Devices and methods for diagnosis and therapeutic treatment of acute compartment syndrome

Abstract

A method for treatment is provided, including providing i) an implantable continuous compartment pressure monitor and ii) an implantable energy emitter; implanting and operating the continuous compartment pressure monitor to monitor a compartment pressure; and implanting the energy emitter and operating the energy emitter in order to cause cell electroporation.

Description

Devices and Methods for Diagnosis and Therapeutic Treatment of Acute Compartment Syndrome

[0001] The present application claims priority from U.S. provisional patent application No. 63 / 520,886 filed on August 21, 2023, incorporated herein by reference.TECHNICAL FIELD

[0002] The present disclosure relates to the field of medical devices.BACKGROUND

[0003] Acute Compartment Syndrome (ACS) is a hard-to-diagnose and serious condition, characterized by dangerously elevated pressure within an enclosed muscular compartment. The standard of care is to diagnose ACS via clinical symptoms including pain or the palpated tension in the limb, criteria which are unreliable and inherently subjective. Furthermore, the outcome of ACS is directly related to the time elapsed between diagnosis and definitive treatment. If left untreated for only a few hours, ACS can lead to tissue necrosis, severe intractable pain, paralysis, sensory deficits, long-term disability, or even death. However, the most common treatment for ACS is a highly invasive surgery known as a fasciotomy, where the pressure of the affected compartment is surgically relieved by cutting open the surrounding fascia. Surgical site infections, blood loss, need for further surgery for delayed wound closure or skin grafting, reduced limb function and long recovery times are all known secondary effects of fasciotomy.SUMMARY

[0004] Acute Compartment Syndrome (ACS) is a serious condition affecting pressure in a muscle compartment, see for example Via AG, Oliva F, Spoliti M, Maffulli N. Acute compartment syndrome. Muscles Ligaments Tendons J. 2015 Mar 27;5(1): 18-22. After positive diagnostic of ACS, the current medical therapy is surgically based (fasciotomy) with little options for minimally invasive solutions. There is a high risk of secondary complications with fasciotomies, thus a minimally invasive therapeutic approach to treating ACS which would eliminate the need for fasciotomy would be desirable.

[0005] A broad aspect is a method for treatment of acute compartment syndrome. The method includes providing an implantable continuous compartment pressure monitor and an implantable energy emitter; implanting and operating the continuous compartment pressure monitor to monitor a compartment pressure; and implanting the energy emitter and operating the energy emitter in order to cause cell electroporation.

[0006] In some embodiments, the method may include providing, implanting and operating a fluid drainage pump, wherein the fluid drainage pump is configured to remove fluid from the compartment.

[0007] In some embodiments, the fluid drainage pump may be included in the same device as the implantable energy emitter.

[0008] In some embodiments, the fluid drainage pump may be included in the same devices as the continuous compartment pressure monitor.

[0009] In some embodiments, the fluid drainage pump may be included in the same devices as the continuous compartment pressure monitor and the implantable energy emitter.

[0010] In some embodiments, the continuous compartment pressure monitor and the implantable energy emitter may be configured to be implanted through the same incision.

[0011] In some embodiments, the operation of the energy emitter may be configured to cause more reversible cell electroporation than irreversible cell electroporation in the compartment.

[0012] In some embodiments, the method for treatment may include hyperbaric oxygen therapy during one or both of i) the perioperative and ii) postoperative period.

[0013] In some embodiments, the method for treatment further may include providing a negative or reduced pressure environment during one or both of i) the perioperative and ii) postoperative period.

[0014] In some embodiments, the method may include providing a negative or reduced pressure environment during one or both of i) the perioperative and ii) postoperative period.

[0015] In some embodiments, the energy emitter may be operatively connected to the continuous compartment pressure monitor and a device configured to provide diastolic pressure and is configured to either i) provide an alert or ii) automatically turn on if delta pressure is equal or lessthan a second threshold value.

[0016] In some embodiments, the method for treatment may be configured to i) diagnose and ii) provide minimally invasive treatment for acute compartment syndrome.

[0017] In some embodiments, the method for treatment further may include operating the energy emitter in order to cause cell electroporation while a surgical fasciotomy is simultaneously occurring.

[0018] Another broad aspect is a device including an implantable energy emitter which is configured to cause mostly reversible cell electroporation when operated within a compartment.

[0019] In some embodiments, the device may include a fluid drainage pump which is configured to remove fluid from the compartment.

[0020] In some embodiments, the device further may include a continuous compartment pressure monitor configured to monitor a compartment pressure.

[0021] In some embodiments, the device further may include the fluid drainage pump and the continuous compartment pressure monitor.

[0022] In some embodiments, the energy emitter may be operatively connected to the continuous compartment pressure monitor and is configured to either i) provide an alert or ii) automatically turn on if the compartment pressure is equal or greater than a first threshold value.

[0023] In some embodiments, the energy emitter may be operatively connected to the continuous compartment pressure monitor and a device configured to provide diastolic pressure and is configured to either i) provide an alert or ii) automatically turn on if delta pressure is equal or less than a second threshold value.

[0024] In some embodiments, the device may be configured to be sufficiently small such that it may be inserted into a compartment via a single incision.

[0025] In some embodiments, the device may be configured to be repeatedly sterilizable.

[0026] Another broad aspect is an implantable device for performing cell electroporation of a subject for treating acute compartment syndrome of the subject. The implantable device includes a power source; an energy emitter configured to receive power from the power source and to emit energy for performing the cell electroporation; a controller configured to receive input for causingcell electroporation; and generate a command for causing the energy emitter to emit the energy for performing the cell electroporation; and a housing for containing at least the controller.

[0027] In some embodiments, the device may include a puncture device for implanting the implantable device into the subject.

[0028] In some embodiments, the device may include a pressure sensor, wherein the controller is further configured to receive pressure readings from the pressure monitor; and one of cause a transmission of the pressure readings to an external computer; and determine a presence of acute compartment syndrome from the pressure readings.

[0029] Another broad aspect is a kit comprising the implantable device as defined herein; and an implantable pressure monitor for generating pressure readings of tissue of a subject surrounding the pressure monitor once implanted into the subject.

[0030] Another broad aspect is an implantable device for performing cell electroporation of a subject for treating acute compartment syndrome of the subject, including a power source; an energy emitter configured to receive power from the power source and to emit energy for performing the cell electroporation; a controller configured to: receive input for causing cell electroporation; and generate a command for causing the energy emitter to emit the energy for performing the cell electroporation; and a housing for containing at least the controller.

[0031] In some embodiments, the device may include a puncture device for implanting the implantable device into the subject.

[0032] In some embodiments, the device may include a pressure monitor, wherein the controller may be further configured to receive pressure readings from the pressure monitor; and one of: cause a transmission of the pressure readings to an external computer, wherein a command received from the external computer to cause cell electroporation is the received input; and determine a presence of acute compartment syndrome from the pressure readings, wherein the pressure readings is the received input.

[0033] In some embodiments, the energy emitter may be operatively connected to the pressure monitor and a device configured to provide a diastolic pressure and may be configured to i) provide an alert or ii) causing a turning on of the device configured to provide a diastolic pressure if a delta pressure is equal or less than a second threshold value.

[0034] In some embodiments, the controller may be further configured to: receive a compartment pressure from the pressure monitor and compare the received compartment pressure with a threshold value; and cause the energy emitter to perform cell electroporation if the compartment pressure is greater than the threshold value.

[0035] In some embodiments, the device may include a fluid drainage pump that may be configured to remove fluid from a muscular compartment that is suffering from acute compartment syndrome.

[0036] In some embodiments, a size of the device may be adapted for inserted into a muscular compartment via a single incision.

[0037] In some embodiments, the device may be configured to be repeatedly sterilizable.

[0038] In some embodiments, the energy emitter may be configured to perform pulse field ablation.

[0039] In some embodiments, the energy emitter may be configured to perform cell electroporation using a pulsed electro-magnetic field.

[0040] In some embodiments, the device may include an input / output interface for transmitting over a wireless connection pressure readings or an alert of a pressure of acute compartment syndrome to an external computer.

[0041] In some embodiments, the wireless connection may be a BluetoothTM connection.

[0042] Another broad aspect is a kit comprising the implantable device as defined herein; and an implantable pressure monitor for generating pressure readings of tissue of a subject surrounding the pressure monitor once implanted into the subject.

[0043] Another broad aspect is a method for treatment, comprising providing i) an implantable continuous compartment pressure monitor and ii) an implantable energy emitter;

[0044] implanting and operating the continuous compartment pressure monitor to monitor a compartment pressure; and implanting the energy emitter and operating the energy emitter in order to cause cell electroporation.

[0045] Another broad aspect is use of an energy emitter implantable into a muscular compartment for treating acute compartment syndrome by performing cell electroporation.BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Embodiments of the disclosure will be described by way of example only with reference to the accompanying drawings, in which:

[0047] Figure l is a block diagram of an exemplary device for diagnosis and treatment of acute compartment syndrome;

[0048] Figure 2 is a block diagram of an exemplary device for treatment of acute compartment syndrome; and

[0049] Figure 3 is a flowchart diagram of an exemplary method of treating acute compartment syndrome.DETAILED DESCRIPTION

[0050] After positive diagnosis of ACS, current medical therapy is surgically based with little options for minimally invasive solutions. This disclosure provides methods and devices to allow the muscle to be treated using an implantable energy emitter (e.g. pulsed energy emitter), such as PFA (Pulsed Field Ablation), PEMF (Pulsed Electro-Magnetic Field), PRFE (Pulsed Radio- Frequency Energy) to treat ACS in a minimally invasive manner.

[0051] In one embodiment, a method for treatment includes: providing i) an implantable continuous compartment pressure monitor, see for example US 11,633,212 and ii) an implantable energy emitter; implanting and operating the continuous compartment pressure monitor to monitor a compartment pressure; and implanting the energy emitter and operating the energy emitter in order to cause cell electroporation.

[0052] Herein and throughout this disclosure an implantable energy emitter refers to a device, either single use or reusable with sterilization, which is configured to provide energy pulses sufficient to cause cell electroporation. The cell electroporation may be reversible or irreversible. The electrical pulses may be PFA, PEMF, PRFE or other approaches now known or later developed.

[0053] In some embodiments, the method for treatment further includes providing, implanting and operating a fluid drainage pump, wherein the fluid drainage pump is configured to remove fluid from the compartment.

[0054] In some further embodiments, the fluid drainage pump is included in the same device as the implantable energy emitter.

[0055] In some further embodiments, the fluid drainage pump is included in the same devices as the continuous compartment pressure monitor.

[0056] In some further embodiments, the fluid drainage pump is included in the same devices as the continuous compartment pressure monitor and the implantable energy emitter.

[0057] In some embodiments, the continuous compartment pressure monitor and the implantable energy emitter are configured to be implanted through the same incision.

[0058] In some embodiments, the operation of the energy emitter is configured to cause more reversible cell electroporation than irreversible cell electroporation in the compartment.

[0059] In some embodiments, the method for treatment further includes providing hyperbaric oxygen therapy during one or both of i) the perioperative and ii) postoperative period.

[0060] In some embodiments, the method for treatment further includes providing a negative or reduced pressure environment during one or both of i) the perioperative and ii) postoperative period.

[0061] In some embodiments, the energy emitter is operatively connected to the continuous compartment pressure monitor and is configured to either i) provide an alert or ii) automatically turn on if the compartment pressure is equal or greater than a first threshold value. Herein and throughout this disclosure, operatively connected means connected such that information may be exchanged, via either wireless communication, wired communication, computer software designed to exchange information with the cloud, or other methods now known or later developed. The first threshold value may be approximately 30 mmHg.

[0062] In some embodiments, the energy emitter is operatively connected to the continuous compartment pressure monitor and a device configured to provide diastolic pressure and is configured to either i) provide an alert or ii) automatically turn on if delta pressure is equal or less than a second threshold value. Herein and throughout the disclosure, delta pressure is equal to diastolic pressure minus the compartment pressure. The second threshold value may be approximately 30 mmHg, approximately 25 mmHg or approximately 20 mmHg.

[0063] In some embodiments, the method for treatment is configured to i) diagnose and ii) provideminimally invasive treatment for acute compartment syndrome.

[0064] In some embodiments, the method for treatment further includes operating the energy emitter in order to cause cell electroporation while a surgical fasciotomy is simultaneously occurring.

[0065] In one embodiment a device is provided, including; an implantable energy emitter which is configured to cause reversible cell electroporation when operated within a compartment.

[0066] In some embodiments the device further includes a fluid drainage pump which is configured to remove fluid from the compartment.

[0067] In some embodiments the device further includes a continuous compartment pressure monitor configured to monitor a compartment pressure.

[0068] In some further embodiments the device further includes the fluid drainage pump and the continuous compartment pressure monitor.

[0069] In some embodiments, the energy emitter is operatively connected to the continuous compartment pressure monitor and is configured to either i) provide an alert or ii) automatically turn on if the compartment pressure is equal or greater than a first threshold value.

[0070] In some embodiments, the energy emitter is operatively connected to the continuous compartment pressure monitor and a device configured to provide diastolic pressure and is configured to either i) provide an alert or ii) automatically turn on if delta pressure is equal or less than a second threshold value.

[0071] In some embodiments, the device is configured to be sufficiently small such that it may be inserted into a compartment via a single incision.

[0072] In some embodiments, the device is configured to be repeatedly sterilizable.

[0073] EXEMPLARY IMPLANTABLE DEVICE FOR TREATING ACUTE COMPARTMENT SYNDROME:

[0074] Reference is now made to Figure 1, illustrating an exemplary implantable device 100 for treating acute compartment syndrome, along with generating information indicative of a presence of acute compartment syndrome (i.e. for diagnostic purposes). However, it will be understood that the implantable device may be configured to treat acute compartment syndrome without alsoproviding information indicative of a presence of acute compartment syndrome, as illustrated in Figure 2.

[0075] The device 100 includes a power source 108, a controller 101, an energy emitter 102, an input interface or input / output (I / O) interface 103 and a housing 105. In some instances, the device 100 may include a puncture device 106. In some instances, the device 100 may include a pressure monitor 104.

[0076] The puncture device 106 is for implanting the device 100 in tissue of a subject (under the skin of a subject), as described, for instance, in U.S. Patent No. 11,633,212, incorporate herein by reference. An exemplary puncture device 106 for implanting the device in tissue of a subject may be a needle assembly joined to the housing 105. In some instances, the puncture device 106 may be separate from the device 100. The puncture device 106 may be joinable to the device 100 for purposes of inserting the device 100 into the subject. The puncture device 106 may include a blunt tip suitable for blunt dissection, wherein a surgical incision is made through one or both of i) the skin and ii) the fascia, and the puncture device 106 is designed to push through fatty layers, muscle etc.

[0077] The power source 108 provides power to the rest of the device 100. An exemplary power source 108 may be a battery (e.g. a rechargeable battery, a single-use battery), a chord or connection for receiving power from an external power source (e.g. power outlet), etc.

[0078] The controller 101 is configured to receive data from the pressure monitor 104 and interface 103, and to generate commands to activate the energy emitter 102 to cause cell electroporation. The controller 101 may be or may include a microprocessor. The controller may include a processor and memory (memory storing program code that, when executed by the processor, causes the processor to performs certain actions such as receiving and processing data from the pressure monitor 104, receiving and processing data received at the interface 103, generating commands to activate the pulse energy emitter 102, etc.) The memory may be non-transitory.

[0079] The I / O interface 103 or input interface 103 receives data from, and optionally transmits data to, an external computer. The I / O interface 103 may be a receiver, a transceiver, etc. The I / O interface 103 is in communication with the controller 101. The I / O interface 103 may include a network interface and may be a wired or wireless interface for establishing a remote connection with the remote computer 150. For instance, the I / O interface 103 may be short-range wirelesstransceiver (e.g. a Bluetooth™ transceiver).

[0080] The pressure monitor 104 is configured to detect a pressure or increase in pressure in tissue of the subject, where the pressure or increase of pressure may be indicative of acute compartment syndrome. The pressure monitor 104 may be a pressure monitor as is known in the art. Exemplary pressure monitors are described, for instance, in U.S. Patent No. 11,633,212.

[0081] The energy emitter 102 (e.g. pulse energy emitter) generates energy for purposes of performing cell electroporation, following receipt of a signal or command from the controller 101 for causing a generation of energy. The energy emitter 102 may generate pulsed energy (e.g. through a transducer and an alternating current converter). As such, the energy emitter 102 may generate energy for performing PFA (Pulsed Field Ablation), PEMF (Pulsed Electro-Magnetic Field), PRFE (Pulsed Radio-Frequency Energy), to perform cell electroporation and treat the acute compartment syndrome without requiring more invasive surgery. In some examples, the energy emitter 102 may generate a continuous source of energy (however, certain properties of the outputted energy or energy source may have to be modified to not overly damage the targeted, or surrounding, tissue of the subject).

[0082] The housing 105 houses and protects some or all of the other components of the device 100 (such as the power source 108, the interface 103, the energy emitter 102 and / or the pressure monitor 104). The housing 105 houses the controller. In some embodiments, an opening may be provided in the housing 105 for exposing at least a part of the pressure monitor 104 to an external environment (e.g. tissue of the subject) for the purpose of generating a pressure reading of the external environment. In some instances, the energy emitter 102 may be positioned on an outside of the housing 105, or an opening may be provided in the housing 105 to enable the energy emitted by the energy emitter 102 to reach the target tissue of the subject for treatment of the subject. The puncture device 106 may be entirely or partially located outside of the housing 105. The puncture device 106 is joined or joinable to the housing 105 (e.g. a connector may be present on the housing105 or puncture device 106 for connecting the housing 105 to the puncture 106 for insertion of the device 100 into the patient. Once the device 100 is inserted into the patient, the puncture device106 may detach from the housing 105, and thereby removed from the patient following the insertion of the device 100).

[0083] As shown in Figure 2, in some instances, the device 100 may not include the pressuremonitor 104, thereby not functioning to detect an increase in compartment pressure (or a decrease in delta pressure) indicative of acute compartment syndrome. In some instances, the pressure monitor 104 may be a separate device capable of wirelessly connecting to the I / O interface 103, which may be repeatedly moved and inserted into one or more compartments as desired.

[0084] In some instances, an external computer 150 may be provided. The external computer 150 communicates with the implantable device 100 via the I / O interface 103. The external computer 150 may be a desktop computer, a laptop computer, a smartphone, a tablet computer, etc. The external computer 150 may receive pressure readings generated by the pressure monitor 104 of the implantable device 100. The external computer 150 may run a client application program (e.g. the client application program running through a web browser or including program code stored in memory of the external computer 150) for analyzing the received pressure readings and determine a presence of acute compartment syndrome. In some instances, the pressure readings are displayed, via the client application program, on a display of the external computer 150, where an operator determines if the patient has acute compartment syndrome based from the received pressure readings. When a determination of a presence of acute compartment syndrome has been made, the external computer 150, running the client application program, may generate a command, transmitted to the I / O interface 103 of the implantable sensor 100, for causing the controller 101 to cause the energy emitter 102 to begin cell electroporation.

[0085] EXEMPLARY METHOD OF TREATING ACUTE COMPARTMENT SYNDROME USING AN IMPLANTABLE DEVICE:

[0086] Reference is now made to Figure 3, illustrating an exemplary method 300 of treating acute compartment syndrome in a subject using an implantable device. The implantable device may be implantable device 100, or any other implantable device in accordance with the present teachings.

[0087] The implantable device is provided at step 310. The implantable device includes an energy emitter. In some examples, the implantable device includes a pressure monitor. An exemplary implantable device is device 100.

[0088] The implantable device is implanted into the subject at step 320. The implantable device may be implanted into the subject using a puncture device, where the puncture device punctures the skin or membrane (and in some examples the muscle) of the subject, the puncture device providing an opening for implanting the implantable device into tissue of the subject.Alternatively, the implantable device may be implanted into the subject via a surgical incision.

[0089] In some instances, the implantable device may monitor the pressure of the surrounding tissue of the subject. The pressure readings may be communicated to an external computer. The pressure readings are indicative of the presence or absence of acute compartment syndrome in the corresponding tissue of the subject.

[0090] It will be understood that, in some examples, a device, separate from (but possibly in wireless communication with) the implantable device for treating the subject from acute compartment syndrome, may be provided for monitoring the pressure of the tissue of the subject and implanted separately into the subject.

[0091] The implantable device is then caused to perform cell electroporation when acute compartment syndrome is determined to be present (e.g. following a diagnosis or determination of acute compartment syndrome) at step 330.

[0092] In some instances, the implantable device may be configured to compare the pressure readings taken of the surrounding tissue to a threshold pressure value. When the surrounding tissue pressure is superior to the threshold value, a command is generated by the controller of the implantable device to cause the energy emitter to generate energy for performing cell electroporation.

[0093] In some instances, the implantable device may be configured to compare a change in pressure readings taken of the surrounding tissue to a threshold value of a change in pressure. When the detected change in pressure of the surrounding tissue is superior to the threshold value, a command is generated by the controller of the implantable device to cause the energy emitter to generate energy for performing cell electroporation.

[0094] In some embodiments, the pressure readings are communicated (wirelessly) to an external computer (e.g. computer 150). The external computer may include program code that, when executed by the processor, causes the processor to analyze the pressure readings to determine a presence of acute compartment syndrome. The external computer then transmits a command to the implantable device to cause the performance of cell electroporation. In some embodiments, the pressure readings communicated to the external computer are displayed (e.g. on a display of the external computer) to an operator (e.g. a doctor) who interprets the readings to determine if acutecompartment syndrome is present in the subject. If acute compartment syndrome is determined by the operator to be present, the operator may provide input on a user input device of the external computer for causing cell electroporation for treating the acute compartment syndrome.

[0095] In some instances, instead, following a determination from the pressure readings of the presence of acute compartment syndrome, the implantable device may be implanted into the target tissue of the subject for performing cell electroporation of the target tissue. In these examples, a separate implantable pressure monitor may be provided for generating pressure readings of the pressure of tissue of the subject following an implanting of the pressure monitor into tissue of the subject (an exemplary pressure monitor is described in U.S. Patent No. 11,633,212).

[0096] Although the invention has been described with reference to preferred embodiments, it is to be understood that modifications may be resorted to as will be apparent to those skilled in the art. Such modifications and variations are to be considered within the purview and scope of the present invention.

[0097] Representative, non-limiting examples of the present invention were described above in detail with reference to the attached drawing. This detailed description is merely intended to teach a person of skill in the art further details for practicing preferred aspects of the present teachings and is not intended to limit the scope of the invention. Furthermore, each of the additional features and teachings disclosed above and below may be utilized separately or in conjunction with other features and teachings.

[0098] Moreover, combinations of features and steps disclosed in the above detailed description, as well as in the experimental examples, may not be necessary to practice the invention in the broadest sense, and are instead taught merely to particularly describe representative examples of the invention. Furthermore, various features of the above-described representative examples, as well as the various independent and dependent claims below, may be combined in ways that are not specifically and explicitly enumerated in order to provide additional useful embodiments of the present teachings.

Claims

WHAT IS CLAIMED IS:

1. An implantable device for performing cell electroporation of a subject for treating acute compartment syndrome of the subject, comprising: a power source; an energy emitter configured to receive power from the power source and to emit energy for performing the cell electroporation; a controller configured to: receive input for causing cell electroporation; and generate a command for causing the energy emitter to emit the energy for performing the cell electroporation; and a housing for containing at least the controller.

2. The implantable device as defined in claim 1, further comprising a puncture device for implanting the implantable device into the subject.

3. The implantable device as defined in claim 1 or claim 2, further comprising a pressure monitor, wherein the controller is further configured to: receive pressure readings from the pressure monitor; and one of: cause a transmission of the pressure readings to an external computer, wherein a command received from the external computer to cause cell electroporation is the received input; and determine a presence of acute compartment syndrome from the pressure readings, wherein the pressure readings is the received input.

4. The device according to claim 3, wherein the energy emitter is operatively connected tothe pressure monitor and a device configured to provide a diastolic pressure and is configured to i) provide an alert or ii) causing a turning on of the device configured to provide a diastolic pressure if a delta pressure is equal or less than a second threshold value.

5. The device according to claim 3 or claim 4, wherein the controller is further configured to: receive a compartment pressure from the pressure monitor and compare the received compartment pressure with a threshold value; and cause the energy emitter to perform cell electroporation if the compartment pressure is greater than the threshold value.

6. The device according to any one of claims 1 to 5, further comprising a fluid drainage pump that is configured to remove fluid from a muscular compartment that is suffering from acute compartment syndrome.

7. The device according to any one of claims 1 to 6, wherein a size of the device is adapted for inserted into a muscular compartment via a single incision.

8. The device according to any one of claims 1 to 7, wherein the device is configured to be repeatedly sterilizable.

9. The device according to any one of claims 1 to 8, wherein the energy emitter is configured to perform pulse field ablation.

10. The device according to any one of claims 1 to 8, wherein the energy emitter is configured to perform cell electroporation using a pulsed electro-magnetic field.

11. The device according to any one of claims 1 to 9, further comprising an input / output interface for transmitting over a wireless connection pressure readings or an alert of a pressure of acute compartment syndrome to an external computer.

12. The device as defined in claim 11, wherein the wireless connection is a Bluetooth™ connection.

13. A kit comprising:the implantable device as defined in claim 1; and an implantable pressure monitor for generating pressure readings of tissue of a subject surrounding the pressure monitor once implanted into the subject.

14. A method for treatment, comprising: providing i) an implantable continuous compartment pressure monitor and ii) an implantable energy emitter; implanting and operating the continuous compartment pressure monitor to monitor a compartment pressure; and implanting the energy emitter and operating the energy emitter in order to cause cell electroporation.

15. Use of an energy emitter implantable into a muscular compartment for treating acute compartment syndrome by performing cell electroporation.

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