Cell-accommodating dish and kit for administering cells

Abstract

Provided is a cell-accommodating dish from which accommodated cells or cell clusters are easily sucked out and recovered by a cannula. This cell-accommodating dish has, in a body thereof, at least one first cell-accommodating part that is capable of accommodating a liquid including cells or cell clusters, and that has a recessed shape which is open on the top surface side of the body and which has a long direction and a short direction. The first cell-accommodating part has a straight section that linearly extends in the long direction longer than the length in the short direction, and further has inclined surfaces that are downwardly inclined from both ends of the opening in the short direction in the straight section toward the bottom of the recessed shape so as to approach each other.

Description

Cell storage dishes and cell administration kits

[0001] The present invention relates to a cell-containing dish and a cell administration kit including the cell-containing dish.

[0002] When administering cells or cell clusters (e.g., cell sheets, etc.) to a living organism, a method may be employed in which the cells or cell clusters stored in a microtube or the like are removed and temporarily placed in a container, the cells or cell clusters are transferred from this container to a tubular cannula or the like, and the cells or cell clusters are administered to the living organism through this cannula, etc. For example, Patent Document 1 discloses a method for treating a medical, aesthetic, or veterinary condition in a subject, which includes administering cells from a predetermined container containing cells to the subject through a cannula.

[0003] Japanese Patent Application Laid-Open No. 2021-106591

[0004] However, when a dish of a typical shape (such as a round dish) is used as a container to temporarily store cells or cell clusters, when cells or cell clusters are sucked from this dish into a tubular cannula to be recovered, it can be difficult to suck the cells or cell clusters from the dish into the cannula, or it can be impossible to suck and recover all of the cells or cell clusters in the dish.

[0005] The present invention has been made in view of the above problems, and has as its object to provide a cell-containing dish that allows contained cells or cell clusters to be easily aspirated and recovered using a cannula.

[0006] The cell storage dish of the present invention is characterized in that its main body is provided with one or more first cell storage sections, which are concave in shape and have longitudinal and lateral directions and open on the upper surface side of the main body, and which can store a liquid containing cells or cell aggregates; each first cell storage section has a straight section in its longitudinal direction that extends linearly for a length longer than its lateral length; and each straight section has inclined surfaces that slope downward from both ends of the lateral opening of the straight section toward the bottom side of the concave shape so as to approach each other.

[0007] Furthermore, the cell administration kit according to the present invention is characterized by comprising the cell storage dish according to the present invention described above, and a cannula, which is a tubular structure made of a resin material and has an approximately elliptical opening that can suck cells or cell clusters into its interior from the first cell storage portion of the cell storage dish according to the present invention.

[0008] According to the present invention, it is possible to provide a cell storage dish that allows stored cells or cell clusters to be easily aspirated and recovered using a cannula, as well as a cell administration kit that includes this cell storage dish and a cannula.

[0009] 1. A perspective view from the top side of a cell-containing dish according to this embodiment. A perspective view from the back side (bottom side) of a cell-containing dish according to this embodiment. A cross-sectional view of a cell-containing dish according to this embodiment taken along line III-III in FIG. 1. A front view from the top side of a cell-containing dish according to this embodiment. A perspective view schematically showing a state in which cells or cell clumps are aspirated and collected from a first cell-containing section of a cell-containing dish according to this embodiment using a cannula provided in a cell administration kit according to this embodiment. An enlarged view of a cannula provided in a cell administration kit according to this embodiment. A cross-sectional view of a state in which cell clumps and a cannula are arranged in a first cell-containing section of a cell-containing dish according to this embodiment. A cross-sectional view of a state in which cell clumps and a cannula are arranged in a modified first cell-containing section of a cell-containing dish according to this embodiment. A cross-sectional view of a state in which cell clumps and a cannula are arranged in another modified first cell-containing section of a cell-containing dish according to this embodiment.

[0010] Hereinafter, embodiments of the cell-containing dish and cell administration kit according to the present invention will be described with reference to the drawings. The embodiments described below are merely examples intended to facilitate understanding of the present invention and are not intended to limit the present invention. In other words, the shapes, dimensions, arrangements, etc. of the components described below may be modified or improved without departing from the spirit of the present invention, and the present invention naturally includes equivalents. Furthermore, similar components are designated by similar reference numerals in all drawings, and redundant descriptions are omitted where appropriate. For convenience, some parts in each drawing are not designated (omitted) by reference numerals. Furthermore, the dimensional proportions of the components shown in the drawings may differ from the actual dimensional proportions in order to facilitate understanding of the invention.

[0011] <Cell-holding dish> First, the configuration of the cell-holding dish 100 according to this embodiment will be described with reference to Figs. 1 to 5. Figs. 1 and 2 are perspective views that schematically show the entire cell-holding dish 100 according to this embodiment. Fig. 3 is a cross-sectional view that schematically shows a cross section including the first cell-holding section 21 and the second cell-holding section 22 of the cell-holding dish 100 according to this embodiment. Fig. 4 is a front view from above that schematically shows the entire cell-holding dish 100 according to this embodiment. Furthermore, Fig. 5 is a perspective view that schematically shows the entire cell-holding dish 100 according to this embodiment and a portion of the cannula 70 used therein.

[0012] The cell-containing dish 100 according to this embodiment is used to contain cells or cell clumps 80. The cell-containing dish 100 includes a main body 10 having one or more first cell-containing sections 21, each having a longitudinal and lateral recessed shape and opening on the upper surface (main body upper surface 11) of the main body 10, capable of containing a liquid containing cells or cell clumps 80. The first cell-containing section 21 includes a straight section 31 extending linearly in the longitudinal direction that is longer than its lateral length. The straight section 31 also includes inclined surfaces that slope downward from both ends of the lateral opening of the straight section 31 toward the bottom of the recessed shape, so as to approach each other. In other words, the cell-containing dish 100 according to this embodiment includes at least the main body 10, which serves as the main body, and includes one or more first cell-containing sections 21, each having a longitudinal and lateral recessed shape and opening on the upper surface. The main body 10 may further include a second cell-containing section 22, a waste liquid containing section 25, and the like, which will be described later. Hereinafter, each of the components provided in the main body 10 and other components will be described in detail.

[0013] (First Cell Containment Section) As described above, the main body 10 of the cell containment dish 100 according to this embodiment is provided with one or more first cell containment sections 21 capable of containing a liquid containing cells or cell aggregates 80. The first cell containment section 21 is a concave-shaped structure having longitudinal and lateral dimensions that opens on the upper surface side (main body upper surface 11 side) of the main body 10, and has a straight section 31 in the longitudinal direction that extends linearly longer than the lateral length. In other words, the longitudinal length of the straight section 31, which is the region in which the concave shape extends linearly, is longer than the lateral length of the first cell containment section 21. Note that the first cell containment section 21 is a concave-shaped structure having longitudinal and lateral dimensions; therefore, this does not include concave-shaped structures that have substantially no longitudinal or lateral dimensions, such as a concave-shaped opening with a circular or square opening. Furthermore, this first cell storage section 21 has at least inclined surfaces 33 that slope downward so as to approach each other from both ends of the opening in the shorter direction of the concave shape of the straight section 31 toward the bottom side of the concave shape. Because the first cell storage section 21 is configured in this manner, the cells or cell clumps 80 (e.g., multiple cells or cell clumps 80) stored in this first cell storage section 21 tend to gather near the bottom side of the straight section 31 that extends linearly in the longitudinal direction, that is, the cells or cell clumps 80 tend to gather near the bottom side of the straight section 31 in a state where they are generally lined up in the longitudinal direction, which makes it easier to suction and collect the cells or cell clumps 80 from the first cell storage section 21 using a cannula.

[0014] 1 and 2, an embodiment is exemplified in which the main body 10 of the cell storage dish 100 is provided with a first cell storage section 21 having a horizontally elongated concave structure opening on the main body upper surface 11, a straight section 31 in which the concave shape extends linearly in the longitudinal direction for a length longer than the length in the lateral direction, and inclined surfaces 33 (a pair of inclined surfaces 33 in the straight section 31) that are inclined toward each other from both ends of the opening in the lateral direction of the straight section 31 toward the bottom side of the concave shape. Note that in the embodiment of FIGS. 1 and 2, the straight section 31 is disposed so as to occupy 75% or more of the longitudinal length of the first cell storage section 21, and both ends of the longitudinal opening of the first cell storage section 21 are formed to be approximately semicircular. Furthermore, the straight portion 31 may have, for example, a cross section in the short direction that is a concave shape that is approximately V-shaped, or a cross section that is approximately an inverted trapezoid, or may have a cross section that is a concave shape having a bottom surface portion that is curved toward the bottom side (the bottom surface portion is rounded).

[0015] More preferably, the first cell storage section 21 has a flat surface 35 formed flat on the bottom side of the concave shape of the straight section 31, as shown in FIGS. 1 to 5 , that is continuous with the inclined surface 33 and extends linearly in the longitudinal direction. This flat surface 35 is generally parallel (substantially parallel) to the upper surface 11 of the main body. With this configuration, the cells or cell clumps 80 stored in the first cell storage section 21 tend to gather in a generally aligned state near this flat surface 35, and by using the cannula 70 along the flat surface 35 as shown in FIG. 5 , the cells or cell clumps 80 can be more easily sucked and collected. Furthermore, it is more preferable that the flat surface 35 extend over substantially the entire longitudinal direction on the bottom side of the concave shape of the straight section 31, since this more easily achieves the above-mentioned effect. In other words, it is even more preferable that the flat surface 35 extend over substantially the entire longitudinal direction of the straight section 31. Furthermore, this flat surface 35 may be positioned so that the cross section in the short direction of the straight portion 31 is an inverted trapezoidal concave shape that is approximately symmetrical left and right, or it may be positioned so that the bottom of this cross section is in an offset position (the bottom of this cross section is not in an approximately symmetrical position but is closer to one end of the straight portion 31 in the short direction) to form an inverted trapezoidal concave shape.

[0016] Furthermore, from the viewpoint of the ease of collection of the cells or cell clusters 80 contained in the first cell storage section 21, it is preferable that the length of the short side of the flat surface 35 is designed so that the contained cells or cell clusters 80 can be easily collected in a state where they are aligned in a substantially single row along their longitudinal direction. In order for the contained cells or cell clusters 80 to be collected in a substantially single row, it is preferable that the length of the short side of the flat surface 35 does not exceed (is not more than twice the length of) the diameter of the contained cells or cell clusters 80. In one aspect, the length of the short side of the flat surface 35 is preferably about 0.1 mm or more and 1.6 mm or less, more preferably about 0.1 mm or more and 1.0 mm or less, and even more preferably about 0.2 mm or more and 0.7 mm or less.

[0017] Furthermore, it is more preferable that the first cell storage section 21 be configured so that the inclined surfaces 33 (a pair of inclined surfaces 33) in the straight section 31 are continuous, and that the inclined surfaces 33 slope downward from the open end of the area other than the straight section 31 toward the bottom of the concave shape. In other words, it is more preferable that the first cell storage section 21 be configured so that the inclined surfaces 33 slope downward from the entire open end of the first cell storage section 21 toward the bottom of the concave shape, forming a continuous inclined surface 33. This is because the cells or cell clumps 80 stored in the first cell storage section 21 tend to gather near the bottom of the concave shape of the straight section 31. In particular, as in the embodiment shown in Figures 1 and 2, if the flat surface 35 described above is provided on the bottom side of the concave shape of the straight section 31, and the inclined surfaces 33 slope downward from the entire open end of the first cell storage section 21 toward this flat surface 35 so as to approach each other, forming a continuous inclined surface, the cells or cell clumps 80 tend to gather near this flat surface 35, making it even easier to suction and collect the cells or cell clumps 80 using the cannula 70.

[0018] Furthermore, the inclined surface 33 of the straight portion 31 in the first cell storage section 21 is preferably configured to slope downward at both ends of the short-side opening of the straight portion 31 so that the angle θ1 formed with the upper surface (main body upper surface 11) of the main body section 10 is preferably 10° or more, more preferably 15° or more, even more preferably 20° or more, and preferably 35° or less, more preferably 30° or less, and even more preferably 25° or less. This is because when the opening 71 of the cannula 70 is aligned along the length of the straight portion 31 so that a portion of the cannula 70 contacts the bottom of the straight portion 31, the gap between the cannula 70 and the bottom of the first cell storage section 21 becomes smaller, making it easier for the cannula 70 to suck in the cells or cell aggregates 80. For example, the angle θ1 is preferably sloped downward so that it is 10° or more and 35° or less, more preferably 15° or more and 30° or less, even more preferably 20° or more and 25° or less. The same applies to the configuration having the flat surface 35.

[0019] Note that this angle θ1 refers to the angle of the portion shown in Fig. 3. Specifically, in Fig. 3, the imaginary main body upper surface 11 at the opening portion of first cell storage section 21 is shown by a dashed dotted line, and angle θ1 is the angle formed between this imaginary main body upper surface 11 and inclined surface 33 of first cell storage section 21 at both ends of the opening in the short direction of straight section 31.

[0020] Furthermore, the first cell storage section 21 is a concave-shaped structure that opens on the upper surface of the main body 10 and has longitudinal and lateral dimensions. As long as it has the straight section 31 and the inclined surface 33 described above, various modifications other than those described above are possible. For example, it may be an embodiment in which the opening on the upper surface of the main body 10 is substantially rectangular in shape having longitudinal and lateral dimensions (an embodiment in which the entire section is a straight section 31), or an embodiment in which, in addition to the straight section 31, the opening and the concave shape also have a bent or curved region. Furthermore, it may be a configuration in which the bottom of the straight section 31 is inclined from one end to the other in the longitudinal direction (the bottom of the straight section 31 is inclined upward (downward) in the longitudinal direction), a configuration in which the opening width in the lateral direction of the straight section 31 gradually narrows from one end to the other in the longitudinal direction, or a configuration in which the bottom of the straight section 31 is inclined upward in the longitudinal direction as described above, and the opening width gradually narrows in the direction in which the bottom is inclined upward as described above. Furthermore, when the main body 10 is configured to have two or more first cell storage sections 21, these first cell storage sections 21 may be configured to differ from one another in the angle θ1 described above, the length of the short side of the straight section 31, etc. Furthermore, the straight section 31 is not limited to being a completely straight section, and may be a slightly curved shape within the plane of the main body 10 as long as it is a substantially straight (approximately straight) shape. In other words, the above-mentioned "extending linearly" also includes an embodiment in which it extends in a substantially straight (approximately straight) shape.

[0021] (Second Cell Storage Section) In addition to the first cell storage section 21 described above, the main body 10 of the cell storage dish 100 according to this embodiment preferably further includes one or more second cell storage sections 22, each of which is substantially conical and concave, and which open to the top of the main body 10 and has a continuous inclined surface 43 that slopes downward from the open end toward the bottom, and which can store a liquid containing cells or cell clumps 80. By using the second cell storage section 22, in which cells or cell clumps 80 tend to gather at a single point (near the deepest portion 45), in combination with the first cell storage section 21, it becomes easier to aspirate and recover all of the cells or cell clumps 80 in the liquid using the cannula 70. Furthermore, when using a syringe or the like to aspirate and recover cells or cell clumps 80 in the liquid, it is preferable to provide the second cell storage section 22 in addition to the first cell storage section 21. It is also possible to use this second cell storage section 22 or the like and to aspirate and recover cells or cell aggregates 80 using a syringe or the like instead of the cannula 70 .

[0022] For example, as shown in Figures 1 and 2, an embodiment is exemplified in which the second cell storage section 22 provided in the main body section 10 has a substantially conical recessed shape with a tapered diameter from its opening end toward the deepest part 45. Note that this substantially conical recessed shape includes not only a perfect conical recessed shape, but also a structure that is substantially conical, such as a structure having a slight flat surface at the deepest part 45. Furthermore, the opening is not limited to a perfect circle, but may be substantially circular. When there is a slight flat surface at the deepest part 45, the area of ​​the small flat surface is, although not limited to, 0.3 mm 2 More than 10 mm 2 It is preferable that:

[0023] Furthermore, it is more preferable that the depth of the deepest region of the second cell storage section 22 from the top surface (main body top surface 11) of the main body 10, i.e., the depth to the deepest portion 45, is deeper than the depth of the deepest region of the first cell storage section 21 from the top surface (main body top surface 11) of the main body 10. In particular, it is even more preferable that the deepest region of the first cell storage section 21 from the top surface of the main body 10 is included in the straight portion 31, and the depth to the deepest portion 45 of the second cell storage section 22 is deeper than this. This is because, for example, by using a deeper second cell storage section 22 in combination, it becomes easier to aspirate and recover all of the cells or cell clumps 80 in the liquid using a cannula 70 or the like. Here, the depth of the deepest region of the second cell storage section 22 from the top surface of the main body 10 refers to D2 in the embodiment of FIG. 3, and the depth of the deepest region of the first cell storage section 21 from the top surface of the main body 10 refers to D1 in the embodiment of FIG. 3.

[0024] Furthermore, it is even more preferable that the inclined surface 43 of the second cell storage section 22 is configured to slope downward at its open end so that the angle θ2 formed with the upper surface of the main body section 10 (main body upper surface 11) is preferably 10° or more, more preferably 15° or more, more preferably 20° or more, more preferably 25° or more, and even more preferably 30° or more, and preferably 40° or less, more preferably 35° or less. This is because the cells or cell aggregates 80 tend to gather at one point and the ease of suction and recovery by the cannula 70 is also maintained. For example, it is preferable that this angle θ2 slope downward so that it is 10° or more and 40° or less.

[0025] Note that this angle θ2 also refers to the angle of the portion shown in Fig. 3. Specifically, in Fig. 3, the imaginary main body upper surface 11 at the opening portion of the second cell storage section 22 is also shown by a dashed line, and the angle θ2 is the angle between this imaginary main body upper surface 11 and the inclined surface 43 of the second cell storage section 22 at the opening end.

[0026] Furthermore, it is more preferable that the angle θ2 formed by the inclined surface 43 of the second cell storage section 22 with the upper surface of the main body section 10 described above is greater than the angle θ1 formed by the inclined surface 33 of the straight section 31 in the first cell storage section 21 with the upper surface of the main body section 10, i.e., θ2 > θ1. By using the second cell storage section 22, which has a greater inclination than the straight section 31 of the first cell storage section 21, in combination, cells or cell clumps 80 in the liquid that were not completely aspirated and recovered from the first cell storage section 21 can be collected near the deepest section 45 of the second cell storage section 22, making it easier to aspirate and recover them.

[0027] Furthermore, in an embodiment including this second cell storage section 22, it is preferable that, in the longitudinal direction (longitudinal direction of the straight section 31) of the first cell storage section 21 (on the main body upper surface 11 side) on the upper surface of the main body section 10, the deepest region of the second cell storage section 22 from the main body upper surface 11, i.e., the position (position in the longitudinal direction) of the deepest part 45, is located at the same position as either end of the longitudinal direction of the straight section 31 of the first cell storage section 21. This is because the same position makes it easier (minimizes) to transfer a liquid containing cells or cell clumps 80 between the first cell storage section 21 and the second cell storage section 22 and to move the cannula 70. In other words, the effects of using these in combination are more easily realized.

[0028] For example, as shown in Figure 4, an embodiment is exemplified in which the position of the deepest part 45 of the second cell storage section 22 is the same as the position of one end of the straight section 31 of the first cell storage section 21 in the longitudinal direction of the first cell storage section 21 on the main body upper surface 11 side (the position of dotted line A in Figure 4). Here, "same position" includes not only an embodiment in which the deepest part 45 of the second cell storage section 22 and the end of the straight section 31 of the first cell storage section 21 are exactly in the same position in the longitudinal direction, but also an embodiment in which they are substantially in the same position.

[0029] Furthermore, in this embodiment, if the position of one end of the opening of the second cell storage section 22 (one of the opening ends in the longitudinal direction) is the same as the position of either one of the opening ends of the first cell storage section 21 (either of the opening ends in the longitudinal direction) in the longitudinal direction of the first cell storage section 21 on the upper surface of the main body 10, this makes it easier to transfer a liquid containing cells or cell clumps 80 from the first cell storage section 21 to the second cell storage section 22 and to move the cannula 70, and it is also very advantageous because it reduces the risk of leakage of the cells or cell clumps 80 or liquid outside the storage section during movement. For example, as shown in FIG. 4 , an embodiment is exemplified in which the position of one of the opening ends of the second cell storage section 22 and the position of one of the opening ends of the first cell storage section 21 are the same (the position of dotted line B in FIG. 4 ) in the longitudinal direction of the first cell storage section 21 on the main body upper surface 11 side. This "same position" encompasses not only embodiments in which the positions are exactly the same, but also embodiments in which the positions are substantially the same.

[0030] Note that this second cell storage section 22 can also be modified in various ways other than the above, as long as it is a generally conical recess that opens to the top surface of the main body 10 and has a continuous inclined surface 43 that slopes downward so as to approach each other from the opening end toward the bottom. Furthermore, when the main body 10 is configured to have two or more second cell storage sections 22, these multiple second cell storage sections 22 may be configured to differ from each other in the angle θ2 described above, the depth to the deepest part 45, the size of the opening, the presence or absence of a flat surface, etc.

[0031] (Waste Liquid Storage Section) In addition to the first cell storage section 21 described above, the main body section 10 of the cell storage dish 100 according to this embodiment is more preferably configured to further include one or more recessed waste liquid storage sections 25 opening on the upper surface of the main body section 10, which can store waste liquid (unwanted liquid) separated from the liquid containing the cells or cell clumps 80. Furthermore, an embodiment is even more preferable in which the main body section 10 includes one or more first cell storage sections 21, second cell storage sections 22, and waste liquid storage sections 25. This is because by separating a portion of excess liquid from the liquid containing the cells or cell clumps 80 stored in the first cell storage section 21 or the like and disposing of the liquid in the waste liquid storage section 25, it becomes easier to aspirate and collect the cells or cell clumps 80 using the cannula 70.

[0032] This waste liquid storage section 25 is not particularly limited as long as it is configured to be able to store waste liquid separated from a liquid containing cells or cell clumps 80, that is, has a concave shape that opens on the upper surface side of the main body section 10, but an example embodiment is one in which the opening on the upper surface side of the main body section 10 is approximately rectangular in shape with longitudinal and lateral directions, and further has a flat surface on the bottom side, as shown in Figures 1 and 2.

[0033] The main body 10 including these components may be made of a material other than a resin material (e.g., glass), but is preferably made of a resin material. For example, it can be manufactured by injection molding or vacuum forming using a resin material as the raw material. Here, "made of a resin material" means that the resin material is contained as the main material (the resin material constitutes 70% by mass or more of the total mass of the component, more preferably 80% by mass or more, and even more preferably 90% by mass or more), and may also contain a portion of materials other than the resin material, such as additives. The same applies hereinafter.

[0034] Examples of resin materials that can be used include polyolefin resins or cyclic polyolefin resins such as polypropylene, polyethylene, polymethylpentene, and ethylene-propylene copolymer; polystyrene resins such as polystyrene and acrylonitrile-butadiene-styrene; polyacrylic resins such as polyethylene terephthalate and polybutylene terephthalate; methacrylic resins such as polymethyl methacrylate; fluorine-based resins such as polytetrafluoroethylene; cellulose-based resins such as propionate resin; polyacrylonitrile resin; polycarbonate resin; vinyl chloride resin; polyvinylidene chloride resin; polyarylate resin; polysulfone resin; polyethersulfone resin; polyetheretherketone resin; and polyetherimide resin. These may be used alone or in combination of two or more. In particular, from the standpoint of manufacturability and suitability as a cell-containing dish, polyolefin resins or polystyrene resins are more preferred.

[0035] The main body 10 made of a resin material is not particularly limited, but preferably has a colorless, white, or milky white color, and a transparency (light transmittance) of transparent or translucent. For example, it may be colorless and transparent, white translucent, milky translucent, white opaque, or milky opaque. From the perspective of making the cells or cell aggregates 80 in the liquid easier to see and handle, the main body 10 is more preferably translucent or transparent. It is particularly preferred that the main body 10 made of this resin material be transparent, i.e., highly transparent. The color of the main body 10 is not particularly limited as long as it has high transparency, but in one embodiment, the main body 10 made of this resin material is preferably colorless and transparent. Here, "high transparency (transparent)" in this embodiment means that the total light transmittance measured in accordance with JIS K 7375:2008 is 70% or more, preferably 80% or more, and more preferably 90% or more. Therefore, the main body 10 made of a resin material preferably has a total light transmittance of 70% or more, more preferably 80% or more, and even more preferably 90% or more, as measured in accordance with JIS K 7375: 2008. On the other hand, "semi-transparent" means that the total light transmittance is 50% or more and less than 70%.

[0036] Furthermore, for ease of viewing and handling, in one embodiment, the cell-containing dish 100 according to the present embodiment is preferably placed on a dark-colored mounting surface. If the mounting surface is not dark, a dark-colored sheet-like object can be placed between the main body 10 and the mounting surface. Alternatively, a cell-containing dish 100 with a dark-colored sheet-like object on the bottom of the main body 10 can also be used. Depending on the color of the mounting platform, the operator can select a cell-containing dish 100 that allows for easy viewing of the cells or cell aggregates 80 from among those with a dark-colored sheet-like object on the bottom of the main body 10 and those without. The material of the sheet-like object is not particularly limited as long as the surface is dark-colored, but it can include paper, fiber (including nonwoven fabrics or nonwoven polypropylene fiber such as surgical drapes), resin, metal, wood, or rubber, or a combination of these materials or a surface-treated object. When using the sheet-like article, its clarity and color are not particularly limited, but it is preferable that the transparency be low and the surface visible to the operator be dark. In this case, dark colors include, but are not limited to, black, navy blue, dark blue, dark green, purple, etc., with black being the most preferred. Furthermore, the transparency (total light transmittance as described above) is preferably 50% or less, more preferably 20% or less, and most preferably 0%. The size of the sheet-like article is not particularly limited, but if it is directly attached (integrated) to the bottom surface of the main body 10, it is preferably the same size as or slightly larger than the edge 60 (the periphery on the underside of the main body 10) described below. Furthermore, from the perspective of making it easier to see the cells or cell aggregates 80 in the liquid, a size similar to the bottom of the first cell storage section 21 or the bottom of the second cell storage section 22 can be used without any problems depending on the application. A preferred embodiment is a cell-holding dish 100 having a black resin plate attached to the bottom surface of the main body 10, but another embodiment is to lay a similar resin plate and perform work with the cell-holding dish 100 placed on it. Another embodiment is to lay a black nonwoven fabric on a workbench and place the cell-holding dish 100 on it.The color tone of the resin plate or nonwoven fabric is not particularly limited as long as it is a dark color, and is preferably a color selected from black, navy blue, dark blue, dark green, purple, etc. The sheet-like product can also be included in the kit described below.

[0037] (Other Components) The cell containment dish 100 according to this embodiment may include any other components that do not affect the aforementioned effects, in addition to the aforementioned main body 10. Furthermore, the main body 10 may also include any other components that do not affect the aforementioned effects, in addition to the aforementioned first cell containment section 21, second cell containment section 22, and waste liquid containment section 25.

[0038] For example, it is more preferable that the cell storage dish 100 according to this embodiment is configured to include a member on the bottom (lower) side of the main body 10 that can further enhance the stability of the cell storage dish when the cell storage dish 100 is placed on a mounting surface with the bottom side facing downward. Examples of such a configuration include, but are not limited to, a configuration in which the cell storage dish 100 includes an edge 60 formed as a flat protruding edge on the lateral side (lateral outer side of the main body 10) of the periphery of the lower surface of the main body 10, as shown in Figures 1 and 2, and at least a portion of the flat surface of the edge 60 comes into contact with the mounting surface when the cell storage dish 100 is placed on the mounting surface.

[0039] Furthermore, it is more preferable that the cell-holding dish 100 according to this embodiment has a configuration in which a member capable of holding another cell-holding dish 100 according to this embodiment stacked on its upper or lower surface is provided, since the cell-holding dishes 100 before and after use can be stored stacked, thereby saving space in the storage area, etc.

[0040] An example of such a configuration is a fitting portion 90 that is disposed on the periphery of the upper surface 11 of the main body portion 10 and that protrudes upward from the upper surface 11 of the main body portion 11, as shown in Figures 1 and 2. In this embodiment, the interior of the main body portion 10 of the cell-containing dish 100 has a hollow structure (hole structure) that is open on the bottom side, as shown in Figures 1 and 2, and the hole structure on the lower surface of the main body portion 10 (the hole region surrounded by the edge portion 60 on the back surface side of the main body portion 10 in Figures 1 and 2) is formed to fit with a fitting portion 90 on the upper surface of the main body portion 10 of another cell-containing dish 100. When the cell-containing dishes 100 are stacked, the hole structure on the lower surface of the main body portion 10 and the fitting portion 90 on the upper surface fit together, enabling them to be held together. However, the present invention is not limited to this.

[0041] These components may be made of a material other than a resin material (such as glass), or may be made of a resin material and a material other than a resin material (a combination of these). However, when the main body 10 is made of a resin material, these components are preferably made of a resin material because they can be easily formed integrally with the main body 10 made of this resin material. It is even more preferable that these components be made of the same resin material as the resin material that makes up the main body 10 (i.e., the entire cell-containing dish 100 according to this embodiment is made of the same resin material).

[0042] <Cell administration kit> Next, an embodiment of a cell administration kit including a cell containment dish 100 according to this embodiment will be described with reference to Figures 5 to 9. Note that Figure 5 is the aforementioned perspective view, Figure 6 is an enlarged view of a portion including the opening 71 and tubular structure portion of a cannula 70 provided in this cell administration kit, and Figures 7 to 9 are all cross-sectional views schematically showing the state when the cannula 70 is placed along the straight portion 31 of the first cell containment section 21 of the cell containment dish 100 according to this embodiment to aspirate and recover cell clumps 80.

[0043] The cell administration kit according to this embodiment is used to administer cells or cell clusters 80 to a living organism and includes the cell-holding dish 100 according to the embodiment described above and a cannula 70, which is a tubular structure made of a resin material and has a substantially elliptical opening 71 through which cells or cell clusters 80 can be drawn into the interior from at least the first cell-holding section 21 of the cell-holding dish 100. The cannula 70 is capable of retaining cells or cell clusters 80 drawn into the interior (hollow region) of the tubular structure. It is more preferable that the cannula 70 have an opening 71 through which cells or cell clusters 80 can also be drawn into the interior from the second cell-holding section 22 of the cell-holding dish 100. The cell administration kit may also be configured to include a plurality of at least one of the cell-holding dishes 100 and the cannula 70. This cell administration kit has the advantage that cells or cell clumps 80 contained in the first cell storage section 21 of the cell storage dish 100 can be easily sucked up and collected using the cannula 70, and the collected cells or cell clumps 80 can be directly administered to a living body using this cannula 70.

[0044] The site of the living body to which the cannula 70 is administered is not particularly limited, but may be, for example, subretinal. In order to easily and reliably administer the cells or cell mass 80 subretinal, it is preferable that the tip of the cannula 70, including the opening 71, is partially bent (bent) or curved, as shown in Figure 5 or 6.

[0045] Similarly, from the viewpoint of facilitating alignment of the tip portion, including the opening 71, of the cannula 70 with the bottom of the first cell storage section 21 of the cell storage dish 100 according to this embodiment, it is more preferable that the tubular structure of the tip portion of the cannula 70 be partially bent (bent) or curved (a partially bent (bent) or curved structure so that the tip portion, including the opening 71, can be aligned with the bottom of the straight section 31), as shown in Figure 5 or 6. Furthermore, the tubular structure of the cannula 70 is not limited, but is more preferably configured to include a hollow region having a cross-sectional major axis 73 (the longest diameter among the inner diameters of the cross section) larger than the major axis 71a of the opening 71 (the longest diameter among the inner diameters of the opening), because this facilitates retention of recovered cells or cell aggregates 80 therein, and even more preferably, the tubular structure is configured such that the number of hollow regions having a cross-sectional major axis 73 larger than the major axis 71a of the opening 71 is greater than the number of hollow regions having a cross-sectional major axis 73 equal to or smaller than the major axis 71a of the opening 71. For example, as shown in the embodiment of FIG. 6 , in a region 75 from the opening 71 in the tubular structure to a predetermined position (the position indicated by reference numeral 77, which is the bent portion (bend) in FIG. 6 ), the cross-sectional major axis 73 of the tubular structure is approximately the same as the major axis 71a of the opening 71. From this predetermined position, the cross-sectional major axis 73 of the tubular structure gradually expands (region 79) to the end of the tubular structure, and region 79 is longer (has a longer extension length) than region 75 in the tubular structure. Furthermore, the size of the opening 71 is not limited. For example, the major axis 71a of the approximately elliptical opening 71 is approximately 0.5 mm to 1.6 mm, and the minor axis (the shortest diameter of the opening's inner diameter) is approximately 0.1 mm to 1.0 mm. The wall thickness of the tip portion of the cannula 70, including the opening 71, can be adjusted by appropriately setting the wall thickness.

[0046] The cell storage dish 100 and cannula 70 of the cell administration kit according to this embodiment more preferably have the following configuration: Specifically, when cells or cell clusters 80 are stored in the first cell storage section 21 of the cell storage dish 100 and are arranged so that they are in partial contact with the bottom of the straight section 31 and the long axis, which is the longest axis of the cells or cell clusters 80, is aligned along the longitudinal direction of the first cell storage section 21 (the longitudinal direction of the straight section 31), the circumscribed circle of the cross section of the cell or cell cluster 80 that is orthogonal to the long axis and the cannula 70 have the opening 71 aligned along the longitudinal direction of the first cell storage section 21 (the longitudinal direction of the straight section 31). ) so that the opening 71 is in partial contact with the bottom of the straight section 31 of the first cell storage section 21 (part of the outer end of the thick wall of the tip portion including the opening 71) when viewed in the longitudinal direction, the area of ​​the region of the circumscribed circle located inside the opening, which is inside the thickness of the cannula 70 forming the opening 71, is greater than the area of ​​the region of the circumscribed circle located outside the opening, which is outside the thickness of the cannula 70 forming the opening 71. This is because the cells or cell clumps 80 stored in the first cell storage section 21 can be easily sucked by the cannula 70 having the predetermined relationship, making recovery easier.

[0047] Here, "cells or cell clusters 80 and cannula 70 being arranged so as to be in partial contact with the bottom of straight section 31" does not necessarily require that they be in partial contact with the deepest line segment of straight section 31, but also encompasses a state in which they are not in contact with this deepest line segment but are in partial contact with the vicinity thereof (e.g., part of inclined surface 33 as shown in FIG. 7). In other words, it is sufficient that cells or cell clusters 80 and cannula 70 are arranged so as to be in contact with at least a portion of the bottom. Furthermore, the long axis of cells or cell clusters 80 refers to the longest axis when cells or cell clusters 80 are elongated, approximately spheroidal (e.g., approximately spheroidal), the longest plate diameter when cells or cell clusters 80 are approximately plate-shaped, any diameter when cells or cell clusters 80 are approximately spherical, and any disk diameter when cells or cell clusters 80 are approximately disk-shaped. Therefore, "the long axis, which is the longest axis of the cell or cell cluster 80, is arranged along the longitudinal direction of the first cell storage section 21" means that, depending on the shape of the cell or cell cluster 80, one of the above directions is arranged along the longitudinal direction of the first cell storage section 21.

[0048] For example, as shown in FIG. 7 , a substantially oblong spheroidal cell mass 80 is accommodated in a first cell accommodation section 21 having a substantially V-shaped concave cross section in the short direction of the straight section 31, with a portion of the cell mass 80 contacting the inclined surface 33 at the bottom and with its major axis aligned along the longitudinal direction of the first cell accommodation section 21, and a cannula 70 is arranged with its opening 71 facing the longitudinal direction of the first cell accommodation section 21 so that both ends of the thick outer side of the opening 71 are partially in contact with the inclined surface 33 at the bottom of the straight section 31. When the opening 71 and the first cell containing section 21 are viewed in the longitudinal direction, it is preferable that the area of ​​the region of the circumscribed circle located inside the opening, which is inside the thickness of the cannula 70 forming the opening 71 (in Figure 7, the region 80a located inside the opening in the cell mass 80) is larger than the area of ​​the region of the circumscribed circle located outside the opening, which is outside the thickness of the cannula 70 forming the opening 71 (in Figure 7, the region 80b located outside the opening in the cell mass 80).

[0049] Furthermore, even in the case where the first cell storage section 21 has a flat surface 35, as shown in FIG. 8 , when a substantially oblong spheroidal cell mass 80 is stored in the first cell storage section 21, the cross section of which in the short direction of the straight section 31 is a concave shape of a substantially inverted trapezoid, and the cell mass 80 is placed so that a portion of the cell mass is in contact with the flat surface 35 at the bottom and the major axis is along the longitudinal direction of the first cell storage section 21, and the cannula 70 is placed so that the opening 71 is facing the longitudinal direction of the first cell storage section 21 and so that the cell mass 80 is in partial contact with the flat surface 35 at the bottom of the straight section 31, When viewed in the longitudinal direction of first cell containing section 21, the area of ​​the circumscribing circle that is located inside the opening, which is inside the thickness of cannula 70 that forms opening 71 (in FIG. 8, area 80a located on the inside side of the opening in cell mass 80) is preferably larger than the area of ​​the circumscribing circle that is located outside the opening, which is outside the thickness of cannula 70 that forms opening 71 (in FIG. 8, area 80b located very slightly on the outside side of the opening in cell mass 80). Note that in the embodiment of FIG. 8, almost no area 80b of the circumscribing circle is located outside the opening, and the center of gravity of cell mass 80 is located inside the opening, which is very preferable.

[0050] On the other hand, as shown in Figure 9, when a substantially oblong cell mass 80 and a cannula 70 are arranged in the same manner as described above (similar to Figure 7) in a first cell storage section 21 in which the cross section in the short direction of the straight portion 31 is a substantially V-shaped concave shape but the angle θ1 is larger than that in Figure 7, when the cell mass 80 and the opening 71 of the cannula 70 are viewed in the longitudinal direction of the first cell storage section 21, if the area of ​​the region of the circumscribed circle that is located inside the opening, which is inside the thickness of the cannula 70 that forms the opening 71 (in Figure 9, the region 80a located on the inside side of the opening in the cell mass 80) is smaller than the area of ​​the region of the circumscribed circle that is located outside the opening, which is outside the thickness of the cannula 70 that forms the opening 71 (in Figure 9, the region 80b located on the outside side of the opening in the cell mass 80), then the ease of suction and recovery of the cell mass 80 by the cannula 70 tends to be somewhat difficult to improve. However, even with this configuration, cell aggregates 80 and the like can be more easily aspirated and collected compared to when the cannula 70 is used to aspirate and collect them from a dish of a conventional shape. When using a cannula 70 having an opening 71 or the like that allows cells or cell aggregates 80 to be directly administered to a living organism, a configuration in which the angle θ1 described above is 30° or less tends to make it difficult to obtain the embodiment shown in FIG. 9 (it tends to make it easier to obtain the embodiment shown in FIG. 7 described above). On the other hand, in the case of an embodiment in which the straight portion 31 has a flat surface 35, even if the angle θ1 described above is greater than 30° (for example, greater than 30° but less than 35°), it tends to make it easier to obtain the embodiment shown in FIG. 8 described above.

[0051] The cell-containing dish 100 and cannula 70 included in the cell administration kit according to this embodiment are preferably sterilized. Sterilization methods include, for example, ethylene oxide gas (EOG) sterilization, steam sterilization, and radiation sterilization, with EOG sterilization being particularly preferred from the perspective of mass production.

[0052] The cell administration kit according to this embodiment, which includes the cell storage dish 100 and cannula 70 described above, is characterized in that the cells or cell clumps 80 stored in the first cell storage section 21 or the like of the cell storage dish 100 can be easily aspirated and collected using the cannula 70, and the aspirated and collected cells or cell clumps 80 can be administered directly to a living body through the cannula 70. Furthermore, because all of the cells or cell clumps 80 stored in the cell storage dish 100 can be easily aspirated and collected using the cannula 70, it is easy to control the dosage and there is little loss.

[0053] Furthermore, the cells or cell clusters 80 administered to a living organism using the cell administration kit including the cell storage dish 100 and cannula 70 according to this embodiment may be any size that does not exceed the depth D1 of the first cell storage section 21 or the depth D2 of the second cell storage section 22 (does not extend above the imaginary line on the main body upper surface 11) when stored in the first cell storage section 21 or the second cell storage section 22. Examples of such cells or cell clusters include, but are not limited to, ES cells, iPS cells, cell clusters prepared using these cells (e.g., substantially spherical or substantially spheroidal clusters or substantially planar cell sheets, tubular tissues, string-like tissues, tissue fragments, etc.), tissues excised from a living organism (e.g., a fetus), etc. Cell clusters (tissues, etc.) that can be prepared by inducing differentiation of ES cells or iPS cells include ectoderm-derived tissues, specifically, nervous system tissues, aggregates of nervous system progenitor cells, and more specifically, tissues containing cells from a specific brain or neural region (tissues containing nerve cells, such as the forebrain, midbrain, cerebrum, spinal cord, and retinal tissue). Other examples of cell masses (tissues, etc.) that can be produced by inducing differentiation of ES cells or iPS cells include endoderm-derived tissues and mesoderm-derived tissues, specifically tissues containing cells of digestive tissues (stomach, intestines, liver, pancreas, etc.), respiratory tissue, urinary tract tissue, skeletal system tissue, muscular system tissue, circulatory system tissues (heart, blood vessels, etc.), pancreatic tissue, intestinal tissue, and urogenital organs (kidneys, etc.). For example, the size of this cell mass is such that both the width and height are about 0.05 mm to 10.0 mm, preferably about 0.1 mm to 5.0 mm, more preferably about 0.2 mm to 3.0 mm, and even more preferably about 0.3 mm to 2.0 mm. By using a cell administration kit including the cell storage dish 100 and cannula 70 according to this embodiment, such cells or cell clusters 80 suspended in a culture medium, preservative solution, or the like can be temporarily stored in the cell storage dish 100, and the cells or cell clusters 80 can then be easily sucked into the interior of the cannula 70 (inside the tubular structure) and collected. The cells or cell clusters 80 can then be administered directly from this cannula 70 to a living organism.

[0054] The above embodiments encompass the following technical concepts: (1) A cell-accommodating dish used to accommodate cells or cell clusters, wherein a main body of the cell-accommodating dish is provided with one or more first cell-accommodating sections that are concave-shaped and have longitudinal and lateral directions and are open on the upper surface side of the main body and are capable of accommodating a liquid containing the cells or cell clusters, the first cell-accommodating section having a straight section that extends linearly in the longitudinal direction longer than its length in the lateral direction, and further having inclined surfaces that slope downward from both ends of the opening in the lateral direction of the straight section toward the bottom side of the concave shape so as to approach each other. (2) The cell-accommodating dish described in (1), wherein the first cell-accommodating section has a flat surface on the bottom side of the concave shape of the straight section that is formed flat to be continuous with the inclined surface and extends linearly in the longitudinal direction. (3) The cell-accommodating dish according to (1) or (2), wherein the first cell-accommodating section slopes downward from the open end of the region other than the straight section toward the bottom of the concave shape so that the sloped surfaces are continuous. (4) The cell-accommodating dish according to any one of (1) to (3), wherein the sloped surfaces of the straight section in the first cell-accommodating section all slope downward so that the angle with the upper surface of the main body is 10° to 35°. (5) The cell-accommodating dish according to any one of (1) to (4), wherein the main body further comprises one or more second cell-accommodating sections each having a substantially conical concave shape, opening on the upper surface of the main body and having a continuous sloped surface that slopes downward from the open end toward the bottom, such that the second cell-accommodating section is capable of accommodating a liquid containing the cells or cell clusters. (6) The cell-accommodating dish according to (5), wherein the depth of the deepest region from the top surface of the main body part in the second cell-accommodating section is deeper than the depth of the deepest region from the top surface of the main body part in the first cell-accommodating section. (7) The cell-accommodating dish according to (5) or (6), wherein the position of the deepest region from the top surface of the second cell-accommodating section in the longitudinal direction of the first cell-accommodating section on the top surface of the main body part is located at the same position as either end of the straight part of the first cell-accommodating section in the longitudinal direction.(8) The cell-accommodating dish according to (7), wherein, in the longitudinal direction of the first cell-accommodating section on the top surface of the main body section, the position of one end of the opening of the second cell-accommodating section is the same as the position of one of the two ends of the opening of the first cell-accommodating section 21. (9) The cell-accommodating dish according to any one of (5) to (8), wherein the angle formed by the inclined surface of the second cell-accommodating section and the top surface of the main body section is larger than the angle formed by the inclined surface of the straight section of the first cell-accommodating section and the top surface of the main body section. (10) The cell-accommodating dish according to any one of (1) to (9), further comprising one or more recessed waste liquid-accommodating sections that open to the top surface of the main body section and are capable of storing waste liquid separated from a liquid containing the cells or cell clumps. (11) The cell-accommodating dish according to any one of (1) to (10), wherein the main body is made of a resin material, more preferably a polyolefin resin, a cyclic polyolefin resin, a polystyrene resin, a polyacrylic resin, a methacrylic resin, a fluorine-containing resin, a cellulose resin, a polyacrylonitrile resin, a polycarbonate resin, a vinyl chloride resin, a polyvinylidene chloride resin, a polyarylate resin, a polysulfone resin, a polyethersulfone resin, a polyetheretherketone resin, or a polyetherimide resin. (12) The cell-accommodating dish according to (11), wherein the main body made of a resin material has a total light transmittance of 70% or more as measured in accordance with JIS K 7375:2008. (13) A cell administration kit used to administer cells or cell clusters to a living organism, comprising: a cell storage dish described in any one of (1) to (12); and a cannula, which is a tubular structure made of a resin material (more preferably the same resin material as the resin material constituting the main body portion) and has an approximately elliptical opening that can suck the cells or cell clusters from the first cell storage portion of the cell storage dish into its interior.(14) The cell administration kit described in (13) is configured such that, when the cells or cell clusters are contained in the first cell storage section of the cell storage dish and are arranged so that the long axis, which is the longest axis of the cells or cell clusters, is partially in contact with the bottom of the straight section and is aligned with the longitudinal direction of the first cell storage section, the circumscribing circle of the cross section of the cell or cell cluster that is perpendicular to the long axis and the opening of the cannula when the opening is oriented in the longitudinal direction of the first cell storage section and is partially in contact with the bottom of the straight section of the first cell storage section, the area of ​​the region of the circumscribing circle that is located inside the opening, which is inside the thickness of the cannula that forms the opening, is larger than the area of ​​the region of the circumscribing circle that is located outside the opening, which is outside the thickness of the cannula that forms the opening, when viewed in the longitudinal direction.

[0055] This application claims priority based on Japanese Patent Application No. 2023-123571, filed on July 28, 2023, the disclosure of which is incorporated herein in its entirety by reference.

[0056] 100 Cell storage dish 10 Main body 11 Main body upper surface 21 First cell storage section 22 Second cell storage section 25 Waste liquid storage section 31 Straight section 33 Inclined surface 35 Flat surface 43 Inclined surface 45 Deepest section 60 Edge 70 Cannula 71 Opening 71a Long diameter of opening 73 Cross-sectional long diameter of hollow region 80 Cell or cell cluster 80a Region of cell or cell cluster arranged on the inner side of the cannula opening 80b Region of cell or cell cluster arranged on the outer side of the cannula opening 90 Fitting section

Claims

1. A cell storage dish used to store cells or cell clusters, the main body of the cell storage dish being provided with one or more first cell storage sections having a concave shape with longitudinal and lateral directions that open to the upper surface side of the main body and are capable of storing a liquid containing the cells or cell clusters, the first cell storage sections having a straight section that extends linearly in the longitudinal direction longer than the length in the lateral direction, and further having inclined surfaces that slope downward from both ends of the opening in the lateral direction of the straight section so as to approach each other toward the bottom side of the concave shape.

2. A cell-containing dish as described in claim 1, wherein the first cell-containing section has a flat surface on the bottom side of the concave shape in the straight section, which is formed flat so as to be continuous with the inclined surface and extends linearly in the longitudinal direction.

3. A cell storage dish as described in claim 1 or 2, wherein the first cell storage section slopes downward from the opening end of the area other than the straight section toward the bottom side of the concave shape so that the inclined surface is continuous.

4. A cell storage dish as described in claim 1 or 2, wherein the inclined surfaces of the straight portion in the first cell storage section all slope downwardly so that the angle with the upper surface of the main body section is greater than or equal to 10° and less than or equal to 35°.

5. A cell storage dish as described in claim 1 or 2, further comprising one or more second cell storage sections, each of which is approximately conical and concave and has an opening on the upper side of the main body and a continuous inclined surface that slopes downward from the opening end toward the bottom side so as to approach each other, and which are capable of storing a liquid containing the cells or cell clusters.

6. A cell-containing dish as described in claim 5, wherein the depth of the deepest region from the top surface of the main body portion in the second cell-containing portion is deeper than the depth of the deepest region from the top surface of the main body portion in the first cell-containing portion.

7. A cell storage dish as described in claim 5, wherein, in the longitudinal direction of the first cell storage section on the upper surface of the main body, the position of the deepest area from the upper surface of the second cell storage section is located at the same position as either end of the longitudinal direction of the straight portion of the first cell storage section.

8. A cell-containing dish as described in claim 1 or 2, further comprising one or more concave waste liquid storage sections opening on the upper surface side of the main body, capable of storing waste liquid separated from the liquid containing the cells or cell clusters.

9. The cell-containing dish according to claim 1 or 2, wherein the main body is made of a resin material.

10. The cell storage dish according to claim 9, wherein the main body made of the resin material has a total light transmittance of 70% or more as measured in accordance with JIS K 7375:2008.

11. A cell administration kit used for administering cells or cell clusters to a living organism, comprising: a cell containing dish as described in claim 1 or 2; and a cannula made of a resin material and having a tubular structure with a substantially elliptical opening capable of sucking the cells or cell clusters from the first cell containing portion of the cell containing dish into its interior.

12. The cell administration kit according to claim 11, wherein, when the cell or cell cluster is contained in the first cell storage section of the cell storage dish and is arranged so that the cell or cell cluster is partially in contact with the bottom of the straight section and the long axis, which is the longest axis of the cell or cell cluster, is aligned along the longitudinal direction of the first cell storage section, the circumscribing circle of the cross section of the cell or cell cluster that is perpendicular to the long axis and has the largest area, and when the cannula is arranged so that the opening faces the longitudinal direction of the first cell storage section and is partially in contact with the bottom of the straight section of the first cell storage section, the area of ​​the region of the circumscribing circle that is located inside the opening, which is inside the thickness of the cannula that forms the opening, is larger than the area of ​​the region of the circumscribing circle that is located outside the opening, which is outside the thickness of the cannula that forms the opening, when viewed in the longitudinal direction.

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