Bis-[N-((5-carbamoyl)-1H-benzo[d]imidazole-2-yl)-pyrazole-5-carboxamide] derivatives and related compounds as STING (interferon-stimulating factor) agonists for cancer treatment

Abstract

The present disclosure relates to compounds of formula (IA') as STING (stimulator of interferon genes) agonists for use in the treatment of, for example, cancer, obesity, liver injury, glycolipid metabolism, and viral infections. The synthesis and characterization of exemplary compounds and their pharmacological data are disclosed herein (e.g., pages 128-286; Examples 1-54; Tables 1, 2a, 2b, and 3). An exemplary compound is, for example, Example 1: (E)-N-(5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-7-(3-hydroxypropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-7-methoxy-1H-benzo[d]imidazol-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide (Compound 9). TIFF2022543086000329.tif89128

Description

[Technical Field]

[0001] Related applications This application claims priority and benefits of U.S. Provisional Application No. 62 / 882,081 filed 2 August 2019, U.S. Provisional Application No. 62 / 944,643 filed 6 December 2019, and U.S. Provisional Application No. 62 / 982,935 filed 28 February 2020. The contents of each of these applications are incorporated herein by reference in their entirety. [Background technology]

[0002] background Interferon-stimulating factor (STING) is an endoplasmic reticulum receptor that propagates innate immune sensing of cytosolic pathogen-derived DNA and autologous DNA. STING is a 378-amino acid protein primarily composed of three structural domains: (i) N-terminal transmembrane domain (aa 1-154); (ii) central globular domain (aa 155-341); and (iii) C-terminal chain (aa 342-379). STING can form symmetric dimers that bind to ligands in a V-shaped structure but do not completely enclose the bound ligand. STING agonists can bind to the pocket region of STING. However, in some severe disease conditions, the STING activation process is readily inhibited, leading to inactivation of the STING pathway. Therefore, screening and design of potent STING agonists are crucial for cancer immunotherapy, as well as for the treatment of other infectious diseases, including but not limited to obesity, liver injury, glucose-lipid metabolism, and viral infections. Specific targeting of immune pathways presents an opportunity in cancer treatment, potentially offering greater specificity than cell population-based therapeutic approaches.

[0003] The compounds of the present disclosure modulate STING activity and thus may exhibit beneficial therapeutic effects in the treatment of diseases, disorders, and / or conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, including but not limited to inflammation, allergic and autoimmune diseases, infectious diseases, cancer, and pre-cancerous syndromes, and as vaccine adjuvants.

Summary of the Invention

[0004] Summary In some aspects, the present disclosure provides a compound of formula (IA'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000001.tif79128 wherein, W1, X1, Y1, Z1, W2, X2, Y2, and Z2 are each independently O, S, C, or N; X3 and X4 are each independently S or NR f ; X5 is N or CR A2 ; X6 is N or CR A1 ; X9 is N or CR 4 ; r and s are each independently 0 or 1; p is 1 or 2; the sum of r and s is 1 or 2; R A1 and R A2 are each independently H, halogen, amino, amino(C 1~4 alkyl)-, hydroxy, -O-P(O)(OH)2, -O-P(O)(R I R II ), -(R e )(R f ), -CO2R f ), -N(R f ), -COR b ), -N(R g ), -SO2(C 1~4 alkyl)-N(R e )(R f), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(RI R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If r is 0, B1 and R B2 Each of these is independently H, and C may be substituted. 1~6 Alkyl, Halo(C) 1~6 C (alkyl), may be substituted. 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 The cycloalkyl group is a substituted or substituted 4-6 member heterocycloalkyl group, a substituted or substituted phenyl group, a substituted or substituted 5-6 member heteroaryl group, or a substituted or substituted 9-10 member heteroaryl group. Here, the C which may be substituted 1~6 Alkyl, possibly substituted C 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 Cycloalkyls, optionally substituted 4-6 member heterocycloalkyls, optionally substituted phenyls, optionally substituted 5-6 member heteroaryls, or optionally substituted 9-10 member heteroaryls may contain halogens, nitros, or -R c , -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R c , -NR c Rd 、 -OCOR c 、 -CO2H, -CO2R c 、 -SOR c 、 -SO2R c 、 -CONH2, -CONR c R d 、 -SO2NH2, -SO2NR c R d 、 -OCONH2, -OCONR c R d 、 -NR d COR c 、 -NR d SOR c 、 -NR d CO2R c 、および -NR[[ID=​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, optionally substituted C 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-, Here, the substitution may be made -C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl-C) 1~4 The alkyl part of alkyl)- is a halogen, halo(C1~4 Alkyl), -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may be substituted with one or two substituents that are selected more independently of each other. The C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, -OP(O)(OR I R II)2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If s is 1, then W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with D, they form a linking group, where D is -halo(C 1~12 Alkyl)-, may be substituted-C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C1~6 Alkyl-, Here, the substitution may be made -C 1~12 Alkyl-, or possibly substituted-C 1~6 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)C 1~6 The alkyl part of alkyl- is a halogen, halo(C) 1~4 Alkyl), -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R cThey may be substituted with one or two substituents that are selected more independently of each other. The substitution may be made -C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, and C 1~4 Alkoxy-(C) 1~4 The alkoxy(-) group may be substituted with 1 to 4 substituents, each independently substituted; R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(Rf ), -CH2N(R d )CO(R f ) or, R 3 and R 5 One of them is -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H, COOH, or -CO2R c and; R 4 and R 6 These are H, halogen, and halo (C) respectively, independently. 1~6 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -OP(O)(OH)2, OP(O)(R I R II )2, -NH2, -NR c R c , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g) SO2(C 1~2 Alkyl)-N(R h )(R f ), -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C1~4 Selected from alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R c , -NR c R d -CO2H, -CO2R c , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may also be substituted with 1 to 4 substituents, each selected independently; R 14 C may be absent, or may be replaced by H, a halogen, or other C atoms. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These, together with one or more atoms connecting them, form a 5-6 membered ring; or, R 16 and R 17 These, together with one or more atoms connecting them, form a 5-6 membered ring; R 18 and R 19 Each of these is independent and either nonexistent, H, halogen, or substituted C. 1~4 The C is alkyl, and here it may be substituted. 1~4 Alkyl is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 17 and R 18 These, together with one or more atoms connecting them, form a 5-6 membered ring; R a H, -R c , -COR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -CH2-CO2R c , or -SO2NRc R d and; Each R b C is independent 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), or -(C 1~4 Alkyl)-CO-O-(C 1~4 Alkyl) is; Each R c H and C are independent of each other. 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), -(C 1~4 Alkyl)-CO-O-(C 1~4 C (alkyl), may be substituted. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 It is an alkyl-9~10 member heteroaryl, Here, the C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 Alkyl-9~10 member heteroaryl C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, 5-6 member heteroaryl moiety, or 9-10 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d, -CON(R d )(R f ), and -CO2R d They may also be substituted with 1 to 4 substituents, each selected independently; Each R d These are independently H, hydroxyl, or C 1~4 It is alkyl; Each R e H and (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -CO2(C 1~4 Alkyl), -(C 1~4 Alkyl)amino, -(C 1~4 Alkyl)-C 1~4 Alkoxy, -CO- (may be substituted 5-6 member heterocycloalkyl), -CO- (C 1~4 Alkyl)-(optionally substituted 5-6 member heterocycloalkyl), -CO-(optionally substituted 5-6 member heteroaryl), -CO-(C 1~4 Alkyl)-(may be substituted 5-6 member heteroaryl), Here, the optionally substituted 5-6 member heterocycloalkyl or optionally substituted 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)OP(O)(OH)2, -(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d, -CON(R d )(R f ), and -CO2R d They may also be substituted with 1 to 4 substituents, each selected independently; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R g and R h Each is independently H or (C 1~4 Alkyl) or R g and R h They, together with one or more atoms connecting them, form a 5-6 membered ring; and Each R I and R II (C 1~6 It is alkyl)oxy-; However, at least one of (i), (ii), or (iii) applies: (i) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S, or X9 is N; or (ii) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, then R 14 is halogen, -OR c , -NR c Rd , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) s is 0 and r is 1, and (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 The alkoxy may be substituted with 1 to 4 substituents, each independently selected.

[0005] In some embodiments, the compound is a compound of formula (IA'), which is formula (IA), or a prodrug, solvate, pharmaceutically acceptable salt thereof, or tautomer: TIFF0007843695000002.tif79128.

[0006] In some embodiments, the compound is a compound of formula (V'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000003.tif75128In formula, Y1, Y2, Z1, and Z2 are each independently O, S, C, or N; X1, X2, W1, and W2 are each independently either C or N; X3 and X4 are independently S or NR f and; X5 is N or CR A2 and; X6 is N or CR A1 and; X9 is N or CH; R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), -CH2N(R d )CO(R f ) or, R 3 and R 5 One of them is -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H, -COOH, or -CO2R C and; R c is C 1~4 It is alkyl; R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, may be substituted (C1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), and may be substituted with 1 to 4 substituents independently selected from the group including -COOH; Each R d These are independently H, hydroxyl, or C 1~4 It is alkyl; R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), and -CO2(C 1~4 Selected from alkyl groups; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R 14 and R C2 Each is independent, either non-existent or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may also be substituted with a more preferred substituent; R 16 and R C1 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl; and R15 , R 17 , R 18 , or R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S, or X9 is N; or (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONRc R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl) or substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), and may be substituted with 1 to 4 substituents independently selected from the group including -COOH.

[0007] In some embodiments, the compound is a compound of formula (V'), which is a compound of formula (V), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000004.tif75128.

[0008] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which this disclosure pertains. Methods and materials similar to or equivalent to those described herein may be used in the implementation or testing of this disclosure, but preferred methods and materials are described below. All publications, patent applications, patents, and other references referenced herein are incorporated by reference in their entirety. In case of any inconsistency, this specification, including definitions, shall prevail. Furthermore, materials, methods, and examples are illustrative only and are not intended to be limiting.

[0009] [Invention 1001] Compounds of formula (IA'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers: TIFF0007843695000005.tif73128 During the ceremony, W 1 、X 1 、Y 1 、Z 1 、W 2 、X 2 、Y 2 , and Z 2 Each of these is independently O, S, C, or N; X 3 and X 4 Each is independently S or NR f and; X 5 is N or CR A2 and; X 6 is N or CR A1 and; X 9 is N or CR 4 and; r and s are independently either 0 or 1; p is either 1 or 2; The sum of r and s is 1 or 2; R A1 and R A2 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-,hydroxy,-OP(O)(OH) 2 , -OP(O)(R I R II ) 2 , -N(R e )(R f ), -CO 2 R f , -N(R f )COR b , -N(R g )SO 2 (C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 、C 1~4 Alkoxy-, -N(R) e )(R f ), -CO 2 (R f ), -CON(R e )(Rf ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH 2 Hello (C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH) 2 、-(C 1~4 Alkyl)-OP(O)(R I R II ) 2 Hello (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH) 2 、-(C 2~4 Alkoxy)-OP(O)(R I R II ) 2 、-C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If r is 0, B1 and R B2 Each of these is independently H, and C may be substituted. 1~6 Alkyl, Halo(C) 1~6 C (alkyl), may be substituted. 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 The cycloalkyl group is a substituted or substituted 4-6 member heterocycloalkyl group, a substituted or substituted phenyl group, a substituted or substituted 5-6 member heteroaryl group, or a substituted or substituted 9-10 member heteroaryl group. Here, the C which may be substituted 1~6 Alkyl, possibly substituted C 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 Cycloalkyls, optionally substituted 4-6 member heterocycloalkyls, optionally substituted phenyls, optionally substituted 5-6 member heteroaryls, or optionally substituted 9-10 member heteroaryls may contain halogens, nitros, or -R c -OH, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -OR c , -NH 2 , -NR c R c , -NR c R d , -OCOR c , -CO 2 H, -CO 2 R c -SOR c , -SO 2 R c ,-CONH 2 ,-CONR c R d , -SO 2 NH 2 , -SO 2 NR c R d ,-OCONH 2 ,-OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO 2 R c , and -NR d SO 2 R c They may also be substituted with 1 to 4 substituents, each selected independently; If s is 0, R C1 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl, RC2 C may not exist or may be replaced. 1~4 Alkyl, where the substituted C 1~4 Alkyl groups are -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; If r is 1, R B1 and R B2 Each is independently -CH 2 - and B is R B1 and R B2 Together with it, it forms a linking group, where B is a bond, or B is a -halo(C 1~10 Alkyl)-, may be substituted-C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, optionally substituted C 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-, Here, the substitution may be made -C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl-C) 1~4 The alkyl part of alkyl)- is a halogen, halo(C 1~4 alkyl), -OH, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -OR c , -NH 2 , -NR c R d , -OCOR c , -CO 2 H, -CO 2 R c -SOR c , -SO 2 R c ,-CONH 2 ,-CONR c R d , -SO 2 NH 2 , -SO 2 NR c R d ,-OCONH 2 ,-OCONR cR d , -NR d COR c , -NR d SOR c , -NR d CO 2 R c , and -NR d SO 2 R c They may be substituted with one or two substituents that are selected more independently of each other. The C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety contains halogens, hydroxyls, and -OP(O)(OH) 2 , -OP(O)(OR I R II ) 2 , amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH) 2 、-(C 2~4 Alkoxy)-OP(O)(R I R II ) 2 , and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If s is 1, W 1 and Z 2 Each is independently either C or N, and R C1 and R C2 Each is independently -CH 2 - and D is R C1 and R C2 Together with D, they form a linking group, where D is -halo(C 1~12 Alkyl)-, may be substituted-C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-, Here, the substitution may be made -C 1~12 Alkyl-, may be substituted- C 1~6 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)C 1~6 The alkyl part of alkyl- is a halogen, halo(C) 1~4 alkyl), -OH, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -OR c , -NH 2 , -NR c R d , -OCOR c , -CO 2 H, -CO 2 R c -SOR c , -SO 2 R c ,-CONH 2 ,-CONR c R d , -SO 2 NH 2 , -SO 2 NR c R d ,-OCONH 2 ,-OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO 2 R c , and -NR d SO 2 R c They may be substituted with one or two substituents that are selected more independently of each other. The substitution may be made -C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety contains halogens, hydroxyls, and -OP(O)(OH) 2 , OP(O)(R I R II ) 2 , amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH) 2 、-(C 2~4 Alkoxy)-OP(O)(R I R II ) 2 , and C 1~4 Alkoxy-(C) 1~4 The alkoxy(-) group may be substituted with 1 to 4 substituents, each independently substituted; R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH 2 N(R d )(R f ), -N(R d )(R f ), -N(Rd )CO(R f ), -CH 2 N(R d )CO(R f ) or, R 3 and R 5 One of them is -CON(R d )(R f ), -CH 2 N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH 2 N(R d )CO(R f ) and R 3 and R 5 The other of these is H, COOH, or -CO 2 R c and; R 4 and R 6 These are H, halogen, and halo (C) respectively, independently. 1~6 Alkyl), Halo (C 1~6 Alkoxy)-,hydroxy,-OP(O)(OH) 2 , OP(O)(R I R II ) 2 , -NH 2 , -NR c R c , -NR c R d , -COR c , -CO 2 R c , -N(R d )CORc , -N(R d )SO 2 R c , -N(R g) SO 2 (C 1~2 Alkyl)-N(R h )(R f ), -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Selected from alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -OR c , -NH 2 , -NR c R c , -NR c R d , -CO 2 H, -CO 2 R c , -OCOR c , -CO 2 H, -CO 2 R c -SOR c , -SO 2 R c ,-CONH 2 ,-CONR c R d , -SO 2 NH 2 , -SO 2 NR c R d ,-OCONH 2 ,-OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO 2 R c , -NR d SO 2 R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl is a halogen, hydroxyl, or -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH) 2 、-(C 1~4 Alkyl)-OP(O)(R I R II ) 2 Hello (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH) 2 、-(C2~4 Alkoxy)-OP(O)(R I R II ) 2 、C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO 2 R d They may also be substituted with 1 to 4 substituents, each selected independently; R 14 C may be absent, or may be replaced by H, a halogen, or other C atoms. 1~4 Alkyl, where the substituted C 1~4 Alkyl is halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR cR d , -SO 2 NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These, together with one or more atoms connecting them, form a 5-6 membered ring; or, R 16 and R 17 These, together with one or more atoms connecting them, form a 5-6 membered ring; R 18 and R 19 Each of these is independent and either nonexistent, H, halogen, or substituted C. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 17 and R 18 These, together with one or more atoms connecting them, form a 5-6 membered ring; R a H, -R c , -COR c , -CO 2 H, -CO 2 R c -SOR c , -SO 2 R c ,-CONH 2 ,-CONR c Rd , -SO 2 NH 2 , -CH 2 -CO 2 R c , or -SO 2 NR c R d and; Each R b C is independent 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH) 2 、-(C 1~4 Alkyl)-OP(O)(R I R II ) 2 、-(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f )、-(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), or -(C 1~4 Alkyl)-CO-O-(C 1~4 Alkyl) is; Each R c H and C are independent of each other. 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH) 2 、-(C 1~4 Alkyl)-OP(O)(R I R II ) 2 、-(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f )、-(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), -(C 1~4 Alkyl)-CO-O-(C 1~4 C (alkyl), may be substituted. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 It is an alkyl-9~10 member heteroaryl, Here, the C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 Alkyl-9~10 member heteroaryl C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, 5-6 member heteroaryl moiety, or 9-10 member heteroaryl moiety contains halogens, hydroxyls, and -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH) 2 、-(C 2~4 Alkoxy)-OP(O)(R I R II ) 2 、C1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO 2 R d They may also be substituted with 1 to 4 substituents, each selected independently; Each R d These are independently H, hydroxyl, or C 1~4 It is alkyl; Each R e H and (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -CO 2 (C 1~4 Alkyl), -(C 1~4 Alkyl)amino, -(C 1~4 Alkyl)-C 1~4 Alkoxy, -CO- (may be substituted 5-6 member heterocycloalkyl), -CO- (C 1~4 Alkyl)-(optionally substituted 5-6 member heterocycloalkyl), -CO-(optionally substituted 5-6 member heteroaryl), -CO-(C 1~4 Alkyl)-(may be substituted 5-6 member heteroaryl), Here, the optionally substituted 5-6 member heterocycloalkyl or optionally substituted 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)OP(O)(OH) 2 、-(C 2~4 Alkoxy)-OP(O)(R I R II ) 2 、C1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO 2 R d They may also be substituted with 1 to 4 substituents, each selected independently; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R g and R h Each is independently H or (C 1~4 Alkyl) or R g and R h They, together with one or more atoms connecting them, form a 5-6 membered ring; and Each R I and R II (C 1~6 It is alkyl)oxy-; However, at least one of (i), (ii), or (iii) applies: (i) s is 0 and r is 1, and (a) Z 1 、Z 2 、Y 1 , and Y 2 Each of these is N, and W 1 、W 2 、X 1 , and X 2 (b) W 1 、W 2 、X 1 , and X 2 Each of these is N, and Z 1 、Z 2 、Y 1 , and Y 2 (c) Z 1 and Y 1 Each of these is N, and W 1 and X 1 (d) Z 2 and Y 2 Each of these is N, and W 2 and X 2 (e) W 1 and X 1 Each of these is N, and Z 1 and Y 1 (f) W 2 and X 2 Each of these is N, and Z 2 and Y 2 If each of them is C, then X 3 and X 4 At least one of them is S, or X 9 is N; or, (ii) s is 0 and r is 1, (a) Z 1 、Z 2 、Y 1 , and Y 2 Each of these is N, and W 1 、W 2 、X 1 , and X 2 (b) W 1 、W 2 、X 1 , and X 2 Each of these is N, and Z 1 、Z 2 、Y 1 , and Y 2 If each of them is C, then R 14 is halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) s is 0 and r is 1, (a) Z 1 and Y 1 Each of these is N, and W 1 and X 1 (b) Z 2 and Y 2 Each of these is N, and W 2 and X 2 (c) W 1 and X 1 Each of these is N, and Z 1 and Y 1 (d) W 2 and X 2 Each of these is N, and Z 2 and Y 2 If each of them is C, then X 5 、X 6 , and X 9 At least one of them is N, and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -N(R e )(R f ), -CO 2 (R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH 2 Hello (C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH) 2 、-(C 1~4 Alkyl)-OP(O)(R I R II ) 2 Hello (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH) 2 、-(C 2~4 Alkoxy)-OP(O)(R I R II ) 2 、-C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents. [Invention 1002] If s is 0 and r is 1, then X 3 and X 4 At least one of them is S, or X 5 、X 6 , and X 9 A compound of the present invention 1001, wherein at least one of the elements is N. [Invention 1003] A compound of any of the present inventions, which is formula (IA), or its prodrug, solvate, pharmaceutically acceptable salt, or tautomer: TIFF0007843695000006.tif73128 。 [Invention 1004] Compounds of formula (I'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers: TIFF0007843695000007.tif73128 During the ceremony, W 1 、X 1 、Y 1 、Z 1 、W 2 、X 2 、Y 2 、Z 2 ,r,s,X 3 、X 4 、X 5 、X 6 、X 9 、R 3 、R 5 、R 14 、R a 、R b 、R c 、R d 、R e 、Rf 、R I , and R II Each of these is defined independently for equation (IA'); If r is 0, B1 and R B2 Each of these is defined independently for equation (IA'); If s is 0, R C1 This is defined for equation (IA'); If r is 1, R B1 and R B2 Each is independently -CH 2 - and B is R B1 and R B2 Together with it, they form a linking group, where B is a bond, or B is as defined for formula (IA'); If s is 1, W 1 and Z 2 Each is independently either C or N, and R C1 and R C2 Each is independently -CH 2 - and D is R C1 and R C2 Together with it, they form a linking group, where D is as defined for formula (IA'); R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c Rd It may be substituted with a more preferred substituent; or, R 15 and R 19 These, together with one or more atoms connecting them, form a 5-6 membered ring; R 18 and R 19 Each is independent, as defined for equation (IA'); or R 17 and R 18 These, together with one or more atoms connecting them, form a 5-6 membered ring; R g and R h Each is independent, as defined for equation (IA'); or R g and R h These, together with one or more atoms connecting them, form a 5-6 membered ring; However, at least one of (i), (ii), or (iii) of formula (IA') applies. [Invention 1005] A compound of any of the present inventions, which is formula (I), or its prodrug, solvate, pharmaceutically acceptable salt, or tautomer: TIFF0007843695000008.tif73128 。 [Invention 1006] Any compound of the present invention, which is a compound of formula (V'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000009.tif69128 During the ceremony, Y 1 、Y 2 、Z 1 , and Z 2 Each of these is independently O, S, C, or N; X 1 、X 2 、W 1 , and W 2 Each is independently either C or N; X 3 and X 4 Each is independently S or NR f and; X 5 is N or CR A2 and; X 6 is N or CR A1 and; X 9 is N or CH; R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH 2 N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), -CH 2 N(R d )CO(R f ) or R 3 and R 5 One of them is -CON(R d )(R f ), -CH 2 N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH 2 N(R d )CO(R f ) and R 3 and R 5 The other of these is H, -COOH, or -CO 2 R C and; R c is C 1~4 It is alkyl; R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, C 1~4 Alkoxyl, -N(R e )(R f ), -CO 2 (R f ), -CON(R e )(R f ), and may be substituted with 1 to 4 substituents independently selected from the group including -COOH; Each R d These are independently H, hydroxyl, or C 1~4 It is alkyl; R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl, and -CO 2 (C 1~4 Selected from alkyl groups; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R 14 and R C2 Each is independent, either non-existent or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONRc R d They may also be substituted with more preferred substituents; R 16 and R C1 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl; and R 15 、R 17 、R 18 , or R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z 1 、Z 2 、Y 1 , and Y 2 Each of these is N, and W 1 、W 2 、X 1 , and X 2 (b) W 1 、W 2 、X 1 , and X 2 Each of these is N, and Z 1 、Z 2 、Y 1 , and Y 2 (c) Z 1 and Y 1 Each of these is N, and W 1 and X 1 (d) Z 2 and Y 2 Each of these is N, and W 2 and X 2 (e) W 1 and X 1 Each of these is N, and Z 1 and Y 1 (f) W 2 and X 2 Each of these is N, and Z 2 and Y 2 If each of them is C, then X 3 and X 4 At least one of them is S; or X 9 is N; or, (ii) (a) Z 1 、Z 2 、Y 1 , and Y 2 Each of these is N, and W 1 、W 2 、X 1 , and X 2 (b) W 1 、W 2 、X 1 , and X 2 Each of these is N, and Z 1 、Z 2 、Y 1 , and Y 2 If each of them is C, then R 14 is halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) (a) Z 1 and Y 1 Each of these is N, and W 1 and X 1 (b) Z 2 and Y 2 Each of these is N, and W 2 and X 2 (c) W 1 and X 1 Each of these is N, and Z 1 and Y 1 (d) W 2 and X 2 Each of these is N, and Z2 and Y 2 If each of them is C, then X 5 、X 6 , and X 9 At least one of them is N, and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl) or substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, C 1~4 Alkoxyl, -N(R e )(R f ), -CO 2 (R f ), -CON(R e )(R f ), and may be substituted with 1 to 4 substituents independently selected from the group including -COOH. [Invention 1007] Any compound of the present invention, which is a compound of formula (V), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000010.tif69128 。 [Invention 1008] W 1 、X 1 、Y 1 , and Z 1 A compound according to the present invention, wherein each of the elements is independently O, S, C, or N. [Invention 1009] W 1 A compound of the present invention, wherein is O or C. [Invention 1010] X 1 A compound of the present invention, wherein the element is C or N. [Invention 1011] Y 1 A compound of the present invention, wherein the element is C or N. [Invention 1012] Z 1 A compound of the present invention, wherein is O or C. [Invention 1013] W 2 、X 2 、Y 2 , and Z 2 A compound according to the present invention, wherein each of the elements is independently O, S, C, or N. [Invention 1014] W 2 A compound of the present invention, wherein is O or C. [Invention 1015] X 2 A compound of the present invention, wherein the element is C or N. [Invention 1016] Y 2 A compound of the present invention, wherein the element is C or N. [Invention 1017] Z 2 A compound of the present invention, wherein is O or C. [Invention 1018] X 3 and X 4 Each of them independently determines whether it is S or NR f A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1019] X 3 Any of the compounds of the present invention, wherein is S. [Invention 1020] X 3 NR f A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1021] X 4 Any of the compounds of the present invention, wherein is S. [Invention 1022] X 4 NR f A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1023] Any of the compounds of the present invention described above, wherein r is 1. [Invention 1024] Any of the compounds of the present invention, wherein s is 0. [Invention 1025] Any of the compounds of the present invention described above, wherein p is 1. [Invention 1026] R A1 and R A2 Each of these independently comprises H, halogen, hydroxyl, and -N(R) e )(R f ), -CO 2 R f , -N(R f )COR b , -N(R g )SO 2 (C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO 2 (R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-, Halo-(C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- Any of the compounds of the present invention described above. [Invention 1027] R A1 and R A2 Each of these independently represents H, halogen, and (C 1~6 Alkyl)oxy-, hydroxy(C 2~6 Alkyl)oxy-, HO(O)C-(C 2~6 Alkyl)oxy-, amino(C 2~6 Alkyl)oxy-, hydroxy, amino, or amino(C 1~4 A compound of the present invention that is alkyl-. [Invention 1028] R A1 and R A2 These independently form H, halogen, hydroxyl, and -OCH 2 CH 2 CH 2 OH, -OCH 2 CH 2 CH 2 COOH, -OCH 2 CH 2 CH 2 NH 2 ,-OCH 3 , or -N(R e )(R f A compound of the present invention that is any of the above-mentioned compounds. [Invention 1029] R A2 (C 1~6 It is alkyl)oxy-, where the substituted (C 1~6 Alkyl)oxy-(C 1~6 Any of the compounds of the present invention described above, wherein the alkyl group is substituted with a hydroxyl group. [Invention 1030] R A2 ga-OCH 2 CH 2 CH2 Any of the compounds of the present invention that are OH. [Invention 1031] s is 0, W 1 and Z 2 Each of them is independently C or N, and R C1 and R C2 Each of these is independent of the others, either nonexistent, H, or C. 1~4 A compound of the present invention that is alkyl. [Invention 1032] r is 1, R B1 and R B2 Each of them independently becomes -CH 2 - and B is R B1 and R B2 Together with it, it forms a linking group, where B is a bond, or B is a -halo(C 1~10 Alkyl)-, may be substituted-C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, optionally substituted C 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)C 1~4 Alkyl-, Here, the substitution may be made -C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl-C) 1~4 The alkyl part of alkyl)- is a halogen, halo(C 1~4 alkyl), -OH, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -OR c , -NH 2 , -NR c R d , -OCOR c , -CO 2 H, -CO 2 R c -SOR c , -SO 2 R c ,-CONH 2 ,-CONR c R d , -SO 2 NH 2 , -SO 2 NR c R d ,-OCONH 2 ,-OCONR c R d , -NR d COR c , -NR d SOR c , -NR d , and -NR d SO 2 R c The C may be substituted with one or two substituents that are selected more independently of each other. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)C 1~4 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety contains halogens, hydroxyls, and -OP(O)(OH) 2 ,-OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, -C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, -C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and -C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- Any of the compounds of the present invention described above. [Invention 1033] r is 1, R B1 and R B2 Each of them independently becomes -CH 2 - and B is replaced by -C 1~10 Alkyl group or unsubstituted C 1~10 Alkyl-, -C 2~10 Alkenyl-, -C 2~10 Alkinyl-, -C 1~6 Alkyl-OC 1~6 Alkyl-, or -C 1~6 Alkyl-NR a -C 1~6 It is an alkyl group, where the substituted -C 1~10 Alkyl groups are halogens, hydroxyls, and -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , amino, (C 1~4 Alkyl)amino, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Any of the compounds of the present invention described above, which are substituted with 1 to 4 substituents independently selected from alkoxy-. [Invention 1034] r is 1, R B1 and R B2 Each of them independently becomes -CH 2 - and B is -CH=CH-, -CH 2 CH 2 -, -CH(OH)CH(OH)-, or -CH 2 N(CH 3 )CH 2 -A compound of the present invention as described above. [Invention 1035] r is 1 and B is R B1 and R B2 Together with -CH 2 CH= CH CH 2 -A compound of the present invention that forms - [Invention 1036] R 3 and R 5 Each of them independently performs -CON(R d )(R f ), -CH 2 N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH 2 N(R d )CO(R f A compound of the present invention that is any of the above-mentioned compounds. [Invention 1037] R 3 and R 5 Each of them independently performs -CON(R d )(R f A compound of the present invention that is any of the above-mentioned compounds. [Invention 1038] R 3 and R 5 Each of these is -CONH 2 A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1039] R 4 and R 6 Any of the compounds of the present invention, wherein each of them is H. [Invention 1040] R 4 and R 6 Each of these independently controls halogen and halo (C 1~4 Alkyl), Halo (C 1~6 Alkoxy)-,hydroxy,-OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -NH 2 , -NR C R C , -NR c R d , -COR c , -CO 2 R c , -N(R d )COR c , -N(R d )SO 2 R c , -N(R g )SO 2 (C1~2 Alkyl)-N(R h )(R, -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 2~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted-C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH) 2 ,-OP(O)(R I R II ) 2 , -OR c , -NH 2 , -NR C R C , -NR c R d , -CO 2 H, -CO 2 R c OCOR c , -CO 2 R c -SOR c , -SO 2 R c ,-CONH 2 ,-CONR c R d , -SO 2 NH 2 , -SO 2 NR cR d ,-OCONH 2 ,-OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO 2 R c , -NR d SO 2 R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH) 2 、-(C 1~4 Alkyl)-OP(O)(R I R II ) 2 Hello (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH) 2 、-(C 2~4 Alkoxy)-OP(O)(R I R II ) 2 、C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO 2 R d They may be substituted with 1 to 4 substituents that are selected more independently of each other. Any of the compounds of the present invention described above. [Invention 1041] R 14 Any of the compounds of the present invention that do not contain the aforementioned compound. [Invention 1042] R 14 C may be halogenated or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d Any of the compounds of the present invention described above, which may be substituted with a more selected substituent. [Invention 1043] R 16 Any of the compounds of the present invention, wherein H is either present or absent. [Invention 1044] R 16 C 1~4 A compound of the present invention that is alkyl. [Invention 1045] R 16 Any of the compounds of the present invention, wherein the compound is ethyl. [Invention 1046] R 15 and R 17 Any of the compounds of the present invention described above, in which each of these is independently absent. [Invention 1047] R 15 and R 17 Each of these can independently be H, cyclopropyl, halogen, or optionally substituted C1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 However, any of the compounds of the present invention, wherein they combine with one or more atoms connecting them to form a 5-6 membered ring. [Invention 1048] R 15 and R 19 However, any of the compounds of the present invention, wherein they combine with one or more atoms connecting them to form a 5-6 membered ring. [Invention 1049] R 16 and R 17 However, any of the compounds of the present invention, wherein they combine with one or more atoms connecting them to form a 5-6 membered ring. [Invention 1050] R 18 and R 19 Any of the compounds of the present invention described above, in which each of these is independently absent. [Invention 1051] R 18 and R 19 Each of these can be independently H, a halogen, or a substituted C. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c Rd , -SO 2 NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 17 and R 18 However, any of the compounds of the present invention, wherein they combine with one or more atoms connecting them to form a 5-6 membered ring. [Invention 1052] R 18 and R 19 Each of these C elements may be independently halogenated or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , -CH 2 -CO 2 R c , and -OCONR c R d Any of the compounds of the present invention described above, which may be substituted with a more selected substituent. [Invention 1053] R 17 and R 18 However, any of the compounds of the present invention, wherein they combine with one or more atoms connecting them to form a 5-6 membered ring. [Invention 1054] R 14 、R 15 、R 16 、R 17 、R 18 , and R 19 Each of these is independent of the others, either nonexistent, H, or C. 1~4 A compound of the present invention that is alkyl. [Invention 1055] X 5 Any of the compounds of the present invention, wherein is N. [Invention 1056] X 5 CR A2 And here R A2 H, halogen, -OCH 2 CH 2 CH 2 OH, -OCH 2 CH 2 CH 2 COOH, -OCH 2 CH 2 CH 2 NH 2 ,-OCH 3 , and -N(R e )(R f A compound selected from any of the above-mentioned compounds of the present invention. [Invention 1057] X 5 CR A2 And here R A2 ga-OCH 2 CH 2 CH 2 OH, -OCH 2 CH 2 CH 2 Any of the compounds of the present invention selected from COOH. [Invention 1058] X 6 Any of the compounds of the present invention, wherein is N. [Invention 1059] X 6 CR A1 A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1060] X 5 N is X 6 CR A1 A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1061] X 6 N is X 5 CR A1 A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1062] X 6 N is X 5 CR A1 And here R A1 ga-OCH 2 CH 2 CH 2 Any of the compounds of the present invention that are OH. [Invention 1063] X 3 and X 4 Each of them independently determines whether it is S or NR f And here R f Any of the compounds of the present invention, wherein is H. [Invention 1064] X 3 S is X 4 NR f And here R f Any of the compounds of the present invention, wherein is H. [Invention 1065] X 9 Any of the compounds of the present invention, wherein is N. [Invention 1066] X 9 CR 4 A compound of the present invention, which is any of the above-mentioned compounds. [Invention 1067] X 9 A compound of the present invention, wherein is CH. [Invention 1068] The compound is a compound of formula (V'), and the compound is any of the compounds of the present invention, wherein the compound is a compound of formula (Va), formula (Vb), formula (Vc), formula (Vd), formula (Ve), formula (V-e1), or formula (V-e2), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000011.tif63139TIFF0007843695000012.tif184142 During the ceremony, X 5 is N or CR A2 and; X 6 is N or CR A1 and; R A2 and R A1 If present, each may be independently halogenated, hydroxylated, or substituted (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl) or substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxyl, C 1~4 Alkoxyl, -N(R e )(R f ), -CO 2 (R f ), -CON(R e )(R f ), and may be substituted with 1 to 4 substituents independently selected from the group including -COOH; and X 3 、X 4 、R C1 、R C2 、R 3 、R 5 、R e 、R f 、R 14 、R 15 、R 16 、R 17 、R 18 , and R 19 These are each independent, as defined in equation (V'). [Invention 1069] Compounds of the present invention 1068, which are formula (Vb), formula (Vc), formula (Vd), formula (Ve), formula (V-e1), or formula (V-e2), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers. [Invention 1070] The compound is a compound of formula (V'), and the compound is any of the compounds of the present invention, wherein the compound is a compound of formula (Vf), formula (V-f1), formula (V-f2), formula (V-f3), formula (V-f4), formula (V-f5), formula (V-f6), or formula (V-f7), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000013.tif58142TIFF0007843695000014.tif185148 During the ceremony, Y 2 and Z 2 Each of these is independently O, S, C, or N; X 2 and W 2 Each is independently either C or N; X 3 、X 4 、X 5 、X 6 、X 9 、R 16 、R C1 、R c 、R 3 、R 5 、R 17 、R 18 、R 19 , and R d Each is independent, as defined in equation (V'); and R C2 Each is independent, either non-existent or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d They may be substituted with more selective substituents. [Invention 1071] A compound of the present invention 1070, which is a compound of formula (V-f1), formula (V-f2), formula (V-f3), formula (V-f4), formula (V-f5), formula (V-f6), or formula (V-f7), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof. [Invention 1072] The compound is a compound of formula (V'), and the compound is any of the compounds of the present invention, wherein the compound is of formula (Vg), formula (V-g1), formula (V-g2), formula (V-g3), formula (V-g4), formula (V-g5), formula (V-g6), or formula (V-g7), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000015.tif116143TIFF0007843695000016.tif125149 During the ceremony, Y 2 and Z 2 Each of these is independently O, S, C, or N; X 2 and W 2 Each is independently either C or N; X 3 、X 4 、X 5 、X 6 、X 9 、R c 、R C1 、R 3 、R 5 、R 16 、R 17 、R 18 、R 19 , and R d Each is independent, as defined in equation (V'); and R C2 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d They may be substituted with more selective substituents. [Invention 1073] A compound of the present invention 1072, which is formula (V-g1), formula (V-g2), formula (V-g3), formula (V-g4), formula (V-g5), formula (V-g6), or formula (V-g7), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof. [Invention 1074] The compound is a compound of formula (V'), and the compound is any of the compounds of the present invention, wherein the compound is a compound of formula (Vh), formula (V-h1), formula (V-h2), formula (V-h3), formula (V-h4), formula (V-h5), formula (V-h6), or formula (V-h7), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000017.tif196143TIFF0007843695000018.tif64143 During the ceremony, Y 1 and Z 1 Each of these is independently O, S, C, or N; X 1 and W 1 Each is independently either C or N; X 5 、X 6 、X 9 、X 3 、X 4 、R c 、R 3 、R 5 、R 16 、R 15 、R 18 、R 19 、R C1 , and R d Each is independent, as defined in equation (V'); and R 14 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO 2 R c ,-CONR c R d , -SO 2 NR c R d , and -OCONR c R d They may be substituted with more selective substituents. [Invention 1075] A compound of the present invention 1074, which is formula (V-h1), formula (V-h2), formula (V-h3), formula (V-h4), formula (V-h5), formula (V-h6), or formula (V-h7), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof. [Invention 1076] The compound is a compound of formula (V'), and the compound is any of the compounds of the present invention, wherein the compound is a compound of formula (Vi), formula (V-i1), formula (V-i2), formula (V-i3), formula (V-i4), formula (V-i5), formula (V-i6), or formula (V-i7), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000019.tif183144TIFF0007843695000020.tif58141 During the ceremony, X 5 、X 6 、X 9 、X 3 、X 4 、R 3 、R 5 、R 16 、R 18 、R 19 , and R C1 These are each independent, as defined in equation (V'). [Invention 1077] Compounds of the present invention 1076, which are formulas (V-i1), (V-i2), (V-i3), (V-i4), (V-i5), (V-i6), or (V-i7), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers. [Invention 1078] Any of the compounds of the present invention that are not selected from the following: TIFF0007843695000021.tif42154TIFF0007843695000022.tif188158TIFF0007843695000023.tif142155TIFF0007843695000024.tif196158 。 [Invention 1079] Any of the compounds of the present invention, except for the following: (E)-N,N'-(buta-2-ene-1,4-diylbis(5-carbamoyl-7-(2-hydroxyethoxy)-1H-benzo[d]imidazole-1,2-diyl))bis(4-ethyl-2-methyloxazole-5-carboxamide); (E)-N,N'-(buta-2-ene-1,4-diylbis(5-carbamoyl-7-hydroxy-1H-benzo[d]imidazole-1,2-diyl))bis(4-ethyl-2-methyloxazole-5-carboxamide); (E)-N-(5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-7-hydroxy-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methoxy-1H-benzo[d]imidazole-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide; N,N'-((((1S,2S)-cyclopropane-1,2-diyl)bis(methylene))bis(5-carbamoyl-1H-benzo[d]imidazole-1,2-diyl))bis(4-ethyl-2-methyloxazole-5-carboxamide); (E)-1,1'-(buta-2-en-1,4-diyl)bis(2-(2,5-dimethylfuran-3-carboxamide)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide); (E)-N,N'-(Hexa-3-ene-1,6-diylbis(5-carbamoyl-1H-benzo[d]imidazole-1,2-diyl))bis(4-ethyl-2-methyloxazole-5-carboxamide); (E)-N-(5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methyl-1H-benzo[d]imidazole-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide; (E)-N-(5-carbamoyl-1-(4-(5-carbamoyl-2-(2,4-dimethyloxazole-5-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methyl-1H-benzo[d]imidazole-2-yl)-2,4-dimethyloxazole-5-carboxamide; (E)-N,N'-(buta-2-ene-1,4-diylbis(5-carbamoyl-7-methoxy-1H-benzo[d]imidazole-1,2-diyl))bis(2,4-dimethyloxazole-5-carboxamide); (E)-N,N'-(buta-2-ene-1,4-diylbis(5-carbamoyl-7-methoxy-1H-benzo[d]imidazole-1,2-diyl))bis(4-ethyl-2-methyloxazole-5-carboxamide); (E)-1,1'-(buta-2-en-1,4-diyl)bis(2-(1-ethyl-1H-imidazole-5-carboxamide)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide); (E)-1,1'-(buta-2-en-1,4-diyl)bis(2-(1-ethyl-1H-imidazole-2-carboxamide)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide); (Z)-4-carbamoyl-1,15-bis(4-ethyl-2-methyloxazole-5-carboxamide)-8,9,16,19-tetrahydro-7H-6,10-dioxa-2,14,15a,19a-tetraazacyclopentadeca[3,2,1-cd:8,9,10-c'd']diindene-12-carboxylic acid; (E)-1-(4-(5-carbamoyl-2-(furan-2-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-2-(furan-2-carboxamide)-7-methyl-1H-benzo[d]imidazole-5-carboxamide; (E)-1-(4-(5-carbamoyl-2-(pyrazolo[1,5-a]pyridine-2-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methyl-2-(pyrazolo[1,5-a]pyridine-2-carboxamide)-1H-benzo[d]imidazole-5-carboxamide; (E)-1-(4-(5-carbamoyl-2-(1-methyl-1H-pyrrole-2-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methyl-2-(1-methyl-1H-pyrrole-2-carboxamide)-1H-benzo[d]imidazole-5-carboxamide; (E)-1-(4-(5-carbamoyl-2-(1H-pyrrole-2-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methyl-2-(1H-pyrrole-2-carboxamide)-1H-benzo[d]imidazole-5-carboxamide; (E)-1-(4-(5-carbamoyl-2-(1-methyl-1H-indole-2-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methyl-2-(1-methyl-1H-indole-2-carboxamide)-1H-benzo[d]imidazole-5-carboxamide; (E)-N-(5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-7-(3-hydroxypropoxy)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methoxy-1H-benzo[d]imidazole-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide; (Z)-1,15-bis(4-ethyl-2-methyloxazole-5-carboxamide)-8,9,16,19-tetrahydro-7H-6,10-dioxa-2,14,15a,19a-tetraazacyclopentadeca[3,2,1-cd:8,9,10-c'd']diindene-4,12-dicarboxamide; N-(5-carbamoyl-1-(2-((1R,2R)-2-(2-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-1H-benzo[d]imidazole-1-yl)ethyl)cyclopropyl)ethyl)-7-methyl-1H-benzo[d]imidazole-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide; (E)-N-(5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-7-(2-hydroxyethoxy)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-methoxy-1H-benzo[d]imidazole-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide; (E)-2-((5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-7-methoxy-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-2-(4-ethyl-2-methyloxazole-5-carboxamide)-1H-benzo[d]imidazole-7-yl)oxy)acetic acid; (E)-2-((5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-7-(2-hydroxyethoxy)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-2-(4-ethyl-2-methyloxazole-5-carboxamide)-1H-benzo[d]imidazole-7-yl)oxy)acetic acid; (E)-1,15-bis(4-ethyl-2-methyloxazole-5-carboxamide)-N-(2-hydroxyethyl)-8,9,16,19-tetrahydro-7H-6,10-dioxa-2,14,15a,19a-tetraazacyclopentadeca[3,2,1-cd:8,9,10-c'd']diindene-4,12-dicarboxamide; (E)-N-(5-carbamoyl-1-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazole-5-carboxamide)-7-methoxy-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-7-(2-(dimethylamino)ethoxy)-1H-benzo[d]imidazole-2-yl)-4-ethyl-2-methyloxazole-5-carboxamide; or (E)-1-(4-(5-carbamoyl-2-(1-(2-hydroxyethyl)-3-methyl-1H-pyrazole-5-carboxamide)-1H-benzo[d]imidazole-1-yl)buta-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamide)-1H-benzo[d]imidazole-5-carboxamide. [Invention 1080] Any of the compounds of the present invention, wherein ring 1 is selected from any one of the following: TIFF0007843695000025.tif158161 During the ceremony, R 14 、R 15 、R 19 , and R C1 H and C are independent of each other. 1~4 Alkyl, halogen, or optionally substituted C 1~4 It is alkyl, and here the C 1~4 Alkyl can be substituted. 1~4 Alkyls are halogens or -CO 2 This is a substituent with H. [Invention 1081] Any of the compounds of the present invention, wherein ring 1 and ring 2 are each independently selected from one of the following: TIFF0007843695000026.tif148161TIFF0007843695000027.tif174161 。 [Invention 1082] A compound of the present invention, selected from the compounds listed in Table 1, their tautomers, their prodrugs, and their salts. [Invention 1083] A pharmaceutical composition comprising any of the compounds of the present invention described above and a pharmaceutically acceptable excipient. [Invention 1084] A method for treating or preventing a STING-mediated disease or disorder in a subject in need, comprising the step of administering a pharmaceutically effective amount of any of the compounds of the present invention or its antibody-STING agonist conjugate to the subject. [Invention 1085] Any of the compounds of the present invention, or their antibody-STING agonist conjugates, for use in the treatment or prevention of STING-mediated diseases or disorders in subjects where such treatment is necessary. [Invention 1086] Use of any of the compounds of the present invention, or their antibody-STING agonist conjugates, in the manufacture of pharmaceuticals for the treatment or prevention of STING-mediated diseases or disorders in subjects where such treatment is necessary. [Invention 1087] Any method, compound, conjugate, or use of the present invention wherein the STING-mediated disease or disorder is cancer. Other features and advantages of this disclosure will be apparent from the following detailed description and claims. [Modes for carrying out the invention]

[0010] Detailed explanation References herein to compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), and their salts, should be understood to encompass compounds of formulas (I'), (IA'), (II'), (III'), (IV'), or (V') as free bases or as salts thereof, for example, as pharmaceutically acceptable salts thereof. Accordingly, in some embodiments, this disclosure relates to compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V') as free bases. In some embodiments, this disclosure relates to compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), and their salts. In some embodiments, the disclosure relates to compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), and pharmaceutically acceptable salts thereof.

[0011] Compounds comprising one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or pharmaceutically acceptable salts thereof, are STING modulators. Accordingly, this disclosure provides compounds comprising one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or pharmaceutically acceptable salts thereof, for therapeutic use. This disclosure provides the use of compounds comprising one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or pharmaceutically acceptable salts thereof, as effective therapeutic agents in the treatment of STING-mediated diseases or disorders. In some embodiments, the present invention provides compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or pharmaceutically acceptable salts thereof, for use in the treatment of diseases mediated by STING stimulant or STING antagonistic effects. The present disclosure also provides compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or pharmaceutically acceptable salts thereof, for use in the manufacture of pharmaceuticals for the treatment of STING-mediated diseases or disorders.

[0012] The Disclosure further relates to a method for modulating STING, comprising the step of contacting cells with a compound having one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or a salt thereof containing a pharmaceutically acceptable salt. The Disclosure further relates to a method for treating a STING-mediated disease or disorder, comprising the step of administering to a patient (human or other mammal) in need of such treatment a therapeutically effective amount of a compound having one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or a salt thereof containing a pharmaceutically acceptable salt. Such STING-mediated diseases or disorders include inflammation, allergic and autoimmune diseases, infectious diseases, cancer, and precancerous syndromes. Furthermore, STING modulators may be useful as immunogenic compositions or vaccine adjuvants.

[0013] This disclosure further relates to a pharmaceutical composition comprising a compound having one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. This disclosure relates to a pharmaceutical composition for the treatment of STING-mediated diseases or disorders comprising a compound having one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

[0014] definition The chemical names given to intermediate compounds and / or compounds of the disclosure described herein may refer to any one of the tautomeristic representations of the compound (in some cases such alternative names are demonstrated by experimental studies). It should be understood that any nominalized compound (intermediate compound or compound of the disclosure) or structurally illustrated compound (intermediate compound or compound of the disclosure) is intended to encompass all tautomeristic forms of the compound, including the zwitterionic form, and any mixture thereof.

[0015] In any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V'), If TIFF0007843695000028.tif6128 exists, it indicates Ring 1 which may be defined according to various embodiments described herein, and, If TIFF0007843695000029.tif6128 exists, it will be understood to indicate Ring 2, which may be defined according to the various embodiments described herein.

[0016] It should be understood that embodiments of compounds of formula (I'), (IA'), (II'), (III'), (IV'), or (V') are intended to encompass formulas (I'), (IA'), (II'), (III'), (IV'), and (V') where appropriate.

[0017] It should be understood that the terms “in some aspects,” “in some aspects of the present disclosure,” and “in some aspects of the compounds of the present disclosure” are interchangeable, where appropriate.

[0018] As used herein, the term "alkyl" refers to a saturated linear or branched hydrocarbon group having a specified number of carbon atoms. 1~4 The term "alkyl" refers to a linear or branched alkyl moiety containing 1 to 4 carbon atoms. Exemplary alkyls include, but are not limited to, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, t-butyl, pentyl, and hexyl.

[0019] Terms such as "alkyl" and substituents are used, for example, "hydroxy(C) 1~4 When used in combination with the term of another substituent, as in "(alkyl)", the term of the linking substituent (e.g., alkyl) is intended to encompass the divalent portion through which the bond point passes. 1~4Examples of alkyl groups include, but are not limited to, hydroxymethyl, hydroxyethyl, and hydroxyisopropyl.

[0020] As used herein, the term "halo(alkyl)" refers to a saturated linear or branched hydrocarbon group having a specified number (n) of carbon atoms and one or more (up to 2n+1) halogen atoms. For example, "halo(C 1~4 The term "alkyl)" refers to a group having one or more halogen atoms, which may be the same or different, at one or more carbon atoms of the alkyl moiety containing 1 to 4 carbon atoms. 1~4 Examples of alkyl groups include, but are not limited to, -CF3 (trifluoromethyl), -CCl3 (trichloromethyl), 1,1-difluoroethyl, 2,2,2-trifluoroethyl, and hexafluoroisopropyl.

[0021] As used herein, the term "alkenyl" means a straight-chain or branched hydrocarbon group having a specified number of carbon atoms and at least one and up to three carbon-carbon double bonds. Examples include ethenyl and propenyl.

[0022] As used herein, the term "alkynyl" means a linear or branched hydrocarbon group having a specified number of carbon atoms and at least one and up to three carbon-carbon triple bonds. Examples include ethynyl and propynyl.

[0023] As used herein, the terms “alkoxy-” or “(alkyl)oxy-” mean an alkyl-oxy- group that contains an alkyl moiety having a specified number of carbon atoms bonded through an oxygen-linked atom. For example, “C 1~4 The term "alkoxy-" refers to a saturated linear or branched hydrocarbon moiety having at least one and up to four carbon atoms linked through oxygen-bonding atoms. An example is "C 1~4 Alkoxy-" or "(C 1~4Examples of alkyl)oxy groups include, but are not limited to, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, s-butoxy, and t-butoxy.

[0024] As used herein, the term "halo(alkoxy)-" refers to a saturated linear or branched hydrocarbon group having a specified number (n) of carbon atoms and one or more (up to 2n+1) halogen atoms bonded through an oxygen-linked atom. For example, "halo(C 1~4 The term "alkoxy)-" refers to a bonded atom connected through an oxygen-linked atom, "halo(C) 1~4 This refers to a "haloalkyl-oxy-" group that includes the "alkyl)" portion. An example is "halo(C) 1~4 Examples of alkoxy-- groups include, but are not limited to, -OCHF2 (difluoromethoxy), -OCF3 (trifluoromethoxy), -OCH2CF3 (trifluoroethoxy), and -OCH(CF3)2 (hexafluoroisopropoxy).

[0025] As used herein, the term "amino" means a substituent containing at least one nitrogen atom. Specifically, -NH2, -NH(C) 1~4 Alkyl), alkylamino, or (C 1~4 Alkyl)amino- or (C 1~4 Alkyl)(C 1~4 The term "amino" includes alkyl)amino- or dialkylamino, amide-, carbamide-, urea, and sulfamide substituents.

[0026] As used herein, the term “carbocyclic group or carbocyclic moiety” means a cyclic group or cyclic moiety whose ring members are carbon atoms, which may be saturated, partially unsaturated (non-aromatic), or fully unsaturated (aromatic).

[0027] As used herein, the term "cycloalkyl" means a non-aromatic saturated hydrocarbon ring group containing a specified number of carbon atoms in the ring. For example, "C 3~6The term "cycloalkyl" refers to a cyclic group having 3 to 6 ring carbon atoms. An example is "C 3~6 Examples of "cycloalkyl" groups include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.

[0028] As used herein, the term “heterocyclic group or heterocyclic moiety” means a cyclic group or cyclic moiety having at least two different elemental atoms as ring members, which may be saturated, partially unsaturated (non-aromatic), or fully unsaturated (aromatic).

[0029] As used herein, the term “heteroatom” means a nitrogen atom, a sulfur atom, or an oxygen atom, for example, a nitrogen atom or an oxygen atom.

[0030] As used herein, the term "heterocycloalkyl" means a non-aromatic monocyclic or bicyclic group comprising 3 to 10 ring atoms and one or more (generally one or two) heteroatom ring members independently selected from oxygen, sulfur, and nitrogen. The bonding site of the heterocycloalkyl group can be any suitable carbon or nitrogen atom.

[0031] Examples of heterocycloalkyl groups include, but are not limited to, azilidinyl, thyranil, oxyranil, azetidinil, oxetanil, thietanil, pyrrolidinyl, tetrahydrofuranil, tetrahydrothienyl, 1,3-dioxolanil, piperidinil, piperazinil, tetrahydropyranil, dihydropyranil, tetrahydrothiopyranil, 1,3-dioxanil, 1,4-dioxanil, 1,3-oxathiolanil, 1,3-oxathianil, 1,3-dithianil, 1,4-oxathiolanil, 1,4-oxathianil, 1,4-dithianil, morpholinil, thiomorpholinil, and hexahydro-1,4-diazepinyl.

[0032] Examples of "four-membered heterocycloalkyl" groups include oxetanyl, thietanyl, and azetidinyl.

[0033] As used herein, the term “5-6 membered heterocycloalkyl” means a saturated monocyclic group containing five or six ring atoms, each containing one or two heteroatoms independently selected from oxygen, sulfur, and nitrogen. Examples of 5-6 membered heterocycloalkyl groups include, but are not limited to, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperidinyl, piperazinyl, morpholinyl, and thiomorpholinyl.

[0034] As used herein, the term "heteroaryl" means an aromatic monocyclic or bicyclic group comprising 5 to 10 ring atoms including 1 to 4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and in which at least a portion of the group is aromatic. For example, the term includes bicyclic heterocyclic aryl groups comprising a phenyl ring fused to a heterocyclic portion, or a heteroaryl ring portion fused to a carbocyclic portion. The bonding sites of the heteroaryl group can be any preferred carbon or nitrogen atoms.

[0035] As used herein, the term “5- to 6-membered heteroaryl” means an aromatic monocyclic group containing five or six ring atoms, each containing at least one carbon atom and one to four heteroatoms independently selected from nitrogen, oxygen, and sulfur. A selected 5-membered heteroaryl group contains one nitrogen, oxygen, or sulfur ring heteroatom and may contain one, two, or three additional nitrogen ring atoms. A selected 6-membered heteroaryl group contains one, two, or three nitrogen ring heteroatoms. Examples of 5-membered heteroaryl groups include furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl, isoxazolyl, and oxadiazolyl. Examples of selected 6-membered heteroaryl groups include pyridinyl, pyrazinyl, pyrimidinyl, pyridadinyl, and triazinyl.

[0036] As used herein, the term “9- to 10-membered heteroaryl” means an aromatic bicyclic group containing nine or ten ring atoms, each containing one to four heteroatoms independently selected from nitrogen, oxygen, and sulfur. Examples of 9-membered heteroaryl (6,5-condensed heteroaryl) groups include benzothienyl, benzofuranyl, indolyl, indolinyl (dihydroindolyl), isoindolyl, isoindolinyl, indazolyl, isobenzofuryl, 2,3-dihydrobenzofuryl, benzoxazolyl, benzoisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzimidazolyl, benzoxadiazolyl, benzothiadiazolyl, benzotriazolyl, prinyl, imidazopyridinyl, pyrazolopyridinyl, triazolopyridinyl, and 1,3-benzodioxolyl.

[0037] Examples of 10-membered heteroaryl (6,6-condensed heteroaryl) groups include, but are not limited to, quinolinyl (quinolyl), isoquinolyl, phthalazinyl, naphthilidinyl (1,5-naphthilidinyl, 1,6-naphthilidinyl, 1,7-naphthilidinyl, 1,8-naphthilidinyl), quinazolinyl, quinoxalinyl, 4H-quinolidinyl, 1,2,3,4-tetrahydroquinolinyl (tetrahydroquinolinyl), 1,2,3,4-tetrahydroisoquinolinyl (tetrahydroisoquinolinyl), synnolinyl, pteridinyl, and 2,3-dihydrobenzo[b][l,4]dioxynyl.

[0038] As used herein, the terms "halogen" and "halo" refer to halogen groups, such as fluoro, chloro, bromo, or iodo substituents.

[0039] As used herein, the term "oxo" refers to the double bond oxygen moiety, which, for example, forms a carbonyl moiety (C = 0) when directly bonded to a carbon atom.

[0040] As used herein, the terms "hydroxy" or "hydroxyl" are intended to mean the -OH group.

[0041] As used herein, the term "cyano" refers to a nitrile group -C≡N.

[0042] As used herein, the term "may be substituted" means that a group (e.g., alkyl group, cycloalkyl group, alkoxy group, heterocycloalkyl group, aryl group, or heteroaryl group) or a ring or part may not be substituted, or that the group, ring, or part may be substituted according to the definitions of substituents as set forth herein (A, R 3 This indicates that the group may be substituted with one or more substituents as defined in (etc.). If a group can be selected from several alternative groups, the selected groups may be the same or different.

[0043] As used herein, the term “independently” means that when two or more substituents are selected from several possible substituents, the substituents may be the same or different.

[0044] As used herein, the term “pharmaceutically acceptable” means a compound, raw material, composition, and dosage form that, within the bounds of sound medical judgment, is suitable for use in contact with human and animal tissues, without excessive toxicity, irritation, or other problems or complications, and that corresponds to a reasonable benefit-to-risk ratio.

[0045] The length of a linking group as defined herein is -R B1 -BR B2 -and / or -R C1 -DR C2 - Represents the minimum number of atoms in a direct chain composed of -. For example, if B is a phenyl which may be substituted, then the linking group -R B1 -BR B2 - can be represented as -(CH2)-phenyl-(CH2)-. When two -(CH2)- moieties are located on adjacent carbon atoms of the phenyl ring (1,2-substituted phenyl), this linking group is characterized as a four-membered linking group.

[0046] In some embodiments, when two -(CH2)- moieties are substituted at the para position of the phenyl ring (1,4-substituted phenyl), this linking group is characterized as a six-membered linking group. It will be understood that any alkyl, alkenyl, or alkynyl group or moiety of B or D can be linear or branched alkyl, alkenyl, or alkynyl group or moiety. For example, if B is -C 1~10 Alkyl--R B1 -BR B2 - The linking group is (C 1~4 Alkyl) branched group or 2-4 (C) 1~3 The alkyl group may include an 8-membered linkage having, for example, four branched methyl groups (two gem-dimethyl groups) or two branched methyl groups.

[0047] As used herein, the terms “compounds of the disclosure” or “compounds of this disclosure” mean compounds of formulas (I'), (IA'), (II'), (III'), (IV'), and (V') as defined herein, in any form, namely any tautomerized form, any isomerized form, any salt or non-salt form (e.g., as a free acid or free base, or a salt thereof, in particular as a pharmaceutically acceptable salt), and any physical form thereof (e.g., non-solid form (e.g., liquid or semi-solid form) and solid form (e.g., amorphous or crystalline form, certain polymorphic forms, solvate forms including hydrate forms (e.g., monohydrate, dihydrate, and hemihydrate)), and in the form of various forms of mixtures.

[0048] Accordingly, compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V') as defined herein, in any salt or unsalted form, any physical form thereof, and in various forms of mixtures, are included in this disclosure. Although these are included in this disclosure, it will be understood that compounds of any one or more of the formulas (I'), (IA'), (II'), (III'), (IV'), or (V') as defined herein, in any salt or unsalted form, and any physical form thereof, may exhibit different levels of activity, different bioavailability, and different handling characteristics depending on the purpose of formulation.

[0049] Compounds of the Disclosure In some respects, this disclosure provides compounds of formula (IA'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers: TIFF0007843695000030.tif73128In formula, W1, X1, Y1, Z1, W2, X2, Y2, and Z2 are each independently O, S, C, or N; X3 and X4 are independently S or NR f and; X5 is N or CR A2 and; X6 is N or CR A1 and; X9 is N or CR 4 and; r and s are independently either 0 or 1; p is either 1 or 2; The sum of r and s is 1 or 2; R A1 and R A2 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2Rf , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If r is 0, B1 and R B2 Each of these is independently H, and C may be substituted. 1~6 Alkyl, Halo(C) 1~6 C (alkyl), may be substituted. 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 The cycloalkyl group is a substituted or substituted 4-6 member heterocycloalkyl group, a substituted or substituted phenyl group, a substituted or substituted 5-6 member heteroaryl group, or a substituted or substituted 9-10 member heteroaryl group. Here, the C which may be substituted 1~6 Alkyl, possibly substituted C 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 Cycloalkyls, optionally substituted 4-6 member heterocycloalkyls, optionally substituted phenyls, optionally substituted 5-6 member heteroaryls, or optionally substituted 9-10 member heteroaryls may contain halogens, nitros, or -R c, -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R c , -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may also be substituted with 1 to 4 substituents, each selected independently; If s is 0, R C1 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl, R C2 C may not exist or may be replaced. 1~4 Alkyl, where the substituted C 1~4 Alkyl groups are -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; If r is 1, R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2Together with it, it forms a linking group, where B is a bond, or B is a -halo(C 1~10 Alkyl)-, may be substituted-C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, optionally substituted C 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-, Here, the substitution may be made -C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl-C) 1~4 The alkyl part of alkyl)- is a halogen, halo(C 1~4 Alkyl), -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may be substituted with one or two substituents that are selected more independently of each other. The C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, -OP(O)(OR I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If s is 1, then W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with D, they form a linking group, where D is -halo(C 1~12 Alkyl)-, may be substituted-C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-, Here, the substitution may be made -C 1~12 Alkyl-, or possibly substituted-C 1~6 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)C 1~6 The alkyl part of alkyl- is a halogen, halo(C) 1~4 Alkyl), -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d-OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may be substituted with one or two substituents that are selected more independently of each other. The substitution may be made -C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, and C 1~4 Alkoxy-(C) 1~4 The alkoxy(-) group may be substituted with 1 to 4 substituents, each independently substituted; R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), -CH2N(R d )CO(R f ) or, R 3 and R 5 One of them is -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H, COOH, or -CO2R c and; R 4 and R 6 These are H, halogen, and halo (C) respectively, independently. 1~6 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -OP(O)(OH)2, OP(O)(R I R II )2, -NH2, -NR c R c , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g) SO2(C 1~2 Alkyl)-N(R h )(R f ), -N(R g )CO(C 1~2Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Selected from alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R c , -NR c R d -CO2H, -CO2R c , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R cThe group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may also be substituted with 1 to 4 substituents, each selected independently; R 14 C may be absent, or may be replaced by H, a halogen, or other C atoms. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d-SO2NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These, together with one or more atoms connecting them, form a 5-6 membered ring; or, R 16 and R 17 These, together with one or more atoms connecting them, form a 5-6 membered ring; R 18 and R 19 Each of these is independent and either nonexistent, H, halogen, or substituted C. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R17 and R 18 These, together with one or more atoms connecting them, form a 5-6 membered ring; R a H, -R c , -COR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -CH2-CO2R c , or -SO2NR c R d and; Each R b C is independent 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), or -(C 1~4 Alkyl)-CO-O-(C 1~4 Alkyl) is; Each R c H and C are independent of each other. 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C1~4 Alkyl)-O-CO(C 1~4 Alkyl), -(C 1~4 Alkyl)-CO-O-(C 1~4 C (alkyl), may be substituted. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 It is an alkyl-9~10 member heteroaryl, Here, the C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 Alkyl-9~10 member heteroaryl C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, 5-6 member heteroaryl moiety, or 9-10 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may also be substituted with 1 to 4 substituents, each selected independently; Each R d These are independently H, hydroxyl, or C 1~4 It is alkyl; Each R e H and (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -CO2(C 1~4 Alkyl), -(C 1~4 Alkyl)amino, -(C 1~4 Alkyl)-C 1~4 Alkoxy, -CO- (may be substituted 5-6 member heterocycloalkyl), -CO- (C 1~4 Alkyl)-(optionally substituted 5-6 member heterocycloalkyl), -CO-(optionally substituted 5-6 member heteroaryl), -CO-(C 1~4 Alkyl)-(may be substituted 5-6 member heteroaryl), Here, the optionally substituted 5-6 member heterocycloalkyl or optionally substituted 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)OP(O)(OH)2, -(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may also be substituted with 1 to 4 substituents, each selected independently; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R g and R h Each is independently H or (C 1~4 Alkyl) or R g and R h They, together with one or more atoms connecting them, form a 5-6 membered ring; and Each R I and R II (C 1~6 It is alkyl)oxy-; However, at least one of (i), (ii), or (iii) applies: (i) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S, or X9 is N; or (ii) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, then R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) s is 0 and r is 1, and (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2(C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0050] In some embodiments, the compound is a compound of formula (IA'), which is formula (IA), or a prodrug, solvate, pharmaceutically acceptable salt thereof, or tautomer: TIFF0007843695000031.tif73128.

[0051] In some respects, this disclosure provides compounds of formula (I'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers: TIFF0007843695000032.tif73128In formula, W1, X1, Y1, Z1, W2, X2, Y2, Z2, r, s, X3, X4, X5, X6, X9, R 3 , R 5 , R 14 , R a , R b , R c , R d , R e , R f , R I , and R II Each of these is defined independently for equation (IA'); If r is 0, B1 and R B2 Each of these is defined independently for equation (IA'); If s is 0, R C1 This is defined for equation (IA'); If r is 1, R B1 and R B2Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, they form a linking group, where B is a bond, or B is as defined for formula (IA'); If s is 1, then W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with it, they form a linking group, where D is as defined for formula (IA'); R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These, together with one or more atoms connecting them, form a 5-6 membered ring; R 18 and R 19 Each is independent, as defined for equation (IA'); or R 17 and R 18 They, together with one or more atoms connecting them, form a 5-6 membered ring; and R g and R h Each is independent, as defined for equation (IA'); or Rg and R h These, together with one or more atoms connecting them, form a 5-6 membered ring; However, at least one of (i), (ii), or (iii) of formula (IA') applies.

[0052] In some respects, this disclosure provides compounds of formula (I'), or prodrugs, solvates, pharmaceutically acceptable salts, or tautomers thereof; provided that at least one of (i), (ii), or (iii) applies: (i) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, then R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R cis H; or, (iii) s is 0 and r is 1, and (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 is hydroxy, substituted (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the replaced (C 1~6 Alkyl) and substituted (C 1~6 Alkyl)oxy-(C 1~6 Alkyl) is -OP(O)(OH)2, -OP(O)(R I R II )2, substituted with 1 to 4 substituents independently selected from optionally substituted phenyl and optionally substituted 5-6 membered heteroaryl groups, where the optionally substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; The substitution may be (C 1~6 Alkyl)amino- and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0053] In some embodiments, the compound is a compound of formula (I'), which is formula (I), or a prodrug, solvate, pharmaceutically acceptable salt thereof, or tautomer: TIFF0007843695000033.tif73128.

[0054] In some respects, this disclosure provides compounds of formula (II'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers: TIFF0007843695000034.tif69128In formula, W2, X2, Y2, Z2, r, s, X3, X4, X5, X6, X9, R 3 , R 4 , R 5 , R 6 , R a , R b , R c , R d , R e , R f , R I , and R II Each of these is independent, as defined in equation (IA'); If r is 0, B1 and R B2 Each of these is independent, as defined in equation (IA'); If s is 0, R C1 This is defined in equation (IA'); If r is 1, R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, they form a linking group, where B is a bond, or B is as defined in formula (IA'); If s is 1, then Z2 is C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with it, they form a linking group, where D is as defined in formula (IA'); R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R 17 C is either absent, or may be substituted with H, cyclopropyl, halogen, or C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; R 18 C may be absent, or may be substituted with H, a halogen, or other elements. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R dIt may be substituted with a more preferred substituent; or, R 17 and R 18 These, together with one or more atoms connecting them, form a 5-6 membered ring; R 19 C may be absent, or may be substituted with H, a halogen, or other elements. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; and R g and R h Each is independent, as defined in equation (IA'); or R g and R h These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0055] In some aspects, the present disclosure provides a compound of formula (II'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, wherein s is 0, r is 1, and (a) Z2 and Y2 are each N and W2 and X2 are each C; or (b) if W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N, and R A1 or R A2 is hydroxy, substituted (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the replaced (C 1~6 Alkyl) and substituted (C 1~6 Alkyl)oxy-(C 1~6 Alkyl) is -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl and optionally substituted 5-6 membered heteroaryl groups, where the optionally substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; The substitution may be (C 1~6 Alkyl)amino- and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0056] In some embodiments, the compound is a compound of formula (II'), which is formula (II), or a prodrug, solvate, pharmaceutically acceptable salt thereof, or tautomer: TIFF0007843695000035.tif68128.

[0057] In some respects, this disclosure provides compounds of formula (III'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers: TIFF0007843695000036.tif73128In formula, W1, X1, Y1, Z1, W2, X2, Y2, Z2, s, X3, X4, X5, X6, X9, R 3 , R 4 R 5 , R 6 , R 14 , R a , R b , R c , R d , R e , R f , R I , and R II Each of these is independent, as defined in equation (IA'); If s is 0, R C1 This is defined in equation (IA'); If s is 1, then W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with it, they form a linking group, where D is as defined in formula (IA'); R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONRc R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These, together with one or more atoms connecting them, form a 5-6 membered ring; R 18 and R 19 Each is defined independently in this specification; or, R 17 and R 18 They, together with one or more atoms connecting them, form a 5-6 membered ring; and R g and R h Each is independent, as defined in equation (IA'); or R g and R h These, together with one or more atoms connecting them, form a 5-6 membered ring; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) If s is 0, and (a) Z1, Z2, Y1, and Y2 are each N, and W1, W2, X1, and X2 are each C; or (b) if W1, W2, X1, and X2 are each N, and Z1, Z2, Y1, and Y2 are each C, then R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) s is 0, and (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N, and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-, where the substituted (C) 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(RI R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0058] In some embodiments, the compound is a compound of formula (III'), which is formula (III), or a prodrug, solvate, pharmaceutically acceptable salt thereof, or tautomer: TIFF0007843695000037.tif64128.

[0059] In some aspects, this disclosure provides compounds of formula (IV'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers: TIFF0007843695000038.tif73128In formula, W1, X1, Y1, Z1, W2, X2, Y2, Z2, r, s, X3, X4, X5, X6, X9, R 3 , R 4 R 5 , R 6 , R 14 , R 18 , R 19 , R a , R b , R c , R d , R e , R f , R I , and R II Each is independent If r is 0, B1 and R B2 Each of these is independent, as defined in equation (IA'); If s is 0, R C1 This is defined in equation (IA'); If r is 1, R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, they form a linking group, where B is a bond, or B is as defined in formula (IA'); If s is 1, then W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with it, they form a linking group, where D is as defined in formula (IA'); R 16 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl; R15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 They, together with one or more atoms connecting them, form a 5-6 membered ring; and R g and R h Each is independent, as defined in equation (IA'); or R g and R h These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0060] In some embodiments, the compound is a compound of formula (IV'), which is formula (IV), or a prodrug, solvate, pharmaceutically acceptable salt thereof, or tautomer: TIFF0007843695000039.tif73128.

[0061] In some embodiments, the compound is a compound of formula (V'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000040.tif69128In formula, Y1, Y2, Z1, and Z2 are each independently O, S, C, or N; X1, X2, W1, and W2 are each independently either C or N; X3 and X4 are independently S or NR f and; X5 is N or CR A2 and; X6 is N or CR A1 and; X9 is N or CH; R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), -CH2N(R d )CO(R f ) or R 3 and R 5 One of them is -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H, -COOH, or -CO2R C and; R c is C 1~4 It is alkyl; R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy1~6 Alkyl is hydroxy, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), and may be substituted with 1 to 4 substituents independently selected from the group including -COOH; Each R d These are independently H, hydroxyl, or C 1~4 It is alkyl; R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), and -CO2(C 1~4 Selected from alkyl groups; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R 14 and R C2 Each is independent, either non-existent or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; R 16 and R C1 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl; and R 15 , R 17 , R 18 , or R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -ORc , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may also be substituted with more preferred substituents; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl) or substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), and may be substituted with 1 to 4 substituents independently selected from the group including -COOH.

[0062] In some embodiments, the compound is a compound of formula (V'), which is formula (V), or a prodrug, solvate, pharmaceutically acceptable salt thereof, or tautomer: TIFF0007843695000041.tif69128.

[0063] In some respects, this disclosure provides compounds of formula (I'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers, where Y1, Y2, Z1, and Z2 are each independently O, S, C, or N; X1, X2, W1, and W2 are each independently either C or N; R A1 and R A2 These are independently H, halogen, hydroxyl, -OP(O)(OH)2, and -OP(O)(R) I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; However, at least one of (i), (ii), or (iii) applies: (i) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, then R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) s is 0 and r is 1, and (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2(C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-, where the substituted (C) 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0064] In some respects, this disclosure provides compounds of formula (I'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers, where R A1 and R A2 These are independently H, halogen, hydroxyl, and -N(R) e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, C1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-, Halo(C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If r is 0, B1 and R B2 Each of these is independently H, and C may be substituted. 1~6 Alkyl, Halo(C) 1~6 C (alkyl), may be substituted. 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 The cycloalkyl group is a substituted or substituted 4-6 member heterocycloalkyl group, a substituted or substituted phenyl group, a substituted or substituted 5-6 member heteroaryl group, or a substituted or substituted 9-10 member heteroaryl group. Here, the C which may be substituted 1~6 Alkyl, possibly substituted C 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6Cycloalkyls, optionally substituted 4-6 member heterocycloalkyls, optionally substituted phenyls, optionally substituted 5-6 member heteroaryls, or optionally substituted 9-10 member heteroaryls may contain halogens, nitros, or -R c -OH, -OR c -NH2, -NR C R C , -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may also be substituted with 1 to 4 substituents, each selected independently; If r is 1, R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, it forms a linking group, where B is a bond, or B is a -halo(C 1~10 Alkyl)-, may be substituted-C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, optionally substituted C 3~6Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-, Here, the substitution may be made -C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl-C) 1~4 The alkyl part of alkyl)- is a halogen, halo(C 1~4 Alkyl), -OH, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c-CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may be substituted with one or two substituents that are selected more independently of each other. The C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, aminos, or (C) 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4They may be substituted with 1 to 4 substituents independently selected from each alkoxy; If s is 1, then W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with D, they form a linking group, where D is -halo(C 1~12 Alkyl)-, may be substituted-C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-, Here, the substitution may be made -C 1~12 Alkyl-, or possibly substituted-C 1~6 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)C 1~6 The alkyl part of alkyl- is a halogen, halo(C) 1~4 Alkyl), -OH, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may be substituted with one or two substituents that are selected more independently of each other. The substitution may be made -C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-C 3~6The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, aminos, or (C) 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 The alkoxy(-) group may be substituted with 1 to 4 substituents, each independently substituted; R 4 and R 6 These are H, halogen, and halo (C) respectively, independently. 1~6 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -NH2, -NR C R C , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g) SO2(C 1~2 Alkyl)-N(R h )(R f ), -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Selected from alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OR c -NH2, -NR C R C , -NR c R d -CO2H, -CO2R c , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-, Halo(C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, C 1~4 Alkoxy-(C)1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may also be substituted with 1 to 4 substituents, each selected independently; Each R b C is independent 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), or -(C 1~4 Alkyl)-CO-O-(C 1~4 Alkyl) is; Each R c H and C are independent of each other. 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), -(C 1~4 Alkyl)-CO-O-(C 1~4 C (alkyl), may be substituted. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 It is an alkyl-9~10 member heteroaryl, Here, the C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 Alkyl-9~10 member heteroaryl C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, 5-6 member heteroaryl moiety, or 9-10 member heteroaryl moiety may contain halogen, hydroxyl, amino, or -(C) 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents that are selected independently of each other; and Each R e H and (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -CO2(C 1~4Alkyl), -CO- (may be substituted 5-6 member heterocycloalkyl), -CO- (C 1~4 Alkyl)-(optionally substituted 5-6 member heterocycloalkyl), -CO-(optionally substituted 5-6 member heteroaryl), -CO-(C 1~4 Alkyl)-(may be substituted 5-6 member heteroaryl), Here, the optionally substituted 5-6 member heterocycloalkyl or optionally substituted 5-6 member heteroaryl is a halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents selected independently of each other; provided that at least one of (i), (ii), or (iii) applies: (i) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) s is 0 and r is 1, and (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, then R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) s is 0 and r is 1, and (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-, where the substituted (C) 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0065] The alternative definitions of the various groups and substituents of formula (I'), formula (IA'), formula (II'), formula (III'), formula (IV'), or formula (V') shown throughout this specification are intended to describe each compound species disclosed herein individually and to describe groups consisting of one or more compound species. The scope of this disclosure includes any combination of these group and substituent definitions. As those skilled in the art will recognize, the compounds in this disclosure are only those assumed to be "chemically stable."

[0066] Those skilled in the art will recognize that the compounds of this disclosure may exist in other tautomers, including zwitterionic forms, or other isomers. All tautomers (including zwitterionic forms) and isomers of the formulas and compounds described herein are intended to be encompassed within the scope of this disclosure.

[0067] Furthermore, those skilled in the art will recognize that the compounds of this disclosure may exist in tautomeristic forms including, but not limited to, formula (A), formula (B), formula (C), formula (D), and / or formula (E), or in zwitterionic forms including, but not limited to, formula (F), formula (G), or formula (H): TIFF0007843695000042.tif83161.

[0068] In some embodiments, when r is 1 and s is 0 (the sum of r and s is 1), the compounds of the present disclosure are compounds of formula (I-B') or formula (I-b'): In formula TIFF0007843695000043.tif70128, X7 and X8 are independently either C=O or CH2.

[0069] In some embodiments, the compounds of the present disclosure are compounds of formula (I-B') or formula (I-b'), where X9 is CR. 4 That is the case.

[0070] In some embodiments, when r is 0 and s is 1 (the sum of r and s is 1), W1 and Z2 are independently C or N, and the compounds of the present disclosure are compounds of formula (I-D') or formula (I-d'): In formula TIFF0007843695000044.tif70128, X7 and X8 are independently either C=O or CH2.

[0071] In some embodiments, the compounds of the present disclosure are compounds of formula (I-D') or formula (I-d'), where X9 is CR. 4 That is the case.

[0072] In some embodiments, when r is 1 and s is 1 (the sum of r and s is 2), W1 and Z2 are independently C or N, and the compounds of the present disclosure are compounds of formula (I-BD') or formula (I-bd'): In formula TIFF0007843695000045.tif68128, X7 and X8 are independently either C=O or CH2.

[0073] In some embodiments, the compounds of the present disclosure are compounds of formula (I-BD') or formula (I-bd'), where X9 is CR. 4 That is the case.

[0074] For compounds of formula (I'), formula (IA'), formula (II'), formula (III'), formula (IV'), or formula (V'), it should be understood that, if appropriate, the following applies:

[0075] In some embodiments, W1, X1, Y1, Z1, W2, X2, Y2, and Z2 are each independently O, S, C, or N.

[0076] In some embodiments, W1, X1, Y1, and Z1 are each independently O, S, C, or N.

[0077] In some embodiments, W1, X1, Y1, and Z1 are each independently O, C, or N. In some embodiments, W1, X1, Y1, and Z1 are each independently S, C, or N. In some embodiments, W1, X1, Y1, and Z1 are each independently O, S, or C. In some embodiments, W1, X1, Y1, and Z1 are each independently O, S, or N.

[0078] In some embodiments, W1 is O, S, C, or N. In some embodiments, W1 is O. In some embodiments, W1 is S. In some embodiments, W1 is C. In some embodiments, W1 is N.

[0079] In some embodiments, X1 is O, S, C, or N. In some embodiments, X1 is O. In some embodiments, X1 is S. In some embodiments, X1 is C. In some embodiments, X1 is N.

[0080] In some embodiments, Y1 is O, S, C, or N. In some embodiments, Y1 is O. In some embodiments, Y1 is S. In some embodiments, Y1 is C. In some embodiments, Y1 is N.

[0081] In some embodiments, Z1 is O, S, C, or N. In some embodiments, Z1 is O. In some embodiments, Z1 is S. In some embodiments, Z1 is C. In some embodiments, Z1 is N.

[0082] In some embodiments, W2, X2, Y2, and Z2 are each independently O, S, C, or N.

[0083] In some embodiments, W2, X2, Y2, and Z2 are each independently O, C, or N. In some embodiments, W2, X2, Y2, and Z2 are each independently S, C, or N. In some embodiments, W2, X2, Y2, and Z2 are each independently O, S, or C. In some embodiments, W2, X2, Y2, and Z2 are each independently O, S, or N.

[0084] In some embodiments, W2 is O, S, C, or N. In some embodiments, W2 is O. In some embodiments, W2 is S. In some embodiments, W2 is C. In some embodiments, W2 is N.

[0085] In some embodiments, X2 is O, S, C, or N. In some embodiments, X2 is O. In some embodiments, X2 is S. In some embodiments, X2 is C. In some embodiments, X2 is N.

[0086] In some embodiments, Y2 is O, S, C, or N. In some embodiments, Y2 is O. In some embodiments, Y2 is S. In some embodiments, Y2 is C. In some embodiments, Y2 is N.

[0087] In some embodiments, Z2 is O, S, C, or N. In some embodiments, Z2 is O. In some embodiments, Z2 is S. In some embodiments, Z2 is C. In some embodiments, Z2 is N.

[0088] In some embodiments, X3 and X4 are independently S or NR f That is the case.

[0089] In some embodiments, X3 and X4 are independently S. In some embodiments, X3 and X4 are independently NR f That is the case.

[0090] In some embodiments, X3 is S or NRf In some embodiments, X3 is S. In some embodiments, X3 is NR f That is the case.

[0091] In some embodiments, X4 is S or NR f In some embodiments, X4 is S. In some embodiments, X4 is NR f That is the case.

[0092] In some embodiments, r is 0 or 1. In some embodiments, r is 0. In some embodiments, r is 1.

[0093] In some embodiments, s is 0 or 1. In some embodiments, s is 0. In some embodiments, s is 1.

[0094] In some embodiments, p is 1 or 2. In some embodiments, p is 1. In some embodiments, p is 2.

[0095] In some embodiments, if r is 0, then B does not exist, and R B1 and R B2 It is not connected.

[0096] In some embodiments, if s is 0, then D does not exist, and R C1 and R C2 It is not connected.

[0097] In some embodiments of the compounds disclosed herein, R A1 and R A2 These are independently H, halogen, hydroxyl, and -N(R) e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-, Halo-(C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0098] In some embodiments of the compounds disclosed herein, R A1 and RA2 Each is independently hydroxyl, substituted (C 1~6 Alkyl), substitution (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the replaced (C 1~6 Alkyl) and substituted (C 1~6 Alkyl)oxy-(C 1~6 Alkyl) is -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl and optionally substituted 5-6 membered heteroaryl groups, where the optionally substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4They may be substituted with 1 to 4 substituents independently selected from each alkoxy; The substitution may be (C 1~6 Alkyl)amino- and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0099] In some embodiments of the compounds disclosed herein, R A1 and R A2 These are independently H, halogen, hydroxyl, -OP(O)(OH)2, and -OP(O)(R) I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0100] In some embodiments of the compounds disclosed herein, R A1 and R A2 These are independently H, halogen, hydroxyl, amino, and (C) 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, (C 1~4 Alkyl), hydroxy(C 1~4 Alkyl)-, amino(C 1~4 (Alkyl)-, (C 1~4 Alkyl)amino(C 1~4 (Alkyl)-, (C 1~4 Alkyl)(C1~4 Alkyl)amino(C 1~4 Alkyl)-, C 1~4 Alkoxyl, Hydroxyl (C 2~4 Alkoxyl)-, amino(C 2~4 Alkoxyl)-, (C 1~4 Alkyl)amino(C 2~4 Alkoxyl)-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino(C 2~4 Alkoxyl)-, 6-membered heterocycloalkyl-(C 1~4 Alkyl)-, Phenyl(C 1~4 Alkoxy)-, (C 1~4 Alkyl)OCONH(C 1~4 Alkyl)-, hydroxy(C 1~4 Alkyl)amino-, (C 1~4 Alkyl)CONH-, (C 1~4 Alkyl)CON(C 1~4 Alkyl)-, -CO2H, -CO2(C 1~4 Alkyl), amino(C 1~4 Alkyl)CONH-, (C 1~4 Alkyl)amino(C 1~4 Alkyl)CONH-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino(C 1~4 Alkyl)CONH-, amino(C 1~4 Alkyl)CON(C 1~4 (Alkyl)-, (C 1~4 Alkyl)amino(C 1~4 Alkyl)CON(C 1~4 Alkyl)-, hydroxy(C 1~4 Alkyl)CONH-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino(C 1~4 Alkyl)CON(C 1~4 Alkyl)-, hydroxy(C 1~4 Alkyl)CON(C 1~4 Alkyl)-, HO2C(C 1~4 Alkoxy)-, (C 1~4 Alkyl)OCO(C 1~4 Alkoxy)-, H2NCO(C 1~4Alkoxy)-, (C 1~4 Alkyl)HNCO(C 1~4 Alkoxy)-, (C 1~4 Alkyl)(C 1~4 Alkyl)NCO(C 1~4 Alkoxy)-, and -NHSO2(C 1~4 It is alkyl-.

[0101] In some embodiments of the compounds disclosed herein, R A1 and R A2 These are independently H, halogen, hydroxyl, -OP(O)(OH)2, and -OP(O)(R) I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, (C 1~4 Alkyl), hydroxy(C 1~4 Alkyl)-, amino(C 1~4 (Alkyl)-, (C 1~4 Alkyl)amino(C 1~4 (Alkyl)-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino(C 1~4 Alkyl)-, C 1~4 Alkoxy-, Hydroxy(C) 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy-OP(O)(R I R II )2, amino(C 2~4 Alkoxy)-, (C 1~4 Alkyl)amino(C 2~4 Alkoxy)-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino(C 2~4 Alkoxy)-, 6-membered heterocycloalkyl-(C 1~4 Alkyl)-, Phenyl(C 1~4 Alkoxy)-, (C 1~4 Alkyl)OCONH(C 1~4 Alkyl)-, hydroxy(C 1~4 Alkyl)amino-, -amino(C1~4 Alkyl)-OP(O)(OH)2,-amino(C 1~4 Alkyl)-OP(O)(R I R II )2, (C 1~4 Alkyl)CONH-, (C 1~4 Alkyl)CON(C 1~4 Alkyl)-, -CO2H, -CO2(C 1~4 Alkyl), amino(C 1~4 Alkyl)CONH-, (C 1~4 Alkyl)amino(C 1~4 Alkyl)CONH-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino(C 1~4 Alkyl)CONH-, amino(C 1~4 Alkyl)CON(C 1~4 (Alkyl)-, (C 1~4 Alkyl)amino(C 1~4 Alkyl)CON(C 1~4 Alkyl)-, hydroxy(C 1~4 Alkyl)CONH-,-NHCO(C 1~4 Alkyl)-OP(O)(OH)2,-NHCO(C 1~4 Alkyl)-OP(O)(R I R II )2, (C 1~4 Alkyl)(C 1~4 Alkyl)amino(C 1~4 Alkyl)CON(C 1~4 Alkyl)-, hydroxy(C 1~4 Alkyl)CON(C 1~4 Alkyl)-,-(C 1~4 Alkyl)NCO(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)NCO(C 1~4 Alkyl)-OP(O)(R I R II )2, HO2C(C 1~4 Alkoxy)-, (C 1~4 Alkyl)OCO(C 1~4 Alkoxy)-, H2NCO(C 1~4 Alkoxy)-, (C 1~4 Alkyl)HNCO(C1~4 Alkoxy)-, (C 1~4 Alkyl)(C 1~4 Alkyl)NCO(C 1~4 Alkoxy)-, and -NHSO2(C 1~4 It is alkyl-.

[0102] In some embodiments, R A1 and R A2 These are H, halogen, and (C) respectively, independently. 1~6 Alkyl)oxy-, hydroxy(C 2~6 Alkyl)oxy-, HO(O)C-(C 2~6 Alkyl)oxy-, amino(C 2~6 Alkyl)oxy-, hydroxy, amino, or amino(C 1~4 It is alkyl-.

[0103] In some embodiments, R A1 and R A2 These are independently H, halogen, hydroxyl, and (C) 1~6 Alkyl)oxy-, hydroxy(C 2~6 Alkyl)oxy-,-(C 2~4 Alkoxy)-OP(O)(OH)2, or -(C 2~4 Alkoxy)-OP(O)(R I R II )2.

[0104] In some embodiments, R A1 and R A2 Each of these is independently H. In some embodiments, R A1 and R A2 These are H.

[0105] In some embodiments, R A1 and R A2 Each of these is an independent halogen. In some embodiments, R A1 and R A2 These are all halogens.

[0106] In some embodiments, R A1 and RA2 These are each -OCH2CH2CH2NH2.

[0107] In some embodiments, R A1 and R A2 These are independently H, halogen, hydroxyl, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, or -N(R e )(R f )

[0108] In some embodiments, R A1 and R A2 The is -OCH3, and R A1 and R A2 The other of these is halogen, -OH, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, or -N(R e )(R f )

[0109] In some embodiments, R A1 and R A2 H is R A1 and R A2 The other of these is halogen, -OH, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, or -N(R e )(R f )

[0110] In some embodiments, R A1 and R A2 The is -OCH3, and R A1 and R A2 The other of these is -OCH2CH2CH2OH.

[0111] In some embodiments, R A1 and R A2 The is -OCH3, and R A1 and R A2 The other of these is -OCH2CH2CH2COOH.

[0112] In some embodiments, R A1 and R A2 H is R A1 and R A2 The other of these is -OCH2CH2CH2OH.

[0113] In some embodiments, R A1 and R A2 The is -OCH3, and R A1 and R A2 The other of these is -OCH2CH2CH2NH2.

[0114] In some embodiments, R A1 and R A2 The is -OH, and R A1 and R A2 The other of these is -OCH2CH2CH2OH.

[0115] In some embodiments, R A1 and R A2 The is -OH, and R A1 and R A2 The other of these is -OCH2CH2CH2COOH.

[0116] In some embodiments, R A1 and R A2 The is -OH, and R A1 and R A2 The other of these is -OCH2CH2CH2NH2.

[0117] In some embodiments, R A1 H, halogen, amino, amino(C) 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e)(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0118] In some embodiments, R A1 H is H.

[0119] In some embodiments, R A1 is halogen, amino, amino(C 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C)1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0120] In some embodiments, R A1 is a halogen. In some embodiments, R A1 is F, Cl, Br, or I. In some embodiments, R A1 is F, Cl, or Br. In some embodiments, R A1 is F. In some embodiments, R A1 is Cl. In some embodiments, R A1 It is Br.

[0121] In some embodiments, R A1 is amino, amino(C 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0122] In some embodiments, R A1is amino or amino(C) 1~4 Alkyl)-, where the substituted (C) 1~6 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0123] In some embodiments, R A1 hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0124] In some embodiments, R A1 (C) 1~6 Alkyl)oxy-, where the substituted (C 1~6 Alkyl)oxy-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(Rf ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0125] In some embodiments, R A1 is replaced (C 1~6 It is alkyl)oxy-, where the substituted (C 1~6 Alkyl)oxy-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R)e )(R f ), -CO2(R f ), -CON(R e )(R f ), is substituted with 1 to 4 substituents independently selected from optionally substituted phenyl and optionally substituted 5-6 membered heteroaryl groups, where the optionally substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0126] In some embodiments, R A1 is replaced (C 1~6 It is alkyl)oxy-, where the substituted (C 1~6 Alkyl)oxy-(C 1~6 The alkyl group is substituted with hydroxyl. In some embodiments, R A1It is -OCH2CH2CH2OH.

[0127] In some embodiments, R A1 is hydroxy(C 2~6 It is alkyl)oxy-. In some embodiments, R A1 is HO(O)C-(C 2~6 It is alkyl)oxy-. In some embodiments, R A1 It is -OCH2CH2CH2COOH.

[0128] In some embodiments, R A1 is amino(C) 2~6 It is alkyl)oxy-. In some embodiments, R A1 It is -OCH2CH2CH2NH2.

[0129] In some embodiments, R A1 is (C 1~6 It is alkyl)oxy-. In some embodiments, R A1 It is (methyl)oxy- (i.e., methoxy).

[0130] In some embodiments, R A1 is -OH. In some embodiments, R A1 It is an amino acid.

[0131] In some embodiments, R A1 is amino(C) 1~4 It is alkyl-.

[0132] In some embodiments, R A2 and R A1 These are independently H, halogen, hydroxyl, amino, and amino(C) 1~4 Alkyl)-, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 Alkyl)oxy-, where the substituted (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6Alkyl is hydroxy, -OP(O)(OH)2, C 1~4 Alkoxyl, -N(R e )(R f Each R may be substituted with 1 to 4 substituents independently selected from the group including ), -COOH, and optionally substituted phenyl, and each R e H and C are independent of each other. 1~4 Alkyl, -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -(C 1~4 Alkyl)NH2, -(C 1~4 Alkyl)(C 1~4 Alkoxy), and -CO2(C 1~4 Selected from alkyl groups.

[0133] In some embodiments, R A2 and R A1 These are independently H, halogen, hydroxyl, amino, and amino(C) 1~4 Alkyl)-, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, and the substituted (C) is also alkyl. 1~6 Alkyl), may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), C 1~4 Each R may be substituted with 1 to 4 substituents independently selected from the group comprising alkoxyl, phenyl, and substituted 5-6 member heteroaryls containing at least one nitrogen or oxygen as a ring member, and each R e H and C are independent of each other. 1~4 Alkyl, -(C 1~4 Alkyl)NH2, and -(C 1~4 Alkyl)C 1~4 Selected from alkoxy.

[0134] In some embodiments, RA2 or R A1 At least one of them is independently H, hydroxy, halogen, amino, or amino(C) 1~4 Alkyl)-, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, and the substituted (C) is also alkyl. 1~6 Alkyl), may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is -N(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from tetrahydropyran, pyrrolidinyl, piperazinyl, piperidyl, and morpholinyl, each R e H and C are independent of each other. 1~4 Alkyl, -(C 1~4 Alkyl)NH2, and -(C 1~4 Alkyl)C 1~4 Selected from alkoxy.

[0135] In some embodiments, R A2 or R A1 At least one of them is independently H, hydroxy, halogen, amino, or amino(C) 1~4 Alkyl)-, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, and the substituted (C) is also alkyl. 1~6 Alkyl), may be substituted (C 1~6 C of alkyl)oxy 1~6 The alkyl group may be substituted with 1 to 4 substituents independently selected from tetrahydropyran, pyrrolidinyl, piperazinyl, piperidyl, and morpholinyl, and each R e H and C are independent of each other. 1~4 Selected from alkyl groups.

[0136] In some embodiments, R A2 H, halogen, amino, amino(C) 1~4Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I RII )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0137] In some embodiments, R A2 H is H.

[0138] In some embodiments, R A2 is halogen, amino, amino(C 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h)(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0139] In some embodiments, R A2 is a halogen. In some embodiments, R A2 is F, Cl, Br, or I. In some embodiments, R A2 is F, Cl, or Br. In some embodiments, R A2 is F. In some embodiments, R A2 is Cl. In some embodiments, R A2 It is Br.

[0140] In some embodiments, R A2 is amino, amino(C 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2R f , -N(R f )COR b , -N(R g )SO2(C 1~4 Alkyl)-N(R e )(R f ), -N(R g )CO(C 1~4 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(RI R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0141] In some embodiments, R A2 is amino or amino(C) 1~4 Alkyl)-, where the substituted (C) 1~6 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0142] In some embodiments, R A2 (C) 1~6 Alkyl)oxy-, where the substituted (C 1~6 Alkyl)oxy-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0143] In some embodiments, R A2 is replaced (C 1~6 It is alkyl)oxy-, where the substituted (C 1~6 Alkyl)oxy-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxy-, -N(R) e )(R f ), -CO2(R f ), -CON(R e )(R f ), is substituted with 1 to 4 substituents independently selected from optionally substituted phenyl and optionally substituted 5-6 membered heteroaryl groups, where the optionally substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0144] In some embodiments, R A2 is replaced (C 1~6 It is alkyl)oxy-, where the substituted (C 1~6 Alkyl)oxy-(C 1~6 The alkyl group is substituted with hydroxyl. In some embodiments, R A2 It is -OCH2CH2CH2OH.

[0145] In some embodiments, R A2 is hydroxy(C 2~6 It is alkyl)oxy-. In some embodiments, R A2 is HO(O)C-(C 2~6 It is alkyl)oxy-. In some embodiments, R A2 It is -OCH2CH2CH2COOH.

[0146] In some embodiments, R A2 is amino(C) 2~6 It is alkyl)oxy-. In some embodiments, R A2 It is -OCH2CH2CH2NH2.

[0147] In some embodiments, R A2 is (C 1~6 It is alkyl)oxy-. In some embodiments, R A2 It is (methyl)oxy- (i.e., methoxy).

[0148] In some embodiments, R A2 is -OH. In some embodiments, R A2 It is an amino acid.

[0149] In some embodiments, R A2 is amino(C) 1~4 It is alkyl-.

[0150] In some embodiments, r is 0, and R B1 and R B2 Each of these is independently H, and C may be substituted. 1~6 Alkyl, Halo(C) 1~6 C (alkyl), may be substituted. 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 The cycloalkyl group is a substituted or substituted 4-6 member heterocycloalkyl group, a substituted or substituted phenyl group, a substituted or substituted 5-6 member heteroaryl group, or a substituted or substituted 9-10 member heteroaryl group. Here, the C which may be substituted 1~6 Alkyl, possibly substituted C 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 Cycloalkyls, optionally substituted 4-6 member heterocycloalkyls, optionally substituted phenyls, optionally substituted 5-6 member heteroaryls, or optionally substituted 9-10 member heteroaryls may contain halogens, nitros, or -R c -OH, -OR c -NH2, -NR C R C , -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d-OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may be substituted with 1 to 4 substituents, each selected independently.

[0151] In some embodiments, r is 0, and R B1 and R B2 These are H.

[0152] In some embodiments, r is 0, and R B1 and R B2 Each of these is independently H, and C may be substituted. 1~6 Alkyl, Halo(C) 1~6 C (alkyl), may be substituted. 2~6 Alkenyl, C may be substituted 2~6 Alkynyl, C may be substituted. 3~6 The components are cycloalkyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, or optionally substituted 9 member heteroaryl.

[0153] In some embodiments, s is 0, W1 and Z2 are independently C or N, and R C1 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl, R C2 C may not exist or may be replaced. 1~4 Alkyl, where the substituted C 1~4 Alkyl groups are -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONRc R d They may be substituted with more selective substituents.

[0154] In some embodiments of the compounds disclosed herein, when s is 0, W1 and Z2 are independently C or N, and R C1 and R C2 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl. In some embodiments, when s is 0, W1 is C and R C1 is C 1~3 Alkyl, specifically methyl. In some embodiments, when s is 0, Z2 is C or N, and R C2 is C 1~3 Alkyl, specifically methyl or ethyl. In some embodiments, when s is 0, Z2 is C or N, and R C2 It is ethyl.

[0155] In some embodiments of the compounds disclosed herein, s is 0, W1 is C, Z2 is O or S, and R C1 It either does not exist, or it is H, halogen, or C 1~4 It is alkyl, R C2 It does not exist.

[0156] In some embodiments of the compounds disclosed herein, when s is 0, W1 is C, Z2 is O or S, and R C1 It does not exist, or it is H or C 1~4 It is alkyl, R C2 It does not exist. In some embodiments, if s is 0, then W1 is C and R C1 is C 1~3 Alkyl, specifically methyl. In some embodiments, when s is 0, Z2 is O or S, and R C2 is C 1~3 Alkyl, specifically methyl or ethyl. In some embodiments, when s is 0, Z2 is O or S, and R C2 It is ethyl.

[0157] In some embodiments of the compounds disclosed herein, r is 1, and R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, it forms a linking group, where B is a bond, or B is a -halo(C 1~10 Alkyl)-, may be substituted-C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, optionally substituted C 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-, Here, the substitution may be made -C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~4Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl-C) 1~4 The alkyl part of alkyl)- is a halogen, halo(C 1~4 Alkyl), -OH, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c The C may be substituted with one or two substituents that are selected more independently of each other. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)-C 1~4 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, aminos, or (C) 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, -C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, -C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0158] In some embodiments of the compounds disclosed herein, r is 1, and R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, it forms a linking group, where B is a bond, or B is a -halo(C 1~10 Alkyl)-, may be substituted-C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, optionally substituted C 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)C 1~4 Alkyl-, Here, the substitution may be made -C 1~10 Alkyl-, or possibly substituted-C 2~10 Alkenyl-, may be substituted-C 2~10 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl-C) 1~4 The alkyl part of alkyl)- is a halogen, halo(C 1~4 Alkyl), -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d-OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d , and -NR d SO2R c The C may be substituted with one or two substituents that are selected more independently of each other. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted -C 1~4 Alkyl-(C 3~6 Cycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-phenyl-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(4-6 member heterocycloalkyl)-C 1~4 Alkyl-, or possibly substituted-C 1~4 Alkyl-(5-6 member heteroaryl)C 1~4 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, -C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, -C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and -C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0159] In some embodiments of the compounds disclosed herein, r is 1, and R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, it forms a 2-6 membered linking group. In a further embodiment, r is 1, and R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, it forms a 3-6 membered linking group. In a further embodiment, r is 1, and R B1 and R B2 Each of them is independently -CH2-, and B is R B1 and R B2 Together with it, they form a 4-5 membered linking group.

[0160] In some embodiments, B is a combination.

[0161] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~10 Alkyl group or unsubstituted C 1~10 Alkyl-, -C 2~10 Alkenyl-, -C 2~10 Alkinyl-, -C 1~6 Alkyl-OC 1~6 Alkyl-, or -C 1~6 Alkyl-NR a -C 1~6 It is an alkyl group, where the substituted -C 1~10 The alkyl group is a halogen, hydroxy, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), Halo (C 1~4 Alkoxy)-, -C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, -C 1~4 Alkoxy-(C) 1~4Alkoxy)-,-NHCO(C 1~4 (C) is substituted with 1 to 4 substituents independently selected from alkyl, optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl is a halogen, hydroxyl, amino, or (C) 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), Halo (C 1~4 Alkoxy)-, -C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0162] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~10 Alkyl group or unsubstituted C 1~10 Alkyl-, -C 2~10 Alkenyl-, -C 2~10 Alkinyl-, -C 1~6 Alkyl-OC 1~6 Alkyl-, or -C 1~6 Alkyl-NR a -C 1~6 It is an alkyl group, where the substituted -C 1~10 The alkyl group is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), Halo (C 1~4 Alkoxy)-, -C 1~4Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-,-NHCO(C 1~4 It is substituted with 1 to 4 substituents independently selected from alkyl, optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0163] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~10 Alkyl group or unsubstituted C 1~10 Alkyl-, -C 2~10 Alkenyl-, -C 2~10 Alkinyl-, -C 1~6 Alkyl-OC 1~6 Alkyl-, or -C 1~6 Alkyl-NR a -C 1~6 It is an alkyl group, where the substituted -C 1~10 The alkyl group is a halogen, hydroxy, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with 1 to 4 substituents independently selected from the alkoxy group.

[0164] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~10 Alkyl group or unsubstituted C 1~10 Alkyl-, -C 2~10 Alkenyl-, -C 2~10 Alkinyl-, -C 1~6 Alkyl-OC 1~6 Alkyl-, or -C 1~6 Alkyl-NR a -C 1~6 It is an alkyl group, where the substituted -C 1~10 The alkyl group is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with 1 to 4 substituents independently selected from the alkoxy group.

[0165] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~8 Alkyl group or unsubstituted C 1~8 Alkyl-, -C 2~8 Alkenyl-, -C 2~8 Alkinyl-, -C 1~4 Alkyl-OC 1~4 Alkyl-, or -C 1~4 Alkyl-NRa -C 1~4 It is an alkyl group, where the substituted -C 1~8 The alkyl group is a halogen, hydroxy, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with 1 to 4 substituents independently selected from the alkoxy group.

[0166] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~8 Alkyl group or unsubstituted C 1~8 Alkyl-, -C 2~8 Alkenyl-, -C 2~8 Alkinyl-, -C 1~4 Alkyl-OC 1~4 Alkyl-, or -C 1~4 Alkyl-NR a -C 1~4 It is an alkyl group, where the substituted -C 1~8 The alkyl group is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with 1 to 4 substituents independently selected from the alkoxy group.

[0167] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~6Alkyl group or unsubstituted C 1~6 Alkyl-, -C 2~6 Alkenyl-, -C 2~6 Alkinyl-, -C 1~2 Alkyl-OC 1~2 Alkyl-, or -C 1~2 Alkyl-NR a -C 1~2 It is an alkyl group, where the substituted -C 1~6 The alkyl group is a halogen, hydroxy, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0168] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 1~6 Alkyl group or unsubstituted C 1~6 Alkyl-, -C 2~6 Alkenyl-, -C 2~6 Alkinyl-, -C 1~2 Alkyl-OC 1~2 Alkyl-, or -C 1~2 Alkyl-NR a -C 1~2 It is an alkyl group, where the substituted -C 1~6 The alkyl group is a halogen, hydroxy, -OP(O)(OH)2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0169] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 2~4 Alkyl group or unsubstituted C 2~4 Alkyl-, -C 2~4 Alkenyl-, -C 2~4 Alkinyl-, -C 1~4 Alkyl-OC 1~4 Alkyl-, or -C 1~4 Alkyl-NR a -C 1~4 It is an alkyl group, where the substituted -C 1~4 The alkyl group is a halogen, hydroxy, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0170] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is a substituted -C 2~4 Alkyl group or unsubstituted C 2~4 Alkyl-, -C 2~4 Alkenyl-, -C 2~4 Alkinyl-, -C1alkyl-O-C1alkyl-, or -C1alkyl-NR a -C1 alkyl- group, where the substituted -C 2~4 The alkyl group is a halogen, hydroxy, -OP(O)(OH)2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0171] In some embodiments, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is -CH=CH-, -CH2CH2-, -CH(OH)CH(OH)-, or -CH2N(CH3)CH2-. In some embodiments, r is 1 and B is R B1 and R B2 Together with it, it forms the -CH2CH=CHCH2-, -CH2CH2CH2CH2-, -CH2CH(OH)CH(OH)CH2-, or -CH2CH2N(CH3)CH2CH2- group. In some embodiments, r is 1 and B is R B1 and R B2 Together with it, it forms -CH2CH=CHCH2-.

[0172] In some embodiments of the compounds disclosed herein, when s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with D, they form a linking group, where D is -halo(C 1~12 Alkyl)-, may be substituted-C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-, Here, the substitution may be made -C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(-C) 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)C 1~6 The alkyl part of alkyl- is a halogen, halo(C) 1~4 Alkyl), -OH, -OR c -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c CONH2, -CONR c R d , -SO2NH 2 -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2Rc , and -NR d SO2R c They may be substituted with one or two substituents that are selected more independently, and such substitution may occur -C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, aminos, or (C) 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 The molecule may be substituted with 1 to 4 substituents, each independently substituted with an alkoxy- group.

[0173] In some embodiments of the compounds disclosed herein, when s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with D, they form a linking group, where D is -halo(C 1~12 Alkyl)-, may be substituted-C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-, Here, the substitution may be made -C 1~12 Alkyl-, or possibly substituted-C 2~12 Alkenyl-, may be substituted-C 2~12 Alkinyl-, may be substituted-C 1~6 Alkyl-OC 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-NR a -C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 The alkyl part of alkyl- is a halogen, halo(C) 1~4 Alkyl), -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -ORc -NH2, -NR c R d , -OCOR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , and -NR d SO2R c They may be substituted with one or two substituents that are selected more independently, and such substitution may occur -C 1~6 Alkyl-(C 3~6 Cycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-phenyl-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(4-6 member heterocycloalkyl)-C 1~6 Alkyl-, or possibly substituted-C 1~6 Alkyl-(5-6 member heteroaryl)-C 1~6 Alkyl-C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, or 5-6 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, and C 1~4 Alkoxy-(C) 1~4 The molecule may be substituted with 1 to 4 substituents, each independently substituted with an alkoxy- group.

[0174] In some embodiments of the compounds disclosed herein, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is R C1 and R C2 Together with these, they form a 4-8 membered linking group. In a further embodiment, s is 1, W1 and Z2 are independently C or N, and D is R C1 and R C2 Together with it, it forms a 4-6 membered linking group. In a further embodiment, s is 1 and D is R C1 and R C2 Together with it, it forms a five-membered linking group.

[0175] In some embodiments, when s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is a substituted -C 2~10 Alkyl group or unsubstituted C 2~10 Alkyl-, -C 2~10 Alkenyl-, -C 2~10 Alkinyl-, -C 1~4 Alkyl-OC 1~4 Alkyl-, or -C 1~4 Alkyl-NR a -C 1~4 It is an alkyl group, where the substituted -C 2~10 The alkyl group is a halogen, hydroxy, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with 1 to 4 substituents independently selected from the alkoxy group.

[0176] In some embodiments, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is a substituted -C 2~10 Alkyl group or unsubstituted C 2~10 Alkyl-, -C 2~10 Alkenyl-, -C 2~10 Alkinyl-, -C 1~4 Alkyl-OC 1~4 Alkyl-, or -C 1~4 Alkyl-NR a -C 1~4 It is an alkyl group, where the substituted -C 2~10 The alkyl group is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with 1 to 4 substituents independently selected from the alkoxy group.

[0177] In some embodiments, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is a substituted -C 2~8 Alkyl group or unsubstituted C 2~8 Alkyl-, -C 2~8 Alkenyl-, -C 2~8 Alkinyl-, -C 1~2 Alkyl-OC1~2 Alkyl-, or -C 1~2 Alkyl-NR a -C 1~2 It is an alkyl group, where the substituted -C 2~8 The alkyl group is a halogen, hydroxy, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0178] In some embodiments, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is a substituted -C 2~8 Alkyl group or unsubstituted C 2~8 Alkyl-, -C 2~8 Alkenyl-, -C 2~8 Alkinyl-, -C 1~2 Alkyl-OC 1~2 Alkyl-, or -C 1~2 Alkyl-NR a -C 1~2 It is an alkyl group, where the substituted -C 2~8 The alkyl group is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0179] In some embodiments, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is a substituted -C 2~6 Alkyl group or unsubstituted C 2~6 Alkyl-, -C 2~6 Alkenyl-, -C 2~6 Alkinyl-, -C 1~2 Alkyl-OC 1~2 Alkyl-, or -C 1~2 Alkyl-NR a -C 1~2 It is an alkyl group, where the substituted -C 2~6 The alkyl group is a halogen, hydroxy, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0180] In some embodiments, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is a substituted -C 2~6 Alkyl group or unsubstituted C 2~6 Alkyl-, -C 2~6 Alkenyl-, -C 2~6 Alkinyl-, C 1~2 Alkyl-OC 1~2 Alkyl-, or -C 1~2 Alkyl-NR a -C 1~2 It is an alkyl group, where the substituted -C 2~6 The alkyl group is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, Halo(C 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, and C 1~4 Each molecule is substituted with one or two substituents independently selected from the alkoxy group.

[0181] In some embodiments, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is -C 2~4 Alkyl group, -C 2~4 Alkenyl group, or -C 2~4 It is an alkynyl group.

[0182] In some embodiments, s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of these is independently -CH2-, and D is -CH2CH2CH2-, where D is R C1 and R C2 Together with it, it forms a -CH2CH2CH2CH2CH2- group.

[0183] In some embodiments, R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH2N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH2N(R d )CO(R f )

[0184] In some embodiments, R 3 and R 5 One of them is -CON(R d )(R f ), -CH2N(R d)(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H, COOH, or -CO2R c That is the case.

[0185] In some embodiments, R 3 and R 5 Each of them is independent of -CON(R d )(R f ) and R 3 and R 5 One of them is -CON(R d )(R f ) and R 3 and R 5 The other of these is H, COOH, or -CO2R C In some embodiments, R 3 and R 5 Each of them is independent of -CON(R d )(R f ) and R 3 and R 5 One of them is -CON(R d )(R f ) and R 3 and R 5 The other of these is H or -CO2R C In some embodiments, R 3 and R 5 Each of them is independent of -CON(R d )(R f ) In some embodiments, R 3 and R 5 One of them is -CON(R d )(R f ) and R 3 and R 5 The other of these is H. In some embodiments, R 3 and R 5 One of them is -CON(R d )(Rf ) and R 3 and R 5 Of these, the other is -CO2R C In some embodiments, R 3 and R 5 One of them is -CON(R d )(R f ) and R 3 and R 5 The other of these is -CON(R d )(R f )

[0186] In some embodiments, R 3 and R 5 Each of them independently performs -CH2N(R d )(R f ) and R 3 and R 5 One of them is -CH2N(R d )(R f ) and R 3 and R 5 The other of these is H, COOH, or -CO2R C In some embodiments, R 3 and R 5 Each of them independently performs -CH2N(R d )(R f ) and R 3 and R 5 One of them is -CH2N(R d )(R f ) and R 3 and R 5 The other of these is H or -CO2R C In some embodiments, R 3 and R 5 Each of them independently performs -CH2N(R d )(R f ) In some embodiments, R 3 and R 5 One of them is -CH2N(R d )(R f ) and R 3 and R 5 The other of these is H. In some embodiments, R 3 and R5 One of them is -CH2N(R d )(R f ) and R 3 and R 5 The other of these is -CO2(R C ) In some embodiments, R 3 and R 5 One of them is -CH2N(R d )(R f ) and R 3 and R 5 The other of these is -CON(R d )(R f )

[0187] In some embodiments, R 3 and R 5 Each of them independently corresponds to -N(R d )(R f ) and R 3 and R 5 One of them is -N(R d )(R f ) and R 3 and R 5 The other of these is H, COOH, or -CO2(R C ) In some embodiments, R 3 and R 5 Each of them independently corresponds to -N(R d )(R f ) and R 3 and R 5 One of them is -N(R d )(R f ) and R 3 and R 5 The other of these is H or -CO2R C In some embodiments, R 3 and R 5 Each of them independently corresponds to -N(R d )(R f ) In some embodiments, R 3 and R 5 One of them is -N(R d )(R f ) and R 3 and R 5The other of these is H. In some embodiments, R 3 and R 5 One of them is -N(R d )(R f ) and R 3 and R 5 Of these, the other is -CO2R C In some embodiments, R 3 and R 5 One of them is -N(R d )(R f ) and R 3 and R 5 The other of these is -CON(R d )(R f )

[0188] In some embodiments, R 3 and R 5 Each of them independently corresponds to -N(R d )CO(R f ) and R 3 and R 5 One of them is -N(R d )CO(R f ) and R 3 and R 5 The other of these is H, COOH, -CO2R C , or -CON(R d )(R f ) In some embodiments, R 3 and R 5 Each of them independently corresponds to -N(R d )CO(R f ) and R 3 and R 5 One of them is -N(R d )CO(R f ) and R 3 and R 5 The other of these is H or -CO2R C In some embodiments, R 3 and R 5 Each of them independently corresponds to -N(R d )CO(R f ) In some embodiments, R 3 and R 5 One of them is -N(Rd )CO(R f ) and R 3 and R 5 The other of these is H. In some embodiments, R 3 and R 5 One of them is -N(R d )CO(R f ) and R 3 and R 5 Of these, the other is -CO2R C In some embodiments, R 3 and R 5 One of them is -N(R d )CO(R f ) and R 3 and R 5 The other of these is -CON(R d )(R f )

[0189] In some embodiments, R 3 and R 5 Each of them independently performs -CH2N(R d )CO(R f ) and R 3 and R 5 One of them is -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H, COOH, -CO2R C , or -CON(R d )(R f ) In some embodiments, R 3 and R 5 Each of them independently performs -CH2N(R d )CO(R f ) and R 3 and R 5 One of them is -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H or -CO2R C In some embodiments, R 3 and R 5 Each of them independently performs -CH2N(Rd )CO(R f ) In some embodiments, R 3 and R 5 One of them is -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is H. In some embodiments, R 3 and R 5 One of them is -CH2N(R d )CO(R f ) and R 3 and R 5 Of these, the other is -CO2R C In some embodiments, R 3 and R 5 One of them is -CH2N(R d )CO(R f ) and R 3 and R 5 The other of these is -CON(R d )(R f )

[0190] In some embodiments, R 3 and R 5 These are both -CONH2.

[0191] In some embodiments, R 3 and R 5 One of them is -CH2NH2, and R 3 and R 5 The other of these is -CONH2. In some embodiments, R 3 and R 5 One of them is -CONH2, and R 3 and R 5 The other of these is -COOCH3. In some embodiments, R 3 and R 5 One of them is -CH2N(CH3)2, R 3 and R 5 The other of these is -CONH2. In some embodiments, R 3 and R 5 One of them is -CH2NHC(O)CH3, R3 and R 5 The other of these is -CONH2. In some embodiments, R 3 and R 5 One of them is -NHC(O)CH3, R 3 and R 5 The other of these is -CONH2. In some embodiments, R 3 and R 5 One of them is -NH2, R 3 and R 5 The other of these is -CONH2.

[0192] In some embodiments, R 4 and R 6 These are H, halogen, and halo C, respectively, and are independent of each other. 1~4 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -NH2, -NR C R C , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g )SO2(C 1~2 Alkyl)-N(R h )(R f ), -N(R g )CO2(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~4 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6Alkyl)amino-, and optionally substituted-(C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OR c -NH2, -NR C R C , -NR c R d -CO2H, -CO2R c , -OCOR c , -CO2R d -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-, Halo(C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, C 1~4 Alkoxy-C 1~4 Alkoxy)-, -COR d , -CON(R d )(Rf ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0193] In some embodiments, R 4 and R 6 These are H, halogen, and halo (C) respectively, independently. 1~4 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -NH2, -NR C R C , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g )SO2(C 1~2 Alkyl)-N(R h )(R, -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 2~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted-C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH)2, -OP(O)(R I R II)2, -OR c -NH2, -NR C R C , -NR c R d -CO2H, -CO2R c OCOR c , -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I RII )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0194] In some embodiments, R 4 and R 6 These are H.

[0195] In some embodiments, R 4 and R 6 These are halogen and halo (C) respectively, independently. 1~4 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -NH2, -NR C R C , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g )SO2(C 1~2 Alkyl)-N(R h )(R, -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 2~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C1~6 Alkyl)oxy-, may be substituted-C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR C R C , -NR c R d -CO2H, -CO2R c OCOR c , -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0196] In some embodiments, R 4 H is H.

[0197] In some embodiments, R 4 is halogen, halo (C 1~4 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -NH2, -NR C R C , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g )SO2(C 1~2 Alkyl)-N(R h )(R, -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 2~6Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted-C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR C R C , -NR c R d -CO2H, -CO2R c OCOR c , -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R c The group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0198] In some embodiments, R 6 H is H.

[0199] In some embodiments, R 6 is halogen, halo (C 1~4 Alkyl), Halo (C 1~6 Alkoxy)-, Hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -NH2, -NR C R C , -NR c R d , -COR c , -CO2R c , -N(R d )COR c , -N(R d )SO2R c , -N(R g )SO2(C 1~2 Alkyl)-N(Rh )(R, -N(R g )CO(C 1~2 Alkyl)-N(R h )(R f ), may be replaced (C 1~6 Alkyl), may be substituted (C 2~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), may be substituted (C 1~6 Alkyl)oxy-, may be substituted-C 1~6 Alkyl)amino-, and possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is -OH, -OP(O)(OH)2, -OP(O)(R I R II )2, -OR c -NH2, -NR C R C , -NR c R d -CO2H, -CO2R c OCOR c , -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d -OCONH2, -OCONR c R d , -NR d COR c , -NR d SOR c , -NR d CO2R c , -NR d SO2R cThe group may be substituted with 1 to 4 substituents independently selected from optionally substituted phenyl, optionally substituted 5-6 member heterocycloalkyl, and optionally substituted 5-6 member heteroaryl groups, where the optionally substituted phenyl, 5-6 member heterocycloalkyl, or 5-6 member heteroaryl may be halogen, hydroxyl, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0200] In some embodiments, R 14 C may be absent, or may be replaced by H, a halogen, or other C atoms. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c Rd , and -OCONR c R d They may be substituted with more selective substituents.

[0201] In some embodiments, R 14 It does not exist.

[0202] In some embodiments, R 14 is H, halogen, or possibly substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0203] In some embodiments, R 14 H is H.

[0204] In some embodiments, R 14 C may be a halogen or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0205] In some embodiments, R 14 It is a halogen.

[0206] In some embodiments, R 14 C may be substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0207] In some embodiments, R 14 C may be substituted. 1~4 Alkyl, where the substituted C 1~4 The alkyl group may be substituted with a halogen.

[0208] In some embodiments, R 14 C may be substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0209] In some embodiments, R 14 is a substituted C 1~4 It is alkyl, and here the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR cR d , and -OCONR c R d It is substituted with a more selective substituent.

[0210] In some embodiments, R 14 is C 1~4 It is alkyl. In some embodiments, R 14 is methyl or ethyl. In some embodiments, R 14 is methyl. In some embodiments, R 14 is ethyl. In some embodiments, R 14 is a substituted C 1~4 It is alkyl, and here the substituted C 1~4 The alkyl group is substituted with a halogen.

[0211] In some embodiments, R 14 is a substituted C 1~4 It is alkyl, and here the substituted C 1~4 Alkyl is -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It is substituted with a more selective substituent.

[0212] In some embodiments, R 14 It is -CH2COOH.

[0213] In some embodiments, R 16 is either H or does not exist. In some embodiments, R 16 is H. In some embodiments, R 16 It does not exist.

[0214] In some embodiments, R 16 is H, halogen, or C 1~4 It is alkyl. In some embodiments, R 16It is a halogen.

[0215] In some embodiments, R 16 is C 1~4 It is alkyl. In some embodiments, R 16 is methyl or ethyl. In some embodiments, R 16 is methyl. In some embodiments, R 16 It is ethyl.

[0216] In some embodiments, R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These, together with one or more atoms connecting them, form a 5-6 membered ring; or, R 16 and R 17 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0217] In some embodiments, R 15 and R 17 Each of these is independently either absent, H, cyclopropyl, halogen, or optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c Rd -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0218] In some embodiments, R 15 and R 17 They do not exist independently of each other.

[0219] In some embodiments, R 15 and R 17 Each of these is independently H, cyclopropyl, halogen, or an optionally substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0220] In some embodiments, R 15 and R 17 Each of these is independently H.

[0221] In some embodiments, R 15 and R 17 Each is independently a Halloween (C 1~4 It is alkyl.

[0222] In some embodiments, R 15 and R17 Each of these is independently cyclopropyl, halogenated, or possibly substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 15 and R 19 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0223] In some embodiments, R 15 and R 17 Each of these is independently cyclopropyl, halogenated, or possibly substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0224] In some embodiments, R 15 and R 19 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0225] In some embodiments, R 16 and R 17 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0226] In some embodiments, R 15 and R 17 Each of these is either absent, or H, cyclopropyl, or C, independently of the others. 1~4 It is alkyl.

[0227] In some embodiments, R 15 and R 17 Each of these is methyl.

[0228] In some embodiments, R 15 C is either absent, or may be substituted with H, cyclopropyl, halogen, or C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0229] In some embodiments, R 15 It does not exist.

[0230] In some embodiments, R 15 is H, cyclopropyl, halogen, or possibly substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0231] In some embodiments, R 15 H is H.

[0232] In some embodiments, R 15 Haha (C 1~4 It is alkyl.

[0233] In some embodiments, R 15 C is cyclopropyl, halogen, or may be substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0234] In some embodiments, R 15 It is either absent, or H, cyclopropyl, or C 1~4 It is alkyl. In some embodiments, R 15 is cyclopropyl or C 1~4 It is alkyl. In some embodiments, R 15 It is either absent, or H, cyclopropyl, or C 1~4 It is alkyl. In some embodiments, R 15 is cyclopropyl. In some embodiments, R 15 It is either absent, or H, cyclopropyl, or C 1~4 It is alkyl. In some embodiments, R 15 is C 1~4 It is alkyl.

[0235] In some embodiments, R 15 Each of these is methyl.

[0236] In some embodiments, R17 C is either absent, or may be substituted with H, cyclopropyl, halogen, or C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0237] In some embodiments, R 17 It does not exist.

[0238] In some embodiments, R 17 is H, cyclopropyl, halogen, or possibly substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0239] In some embodiments, R 17 H is H.

[0240] In some embodiments, R 17 Haha (C 1~4 It is alkyl.

[0241] In some embodiments, R 17 C is cyclopropyl, halogen, or may be substituted. 1~4Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0242] In some embodiments, R 17 It is either absent, or H, cyclopropyl, or C 1~4 It is alkyl. In some embodiments, R 17 is cyclopropyl or C 1~4 It is alkyl. In some embodiments, R 17 It is either absent, or H, cyclopropyl, or C 1~4 It is alkyl. In some embodiments, R 17 is cyclopropyl. In some embodiments, R 17 It is either absent, or H, cyclopropyl, or C 1~4 It is alkyl. In some embodiments, R 17 is C 1~4 It is alkyl.

[0243] In some embodiments, R 17 Each of these is methyl.

[0244] In some embodiments, R 18 and R 19 Each of these is independent of the C that may be absent, H, a halogen, or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c Rd , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 17 and R 18 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0245] In some embodiments, R 18 and R 19 They do not exist independently of each other.

[0246] In some embodiments, R 18 and R 19 Each of these can be independently H, a halogen, or a substituted C. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 17 and R 18 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0247] In some embodiments, R 18 and R 19 Each of these is independently H.

[0248] In some embodiments, R 18 and R 19 Each of these C atoms may be a halogen or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2Rc ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; or, R 17 and R 18 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0249] In some embodiments, R 18 and R 19 Each of these C atoms may be a halogen or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d -CH2-CO2R c , and -OCONR c R d They may be substituted with more selective substituents.

[0250] In some embodiments, R 17 and R 18 These atoms, together with one or more atoms connecting them, form a 5-6 membered ring.

[0251] In some embodiments, R 18 C may be absent, or may be replaced by H, a halogen, or other C atoms. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d, and -OCONR c R d They may be substituted with more selective substituents.

[0252] In some embodiments, R 18 It does not exist.

[0253] In some embodiments, R 18 is H, halogen, or possibly substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0254] In some embodiments, R 18 H is H.

[0255] In some embodiments, R 18 Haha (C 1~4 It is alkyl.

[0256] In some embodiments, R 18 C may be a halogen or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d , and -SO2NR c R d They may be substituted with more selective substituents.

[0257] In some embodiments, R 18C may be a halogen or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0258] In some embodiments, R 19 C may be absent, or may be replaced by H, a halogen, or other C atoms. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0259] In some embodiments, R 19 It does not exist.

[0260] In some embodiments, R 19 is H, halogen, or possibly substituted C 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c Rd They may be substituted with more selective substituents.

[0261] In some embodiments, R 19 H is H.

[0262] In some embodiments, R 19 Haha (C 1~4 It is alkyl.

[0263] In some embodiments, R 19 C may be a halogen or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d , and -SO2NR c R d They may be substituted with more selective substituents.

[0264] In some embodiments, R 19 C may be a halogen or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0265] In some embodiments, R 15 , R 17 , R 18 , or R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl, and here C 1~4Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0266] In some embodiments, R 15 , R 17 , R 18 , or R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from halogens.

[0267] In some embodiments, R 15 , R 17 , R 18 , or R 19 Each of these is independently -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d That is the case.

[0268] In some embodiments, R 15 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R dThey may be substituted with more selective substituents.

[0269] In some embodiments, R 15 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from halogens.

[0270] In some embodiments, R 15 は-OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d That is the case.

[0271] In some embodiments, R 17 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0272] In some embodiments, R 17 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from halogens.

[0273] In some embodiments, R 17 は-OR c , -NR c R d , -CO2Rc ,-CONR c R d -SO2NR c R d , and -OCONR c R d That is the case.

[0274] In some embodiments, R 18 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0275] In some embodiments, R 18 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from halogens.

[0276] In some embodiments, R 18 は-OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d That is the case.

[0277] In some embodiments, R 19 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d, -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0278] In some embodiments, R 19 It does not exist, or it is H or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from halogens.

[0279] In some embodiments, R 19 は-OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d That is the case.

[0280] In some embodiments, when Z1, Y1, and Y2 are each independently C or N, R 14 , R 18 , and R 19 Each of these C elements may be independent, nonexistent, or substituted. 1~4 Alkyl, where the substituted C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R C ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0281] In some embodiments, R14 , R 15 , R 16 , R 17 , R 18 , and R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl.

[0282] In some embodiments, R 14 , R 15 , R 16 , R 17 , R 18 , and R 19 Each is independently C 1~4 It is alkyl.

[0283] In some embodiments, R 14 , R 15 , R 16 , R 17 , R 18 , and R 19 Each is independently C 1~3 It is alkyl (i.e., methyl or ethyl).

[0284] In some embodiments, R 14 It is ethyl.

[0285] In some embodiments, R 14 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more selected substituent. In some embodiments, R 14 It does not exist or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from halogens.

[0286] In some embodiments, R 14 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0287] In some embodiments, R 14 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is -OR c and -NR c R d They may be substituted with more selective substituents.

[0288] In some embodiments, R 14 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0289] In some embodiments, R 14 It does not exist or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from -CO2H.

[0290] In some embodiments, R 14 It does not exist, or C 1~4It is alkyl or -CH2-CO2H.

[0291] In some embodiments, R C2 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0292] In some embodiments, R C2 It does not exist or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from halogens.

[0293] In some embodiments, R C2 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0294] In some embodiments, R C2 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is -OR c and -NR c R d They may be substituted with more selective substituents.

[0295] In some embodiments, R C2 It does not exist or C 1~4 It is alkyl, and here C 1~4 Alkyl is -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d They may be substituted with more selective substituents.

[0296] In some embodiments, R C2 It does not exist or C 1~4 It is alkyl, and here C 1~4 The alkyl group may be substituted with a substituent selected from -CO2H.

[0297] In some embodiments, R C2 It does not exist, or C 1~4 It is alkyl or -CH2-CO2H.

[0298] In some embodiments, R 19 It is methyl.

[0299] In some embodiments, R 16 It is ethyl.

[0300] In some embodiments, R 18 It is methyl.

[0301] In some embodiments, R a H, -R c , -COR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d , or -CH2CO2R c That is the case.

[0302] In some embodiments, R a H, C 1~4 Alkyl, -CO(C 1~4 Alkyl), -CO(C 1~4 Alkyl)-OH,-CO(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -CO(C 1~4 Alkyl)-NH2,-CO(C 1~4 Alkyl)-NH(C 1~4 Alkyl), or -CO(C 1~4 Alkyl)-N(C 1~4 Alkyl)(C 1~4 It is alkyl.

[0303] In some embodiments, R a H is H.

[0304] In some embodiments, R a ha-R c , -COR c -CO2H, -CO2R c -SOR c , -SO2R c -CONH2, -CONR c R d -SO2NH2, -SO2NR c R d , or -CH2-CO2R c That is the case.

[0305] In some embodiments, R a ha-R c In some embodiments, R a ha-COR c In some embodiments, R a is -CO2H. In some embodiments, R a -CO2R c In some embodiments, R a is -SOR c In some embodiments, R a ha-SO2R c In some embodiments, R ais -CONH2. In some embodiments, R a -CONR c R d In some embodiments, R a is -SO2NH2. In some embodiments, R a -SO2NR c R d That is the case.

[0306] In some embodiments, R a -CH2-CO2R c In some embodiments, R a It is -CH2-CO2H.

[0307] In some embodiments, each R b C is independent 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), or -(C 1~4 Alkyl)-CO-O-(C 1~4 It is alkyl.

[0308] In some embodiments, each R b C is independent 1~4 It is alkyl.

[0309] In some embodiments, each R b It is independently called Halo (C 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), or -(C 1~4 Alkyl)-CO-O-(C 1~4 It is alkyl.

[0310] In some embodiments, each R c H and C are independent of each other. 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), -(C 1~4 Alkyl)-CO-O-(C 1~4 C (alkyl), may be substituted. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4It is an alkyl-9~10 member heteroaryl, Here, the C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 Alkyl-9~10 member heteroaryl C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, 5-6 member heteroaryl moiety, or 9-10 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0311] In some embodiments, each R c H is independent of each other.

[0312] In some embodiments, each R c C is independent 1~4 Alkyl, Halo(C) 1~4 Alkyl), -(C 1~4 alkyl)-OH, -(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, -(C 1~4 Alkyl)-O-(C 1~4 Alkyl), -(C 1~4 Alkyl)-N(R e )(R f ), -(C 1~4 Alkyl)-O-CO(C 1~4 Alkyl), -(C 1~4 Alkyl)-CO-O-(C 1~4 C (alkyl), may be substituted. 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C 1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 It is an alkyl-9~10 member heteroaryl, Here, the C which may be substituted 3~6 Cycloalkyl, optionally substituted phenyl, optionally substituted 4-6 member heterocycloalkyl, optionally substituted 5-6 member heteroaryl, optionally substituted 9-10 member heteroaryl, optionally substituted -C 1~4 Alkyl-C 3~6 Cycloalkyl, may be substituted-C1~4 Alkylphenyl, possibly substituted with C 1~4 Alkyl-4 to 6-membered heterocycloalkyl, possibly substituted-C 1~4 Alkyl-5 to 6-membered heteroaryl, or possibly substituted-C 1~4 Alkyl-9~10 member heteroaryl C 3~6 The cycloalkyl moiety, phenyl moiety, 4-6 member heterocycloalkyl moiety, 5-6 member heteroaryl moiety, or 9-10 member heteroaryl moiety may contain halogens, hydroxyls, -OP(O)(OH)2, or -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0313] In some embodiments, each R d These are independently H, hydroxyl, or C 1~4 It is alkyl. In some embodiments, each R d H or C 1~4 It is alkyl. In some embodiments, each R d R is independently H or hydroxyl. In some embodiments, each R d These are independently hydroxyl or C 1~4It is alkyl. In some embodiments, each R d H is independent of each other. In some embodiments, each R d C is independent 1~4 It is alkyl. In some embodiments, each R d It is independently hydroxyl.

[0314] In some embodiments, each R e H and (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -CO2(C 1~4 Alkyl), -(C 1~4 Alkyl)amino, -(C 1~4 Alkyl)-C 1~4 Alkoxy, -CO- (may be substituted 5-6 member heterocycloalkyl), -CO- (C 1~4 Alkyl)-(optionally substituted 5-6 member heterocycloalkyl), -CO-(optionally substituted 5-6 member heteroaryl), -CO-(C 1~4 Alkyl)-(may be substituted 5-6 member heteroaryl), Here, the optionally substituted 5-6 member heterocycloalkyl or optionally substituted 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)OP(O)(OH)2, -(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4 Alkoxy-(C) 1~4 Alkoxy)-, -CORd , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0315] In some embodiments, each R e H is independent of each other.

[0316] In some embodiments, each R e (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -CO2(C 1~4 Alkyl), -(C 1~4 Alkyl)amino, -(C 1~4 Alkyl)-C 1~4 Alkoxy, -CO- (may be substituted 5-6 member heterocycloalkyl), -CO- (C 1~4 Alkyl)-(optionally substituted 5-6 member heterocycloalkyl), -CO-(optionally substituted 5-6 member heteroaryl), -CO-(C 1~4 Alkyl)-(may be substituted 5-6 member heteroaryl), Here, the optionally substituted 5-6 member heterocycloalkyl or optionally substituted 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~4 Alkyl)amino-, (C 1~4 Alkyl)(C 1~4 Alkyl)amino-, C 1~4 Alkyl, Halo(C) 1~4 Alkyl), Halo (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)OP(O)(OH)2, -(C 2~4 Alkoxy)-OP(O)(R I R II )2, C 1~4Alkoxy-(C) 1~4 Alkoxy)-, -COR d , -CON(R d )(R f ), and -CO2R d They may be substituted with 1 to 4 substituents, each selected independently.

[0317] In some embodiments, each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) In some embodiments, each R f H or (C 1~4 Alkyl) In some embodiments, each R f R is independently H or hydroxyl. In some embodiments, each R f These are independently hydroxyl or (C 1~4 Alkyl) In some embodiments, each R f H is independent of each other. In some embodiments, each R f (C 1~4 Alkyl) In some embodiments, each R f It is independently hydroxyl.

[0318] In some embodiments, R I and R II Each of them is independent of (C 1~6 It is alkyl)oxy-. In some embodiments, each R I (C 1~6 It is alkyl)oxy-. In some embodiments, each R II (C 1~6 It is alkyl(oxy).

[0319] In some embodiments, X5 is N.

[0320] In some aspects, X5 is CR A2 And here R A2 H, halogen, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -N(R e )(Rf ) will be selected from.

[0321] In some aspects, X5 is CR A2 And here R A2 These are halogens, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -N(R e )(R f ) will be selected from.

[0322] In some aspects, X5 is CR A2 And here R A2 -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -N(R e )(R f ) will be selected from.

[0323] In some aspects, X5 is CR A2 And here R A2 The element is selected from H, halogen, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NH2.

[0324] In some aspects, X5 is CR A2 And here R A2 The halogen is selected from halogen, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NH2.

[0325] In some aspects, X5 is CR A2 And here R A2 The molecule is selected from -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NH2.

[0326] In some embodiments, X6 is N.

[0327] In some aspects, X6 is CR A1And here R A1 H, halogen, hydroxyl, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -N(R e )(R f ) will be selected from.

[0328] In some aspects, X6 is CR A1 And here R A1 These include halogens, hydroxyls, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -N(R e )(R f ) will be selected from.

[0329] In some aspects, X6 is CR A1 And here R A1 These are hydroxy, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -N(R e )(R f ) will be selected from.

[0330] In some aspects, X6 is CR A1 And here R A1 -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -N(R e )(R f ) will be selected from.

[0331] In some aspects, X6 is CR A1 And here R A1 The group is selected from H, halogen, hydroxyl, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NH2.

[0332] In some aspects, X6 is CR A1 And here R A1The group is selected from halogen, hydroxyl, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NH2.

[0333] In some aspects, X6 is CR A1 And here R A1 The group is selected from hydroxyl, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NH2.

[0334] In some aspects, X6 is CR A1 And here R A1 The molecule is selected from -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NH2.

[0335] In some embodiments, X5 is N and X6 is N.

[0336] In some aspects, X5 is CR A2 X6 is CR A1 In some embodiments, X5 is CR A2 And X6 is N. In some embodiments, X5 is N and X6 is CR A1 That is the case.

[0337] In some aspects, X5 is CR A2 X6 is CR A1 And here R A1 is -OCH3, and R A2 It is -OCH2CH2CH2OH.

[0338] In some aspects, X5 is CR A2 X6 is CR A1 And here R A1 H is R A2 It is -OCH2CH2CH2OH.

[0339] In some aspects, X5 is CR A2X6 is CR A1 And here R A1 is -OH, and R A2 It is -OCH2CH2CH2OH.

[0340] In some aspects, X5 is CR A2 X6 is CR A1 And here R A1 is -OCH3, and R A2 It is -OCH2CH2CH2COOH.

[0341] In some aspects, X5 is CR A2 X6 is CR A1 And here R A1 is -OH, and R A2 It is -OCH2CH2CH2COOH.

[0342] In some aspects, X5 is CR A2 X6 is CR A1 And here R A1 is -OCH3, and R A2 It is -OCH2CH2CH2NH2.

[0343] In some aspects, X5 is CR A2 X6 is CR A1 And here R A1 is -OH, and R A2 It is -OCH2CH2CH2NH2.

[0344] In some embodiments, X6 is N and X5 is CR A1 And here R A1 It is -OCH2CH2CH2OH.

[0345] In some embodiments, X6 is N and X5 is CR A1 And here R A1 It is -OCH2CH2CH2COOH.

[0346] In some embodiments, X6 is N and X5 is CR A1And here R A1 It is -OCH2CH2CH2NH2.

[0347] In some embodiments, X6 is N and X5 is CR A1 And here R A1 It is a halogen.

[0348] In some embodiments, X6 is N and X5 is CR A1 And here R A1 It is -OCH3.

[0349] In some embodiments, X6 is N and X5 is CR A1 And here R A1 It is -OH.

[0350] In some aspects, X5 is CR A2 X6 is CR A1 And here R A1 is -OCH2CH2CH2NH2, and R A2 It is -OCH2CH2CH2NH2.

[0351] In some embodiments, R A1 and R A2 These are independently H, halogen, hydroxyl, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, or -N(R e )(R f )

[0352] In some embodiments, X3 and X4 are independently S or NR f And here R f H is H.

[0353] In some embodiments, X3 is S and X4 is NR f And here R f H is H.

[0354] In some embodiments, X9 is N or CR 4In some embodiments, X9 is N. In some embodiments, X9 is CR. 4 In some embodiments, X9 is CH.

[0355] In some embodiments, this disclosure relates to compounds of formula (I'), formula (IA'), formula (II'), formula (III'), formula (IV'), or formula (V'), or their prodrugs, solvates, pharmaceutically acceptable salts, or tautomers, wherein, The sum of r and s is 1 or 2; X3 and X4 are independently S or NR f and; X5 is N or CR A2 X6 is N or CR A1 X9 is N or CH; R A1 and R A2 These are independently H, halogen, hydroxyl, -OCH2CH2CH2OH, -OCH2CH2CH2COOH, -OCH2CH2CH2NH2, -OCH3, and -NR e R f More selected; r is 0, R B1 and R B2 These are H, respectively; or, r is 1, R B1 and R B2 Each of these is independently -CH2-, and B is -CH=CH-, -CH2CH2-, -CH(OH)CH(OH)-, or -CH2N(CH3)CH2-; s is 0, and Y1, Y2, Z1, and Z2 are each independently either O or S; s is 0, W1 is C, R C1 It is methyl; s is 0, Z2 is C, R C2 is ethyl; s is 0, W1 is N, R C1 It does not exist; s is 0, Z2 is N, and R C2 It is either absent or ethyl; s is 1, W1 and Z2 are independently C or N, and R C1 and R C2 Each of them is independently -CH2-, and D is -CH2CH2CH2-; R 3 and R 5 These are independently -CONH2, -CH2NH2, -NH2, -CH2N(CH3)2, -CH2NHC(O)CH3, or -NHC(O)CH3; R 4 and R 6 Each of these is H; R 14 It is either absent, methyl, or ethyl; R 15 is either absent, H, or methyl; R 16 is either absent, or H, methyl, or ethyl; and R 17 It is either absent or methyl.

[0356] In some embodiments, the compound is a compound of formula (I-B'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000046.tif63128In formula, Y1, Y2, Z1, and Z2 are each independently O, S, C, or N; X1, X2, W1, and W2 are each independently either C or N; X3, X4, X5, X6, X9, R 3 , R 5 , R d , and R f Each of these is independent, as defined in equation (IA'); R c is C 1~4 It is alkyl; R B1 and R B2 Each of them is independently -CH2-; B is - Haro(C 1~5 Alkyl), unsubstituted-C1~5 Alkyl or unsubstituted -C 2~5 Alkenil- and; R A2 and R A1 These are independently H, halogen, hydroxyl, amino, and amino(C) 1~4 Alkyl)-, -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 membered heteroaryls; where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -O-PO)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -(C 1~6 Alkyl)-NH2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -(C 1~4 Alkyl)-NH2,-(C 1~4 Alkyl)-C 1~4 Alkoxy, and -CO2(C 1~4 Selected from alkyl groups; R 4 and R 6 is H; R 14 and R C2 Each is independent, either non-existent or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may also be substituted with a more preferred substituent; R 16 and R C1 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl; and R 15 , R 17 , R 18 , or R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl, and here C 1~4Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; and Each R I and R II (C 1~6 It is alkyl)oxy-; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by1~4 It is alkyl, and here R c is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0357] In some embodiments, the compound is a compound of formula (I-B'), where X9 is CR. 4 That is the case.

[0358] In some embodiments, the compound is the compound of formula (II-B'), or its prodrug, solvate, pharmaceutically acceptable salt, or tautomer: TIFF0007843695000047.tif75128In formula, Y2 and Z2 are independently O, S, C, or N; X2 and W2 are independently either C or N; X3, X4, X5, X6, X9, R 3 , R 5 , R d , and R f Each of these is independent, as defined in equation (IA'); R c is C1~4 It is alkyl; R B1 and R B2 Each of them is independently -CH2-; B is - Haro(C 1~5 Alkyl), unsubstituted-C 1~5 Alkyl or unsubstituted -C 1~5 Alkenil- and; R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 membered heteroaryls; where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -(C 1~6 Alkyl)-NH2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -(C 1~4 Alkyl)-NH2,-(C 1~4 Alkyl)-C 1~4 Alkoxy, and -CO2(C 1~4 Selected from alkyl groups; R 4 and R 6 is H; R C2 It does not exist, or C 1~4 It is alkyl or -CH2COOH; R 16 and R C1 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl; and R 17 , R 18 , or R 19 Each is independent, either does not exist, or H, C 1~4 Alkyl, or halo(C) 1~4 Alkyl) and Each R I and R II (C 1~6 It is alkyl(oxy).

[0359] In some embodiments, the compound is a compound of formula (II-B'), where X9 is CR. 4 In some embodiments, the compound is a compound of formula (I-B'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, wherein, R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 membered heteroaryls; where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -(C 1~6 Alkyl)-NH2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here Rc is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0360] In some embodiments, the compound is a compound of formula (I-B'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, wherein, R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxyl, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 membered heteroaryls; where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-, Halo(C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 The alkoxy(-) group may be substituted with 1 to 4 substituents independently selected from each of them; and R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), and -CO2(C 1~4 Selected from alkyl groups; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(RI R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0361] In some embodiments, the compound is a compound of formula (I-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000048.tif62128In formula, Y1, Y2, Z1, and Z2 are each independently O, S, C, or N; X1, X2, W1, and W2 are each independently either C or N; X3, X4, X5, X6, and X9 are each independently defined as in equation (IA'); B is - Haro(C 1~5 Alkyl), unsubstituted C 1~5 Alkyl or unsubstituted -C 2~5 Alkenil- and; R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxyl, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 member heteroaryls, wherein the substituted phenyl or 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -(C 1~6 Alkyl)-NH2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1-4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -(C 1~4 Alkyl)-NH2,-(C 1~4 Alkyl)-C 1~4 Alkoxy, and -CO2(C 1~4 Selected from alkyl groups; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R 4 and R 6 is H; R 14 and R C2 Each is independent, either non-existent or C 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may also be substituted with a more preferred substituent; R16 and R C1 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl; R 15 , R 17 , R 18 , or R 19 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl, and here C 1~4 Alkyl is a halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d It may be substituted with a more preferred substituent; and Each R I and R II (C 1~6 It is alkyl)oxy-; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(RI R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0362] In some embodiments, the compound is a compound of formula (I-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, where X9 is CR 4 That is the case.

[0363] In some embodiments, the compound is the compound of formula (II-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof: TIFF0007843695000049.tif55128In formula, Y2 and Z2 are independently O, S, C, or N; X2 and W2 are independently either C or N; X3, X4, X5, X6, and X9 are each independently defined herein; B is - Haro(C 1~5 Alkyl), unsubstituted-C 1~5 Alkyl or unsubstituted -C 2~5 Alkenil- and; R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxyl, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 member heteroaryls, wherein the substituted phenyl or 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -(C 1~6 Alkyl)-NH2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), -(C 1~4 Alkyl)-NH2,-(C 1~4 Alkyl)-C 1~4 Alkoxy, and -CO2(C 1~4 Selected from alkyl groups; Each R f (C) is independently H, hydroxy, or (C) 1~4 Alkyl) is; R 4 and R 6 is H; R C2 It does not exist, or C 1~4 It is alkyl or -CH2COOH; R 16 and R C1 Each is independent, either nonexistent, H, or C. 1~4 It is alkyl; R 17 , R 18 , or R 19Each is independent, either does not exist, or H, C 1~4 Alkyl, or halo(C) 1~4 Alkyl) and Each R I and R II (C 1~6 It is alkyl(oxy).

[0364] In some embodiments, the compound is a compound of formula (II-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, where X9 is CR 4 That is the case.

[0365] In some embodiments, the compound is a compound of formula (I-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, wherein, R A2 and R A1 These are independently H, halogen, amino, and amino(C) 1~4 Alkyl)-, hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxyl, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 member heteroaryls, wherein the substituted phenyl or 5-6 member heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -(C 1~6 Alkyl)-NH2, and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each alkoxy; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C 2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0366] In some embodiments, the compounds of the present disclosure have formula (I-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, wherein, R A2 and R A1 These are independently H, halogen, hydroxyl, amino, and amino(C) 1~4 Alkyl)-, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, Here, the substitution may be made (C 1~6 Alkyl) or may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxyl, C 1~4 Alkoxyl, -N(R e )(R f ), -CO2(R f ), may be substituted with 1 to 4 substituents independently selected from the group comprising substituted phenyl and substituted 5-6 membered heteroaryls, wherein the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-, Halo(C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-, and C 1~4 Alkoxy-(C) 1~4 The alkoxy(-) group may be substituted with 1 to 4 substituents independently selected from each of them; and R e is H, (C 1~4 Alkyl), -CO(C 1~4 Alkyl), -OCO(C 1~4 Alkyl), or -CO2(C 1~4 Alkyl) is; However, at least one of (i), (ii), or (iii) applies: (i) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C; or (c) Z1 and Y1 are each N and W1 and X1 are each C; or (d) Z2 and Y2 are each N and W2 and X2 are each C; or (e) W1 and X1 are each N and Z1 and Y1 are each C; or (f) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X3 and X4 is S; or X9 is N; or, (ii) (a) Z1, Z2, Y1, and Y2 are each N and W1, W2, X1, and X2 are each C; or (b) W1, W2, X1, and X2 are each N and Z1, Z2, Y1, and Y2 are each C, R 14 is halogen, -OR c , -NR c R d , -CO2R c ,-CONR c R d -SO2NR c R d , and -OCONR c R d C replaced by 1~4 It is alkyl, and here R c is H; or, (iii) (a) Z1 and Y1 are each N and W1 and X1 are each C; or (b) Z2 and Y2 are each N and W2 and X2 are each C; or (c) W1 and X1 are each N and Z1 and Y1 are each C; or (d) If W2 and X2 are each N and Z2 and Y2 are each C, then at least one of X5, X6, and X9 is N and R A1 or R A2 (C) may be substituted with halogens, hydroxyls, or other elements. 1~6 Alkyl), substituted (C1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 It is alkyl)amino-, Here, the substitution may be made (C 1~6 Alkyl), substituted (C 1~6 Alkyl)oxy-, may be substituted (C 1~6 Alkyl)amino-, or possibly substituted (C 1~6 Alkyl)(C 1~4 Alkyl)amino-(C 1~6 Alkyl) is hydroxy, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), -CO2(R f ), -CON(R e )(R f ), may be substituted with 1 to 4 substituents independently selected from substituted phenyl and substituted 5-6 membered heteroaryl groups, where the substituted phenyl or 5-6 membered heteroaryl is a halogen, hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, amino, (C 1~6 Alkyl)amino-, (C 1~6 Alkyl)(C 1~6 Alkyl)amino-,-(C 1~6 Alkyl)-NH2, Halo(C 1~6 Alkyl), hydroxy-(C 1~4 Alkyl)-,-(C 1~4 Alkyl)-OP(O)(OH)2,-(C 1~4 Alkyl)-OP(O)(R I R II )2, Haro (C 1~4 Alkoxy)-, C 1~4 Alkoxy-,hydroxy-(C 2~4 Alkoxy)-,-(C 2~4 Alkoxy)-OP(O)(OH)2,-(C2~4 Alkoxy)-OP(O)(R I R II )2, -C 1~4 Alkyl-(C 1~4 Alkoxy), and C 1~4 Alkoxy-(C) 1~4 They may be substituted with 1 to 4 substituents independently selected from each of the alkoxy- substituents.

[0367] In some embodiments, the compound is a compound of formula (I-B'), (II-B'), (I-b'), or (II-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, where R A2 and R A1 These are independently H, halogen, hydroxyl, amino, and amino(C) 1~4 Alkyl)-, may be substituted (C 1~6 Alkyl), or possibly substituted (C 1~6 It is alkyl)oxy-, and the substituted (C) is also alkyl. 1~6 Alkyl), may be substituted (C 1~6 C of alkyl)oxy 1~6 Alkyl is hydroxyl, -OP(O)(OH)2, -OP(O)(R I R II )2, -N(R e )(R f ), C 1~4 Each R may be substituted with 1 to 4 substituents independently selected from the group comprising alkoxyls, phenyls, and substituted 5-6 member heteroaryls containing at least one nitrogen or oxygen as a ring member; e H and (C 1~4 Alkyl), -(C 1~4 Alkyl)-NH2, and -(C 1~4 Alkyl)-C 1~4 Selected from alkoxys; and each R f (C) is independently H, hydroxy, or (C) 1~4 It is alkyl.

[0368] In some embodiments, the compound is a compound of formula (I-B'), (II-B'), (I-b'), or (II-b'), or a prodrug, solvate, pharmaceutically acceptable salt, or tautomer thereof, where R A2 and R A1 These are independently H, halogen, hydroxyl, amino, and amino(C) 1~4 Alkyl)-, may be substituted (C 1~...

Claims

1. Compounds of formula (V-f1), formula (V-f2), formula (V-f3), formula (V-f4), formula (V-f5), formula (V-f6), formula (V-f7), formula (V-h1), formula (V-h2), formula (V-h3), formula (V-h4), formula (V-h5), formula (V-h6), or formula (V-h7), or their solvates, pharmaceutically acceptable salts, or tautomers: During the ceremony, Y 1 , Y 2 , Z 1 , and Z 2 Each of these is independently O, S, C, or N; X 1 , X 2 , W 1 , and W 2 Each is independently either C or N; X 3 and X 4 are, when present, each independently S or NR f ; X 5 is N or CR A2 and; X 6 If present, N or CR A1 and; X 9 If present, it is N or CH; R 3 and R 5 Each of them is independent of -CON(R d )(R f ), -CH 2 N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH 2 N(R d )CO(R f ) or R 3 and R 5 One of them is -CON(R d )(R f ), -CH 2 N(R d )(R f ), -N(R d )(R f ), -N(R d )CO(R f ), or -CH 2 N(R d )CO(R f ) and R 3 and R 5 The other of these is H, -COOH, or -CO 2 R C and; R c is H, or C 1～4 It is alkyl; R A1 and R A2 If present, each is independently a halogen, hydroxyl, or possibly substituted C 1～6 Alkyl, substituted (C 1～6 Alkyl)oxy-, may be substituted (C 1～6 Alkyl)amino-, or possibly substituted (C 1～6 Alkyl)(C 1～4 It is alkyl)amino-, Here, the C which may be substituted 1～6 Alkyl or substituted (C 1～6 C of alkyl)oxy 1～6 Alkyl is hydroxy, C 1～4 Alkoxyl, -N(R e )(R f ), -CO 2 (R f ), -CON(R e )(R f ), and -COOH may be substituted with 1 to 4 substituents independently selected from each; Each R d These are independently H, hydroxyl, or C 1～4 It is alkyl; Each R e H and C are independent of each other. 1～4 Alkyl, -CO(C 1～4 Alkyl), -OCO(C 1～4 Alkyl, and -CO 2 (C 1～4 Selected from alkyl groups; Each R f These are independently H, hydroxyl, or C 1～4 It is alkyl; R 14 and R C2 are each independently absent or C 1～4 alkyl, where C 1～4 alkyl is optionally substituted with a substituent selected from halogen, -OR c , -NR c R d , -CO 2 R c , -CONR c R d , -SO 2 NR c R d , and -OCONR c R d ; and may be substituted with substituents selected from R 16 and R C1 Each is independent, either nonexistent, H, or C. 1～4 It is alkyl; and R 15 、R 17 、R 18 、or R 19 is each independently absent, H, halogen, or C 1～4 alkyl, where C 1～4 alkyl is halogen, -OR c 、-NR c R d 、-CO 2 R c 、-CONR c R d 、-SO 2 NR c R d 、and -OCONR c R d and may each independently be substituted with one or more substituents selected from; or, R 15 and R 19 They, together with one or more atoms connecting them, form a 5-6 membered ring; or, R 17 and R 18 They, together with one or more atoms connecting them, form a 5-6 membered ring; or, At least one of ring 1 and ring 2 is independently as follows: Selected from.

2. The compound according to claim 1, which is a compound of formula (V-i1), formula (V-i2), formula (V-i3), formula (V-i4), formula (V-i5), formula (V-i6), or formula (V-i7), or a solvate thereof, a pharmaceutically acceptable salt, or a tautomer thereof: 。

3. The compound according to claim 1, wherein ring 2 is selected from the following: 。

4. The compound according to claim 1, wherein ring 1 is selected from the following: 。

5. R 14 However, it does not exist or C 1～4 The compound according to claim 1 or 3, wherein it is alkyl.

6. The following: and A compound selected from, or its solvate, its tautomer, or a pharmaceutically acceptable salt thereof.

7. The aforementioned compound is as follows: The compound according to any one of claims 1 to 6, which is either a solvate thereof, a pharmaceutically acceptable salt thereof, or a tautomer thereof.

8. The aforementioned compound is as follows: The compound according to any one of claims 1 to 6, which is either a solvate thereof, a pharmaceutically acceptable salt thereof, or a tautomer thereof.

9. An antibody-STING agonist conjugate wherein the STING agonist is a compound according to any one of claims 1 to 8.

10. A pharmaceutical composition comprising a compound according to any one of claims 1 to 8 or a conjugate according to claim 9, and one or more pharmaceutically acceptable excipients, diluents, or adjuvants.

11. A pharmaceutical composition for the treatment or prevention of STING-mediated diseases or disorders in a subject, comprising a compound according to any one of claims 1 to 8, a conjugate according to claim 9, or a pharmaceutical composition according to claim 10.

12. Use of a compound according to any one of claims 1 to 8, a conjugate according to claim 9, or a pharmaceutical composition according to claim 10 in the manufacture of a pharmacopoeia for the treatment or prevention of STING-mediated diseases or disorders in a subject.

13. The pharmaceutical composition according to claim 10 or 11, wherein the pharmaceutical composition is administered in combination with at least one immunomodulator.

14. The pharmaceutical composition according to claim 11, wherein the STING-mediated disease or disorder is cancer.

15. The pharmaceutical composition according to claim 14, wherein the cancer is breast cancer, head and neck cancer, gastric cancer, melanoma, renal cell carcinoma (RCC), esophageal cancer, non-small cell lung cancer, prostate cancer, colorectal cancer, ovarian cancer, or pancreatic cancer.

16. The use according to claim 12, wherein the pharmaceutical is a pharmaceutical intended for administration in combination with at least one immunomodulator.

17. The use according to claim 12 or 16, wherein the STING-mediated disease or disorder is cancer.

18. The use according to claim 17, wherein the cancer is breast cancer, head and neck cancer, gastric cancer, melanoma, renal cell carcinoma (RCC), esophageal cancer, non-small cell lung cancer, prostate cancer, colorectal cancer, ovarian cancer, or pancreatic cancer.

19. A method for preparing the compound according to any one of claims 1 to 8, comprising one or more steps described in schemes 1, 3 to 5, and 9 to 11 below: Scheme 1: Scheme 3: Scheme 4: Scheme 5: Scheme 9: Scheme 10: and Scheme 11: 。

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