflow rates of the temperature control fluid with the pump 19, it is possible to finely adjust the heat exchange in the reaction tubes 14 and 17.

[0036] In this embodiment, in the temperature controller 15, the reaction tubes 14 and 17 are immersed in the temperature control fluid in the same fluid tank 151. However, a fluid tank for immersing the reaction tube 14 in the temperature control fluid and a fluid tank for immersing the reaction tube 17 in the temperature control fluid may be provided separately. In this case, the type of the temperature control fluid in which the reaction tubes 14 and 17 are immersed may be different for each reaction tube 14 and 17 (for each fluid tank). For example, the temperature control fluid in which the reaction tube 17 is immersed may be made of a material having a higher heat exchange efficiency than the temperature control fluid in which the reaction tube 14 is immersed. Alternatively, a pump 19 for pumping the temperature control fluid may be provided for each reaction tube 14 and 17 (for each fluid tank), and the speed of the pump 19 may be adjusted for each reaction tube 14 and 17. Furthermore, the reaction analysis system 1a may include a stirrer for stirring the temperature control fluid in the fluid tank 151 instead of or together with the pump 19. The stirrer may be, for example, a stirring blade having multiple blades. When the rotation speed of such a stirrer increases, the heat exchange between the temperature control fluid and the reaction tube 14 and the reaction tube 17 is promoted. Therefore, the reaction analysis system 1a can finely adjust the heat exchange in the reaction tube 14 and the reaction tube 17 by adjusting the rotation speed of such a stirrer.

[0037] The reaction analysis device 20 controls the operations of the pumps 11, 12, 19, the temperature regulator 15, etc. Furthermore, the reaction analysis device 20 acquires reaction parameters from the temperature distribution of the reaction fluid measured by the temperature measurement unit 16, and identifies the reaction state of the reaction fluid based on the reaction parameters. The reaction analysis device 20 according to this embodiment is configured by a dedicated information processing device, but may also be configured by a general-purpose information processing device such as a PC (Personal Computer) or a WS (Workstation).

[0038] Here, the reaction parameter is a parameter indicating the reaction state of the reaction fluid. The reaction parameter may be, for example, a first reaction parameter related to the peak value of the temperature distribution of the reaction fluid immediately after the start of the reaction, or a second reaction parameter related to the peak position of the temperature distribution of the reaction fluid immediately after the start of the reaction. Specifically, the first reaction parameter may be, for example, the reaction molar enthalpy (kJ / mol), which indicates the amount of heat generated per unit amount of substance. The second reaction parameter may be, for example, the activation free energy (kJ / mol). The activation free energy is the difference in free energy between the pre-reaction state and the reaction transition state, and indicates the temperature dependence of the reaction rate. Based on these reaction parameters, the reaction analysis device 20 may calculate at least one of the reaction rate of the reaction fluid, the concentrations of multiple reactants, and the concentration or yield of the product contained in the reaction fluid as the reaction state of the reaction fluid. The reaction parameters and reaction state may be values ​​similar to those described in Patent Document 1, for example.

[0039] As described above, the reaction analysis system 1 includes the reaction tubes 14 and 17 with different heat exchange efficiencies as a flow path through which a reaction fluid obtained by mixing a plurality of reactants flows. Here, the reaction analysis device 20 can identify the reaction state of the reaction fluid with high accuracy by measuring the temperature distribution of the reaction fluid along the reaction tube 14 with low heat exchange efficiency. In addition, the reaction analysis device 20 also includes the reaction tube 17 with higher heat exchange efficiency than the reaction tube 14 and a smaller temperature rise due to the chemical reaction, thereby suppressing side reactions and enabling the production of a substance produced by a desired chemical reaction with higher purity.

[0040] (Reaction analysis equipment) 3 is a block diagram showing an example of the configuration of a reaction analysis device 20 according to one embodiment. As shown in FIG. 2, the reaction analysis device 20 includes a control unit 21, a storage unit 22, a communication unit 23, an input unit 24, and an output unit 25.

[0041] The control unit 21 includes one or more processors. In one embodiment, the "processor" may be, but is not limited to, a general-purpose processor or a dedicated processor specialized for a specific process. The control unit 21 is communicably connected to each component of the reaction analysis apparatus 20 and controls the operation of the reaction analysis apparatus 20 as a whole.

[0042] The storage unit 22 includes any storage module including a hard disk drive (HDD), a solid state drive (SSD), a read-only memory (ROM), and a random access memory (RAM). The storage unit 22 may function as, for example, a main storage device, an auxiliary storage device, or a cache memory. The storage unit 22 stores any information used in the operation of the reaction analysis device 20. For example, the storage unit 22 may store a system program, an application program, a temperature distribution measured by the temperature measurement unit 16, reaction parameters derived from the temperature distribution, and various information received by the communication unit 23.

[0043] The communication unit 23 includes any communication module that can be connected to other devices such as the pumps 11, 12, and 19, the temperature measurement unit 16, and the valve 18 using any communication technology. The communication unit 23 may further include a communication control module for controlling communication with other devices, and a storage module for storing communication data such as identification information required for communication with other devices.

[0044] The input unit 24 includes one or more input interfaces that accept input operations from a user and acquire input information based on the user's operations. For example, the input unit 24 may be, but is not limited to, a physical key or a pointing device. The reaction analysis device 20 does not necessarily have to include the input unit 24.

[0045] The output unit 25 includes one or more output interfaces that output information to the user and notify the user. For example, the output unit 25 is a display that outputs information as an image, or a speaker that outputs information as sound, but is not limited to these. At least one of the input unit 24 and the output unit 25 may be configured integrally with the reaction analysis device 20, or may be provided separately. Furthermore, the reaction analysis device 20 does not necessarily have to include the output unit 25.

[0046] The functions of the reaction analysis apparatus 20 can be realized by executing a computer program (program) according to this embodiment on a processor included in the control unit 21. That is, the functions of the reaction analysis apparatus 20 can be realized by software. The computer program causes a computer to execute the processing of steps included in the operation of the reaction analysis apparatus 20, thereby causing the computer to realize functions corresponding to the processing of each step. That is, the computer program is a program for causing a computer to function as the reaction analysis apparatus 20 according to this embodiment.

[0047] Some or all of the functions of the reaction analysis device 20 may be realized by a dedicated circuit included in the control unit 21. That is, some or all of the functions of the reaction analysis device 20 may be realized by hardware. Furthermore, the reaction analysis device 20 may be realized by a single information processing device, or may be realized by the cooperation of multiple information processing devices.

[0048] (Reaction analysis method) 4 is a flowchart showing an example of the processing procedure of a reaction analysis method according to one embodiment. The operation of the reaction analysis apparatus 20 described with reference to FIG. 4 may correspond to at least a part of the reaction analysis method according to this embodiment. Each step in FIG. 4 is executed under the control of the control unit 21 of the reaction analysis apparatus 20. The following processing starts with the valve 18 set so that the reaction fluid mixed in the mixer 13 flows into the reaction tube 14.

[0049] In step S1, the control unit 21 controls the pump 11 to send a first reactant to the liquid feed pipe 111. In parallel with this, the control unit 21 controls the pump 12 to send a second reactant to the liquid feed pipe 112. As a result, the reactants sent from the liquid feed pipes 111 and 112 are mixed in the mixer 13, and a chemical reaction begins. The reaction fluid mixed in the mixer 13 passes through the valve 18 and flows into the reaction tube 14.

[0050] In step S2, the control unit 21 measures the temperatures at position p0 on the input side of the mixer 13 and at each of a plurality of positions p1 to p3 in the reaction tube 14 as the first flow path using the temperature measurement unit 16. The temperature measurement unit 16 outputs the measured temperature values ​​at positions p0 to p3 to the reaction analysis device 20. The control unit 21 of the reaction analysis device 20 acquires the measured temperature values ​​at positions p0 to p3.

[0051] In step S3, the control unit 21 analyzes reaction parameters based on the measured temperature distribution in the flow channel (reaction tube 14) measured in step S2.

[0052] In step S4, based on the analysis results of the reaction parameters analyzed in step S3, control unit 21 sets the temperature of the reaction field using temperature regulator 15. Specifically, for example, control unit 21 may set the temperature of the reaction field to a higher temperature when it is necessary to further promote the chemical reaction, or may set the temperature of the reaction field to a lower temperature when it is necessary to further suppress the chemical reaction.

[0053] In step S5, the control unit 21 controls the valve 18 to switch the flow path so that the reaction fluid mixed in the mixer 13 flows into the reaction tube 17 as a second flow path. The reaction fluid sent from the liquid sending pipes 111 and 112 and mixed in the mixer 13 starts a chemical reaction and flows into the reaction tube 17. Since the reaction tube 17 is more susceptible to heat exchange than the reaction tube 14, the temperature rise of the reaction fluid due to the heat of reaction is suppressed in the reaction tube 17. As a result, since the temperature of the reaction fluid does not rise, side reactions can be suppressed in the reaction tube 17, and only the desired chemical reaction can proceed. Therefore, in the reaction tube 17, it is possible to obtain a substance produced by the desired chemical reaction with higher purity.

[0054] As described above, the reaction analysis system 1a includes the reaction tubes 14 and 17, the temperature measurement units 16 (160 to 163), and the reaction analysis device 20. A reaction fluid obtained by mixing a plurality of reactants in the mixer 13 flows through the reaction tube 14. The reaction fluid obtained in the mixer 13 flows through the reaction tube 17, which has a higher heat exchange efficiency than the reaction tube 14. The temperature measurement units 16 (160 to 163) measure the temperature distribution of the reaction fluid along the reaction tube 14. The reaction analysis device 20 identifies the reaction state of the reaction fluid based on reaction parameters indicating the reaction state of the reaction fluid obtained from the temperature distribution measured by the temperature measurement units 16 (160 to 163).

[0055] In this way, the reaction analysis system 1a identifies the reaction state based on reaction parameters obtained from the temperature distribution measured in the reaction tube 14, which has a lower heat exchange efficiency than the reaction tube 17. Therefore, the reaction analysis system 1a can acquire useful reaction parameters from the temperature distribution of the reaction fluid and identify the reaction state of the reaction fluid with high accuracy based on the reaction parameters. Furthermore, since the reaction analysis system 1a includes the reaction tube 17, which has a higher heat exchange efficiency than the reaction tube 14, it can prevent temperature increases and suppress side reactions. Therefore, the reaction analysis system 1a can identify the reaction state of a desired chemical reaction while obtaining a substance produced by the chemical reaction with a higher purity.

[0056] Furthermore, by further including the valve 18, the reaction analysis system 1a can identify reaction conditions under which a desired chemical reaction can be carried out based on the reaction state corresponding to the temperature distribution of the reaction fluid along the first flow path, and by carrying out the chemical reaction under those conditions, it is possible to obtain a desired substance with high purity from the second flow path. Note that, although an example of a configuration in which the reaction analysis system 1a includes the valve 18 has been described in this embodiment, the reaction analysis system 1a does not necessarily have to include the valve 18. In this case, the reaction fluid obtained in the mixer 13 will flow in parallel through both the reaction tube 14 and the reaction tube 17.

[0057] Furthermore, the reaction analysis system 1a may further include a temperature regulator 15 that adjusts the temperatures of the reaction tubes 14 and 17. Therefore, the reaction analysis system 1a can optimize the temperature as a reaction condition under which a desired chemical reaction can be carried out.

[0058] The reaction analysis system 1a may further include a fluid tank 151 for immersing at least one of the reaction tube 14 and the reaction tube 17 in a temperature control fluid, and a pump 19 for pumping the temperature control fluid from the outside to the inside of the fluid tank 151. Therefore, according to the reaction analysis system 1a, by adjusting the inflow / outflow rate of the temperature control fluid in the fluid tank 151, it is possible to adjust the heat exchange efficiency of at least one of the reaction tube 14 and the reaction tube 17.

[0059] Furthermore, the control unit 21 of the reaction analysis device 20 acquires a measurement value of the temperature distribution of the reaction fluid along the reaction tube 14 through which the reaction fluid obtained by mixing the multiple reactants in the mixer 13 flows. The control unit 21 identifies the reaction state of the reaction fluid based on a reaction parameter indicating the reaction state of the reaction fluid obtained from the measurement value of the temperature distribution. The control unit 21 controls the valve 18 to switch the connection of the outlet of the mixer 13 from the reaction tube 14 to the reaction tube 17, which has a higher heat exchange efficiency than the reaction tube 14.

[0060] In this way, the reaction analysis device 20 identifies the reaction state based on reaction parameters obtained from the temperature distribution measured in the reaction tube 14, which has a lower heat exchange efficiency than the reaction tube 17. Therefore, the reaction analysis device 20 can obtain useful reaction parameters from the temperature distribution of the reaction fluid and identify the reaction state of the reaction fluid with high accuracy based on the reaction parameters. Furthermore, the reaction analysis device 20 controls the valve 18 to switch the connection of the outlet of the mixer 13 from the reaction tube 14 to the reaction tube 17, which has a higher heat exchange efficiency, thereby suppressing side reactions and enabling the substance produced by the desired chemical reaction to be obtained with higher purity.

[0061] In the reaction analysis system 1a, the temperature measurement unit 16 may measure not only the temperature distribution of the reaction fluid along the reaction tube 14 but also the temperature distribution of the reaction fluid along the reaction tube 17. With such a configuration, it is possible to identify not only the reaction state of the reaction fluid along the reaction tube 14 but also the reaction state of the reaction fluid along the reaction tube 17.

[0062] Second Embodiment In the first embodiment, an example of a reaction analysis system 1a has been described with reference to FIG. 2, in which two reaction tubes 14 and 17 are provided and the temperature measurement unit 16 measures the temperature distribution of the reaction fluid along the reaction tube 14. However, the reaction analysis system 1 may be provided with three or more reaction tubes each having a different thermal conductivity. Alternatively, the temperature measurement unit 16 may measure the temperature distribution of the reaction fluid along two or more reaction tubes having different thermal conductivities and identify the reaction state based on the reaction parameters for each reaction tube. In the second embodiment, the configuration of a reaction analysis system 1b, which is one such example, will be described. Components common to the first embodiment are designated by common reference numerals, and detailed description thereof will be omitted.

[0063] 5 is a block diagram showing an example of the configuration of a reaction analysis system 1b according to one embodiment. The reaction analysis system 1b includes pumps 11 and 12, liquid supply pipes 111 and 112, mixers 13 (13a, 13b, and 13c), reaction tubes 14 (14a, 14b, and 14c), a temperature regulator 15, a fluid tank 151, temperature measurement units 16 (161a to 163a, 161b to 163b, and 161c to 163c), valves 18 (18a, 18b, and 18c), a pump 19, an inlet pipe 191, an outlet pipe 192, and a reaction analysis device 20.

[0064] In this configuration, the reaction tubes 14a, 14b, and 14c have different thermal conductivities. Hereinafter, a case will be described in which the thermal conductivity of the reaction tube 14b serving as the second flow path is higher than that of the reaction tube 14a serving as the first flow path, and the thermal conductivity of the reaction tube 14c serving as the third flow path is higher than that of the reaction tube 14b serving as the second flow path. The temperature sensors 161a, 162a, and 163a measure the temperature distribution of the reaction fluid along the flow path of the reaction tube 14a. The temperature sensors 161b, 162b, and 163b measure the temperature distribution of the reaction fluid along the flow path of the reaction tube 14b. The temperature sensors 161c, 162c, and 163c measure the temperature distribution of the reaction fluid along the flow path of the reaction tube 14c.

[0065] Each of the valves 18a, 18b, and 18c is configured to allow the inflow of reactants from the liquid sending pipe 111 side and the inflow of reactants from the liquid sending pipe 112 side. Therefore, the mixers 13a to 13c function similarly to the mixer 13 of the reaction analysis system 1a according to the first embodiment. Each of the valves 18a, 18b, and 18c is provided on the reaction tubes 14a, 14b, and 14c side, and the outflow to the reaction tubes 14a, 14b, and 14c is switched by opening and closing the valve. When any of the valves 18a, 18b, and 18c is opened on the reaction tubes 14a, 14b, and 14c side, the reaction fluid flows into the reaction tube connected to that valve. For example, when the valves 18a and 18b are closed to the reaction tubes 14a and 14b and the valve 18c is open to the reaction tube 14c, the reactants from the liquid feed tubes 111 and 112 are mixed in the mixer 13c, and the reaction fluid flows to the reaction tube 14c. Similarly, when the valves 18a and 18c are closed to the reaction tubes 14a and 14c and the valve 18b is open to the reaction tube 14b, the reaction fluid flows from the mixer 13b to the reaction tube 14b. When the valves 18b and 18c are closed to the reaction tubes 14b and 14c and the valve 18a is open to the reaction tube 14a, the reaction fluid flows from the mixer 13a to the reaction tube 14a.

[0066] The reaction analysis device 20 can flow the reaction fluid into a desired reaction tube 14 (14a, 14b, 14c) by controlling the opening and closing of such valves 18a, 18b, 18c. As described above, the temperature measurement unit 16 can measure the temperature distribution of the reaction fluid along the flow path of each reaction tube 14 (14a, 14b, 14c), so that the reaction analysis device 20 can identify the reaction state of the reaction fluid for each reaction tube.

[0067] Furthermore, depending on the type of reactants used in a chemical reaction, the reaction analysis device 20 may select a flow path that increases in temperature to a level necessary for the desired chemical reaction to proceed but does not increase in temperature to a level where side reactions become dominant over the desired chemical reaction. In this case, the reaction analysis device 20 may further control the operation of the pump 19 to change the flow rate of the temperature-controlling fluid and adjust the thermal conductivity of the reaction field, thereby adjusting the temperature increase in the selected flow path. The reaction analysis system 1b includes temperature sensors 161 (161a, 161b, 161c) to 163 (163a, 163b, 163c) in all flow paths, thereby suppressing side reactions during synthesis and simultaneously enabling in-line sensing of reaction parameters from the measured temperature distribution. In other words, the reaction analysis system 1b can identify the reaction state of a desired chemical reaction using a single reaction tube while obtaining a substance produced by that chemical reaction with high purity.

[0068] As described above, the reaction analysis system 1b further includes a reaction tube 14c through which the reaction fluid obtained in the mixer 13 (13a, 13b, 13c) flows, and which has a higher heat exchange efficiency than the reaction tube 14b. Furthermore, the reaction analysis system 1b further includes a valve 18 (18a, 18b, 18c) for switching the connection of the outlet of the mixer 13 to the reaction tubes 14a, 14b, 14c. The temperature measurement unit 16 measures the temperature distribution of the reaction fluid not only along the reaction tube 14a but also along the reaction tubes 14b and 14c. The reaction analysis device 20 further identifies the reaction state of the reaction fluid not only in the reaction tube 14a but also in each of the reaction tubes 14b and 14c based on reaction parameters obtained from the temperature distributions along the reaction tubes 14a, 14b, and 14c measured by the temperature measurement unit 16. Therefore, the reaction analysis system can select an optimal flow path from among the reaction tubes 14a, 14b, and 14c to perform a chemical reaction. For example, the heat exchange efficiency is low enough to prevent side reactions from occurring. high The heat exchange efficiency is such that the reaction state can be identified. low By selecting the flow path, it is possible to specify the reaction state of a desired chemical reaction and obtain a substance produced by that chemical reaction with high purity.

[0069] The following additional notes are provided regarding example embodiments of the present disclosure. [1] a first flow path through which a reaction fluid obtained by mixing a plurality of reactants in the mixer flows; a second flow path through which the reaction fluid obtained in the mixer flows, the second flow path having a higher heat exchange efficiency than the first flow path; a temperature measuring unit that measures a temperature distribution of the reaction fluid along the first flow path; a reaction analysis device that identifies a reaction state of the reaction fluid based on a reaction parameter that indicates a reaction state of the reaction fluid obtained from the temperature distribution measured by the temperature measurement unit; and A reaction analysis system comprising:

[0070] [2] The reaction analysis system according to [1], further comprising a temperature regulator that adjusts the temperature of the first flow path and the second flow path.

[0071] [3] a fluid tank for immersing at least one of the first flow path and the second flow path in a temperature control fluid; a pump that pumps the temperature control fluid from the outside to the inside of the fluid tank; The reaction analysis system according to [1] or [2], further comprising:

[0072] [4] The reaction analysis system according to any one of [1] to [3], wherein the temperature measurement unit further measures a temperature distribution of the reaction fluid along the second flow path.

[0073] [5] The reaction analysis system according to any one of [1] to [4], further comprising a valve that switches the connection of the mixer to an outlet between the first flow path and the second flow path.

[0074] [6] a third flow path through which the reaction fluid obtained in the mixer flows, the third flow path having a higher heat exchange efficiency than the second flow path; a valve that switches a connection with an outlet of the mixer among the first flow path, the second flow path, and the third flow path; the temperature measurement unit further measures a temperature distribution of the reaction fluid along the second flow path and the third flow path; the reaction analysis device further identifies a reaction state of the reaction fluid in each of the second flow path and the third flow path based on the reaction parameters obtained from the temperature distributions along the second flow path and the third flow path measured by the temperature measurement unit. [1] to [3], the reaction analysis system according to any one of [1] to [3].

[0075] [7] obtaining a measurement value of a temperature distribution of a reaction fluid obtained by mixing a plurality of reactants in a mixer along a first flow path through which the reaction fluid flows; Identifying a reaction state of the reaction fluid based on a reaction parameter indicating a reaction state of the reaction fluid obtained from the measurement value of the temperature distribution; controlling a valve to switch the connection with the outlet of the mixer from the first flow path to a second flow path having a higher heat exchange efficiency than the first flow path; A reaction analysis device comprising a control unit.

[0076] [8] The control unit of the reaction analysis device a first step of acquiring a measurement value of a temperature distribution of a reaction fluid obtained by mixing a plurality of reactants in a mixer along a first flow path through which the reaction fluid flows; a second step of identifying a reaction state of the reaction fluid based on a reaction parameter indicating a reaction state of the reaction fluid obtained from the measurement value of the temperature distribution; a third step of controlling a valve to switch the connection of the mixer to an outlet port from the first flow path to a second flow path having a higher heat exchange efficiency than the first flow path; A reaction analysis method comprising:

[0077] The present disclosure is not limited to the above-described embodiments. For example, multiple blocks shown in the block diagrams may be integrated, or one block may be divided. Multiple steps shown in the flowcharts may be executed in parallel or in a different order depending on the processing capabilities of the device executing each step, or as needed, instead of being executed in chronological order as described. Other modifications are possible without departing from the spirit of the present disclosure. [Explanation of symbols]

[0078] 1a,1b Reaction analysis system 11,12 Pump 111,112 Liquid delivery pipe 13 Mixer 14,17 Reaction tube 15 Temperature regulator 151 Fluid tank 16 Temperature measurement part 160~163 Temperature sensor 18 valves 19 Temperature-controlled fluid delivery pump 191 Inflow pipe 192 Discharge pipe 20 Reaction analysis device 21 Control section 22 Memory section 23 Communications Department 24 Input section 25 Output section 9. Reaction Analysis System 90 Flow Reactor 91,92 Pump 911,912 Liquid transport pipe 93 Mixer 94 Reaction tube 95 Temperature regulator 96 Temperature measurement section 961~964 Temperature Sensor 98 Reaction Analysis Device

Claims

1. a first flow path connected to a mixer that mixes a plurality of reactants to obtain a reaction fluid, the first flow path through which the reaction fluid flows while reacting; a second flow path connected to the mixer, through which the reaction fluid flows while reacting; a temperature measuring unit that measures a temperature distribution of the reaction fluid along the first flow path; a reaction analysis device that identifies a reaction state of the reaction fluid based on a reaction parameter that indicates a reaction state of the reaction fluid obtained from the temperature distribution measured by the temperature measurement unit; and Equipped with a heat exchange efficiency between the reaction fluid flowing through the second flow path and the temperature control fluid outside the second flow path is higher than a heat exchange efficiency between the reaction fluid flowing through the first flow path and the temperature control fluid outside the first flow path; Reaction analysis system.

2. a temperature regulator having a fluid tank for containing the temperature control fluid; the first flow path and the second flow path are immersed in the temperature regulating fluid in the fluid tank; The reaction analysis system according to claim 1 .

3. a fluid tank for immersing at least one of the first flow path and the second flow path in a temperature control fluid; a pump that pumps the temperature control fluid from the outside to the inside of the fluid tank; The reaction analysis system according to claim 1 , further comprising:

4. The reaction analysis system according to claim 1 , wherein the temperature measurement unit further measures a temperature distribution of the reaction fluid along the second flow path.

5. The reaction analysis system according to claim 1 , further comprising a valve that switches a connection between the outlet of the mixer and the first flow path and the second flow path.

6. a third flow path connected to the mixer, through which the reaction fluid flows while reacting; a valve that switches a connection between the outlet of the mixer and the first flow path, the second flow path, and the third flow path; a heat exchange efficiency between the reaction fluid flowing through the third flow path and the temperature control fluid outside the third flow path is higher than a heat exchange efficiency between the reaction fluid flowing through the second flow path and the temperature control fluid outside the second flow path; the temperature measurement unit further measures a temperature distribution of the reaction fluid along the second flow path and the third flow path; the reaction analysis device further identifies a reaction state of the reaction fluid in each of the second flow path and the third flow path based on the reaction parameters obtained from the temperature distributions along the second flow path and the third flow path measured by the temperature measurement unit. The reaction analysis system according to claim 1 .

7. a first flow path connected to a mixer that mixes a plurality of reactants to obtain a reaction fluid, the first flow path being connected to a mixer through which the reaction fluid flows while reacting, and a measurement value of a temperature distribution of the reaction fluid along the first flow path; identifying a reaction state of the reaction fluid in the first flow path based on a reaction parameter indicating a reaction state of the reaction fluid obtained from the measurement value of the temperature distribution; controlling a valve to switch the connection with the outlet of the mixer from the first flow path to a second flow path through which the reaction fluid flows while reacting; A control unit is provided, a heat exchange efficiency between the reaction fluid flowing through the second flow path and the temperature control fluid outside the second flow path is higher than a heat exchange efficiency between the reaction fluid flowing through the first flow path and the temperature control fluid outside the first flow path; Reaction analysis device.

8. The control unit of the reaction analysis device a first step of acquiring a measurement value of a temperature distribution of a reaction fluid along a first flow path connected to a mixer in which a plurality of reactants are mixed to obtain a reaction fluid, the first flow path being a flow path through which the reaction fluid flows while reacting; a second step of identifying a reaction state of the reaction fluid in the first flow path based on a reaction parameter indicating a reaction state of the reaction fluid obtained from the measurement value of the temperature distribution; a third step of controlling a valve to switch the connection with the outlet of the mixer from the first flow path to a second flow path through which the reaction fluid flows while reacting; A reaction analysis method comprising:

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