Nicotine pouch and packaging method therefor

Abstract

The present invention relates to a nicotine pouch comprising a nicotine pouch filler and a packaging material, wherein the volume filling rate of the nicotine pouch filler is 60% to 75% on the basis of the internal volume of the nicotine pouch.

Description

Nicotine pouch and packaging method thereof

[0001] The present invention relates to a nicotine pouch and a packaging method thereof.

[0002] Nicotine pouches are a type of smoking device used in the mouth to provide nicotine gratification. For example, nicotine pouches can be used by placing the pouch between the upper or lower gums and the lips and holding it there for a limited period of time.

[0003] Nicotine pouches consist of a filler encapsulated in a pouch material. The pouch material holds the filler in place, allowing saliva to pass through the filler, and the flavor and nicotine released from the filler diffuse into the user's mouth.

[0004] Therefore, there is a need for a nicotine pouch that can release most or all of the nicotine from the nicotine pouch filler in an appropriate amount and is not uncomfortable to use orally.

[0005] The purpose of the present invention is to provide a nicotine pouch having excellent nicotine release rate and usability.

[0006]

[0007] However, the problems to be solved by the present invention are not limited to those mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

[0008] According to one embodiment of the present invention, a nicotine pouch filler and packaging material are included,

[0009] A nicotine pouch is provided, wherein the volume filling ratio of the nicotine pouch filler is 60% to 75% of the internal volume of the nicotine pouch.

[0010]

[0011] According to one embodiment of the present invention, there is provided a method of manufacturing a nicotine pouch filler, comprising the steps of: wrapping a nicotine pouch filler with a packaging material; and

[0012] A step of sealing the above packaging material; including;

[0013] A nicotine pouch packaging method is provided, wherein the volume filling ratio of the nicotine pouch filler is 60% to 75% of the internal volume of the nicotine pouch.

[0014] By using the nicotine pouch and packaging method of the present invention, nicotine can be effectively extracted from the nicotine pouch filler and a comfortable feeling of use can be provided.

[0015]

[0016] The effects of the present invention are not limited to the effects described above, and should be understood to include all effects that can be inferred from the detailed description of the present invention or the composition of the invention described in the claims.

[0017] FIG. 1 is a side view of a nicotine pouch according to one embodiment of the present invention.

[0018] Figure 2 is a diagram showing the results of the nicotine release rate of a nicotine pouch according to one embodiment of the present invention.

[0019] Below, embodiments are described in detail with reference to the attached drawings. However, the embodiments may be modified in various ways, and the scope of the patent application is not limited or restricted by these embodiments. It should be understood that all modifications, equivalents, or alternatives to the embodiments are included within the scope of the patent application.

[0020] The terms used in the examples are for illustrative purposes only and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as "comprise" or "have" are intended to indicate the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but should be understood to not preclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0021] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by a person of ordinary skill in the art to which the embodiments pertain. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with their meaning in the context of the relevant technology, and shall not be interpreted in an idealized or overly formal sense unless explicitly defined herein.

[0022] In addition, when describing with reference to the attached drawings, identical components will be assigned the same reference numerals regardless of the drawing numbers, and redundant descriptions thereof will be omitted. When describing embodiments, if a detailed description of a related known technology is judged to unnecessarily obscure the gist of the embodiment, the detailed description will be omitted.

[0023] Additionally, in describing components of an embodiment, terms such as first, second, A, B, (a), (b), etc. may be used. These terms are only intended to distinguish the components from other components, and the nature, order, or sequence of the components are not limited by the terms.

[0024] Components included in one embodiment and components with common functions will be described using the same names in other embodiments. Unless otherwise stated, the descriptions given in one embodiment can be applied to other embodiments, and detailed descriptions will be omitted to the extent of overlap.

[0025] Throughout the specification, when a part is said to "include" a component, this does not mean that it excludes other components, but rather that it may include other components.

[0026]

[0027] According to one embodiment of the present invention, a nicotine pouch can be provided, which includes a nicotine pouch filler and a packaging material, and wherein a volume filling ratio of the nicotine pouch filler is 60% to 75% of the internal volume of the nicotine pouch.

[0028] The nicotine pouch filler may be packaged within the packaging material, and the nicotine pouch filler may be filled in an appropriate amount to improve the performance and usability of the nicotine pouch. Preferably, the volumetric filling ratio of the nicotine pouch filler may be 65% to 70% of the internal volume of the nicotine pouch.

[0029] If the volumetric filling ratio of the nicotine pouch filler is below the numerical range described above, nicotine may not be sufficiently supplied, failing to satisfy the satisfaction of smoking, and may easily slip when used in the mouth. On the other hand, if the volumetric filling ratio of the nicotine pouch filler exceeds the numerical range described above, the pouch may contain too much nicotine pouch filler, which may hinder nicotine dissolution, and the hardness may cause a foreign body sensation when used.

[0030]

[0031] In one embodiment of the present invention, the nicotine pouch may have a thickness of 2.8 mm to 4.5 mm, preferably 3 mm to 3.5 mm. If the thickness of the nicotine pouch is less than the above-described numerical range, it is difficult to be fixed between the upper gum and the oral cavity, and due to excessive flexibility, it may easily move, such as slipping, during conversation or drinking, and the user may feel a foreign body sensation. On the other hand, if the thickness of the nicotine pouch filler exceeds the above-described numerical range, the nicotine pouch may be excessively hard when used in the oral cavity, and a foreign body sensation may be felt when used.

[0032]

[0033] The internal volume of a nicotine pouch may vary depending on the size of the nicotine pouch.

[0034] Nicotine pouches can be categorized by size and weight into original, slim, super slim, and mini. The original is the most common size for snus products and is primarily used in North America. The slim is the most common size for nicotine pouches and is primarily used in Europe. The super slim is smaller than the slim and is aimed at female consumers. The mini is a smaller nicotine pouch and is primarily used in Europe.

[0035] In a nicotine pouch according to one embodiment of the present invention, the size of the nicotine pouch may have a vertical length of 11 mm to 17 mm and a horizontal length of 25 mm to 32 mm. For example, the nicotine pouch may have a vertical length of 12 mm to 14 mm and a horizontal length of 28 mm to 30 mm.

[0036] In a nicotine pouch according to one embodiment of the present invention, the weight of the nicotine pouch may be 0.3 g to 0.6 g. The weight of the nicotine pouch may be the result of adding the weights of the nicotine pouch filler and the packaging material.

[0037] The size and weight of the nicotine pouch must meet the above-described ranges, so that a nicotine pouch having a short length, a thin thickness, and a usage time of 20 to 40 minutes can be provided.

[0038]

[0039] In a nicotine pouch according to one embodiment of the present invention, the internal volume of the nicotine pouch is 0.8 cm 3 1.2 cm in diameter 3 It can be. For example, the internal volume of the nicotine pouch is 1 cm 3 1.1 cm in diameter 3 It could be.

[0040]

[0041] The packaging material may be packaged in a three-sided packaging or a double-sided packaging manner, and the sealing of the packaging material may be accomplished by ultrasonic sealing or heat sealing. The packaging material has a longitudinal seal formed along the width of the packaging material and a cross seal formed along the length of the packaging material, and the cross seal and / or the longitudinal seal may be sealed by a lap seal or a fin seal.

[0042] In a nicotine pouch according to one embodiment of the present invention, the packaging material is packaged using a wrap seal method, and the packaging material may be sealed with a width of 1 mm to 3 mm. The wrap seal method is a packaging method that can be used in a packaging machine, and may be an advantageous method for improving leakage prevention against a circular support member surrounding an opening in a circular type packaging method. If the sealing width is excessively wide beyond the above-described range, the user may feel a foreign body sensation due to the sealing member and a sharpness of the cut surface.

[0043]

[0044] In a nicotine pouch according to one embodiment of the present invention, the nicotine pouch filler may include: nicotine; a release-controlling excipient including at least one selected from the group consisting of cellulose and sugar alcohol; a binder; a pH regulator; and a flavoring agent.

[0045] In the above nicotine pouch filler, nicotine may include a nicotine salt, and the type of nicotine salt may include, for example, at least one selected from the group consisting of nicotine salt benzoate, nicotine salt tartrate, nicotine salt malate, and nicotine salt salicylate.

[0046] The nicotine content can be determined based on the intended strength of the nicotine pouch. If the nicotine content falls below the range described above, it may be difficult to provide smokers with a satisfying smoking experience. Conversely, if the nicotine content exceeds the range described above, the nicotine stimulation may be excessive.

[0047] In the above nicotine pouch filler, the release-controlling excipient can play a role in controlling the nicotine release rate.

[0048] Among the above-mentioned controlled-release excipients, cellulose can act as a carrier for nicotine, rapidly release saliva and nicotine, and provide a pleasant sensation of use. The cellulose may be at least one of microcrystalline cellulose (MCC) and methyl cellulose.

[0049] The content of the cellulose may be 1 to 2 times the content of the nicotine. The content of the cellulose may be 5 to 20 wt% based on the weight of the total solid contents of the nicotine pouch filler. If the content of the cellulose is less than the numerical range described above, the nicotine pouch filler may melt quickly. On the other hand, if the content of the cellulose exceeds the numerical range described above, the nicotine release rate may be delayed due to the water-insoluble nature of the cellulose.

[0050] Among controlled-release excipients, sugar alcohols are highly soluble in saliva and bind more loosely to solvents than cellulose. Therefore, they can control the release of nicotine within the dosage period, suppress bitterness, and provide a cooling effect upon dissolution in the mouth. Furthermore, sugar alcohols can promote nucleation and granule growth during the high-shear wet granulation process for nicotine pouch fillers.

[0051] The above sugar alcohol may include at least one selected from the group consisting of erythritol, xylitol, mannitol, sorbitol, maltitol, and isomalt, but is not limited to the examples described.

[0052] The content of the sugar alcohol may be 50 to 70 wt%, preferably 60 to 70 wt%, based on the total solid contents of the nicotine pouch filler. If the content of the sugar alcohol is less than the numerical range described above, the nuclei of the nicotine pouch filler particles may not be sufficiently formed. On the other hand, if the content of the sugar alcohol exceeds the numerical range described above, severe clumping or crushing of the powder may occur, making it difficult to manufacture the nicotine pouch filler.

[0053]

[0054] The type and content of the binder can affect the size distribution formation of the nicotine pouch filler particles.

[0055] In the above nicotine pouch filler, the binder may include, for example, at least one selected from the group consisting of povidone K-25, hydroxypropylcellulose (HPC), low substituted hydroxypropylcellulose (L-HPC), hydroxypropylmethylcellulose (HPMC), and carboxymethylcellulose (CMC).

[0056] The content of the above binder may be 10 wt% or less, preferably 8 to 15 wt%, based on the total solid contents of the nicotine pouch filler. If the type and content of the binder exceed the above-described range, it may be difficult to secure the required particle size and may adversely affect the initial dissolution.

[0057] The binder can be added by wet binder addition or dry binder addition.

[0058] The pH adjuster can adjust the pH of the nicotine pouch filler to a pH at which nicotine can be absorbed, so that when the nicotine pouch is inserted into the oral cavity, the nicotine can be converted into a rapidly absorbable free-based nicotine form.

[0059] The pH of the nicotine pouch filler may be 8.3 to 8.5. When the pH is 8.02 or higher, nicotine is converted to a free-base nicotine form, which can be rapidly absorbed through the mucosa. Therefore, when the pH of the nicotine pouch filler satisfies the above-described numerical range, when mixed with saliva (pH 6.5 to 7.7), the pH becomes 8.02 or higher, allowing nicotine to be easily absorbed and having a strong impact on the consumer.

[0060] The pH adjuster may be, for example, at least one selected from the group consisting of sodium bicarbonate and sodium carbonate. The weight ratio of the sodium bicarbonate and sodium carbonate may be 7:3 to 6:4, preferably 6:4. If sodium bicarbonate is added in a greater proportion (a relatively smaller proportion of sodium carbonate) than the ratio described above, the pH may be lowered, resulting in insufficient absorption of nicotine. On the other hand, if sodium bicarbonate is added in a lesser proportion (a relatively larger proportion of sodium carbonate) than the ratio described above, the pH may be higher than the desired range, resulting in insufficient oral dissolution.

[0061]

[0062] The flavoring may be anything that provides a taste to satisfy the smoker's preference, and is not limited to a specific flavoring. For example, the flavoring may include at least one selected from the group consisting of menthol, licorice, sucrose, fructose syrup, iso-sweetener, cocoa, lavender, cinnamon, cardamom, celery, fenugreek, cascarilla, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, mint oil, caraway, cognac, jasmine, chamomile, cinnamon, ylang-ylang, sage, spearmint, peppermint, ginger, coriander, and coffee.

[0063]

[0064] In a nicotine pouch according to one embodiment of the present invention, the nicotine pouch filler may comprise 65% to 75% of particles having a size of 200 μm or more, and 0% to 35% of particles having a size of 100 μm or more and less than 200 μm. Preferably, the nicotine pouch filler may comprise 65% to 70% of particles having a size of 200 μm or more, and 20% to 30% of particles having a size of 100 μm or more and less than 200 μm. The remainder may be particles having a size of 100 μm or less. The nicotine pouch filler may not comprise fine particles having a size of 50 μm or less.

[0065] When the size of the nicotine pouch filler satisfies the numerical range described above, nicotine can be efficiently released. If the nicotine pouch filler contains too many small particles, there may be a problem with nicotine not being released initially. Conversely, if the nicotine pouch filler contains too many large particles, all of the nicotine may be released initially, resulting in nicotine not being available to the user later in use.

[0066]

[0067] In a nicotine pouch according to one embodiment of the present invention, the density of the nicotine pouch filler is 0.34 g / cm 3 0.74 g / cm 3 , preferably 0.4 g / cm 3 0.6 g / cm 3 , more preferably 0.53 g / cm 3 0.55 g / cm 3 It could be.

[0068]

[0069] In a nicotine pouch according to one embodiment of the present invention, the content of the nicotine pouch filler may be 280 mg to 460 mg, preferably 300 mg to 400 mg.

[0070] In a nicotine pouch according to one embodiment of the present invention, the filling density of the nicotine pouch filler may be 0.26 g / cc to 0.44 g / cc, preferably 0.28 g / cc to 0.39 g / cc. The filling density may be expressed as the content of the nicotine pouch filler / the internal volume of the nicotine pouch.

[0071] If the content and filling density of the nicotine pouch filler are below the numerical ranges described above, the nicotine pouch use time may be reduced, the initial nicotine release amount may increase due to dissolution imbalance, and the durability may be reduced. On the other hand, if the content and filling density of the nicotine pouch filler exceed the numerical ranges described above, the nicotine dissolution may be hindered due to the inclusion of too much nicotine pouch filler.

[0072]

[0073] In a nicotine pouch according to one embodiment of the present invention, the nicotine pouch filler may be provided by the following manufacturing method. The manufacturing method of the nicotine pouch filler includes a step (S1) of mixing at least one selected from the group consisting of nicotine, a release-controlling excipient, a binder, a pH regulator, and a flavoring; a step (S2) of spraying a solvent; and a step (S3) of granulating; wherein, in the step S1, the release-controlling excipient includes at least one selected from the group consisting of cellulose and sugar alcohol, and in the step S2, the solvent is at least one selected from the group consisting of water, ethanol, and alcohol, and in the step S2, the content of the solvent may be 10 to 60 wt% of the content of the cellulose, and in the step S2, the L / S ratio may be 8 to 15%.

[0074] Below, each step is explained in detail.

[0075] Step S1 is a step of mixing at least one selected from the group consisting of nicotine, a release-controlling excipient, a binder, a pH regulator, and a flavoring agent. At this time, the components are prepared in powder form and can be uniformly mixed.

[0076] The above nicotine may include a nicotine salt, and the type of the nicotine salt is the same as the example described above.

[0077] The above-mentioned release-controlling excipient may include at least one selected from the group consisting of cellulose and sugar alcohols. Among the release-controlling excipients, the sugar alcohol may promote nucleus formation and granule growth during the granulation step.

[0078] The type of binder is the same as the previously described example. The method of adding the binder can particularly affect the granulation process. The binder can be added via a wet binder addition method or a dry binder addition method, preferably a dry binder addition method. When added via a dry binder method, it facilitates the formation of particles of the desired size, ensures a uniform particle size distribution, and facilitates manufacturing.

[0079] The types of the pH regulator and fragrance are the same as those in the examples described above.

[0080] Step S2 is a step of spraying a solvent. At this time, the solvent can be sprayed and mixed into the powder mixture prepared in step S1.

[0081] At this time, the solvent may be at least one of water or alcohol, and preferably alcohol.

[0082] The content of the solvent may be 10 to 60 wt%, preferably 40 to 50 wt%, of the content of the cellulose. The amount of the solvent added may also be expressed by the L / S ratio. The L / S ratio is expressed as the total weight of the solvent / total weight of the solid powder mixture, and the total weight of the solid powder mixture may be the total weight of at least one selected from the group consisting of nicotine, a release-controlling excipient, a binder, a pH regulator, and a flavoring added in step S1. The L / S ratio may be 8 to 15%, preferably 10 to 12%. When the L / S ratio satisfies the numerical range described above, fine particles having a uniform size and a size of less than 100 μm are generated in small amounts or not at all, and particles having a porous structure can be formed, which may be advantageous for nicotine release. When the L / S ratio is less than the numerical range described above, nicotine may not be well eluted. On the other hand, if the L / S ratio exceeds the numerical range described above, particles of irregular shape are formed, the particle size range becomes small, and nicotine may be released too quickly.

[0083] Step S3 is the granulation step. At this time, the powder mixture and solvent prepared in step S2 are stirred for 5 to 30 minutes, and the clumps of particles formed during the stirring process can be broken up and separated into individual particles.

[0084]

[0085] According to one embodiment of the present invention, the packaging material may include: cellulose fibers; and thermoplastic material fibers.

[0086] The packaging material may be safe for the human body, able to retain saliva well, have a certain strength to prevent tearing, and have sealing properties.

[0087] Cellulose fibers can increase the airtightness and physical strength of packaging materials for nicotine pouches, and can also improve the usability (softness).

[0088] For example, the cellulose fiber may include at least one selected from the group consisting of cellulose, viscose, rayon, and pulp.

[0089] If the cellulose fibers are pulp, the pulp may be refined. "Refining" may refer to the process of mechanically cutting the fibers in water to finely sculpt them. Refining the pulp alters the length and structure of the fibers, making them more susceptible to hydrogen bonding, thereby imparting physical strength to the pouch material.

[0090] Meanwhile, by including thermoplastic material fibers, the packaging material for nicotine pouches can be heat-sealed.

[0091] For example, the thermoplastic material fiber may include at least one selected from the group consisting of nylon, polylactic acid, polyethylene, polypropylene, polyethylene / polypropylene, polyethersulfone, polyethylene terephthalate, and low-melting point polyethylene terephthalate (LMPET).

[0092] In addition, in the packaging material for a nicotine pouch according to one embodiment of the present invention, the thermoplastic material fiber is a dual-component fiber comprising two selected from the group consisting of polypropylene, polyethylene, polyethylene terephthalate, and polylactic acid, and the thermoplastic material fiber may form a core-shell structure. Such a core-shell structured fiber has the advantage of excellent physical properties and excellent sealing properties at low temperatures.

[0093] The thermoplastic material fiber may include staple fibers. Staple fibers are fibers having a discontinuous length, which may be cut from continuous filaments.

[0094] The material of the above packaging material is not limited to the ingredients described, and may further include a binder, etc.

[0095] The packaging material may be of a nonwoven type or a woven type.

[0096] A method for manufacturing a packaging material may include a process for forming a web and a process for bonding the web.

[0097] The process for forming the above web may be a dry-laid method, a wet-laid method, or a spinning method, and the dry method may be a carding method or an air-ray method. The wet method may be a general paper manufacturing method or a manufacturing method modified therefrom. The spinning method may be a spun-bonded method or a melt-blown method.

[0098] Meanwhile, the process for bonding the webs may include a mechanical bonding method, a chemical bonding method, or a thermal bonding method. The mechanical bonding method may be a needle-punching method or a spun-lacing method. The chemical bonding method may be a polymer dispersion method or a polymer solution method. The thermal bonding method may be a calendering method, a hot air method, or an ultrasonic method.

[0099] Preferably, the packaging material can be manufactured by a spun-lacing method and / or a wet method. The spun-lacing method may include a step of forming a web in the form of a sheet having a certain thickness from a clumped fiber raw material; a step of spraying moisture to entangle the fibers to form a packaging material; and a drying step. The wet method may include a step of dispersing a fiber raw material in water to produce a dispersion; a step of moving the dispersion to a press to form a packaging material; and a dehydration and drying step. However, the spun-lacing method and the wet method are not limited to including only the steps described above.

[0100] The packaging material may be porous to release the nicotine pouch filler contained therein.

[0101]

[0102] According to one embodiment of the present invention, a nicotine pouch packaging method can be provided, including the steps of wrapping a nicotine pouch filler with a packaging material; and the step of sealing the packaging material; wherein the volume filling ratio of the nicotine pouch filler is 60% to 75% of the internal volume of the nicotine pouch.

[0103] In the step of sealing the above packaging material, a heat or ultrasonic fusion method can be used, and at this time, the packaging material for the nicotine pouch can be sealed by controlling conditions such as temperature according to the type of fiber constituting the packaging material and / or the manufacturing conditions of the packaging material.

[0104]

[0105] Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.

[0106]

[0107] 1. Manufacturing of nicotine pouches

[0108] The nicotine pouches of Manufacturing Example 1 and Comparative Examples 1 to 3 were manufactured by the following method (Fig. 1), and the thickness of the nicotine pouch and the content of the added nicotine pouch filler are as shown in Table 1.

[0109]

[0110] Manufacturing Example 1

[0111] A nicotine pouch was manufactured in which the volume filling ratio of the nicotine pouch filler was 65% of the internal volume of the nicotine pouch and the filling density of the nicotine pouch filler was 0.35 g / cc. At this time, the nicotine pouch was manufactured so that the horizontal seal was sealed in the form of a lip seal, and the widths of the horizontal seal and the vertical seal were 2 mm. The size of the final sealed nicotine pouch was 14 mm in vertical length and 28 mm in horizontal length. The density of the nicotine pouch filler included in the nicotine pouch was 0.54 g / cm. 3 It was.

[0112]

[0113] Comparative Example 1

[0114] The nicotine pouch was manufactured in the same manner as in Manufacturing Example 1, except that the volume filling ratio of the nicotine pouch filler was 50% of the internal volume of the nicotine pouch and the filling density of the nicotine pouch filler was 0.26 g / cc. The density of the nicotine pouch filler included in the nicotine pouch was 0.51 g / cm 3 It was.

[0115]

[0116] Comparative Example 2

[0117] The nicotine pouch was manufactured in the same manner as in Manufacturing Example 1, except that the volume filling ratio of the nicotine pouch filler was 80% of the internal volume of the nicotine pouch and the filling density of the nicotine pouch filler was 0.45 g / cc. The density of the nicotine pouch filler included in the nicotine pouch was 0.56 g / cm 3 It was.

[0118]

[0119] Comparative Example 3

[0120] The nicotine pouch was manufactured in the same manner as in Manufacturing Example 1, except that the volume filling ratio of the nicotine pouch filler was 100% of the internal volume of the nicotine pouch and the filling density of the nicotine pouch filler was 0.52 g / cc. The density of the nicotine pouch filler included in the nicotine pouch was 0.52 g / cm 3 It was.

[0121] Manufacturing Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Thickness of nicotine pouch (mm) 3.2 2.7 4.6 Maximum 5 Content of filler (mg) 3 70 2 70 4 70 5 45

[0122] 2. Experimental Example 1: Evaluation of Nicotine Release Rate According to Volume Filling Ratio

[0123] The nicotine release rates of Manufacturing Example 1 and Comparative Examples 1 to 3 were investigated. The nicotine release rates were evaluated by an in-house analysis method (modified USP4 method) that applied the nicotine release analysis method of Altria. The artificial saliva was prepared according to the German standard DIN V Test Method 53160-1, and the release intervals were 4, 8, 12, 16, 20, 30, 40, 50, and 60 minutes, and the nicotine was quantitatively analyzed using UPLC-PDA using an internal standard solution. The results are shown in Table 2 and Fig. 2.

[0124] Accumulated nicotine concentration (%) After 4 minutes After 20 minutes Manufactured Example 117.57 3.6 Comparative Example 116.07 1.2 Comparative Example 212.46 9.3 Comparative Example 313.86 4.9

[0125] In Comparative Example 1, the initial release of nicotine was fast, but the subsequent duration was low, and in Comparative Examples 2 and 3, the overall nicotine release rate was low.

[0126] Manufacturing Example 1, compared to Comparative Examples 1 to 3, had the highest cumulative nicotine content in the early and late stages, and was confirmed to have the easiest volume filling rate for nicotine extraction.

[0127]

[0128] 3. Experimental Example 2: Evaluation of usability according to volume filling ratio

[0129] A sensory evaluation was conducted to evaluate the usability of Manufacturing Example 1 and Comparative Examples 1 to 3. The sensory evaluation was conducted by oral use by 5 to 6 evaluation panelists. The results are shown in Table 3.

[0130] Evaluation of the feeling of use Manufacturing Example 1 Comfort Comparative Example 1 Difficult to fix in the mouth, slips or moves Comparative Example 2 Uncomfortable due to a foreign body sensation caused by hardness when used Comparative Example 3 Uncomfortable due to a foreign body sensation caused by hardness when used

[0131] It was confirmed that Manufacturing Example 1, unlike Comparative Examples 1 to 3, provided a comfortable feeling of use.

[0132]

[0133] From the above experimental examples, it is predicted that the nicotine pouch and packaging method described in the claims will provide a comfortable feeling of use while having an excellent nicotine release rate.

[0134]

[0135] Although the embodiments described above have been described with limited drawings, those skilled in the art will appreciate that various technical modifications and variations can be applied based on the above. For example, appropriate results can still be achieved even if the described techniques are performed in a different order than described, and / or components of the described systems, structures, devices, circuits, etc. are combined or combined in a different manner than described, or are replaced or substituted with other components or equivalents.

[0136]

[0137] Therefore, other implementations, other embodiments, and equivalents to the claims also fall within the scope of the claims described below.

Claims

1. Contains nicotine pouch filler and packaging material; A nicotine pouch, wherein the volume filling ratio of the above nicotine pouch filler is 60% to 75% of the internal volume of the nicotine pouch.

2. In paragraph 1, A nicotine pouch having a vertical length of 11 mm to 17 mm and a horizontal length of 25 mm to 32 mm.

3. In paragraph 1, A nicotine pouch, wherein the weight of the nicotine pouch is 0.3 g to 0.6 g.

4. In paragraph 1, The internal volume of the above nicotine pouch is 0.8 cm 3 1.2 cm in diameter 3 In, nicotine pouch.

5. In paragraph 1, The above packaging material is packaged in a wrap seal manner, A nicotine pouch, wherein the above packaging material is sealed to a width of 1 mm to 3 mm.

6. In paragraph 1, A nicotine pouch having a thickness of 2.8 mm to 4.5 mm.

7. In paragraph 1, The above nicotine pouch filler is, nicotine; A controlled-release excipient comprising at least one selected from the group consisting of cellulose and sugar alcohols; binder; pH adjuster; and A nicotine pouch comprising a flavoring agent.

8. In paragraph 1, The density of the above nicotine pouch filler is 0.34 g / cm 3 0.74 g / cm 3 In, nicotine pouch.

9. In paragraph 1, A nicotine pouch, wherein the content of the nicotine pouch filler is 280 mg to 460 mg.

10. In paragraph 1, A nicotine pouch, wherein the filling density of the above nicotine pouch filler is 0.26 g / cc to 0.44 g / cc.

11. In paragraph 1, The above packaging material, Cellulose fibers; and A nicotine pouch comprising a thermoplastic material fiber.

12. A step of wrapping the nicotine pouch filler with packaging material; and A step of sealing the above packaging material; including; A nicotine pouch packaging method, wherein the volume filling ratio of the above nicotine pouch filler is 60% to 75% of the internal volume of the nicotine pouch.

Images