INSECTICIDAL COMPOSITIONS RESISTANT TO DEGRADATION OF THE ACTIVE INGREDIENT AND PROCESS FOR THE PREPARATION OF THESE.

Abstract

The present invention provides compositions comprising phosphoramidothioates that are resistant to degradation of the active ingredient. The invention provides a process for preparing granular compositions comprising acephate that are resistant to degradation of the active ingredient, wherein said process comprises the use of a mixture of water and an electrolyte.

Description

INSECTICIDAL COMPOSITIONS RESISTANT TO DEGRADATION OF THE ACTIVE INGREDIENT AND PROCESS FOR THEIR PREPARATION Field of invention The present invention relates to insecticidal compositions resistant to degradation of the active ingredient. The present invention provides compositions comprising phosphoramidothioates that are resistant to degradation of the active ingredient. The present invention further provides a process for preparing granular compositions comprising phosphoramidothioates that are resistant to degradation of the active ingredient, wherein said process comprises the use of water and an electrolyte. Background of the invention Phosphoramidothioates are known for their excellent insecticidal activity against a variety of insects in various environments. Acetate, a systemic insecticide, is a widely used phosphoramidothioate that controls a broad range of chewing and sucking insects, e.g., aphids, thrips, lepidopteran larvae, sawflies, leafminers, leafhoppers, cutworms, etc., on fruit (including citrus), climbing plants, hops, olives, cotton, soybeans, peanuts, macadamia nuts, beets, brassicas, celery, beans, potatoes, rice, tobacco, ornamental plants, forestry, and other crops. Phosphoramidothioates are known to suffer from stability problems due to their hydrolytic sensitivity. Attempts have been made to address the acetate degradation issue and to produce a stable insecticidal product. Some of these methods include using solvents as extrusion aids, maintaining specific temperature conditions during extrusion, employing specialized equipment such as compaction aids and other stabilizers, and adopting special procedures. rfrQQcni znz-i / YiAi US Patent No. 5298501 describes chemically stable insecticidal compositions of phosphoramidothioates. The compositions comprise at least 83% ammonium sulfate, effective for granulating the insecticidal components. In the absence of ammonium sulfate, the composition is affected by chemical stability problems due to the hydrolytic and catalytic-driven degradation of the phosphoramidothioates, which in turn shortens the product's shelf life. US Patent No. 5464623 describes a method for preparing stable insecticidal compositions comprising acetate. The method involves mixing the dry insecticidal composition with 3–25% of a solvent to form a moist, sandy slime consistency, and then extruding it. A preferred solvent should have high volatility so that the granules can be dried. The method also uses a dehydrating agent to absorb trace amounts of water present in the granules to prevent hydrolysis of the insecticide. The method is highly unsafe for the environment. What has been needed for some time is a granulation technique that uses commonly operated granulation equipment, avoiding the use of special solvents, techniques or equipment that are unsafe for the environment. The inventors of the present invention established a safe and environmentally friendly formulation method using water as a medium, resulting in a stable insecticidal composition comprising acetate. Objects of the invention An object of the present invention is to provide an environmentally safe granulation process for compositions comprising phosphoramidothioates. Another object of the present invention is to provide a composition comprising phosphoramidothioates that is resistant to degradation of the active ingredient. rfrQQcni znz-i / YiAi Brief description of the invention In one aspect, the present invention provides a composition comprising: a) a phosphoramidothioate; and b) an electrolyte; where said composition is formulated using a mixture of water and said electrolyte. In another aspect, the present invention provides a stable, degradation-resistant composition of the active ingredient comprising: c) a phosphoramidothioate as an active ingredient; and d) an electrolyte; where said composition is formulated using a mixture of water and said electrolyte. In another aspect, the present invention provides a degradation-resistant composition of the active ingredient comprising: a) acetate; and b) an electrolyte; where said composition is formulated using a mixture of water and said electrolyte. In another aspect, the present invention provides a degradation-resistant composition of the active ingredient comprising: a) a phosphoramidothioate as an active ingredient; b) an electrolyte; and c) one or more active ingredients; where said composition is formulated using a mixture of water and said electrolyte. In another aspect, the present invention provides a process for preparing the phosphoramidothioate composition resistant to degradation of the active ingredient, said process comprising: Step 1: Prepare a mixture of water and an electrolyte; pbapcn / Lzzza / YiAi Step 2: Prepare a combination of phosphoramidothioate, remaining electrolyte, if any, and other excipients; Step 3: Prepare an addition mixture of the combination from step 2 with said mixture from step 1; and Step 4: Formulate in a suitable form using appropriate equipment. In another aspect, the present invention provides a process for preparing the phosphoramidothioate composition resistant to degradation of the active ingredient, said process comprising: Step 1: Prepare a mixture of water and an electrolyte; Step 2: Prepare a combination of phosphoramidothioate, remaining electrolyte, if any, one or more other active ingredients and other excipients; Step 3: Prepare an addition mixture of the combination from step 2 with said mixture from step 1; and Step 4: Formulate in a suitable form using appropriate equipment. In another aspect, the present invention provides a process for preparing an acetate composition resistant to degradation of the active ingredient, said process comprising: Step 1: Prepare a mixture of water and an electrolyte; Step 2: Prepare a combination of acetate, remaining electrolyte, if any, and other excipients; Step 3: Prepare an addition mixture of the combination from step 2 with the mixture from step 1; and Step 4: Formulate in a suitable form using appropriate equipment. In another aspect, the present invention provides a method for controlling insects, comprising applying an effective amount of a composition according to the present invention to an area to be treated. FbQPcn / Lzzza / YiAi The additional features and advantages of the present invention will become evident from the following detailed description, which illustrates by way of example the features with the highest preference of the proposed invention, which should not be interpreted as limiting the scope of the invention described herein. Detailed description of the invention Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by a person skilled in the art to which this invention pertains. It should be noted that, as used in this specification, the singular forms “a,” “an,” and “the” include plural referents unless the content clearly indicates otherwise. The term “approximately” used to describe the amounts of mancozeb and carbendazim should be interpreted as “around” or “reasonably close to” and any statistically insignificant variation from these. As used herein, the terms “comprising,” “including,” “having,” “containing,” “involving,” and the like are to be understood as open-ended, that is, meaning that they include, but are not limited to. The terms “preferred” and “preferably” refer to embodiments of the invention that may provide certain benefits under certain circumstances. In one modality, the aspects and modalities described in this description shall also be interpreted as replacing the clause “comprising” with “consisting of” or with “consisting essentially of” or with “consisting substantially of”. The present invention provides a degradation-resistant composition of the active ingredient. It has been observed that moisture-sensitive active ingredients require specific equipment and conditions to prepare stable commercial products. Surprisingly, the inventors of the present invention discovered that stable compositions can be prepared by a suitable process comprising the use of water and an electrolyte when using a moisture-sensitive active ingredient. Furthermore, the pbapcn / Lznza / YiAi method can be used when combination products are prepared with a moisture-sensitive active ingredient. Therefore, the present invention provides a composition that is resistant to degradation of the active ingredient. The present invention provides a composition comprising: a) a phosphoramidothioate as an active ingredient; and b) an electrolyte; where said composition is formulated using a mixture of water and said electrolyte. In one embodiment, the phosphoramidothioate active ingredient is selected from acetate, chloramine phosphorus, isocarbophos, isophenphos, isophenphos, methamidophos, isophenphos-methyl, phosglycine, or propetamphos. In a preferred embodiment, the active ingredient of phosphoramidothioate is acetate. The present invention provides a degradation-resistant composition of the active ingredient comprising: a) acetate; and b) an electrolyte; where said composition is formulated using a mixture of water and said electrolyte. The term degradation refers to chemical degradation. Chemical degradation includes hydrolytic, photolytic, and catalytic degradation. In one embodiment according to the present invention, the degradation of the active ingredient is controlled. In another embodiment according to the present invention, the degradation of acetate is controlled. rfrQQcni znz-i / YiAi In another embodiment according to the present invention, the degradation of acetate is controlled to <5% by weight of acetate in the composition. In one embodiment, in the compositions according to the present invention, the degradation of acetate is controlled even after using water as the medium for formulation. In another embodiment, in the compositions according to the present invention, the degradation of acetate is controlled to less than 5% even after using water as the medium for formulation. In another embodiment, in the compositions according to the present invention, the degradation of acetate is controlled to <3% even after using water as the medium for formulation. In one embodiment, the composition comprises acetate in an amount of approximately 0.1% to approximately 99% by weight of the composition. In another embodiment, the composition comprises acetate in an amount of approximately 1% to approximately 97% by weight of the composition. In one embodiment, water is used as the medium for formulating the compositions according to the present invention. pbapcn / Lzzza / YiAi In one form, the composition comprises an electrolyte. In one embodiment, the composition comprises an electrolyte in an amount of approximately 1% to approximately 97% by weight of the composition. In another embodiment, the composition comprises an electrolyte in an amount of approximately 1% to approximately 50% by weight of the composition. In one modality, the electrolyte is selected from an inorganic or organic salt. In one embodiment, the inorganic salt is selected from the group comprising salts of strong acids with strong bases, strong acids with weak bases, weak acids with strong bases, and weak acids with weak bases. In a preferred embodiment, an inorganic salt is a salt of a strong acid with a weak base. In one modality, the inorganic salt is selected from ammonium salts, strips of alkali and alkaline earth metals, etc. In another modality, the inorganic salt is selected from phosphates, carbonates, sulfates, chlorides, nitrates, oxides and hydroxides, etc. In another modality, the organic salt is selected from alkali or alkaline earth metal salts of an organic acid. In yet another form, the organic salt is selected from alkali metal salts of a weak organic acid. In another sense, weak organic acids include acetic acid, oxalic acid, citric acid, tartaric acid, propionic acid, and the like. In one embodiment, the electrolyte is selected from the group comprising sodium chloride, calcium chloride, potassium chloride, magnesium chloride, sodium acetate, calcium acetate, magnesium carbonate, sodium carbonate, calcium carbonate, potassium carbonate, calcium phosphate, sodium phosphate, ammonium phosphate, diammonium phosphate dihydrate, magnesium phosphate, ammonium sulfate, ammonium chloride, ammonium acetate, magnesium sulfate, sodium sulfate, calcium sulfate, zinc sulfate, sodium acetate, calcium oxalate, calcium acetate, trisodium citrate and the like. In one embodiment, the present invention provides a composition that is resistant to degradation of the active ingredient comprising: a) a phosphoramidothioate as an active ingredient; pbapcn / Lzzza / YiAi b) an electrolyte; and c) one or more active ingredients; where said composition is formulated using a mixture of water and said electrolyte. In one embodiment, the compositions according to the present invention comprise one or more of the other active ingredients. In one embodiment, another active ingredient that may be present in compositions according to the present invention is selected from insecticides, attractants, bactericides, acaricides, nematicides, fungicides, herbicides, and growth regulators. In another embodiment, the active ingredient that may be present in compositions according to the present invention is selected from an organophosphorus compound, a chloronicotinyl compound, a diamide insecticide, a chitin synthesis inhibitor benzoylphenylurea, or a pyrethroid compound. In another form, the organophosphorus compound may be selected, but is not limited to, aspon, azinphos-methyl, carbofuran, carbophenothione, chlorfenvinphos, chlorpyrifos, coumaphos, crotoxyphos, crufomate, demetone, diazinon, dichlorvos, dicrotophos, dimethoate, dioxathion, disulfoton, EPN, ethion, ethoprop, famfur, fenamiphos, fenitrothion, fensulfothion, fenthione, phonophos, isofenphos, malathion, methamidophos, methidathion, methyl parathion, mevinphos, monocrotophos, metam sodium, naled, oxidemetonmethyl, parathion, phorate, phosalone, phosmet, phosphamidon, profenophos, temephos, TEPP, terbufos, tetrachlorvinphos, trichlorfon, cypermethrin, fenvalerate, permethrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin, and / or bioresmethrin, afoxolaner broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprol, cyhalodiamide, flubendiamide, fluralaner, lotilaner, tetrachlorantraniliprole tetraniliprol bistrifluron, chlorbenzuron, chlorfluazuron,dichlorbenzuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron, triflumuron, or mixtures thereof. pbapcn / Lzzza / YiAi In another modality, the chloronicotinyl compound may be selected, but is not limited to acetamiprid, imidacloprid, thiacloprid, thiamethoxam and combinations thereof. In another modality, the pyrethroid may be selected, but is not limited to cypermethrin, fenvalerate, permethrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin and / or bioresmethrin or mixtures thereof. In another embodiment, the active ingredient that may be present in the compositions according to the present invention is selected from nitrotalisopropyl, myclobutanil, piproctanil bromide, jodfenphos, imazalyl, lambda-cyhalothrin, triflumizole, vamidothion, xylylcarb, tolclofos-methyl, protoate, pyriproxyfen, propamocarb hydrochloride, tefluthrin, resmethrin, chloropropam, cloetocarb, demetone-S, cyfluthrin, azinphos-ethyl, azinphos-methyl, benalaxyl, benazolin-ethyl, butocarboxim, benzoximate, bioresmethrin, bromopropylate, borax, biphenyl, fluoroglycophen-ethyl, fenbucarb, fenthiocarb, fensulfothion, fosmethylan, furalaxyl, diquegulac, trinexapac-ethyl, etiofencarb, etridiazole, fenamifos, phenazaquine, EPN, dodemorph, mecarfon, etaconazole, fluorbenside, furmeciclox, fenfluthrin, fluenethyl, acequinocil, schradan, transfluthrin, cyprodinil, fosfolan, crufomate, chlorfoxim, chloropropylate, dialate, chlorofenprop, camphechlor, chlorbenside, chlordimeform, phosphonic acid, trifloxystrobinpicoxystrobin, gamma-cyhalothrin, codlemone, spinetoram, cyflumetofen., The invention further provides a degradation-resistant composition of the active ingredient comprising: a) Acetate as an active ingredient; b) an electrolyte; and c) one or more other active ingredients; where said composition is formulated using a mixture of water and said electrolyte. In another embodiment, another active ingredient that may be present in compositions according to the present invention is selected from an organophosphorus compound, a chloronicotinyl compound, or a pyrethroid compound. In another embodiment, said active ingredient that may be present in compositions according to the present invention is selected from acetamiprid, imidacloprid, thiacloprid, thiamethoxam, cypermethrin, fenvalerate, permethrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin, bioresmethrin or mixtures thereof. In one modality, the electrolyte is selected from an inorganic or organic salt. In a preferred embodiment, an inorganic salt is a salt of a strong acid with a weak base. In one modality, the inorganic salt is selected from ammonium salts, strips of alkali and alkaline earth metals, etc. In another modality, the inorganic salt is selected from phosphates, carbonates, sulfates, chlorides, oxides and hydroxides, etc. In another sense, weak organic acids include acetic acid, oxalic acid, citric acid, tartaric acid, propionic acid, and the like. In one embodiment, the electrolyte is selected from the group comprising sodium chloride, calcium chloride, potassium chloride, magnesium chloride, sodium acetate, calcium acetate, magnesium carbonate, sodium carbonate, calcium carbonate, potassium carbonate, calcium phosphate, sodium phosphate, ammonium phosphate, diammonium phosphate dihydrate, magnesium phosphate, ammonium sulfate, ammonium chloride, ammonium acetate, magnesium sulfate, sodium sulfate, calcium sulfate, zinc sulfate, sodium acetate, calcium oxalate, calcium acetate, trisodium citrate and the like. Therefore, in one embodiment the invention provides a degradation-resistant composition of the active ingredient comprising: rfrQQcni znz-i / YiAi a) Acephate; b) an electrolyte; and c) one or more active ingredients selected from acetamiprid, imidacloprid, thiacloprid, thiamethoxam, cypermethrin, fenvalerate, permethrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin, bioresmethrin or mixtures thereof; where said composition is formulated using a mixture of water and said electrolyte. In one embodiment, the invention provides a degradation-resistant composition of the active ingredient comprising: a) Acephate; b) an electrolyte; and c) acetamiprid, wherein said composition is formulated using a mixture of water and said electrolyte. In another embodiment, the invention provides a degradation-resistant composition of the active ingredient comprising: a) Acephate; b) an electrolyte; and c) beta-cypermethrin, wherein said composition is formulated using a mixture of water and said electrolyte. In another embodiment, the invention provides a degradation-resistant composition of the active ingredient comprising: a) Acephate; b) an electrolyte; and c) bifenthrin, wherein said composition is formulated using a mixture of water and said electrolyte. FbQPcn / Lzzza / YiAi In yet another embodiment, the invention provides a degradation-resistant composition of the active ingredient comprising: a) Acetate; b) an electrolyte; and c) imidacloprid, wherein said composition is formulated using a mixture of water and said electrolyte. In one embodiment, the present invention provides a process for preparing a degradation-resistant composition of the active ingredient, said process comprising: Step 1: Prepare a mixture of water and electrolyte; Step 2: Prepare a combination of phosphoramidothioate, remaining electrolyte, if any, and other excipients as required; Step 3: Prepare an addition mixture of the combination from step 2 with said mixture from step 1; and Step 4: Formulate the mixture in a suitable form using appropriate equipment. In another embodiment, the present invention provides a process for preparing a degradation-resistant composition of the active ingredient, said process comprising: Step 1: Prepare a mixture of water and electrolyte in a required measure; Step 2: Prepare a combination of acetate, remaining electrolyte, if any, with other excipients as required; Step 3: Prepare an addition mixture of the combination from step 2 with the mixture from step 1; and Step 4: Formulate a mixture in a suitable form using appropriate equipment. In one form, the composition also includes one or more other active ingredients. In another embodiment, the present invention provides a process for preparing a degradation-resistant composition of the active ingredient, said process comprising: pbapcn / Lzzza / YiAi Step 1: Prepare a mixture of water and electrolyte in a required measure; Step 2: Prepare a combination of acetate, remaining electrolyte, if any, with one or more other active ingredients and other excipients, as required; Step 3: Prepare an addition mixture of the combination from step 2 with the mixture from step 1; and Step 4: Formulate a mixture in a suitable form using appropriate equipment. In one modality, the process involves the use of electrolytes. In one modality, the electrolyte is selected from an inorganic or organic salt. In one embodiment, the inorganic salt is selected from the group comprising salts of strong acids with strong bases, strong acids with weak bases, weak acids with strong bases, and weak acids with weak bases. In a preferred embodiment, an inorganic salt is a salt of a strong acid with a weak base. In one modality, the inorganic salt is selected from ammonium salts, strips of alkali and alkaline earth metals, etc. In another modality, the inorganic salt is selected from phosphates, carbonates, sulfates, chlorides, oxides and hydroxides, etc. In another modality, the organic salt is selected from alkali or alkaline earth metal salts of an organic acid. In yet another form, the organic salt is selected from the salts of alkali or alkaline earth metals of a weak organic acid. In another sense, weak organic acids include acetic acid, oxalic acid, citric acid, tartaric acid, propionic acid, and the like. pbapcn / Lzzza / YiAi In one modality, the electrolyte is used as a mixture in water in the process of making the composition. In another modality, the mixture of electrolyte and water includes solutions, suspensions and the like. In one modality, water is used in an amount of approximately 1% to approximately 40% by weight of the composition suitable for the process. In another modality, water is used in an amount of approximately 1% to approximately 20% by weight of the composition suitable for the process. In another modality, water is used in an amount of approximately 1% to approximately 10% by weight of the composition suitable for the process. In another modality, the amount of electrolyte required to make a mixture in water varies from approximately 1% to approximately 25% by weight of the composition. In yet another modality, the amount of electrolyte required to make a mixture in water varies from approximately 1% to approximately 15% by weight of the composition. In one modality, the proper process for composition requires water and electrolyte in a ratio of approximately 1:1 to approximately 1:20. In another modality, the appropriate process for composition requires water and electrolyte in a ratio of approximately 1:1 to approximately 1:10. In one modality, in step 2, preparing a combination of acetate, electrolyte and other excipients, optionally with other active ingredients, is not particularly limiting. pbapcn / Lzzza / YiAi In one embodiment, in step 3, preparing an addition mixture of the product from step 2 with a mixture from step 1 is not particularly limiting. In one embodiment, in step 3, said addition mixture is prepared by spraying the mixture from step 1 onto the product from step 2. In another embodiment, in stage 3, this addition mixture is prepared by the discontinuous addition of the mixture from stage 1 onto the product from stage 2. In one modality, in stage 4, the formulation process is not particularly limiting. In a preferred embodiment, in stage 4, the composition is formulated as granules. In one modality, stage 4 of the process uses readily available commercial extrusion equipment. In one modality, in stage 4 of the process, the moisture in the granules was significantly reduced. In one embodiment, the present process provides granules with at least a partial or complete moisture barrier on the surface of the material to prevent its degradation. In one embodiment, the moisture barrier comprises an electrolyte. In another sense, the term granules refers to tablets, granules, solid grains and the like. Typically, the process for preparing the degradation-resistant composition of the active ingredient comprises preparing a mixture of water and electrolyte (Part A); preparing a combination of phosphoramidothioate, remaining electrolyte (Part B), optionally with one or more active ingredients and other excipients; preparing a FbQPcn / Lznza / YiAi combination by mixing a mixture of Part A and Part B; and formulating a mixture in a suitable form using suitable equipment. Preferably, the process is carried out at room temperature and the mixture is extruded using a basket extruder to obtain granules. The granules are dried (until the moisture content is <1%) and then packaged. The formulation is prepared using the wet granulation method known to an expert in the technique. The stable insecticidal compositions of the present invention may further comprise one or more dispersants, wetting agents, carriers, anti-caking agents, pH regulating agents, preservatives, biocides, anti-foaming agents, colorants, and other formulation aids. Dispersants can be selected from ionic and non-ionic dispersants, such as polystyrene sulfonic acid salts, polyvinylsulfonic acid salts, naphthalenesulfonic acid / formaldehyde condensate salts, naphthalenesulfonic acid condensate salts, phenolsulfonic acid and formaldehyde salts, and lignosulfonic acid salts, polyethylene oxide / polypropylene oxide block copolymers, polyethylene glycol ethers of linear alcohols, reaction products of fatty acids with ethylene oxide and / or propylene oxide, plus polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl alcohol and polyvinylpyrrolidone copolymers and (meth)acrylic acid copolymers and (meth)acrylic esters, plus alkyl ethoxylates and alkylaryl ethoxylates of alkylaryl phosphate ethoxylate and sulfate ester. Wetting agents may be selected from aliphatic monoester salts of sulfuric acid including, but not limited to, sodium lauryl sulfate; sulfoalkylamides and their salts, including, but not limited to, Na salt of N-methyl-N-oleoyltaurate; alkylaryl sulfonates including, but not limited to, alkylbenzenesulfonates; alkylnaphthalenesulfonates and their salts; and ligninsulfonic acid salts. rfrQQcni znz-i / YiAi Carriers may include clays, silicas, sulfates, chlorides, carbohydrates, alkylated celluloses, etc. In one embodiment, the present invention provides a method for controlling insects, comprising applying an effective amount of a composition according to the present invention to an area to be treated. In one embodiment, a method for controlling insects is provided, comprising applying to an area to be treated an effective quantity of a degradation-resistant composition of the active ingredient, comprising: a) a phosphoramidothioate; and b) an electrolyte; where said composition is formulated using a mixture of water and said electrolyte. In one embodiment, a method for controlling insects is provided, comprising applying to an area to be treated an effective quantity of a degradation-resistant composition of the active ingredient, comprising: a) acetate; and b) an electrolyte; where said composition is formulated using a mixture of water and said electrolyte. In another embodiment, a method for controlling insects is provided, comprising applying to an area to be treated an effective quantity of a degradation-resistant composition of the active ingredient comprising: a) a phosphoramidothioate; b) an electrolyte; and c) one or more active ingredients; where said composition is formulated using a mixture of water and said electrolyte. In another embodiment, a method for controlling insects is provided, comprising applying to an area to be treated an effective quantity of a degradation-resistant composition of the active ingredient comprising: rfrQQcni znz-i / YiAi a) Acephate; b) an electrolyte; and c) one or more active ingredients; where said composition is formulated using a mixture of water and said electrolyte. In one embodiment, the present invention can provide methods for controlling insects, such as those belonging to the insect classes Lepidoptera, Coleoptera, Diptera, Hemiptera. Accordingly, the present invention provides a method for controlling insects, comprising applying to an area to be treated an effective quantity of a composition comprising: a) acephate; and b) an electrolyte; c) optionally one or more active ingredients; where said composition is formulated using a mixture of water and said electrolyte. In another embodiment, the method comprises applying to an area to be treated an effective quantity of a composition comprising: a) acephate; b) an electrolyte; and c) one or more active ingredients; where said composition is formulated using a mixture of water and said electrolyte. In another embodiment, the present invention provides for the use of a composition to control insects. The present invention is explained more specifically by the examples below. However, it should be understood that the scope of the present invention is not limited by the examples in any way. Anyone skilled in the art will appreciate that the present invention includes the examples below and may also be modified and varied within the technical scope of the present invention. FbQPcn / Lzzza / YiAi Examples Example 1: An acetate and beta-cypermethrin composition was prepared according to the present invention as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Sodium acetate 3.64 Precipitated silica 0.35 Water 4.0 b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Sodium acetate 3.64 Precipitated silica 0.35 rfrQQcni znz-i / YiAi c) Process: A weighed amount of sodium acetate was added to water (4 ml) to prepare a mixture (Part A). The weighed amounts of acetate and precipitated silica were thoroughly mixed. Beta-cypermethrin, sodium laulsulfate, and styrene acrylic polymer dispersant were ground together and mixed with the acetate mixture (Part B) at room temperature. Part B was then mixed with the mixture from Part A to prepare a combination. The combination was then extruded using a basket extruder to obtain granules. The granules were dried (until the moisture content was <1%) and then packaged. Example 2: An acetate composition was prepared according to the present invention, as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 92.04 Ammonium sulfate 6.00 Precipitated silica 1.96 Water 5 b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 92.04 Ammonium sulfate 6.00 Precipitated silica 1.96 FbQPcn / Lzzza / YiAi c) Process: Ammonium sulfate was added to water (5 ml) to prepare a mixture (Part A). Weighed quantities of acetate and precipitated silica were ground using suitable equipment to obtain the required particle size (Part B). Part B was then blended with the mixture from Part A to prepare a combination. This combination was then extruded using a basket extruder to obtain granules. The granules were dried (until the moisture content was <0.6%) and then packaged. Example 3: A composition of acetate and beta-cypermethrin was prepared according to the present invention, as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Calcium chloride 3.64 Precipitated silica 0.35 Water 3.5 rfrQQcni znz-i / YiAi b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Calcium chloride 3.64 Precipitated silica 0.35 c) The composition was prepared according to the process in example 1. Example 4: An acetate and imidacloprid composition was prepared according to the present invention as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Sodium chloride 3.64 Precipitated silica 0.35 Water 3 pfrQPcn / Lzzza / YiAi b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Sodium chloride 3.64 Precipitated silica 0.35 c) The composition was prepared according to the process in example 1. Example 5: An acetate and imidacloprid composition was prepared according to the present invention as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 52.55 Imidacloprid 5.68 Ammonium sulfate 31.62 Aerosil R972 1.0 Anionic dispersant 1.5 Castor oil ethoxylate 6.0 SAG 1572 0.02 Precipitated silica 1.63 Water 10.0 pfrQPcn / Lzzza / YiAi b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 52.55 Imidacloprid 5.68 Ammonium sulfate 31.62 Aerosil R972 1.0 Anionic dispersant 1.5 Castor oil ethoxylate 6.0 SAG 1572 0.02 Precipitated silica 1.63 C) Process: Approximately 10 g of ammonium sulfate were mixed with water (10 ml) to obtain a mixture (Part A). The weighed amount of imidacloprid, the remaining ammonium sulfate, and surfactants were ground using suitable equipment to obtain a mixture with the required particle size. The weighed amount of acetate was then mixed to obtain the mixture for Part B. Parts A and Part B were then combined to prepare a mixture. This mixture was then extruded using an extruder. The resulting product was then dried and packaged. Example 6: An acetate composition was prepared according to the present invention as follows: a) The raw materials used for the composition are listed below: pfrQPcn / Lzzza / YiAi Raw materials Quantity (w / w) Acetate 90 Sodium lauryl sulfate 0.50 Polyvinylpyrrolidone 0.30 Sodium chloride 6.85 Water 4.0 b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 90 Sodium lauryl sulfate 0.50 Polyvinylpyrrolidone 0.30 Sodium chloride 6.85 b) The composition was prepared according to the process in example 2. Example 7: An acetate composition was prepared according to the present invention as follows: a) The raw materials used for the composition are listed below: FbQPcn / Lzzza / YiAi Raw materials Quantity (w / w) Acetate 95 Sodium lauryl sulfate 0.50 Polyvinylpyrrolidone 0.30 Magnesium sulfate 2.24 Water 3.5 b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Sodium lauryl sulfate acetate 95 0.50 Polyvinylpyrrolidone 0.30 Magnesium sulfate 2.24 c) The composition was prepared according to the process in example 2. Example 8: A composition of acetate and beta-cypermethrin was prepared according to the present invention, as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (p / p) Acetate 74 Beta-cypermethrin 6 Styrene acrylic polymeric dispersant 4.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Monoammonium phosphate 10.80 Precipitated silica 0.35 Water 6.0 pfrQPcn / Lzzza / YiAi b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 74.0 Beta-cypermethrin 6.0 Styrene acrylic polymeric dispersant 4.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Monoammonium phosphate 10.80 Precipitated silica 0.35 b) The composition was prepared according to the process in Example 1. Example 9: An acetate and beta-cypermethrin composition was prepared according to the present invention, as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 74.0 Beta-cypermethrin 6.0 Styrene acrylic polymeric dispersant 4.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Diammonium phosphate 10.30 Precipitated silica 0.35 pH modifier 0.5 Water 5.0 pfrppcn / Lzzza / YiAi b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 74.0 Beta-cypermethrin 6.0 Styrene acrylic polymeric dispersant 4.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Diammonium phosphate dihydrate 10.30 Precipitated silica 0.35 pH modifier 0.5 a) The composition was prepared according to the process in example 1. Example 10: FbQPcn / Lzzza / YiAi An acetate and beta-cypermethrin composition was prepared according to the present invention, as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.0 Sodium lauryl sulfate 2.0 Polyvinylpyrrolidone 0.3 Monosodium phosphate 4.11 Precipitated silica 0.35 Water 3.5 b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 85.0 Beta-cypermethrin 3.0 Styrene acrylic polymeric dispersant 3.0 Sodium lauryl sulfate 2 Polyvinylpyrrolidone 0.3 Monosodium phosphate 4.11 Precipitated silica 0.35 rfrQQCn i 7ηΖ =1 / ΥΙΛΙ a) The composition was prepared according to the process in example 1. Example 11: A composition of acephate and beta-cypermethrin was prepared according to the present invention, as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acephate 74 Beta-cypermethrin 6 Styrene acrylic polymeric dispersant 4 Sodium lauryl sulfate 2 Polyvinylpyrrolidone 0.3 Trisodium citrate 10.97 pH modifier 0.5 Precipitated silica 0.35 Water 4.5 b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acephate 74 Beta-cypermethrin 6 Styrene acrylic polymeric dispersant 4 Sodium lauryl sulfate 2 Polyvinylpyrrolidone 0.3 Trisodium citrate 10.97 pH modifier 0.5 Precipitated silica 0.35 pbapcn / Lzzza / YiAi a) The composition was prepared according to the process in example 1. Example 12: An acetate and beta-cypermethrin composition was prepared according to the present invention, as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 85 Beta-cypermethrin 3 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Zinc sulfate 5.27 Precipitated silica 0.35 Water 5.5 b) The final composition of the product is shown in the table below: Raw materials Quantity (w / w) Acetate 85 Beta-cypermethrin 3 Styrene acrylic polymeric dispersant 3.00 Sodium lauryl sulfate 2.00 Polyvinylpyrrolidone 0.30 Zinc sulfate 5.27 Precipitated silica 0.35 Water 5.5 a) The composition was prepared according to the process in example 1. pbapcn / Lzzza / YiAi Example 13: An acetate and bifenthrin composition was prepared according to the present invention as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 76.5 Bifenthrin 6.4 Ammonium sulfate 10.36 Precipitated silica 0.4 Rhodapon 2.0 Polyvinylpyrrolidone 0.3 Water 10.0 b) The final composition of the product is shown in the table below: FbQPcn / Lzzza / YiAi Ingredients Quantity (w / w) Acephate 76.5 Bifenthrin 6.4 Ammonium sulfate 10.36 Precipitated silica 0.4 Rhodapon 2.0 Polyvinylpyrrolidone 0.3 d) Process: The process from example 1 was followed to prepare the composition Stability studies of the compositions according to the present invention: The compositions according to the present invention were analyzed with respect to stability. The samples were kept at 54 ± 2 °C for a maximum of 14 days and stability parameters such as suspensibility, dispersibility, wet sieve analysis and degradation of active ingredients were analyzed. Example 14: The physical parameters of a composition comprising acephate prepared as in Example 2 are presented in the table below: Mr. No. Parameters Environment AHS (14 days) 1 Acephate (%) 89.47 87.78 2 Investment No. 1-2 1-2 3% degradation ND* 1.88 *-not detected rfrQQCn i 7ηΖ =1 / ΥΙΛΙ Example 15: The physical parameters of a composition comprising acetate and imidacloprid prepared as in Example 5 are presented in the table below: Mr. No. Parameters Environment AHS 14 days AHS 28 days 1 Acetate (%) 52.66 52.66 51.65 2 Imidacloprid (%) 5.52 5.49 5.49 5 Inversion No. 2-3 2-3 2-3 6 Wet Sieve None None None 7 Suspensibility 103 102.98 102.80 % degradation of the active ingredient: Active ingredients % degradation 14 days % degradation 28 days Acetate 0 1.91 Imidacloprid 0.54 0.54 Example 16: The physical parameters of a composition comprising acetate and bifenthrin prepared as in Example 13 are presented in the table below Mr. No. Parameters Environment AHS (7 days) AHS (14 days) 1 Acetate (%) 74.80 74.55 74.34 2 Bifenthrin (%) 6.30 6.30 6.29 3 Inversion number 1-2 1-2 1-2 4 Wet sieve None None None 5 Suspensibility 103 102.89 102.20 % degradation of the active ingredient: rfrQQcni znz-i / YiAi Active ingredients % degradation 7 days % degradation 14 days Acetate 0.33 0.61 Bifenthrin NA 0.16 Based on previous experimental results, it has been established that the present invention provides stable compositions comprising acetate. Acetate degradation is substantially controlled, resulting in compositions that can be stored for a longer period. The inventors have further observed that compositions according to the present invention require only a few inversions when dispersing the formulation. (The number of inversions of the formulation is an indicator of the ease of dispersion of the formulation.) The suspensibility of the compositions is also well maintained, resulting in a product that largely satisfies all the requirements for an extended shelf life and for the intended activity of the composition. Comparative examples Comparative example 1: An acetate composition was prepared as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 92.04 Ammonium sulfate 6.00 Precipitated silica 1.96 Water 5 pbapcn / Lzzza / YiAi b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 92.04 Ammonium sulfate 6.00 Precipitated silica 1.96 c) Process: Weighed quantities of acetate and ammonium sulfate were mixed together and ground using suitable equipment to obtain the required particle size. Water was added to prepare a mixture. The mixture was then extruded using a basket extruder to obtain granules. The granules were then dried and packaged. Comparative Example-2 A composition of acetate and imidacloprid was prepared as follows: a) The raw materials used for the composition are listed below: Raw materials Quantity (w / w) Acetate 52.55 Imidacloprid 5.68 Ammonium sulfate 31.62 Aerosil R972 1.0 Anionic surfactant 1.5 Castor oil ethoxylate 6.0 SAG 1572 0.02 Precipitated silica 1.63 Water 10.0 pbapcn / Lzzza / YiAi b) The final composition of the product is shown in the table below: Ingredients Quantity (w / w) Acetate 52.55 Imidacloprid 5.68 Ammonium sulfate 31.62 Aerosil R972 1.0 Anionic surfactant 1.5 Castor oil ethoxylate 6.0 SAG 1572 0.02 Precipitated silica 1.63 C) Process: The same process was followed as in comparative example-1 where heavy quantities of imidacloprid, ammonium sulfate and surfactants were ground using suitable equipment to obtain a mixture with the required particle size. Next, the weighed amount of acetate was mixed to obtain a premix. Water was added to the premix to prepare a compound. The compound was then extruded using an extruder. Finally, the resulting product was dried and packaged. The compositions of comparative examples 1 and 2 were analyzed with respect to stability. The samples were kept at 54 ± 2 °C for a maximum of pbapcn / Lznza / YiAi days and stability parameters such as suspensibility, dispersibility, wet sieve analysis, and degradation of active ingredients were analyzed. The physical parameters of a composition comprising acetate according to comparative example 1 are indicated below: Mr. No. Parameters Environment AHS (14 days) 1 Acetate (%) 88.43 77.95 2 Inversion No. 1-2 12-15 with grit 3 % degradation 11.85 The physical parameters of a composition comprising acetate and imidacloprid according to comparative example 2 are indicated below: Mr. No. Parameters Environment AHS 14 days 1 Acetate (%) 51.51 46.11 2 Imidacloprid (%) 5.45 4.4 5 Inversion No. 2-3 30 with grit 6 Wet sieve None 1.02 7 Suspensibility 103 77.2 % degradation of the active ingredient: Active ingredients % degradation 14 days Acetate 10.48 Imidacloprid 19.26 FbQPcn / Lzzza / YiAi Comparative Example 3: A composition of acetate and bifenthrin was prepared as follows: Ingredients Quantity (w / w) Acetate 76.02 Bifenthrin 6.33 Metasperse 3.00 Soprophor-wp 2.00 PG-4000 6.50 Ammonium sulfate 5.80 Mfill A-1 00 0.35 Process: The weighed quantity of bifenthrin was mixed with Mf11 A-100 to form a bifenthrin premix. The bifenthrin premix was ground in an air jet mill to obtain the desired particle size. Then, the weighed quantities of acetate and other surfactants were added to the bifenthrin premix to obtain the bifenthrin-acephate premix. Next, the bifenthrin-acephate premix was extruded using the hot melt extrusion process in an axial extruder to obtain the granules. The granules thus obtained were then sieved to remove oversized and undersized particles. The final granules were subjected to quality specification testing and packaged. The physical parameters of a composition comprising acetate and imidacloprid according to comparative example 3 are indicated below Physicochemical properties Immediate dispersion after processing Good Inversion number 12 Dispersion after 3 days of aging after processing Poor Inversion number >30 pbapcn / Lzzza / YiAi Previous experimental results indicate that if conventional procedures are followed to prepare compositions comprising acetate, degradation of the acetate occurs and it cannot be stored for a longer period. Furthermore, it has been observed that compositions prepared according to conventional procedures require a significant investment when dispersing the formulation. The suspensibility of the compositions was also not within acceptable limits, rendering them unsuitable for the intended activity of the product.

Claims

1. A composition comprising: a) a phosphoramidothioate; and b) an electrolyte; characterized in that the composition is formulated using a mixture of water and the electrolyte.

2. The composition of claim 1 characterized in that the phosphoramidothioate is selected from the group comprising acetate, chloramine phosphorus, isocarbophos, isophenphos, isophenphos-methyl, methamidophos, phosglycine, or propetamphos.

3. The composition of claim 1 characterized in that the phosphoramidothioate is acetate.

4. The composition of claim 1 characterized in that the electrolyte is selected from an inorganic or organic salt.

5. The composition of claim 4 characterized in that the inorganic salt is selected from the group comprising salts of strong acids with strong bases, strong acids with weak bases, weak acids with strong bases, and weak acids with weak bases.

6. The composition of claim 4 characterized in that the inorganic salt is selected from the group comprising ammonium salts, alkali and alkaline earth metal salts, phosphates, carbonates, sulfates, nitrates, chlorides, oxides or hydroxides 7. A composition comprising: d) a phosphoramidothioate; e) an electrolyte; and f) one or more active ingredients; characterized in that the composition is formulated using a mixture of water and the electrolyte. pbapcn / Lznza / YiAi 8. The composition of claim 7 characterized in that phosphoramidothioate is acetate present as an active ingredient.

9. The composition of claim 7 characterized in that one or more active ingredients are selected from an organophosphorus compound, a chloronicotinyl compound, a diamide insecticide, a chitin synthesis inhibitor benzoylphenylurea, or a pyrethroid compound.

10. The composition of claim 7 characterized in that the composition comprises acetamiprid, imidacloprid, thiacloprid, thiamethoxam, cypermethrin, fenvalerate, permethrin, alpha-cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin, bioresmethrin, chlorantraniliprole, cyantraniliprole, cyclaniliprol, tetrachlorantraniliprole, lufenuron, novaluron or mixtures thereof.

11. The composition of claim 7 characterized in that the electrolyte is selected from an inorganic or organic salt.

12. A process for preparing a phosphoramidothioate composition resistant to degradation of the active ingredient, the process comprises: Step 1: preparing a mixture of water and an electrolyte; Step 2: preparing a combination of phosphoramidothioate, remaining electrolyte if any, and other excipients; Step 3: preparing an addition mixture of the combination from Step 2 with the mixture from Step 1; and Step 4: formulating into a suitable form using suitable equipment.

13. The process of claim 12 characterized in that the phosphoramidothioate active ingredient is acetate.

14. The process of claim 13, characterized in that the acetate degradation is controlled to less than 5 wt% acetate in the composition. rfrQQcni znz-i / YiAi 15. The process of claim 12 characterized in that the electrolyte is selected from an inorganic or organic salt.

16. A process for preparing a phosphoramidothioate composition resistant to degradation of the active ingredient; the process comprises: Step 1: preparing a mixture of water and an electrolyte; Step 2: preparing a combination of phosphoramidothioate, remaining electrolyte if any, and one or more other active ingredients; Step 3: preparing an addition mixture of the combination from Step 2 with the mixture from Step 1; and Step 4: formulating in a suitable form.

17. The process of claim 16 characterized in that one or more active ingredients are selected from an organophosphorus compound, a chloronicotinyl compound, a diamide insecticide, a chitin synthesis inhibitor benzoylphenylurea, or a pyrethroid compound.

18. A method for controlling insects, comprising applying to an area to be treated, an effective amount of a composition comprising: d) a phosphoramidothioate; e) an electrolyte; f) optionally one or more active ingredients; characterized in that the composition is formulated using a mixture of water and the electrolyte.

19. The method of claim 18 characterized in that phosphoramidothioate is present as an active ingredient.