Magnesium-containing degradable and injectable hydrogel bone repair material and preparation method therefor

Abstract

A magnesium-containing degradable and injectable hydrogel bone repair material and a preparation method therefor, which method comprises the following steps: preparing a magnesium-containing biodegradable scaffold using a biodegradable polymer, a biodegradable inorganic substance and a metal magnesium powder; mixing a calcium chloride solution and a calcium gluconate solution, adding the mixture into a sodium alginate powder, and stirring and mixing same to obtain a hydrogel fluid; and pulverizing the magnesium-containing biodegradable scaffold into magnesium-containing biodegradable particles with a particle size of 0.5-1.0 mm, adding same into the hydrogel fluid, and stirring to obtain a magnesium-containing degradable and injectable hydrogel bone repair material. The bone repair material is used in the repair of non-weight-bearing bone defects of limbs and alveolar bone defects, and the injection filling of bone defects caused by wounds, diseases, surgery, etc. The bone repair material can be shaped freely without cutting, and has the effects of stopping bleeding and promoting bone regeneration at a bone defect site. The running-in of the material and the defect wound can be reduced, and secondary contamination caused by adhesion of the material and the damaged tissue is prevented.

Description

A magnesium-containing degradable injectable hydrogel bone repair material and its preparation method Technical Field

[0001] The present invention relates to the technical field of bone repair, in particular to a magnesium-containing degradable injectable hydrogel bone repair material and a preparation method thereof. Background Art

[0002] With advancements in science and technology, medical expertise is constantly improving, and medical materials are gaining increasing attention. The use of artificial bone substitutes to repair and replace bone defects has become a key research focus in orthopedics. Significant progress has been made in the research of various materials and tissue-engineered bone, with different materials demonstrating robust bone defect repair capabilities. With the development of biomaterials science and technology, the performance and clinical effectiveness of synthetic bone repair materials are continuously improving. These products are gradually gaining recognition and acceptance among more and more clinicians, and are being used in the filling and regeneration of various bone defects in clinical practice.

[0003] The hydrogel skeleton is generally formed by polymer polymerization, and its interior is a three-dimensional network containing a large amount of water, which makes the entire gel skeleton have the characteristics of a fluid, which is similar to the structure of biological tissues filled with a large amount of water. Due to the local softness and wettability of the hydrogel and the biomimetic loose structure, it can significantly avoid irritation to biological tissues, thereby improving biocompatibility. Injectable hydrogels have been widely used in drug delivery and tissue repair engineering due to their unique physicochemical properties, such as unique hydrophilicity, water retention and biomimetic properties, good biocompatibility, special fluid dynamics properties, and multiple environmental responsiveness. Based on natural polymer materials, injectable polymer hydrogels are synthesized, and their structure and properties can be finely controlled to meet therapeutic needs. In particular, multifunctional responsive gels with controllable degradation, good biocompatibility, good reproducibility, easy processing and industrial production have great potential for clinical application.

[0004] In recent years, the commercialization of artificial bone materials has injected new vitality into biomedicine and tissue engineering medicine. However, artificial bone materials possess a certain mechanical strength. Implantation into bone defects often requires cutting the material and smoothing the irregular autologous bone to ensure complete implantation. This procedure is complex. Open fracture bone defects caused by trauma often lead to bone infection, necessitating the development of infection-resistant and more user-friendly bone repair materials for repairing bone defects.

[0005] Summary of the Invention

[0006] To address the deficiencies in the prior art, the present invention provides a magnesium-containing degradable injectable hydrogel bone repair material and a preparation method thereof. Biodegradable polymers, biodegradable inorganic substances, and metallic magnesium powder are prepared in a certain proportion using 3D printing technology under low-temperature conditions. An injectable hydrogel material composed of sodium alginate, calcium chloride, and calcium gluconate is used as a carrier to carry the magnesium-containing degradable bone repair material to achieve a degradable injectable hydrogel bone repair material composited with the hydrogel and degradable bone repair material. The material is effectively used for repairing non-load-bearing bone defects of the limbs and alveolar bone defects, and for injection filling of bone defects caused by trauma, disease, surgery, etc. It does not require cutting and can be shaped at will, and can also stop bleeding and promote bone regeneration at the bone defect site. It can address various problems existing in traditional artificial bone transplantation treatment methods, such as increasing blood volume and maintaining blood pressure, filling wounds with arbitrary shaping, reducing the running-in of the material and the defect wound, and preventing the adhesion of the material to the tissue at the damaged site and causing secondary contamination. The material expands the performance and applications of porous scaffold bone repair materials and gel composites, providing more options for clinical needs.

[0007] To achieve the above-mentioned purpose, the present invention is implemented through the following technical solutions:

[0008] A magnesium-containing degradable injectable hydrogel bone repair material, comprising the following components:

[0009] Biodegradable magnesium-containing particles, wherein the raw materials of the biodegradable magnesium-containing particles include: biodegradable polymers, biodegradable inorganic substances, and metallic magnesium powder;

[0010] The hydrogel fluid comprises raw materials including calcium chloride solution, calcium gluconate solution and sodium alginate powder.

[0011] A magnesium-containing degradable injectable hydrogel bone repair material, comprising the following components in parts by mass:

[0012] The magnesium-containing biodegradable particles are 40 to 66 parts, and the hydrogel fluid is 100 parts. Exemplarily, the magnesium-containing biodegradable particles are 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, and 66 parts.

[0013] The raw materials of the magnesium-containing biodegradable particles include, by weight, 50-85 parts of a biodegradable polymer, 10-35 parts of a biodegradable inorganic substance, and 2-20 parts of metallic magnesium powder; illustratively, 50 parts, 53 parts, 55 parts, 57 parts, 60 parts, 62 parts, 65 parts, 68 parts, 70 parts, 71 parts, 75 parts, 78 parts, 80 parts, 83 parts, and 85 parts of the biodegradable polymer; 10 parts, 12 parts, 15 parts, 17 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 31 parts, 32 parts, and 35 parts of the biodegradable inorganic substance; and 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, and 20 parts of metallic magnesium powder.

[0014] The raw materials of the hydrogel fluid include: 1-10 parts of calcium chloride solution, 10-25 parts of calcium gluconate solution, and 60-90 parts of sodium alginate powder. Exemplarily, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, and 10 parts of calcium chloride solution, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, and 25 parts of calcium gluconate solution, and 60 parts, 62 parts, 65 parts, 68 parts, 70 parts, 73 parts, 75 parts, 78 parts, 80 parts, 82 parts, 85 parts, 87 parts, and 90 parts of sodium alginate powder.

[0015] The particle size of the magnesium-containing biodegradable particles is 0.5 mm to 1.0 mm. Exemplarily, the particle size of the magnesium-containing biodegradable particles can be 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, or 0.9 mm, or the magnesium-containing biodegradable particles can be mixed particles of any particle size between 0.5 mm and 1.0 mm.

[0016] The biodegradable polymer is one or more of polyglycolic acid-lactic acid copolymer, polylactic acid, polyglycolic acid, polycaprolactone, polyorthoester, polyanhydride, polyphosphazene, and polyamino acid mixed in any proportion.

[0017] The biodegradable inorganic substance includes one or more of α-tricalcium phosphate, β-tricalcium phosphate, hydroxyapatite, calcium phosphate, and calcium silicate mixed in any proportion.

[0018] The raw materials of the magnesium-containing biodegradable particles further include 1 to 15 parts of doped metal powder in parts by mass. Exemplarily, the doped metal powder is 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, and 15 parts. The doped metal powder is one or more of copper, zinc, silver, iron, calcium, and titanium mixed in any proportion. Exemplarily, the doped metal powder is a combination of silver, zinc, and calcium; or a combination of zinc, silver, and iron; or a combination of zinc, silver, calcium, and titanium.

[0019] The magnesium-containing biodegradable particles are formed into a magnesium-containing biodegradable stent at a temperature of -180°C to -20°C using 3D printing technology, and then the magnesium-containing biodegradable stent is crushed to obtain the obtained product.

[0020] A method for preparing a magnesium-containing degradable injectable hydrogel bone repair material comprises the following steps:

[0021] Preparation of magnesium-containing biodegradable stent: a biodegradable polymer is dissolved in an organic solvent to form a biodegradable polymer solution; a biodegradable inorganic substance is added to the biodegradable polymer solution to form a homogeneous liquid, metallic magnesium powder is added to the homogeneous liquid, and stirred at room temperature for 5 to 30 hours to obtain a mixed solution. For example, the mixture is stirred at room temperature for 10 hours, 15 hours, 20 hours, and 25 hours; the mixed solution is 3D printed under low temperature conditions of -180°C to -20°C to form a magnesium-containing biodegradable stent blank. For example, the mixed solution can be 3D printed at -180°C, -170°C, -160°C, -150°C, -140°C, -130°C, -120°C, -110°C, -100°C, -90°C, etc. , -80℃, -70℃, -60℃, -50℃, -45℃, -40℃, -35℃, -30℃, -25℃, -20℃ low temperature conditions, 3D printing is used to form a magnesium-containing biodegradable stent blank; low-temperature rapid prototyping equipment can be used for 3D printing, and the molding working chamber of the equipment is pre-cooled to a temperature of -180℃~-20℃; the magnesium-containing biodegradable stent blank is frozen at a temperature of -180℃~-20℃ for 5~40 hours, and then vacuum-dried at a vacuum condition of 40℃~55℃ for 5~30 days to obtain a magnesium-containing biodegradable stent; illustratively, it is frozen at a temperature of -45℃ for 35 hours; and vacuum-dried at a vacuum condition of 45℃ for 25 days to obtain a magnesium-containing biodegradable stent.

[0022] Mixing calcium chloride solution and calcium gluconate solution, adding sodium alginate powder, and stirring to obtain a hydrogel fluid;

[0023] The magnesium-containing biodegradable scaffold is crushed into magnesium-containing biodegradable particles, which are then added into a hydrogel fluid and stirred at room temperature to obtain a magnesium-containing biodegradable injectable hydrogel bone repair material.

[0024] The preparation of the magnesium-containing biodegradable stent further comprises adding doped metal powder, wherein the doped metal powder and metallic magnesium powder are added together into a homogeneous liquid.

[0025] The organic solvent is at least one of 1,4-dioxane, acetonitrile, cyclohexane, acetone, ethylene glycol, cyclohexanone, and dichloromethane.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. The present invention combines biodegradable polymers / biodegradable inorganic substances / magnesium powder / hydrogel fluids into the same bone repair material to prepare a magnesium-containing biodegradable injectable hydrogel bone repair material, which can be directly injected and implanted into the bone defect site without further grinding the autologous bone at the bone defect site, thereby maximizing the integrity of the autologous bone. The lubrication and adhesion of the hydrogel reduce further damage caused by the running-in of the material and the defect.

[0028] 2. The magnesium-containing degradable injectable hydrogel bone repair material of the present invention has a certain adhesion before solidification, can fit well with the bone defect site and adhere to the autologous bone without falling off easily. After solidification, it sticks to the autologous bone and takes shape, which can greatly improve the fit between the material and the autologous bone defect site and promote bone formation and bone healing.

[0029] 3. The present invention uses 3D printing technology under low-temperature conditions to prepare a magnesium-containing biodegradable scaffold from a biodegradable polymer / biodegradable inorganic substance / magnesium powder and crush it. An injectable hydrogel material composed of sodium alginate, calcium chloride, and calcium gluconate is used as a carrier to carry magnesium-containing biodegradable polymer bone repair particles to achieve a bone repair material composited with the hydrogel and magnesium-containing biodegradable polymer bone repair particles. The magnesium-containing biodegradable injectable hydrogel bone repair material prepared in this way is effectively used for repairing non-load-bearing bone defects of the limbs and alveolar bone defects. It is used for injection filling of bone defects caused by trauma, disease, surgery, etc., can be shaped at will without cutting, stop bleeding, and promote bone regeneration at the bone defect site. It can solve various problems existing in traditional artificial bone transplantation treatment methods, such as increasing blood volume and maintaining blood pressure, filling wounds with free shaping, reducing the running-in of the material and the defect wound, and preventing the adhesion of the material to the tissue at the damaged site and causing secondary contamination. It can also expand the performance and applications of porous scaffold bone repair materials and gel composites, providing more options for clinical needs.

[0030] 4. The hydrogel fluid of the present invention comprises 1-10 parts of calcium chloride solution, 10-25 parts of calcium gluconate solution, and 60-90 parts of sodium alginate powder. The three components cooperate with the magnesium-containing biodegradable particles to alleviate the problem of inconvenience in injection caused by rapid solidification of the hydrogel in clinical practice, thereby saving time for surgery. The delay and indentation of the hydrogel coagulation time can provide a certain amount of remedial time for surgical patients in clinical applications to a certain extent, thereby achieving maximum utilization of the product. The addition of calcium gluconate can also supplement calcium ions, thereby promoting bone resorption and bone formation. Calcium gluconate also has anti-allergic effects; adding a certain concentration of calcium chloride to sodium alginate will make the gel brittle, which directly affects the tensile strength of the gel. Since the network structure on the surface of the gel is too dense, the incomplete calcium alginate inside the gel has low water holding capacity, so the absorption rate of the gel is reduced. The addition of calcium gluconate will improve the brittleness of the hydrogel after coagulation, make the internal network structure loose and increase the absorption rate of the gel; on the other hand, it can synergize with calcium chloride and replace the calcium element needed by the human body with sodium alginate to form a cross-linked gel system, increase bone density and treat osteoporosis. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] FIG1 is a physical diagram of the magnesium-containing biodegradable particles of the present invention having a particle size of 0.5 mm to 1.0 mm. DETAILED DESCRIPTION

[0032] The present invention will be further described with reference to specific embodiments. It should be understood that these embodiments are intended to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that, after reading the content of the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined in the present application.

[0033] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for the purpose of describing specific specific embodiments, rather than for the purpose of limiting the scope of protection of the present invention. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meanings as those commonly understood by those skilled in the art. The test methods for which specific conditions are not specified in the following examples are generally carried out under conventional conditions or under the conditions recommended by the manufacturers. In addition to the specific methods, equipment, and materials used in the examples, any methods, equipment, and materials of the prior art that are similar or equivalent to the methods, equipment, and materials described in the examples of the present invention may also be used to implement the present invention, based on the prior art mastery of those skilled in the art and the description of the present invention.

[0034] Example 1

[0035] A magnesium-containing degradable injectable hydrogel bone repair material, comprising the following components in parts by mass:

[0036] The magnesium-containing biodegradable particles are 45 parts, and the hydrogel fluid is 100 parts. The raw materials for the magnesium-containing biodegradable particles, calculated by weight, include: 55 parts of a biodegradable polymer, 20 parts of a biodegradable inorganic substance, and 10 parts of metallic magnesium powder. The raw materials for the hydrogel fluid include: 5 parts of a calcium chloride solution (5% by weight), 15 parts of a calcium gluconate solution (25% by weight), and 70 parts of sodium alginate powder. The biodegradable polymer is poly(lactic-co-glycolic acid) (PLGA), and the biodegradable inorganic substance is β-tricalcium phosphate (β-TCP).

[0037] A method for preparing a magnesium-containing degradable injectable hydrogel bone repair material comprises the following steps:

[0038] Preparation of a magnesium-containing biodegradable stent: A biodegradable polymer is dissolved in an organic solvent, wherein the organic solvent is 1,4-dioxane, to form a biodegradable polymer solution; a biodegradable inorganic substance is added to the biodegradable polymer solution and stirred to form a homogeneous liquid, and metallic magnesium powder is added to the homogeneous liquid and stirred at room temperature for 10 hours to obtain a mixed solution; the biodegradable inorganic substance is crushed and the metallic magnesium powder is passed through a 200-400 mesh sieve before use, and the mixed solution is 3D printed at a low temperature of -50°C using a low-temperature rapid prototyping equipment to form a magnesium-containing biodegradable stent blank, and the molding working chamber of the low-temperature rapid prototyping equipment is pre-cooled to -50°C; the magnesium-containing biodegradable stent blank is frozen at -45°C for 35 hours and vacuum dried at 45°C for 25 days to obtain a magnesium-containing biodegradable stent.

[0039] Mixing calcium chloride solution and calcium gluconate solution, adding sodium alginate powder, and stirring to obtain a hydrogel fluid;

[0040] The magnesium-containing biodegradable scaffold is crushed into magnesium-containing biodegradable particles, which are then added into a hydrogel fluid and stirred at room temperature to obtain a magnesium-containing biodegradable injectable hydrogel bone repair material.

[0041] Example 2

[0042] A magnesium-containing biodegradable injectable hydrogel bone repair material comprises the following components, measured by weight: 45 parts of magnesium-containing biodegradable particles and 100 parts of a hydrogel fluid. The raw materials for the magnesium-containing biodegradable particles, measured by weight, include: 62 parts of a biodegradable polymer, 15 parts of a biodegradable inorganic substance, and 12 parts of metallic magnesium powder. The raw materials for the hydrogel fluid include: 5 parts of a calcium chloride solution (5% by weight), 15 parts of a calcium gluconate solution (25% by weight), and 70 parts of sodium alginate powder. The biodegradable polymer is poly(lactic-co-glycolic acid) (PLGA), and the biodegradable inorganic substance is β-tricalcium phosphate (β-TCP).

[0043] The preparation method is consistent with that in Example 1.

[0044] Example 3

[0045] A magnesium-containing biodegradable injectable hydrogel bone repair material comprises the following components, measured by weight: 45 parts of magnesium-containing biodegradable particles and 100 parts of a hydrogel fluid. The raw materials for the magnesium-containing biodegradable particles, measured by weight, include: 78 parts of a biodegradable polymer, 18 parts of a biodegradable inorganic substance, and 8 parts of metallic magnesium powder. The raw materials for the hydrogel fluid include: 5 parts of a calcium chloride solution (5% by weight), 20 parts of a calcium gluconate solution (25% by weight), and 80 parts of sodium alginate powder. The biodegradable polymer is poly(lactic-co-glycolic acid) (PLGA), and the biodegradable inorganic substance is β-tricalcium phosphate (β-TCP).

[0046] The preparation method is consistent with that in Example 1.

[0047] Example 4

[0048] A magnesium-containing biodegradable injectable hydrogel bone repair material comprises the following components, measured by weight: 45 parts of magnesium-containing biodegradable particles and 100 parts of a hydrogel fluid. The raw materials for the magnesium-containing biodegradable particles, measured by weight, include: 78 parts of a biodegradable polymer, 18 parts of a biodegradable inorganic substance, and 12 parts of metallic magnesium powder. The raw materials for the hydrogel fluid include: 10 parts of a calcium chloride solution (5% by weight), 15 parts of a calcium gluconate solution (25% by weight), and 60 parts of sodium alginate powder. The biodegradable polymer is poly(lactic-co-glycolic acid) (PLGA), and the biodegradable inorganic substance is β-tricalcium phosphate (β-TCP).

[0049] The preparation method is consistent with that in Example 1.

[0050] Example 5

[0051] A magnesium-containing degradable injectable hydrogel bone repair material differs from Example 4 in that it also includes doped metal powders, including 5 parts of silver, 3 parts of zinc, and 3 parts of calcium.

[0052] Example 6

[0053] A magnesium-containing degradable injectable hydrogel bone repair material is different from Example 4 in that the biodegradable polymer is polyamino acid and the biodegradable inorganic substance is α-tricalcium phosphate.

Claims

1. A magnesium-containing degradable injectable hydrogel bone repair material, characterized in that: Includes the following components: Biodegradable magnesium-containing particles, the raw materials of which include: biodegradable polymers, biodegradable inorganic substances, and metal magnesium powder; The hydrogel fluid comprises raw materials of calcium chloride solution, calcium gluconate solution and sodium alginate powder.

2. The magnesium-containing degradable injectable hydrogel bone repair material according to claim 1, characterized in that: According to the mass percentage, it includes the following components: 40-66 parts of the magnesium-containing biodegradable particles and 100 parts of the hydrogel fluid; The raw materials of the magnesium-containing biodegradable particles include, by weight, 50 to 85 parts of biodegradable polymer, 10 to 35 parts of biodegradable inorganic matter, and 2 to 20 parts of metal magnesium powder; The raw materials of the hydrogel fluid include, by weight, 1 to 10 parts of calcium chloride solution, 10 to 25 parts of calcium gluconate solution, and 60 to 90 parts of sodium alginate powder.

3. The magnesium-containing degradable injectable hydrogel bone repair material according to claim 1, characterized in that: The particle size of the magnesium-containing biodegradable particles is 0.5 mm to 1.0 mm.

4. The magnesium-containing degradable injectable hydrogel bone repair material according to claim 1, characterized in that: The biodegradable polymer is one or more of polyglycolic acid-lactic acid copolymer, polylactic acid, polyglycolic acid, polycaprolactone, polyorthoester, polyanhydride, polyphosphazene and polyamino acid mixed in any proportion.

5. The magnesium-containing degradable injectable hydrogel bone repair material according to claim 1, characterized in that: The biodegradable inorganic substance includes one or more of α-tricalcium phosphate, β-tricalcium phosphate, hydroxyapatite, calcium phosphate, and calcium silicate mixed in any proportion.

6. The magnesium-containing degradable injectable hydrogel bone repair material according to claim 1, characterized in that: The raw material of the magnesium-containing biodegradable particles further includes 1 to 15 parts of doped metal powder by weight, wherein the doped metal powder is one or more of copper, zinc, silver, iron, calcium and titanium mixed in any proportion.

7. The magnesium-containing degradable injectable hydrogel bone repair material according to claim 1, characterized in that: The magnesium-containing biodegradable particles are formed into a magnesium-containing biodegradable stent at a temperature of -180°C to -20°C by using 3D printing technology, and then the magnesium-containing biodegradable stent is crushed to obtain the stent.

8. The method for preparing a magnesium-containing degradable injectable hydrogel bone repair material according to any one of claims 1 to 7, characterized in that: The following steps are involved: Preparation of magnesium-containing biodegradable stent: a biodegradable polymer is dissolved in an organic solvent to form a biodegradable polymer solution; a biodegradable inorganic substance is added to the biodegradable polymer solution to form a homogeneous liquid, and metal magnesium powder is added to the homogeneous liquid, and stirred at room temperature for 5 to 30 hours to obtain a mixed liquid; the mixed liquid is formed into a magnesium-containing biodegradable stent blank by 3D printing under a low temperature condition of -180°C to -20°C; the magnesium-containing biodegradable stent blank is frozen at a temperature of -180°C to -20°C for 5 to 40 hours, and then vacuum dried at a vacuum condition of 40°C to 55°C for 5 to 30 days to obtain a magnesium-containing biodegradable stent; Mixing the calcium chloride solution and the calcium gluconate solution, adding the sodium alginate powder, and stirring and mixing to obtain a hydrogel fluid; The magnesium-containing biodegradable stent is crushed into magnesium-containing biodegradable particles, which are then added into a hydrogel fluid and stirred at room temperature to obtain a magnesium-containing biodegradable injectable hydrogel bone repair material.

9. The method for preparing a magnesium-containing degradable injectable hydrogel bone repair material according to claim 8, characterized in that: The preparation of the magnesium-containing biodegradable stent further comprises adding doped metal powder, wherein the doped metal powder is added into a homogeneous liquid together with metal magnesium powder.

10. The method for preparing a magnesium-containing degradable injectable hydrogel bone repair material according to claim 8, characterized in that: The organic solvent is at least one of 1,4-dioxane, acetonitrile, cyclohexane, acetone, ethylene glycol, cyclohexanone and dichloromethane.

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