Oral pouch filler and oral pouch containing same

Abstract

The present invention relates to an oral pouch filler containing an active substance, the oral pouch filler comprising: an excipient comprising cellulose and sugar alcohols; a binder; a pH adjuster; and a flavoring agent, wherein the sugar alcohols include sorbitol, and when the oral pouch filler is used, the release rate of the active substance is controlled such that the absorption rate of the active substance into the body of a user can be controlled.

Description

Filler for oral pouch and oral pouch containing same

[0001] The present invention relates to a filler for an oral pouch and an oral pouch containing the same.

[0002] Oral pouches are intended for use in the oral cavity of users to allow the absorption of active substances such as nicotine. Pouch-type oral products, such as snus, are manufactured and packaged in an appropriate form using pouch packaging materials, containing granules containing active substances such as nicotine. Consumers place the pouch-type product between the gums and upper lip in the mouth, and can experience a sense of satisfaction as the active substances are absorbed over a period of time. The dissolution characteristics of these active substances are the most crucial characteristics of oral products, and while they can be controlled by the characteristics of the pouch material, they can also be affected by factors such as the composition of the filler and the manufacturing method.

[0003] Therefore, research is required to develop more effective release characteristics of active substances, including nicotine, from oral pouch fillers.

[0004] The present invention provides a filler for an oral pouch having improved dissolution characteristics of an active substance such as nicotine, and aims to provide a filler for an oral pouch having a specific type and addition ratio of sugar alcohols capable of delaying the release of an active substance, limited to sugar alcohols among the bulking agent components included in the filler.

[0005]

[0006] However, the problems to be solved by the present invention are not limited to those mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

[0007] According to one embodiment of the present invention, in a filler for an oral pouch comprising an active substance,

[0008] Excipients including cellulose and sugar alcohol;

[0009] bookbinder;

[0010] pH adjuster; and

[0011] Contains flavorings,

[0012] The present invention provides a filler for an oral pouch, characterized in that the sugar alcohol comprises sorbitol.

[0013]

[0014] According to one embodiment of the present invention, an oral pouch is provided, comprising a filler for the oral pouch and a packaging material surrounding the filler.

[0015] By using a filler for an oral pouch according to one embodiment of the present invention, the release rate of an active substance such as nicotine can be appropriately controlled (specifically, nicotine release delay) to control the rate of absorption of the active substance into the user's body, thereby providing the user with a sense of satisfaction when smoking.

[0016]

[0017] The effects of the present invention are not limited to the effects described above, and should be understood to include all effects that can be inferred from the detailed description of the present invention or the composition of the invention described in the claims.

[0018] Figure 1 is a drawing showing a graph of cumulative nicotine release over time for each oral pouch according to one embodiment of the present invention.

[0019] Figure 2 is a drawing showing a graph of nicotine release over time for each oral pouch according to one embodiment of the present invention.

[0020] Figure 3 is a drawing showing the dissolution rate according to the microcrystalline cellulose content of an oral pouch according to one embodiment of the present invention.

[0021] Below, embodiments are described in detail with reference to the attached drawings. However, the embodiments may be modified in various ways, and the scope of the patent application is not limited or restricted by these embodiments. It should be understood that all modifications, equivalents, or alternatives to the embodiments are included within the scope of the patent application.

[0022] The terms used in the examples are for illustrative purposes only and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as "comprise" or "have" are intended to indicate the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but should be understood to not preclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0023] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by a person of ordinary skill in the art to which the embodiments pertain. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with their meaning in the context of the relevant technology, and shall not be interpreted in an idealized or overly formal sense unless explicitly defined herein.

[0024] In addition, when describing with reference to the attached drawings, identical components will be assigned the same reference numerals regardless of the drawing numbers, and redundant descriptions thereof will be omitted. When describing embodiments, if a detailed description of a related known technology is judged to unnecessarily obscure the gist of the embodiment, the detailed description will be omitted.

[0025] Additionally, in describing components of an embodiment, terms such as first, second, A, B, (a), (b), etc. may be used. These terms are only intended to distinguish the components from other components, and the nature, order, or sequence of the components are not limited by the terms.

[0026] Components included in one embodiment and components with common functions will be described using the same names in other embodiments. Unless otherwise stated, the descriptions given in one embodiment can be applied to other embodiments, and detailed descriptions will be omitted to the extent of overlap.

[0027] Throughout the specification, when a part is said to "include" a component, this does not mean that it excludes other components, but rather that it may include other components.

[0028]

[0029] According to one embodiment of the present invention, in a filler for an oral pouch comprising an active substance,

[0030] Excipients including cellulose and sugar alcohol;

[0031] bookbinder;

[0032] pH adjuster; and

[0033] Contains flavorings,

[0034] The above sugar alcohol can provide a filler for an oral pouch, characterized in that it includes sorbitol.

[0035] The filler for an oral pouch according to one embodiment of the present invention can realize desirable dissolution characteristics of an active substance present in the pouch by including the above-described composition.

[0036] Effective dissolution characteristics of pouch-type products mean that from the consumer's perspective, rapid recognition or satisfaction due to the dissolution of the active substance during use is required, and at the same time, all applied active substances must be dissolved within a certain period of time. For example, in the case of a mini-sized pouch-type product, the size is 30 mm × 12 mm, and the active substance should be dissolved within approximately 20 minutes of use, at a level of 0.3 to 0.5 g.

[0037]

[0038] A filler for an oral pouch according to one embodiment of the present invention may include, together with an active substance, an excipient, a binder, a pH regulator, and a flavoring agent.

[0039] The above active substance is a substance that can be absorbed through the oral mucosa or gums, and specifically, may include nicotine, vitamins, caffeine, amino acids, salts or derivatives thereof, and preferably, may include nicotine or a nicotine salt. The nicotine may be synthetic nicotine and / or a nicotine extract from a tobacco plant, and the nicotine salt may include, but is not limited to, nicotine salt benzoate, nicotine salt tartrate, nicotine salt malate, nicotine salt salicylate, and the like.

[0040] In particular, when applying a nicotine derivative or the like as an active material, a pH regulator can be applied to provide an alkaline environment during use of the product to generate free nicotine, and the pH of the filler for oral pouches can be specifically adjusted to 7 to 9 through the pH regulator. Specific examples of the pH regulator include metal hydroxides such as sodium hydroxide and potassium hydroxide, metal carbonates such as sodium carbonate and potassium carbonate, sodium bicarbonate, sodium sesquicarbonate (Na3H(CO3)2), and the like. In particular, the pH regulator is suitably added so that the pH of the filler is at the level of 8.3 to 8.5 for effective nicotine absorption, and accordingly, the pH regulator preferably includes sodium bicarbonate and sodium carbonate, and the ratio thereof is 7:3 to 6:4.

[0041] The excipients may include cellulose, sugar alcohols, non-tobacco plant materials, and the like. In one embodiment of the present invention, the excipients include cellulose and sugar alcohols. The cellulose may serve as a carrier for active substances such as nicotine, and further, as a diluent, it has a high water-holding capacity, promotes wetting of the powdered mixture through swelling and wicking, and may play a role in rapidly releasing saliva and nicotine. In addition, the cellulose may provide a feeling of use. If cellulose is not added, the filler for the oral pouch may melt out.

[0042] The above cellulose includes microcrystalline cellulose, cellulose, cellulose derivatives, etc., and specific examples thereof include microcrystalline cellulose (MCC), methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, etc.

[0043] More specifically, the cellulose includes microcrystalline cellulose, and the content of the microcrystalline cellulose may be 1 to 2 times the content of the active substance such as nicotine, and may include 5 to 20 wt% to 20 wt% of the filler solids. If the content of the cellulose is less than the numerical range described above, the carrier role of nicotine, etc. may not be properly performed, and the filler for the oral pouch may dissolve quickly. On the other hand, if the content of the cellulose exceeds the numerical range described above, the nicotine dissolution rate may be excessively delayed due to the water-insoluble nature of the cellulose.

[0044] Meanwhile, sugar alcohols dissolve readily in saliva and bind more loosely to solvents than cellulose, allowing them to control nicotine release within the dosage period, suppress bitterness, and provide a cooling effect upon dissolution in the mouth. Furthermore, sugar alcohols can promote nucleation and granule growth during the high-shear wet granulation process for filling materials for oral pouches.

[0045] The content of the sugar alcohol may be 50 to 70 wt%, preferably 60 to 70 wt%, based on the total solid contents of the filler for the oral pouch. If the content of the sugar alcohol is less than the numerical range described above, the nuclei of the filler particles for the oral pouch may not be sufficiently formed. On the other hand, if the content of the sugar alcohol exceeds the numerical range described above, severe clumping or crushing of the powder may occur, making it difficult to manufacture the filler for the oral pouch.

[0046] In one embodiment of the present invention, when the effect of delaying the release rate of nicotine is taken into consideration, it is preferable that the sugar alcohol includes sorbitol, and it is more preferable in terms of effectiveness that the sorbitol is included in an amount of 50 wt% or more based on the total sugar alcohol. In addition, the sugar alcohol may additionally include isomalt, erythritol, arabitol, ribitol, maltitol, dulcitol, iditol, mannitol, xylitol, lactitol, etc., in addition to the sorbitol. Furthermore, examples of the non-tobacco plant material are not particularly limited, and may include coconut shells, vegetable fibers, tea, herbs, coffee, fruits, etc.

[0047] The above binder may include at least one selected from the group consisting of hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), polyvinyl pyrrolidone (PVP), sodium alginate, xanthan gum, guar gum, gellan gum, and gum arabic, and the amount used may be 10 wt% or less, preferably 5 to 8 wt%, based on the filler.

[0048] The above flavoring agent is also referred to as a "flavoring agent" and refers to any aromatic substance capable of changing the sensory characteristics associated with an oral product. The flavoring agent may be a natural flavoring agent or a synthetic flavoring agent, and specific types may include, but are not limited to, vanilla, coffee, chocolate / cocoa, cream, mint, spearmint, menthol, peppermint, wintergreen, eucalyptus, lavender, cardamom, nutmeg, cinnamon, clove, cascarilla, sandalwood, honey, ginger, anise, sage, licorice, lemon, orange, apple, peach, lime, cherry, strawberry, etc.

[0049] In addition, the filler for oral pouches according to one embodiment of the present invention may additionally include a sweetener, a moisturizer, an antioxidant, a preservative, etc., depending on the intended use and need, in addition to the composition described above.

[0050] The above sweetener may be a natural sweetener or an artificial sweetener, and specific types thereof include, but are not limited to, fructose, sucrose, glucose, maltose, mannose, galactose, lactose, stevia, honey, sucralose, isomaltose, maltodextrin, saccharin, and aspartame.

[0051] The above moisturizer may include, for example, at least one of glycerin and propylene glycol.

[0052]

[0053] According to one embodiment of the present invention, an oral pouch can be provided, comprising a filler for an oral pouch as described in detail above and a packaging material surrounding the filler.

[0054] The above oral pouch packaging material is safe for the human body, can retain saliva well, has a certain strength to prevent tearing, and has sealing properties. The material of the oral pouch packaging material may be a nonwoven type or a woven type, preferably a nonwoven type. Unlike the woven type, the nonwoven type has fibers that are entangled, so there is no longitudinal or transverse direction, and the cut edges may not fray.

[0055] The packaging material for the above oral pouch may specifically include cellulose fibers and thermoplastic material fibers.

[0056] At this time, the cellulose fiber may include not only cellulose but also cellulose-based fibers, and the cellulose-based fibers may include at least one of natural cellulose-based fibers or artificial cellulose-based fibers.

[0057] In addition, the natural cellulose fiber may include at least one selected from the group consisting of seed hair fiber, bark fiber, leaf fiber, and wood fiber (pulp). For example, the seed hair fiber may include cotton, bombax cotton, kapok, etc. For example, the bark fiber may include hemp, flax, jute, ramie, paper mulberry, paper mulberry, etc. For example, the leaf fiber may include Manila hemp, New Zealand hemp, etc. For example, the wood fiber (pulp) may include at least one of softwood pulp and hardwood pulp depending on the type and characteristics of the tree, and for example, may include coniferous fiber, broadleaf fiber, etc.

[0058] The man-made cellulosic fiber may include at least one of regenerated cellulose fibers or semi-synthetic fibers. Examples of regenerated cellulose fibers include viscose, rayon, and polyurethane. Examples of semi-synthetic fibers include acetate rayon. Rayon may include not only rayon but also rayon-based fibers that complement the shortcomings of rayon. Examples of rayon-based fibers include Tencel, Lyocell, and Modal.

[0059] Meanwhile, the thermoplastic material fiber may include at least one selected from the group consisting of nylon, polyethylene, polylactic acid, polypropylene, polyethersulfone, and polyethylene terephthalate, and by including the thermoplastic material fiber, the packaging material for the oral pouch may be heat-sealable.

[0060]

[0061] Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.

[0062]

[0063] 1. Example 1: Experimental evaluation according to the type and content of sugar alcohol

[0064] (1) Manufacturing Example 1-1: Manufacturing of filler for oral pouch

[0065] Example 1-1: After mixing nicotine, excipients (microcrystalline cellulose, maltitol), binder, pH regulator, and flavoring in the first stage, a solvent (water alone, water + ethanol, or ethanol alone) was sprayed, and a granulation step was performed to manufacture an oral pouch filler. At this time, the contents of the microcrystalline cellulose (MCC) and maltitol were 25 wt% and 50 wt%, respectively, based on the total solid contents of the oral pouch filler.

[0066] Example 1-2: A filler was prepared in the same manner as in Example 1-1, except that the excipients were composed of 25 wt% MCC, 25 wt% maltitol, and 25 wt% sorbitol based on the solid content.

[0067] Example 1-3: A filler was prepared in the same manner as in Example 1-1, except that the excipients were composed of 25 wt% of microcrystalline cellulose (MCC) and 50 wt% of sorbitol relative to the solid content.

[0068]

[0069] (2) Experimental Example 1-1: Analysis of physical properties of oral pouches

[0070] For the pouches of Examples 1-1 to 1-3 manufactured in Manufacturing Example 1-1 above, the total nicotine content, pH, average particle size, and moisture content were analyzed, and the results are shown in Table 1 below.

[0071]

[0072]

[0073] (3) Experimental Example 1-2: Evaluation of nicotine release characteristics

[0074] For the oral pouches of Examples 1-1 to 1-3 manufactured in Manufacturing Example 1-1 above, the average amount of nicotine per time zone and the cumulative amount of nicotine were measured. The results are shown in Table 2 below.

[0075]

[0076]

[0077] (4) Experimental Example 1-3: Sensory Evaluation of Oral Pouches

[0078] For the oral pouches of Examples 1-1 to 1-3 manufactured in the above Manufacturing Example 1-1, a sensory evaluation was conducted on the company's panel by using the oral pouches for 30 minutes and then resting for 1 hour, and the results are shown in Table 3 below.

[0079]

[0080]

[0081] 2. Example 2: Nicotine release rate according to the content of microcrystalline cellulose

[0082] (1) Manufacturing Example 2-1: Manufacturing of oral pouch filler

[0083] Example 2-1: After mixing nicotine, microcrystalline cellulose, maltitol, a binder, a pH regulator, and a flavoring agent in the first stage, a solvent (water alone, water + ethanol, or ethanol alone) was sprayed, and a granulation step was performed to manufacture an oral pouch filler. At this time, the binder was hydroxypropyl cellulose, and the content of microcrystalline cellulose was 20 wt% based on the total solid contents of the oral pouch filler.

[0084] Example 2-2: It was manufactured in the same manner as Example 2-1, except that the content of microcrystalline cellulose was 25 wt%.

[0085] Comparative Example 2-1: It was manufactured in the same manner as Example 2-1, except that the content of microcrystalline cellulose was 40 wt%.

[0086] Comparative Example 2-2: It was manufactured in the same manner as Example 2-1, except that the content of microcrystalline cellulose was 55 wt%.

[0087]

[0088] (2) Experimental Example 2-1: Evaluation of nicotine release characteristics

[0089] The nicotine release rates of Examples 2-1 to 2-2 and Comparative Examples 2-1 to 2-2 were analyzed. The nicotine release rates were evaluated by measuring the content of released nicotine after leaving the Examples and Comparative Examples in 1 liter of phosphate buffer maintained at 37°C and pH 7.4 for 1 minute using a USP paddle apparatus. The results are shown in Fig. 3 and Table 4.

[0090]

[0091]

[0092] Example 2-1 showed that 90% of the added nicotine content was released after the initial 1 minute, and the dissolution rate after the initial 4 minutes was 17.5%, showing the highest dissolution rate. In addition, Example 2-2 showed the second highest dissolution rate after the initial 4 minutes, showing 16.1%. However, when the content of microcrystalline cellulose increased, the dissolution rate after the initial 4 minutes tended to decrease rapidly due to the water-insoluble nature of microcrystalline cellulose (Comparative Examples 2-1 to 2-2).

[0093]

[0094] 3. Example 3: Nicotine release rate according to the addition of sugar alcohol

[0095] (1) Manufacturing Example 3-1: Manufacturing of oral pouch filler

[0096] Example 3-1: Similar to Example 2-1, an oral pouch filler was prepared, wherein the content of maltitol was 70 wt% based on the total solid contents of the oral pouch filler, and the content of microcrystalline cellulose was 5 wt% based on the total solid contents.

[0097] Example 3-2: A method was used in the same manner as in Example 3-1, except that the content of maltitol was 55 wt% based on the total weight of solids, and accordingly, the content of microcrystalline cellulose was 20 wt% based on the total weight of solids.

[0098]

[0099] (2) Experimental Example 3-1: Evaluation of nicotine release characteristics

[0100] The nicotine release rates of Examples 3-1 and 3-2 were analyzed. The nicotine release rates were evaluated using the same method as the experimental examples described above.

[0101] As a result, Example 3-1 showed a nicotine release rate of 20% after the initial 4 minutes and 80% after 20 minutes, and Example 3-2 showed a nicotine release rate of 14% after the initial 4 minutes and 51.6% after 20 minutes. It is believed that this is because, as the content of microcrystalline cellulose increases, the release rate decreases after the initial 4 minutes and 20 minutes due to the water-insoluble nature of microcrystalline cellulose.

[0102]

[0103] 4. Example 4: Particle size distribution and nicotine release rate according to binder type

[0104] (1) Manufacturing Example 4-1: Manufacturing of oral pouch filler

[0105] Example 4-1: After mixing nicotine, microcrystalline cellulose, maltitol, binder, pH regulator, and flavoring in the first stage, a solvent of water alone, water + alcohol, or alcohol alone was sprayed, and a granulation step was performed to manufacture an oral pouch filler.

[0106] The above binder was hydroxypropyl cellulose, and the content of the binder was 8 wt% based on the total weight of the filler.

[0107] Example 4-2: It was manufactured in the same manner as Example 4-1, except that povidone K-25 was used as a binder.

[0108] Example 4-3: It was manufactured in the same manner as Example 4-1, except that low-substituted hydroxypropyl cellulose was used as a binder.

[0109]

[0110] (2) Experimental Example 4-1: Evaluation of nicotine release characteristics

[0111] The nicotine release rates of Examples 3-1 and 4-1 to 4-3 were analyzed. The nicotine release rates were evaluated using the same method as the experimental examples described above. The results are shown in Table 5 below.

[0112]

[0113]

[0114] In Examples 3-1 and 4-1, oral pouch filler particles having a size of 200 μm or more were distributed at a rate of 66.7% or more, and oral pouch filler particles having a size of 50 μm or less were not present. Examples 3-1 and 4-1 had higher nicotine release rates not only initially but also after 20 minutes compared to Examples 4-2 and 4-3.

[0115]

[0116] 5. Example 5: Free-base nicotine production rate according to pH range and pH regulator ratio

[0117] (1) Manufacturing Example 5-1: Manufacturing of oral pouch filler

[0118] Example 5-1: The oral pouch filler contained a pH regulator, and the pH regulator used sodium bicarbonate and sodium carbonate in a ratio of 6:4.

[0119] Example 5-2: It was manufactured in the same manner as Example 5-1, except that sodium bicarbonate and sodium carbonate were used in a ratio of 7:3 as a pH adjuster.

[0120] Comparative Example 5-1: It was manufactured in the same manner as Example 5-1, except that sodium bicarbonate and sodium carbonate were used as pH adjusters in a ratio of 8:2.

[0121]

[0122] (2) Experimental Example 5-1: Evaluation of nicotine release characteristics

[0123] The pH and free-base nicotine production ratio of the oral pouch fillers of Examples 5-1, 5-2, and Comparative Example 5-1 were investigated, and the results are shown in Table 6.

[0124]

[0125]

[0126] Unlike Comparative Example 5-1, Examples 5-1 and 5-2 showed results in which the pH of the saliva was 8.8 and 8.4, respectively, and the free-base nicotine production rate was 76% or more. This confirms that when saliva with a pH of 6.5 to 7.7 is introduced, the pH becomes 8.02 or higher, and thus more free-base nicotine is produced.

[0127]

[0128] Although the embodiments described above have been described with limited drawings, those skilled in the art will appreciate that various technical modifications and variations can be applied based on the above. For example, appropriate results can still be achieved even if the described techniques are performed in a different order than described, and / or components of the described systems, structures, devices, circuits, etc. are combined or combined in a different manner than described, or are replaced or substituted with other components or equivalents.

[0129]

[0130] Therefore, other implementations, other embodiments, and equivalents to the claims also fall within the scope of the claims described below.

Claims

1. In a filler for oral pouch containing an active substance, Excipients including cellulose and sugar alcohol; bookbinder; pH adjuster; and Contains flavorings, A filler for an oral pouch, characterized in that the sugar alcohol comprises sorbitol.

2. In paragraph 1, A filler for an oral pouch, wherein the above sorbitol is contained in an amount of 50 wt% or more based on the total sugar alcohol.

3. In paragraph 1, A filler for an oral pouch, wherein the active substance comprises at least one selected from the group consisting of nicotine, vitamins, caffeine, salts thereof, and derivatives thereof.

4. In paragraph 1, The cellulose comprises at least one selected from the group consisting of microcrystalline cellulose (MCC), methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, and carboxymethylcellulose, A filler for an oral pouch, wherein the sugar alcohol comprises, in addition to sorbitol, at least one selected from the group consisting of isomalt, erythritol, arabitol, ribitol, maltitol, dulcitol, iditol, mannitol, xylitol, and lactitol.

5. In paragraph 1, The above cellulose includes microcrystalline cellulose, A filler for an oral pouch, wherein the content of the microcrystalline cellulose is 1 to 2 times the content of nicotine and is 5 to 20 wt% based on the weight of the total solid contents of the oral pouch filler.

6. In paragraph 1, A filler for an oral pouch, wherein the binder comprises at least one selected from the group consisting of hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), polyvinyl pyrrolidone (PVP), sodium alginate, xanthan gum, guar gum, gellan gum, and gum arabic.

7. In paragraph 1, The above binder comprises hydroxypropyl cellulose (HPC), A filler for an oral pouch, wherein the content of the above hydroxypropyl cellulose (HPC) is 5 to 8 wt% based on the filler.

8. In paragraph 1, A filler for an oral pouch, wherein the pH adjusting agent comprises at least one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, and sodium sesquicarbonate (Na3H(CO3)2).

9. In paragraph 8, The above pH regulator includes sodium bicarbonate and sodium carbonate, The above sodium bicarbonate and sodium carbonate are included in a weight ratio of 7:3 to 6:4, A filler for oral pouches, wherein the pH of the filler is 8.3 to 8.

5.

10. In paragraph 1, A filler for an oral pouch, wherein the flavoring agent comprises at least one selected from the group consisting of vanilla, coffee, chocolate / cocoa, cream, mint, spearmint, menthol, peppermint, wintergreen, eucalyptus, lavender, cardamom, nutmeg, cinnamon, clove, cascarilla, sandalwood, honey, ginger, anise, sage, licorice, lemon, orange, apple, peach, lime, cherry and strawberry.

11. In paragraph 1, A filler for an oral pouch, wherein the filler further comprises at least one of a sweetener, a moisturizer, an antioxidant, and a preservative.

12. An oral pouch comprising a filler for an oral pouch as described in paragraph 1 and a packaging material surrounding the filler.

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