Vascular intervention medical device and system, and application thereof

Abstract

Disclosed in the present invention are a vascular intervention medical device and system, and the application thereof. The vascular intervention medical device comprises a main body frame, an electric signal transmission assembly and an electromagnetic shielding member, wherein the main body frame is an elastic supporting frame; the electric signal transmission assembly is arranged on the main body frame and comprises an electrode and a wire which are electrically connected; and the electromagnetic shielding member is configured to reduce or block interference of external electromagnetic signals to electric signals transmitted by the electric signal transmission assembly. Providing an electromagnetic shielding member can reduce or block the interference of external electromagnetic signals to electric signals transmitted by the electric signal transmission assembly, thereby improving the electric signal transmission accuracy of the vascular intervention medical device.

Description

A vascular interventional medical device, system and application thereof Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a vascular interventional medical device, system and application thereof. Background Art

[0002] Each organ in the human body is supplied with blood by arteries, which provide oxygen and nutrients to the tissues. Blood then returns to the heart (atria) via veins. If arterial stenosis, caused by various factors, reaches a certain level, tissue and organ ischemia and hypoxia can occur, leading to tissue remodeling, damage, and necrosis, resulting in ischemic diseases of various organs (such as coronary artery ischemia leading to coronary heart disease). In recent years, with advancements in technology, methods, software, hardware, and equipment, vascular interventional therapy has become an increasingly important medical practice. This includes interventional therapy for coronary heart disease, renal artery interventional therapy, carotid artery interventional therapy, aortic interventional therapy, and interventional therapy for upper and lower limb arteries. Existing vascular interventional medical devices generally include an internal stent with electrodes fixed to the stent. Thin wires are then connected to the electrodes via resistance welding and led to a telemetry circuit, enabling the transmission of electrical signals between the blood vessel and an external circuit to detect relevant health information. However, because interventional medical devices require access to blood vessels, they are small in size, and the electrical signals they transmit are generally weak, making them easily interfered with by external electromagnetic signals, which in turn affects the accuracy of signal transmission.

[0003] Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a vascular interventional medical device, system and application thereof.

[0005] A first aspect of the present invention provides a vascular interventional medical device comprising:

[0006] A main frame, wherein the main frame is an elastic support frame;

[0007] an electrical signal transmission component, the electrical signal transmission component being disposed on the main frame and comprising electrodes and wires, the wires being electrically connected to the electrodes;

[0008] An electromagnetic shielding component is configured to reduce or block interference of external electromagnetic signals on the electrical signal transmitted by the electrical signal transmission component.

[0009] According to an embodiment of the present invention, the vascular interventional medical device has at least the following beneficial effects: the vascular interventional medical device is further configured with an electromagnetic shielding component on the basis of arranging an electrical signal transmission component including electrodes and wires on an elastic main frame, so as to reduce or block the interference of external electromagnetic signals on the electrical signals transmitted by the electrical signal transmission component through the electromagnetic shielding component, thereby improving the accuracy of electrical signal transmission of the vascular interventional medical device.

[0010] In some embodiments of the present invention, the electromagnetic shielding component is provided on at least one side of the electrical signal transmission component.

[0011] In some embodiments of the present invention, the electromagnetic shielding component is provided on a side of the electrical signal transmission component away from the main frame, covering the wires and exposing at least a portion of the electrodes.

[0012] In some embodiments of the present invention, the electromagnetic shielding component is provided between the electrical signal transmission component and the main frame.

[0013] In some embodiments of the present invention, the electromagnetic shielding component is disposed between the electrical signal transmission component and the main frame, and on a side of the electrical signal transmission component away from the main frame, covering the wire and exposing at least part of the electrode.

[0014] In some embodiments of the present invention, the electromagnetic shielding member is disposed around the electrical signal transmission component and exposes at least a portion of the electrode.

[0015] In some embodiments of the present invention, an insulating layer is provided between the electromagnetic shielding component and the electrical signal transmission component.

[0016] In some embodiments of the present invention, the electromagnetic shielding component is any one of a metal shielding layer, a carbon nanotube shielding layer, a ferrite shielding layer, and a graphene shielding layer; preferably, the material of the metal shielding layer is selected from at least one of platinum and gold.

[0017] In some embodiments of the present invention, the material of the insulating layer is selected from at least one of polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8.

[0018] In some embodiments of the present invention, the electrical signal transmission component is configured from a conductive material layer.

[0019] In some embodiments of the present invention, the electrode and the wire are integrated into one structure.

[0020] In some embodiments of the present invention, the conductive material layer is a metal material layer, a non-metallic conductive material layer, or a composite layer of a non-metallic conductive material layer and a metal material layer.

[0021] In some embodiments of the present invention, the conductive material layer includes a non-precious metal conductive base layer and a precious metal protective layer, the non-precious metal conductive base layer is arranged on the surface of the main frame, and the precious metal protective layer covers the non-precious metal conductive base layer; the material of the precious metal protective layer is selected from at least one of platinum and gold.

[0022] In some embodiments of the present invention, the thickness of the conductive material layer is less than 5 μm.

[0023] In some embodiments of the present invention, the main frame is configured to be contractible and expandable along a central axis.

[0024] In some embodiments of the present invention, the main frame is in the shape of a hollow tube.

[0025] In some embodiments of the present invention, the side walls of the main frame are in a mesh structure.

[0026] In some embodiments of the present invention, the electrodes are provided at intersections of the mesh structures on the main frame.

[0027] In some embodiments of the present invention, there are two or more electrodes.

[0028] In some embodiments of the present invention, the electrodes are evenly distributed along the radial direction and / or the axial direction of the main frame.

[0029] In some embodiments of the present invention, the surface of the electrode is provided with a modified layer, which has a biological signal recognition function for identifying and detecting changes in biological signals within blood vessels, and converting the changes in the biological signals into readable electrical signals through the electrode and transmitting them to an external circuit; the biological signals include chemical signals and / or physical signals related to the physiological condition of the organism.

[0030] In some embodiments of the present invention, the material of the modification layer is selected from at least one of enzymes, redox mediators, nanomaterials, antibodies, biotin, nucleic acid aptamers, polymers, ion carriers, and piezoelectric materials.

[0031] In some embodiments of the present invention, the enzyme is selected from at least one of oxidoreductase, transferase, hydrolase, lyase, ligase, and isomerase.

[0032] In some embodiments of the present invention, the oxidoreductase is selected from the group consisting of glucose oxidase, glutamate oxidase, alcohol oxidase, lactate oxidase, amino acid oxidase, cholesterol oxidase, choline oxidase, nicotinamide adenine dinucleotide phosphate oxidase, oxalate oxidase, cytochrome oxidase, bilirubin oxidase, serotoninase, galactose oxidase, glucose dehydrogenase, lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, glutamate dehydrogenase, pyruvate dehydrogenase, sorbitol dehydrogenase, formate dehydrogenase, cellobiose dehydrogenase, amino acid dehydrogenase, succinate dehydrogenase, catalase, At least one of horseradish peroxidase, lactoperoxidase, glutathione peroxidase, ascorbate peroxidase, soybean peroxidase, cytochrome peroxidase, thyroid peroxidase, myeloperoxidase, superoxide dismutase, haloperoxidase, thiol peroxidase, 5α-reductase, 5β-reductase, aldehyde reductase, aldose reductase, hydroxymethylglutaryl-CoA reductase, methemoglobin reductase, ribonucleotide reductase, nitroreductase, thioredoxin reductase, dihydrofolate reductase, disulfide reductase, sulfite reductase, cytochrome reductase, imine reductase, fumarate reductase, carboxylic acid reductase, and dimethyl sulfoxide reductase.

[0033] In some embodiments of the present invention, the transferase is selected from at least one of glutathione transferase, acetyltransferase, methyltransferase, transketolase, transaldolase, glycosyltransferase, transketolase, aminoacid transferase, and acyltransferase.

[0034] In some embodiments of the present invention, the hydrolase is selected from at least one of lipase, phosphohydrolase, glycoside hydrolase, acetylhydrolase, nucleotide hydrolase, helicase, peptide hydrolase, urease, and creatinine deiminase.

[0035] In some embodiments of the present invention, the lyase is selected from at least one of a decarboxylase, a dehydrogenase, a dehalogenase, an aspartate ammonia lyase, and a cysteine ​​desulfurase.

[0036] In some embodiments of the present invention, the ligase is at least one selected from tRNA synthetase, succinyl-coenzyme A synthetase, amino acid ligase, DNA ligase, RNA ligase, and carboxylase.

[0037] In some embodiments of the present invention, the isomerase is selected from at least one of a racemase, an epimerase, and a mutase.

[0038] In some embodiments of the present invention, the nanomaterial is selected from at least one of metal nanomaterials, nanoceramics, nanoglass, and nanopolymer materials.

[0039] In some embodiments of the present invention, the antibody is selected from at least one of C-reactive protein antibody, thyrotropin antibody, bilirubin antibody, albumin antibody, carcinoembryonic antigen antibody, alpha-fetoprotein antibody, prostate-specific antigen antibody, cancer antigen 125 antibody, and cortisol antibody.

[0040] In some embodiments of the present invention, the nucleic acid aptamer is selected from at least one of a DNA type oligonucleotide chain and an RNA type oligonucleotide chain.

[0041] In some embodiments of the present invention, the polymer is selected from at least one of polyaniline, polypyrrole, polyacetylene, polycarbazole, polythiophene, polyphenylene methylene, poly(3,4-ethylenedioxythiophene), polystyrene sulfonic acid, chitin, chitosan, polyvinyl chloride, polyvinyl butyral, and Nafion.

[0042] In some embodiments of the present invention, the ion carrier is selected from at least one of potassium ion, sodium ion, calcium ion, magnesium ion, iron ion, zinc ion, manganese ion, copper ion, molybdenum ion, cobalt ion, cobalt ion, chromium ion, chloride ion, sulfate ion, and phosphate ion.

[0043] In some embodiments of the present invention, the piezoelectric material is selected from at least one of single crystal piezoelectric ceramics, polycrystalline piezoelectric ceramics, piezoelectric polymers, and polymer-piezoelectric ceramic composites.

[0044] In some embodiments of the present invention, the area on the main frame corresponding to the setting position of the electrical signal transmission component constitutes an electrical signal transmission component assembly part, and along the direction toward the center of the main frame, the outer contour size of the electrical signal transmission component assembly part is equal to or greater than the outer contour size of the corresponding area of ​​the electromagnetic shielding component.

[0045] In some embodiments of the present invention, an electrical signal transmission component assembly groove is provided on the electrical signal transmission component assembly portion, and the electrical signal transmission component is assembled in the electrical signal transmission component assembly groove.

[0046] In some embodiments of the present invention, the material of the main frame is selected from degradable polymer materials; or, the material of the main frame is selected from at least one of shape memory alloys and iron, and a dielectric layer is provided on the surface of the main frame, and the dielectric layer is arranged toward the side of the electrical signal transmission component.

[0047] In some embodiments of the present invention, the material of the dielectric layer is selected from at least one of polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8.

[0048] In some embodiments of the present invention, the shape memory alloy is selected from at least one of Nitinol alloy, cobalt-chromium alloy, and magnesium alloy.

[0049] In some embodiments of the present invention, the vascular interventional medical device further comprises an insulating packaging layer, which is disposed as the outermost layer on the side of the main frame where the electrical signal transmission component is provided, and exposes at least a portion of the electrode.

[0050] In some embodiments of the present invention, the insulating packaging layer is made of at least one material selected from polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8.

[0051] In some embodiments of the present invention, the vascular interventional medical device further includes a buffer protection component, which is disposed at the implantation front end of the vascular interventional medical device and is configured to reduce the risk of puncturing a blood vessel during the implantation process of the vascular interventional medical device.

[0052] In some embodiments of the present invention, the vascular intervention medical device further includes a delivery component configured to deploy and implant the vascular intervention medical device into a blood vessel.

[0053] The second aspect of the present invention provides a vascular interventional medical system, comprising any vascular interventional medical device provided in the first aspect of the present invention.

[0054] The third aspect of the present invention proposes the use of any one or more vascular interventional medical devices in constructing an in vitro cultured cell construct, an electrical signal acquisition cell construct, or an electrical stimulation cell construct. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] The present invention will be further described below with reference to the accompanying drawings and embodiments, in which:

[0056] FIG1 is a schematic structural diagram of an embodiment of a vascular interventional medical device according to the present invention;

[0057] FIG2 is a schematic structural diagram of the vascular interventional medical device shown in FIG1 after being deployed along line AA on the side wall;

[0058] FIG3 is a partial enlarged view of the M area in FIG2 ;

[0059] FIG4 is an enlarged cross-sectional view along line BB of FIG3 ;

[0060] FIG5 is a partial enlarged view of the N region in FIG4 ;

[0061] FIG6 is a schematic structural diagram of the main frame of the vascular interventional medical device shown in FIG2 after deployment;

[0062] FIG7 is a schematic structural diagram of the dielectric layer of the vascular interventional medical device after deployment shown in FIG2 ;

[0063] FIG8 is a schematic structural diagram of the first electromagnetic shielding component in the vascular interventional medical device shown in FIG2 after deployment;

[0064] FIG9 is a schematic structural diagram of the first insulating layer in the vascular interventional medical device after deployment shown in FIG2 ;

[0065] FIG10 is a schematic structural diagram of the electrical signal transmission component in the vascular interventional medical device shown in FIG2 after deployment;

[0066] FIG11 is a schematic structural diagram of the second insulating layer in the vascular interventional medical device after deployment shown in FIG2 ;

[0067] FIG12 is a schematic structural diagram of the second electromagnetic shielding component in the vascular interventional medical device shown in FIG2 after deployment;

[0068] FIG13 is a schematic structural diagram of the insulating packaging layer in the vascular interventional medical device shown in FIG2 after deployment. DETAILED DESCRIPTION

[0069] The following describes embodiments of the present invention in detail. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended only to explain the present invention and are not to be construed as limiting the present invention.

[0070] In the description of the present invention, "several" means more than one, "plurality" means more than two, "greater than," "less than," and "exceed" are understood to exclude the number itself, while "above," "below," and "within" are understood to include the number itself. The use of "first" and "second" in the description is solely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, implicitly specifying the number of the indicated technical features, or implicitly specifying the order of the indicated technical features.

[0071] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, and connecting should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0072] In the description of the present invention, reference to terms such as "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the exemplary expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0073] Referring to Figures 1 to 5 and 10 , the vascular interventional medical device includes a main frame 10, an electrical signal transmission assembly 20, an insulating packaging layer 30, and an electromagnetic shielding element 40. The main frame 10 is an elastic support frame; the electrical signal transmission assembly 20 is disposed on the main frame 10 and includes an electrode 21 and a wire 22, which is electrically connected to the electrode 21; the insulating packaging layer 30 is disposed on the outermost layer of the main frame 10 on the side where the electrical signal transmission assembly 20 is disposed, and exposes at least a portion of the electrode 21; and the electromagnetic shielding element 40 is disposed between the insulating packaging layer 30 and the main frame 10 and is configured to reduce or block interference of external electromagnetic signals on the electrical signals transmitted by the electrical signal transmission assembly.

[0074] The vascular interventional medical device is mainly configured for vascular interventional diagnosis and treatment, and the main frame 10 is generally configured to be able to contract and expand along the central axis. It can contract and expand with the blood vessel in the blood vessel to facilitate implantation into the blood vessel and keep the device in contact with the inner wall of the blood vessel for stable support. Specifically, the main frame 10 can be designed to be a hollow tube, such as a hollow circular tube, a hollow C-shaped tube, etc. Through the above tubular structure and elastic deformable design, the adaptability to the blood vessel can be improved, and the compatibility and detection accuracy can be improved. The diameter of the main frame 10 can be designed to be 1 to 10 mm, the length can be designed to be 10 to 100 mm, and the side wall thickness can be designed to be 10 μm to 1 mm. In order to further reduce blood flow obstruction, improve the portability of the device structure and reduce the foreign body and discomfort caused by the device intervention in the organism, the main frame 10 can be designed to have a mesh structure on the side wall; of course, in some embodiments, the side wall can also adopt other hollow structure designs, or even no hollow design. The main frame 10 having a mesh structure or other hollow structure can be formed by first providing a base support layer and then hollowing out the base support layer by laser engraving or etching to form the mesh structure or other hollow structure; alternatively, the main frame 10 having a mesh structure can be formed by weaving a plurality of main strips. Referring to Figures 1 to 6, in this embodiment, the main frame 10 is a hollow C-shaped tube with mesh-like sidewalls.

[0075] In addition, the material of the main frame 10 can be selected as needed, and specifically a deformable material with biocompatibility can be selected. For example, a degradable polymer material can be used, or at least one of a shape memory alloy and iron can be used, wherein the shape memory alloy can specifically be selected from at least one of a nitinol alloy, a cobalt-chromium alloy, and a magnesium alloy. In addition, if the material of the main frame 10 is a conductive material (such as a shape memory alloy, iron, etc.), it is generally necessary to ensure that the main frame 10 and other conductive components are electrically isolated. Therefore, a dielectric layer 50 for achieving electrical insulation is usually provided between the main frame 10 and other conductive components; and if the material of the main frame 10 is an insulating material, such as an insulating degradable polymer material, the dielectric layer 50 can be cancelled. Among them, the material of the dielectric layer 50 can be selected from at least one of polyimide (PI), polydimethylsiloxane (PDMS), polyparaphenylene benzobisoxazole (PBO), and SU8. In this embodiment, the material of the main frame 10 is selected from Nitinol alloy, and the surface of the main frame 10 is provided with a dielectric layer 50 formed by polyimide. The dielectric layer 50 is specifically provided on the surface of the main frame 10 on the side where the electrical signal transmission component 20 is provided, as shown in Figures 4, 5 and 7.

[0076] The electrical signal transmission component 20 can be configured as required. In some embodiments, the wire 22 and the electrode 21 can be arranged on the main frame 10 and connected by resistance welding to form the electrical signal transmission component 20, wherein the wire 22 and the electrode 21 can be arranged on the main frame 10 by bonding or other means. However, since the vascular interventional diagnosis and treatment device itself is relatively small in size, if the wire 22 is arranged on the mesh structure of the main frame 10, the size of the wire 22 is generally required to be thin, and it is connected to the electrode 21 by resistance welding, and the connection stability is relatively poor. In this embodiment, the electrical signal transmission component 20 is configured with a conductive material layer, and the conductive material layer is configured to form an electrical signal transmission component 20 containing an electrode 21 and a wire 22, wherein the electrode 21 and the wire 22 are an integrated structure, as shown in Figure 10. During the preparation process, the corresponding conductive material can be configured to form a conductive material base layer, and then the electrode 21 and the wire 22 can be obtained by laser engraving or etching to form the electrical signal transmission component 20. The above-mentioned electrical signal transmission component 20 including electrodes 21 and wires 22 is formed by configuring the conductive material layer, which can meet the requirements of thin wires. The width of the wires 22 can be controlled to be less than 100 μm, or even less than 25 μm, and even less than 10 μm, such as 5 μm, 8 μm, etc., and the thickness can be controlled to be less than 5 μm; and the electrodes 21 and the wires 22 can be made into an integrated structure, which is not easy to break even when subjected to blood flow erosion in the blood vessels for a long time, has strong stability, and has a simple structure.

[0077] The electrical signal transmission component 20 can be arranged on the inner side or the outer side of the main frame 10, and can be specifically arranged according to the detection needs. For example, if the target detection object of the vascular interventional diagnosis and treatment device is blood, the electrical signal transmission component 20 can be arranged on the inner side of the main frame 10; if the target detection or action object of the vascular interventional diagnosis and treatment device is blood vessels or vascular wall cells, such as the vascular interventional diagnosis and treatment device is used to electrically stimulate vascular wall cells, the electrical signal transmission component 20 can be arranged on the outer side of the main frame 10. As shown in Figure 1, in this embodiment, the electrical signal group transmission component 20 is arranged on the outer side of the main frame 10. The electrical signal transmission component 20 or the conductive material layer that constructs the electrical signal transmission component 20 generally adopts a biocompatible conductive material, including a metal material and / or a non-metallic conductive material. For example, the conductive material layer that constructs the electrical signal transmission component 20 can be a metal material layer, a non-metallic conductive material layer, or a composite layer of a non-metallic conductive material layer and a metal material layer. Furthermore, to ensure biocompatibility, the metal material layer is generally made of a precious metal, such as platinum or gold. The non-metallic conductive material layer is also typically made of a biocompatible non-metallic conductive material, with no specific limitation on the type. Furthermore, if the conductive material layer of the electrical signal transmission component 20 is formed by combining a non-metallic conductive material layer with a metal material layer, and the metal layer is disposed over the non-metallic conductive material layer to isolate and block the non-metallic conductive material layer, the non-metallic conductive material layer may not even be required to be biocompatible, requiring only the outermost metal layer to be made of a biocompatible metal material, such as platinum or gold. To save costs or enhance conductivity, the conductive material layer of the electrical signal transmission component 20 can be designed to be composed of a non-precious metal conductive base layer and a precious metal protective layer covering the non-precious metal conductive base layer. The non-precious metal conductive base layer can be made of a non-metallic conductive material and / or a non-precious metal-like material, such as a non-precious metal conductive base layer or a non-precious metal-like metal conductive base layer. The precious metal protective layer can be made of at least one of platinum and gold. Among them, the metal material layer can be made by at least one method of sputtering, evaporation, and chemical vapor deposition. The metal material layer prepared by the above methods has good uniformity and strong adhesion stability, which can improve the stability of the structure.

[0078] The number of electrodes 21 configured on the electrical signal transmission component 20 or the conductive material layer that constructs the electrical signal transmission component 20 can be designed to be one or more (such as 2, 3, 5, 8, 10, 15, 20, etc.), and can be set specifically according to actual needs, generally more than two, to achieve multi-point detection or action, improve detection accuracy or action uniformity; and, the electrodes 21 can be evenly arranged along the radial and / or axial direction of the hollow tubular main frame to further improve the detection accuracy or action uniformity, and improve the stability of the structure.

[0079] For a main frame 10 with a mesh-like sidewall structure, the electrodes 21 in the electrical signal transmission assembly 20 can be positioned at the intersections of the mesh structure on the main frame 10, thereby improving the stability of the electrodes 21. As shown in Figures 1 and 2, in this embodiment, the electrodes 21 are positioned at some of the intersections of the mesh structure on the main frame 10. In some embodiments, the electrodes 21 can also be positioned at all intersections of the mesh structure on the main frame 10. Of course, in some embodiments, the electrodes 21 can be positioned between two intersections rather than at the intersections of the mesh structure on the main frame 10. The shape of the electrodes 21 can be designed as needed, generally employing gently curved shapes such as circular, elliptical, semicircular, or annular to enhance the safety of the structure within the human body. In some embodiments, the electrodes 21 can also employ other shapes, such as square.

[0080] In addition, a modified layer may be provided on the surface of the electrode 21. The modified layer may be specifically configured to have a biosignal recognition function, for identifying and detecting changes in biosignals within the blood vessels, and converting the changes in biosignals into readable electrical signals through the electrode 21 and transmitting them to an external circuit. Biosignals include chemical signals and / or physical signals related to the physiological condition of an organism (such as a human body). Among them, the chemical signal may be a chemical signal generated by a chemical reaction with the modified layer material. For example, during the use of the medical device, when a specific biomarker within the blood vessel comes into contact with the modified layer with a biosignal recognition function modified on the surface of the electrode 21, a chemical reaction occurs between the two. The chemical signal change generated by the chemical reaction will be converted into a readable electrical signal through the electrode 21 and transmitted to an external circuit. The physical signal may be at least one of temperature, blood flow velocity, and blood pressure. For example, during the use of the medical device, when the above physical signals in the blood vessel change, the change will cause a responsive change in the physical properties of the modified layer on the surface of the electrode 21, and the change will be converted into a readable electrical signal through the electrode 21 and transmitted to an external circuit.

[0081] The specific material of the modification layer is not limited as long as it can achieve the above-mentioned biological signal recognition function. For example, it can be one or more of enzymes, redox mediators, nanomaterials, antibodies, biotin, nucleic acid aptamers, polymers, ion carriers, and piezoelectric materials.

[0082] The enzyme includes but is not limited to at least one of oxidoreductase, transferase, hydrolase, lyase, ligase, and isomerase.

[0083] Oxidoreductases include, but are not limited to, glucose oxidase, glutamate oxidase, alcohol oxidase, lactate oxidase, amino acid oxidase, cholesterol oxidase, choline oxidase, nicotinamide adenine dinucleotide phosphate oxidase, oxalate oxidase, cytochrome oxidase, bilirubin oxidase, serotoninase, galactose oxidase, glucose dehydrogenase, lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, glutamate dehydrogenase, pyruvate dehydrogenase, sorbitol dehydrogenase, formate dehydrogenase, cellobiose dehydrogenase, amino acid dehydrogenase, succinate dehydrogenase, catalase, horseradish peroxidase, lactoperoxidase, glutathione peroxidase At least one of enzymes, ascorbate peroxidase, soybean peroxidase, cytochrome peroxidase, thyroid peroxidase, myeloperoxidase, superoxide dismutase, haloperoxidase, thiol peroxidase, 5α reductase, 5β reductase, aldehyde reductase, aldose reductase, hydroxymethylglutaryl-CoA reductase, methemoglobin reductase, ribonucleotide reductase, nitroreductase, thioredoxin reductase, dihydrofolate reductase, disulfide reductase, sulfite reductase, cytochrome reductase, imine reductase, fumarate reductase, carboxylic acid reductase, and dimethyl sulfoxide reductase.

[0084] The transferase includes, but is not limited to, at least one of glutathione transferase, acetyltransferase, methyltransferase, transketolase, transaldolase, glycosyltransferase, transketolase, aminoacid transferase, and acyltransferase.

[0085] The hydrolase includes, but is not limited to, at least one of lipase, phosphohydrolase, glycoside hydrolase, acetylhydrolase, nucleotidase, helicase, peptide hydrolase, urease, and creatinine deiminase.

[0086] Lyases include, but are not limited to, at least one of decarboxylase, dehydrogenase, dehalogenase, aspartate ammonia lyase, and cysteine ​​desulfurase.

[0087] The ligase includes, but is not limited to, at least one of tRNA synthetase, succinyl-coenzyme A synthetase, amino acid ligase, DNA ligase, RNA ligase, and carboxylase.

[0088] The isomerase includes, but is not limited to, at least one of a racemase, an epimerase, and a mutase.

[0089] Nanomaterials include, but are not limited to, one or more of metal nanomaterials, nanoceramics, nanoglass, and nanopolymer materials.

[0090] The antibodies include, but are not limited to, one or more of C-reactive protein antibodies, thyroid-stimulating hormone antibodies, bilirubin antibodies, albumin antibodies, carcinoembryonic antigen antibodies, alpha-fetoprotein antibodies, prostate-specific antigen antibodies, cancer antigen 125 antibodies, and cortisol antibodies.

[0091] The nucleic acid aptamer is selected from at least one of a DNA type oligonucleotide chain and an RNA type oligonucleotide chain.

[0092] The polymer is selected from one or more of polyaniline, polypyrrole, polyacetylene, polycarbazole, polythiophene, polyphenylene methylene, poly(3,4-ethylenedioxythiophene), polystyrene sulfonic acid, chitin, chitosan, polyvinyl chloride, polyvinyl butyral, and Nafion.

[0093] The ion carrier is selected from one or more of potassium ion, sodium ion, calcium ion, magnesium ion, iron ion, zinc ion, manganese ion, copper ion, molybdenum ion, cobalt ion, cobalt ion, chromium ion, chloride ion, sulfate ion, and phosphate ion.

[0094] The piezoelectric material is selected from at least one of single crystal piezoelectric ceramics, polycrystalline piezoelectric ceramics, piezoelectric polymers, and polymer-piezoelectric ceramic composites.

[0095] Specifically, among the above-mentioned modifying layer materials, the mechanism of action of some modifying layer materials is as follows: when the vascular interventional diagnostic and treatment device is implanted in a blood vessel and used, if the modifying layer detects a corresponding biological signal change, the modifying layer material will undergo a corresponding chemical reaction, generating or consuming electrons during the chemical reaction. The change in the number of electrons, under the stimulation of the signal of the external circuit, will be conducted through the electrode below the modifying layer and generate an electrical signal, which is ultimately transmitted to the external circuit to form a readable signal. Among them, the enzyme and the redox mediator mainly achieve the above mechanism by cooperating, and the nanomaterial alone or in combination with the redox mediator can also achieve the above mechanism. For example, if glucose oxidase is used as the modifying layer material, but glucose molecules appear in the blood vessel, the glucose oxidase will specifically react with glucose. The electrons generated by the reaction will be transferred to the oxygen in the blood and generate hydrogen peroxide on the electrode surface. The hydrogen peroxide will react chemically under the stimulation of the appropriate external circuit voltage and generate electrons. The electrons will flow from the electrode into the circuit under the drive of the electric field force and generate a readable current signal in the external circuit. The magnitude of the current signal is related to the glucose concentration in the blood vessel, thus, it can be used to judge the glucose concentration in the blood vessel.

[0096] The mechanism of action of some modification layer materials is as follows: When the vascular interventional diagnostic and treatment device is implanted in a blood vessel and used, if the modification layer detects changes in biological signals within the blood vessel, the modification layer material will undergo corresponding chemical changes. After the chemical reaction, the impedance properties of the modification layer will change. This change in impedance properties can be detected by the electrode under the modification layer under the signal excitation of the external circuit and generate an electrical impedance signal. This electrical impedance signal will eventually be transmitted to the external circuit to form a readable signal. Among them, nanomaterials, antibodies, biotin, nucleic acid aptamers, and polymers can all achieve the above mechanism alone or in combination with each other. For example, if cortisol antibodies are used as the modification layer material, when cortisol molecules appear in the blood vessels, the cortisol molecules will specifically chemically bind to the cortisol antibodies. After binding, the impedance of the electrode surface will increase. This impedance signal change can be read in the external circuit. The change in the electrical impedance signal is related to the concentration of cortisol molecules in the blood vessels, and therefore can be used to determine the cortisol concentration in the blood vessels.

[0097] The electromagnetic shielding component 40 is configured to reduce or block the interference of external electromagnetic signals on the electrical signals transmitted by the electrical signal transmission component. Specifically, the electromagnetic shielding component 40 can be set on at least one side of the electrical signal transmission component 20, and the setting method can be configured according to actual needs (including the detection needs of the vascular interventional medical device and the setting position of the electrical signal transmission component 20). For example, if the electrical signal transmission component 20 is arranged on the inner side of the main frame 10, the electromagnetic shielding component 40 can be arranged between the electrical signal transmission component 20 and the main frame 10, and then the electromagnetic shielding component 40 is located on the outside of the electrical signal transmission component 20, which can reduce the interference of external electromagnetic signals to a certain extent; if the electrical signal transmission component 20 is arranged on the outside of the main frame 10, the electromagnetic shielding component 40 can be arranged on the side of the electrical signal transmission component 20 away from the main frame 10, and the electromagnetic shielding component 40 covers the wire 22 and exposes at least part of the electrode 21, and then the electromagnetic shielding component 40 is also located on the outside of the electrical signal transmission component 20, which can reduce the interference of external electromagnetic signals to a certain extent; in some embodiments, the above-mentioned electromagnetic shielding components 40 arranged between the electrical signal transmission component 20 and the main frame 10, and arranged on the side of the electrical signal transmission component 20 away from the main frame 10, covering the wire 22 and exposing at least part of the electrode 21, can also be used to improve the electromagnetic shielding effect by arranging electromagnetic shielding components 40 on both sides of the electrical signal transmission component 20.

[0098] In this embodiment, the electromagnetic shielding assembly 40 is configured to surround the electrical signal transmission assembly 20 and expose at least a portion of the electrode 21 . Specifically, as shown in Figures 4-5 and Figures 8 and 12, in this embodiment, the battery shielding assembly 40 includes a first electromagnetic shielding member 41 and a second electromagnetic shielding member 42. The first electromagnetic shielding member 41 is disposed between the electrical signal transmission assembly 20 and the main frame 10. The second electromagnetic shielding member 42 is disposed on a side of the electrical signal transmission assembly 20 facing away from the main frame 10, covering the conductive wires 22 and exposing at least a portion of the electrodes 21. The second electromagnetic shielding member 42 has a conductive connection portion 43. The second electromagnetic shielding layer 42 is connected to the first electromagnetic shielding member 41 via the conductive connection portion 43. The conductive connection portions 43 are evenly distributed on the second electromagnetic shielding member 42 in a circumferential direction corresponding to the electrical signal transmission assembly 20 (only a portion is shown in Figure 12). Therefore, the first electromagnetic shielding member 41, the second electromagnetic shielding member 42, and the conductive connection portions 43 therebetween are disposed around the electrical signal transmission assembly 20. By surrounding the electrical signal transmission assembly 20, all-round protection can be achieved, effectively blocking interference of external electromagnetic signals on the electrical signals transmitted by the electrical signal transmission assembly 20.

[0099] In some embodiments, the electromagnetic shielding element 40 is generally a conductive electromagnetic shielding element. Due to its conductivity, when it is combined with the electrical signal transmission component 20, it is necessary to control the electrical insulation between the electromagnetic shielding element 40 and the electrical signal transmission component 20. Therefore, an insulating layer 60 can be provided between the electromagnetic shielding element 40 and the electrical signal transmission component 20 to electrically insulate and separate the electromagnetic shielding element 40 and the electrical signal transmission component 20. Of course, in some embodiments, other insulating connecting supports (such as insulating rods) can be used to insulate and separate the electromagnetic shielding element 40 and the electrical signal transmission component 20. The electromagnetic shielding element 40 can be configured as any one of a metal shielding layer, a carbon nanotube shielding layer, a ferrite shielding layer, and a graphene shielding layer. The metal shielding layer can be made of at least one of platinum and gold and can be formed by at least one of sputtering, evaporation, and chemical vapor deposition. The insulating layer 60 can be made of at least one of polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8.

[0100] In this embodiment, the first electromagnetic shielding component 41 and the second electromagnetic shielding component 42 are metal platinum shielding layers, and the conductive connecting portion 43 is made of the same material as the second electromagnetic shielding component 42; an insulating layer 60 made of polyimide is provided between the electromagnetic shielding component 40 and the electrical signal transmission component 20, as shown in Figures 4 to 5, 9 and 11. The insulating layer 60 includes a first insulating layer 61 and a second insulating layer 62. The first insulating layer 61 is provided between the first electromagnetic shielding component 41 and the electrical signal transmission component 20, and the second insulating layer 62 is provided between the second electromagnetic shielding component 42 and the electrical signal transmission component 20. Through holes 63 are provided on the first insulating layer 61 and the second insulating layer 62 corresponding to the conductive connecting portion 43 on the second electromagnetic shielding component 42, and the conductive connecting portion 43 on the second electromagnetic shielding component 42 is connected to the first electromagnetic shielding component 41 through the through holes 63.

[0101] Additionally, in some embodiments, the electromagnetic shielding element 40 may be configured to include an insulating layer and a conductive layer. The insulating layer is laminated to the electrical signal transmission component 20, and the conductive layer is disposed on a surface of the insulating layer facing away from the electrical signal transmission component 20. Electromagnetic shielding is primarily achieved through the conductive layer, while the insulating layer provides electrical insulation between the conductive layer and the electrical signal transmission component 20 and serves as a connecting support between the conductive layer and the electrical signal transmission component 20. The conductive layer may be selected from any one of a metal layer, a carbon nanotube layer, a ferrite layer, and a graphene layer. The insulating layer may be made of at least one of polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8.

[0102] In order to ensure that the electromagnetic shielding component 40 effectively prevents interference with the signal transmitted by the electrical signal transmission component 20, the outer contour size of the electromagnetic shielding component 40 is generally designed to be greater than or equal to the size of the corresponding electrical signal transmission component 20 along the center direction of the main frame 10, and the corresponding setting position area of ​​the electrical signal transmission component 20 on the main frame 10 can be regarded as constituting an electrical signal transmission component assembly part, and the electromagnetic shielding component 40 protects the electrical signal transmission component 20. Furthermore, in order to improve the stability of the structural setting, it can be designed that the outer contour size of the electrical signal transmission component assembly part along the center direction of the main frame 10 is equal to or greater than the outer contour size of the corresponding area on the electromagnetic shielding component 40. Specifically, the electrical signal transmission component assembly part includes an electrode assembly part and a wire assembly part. The electrode assembly part is composed of the corresponding setting position area of ​​the electrode 21 in the electrical signal transmission component 20 on the main frame 10, and the wire assembly part is composed of the corresponding setting position area of ​​the wire 22 in the electrical signal transmission component 20 on the main frame 10. It can be designed that, along the direction toward the center of the main frame 10, the outer contour dimension of the electrode assembly part is equal to or greater than the outer contour dimension of the corresponding area on the electromagnetic shielding component 40, and the outer contour dimension of the wire assembly part is equal to or greater than the outer contour dimension of the corresponding area on the electromagnetic shielding component 40. Furthermore, the outer contour of the assembly portion of the electrical signal transmission assembly on the main frame 10 can be designed to be the same as the outer contour of the corresponding area on the electromagnetic shielding component 40, and the outer contour size of the assembly portion of the electrical signal transmission assembly can be equal to or slightly larger than the outer contour size of the corresponding area on the electromagnetic shielding component 40. Alternatively, the outer contour of the assembly portion of the electrical signal transmission assembly on the main frame 10 can be designed to be different from the outer contour of the corresponding area on the electromagnetic shielding component 40, and the outer contour size of the assembly portion of the electrical signal transmission assembly on the main frame 10 can be larger than the outer contour size of the corresponding area on the electromagnetic shielding component 40. That is, along the radial direction of the main frame 10, the outer contour of the area corresponding to the location of the electrical signal transmission assembly 20 on the main frame 10 is larger than the outer contour of the corresponding area on the electromagnetic shielding component 40. With the above structural design, the main frame 10 can fully support the electrical signal transmission assembly 20 and the electromagnetic shielding component 40, further improving the stability of the structure.

[0103] In some embodiments, an electrical signal transmission component assembly groove may be provided on the electrical signal transmission component assembly portion of the main frame 10, and the electrical signal transmission component 20 may be assembled in the electrical signal transmission component assembly groove. In some embodiments where an electromagnetic shielding member 40 is provided between the electrical signal transmission component 20 and the main frame 10, the electrical signal transmission component 20 may be assembled in the electrical signal transmission component assembly groove, and an electromagnetic shielding member 40 may also be provided between the electrical signal transmission component 20 and the main frame 10. With this structural arrangement, the electrical signal transmission component 20 may be installed in the electrical signal transmission component assembly groove, which may reduce the thickness of the structure on the one hand, and on the other hand, the sidewalls of the electrical signal transmission component assembly groove may limit the electrical signal transmission component 20, preventing displacement of the electrical signal transmission component 20 during use, thereby further improving the structural stability.

[0104] As shown in Figures 1, 4, 5 and 13, the vascular interventional medical device of this embodiment further includes an insulating packaging layer 30. The insulating packaging layer 30 is arranged on the outermost layer of the main frame 10 on the side where the electrical signal transmission component 20 is provided, and exposes at least a portion of the electrode 21, thereby playing the role of insulation, packaging and protection. Specifically, a through hole can be opened on the insulating packaging layer 30 corresponding to the position where the electrode 21 is provided to expose at least a portion of the electrode 21. The material of the insulating packaging layer 30 can be selected from at least one of polyimide (PI), polydimethylsiloxane (PDMS), poly(p-phenylene benzobisoxazole) (PBO), and SU8.

[0105] In some embodiments, the insulating encapsulation layer 30 may be omitted. For example, when an electromagnetic shielding member 40 is provided on the side of the electrical signal transmission component 20 facing away from the main frame 10, the electromagnetic shielding member 40 located on the side of the electrical signal transmission component 20 facing away from the main frame 10 can provide a certain degree of encapsulation and protection for the electrical signal transmission component 20, thereby eliminating the need for the insulating encapsulation layer 30. Situations in which the electromagnetic shielding member 40 is provided on the side of the electrical signal transmission component 20 facing away from the main frame 10 include: the electromagnetic shielding member 40 is provided on the side of the electrical signal transmission component 20 facing away from the main frame 10, covering the conductive wires 22 and exposing at least a portion of the electrodes 21; or the electromagnetic shielding member 40 is provided between the electrical signal transmission component 20 and the main frame 10, as well as on the side of the electrical signal transmission component 20 facing away from the main frame 10, covering the conductive wires 22 and exposing at least a portion of the electrodes 21; or the electromagnetic shielding member 40 is provided around the electrical signal transmission component 20, exposing at least a portion of the electrodes 21.

[0106] In addition, in some embodiments, in order to improve the safety of the vascular interventional medical device implantation process, the vascular interventional medical device may further include a buffering and protective component, which is configured to reduce the risk of puncturing a blood vessel during the implantation process of the vascular interventional medical device. Specifically, the buffering and protective component may be disposed at the implantation front end of the vascular interventional medical device. In addition, the buffering and protective component may be designed to have an arc-shaped buffering surface at the front end of the intervention deployment. For example, the buffering and protective component may be designed to be spherical, semi-spherical, ellipsoidal, semi-ellipsoidal, etc. By designing the arc-shaped buffering surface at the front end of the intervention deployment of the buffering and protective component, it can play an effective buffering and protective role during the deployment and implantation of the blood vessel, thereby reducing the risk of puncturing the blood vessel.

[0107] In some embodiments, the above-mentioned vascular interventional medical device can be used in conjunction with an external delivery component during deployment to deploy the vascular interventional diagnostic and treatment device to the target site in the blood vessel. Of course, in some embodiments, the vascular interventional diagnostic and treatment device can also be designed to include a delivery component, which is configured to deploy and implant the vascular interventional diagnostic and treatment device into the blood vessel. The delivery component can be a delivery shaft, which can be configured to pass through the main frame 10, and one end of the delivery shaft can be connected to the deployment front end of the main frame 10 or a buffer protection component provided at the deployment front end of the main frame 10.

[0108] The above-mentioned vascular interventional medical device can be applied to a vascular interventional medical system, and the present invention further proposes a vascular interventional medical system, which includes any of the above-mentioned vascular interventional medical devices. Specifically, one end of the wire 22 of the electrical signal transmission component 20 in the vascular interventional medical device is connected to the electrode 21 on the electrical signal transmission component 20, and the wire 22 extends along the side wall of the main frame 10 and is configured to be led out and electrically connected to an external device. The external device can be equipped as needed. For example, in some embodiments, the external device is only used to receive signal data detected by the electrode and transmitted through the wire; or, in some embodiments, in addition to receiving signal data detected by the electrode and transmitted through the wire, the external device can also process it to obtain target signal data; or, in some embodiments, in addition to receiving and processing signal data transmitted by the vascular interventional diagnosis and treatment device, the external device can further generate a control signal and transmit the control signal to other devices; or, the external device can be a driving power supply to apply electrical stimulation to the vascular wall cells through the wire and electrode; in addition, other external devices can be configured as needed.

[0109] In addition, the above-mentioned vascular interventional medical system can also be used to construct in vitro cultured cell constructs, electrical signal acquisition cell constructs, and electrical stimulation cell constructs. Furthermore, the present application also proposes the application of more than one vascular interventional medical system in constructing in vitro cultured cell constructs, electrical signal acquisition cell constructs, or electrical stimulation cell constructs.

[0110] The above-described embodiments merely illustrate several implementations of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the spirit of the present invention, and all such variations and improvements fall within the scope of protection of the present invention.

Claims

1. A vascular interventional medical device, characterized in that: include: A main frame, wherein the main frame is an elastic support frame; An electrical signal transmission component, the electrical signal transmission component is arranged on the main frame, and comprises an electrode and a wire, wherein the wire is electrically connected to the electrode; An electromagnetic shielding component is configured to reduce or block interference of external electromagnetic signals on the electrical signal transmitted by the electrical signal transmission component.

2. The vascular interventional medical device according to claim 1, characterized in that: The electromagnetic shielding member is provided on at least one side of the electrical signal transmission component; Preferably, the electromagnetic shielding element is arranged in any one of the following ways: Arrangement method 1: the electromagnetic shielding member is arranged on a side of the electrical signal transmission component away from the main frame, covering the wire and exposing at least part of the electrode; Arrangement mode 2: the electromagnetic shielding member is arranged between the electrical signal transmission component and the main frame; Arrangement mode three: the electromagnetic shielding member is arranged between the electrical signal transmission component and the main frame, and is arranged on a side of the electrical signal transmission component away from the main frame, covering the wire and exposing at least part of the electrode; Arrangement method four: the electromagnetic shielding component is arranged around the electrical signal transmission component and exposes at least part of the electrode.

3. The vascular interventional medical device according to claim 2, characterized in that: An insulating layer is provided between the electromagnetic shielding component and the electrical signal transmission component; Preferably, the electromagnetic shielding member is selected from any one of a metal shielding layer, a carbon nanotube shielding layer, a ferrite shielding layer, and a graphene shielding layer; preferably, the material of the metal shielding layer is selected from at least one of platinum and gold; Preferably, the material of the insulating layer is selected from at least one of polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8.

4. The vascular interventional medical device according to claim 1, characterized in that: The electrical signal transmission component is configured by a conductive material layer; preferably, the electrode and the wire are in an integrated structure; Preferably, the conductive material layer is a metal material layer, a non-metallic conductive material layer, or a composite layer of a non-metallic conductive material layer and a metal material layer; Preferably, the conductive material layer comprises a non-precious metal conductive base layer and a precious metal protective layer, the non-precious metal conductive base layer is arranged on the surface of the main frame, and the precious metal protective layer covers the non-precious metal conductive base layer; the material of the precious metal protective layer is selected from at least one of platinum and gold; Preferably, the thickness of the conductive material layer is less than 5 μm.

5. The vascular interventional medical device according to claim 1, characterized in that: The main frame is configured to be contractible and expandable along a central axis; Preferably, the main frame is in the shape of a hollow tube; Preferably, the side wall of the main frame is a mesh structure; Preferably, the electrodes are arranged at the intersection of the mesh structures on the main frame; Preferably, there are two or more electrodes; Preferably, the electrodes are evenly arranged along the radial direction and / or the axial direction of the main frame; Preferably, the surface of the electrode is provided with a modification layer, and the modification layer has a biological signal recognition function, which is used to recognize and detect changes in biological signals in blood vessels, and convert the changes in the biological signals into readable electrical signals through the electrode and transmit them to an external circuit; the biological signals include chemical signals and / or physical signals related to the physiological condition of the organism; Preferably, the material of the modification layer is selected from at least one of enzymes, redox mediators, nanomaterials, antibodies, biotin, nucleic acid aptamers, polymers, ion carriers, and piezoelectric materials; Preferably, the enzyme is selected from at least one of oxidoreductase, transferase, hydrolase, lyase, ligase and isomerase; Preferably, the oxidoreductase is selected from the group consisting of glucose oxidase, glutamate oxidase, alcohol oxidase, lactate oxidase, amino acid oxidase, cholesterol oxidase, choline oxidase, nicotinamide adenine dinucleotide phosphate oxidase, oxalate oxidase, cytochrome oxidase, bilirubin oxidase, serotoninase, galactose oxidase, glucose dehydrogenase, lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, glutamate dehydrogenase, pyruvate dehydrogenase, sorbitol dehydrogenase, formate dehydrogenase, cellobiose dehydrogenase, amino acid dehydrogenase, succinate dehydrogenase, catalase, horseradish peroxidase, lactoperoxidase, glutathione peroxidase, at least one of: a biotinylated enzyme, an ascorbate peroxidase, a soybean peroxidase, a cytochrome peroxidase, a thyroid peroxidase, a myeloperoxidase, a superoxide dismutase, a haloperoxidase, a thiol peroxidase, a 5α reductase, a 5β reductase, an aldehyde reductase, an aldose reductase, a hydroxymethylglutaryl-CoA reductase, a methemoglobin reductase, a ribonucleotide reductase, a nitroreductase, a thioredoxin reductase, a dihydrofolate reductase, a disulfide reductase, a sulfite reductase, a cytochrome reductase, an imine reductase, a fumarate reductase, a carboxylic acid reductase, and a dimethyl sulfoxide reductase; Preferably, the transferase is selected from at least one of glutathione transferase, acetyltransferase, methyltransferase, transketolase, transaldolase, glycosyltransferase, transketolase, amino acid transferase and acyltransferase; Preferably, the hydrolase is selected from at least one of lipase, phosphohydrolase, glycoside hydrolase, acetylhydrolase, nucleotide hydrolase, helicase, peptide hydrolase, urease and creatinine deiminase; Preferably, the lyase is selected from at least one of a decarboxylase, a dehydrogenase, a dehalogenase, an aspartate ammonia lyase, and a cysteine ​​desulfurase; Preferably, the ligase is selected from at least one of tRNA synthetase, succinyl coenzyme A synthetase, amino acid ligase, DNA ligase, RNA ligase, and carboxylase; Preferably, the isomerase is selected from at least one of a racemase, an epimerase, and a mutase; Preferably, the nanomaterial is selected from at least one of metal nanomaterials, nanoceramics, nanoglass, and nanopolymer materials; Preferably, the antibody is selected from at least one of C-reactive protein antibody, thyrotropin antibody, bilirubin antibody, albumin antibody, carcinoembryonic antigen antibody, alpha-fetoprotein antibody, prostate-specific antigen antibody, cancer antigen 125 antibody, and cortisol antibody; Preferably, the nucleic acid aptamer is selected from at least one of a DNA type oligonucleotide chain and an RNA type oligonucleotide chain; Preferably, the polymer is selected from at least one of polyaniline, polypyrrole, polyacetylene, polycarbazole, polythiophene, polyphenylene methylene, poly(3,4-ethylenedioxythiophene), polystyrene sulfonic acid, chitin, chitosan, polyvinyl chloride, polyvinyl butyral, and Nafion; Preferably, the ion carrier is selected from potassium ions, sodium ions, calcium ions, magnesium ions, iron ions, zinc ions, manganese ions, At least one of ions, copper ions, molybdenum ions, cobalt ions, cobalt ions, chromium ions, chloride ions, sulfate ions, and phosphate ions; Preferably, the piezoelectric material is selected from at least one of single crystal piezoelectric ceramics, polycrystalline piezoelectric ceramics, piezoelectric polymers, and polymer-piezoelectric ceramic composites.

6. The vascular interventional medical device according to claim 1, characterized in that: The area on the main frame corresponding to the location where the electrical signal transmission component is set constitutes an electrical signal transmission component assembly portion, and along the direction toward the center of the main frame, the outer contour size of the electrical signal transmission component assembly portion is equal to or greater than the outer contour size of the area corresponding to the electromagnetic shielding component; Preferably, an electrical signal transmission component assembly groove is provided on the electrical signal transmission component assembly portion, and the electrical signal transmission component is assembled in the electrical signal transmission component assembly groove.

7. The vascular interventional medical device according to any one of claims 1 to 6, characterized in that: The material of the main frame is selected from degradable polymer materials; Alternatively, the material of the main frame is selected from at least one of shape memory alloy and iron, and a dielectric layer is provided on the surface of the main frame, and the dielectric layer is provided toward one side of the electrical signal transmission component; Preferably, the material of the dielectric layer is selected from at least one of polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8; Preferably, the shape memory alloy is selected from at least one of Nitinol alloy, cobalt-chromium alloy and magnesium alloy.

8. The vascular interventional medical device according to any one of claims 1 to 6, characterized in that: It also includes an insulating packaging layer, which is arranged on the outermost layer of the main frame on one side of the electrical signal transmission component and exposes at least part of the electrode; preferably, the material of the insulating packaging layer is selected from at least one of polyimide, polydimethylsiloxane, poly(p-phenylene benzobisoxazole), and SU8; Preferably, it further comprises a buffer protection component, which is arranged at the implantation front end of the vascular intervention medical device and is configured to reduce the risk of puncturing a blood vessel during the implantation process of the vascular intervention medical device; Preferably, the apparatus further comprises a delivery component configured to deploy and implant the vascular intervention medical device into a blood vessel.

9. A vascular interventional medical system, characterized in that: A vascular interventional medical device comprising any one of claims 1 to 8.

10. Use of the vascular interventional medical system according to claim 9 in constructing an in vitro cultured cell construct, an electrical signal acquisition cell construct or an electrical stimulation cell construct.

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