SEIPIN mRNA-SPECIFIC, N-ACETYLGALACTOSAMINE (GaINAc) CONJUGATED OLIGONUCLEOTIDE SEQUENCE AND ITS APPLICATION AGAINST LIVER DISEASES

Abstract

The invention relates to the fields of biotechnology and molecular biology; specifically, to nucleic acid-based technologies. therapeutic agents, RNA interference (RNAi) technologies, oligonucleotides for gene silencing This relates to the design and targeted ligand conjugation of these ligands. More specifically... The invention, as described, provides hepatocyte-targeted gene silencing with N-acetylgalactosamine (GalNAc). conjugated, Seipin gene-specific oligonucleotide sequence (siSeipin) and abnormalities of this sequence It relates to its application in liver diseases associated with lipid accumulation.