Genetic regulatory elements for cardiac tissue expression and uses thereof

Abstract

Provided herein are regulatory elements capable of restricting the expression of a heterologous nucleotide sequence to cardiomyocytes. Further provided herein are vectors comprising such regulatory elements and uses of such regulatory elements and vectors for selective expression in cardiomyocytes.

Description

GENETIC REGULATORY ELEMENTS FOR CARDIAC TISSUE EXPRESSION AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional Patent Application No. 63 / 590,830, filed October 17, 2023, which is incorporated by reference herein in its entirety for all purposes. REFERENCE TO AN ELECTRONIC SEQUENCE LISTING

[0002] The contents of the electronic sequence listing (REGT_005_01WO_SeqList_ST26.xml; Size: 285,220 bytes; and Date of Creation: October 16, 2024) are herein incorporated by reference in their entirety). TECHNICAL FIELD

[0003] The disclosure relates to genetic regulatory elements and uses thereof to express heterologous nucleotide sequences. BACKGROUND

[0004] Gene therapy has the potential to revolutionize the treatment of genetic disorders. Clinical application of this promising technology requires overcoming significant technical limitations. Among these is the need to restrict the therapeutic intervention specifically to the cellular populations affected by the disease (for example, cardiomyocytes) to reduce off-target effects and increase efficacy of the therapy. SUMMARY

[0005] Provided herein is a vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (b) a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (c) a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (d) a reverse complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer havingat least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.

[0006] Provided herein is a vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of any of SEQ ID NOs: 4-18; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 4-18; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 4-18.

[0007] Provided herein is a vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152.

[0008] In some embodiments, the vector further comprises a promoter.

[0009] In some embodiments of the vectors provided herein, the vector comprises, in 5' to 3' order: (i) a promoter; (ii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; and (iii) a heterologous nucleotide sequence.

[0010] In some embodiments of the vectors provided herein, the vector comprises, in 5' to 3' order: (i) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; (ii) a promoter; and (iii) a heterologous nucleotide sequence.

[0011] In some embodiments of the vectors provided herein, the vector comprises, in 5' to 3' order: (i) a promoter; (ii) a heterologous nucleotide sequence; and (iii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequencecomprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity.

[0012] In some embodiments, the vector is a non-viral vector. In some embodiments, the non-viral vector is a plasmid vector.

[0013] In some embodiments, the vector is a viral vector. In some embodiments, the viral vector is an adeno-associated virus (AAV) vector or an adenovirus vector.

[0014] In some embodiments of the vectors provided herein, an AAV vector comprises a 5' AAV inverted terminal repeat (ITR) and a 3' AAV ITR flanking: (i) the heterologous nucleotide sequence; (ii) a promoter; and (iii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity.

[0015] In some embodiments of the AAV vectors provided herein, an AAV vector comprises, in 5' to 3' order: (i) the 5' AAV ITR; (ii) the promoter; (iii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; (iv) the heterologous nucleotide sequence; and (v) the 3' AAV ITR.

[0016] In some embodiments of the AAV vectors provided herein, an AAV vector comprises, in 5' to 3' order: (i) the 5' AAV ITR; (ii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; (iii) the promoter; (iv) the heterologous nucleotide sequence; and (v) the 3' AAV ITR.

[0017] In some embodiments of the AAV vectors provided herein, an AAV vector comprises, in 5' to 3' order: (i) the 5' AAV ITR; (ii) the promoter; (iii) the heterologous nucleotide sequence; (iv) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; and (v) the 3' AAV ITR.

[0018] Provided herein is an AAV vector comprising a 5' AAV inverted terminal repeat (ITR) and a 3' AAV ITR flanking: (i) a heterologous nucleotide sequence; (ii) a promoter; and (iii) (a) the nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; (b) a reverse nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; (c) a complementarynucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; (d) a reverse complementary nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1 or SEQ ID NO: 2.

[0019] In some embodiments, the promoter comprises an RNA-polymerase II binding site, a TATA box, a TF2B recognition element (BRE), a motif 10 element (MTE), or a downstream promoter element (DPE). In some embodiments, the promoter is a minimal promoter. In some embodiments, the minimal promoter is a human beta- globin minimal promoter.

[0020] In some embodiments, the vector further comprises an enhancer.

[0021] In some embodiments, the vector further comprises or encodes a polyadenylation signal sequence.

[0022] In some embodiments, the vector further comprises or encodes a Kozak sequence.

[0023] In some embodiments, the vector further comprises or encodes a woodchuck hepatitis virus post-transcriptional element (WPRE), a hepatitis B virus posttranscriptional regulatory element, an RNA transport element (RTE), a WPRE3, or a wsl3 regulatory element.

[0024] In some embodiments, the vector further comprises an artificial intron.

[0025] In some embodiments, the vector further encodes a 2A self-cleaving peptide.

[0026] In some embodiments, the vector further comprises or encodes an internal ribosome entry site (IRES).

[0027] In some embodiments, the heterologous nucleotide sequence encodes a protein. In some embodiments, the heterologous nucleotide sequence encodes a CRISPR- associated protein. In some embodiments, the heterologous nucleotide sequence further encodes a guide RNA (gRNA). In some embodiments, the heterologous nucleotide sequence encodes a gene silencing nucleic acid.

[0028] Provided herein is a viral particle comprising any of the vectors disclosed herein.

[0029] In some embodiments, the viral particle is a recombinant adenovirus particle.

[0030] In some embodiments, the viral particle is a recombinant AAV (rAAV) particle. In some embodiments, the rAAV particle is a MyoAAV, MyoAAV 4A, MyoAAV 4B, MyoAAV 4C, MyoAAV 4D, MyoAAV 4E, MyoAAV 4D, MyoAAV 1A, MyoAAV 1B, MyoAAV 1C, MyoAAV 1E, MyoAAV 1F, MyoAAV 2A, MyoAAV 2B,MyoAAV 2C, MyoAAV 2D, MyoAAV 2E, MyoAAV 2F, MyoAAV 3A, MyoAAV 3B, MyoAAV 3C, MyoAAV 3D, MyoAAV 3E, MyoAAV 3F, AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAV13, AAVrh.8, AAVrh.10, AAVrh32.33, AAVrh.74, AAVhu.68, avian AAV, bovine AAV, canine AAV, equine AAV, ovine AAV, snake AAV, bearded dragon AAV, AAV2i8, AAV2g9, AAV-LK03, AAV7m8, AAV Anc80, TM-AAV6, AAV-PHP.A, AAV- PHP.B, AAV-PHP.S, AAV-PHP.eB, AAV-CAP.B10, AAV2-r3.45, AAV2-LSS, AAV2PFG, AAV2-PPS, AAV2-TLH or AAV2-GMN serotype particle. In some embodiments, the rAAV particle is a MyoAAV, MyoAAV 4E, MyoAAV 4A, AAV9, or AAVrh.74 serotype particle.

[0031] Provided herein is a population of viral particles comprising a plurality of viral particles disclosed herein.

[0032] Provided herein is a pharmaceutical composition comprising a vector, a viral particle, or a population disclosed herein, and a pharmaceutically acceptable carrier, vehicle or diluent.

[0033] Provided herein is a nanoparticle comprising a vector disclosed herein.

[0034] Provided herein is a cell comprising a vector or a viral particle disclosed herein. In some embodiments, the cell is a mammalian cell or an insect cell.

[0035] Provided herein is a method of producing a rAAV particle, the method comprising: (i) culturing a cell disclosed herein under conditions allowing for packaging the rAAV particle; and (ii) harvesting the cultured host cell or culture medium for collection of the rAAV particle.

[0036] Provided herein is a method for selectively expressing the heterologous nucleotide sequence in cardiomyocytes in a subject in need thereof, the method comprising administering to the subject a vector, a viral particle, a population, a pharmaceutical composition, or a nanoparticle disclosed herein.

[0037] Provided herein is a method for selectively expressing a heterologous nucleotide sequence in cardiomyocytes and skeletal muscle cells in a subject in need thereof, the method comprising administering to the subject a vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of SEQ ID NO: 152; (b) a reverse nucleotide sequence of SEQ ID NO: 152; (c) a complementary nucleotide sequence of SEQ ID NO: 152; (d) a reverse complementary nucleotide sequence of SEQ ID NO: 152; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to SEQID NO: 152; or a viral particle, population of viral particles, pharmaceutical composition, or nanoparticle comprising said vector.

[0038] In some embodiments of the methods provided herein, the vector, the viral particle, the population, the pharmaceutical composition, or the nanoparticle is administered to the subject intravenously.

[0039] In some embodiments of the methods provided herein, the vector, the viral particle, the population, the pharmaceutical composition, or the nanoparticle is administered to the subject via injection into cardiac muscle tissue.

[0040] In some embodiments of the methods provided herein, the vector, the viral particle, the population, the pharmaceutical composition, or the nanoparticle is administered to the subject via injection into skeletal muscle tissue. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] FIG. 1 depicts representative images of transgene expression profiles in the heart and six off-target organs. Expression profiles of the regulatory elements for M1_V1 (SEQ ID NO: 1), M1_V3 (SEQ ID NO: 2), and M1_V24 (SEQ ID NO: 3) (from top to bottom) in the indicated organs upon systemic (intravenous) injection of 1E+11 vg (in 100 µl) of recombinant adeno-associated virus (rAAV) particles (having MyoAAV 4E capsids) containing the regulatory elements into adult mice after 3 weeks of incubation are shown. Representative images show the expression of the viral fluorescent protein reporter. At least 3 mice per condition were tested. Organs shown from left to right are: heart (in transverse), skeletal muscle (tibialis anterior), brain, spinal cord (SC), dorsal root ganglia (DRG), lung, and liver.

[0042] FIG 2A – FIG. 2C depict representative images of transgene expression profiles in the heart and two off-target organs. Expression profiles of the regulatory elements for M1_V2 (SEQ ID NO: 4), M1_V9 (SEQ ID NO: 5), M1_V11 (SEQ ID NO: 6), M1_V12 (SEQ ID NO: 7), M1_V14 (SEQ ID NO: 8), M1_V15 (SEQ ID NO: 9), M1_V16 (SEQ ID NO: 10), M1_V20 (SEQ ID NO: 11), M1_V21 (SEQ ID NO: 12), M1_V22 (SEQ ID NO: 13), M1_V26 (SEQ ID NO: 14), M1_V27 (SEQ ID NO: 15), M1_V28 (SEQ ID NO: 16), M1_V29 (SEQ ID NO: 17), and M1_V32 (SEQ ID NO: 18) (from top to bottom) in the indicated organs upon systemic (intravenous) injection of 1E+11 vg (in 100 µl) of rAAV particles (having MyoAAV 4E capsids) containing the regulatory elements into adult mice after 3 weeks of incubation areshown. Representative images show the expression of the viral fluorescent protein reporter. At least 3 mice per condition were tested. Organs shown from left to right are: heart (in transverse), skeletal muscle, and liver.

[0043] FIG.3A – FIG.3B depict expression strength quantification data for Massively Parallel Reporter Assay (MPRA)-validated regulatory elements. FIG. 3A depicts quantification of the statistical significance of expression strength for 122 MPRA- validated regulatory elements (CV specific candidates) and the set of negative control sequences. The Y-axis represents the maximum Z-score across the four mammalian cell lines (primary human cardiomyocytes, primary human skeletal muscle cells, a human embryonic kidney cell line, and a mouse myoblast cell line) based on a statistical comparison of the test sequence RNA / DNA barcode ratios with the distribution of negative control sequences. FIG.3B is a graph showing individual expression strength significance values for 122 MPRA-validated regulatory elements with maximum Z- score greater than 1.5.

[0044] FIG. 4A – FIG. 4B depict representative images of transgene expression profiles in the heart (frontal section) and several off-target organs (tibialis anterior, gastrocnemius, diaphragm, liver, dorsal root ganglia (DRG), kidney, spleen, lung, brain, and spinal cord). Expression profiles of the regulatory elements for M1_V1 (SEQ ID NO: 1) and M1_V3 (SEQ ID NO: 2) in the indicated organs upon intravenous injection of 4E+11 vg (in 200 µl) of rAAV particles (having MyoAAV 4E capsids) containing the regulatory elements into adult mice (n=3) after 3 weeks of incubation are shown. For each organ, the acquisition settings for each image are identical.

[0045] FIG. 5 depicts representative images of transgene expression profiles in heart chambers. Expression profiles of the regulatory elements for M1_V1 (SEQ ID NO: 1) and M1_V3 (SEQ ID NO: 2) in the indicated heart chambers upon intravenous injection of 4E+11 vg (in 200 µl) of rAAV particles (having MyoAAV 4E capsids) containing the regulatory elements into adult mice (n=3) after 3 weeks of incubation are shown. Acquisition settings for each image are identical.

[0046] FIG. 6 depicts pixel intensity analysis data for the regulatory elements for M1_V1 (SEQ ID NO: 1), M1_V3 (SEQ ID NO: 2), a negative control, and a positive control. “AU” = arbitrary units.

[0047] FIG. 7A – FIG. 7B depict representative images of transgene expression profiles in the gastrocnemius, tibialis anterior, soleus, heart, liver, dorsal root ganglia (DRG), kidney, spleen, and lung. Expression profiles of the regulatory elements forM2-2 (SEQ ID NO: 152) in the indicated organs upon intravenous injection of 4E+11 vg (in 200 µl) of rAAV particles (having MyoAAV 4E capsids) containing the regulatory elements into adult mice (n=3) after 3 weeks of incubation are shown. DETAILED DESCRIPTION

[0048] The disclosure provides regulatory elements capable of selectively expressing a heterologous nucleotide sequence in cardiomyocytes and in the heart while reducing or preventing expression of the heterologous nucleotide sequence in other cell types and organs. The regulatory elements enrich expression of the heterologous nucleotide sequence in cardiomyocytes and reduce or prevent expression in other cellular populations and organs (e.g., skeletal muscle cells, liver, brain, lung, spinal cord, and dorsal root ganglia). The disclosure further provides regulatory elements capable of selectively expressing a heterologous nucleotide sequence in cardiomyocytes and in the heart as well as in skeletal muscle cells. When integrated into a DNA-based expression vector, the regulatory elements can be used to reduce off-target effects and increase efficacy of gene therapy. REGULATORY ELEMENTS AND VECTORS

[0049] Provided herein are genetic regulatory elements for selectively expressing a heterologous nucleotide sequence in cardiomyocytes. When integrated in a DNA- based expression vector, these regulatory elements are capable of restricting the expression of the heterologous nucleotide sequence to cardiomyocytes and to the heart.

[0050] In some embodiments, the regulatory elements do not express the heterologous nucleotide sequence in one or more of liver, brain, spinal cord, dorsal root ganglia, muscle, and lung.

[0051] Provided herein is a genetic regulatory element comprising the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3, a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or a reverse complementary sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.

[0052] Provided herein is a genetic regulatory element comprising the nucleotide sequence of any of SEQ ID NOs: 4-18, a reverse nucleotide sequence of any of SEQID NOs: 4-18; a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; or a reverse complementary sequence of any of SEQ ID NOs: 4-18.

[0053] Provided herein is a genetic regulatory element comprising the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152, a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; or a reverse complementary sequence of any of SEQ ID NOs: 1-141 and 152.

[0054] Provided herein is a genetic regulatory element comprising the nucleotide sequence of SEQ ID NO: 152, a reverse nucleotide sequence of SEQ ID NO: 152; a complementary nucleotide sequence of SEQ ID NO: 152; or a reverse complementary sequence of SEQ ID NO: 152. This regulatory element is a muscle-specific regulatory element driving expression both in the heart and in skeletal muscles. This regulatory element can be used to target the expression of therapeutic transgenes in the context of pathologies that predominantly affect skeletal muscles but also have a cardiovascular component.

[0055] Provided herein is a vector (e.g., a DNA vector) comprising (i) a heterologous nucleotide sequence; and (ii) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or a reverse complementary sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.

[0056] Provided herein is a vector (e.g., a DNA vector) comprising (i) a heterologous nucleotide sequence; and (ii) the nucleotide sequence of any of SEQ ID NOs: 4-18; a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; or a reverse complementary sequence of any of SEQ ID NOs: 4-18.

[0057] Provided herein is a vector (e.g., a DNA vector) comprising (i) a heterologous nucleotide sequence; and (ii) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; or a reverse complementary sequence of any of SEQ ID NOs: 1-141 and 152.

[0058] In some embodiments, a vector comprises (i) a heterologous nucleotide sequence; and (ii) a nucleotide sequence comprising one or more regions of about 100base pairs (bp) or longer having at least 85%, 90%, 95%, 97%, or 99% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.

[0059] In some embodiments, a vector comprises (i) a heterologous nucleotide sequence; and (ii) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85%, 90%, 95%, 97%, or 99% or greater sequence identity to any of SEQ ID NOs: 4-18.

[0060] In some embodiments, a vector comprises (i) a heterologous nucleotide sequence; and (ii) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85%, 90%, 95%, 97%, or 99% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152.

[0061] In some embodiments, a vector comprises 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18 of the regulatory elements disclosed herein. In some embodiments, a vector comprises 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18 of the regulatory elements selected from SEQ ID NOs: 1-18. In some embodiments, a vector comprises 2 or 3 of the regulatory elements disclosed herein. In some embodiments, a vector comprises 2 or 3 of the regulatory elements selected from SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.c g c c c c g c g a a g g C C C G A C C C G A G t ttccgcgagggcccagggaggtctcGGC C T C G C A T C Ta t t g t t a g g g g c c CCTTCGGCGGGGTAAA A Tg a c t a a c a a g g c gC G Tg t c ct C G C C G G A A A T Ga t a gcgtaccgaggtct t a c C C T C G G A T G C Gc c c a t t c t g g cccctgattGAGCC G C A G A A A Tt g g c t t c c g g c g t c c C GCGCCCAGGGGA T T Ga a g c g c a t t t t aC C A At tc g g G T C G G G A A A C Ct atccttaggcct c c c g c a t G C G G G A G A A G Tt a c c t g ccgcccgttacata t A G C C G G G A A G Ac a c g t t c t t a c g ctataGGCGCCC T C C C C T Tg t t t t a c t c g c a c g c G G CTCCCCGGCTATTT Ct t g c g c c t t a a a cA Gc t ta a T G C C A G G A G C Tt t tccgtacacactcc t t g c t C A G C T C G A A T Tc g c a c c a a cgaccaggtggt A A A G T C T A A G Ac g c a g a a t a a c a g acgGGCCGGCGGCA G T A G Cg t g c a g c t t t g c t g t T C G C GAGGGCGGTAAAg c a c c g c c c a g g a g tGt t t c aG A C G C C G A T A Tc c g c gaggagtccgat g a a a G G C T C G C C G G Ag g t c g g c t g cgtagcacatcAAA C C C C G A A A Gt t c c g t g a g g a g g g t CGGCTGAGGCGT G C T Tt c c g a c a t t g aC A G T Gga g g a A A A C C G C G T C Agtatttcgagat c g a c c g t c T T T A C A T A A C Ag t g t a caatataggagaga c c C T C G C C T A A A Gt a t t c g a c a a g gccgggaAGTCC C G C A G A G Gc c a c t a a c c c g t g t g T CGGGTGCCGCAAGC T Ac g c c c g c g a a a cT A Gg ta g a A C A C A G G T G G Ag catcctttccgagggggccggccgacgGTTGCACTTAGGCG CG C T Ga c g c a t t a g t g tA A C Gc c g c g a c c a c a ggacgggAATTG A T G A C A C G Ac t g t g t c g c g c g g a a A TTCTCACCGC G C C T Tc t g a a t a g c g c a g t c T G C T C GGGGCTAGTGAAt g t c c c c g g t g c a tGc t gt G A G G T G G G A A A Ac c ccgtagagga a g a g c t g G G C T C C A A A T A Tc a g c t t tctccgagga a a a T T G T A C A A C G G Ag g g c t a c g g c attggtaaaCTA T G C C G C A G A Gg t t a t a c a a g c t g t a CGATTACAGA A A T T A Tt a a c c a c a g a a a a c t G A C C GGGGCGGCAAAA Ac c t c g t t a g t g t aA Ag gt a G A G G C G T G T G C Aa tatcctcttgta a t g a g a c A T G C T G C A A G A Tc t t c t t ttacatagat g c g C A A C G A G G T A C Tc g c a c g c c g t actggttggGAT C C G C G A A A G Gni c t g c c g c g g a g a g a t CAATCCCG G T C T A A Tot tcatggccggtcgagggatcggctgaagcgGTATGTCGTACAAAATGAAC G T GGAAAAT Aatngett t c t t t t a t g t g g g C C G C G C A T A ATCGTictcgagccacc c g c g a g a t t g C T T C G T A C C C A Gagtgttcg g c g a g c c A C G G G G C C A T T Ar c t c c t c cggggtta g g t t A C C C G G C A G G A Ao a c c a g t t c g agtgtggctc G T C T G T C A A A T G'3- acgaagacggattgtcgaagggctggcggaAgTAACT C T T A A G G T TTCGCCGGT C A A T T T'5cniccagacgtcactagagtgtggctcgacagAAACACGCCCGTATATCAG A A TTGAAAGGTAecccgncgg a c g c c g c g c t t g T G A C T C C A C A C Cggtcgggtca c g t g g g c g A G G T G C C T C C A Cegutaqcgcgatacctcgcgcgcgc c a a c g T A G C T T G C G A T Agtcgtctgga g A C C G C C T G G A A CetataaccagacactttgggttagccggagcacgcggagagggaGagTG G C T G G G A A A AgGGATGTAGGGCCCC A G G C A ACCCTCC A A C GS c t a a c t g c t t g g g g g C C T C G A TGCGTAATCAAezislato)p 7 7 0 9Tb(75055535OQNE2SDI 1 251 3e 1mV34V2Va_1_21-2_1N M M M MA T a g c a t g c g c c c t c c a c g a t c g g A ATCcgagtaccctggcctcgggtgggccgg c c t a t t a tC G g g t c g g g g a g g g cagccttactggggtcacT T g a t g a g c g c c g c ccA T a g g g tg c a a g a t g gG T c g c g tacgcgcccaccgggccc c g c t t g a tA A t a c a t g a t c c g g agggcttagagatttt g gA A g g c c a g c c g a ac a aC T at g g c c t t t t c c c tA A aggccgatagttcg a c c c c g c t a a t g t g a tA A a g g g t g cacacgacccccct c t c g g t t t g tA G a g c g g a c t c g a g cctagcgcaaaaat c g g cA A t a g t a t c c ct g a t gAg a a g c c t a t g a t t a gACAaccgcacgcaa g c c c g g c g c t g c t a t t g cG T g g c a gcgcctggggcccg c c c t g g a t t t a cA G g g t c t g c t g c gcgcgtgccacgtg c c a c a cT T g t c c g t c g g g g t g c g a tacaccacaggaatG A t g c c g c a t c a a g gtT C c a cg c t g c a g t c a cT T g t ctcagtaccctccg c c g c c t t c a t t c c gG A g a g c g t c g gccccaccgggccc g t t a c c a tA A g c c t a t g a a c c c g g agtacagtaaggtt g cA T c g c g g g g t c g gt a cG A ta a t g t t t c t t c g aT G cgtcctggaccgat c a a c c c c a g g t t a g g cT A g c a t g c ctatgaccacgac c c t a c g t t t a aT T a t c c g c g t c g c c gcacgccctaaa t c c c g cA A A a c t g c a a t g c c g a a g a actgatctacag cA A G t c g g g g t t c c ca cG A Ac g g c c g c t t c c g cA C Atgggatgacgg g c g g g g c g c c a a t t c a g tT A T c g t c ctcacgtggccg c c c c g c c c t g c g cG C A c a t g a g a t g cggcggggtgga c c a c a c t cG G T c c a g c a g t t c c a a g ggaaaacggttg c g cA A A c g t g t c t a ca c g cAa c g c c g c a t a c c t g cATAATcgagatt c c g c t g c c c a c g g g g g g c g tG C G c g ggaccctgaatc c g c c c g g g g a g g c g cT T A g t a t c c g tgcccaccgc c g g t t a t g c t cT A A c c c a g c g c t c c agaacacaccag a c a c g cT A T a g a c c t a g g c g c a g c t cgatttactctg cA A G c a g g c g g t c g ag cA G Gc c a c g g g t a g c g tC G T ttccctggtc t g t g c g c c g a a t t c a a c a cA G A c c c g ccagtagatc c g c c g a a t t g a a c a cA A G t c t a t c c g cggcccgcgc c g a a c t g a c a cG G G t c c g a c t g t g a g cgggcccata g t t a c c aA A A c g c g t c g g a t g g c g c g actgcccggt t a cn A G G g c t a t g a g c c c g c g g g c t t a aacccgaccoi At AGTTA t c g g g g t a c c c t c c a a g c c a g g c c cACAttc t g c g t c g c c c a c g c g a c c a g a g aatnAeGTAAAaccagctacgc a t g a g c t g c c c g a c c c g c g cgcccgatg g a g c c g c c t c c g c t c c aiTTGGGAatcctgggcgagagttagcgggc g c a c c c t t a g c c g gcccctc c g g g c a g a g c g tr T A G t g a g c g g a g g g gcccgaca g g c t a g a t to T T A c g t a g t a t g t g c g a cacgctca t c g c c a'3- AACTTGgtgattcgcacgcaacacgcgggcccggcccctcagcggtttttc a c attcgtt t'5A T A t c a g c a g g t a c g c c c c g t c g a g taaccniAeAAcGTAAa g t g t c t g g c g g c g g g a c g t g a a g cnGAAAtTcatgagtt c c g t a c g g a g c g c t g g a a a g aggaccctg c a a a t g g c g c t t t t c t t ceTuTAqGGTTactcactacgcacgtgaatac c c c g c g g t c g c t c a ttgaccccc t c c a c c t t t c g teAGAACGCcCggaaacgctgcgctcgatgtggaccgggacagcgaccggtaccgc g c c g a a c g ggcccgcactctt t a a a a atgaaat t c c gS T G A g c g t c g a c g g c g c c c c g t a gactcttcagaezislato)p 7 7 8 0Tb(55755315OQNESDI 4 5 6 712e 2V9V1V1ma_1_1_V 1_1N M M M Ma t g a a t g t a t t t t t c a t t c t a c t c g agagttcaatcacggctagtgctact c c t a g c t c c t tc t a t a t a a t g a a cattacaggggtat t c g a aa t g t g g g a g at c t a c cga c c g g a g g a t g g c g cgtcaacggagggag a a a c a g g c t t g c a t c t gt g a t t a ttagaacaagaacg g c g c g c g g c c aa g a t t t g g c a a g ctgtcccggccgtc t g g t gg c a t a t g a g cc c t g a aac a c g c g a c t c g t t c cacccaacaggttgg a a g c c g c t t t c c t c t c ga t g a a t tgggttttagggta c c a g c g c c c t ga t a t c c g t g g c g ctatgcttcact t a c t g g ga c g t t a t t g a t a c t a g a cctttcccgtaatt ac g g c a a g t g a t c tc ca t ac c t g t t c t a c t a tg c ggtctaagtaaggt t t g a c g t c c g g c g t c ga c g t t c a t gcttcgatggtt a c g g a t c t a c ag a a a a t c c a c a a a ccgcttcgtttgtg c c t g ag c g t c g g a a a a a c t g g t g t cgtggtatcttaa a g c a g t g t a g a t cag c g tt g t t a g t t c c g tg c t attaacagaaaa a t g t g g t c c t c t c g a aa c g c t g t c agttcacggtttca c c a c c c t g c cg c g c a t c c a a c g a c cgatgccttcct g g a c gg t g g g a c a t g c g g t c g t g c gtaattcggcggg c g a t g g c t a g g a ggt c g gc t t a g a c t a g a tg c t agttaatggtcgta t g t g c a c t c g t c g c cg c g c a g g a g ggtcgtctaact c g t c t a c g g gg c g g a a t a a t a g t c gccggtgatcgc t g t g gg t g g t a t a t a g g c g t g a g c gtatcttccgggg c g g g g c c t g t c c g gct c a a tg c a t t c c g g g tg c a c tatctgatctta t g a g t g c a t c g a t a cg c a t g g c c g cagcggtcgaccta a c c t g c c a gg c c g t a a c t a a a c a a ctaaacggagta c c g ag t a a g g c t a t ag c g g cag t t a t c t a t c g g t g gaccgaaataaat a c g c g c a a c a g g t a g a c g aa c c a a agtgggattttg t c t t a g a t c g c c a gc a g t a c a g t c tttctaaggcct c c a c g g c t aa c g a c g a a t a a t c t c gtaccggttgttcg a a cg c c c a a a a c a cg c t caa c t c g g a g c t c g g a ccccgggggaatg g g g t g g a c a g t a c g g g g t cg a t g g agagtggtattg g g a g a a c g a t a t a gg c c t g t a t a t taaaggatacgcaa t g c c a t t gc a c c t c a c g g t a c c a t caagaagcccgg t c tg g t g c a c t a a cg c t cn t g a a t c a a g g t g g g coi gt ttctaaaggga c g g t c t a t c a c g t a g a c g a t tcttgaaaagt c t c t c a g a c a g c c a g a tatncetatgttcctatatcccgtgttcct c g t t t c t g g c t a a t tttttcgta c c a t a t g a a c g c ciaaccaggattgatttaagtgtttcttctcacatc a a c c g c t c g c tatctac g c g g a c g c tr g c g g g c t c a a t g c t t c c tcaggg g g t c t c co g a a a g c a a g a g g g c a c a c a ttcaat a g t c g'3- tactccggttttgaaggacgactattcatcaaatagctcgcggtgttccg c c tttcctg t'5g t a a t t g a g t g a t a a c c a a g t g g g c tactanigeagccac g t t g a t c g a a t g t c c c g c g a t t t c cncgtggatct t a a a c a a c c a a c a t c c a g a t c t aacggtaaa t g a c a c c c t g t t c t a a t g g teaucaqtgtggattgttttttcca g a t c a t c t g c a a c g c a t tttaaag t t g t g a t g c t c g c g g cegatctacgcatcttgtatagcagatgatcattactagc t g g g g a g a c g c t g gttgtgaggtagg a t t g t c t c c t ttgtg a g t a g t c g t tS t g g a t t t a t a t t a g g a gtatttctttcgtcccgtcccatezislato)p 30991Tb( 6 435OQNESDI 8 9014e 15161mVa_V 1_V 1_1N M M MT T G C C C C C C A T A G C G A G G C t G A G G G G ATTACGTTAGTCTCGCTTTTTGGAGTAACG A G C c C A C T GA A A T G C A G T T T T T T AGGCGCCACggCGTTCGC AC A A A A G G T T G T T T GT GT C G A C TG C G G A g G G G A GT T T T C AAGTTCTTTTATTTTA T C A A G c A G T G TA G T T T C A t T C C A A TtcGGGAAAGCACG t A T G A GG A T T T A A c A T T C G A t T A A C CTGcgACCCGGCGTA A C C T C A t C G T G G T tCA A T T GA C C A A G a G T T C TC C T C AGGCAtcAATTC G A T c G C C C C C T C G C G TA T T T G T C g A CGTTTAATAgtTCC G A A A C C T C C GT T T C A T T t G C T T G G t GTATAGTGTCGTAG G C T GG C G A G G A t G C TT C G C GTC G T t A G G A G G G C A G A GGTTTACAGTTGT t G C C G A T a G T T T T G T T C G G GT T A T C TTCacTTGTGGGTA T c A C G C C A T C C G A GG C A C C T T a A C G TCCATatAGGTTAC A G C C G C C AT A A G T T T t A T A A C T t G A CGTGTAACGTCCTA C GT A A T T C T t T T C G TC G AC GA c G A G C C C T T T C C GT ACACCACTCAGcgT T C A C T g T G G T C T T G G G G TA C T G T C G tCAGTCTAATTAAt A T A C T T T T G A G CC A T T A C G t A A C T G AtaAAAACAACCGG C C G C G GT A T C A C A a A T A G G A t A A C A ACCGAGTGGGGC GC G A C G T C t G T T G T TG GT G Tc A C G C C C C t T G G C AG G ACGTCTGTTctA G A T G T t G A G A G A T c T A A G CG A A A T T T aCGACTTGGGAA a A A C A A C G t C G A A CT G G C C T C c G T T T ATTccAAGTC G G G G t G G C G TA A T T T G C c G C G C C G g A GGATGGCGGGAc C T A A TA A A C T A T g G T A T G T a A T C T T T GgtGGTGTTCTCA A T A G C T a A T C A A A gAA A A AC A C G G G C t G T C T GG A T TTGGTTTgaACT T C A A a G A T G G G A t A G C G GG A T T T T C c GGTCGCGTAATc T A A T T T C a G G T C AG A T T C A T g T A T T A TggCACCCACCG A T c A A C C AA G A C T T T g T T G T T A g T C G ATAAGCCatTTC C G CTCG A T T C C g G T G C G T a A T G A G G C t TGGGCCAGAGGGAAATCCG T a G G G T T T c C C A G G G C c T G T G GA G G C GTTTTctTTACT C A T t T C G A A A T g T G C C TA A T T T C A g C TTAAGAATGgaA T C C C C T t A G C G GA A T G C C T a T C T A A T aAGCCGACTA C T t T C G A TG A T A T G C a C T G C T G a T C C AAAAACCatTGT G C CA A T C C A C a A C T GT G G GAG A a T C T A A A T c A G C G GTGGCTTTGGGTG a A A C G T A t A T A C C C A t G G T G CT T G A T CTAtaGAATG T A T a A C C A C T A a G G C T TT A T C T T C c T ATTCTTAATcgA G T A A A G c A G C C Cni C T T T G A C g T G T C T C gTATTCAACC C A c A G T G Cot TTGTAGAAACAGGGggATGACCTTGTGTgtACCCCCTCCCACCCCAgAaA G G G GgGGGTTGG CatnTeCA T A G C A t G C G T T T c G T A C G A G a G A GGGGGiTTAATCCCAAGTAC G c A C A T T T g A C G G T G A c C T G A CTCTTCggA T C C A G g T G T G C T C g C G C A Tr A A A C T T G gATTCTTG G T g C T G T A A C g G G T G Co T A T A A C A c A G CTTTCAGctT C A G A A G g C G C G T'3- TTTTCTCTTTCCGGtcAAGGAGTCCTGAcTgAAACCAAGATC T T a T T T G CCCCCGCTc G C G G G'5AiGAAACCATTGTGTgaCTGAGGTTA A a A C A C T C CtgGCGCCGCCCGn A A C A T A C G T T a T G G C AeAcGAnTACTGAAAC C T C G C T C C A T T C G C A A A a C G G T ACTTTCTTAAG T C T A G C A C G G C C C a T A C C CeCuAGqGTACATATACGTCGCGGATGTTC T G T A T C G G G A a G G C C GTGTTTACGAA C C T T T G t G C A A AeATCCCAAAATCTGCTTTTTACTTTTCATAATGCAGCAATGACAACGCAGAATAGCGTA C G a G C A C GAAAAGGAGTATcGgA C T C AgGGAGATC CS T T G T A A C T A A T C G C A T T C G A G T g G A TTCGGezislato)p 7Tb(75508550574OQNESDI112131410212226eV V2ma_1_V 1_V 1_1N M M M Mg G A A T G c C C G T C g C A T A C t C A G C C a cACGTGGGAAGggGCGGTCCATCggGGA G C G a A A A T Gt T C G G G g A A C G A t TGAGAACGGccTAATG G Gg A C A A T t C C T A CA A Ga C C Ac T G G T A g A T A C Aa C C GAGGGcgAAGAACTCC g G A T T T a A T G T Ca C G G G T g A C T CTCggACGCGTGGGTg A T A T Ga T C G G C g T Ga A G A G GtC C T c G T C T C c A T A G AaCCAAGGACGGctAAT G T T t A C T T G g G C G C Ac A G T A G c AGTACGACCcgAAAAG A G g A T T C Gg A T C G T g A T C T T a G GAGGGGAgaACATTCT Gg C A G A C a G G T G C GA Ag C C G GG A T G C c A T C C At G A G ACGTTTGATCCTCTTT A T C A C t G A G G Ac A G G C A T G T C C TCGCCTTCGAGACgaA T T A Gg C T G G G A T C AA G C A Gg TT G A A T G G C a A G A G Ag ACAACGTACGGAGAGT A C C C T T G C a A T A A Cc T C A C A A A TAACTTTACGAACTGA C a T T C G At A A C G C C G C A C C C A C TGACCtaCGTTAGGTCc C G A G C A C C T G C A TCg A T T G CT T G G c T A A A Ca C C G A TGGCTCGTCAACTGAT A C A T g G G G G TG G G A G T A A G T C C GCTGTGGGACAggCGA G A TG G A C A C T A T C TG T C TA T CC T G A C C C t G A A C GC A GGGACTTAGTTCCGGA T A A A C G A c A C C G TC C A G A T G T A AAACCTCtTTGTTTA G g A G A G GG C A T T C G t T G C T C C c A T TGGGAggCAGTA G TC T T C C C G c A G G CA A TG CA T t A T T T G c T G C C AC CCGTAGATATAt C T T G C T t T T G C T t T T A A TA G A T T C TtcATCTAAAAA G c T T G G A c A A G C TG T C T T G G g C C T ATCTTgtAATAT G G g A G T A TG A G C G T T t G A C C C G t T GCGTCGAaCAAA A C CG C A T A A T t T T CC A C CTT C G t T T G A C G A T A G GCAGAAACGAAGG t G G T G C T a C T T G C T A C A T AC A A A C GGTacAGTCCGACC G c A A T A T A C A T A AT t T A C A A T a G T T GTTTCatCCA G C C G G G G C CC c C A G T T T t G C C G C T t CGTGTTTGAG A A G T AC t C A G C G A t A C G T C T c C C C G CGTCTTCTAC CT t C A G T G G c A T C AA AC cT A g T C T A C C T A T A GT gGTAAACCCG G g A A T G T C t C A A C G T T A G C GT t C A C GGAGGttCAA G A C G t C A C C G C C G A A TT t G A T T T T a AACGTTCTCC a T G T A G A G A A G AC t C A T A C A t A A A A CCCtcAAGGG A G C T C C G CG a A T T C T A c T C A C C T t A TCGAGTAACC T T G GnC c A T C C A C t A T G G T T a A T A G A GTGACAAG Aoit C a A T G T C C a C T A G C A c G C C G G G t T G CAGAAatG t C T A A C C c T G G T C T c T C T A A G c A A T G AnAeAtiGcA T C C C A c T A G G T C g C G T G T A t C C T G GGgCtCCGGC T G C g A A A G A A a C A C G C C t C C T G AAGGG G C a C C G T T G g C A G G G C c A G G A Gr A t A G GAGGAC g T C G T C G a C C A A A A g T A T A Ao3 G a C A T T TTCacG T T C C T c C A C A C C t T T T T G'- A5 TtcTGGGACAGGAACgCgAACCC A C T g C T A C C A t A A T T AGGGC T C g A C C G G A t T C T C G' A t T C C G A T g C T TGGCCC g T C T G G C a C A A T AiT a C A T G G C a T C C A TCCacG G G T A C c C G G T CneGcAc G G T A A G c G C T C C A tTACCT C A G a T A A G AnCcgGTTGCTTTGAAGtgTCCTCCGACTCCgaCCTACAGGAC G t T G A A GCTGTAt A A G C AeAuTagAAAACCCCCCGTaaGTTGGACTCACCaaCATTACCTGAGcTgAtCA T A TTACCAT GqG a C G C G C C a T T G T G C a G G C T C T t C C TTAGAeA c G A G T G G a T G A T G A t C T C C A G a C T G T GSGAggGTAGTACGACTCtaAGACTCCTGACCacTACCCGTCCTGAtcATAATATCGAezislato)pTb1 2 9 6(84845456OQNESDI5161718178 9 2e 2V2V2V3ma_1_1_V 1_1N M M M MT A G A C A A T G g G C C C A C G A C T A A A G G T GGGATtcAAAGGGGTTTTTtcATACG A C C G T T T C A C A TA A C t C T A A A T g T CAGAAGACCTTCAC C T C C G CTCA T t T A G A G T g C T G G C G A AACCCACGGCCGAGGTATCCcgGCGTA A G A g C A G G G T A T T G C G C G GC A G t A CGGACCACCctAAC T A G C T G C A C A A G CT G T t C G A A T A c CTTGGCTACCCTTG T C A T C A TA A C t C T T A A C g C A G A T T TGTGGCTATTACCGGCG T A a G G A A A A a A C T CGT T T c TA C T A G C T T C G AG G T a AAAGACAACAGGAC A C T T C A C A A C C T A AA A T t T A T A T A ACCACAGGAACCTT G G A C A C G CC G G t G G A A C A T G C T C G GGGAGAATCACTTCTG TG A T c G A G C G A G A A CT CA A T gC A G T G G G C T T C GC C G tTAAATAAATACATTA C G C T A T G A G A G A G GA G A t A A A A C G TCATTTCGGCTCTA T T A G T A G GT T A a G C A A A T G C A G A T ATACATTCCGGTAGGC AT G C t G A T T G C G G C AG CG T G cG C T A A T G A G T G GT G G tAACGTGAAATATT A A T T G T T T T T G G G G AG G G a A A T C C AGACGACCCCCAGT T T T G A T C T AT T T c G T G A A C C A C C G AACAATTTAACTATTG G CC T A c A T A A A G T C GG A TT C CG G A A G A A C A C G G CC G TgaAATCGTACACGTA G A T C A G G T A G T A A G CG G C g C A G T T TTCtcACGGC G A C A A A T T C G T G TG T G a T T A A T A G t G TCTGAGGCCAAT A G A T A G T CA C T c G A A A G C T t T C G G G T ATGTTGGCGA C A T TC A A g A T G A A T T c C C T T G C A A T A GATCGCATTTG T G g G T T A A G A g G C GCA G GA G T C G T A T T G G G GC A TgaTATATTTCA G C t G T G A T C C A T C A A T A A TT A C c A G T GGTAAAGttG T A C G T T T T C A T C C G TT G G t A G A A T A T aGTGTCCCTGAC T A G C G C C G A TT G T g A C C C G G A c C C T C CTATTTATTG A A A G C AA G T a C A C A A A G a C T G A G C T A TTCCTTTGTGGG CA G T a A T A G C T T t A TA AC AG G A C T A A C G A T T A TA CGGaaAAAAC A G T G t G C A G C A T T C G A T C A A TG G T t C AAAGGTACCA c A A A G G C T T A A G T C G C CG G T a A C G A A AAGgtACCACGG A A G T T C C A A C T GT G G c A T A A A G G t C G TACATGAGTC A A G T C A T TC A G g A C A T C T A a G G C G T T GAACTGTTATTG T G TTGT T g C G A G T A G t G C T C A A A T G G A GGGGAAAATATATAgtAAT C T G G A c A A A C C A G C G T G G A A C CA A G c AACAGTTCAT G t G G A C A A A T A C A T C C A TC T G g A A T G CCGGAacGAG T C C A C C C T T A T G T Ani A T T g T G C G C T T c CGTAGCTA C C A A C C G T G A Cot G A T g A A A T G G A g T A G ACATAAAATA C A A A T G CtT G T c A T T G T A G a G G T C C G A TGACCT C T T G GanT G C t C C A A A A A g A G T C A G C T A GTGGACGGGA AeT G G c A A C C T A T a G G C C G T T T T T G T A AAAGAiCGTCAAg A A G T G G A c G G A T T C T A C G A T C C A Cr A C CaTACACG A G A G g A C G T C T G T T A A A C A C Go T C A C T TTTTCTAA T g C C G G G T G A T G A C T G G G'3- TCGGTATCAATGACGTAAGAACAgAaC G G T G A T T T G A T A T A GcTTTCCCA G C A T T T G A A A G A'5GATCGGGAAAAATGTAGAACTTtgAATCTCAGTTCAACG G T C A A C A A CCGAAGGTGGC C G C G TnieTcATCGATTTCAGGACAAAGAGTaaCCGGCTCTCTACAAATTGACCCTACTGAA A GCTGCTAAnAeATuTGTqGGTG G T A G G T G a C A G A C C T T T C C G A G C AGATACTGA T A T A a T T A A T G T A C C C A T G G AeGTACGTTTGAAAGAGACAAGTGATTAT G t C C G G C C A C A A C C C T T TGCCTATTGaAcTgAC A G A T C A A C G A A A A ACAAGTG C T G T A T G C A G G CS A G G A G T C A G A A g A C TCCCATCTATAATGTTCAGACGGAGGGezislato)p 71Tb(54511OQNESDI91024e 2P V VMCm _L _a 1A1N M1.GRR00G C A C C G A G A G C A G G A A T A C A A T T T A A A CGACAGAACTGGAAGCATATTC C C T G G G C C C A C C G TT T T C C T A A A A CCAGACAATACT A C A G A G C A AT G G A G T T A T C G A G T G TGACCCCGATTATT A C CA G G A G T T C C A TT T A GGG G G A A C G T A T T C C C GTTAATCTTCGTTGA C T T G A A T T C A G G T A A T T GG T T A G C TTTGTATTAAAACC A C A A T A A A A G T TT A C T A G G A T A C C CTTTTGACTCTTTA G C A C C CT A C T C G A T A A A C G G T G C C TAGGTAATCTCG GA C T A C T C A A A T A G AA GC C T CT A G G T A C A G T T GA G G GGCCAACAGATA T A T T A A A T T C G T A A G CT G A C G C T T CATCGAACTAACCA T G T A T T T C T TG T C G T C C A T T T A T C TAAGGCGCTGAA G T A T CTGC T A C C T A C T T G A G T T G T A TAATGTTTCACGATGCTACATTCTG A C T A G G C C A G C A G C A A T G GA G A G A TACGTTCGATCAAT T T A A A T T C C T G G AG T A G A T A A T G T GTGAGTTAGTTA A A G G C T G CA G A T G T T A C G A A G T A T CGACTAATCAATCC T TC T T T A G C A C T C TA C TA AT G A A G A G A C T T C T CG GTTTACCACTTGAT A C C G G C T A G T C C A T G G TT A A C T C G CTCTCGAGTGAT A T G G C C T A T G G GT T A C T G C C T A G G CGCAATAACTATCT G T T T A TT C A C A A A A A T A T G A A A G A GGTAGATGTGGCTGA T G T C C G C C A C G T A TTC A T C AA T A T G A T A A C TT A T G ACCAAAGTGCCG G T T T G T T T T T T T C T TC G C G T G C T A TGGGGAAGATTAAT C A A A C T A C AT A G T G T C C G T A T A C A CCGACCCTCTTGTG G A CA C A G T A A T T T C AT T A CCT C C G G A T T C T G T A G TTGGTTACCAA G T C A T C C A T T A A T A C C T A G A CA T A C GACAACAAAACG C T G A G A T T T T C G G A C TA A A G A C G G G TAATGTGAGTAT A G T A T T T A T C TC A A G G C G A T A A A T A GCAGATCAGACG G G A G A CT T A T C G A A A C A T A G A A A A A GCTTCTGTAA C GT T A G C G G A A A T C GC A TA AA C A T C T T A T T G G A TA GATTAACAGA G T A A A A C A A C A G G T T G A C C TT A A C G AGGTACCTACGC A A T T A G G A T C T C T G AT A A C A G T C T A GGCGGGTCCT A A T T A G T T C T CC C A C C A C C T A G T T A CTTCGAACCTAT A T T A C AA A T C A T G G A C T A A G T G G A C CTAACGTCAAGA TC G T G G C A T T A C G A TC TT T CT G T C C G A C G C G C CA C AATGGTAGTC C G G T A C T G A T T A C A T T T T GG A A G T A CCTTCGGGGCAG G G A A C T T A T G T C G Tni G C T A G A G A C G C GGTGAAAA T A T T C A T C T A Tot A T T C T A G G A A T A T A TTTCACCCAA G A G C C G AtT A T T C C A G C G C C T G G G A G AGAACA T T C A TanG G G C T T G G C C G C G C A T A T T T TGTGTTCTCA CeTiTA T G C A G A G A A A A G C G A C C T A A G T CGATAAACCGTGG C T C G C A T G G T A A A A G C G T G A C Cr T T A AAAATGTG G C A C G C T A C A A A T A G T C C Co A C T A A A GAATCTATTA T G T A A A A A T T G T C C G'3- TCGTGCCTGAGTGTATCTAATAAGAGGATGA A C C C A T T G T C G AGCATTATC T G G T T A C G G'5CTTCATTTCAACGGCCGAAGACAGGATTATAACGAAAAATCCG T T C A G AATATCTCAAT A CnieTcTT A A C G G C G G A C A G T A C T T A G A A CCTAGGGnAACCCCAT G G T C A T T C C G G G C A T A A G G T G GeAuTGqAGGGCACTTTCTCTT C A A T G A T T G T C C G G A A C A AGTCAGAAAAA A T A T A A A G T A T T C C CeAGCATACGAAATCGCGTTGAATAAGATGACATGGCAGTGTGTTGTA A A C G C G T A G T TAGGTTGTGAATGTGG G C T A T G GGATATG T A A G AS A A A T T A G G C G T T A G G G A A C A T TAATAAGGGGTAAezislato)p 453Tb(0811OQNESDI1222P PeMV C V _MCmL L _aGA20 GA3NR R 0 R R00G G G A T A G C A T C T T T G A T G G C A G A A C GTAGTAAGTGTGTGAGGAACTA A C A C C G A C A A C GA C T A G A G C T A TATATGTAAGAT G A G A G T AT T T T A A T T G A C T G T G CCCGAAAAACCTCT CC G T T A A A T T A A CA GT T AA T A A G T T A A C T GC C CCCCTTATTCTAGA T T C A T A A A A G A C A GT G G A T A A T ACTAAACGTGTGGG C T C T C A C AT T C T A T A C T G T T C C TGATGTAGGAAGAA A CA T C T A T T C A T AC G TT TC A A T A T A G T T A A GT AGATGAAGATTTAA T A C G T C A G C T A A C C AA A T G A C A TAGGTAAAAGTCAA G C A C C T A G AT G T T C C T T A A T C A GGGGAACCCGGTCT A T AA G T T T C C A A AT A G AGC A A T A C G G G G T C T TGAGTTTTTATTAGA A A T A A C G A A G C G C G A AT A A C G T AAAGTCTAAGGAAG A C C A T G A T A CT C T A T T A C T C T T AGAGAGGTTGTCGA A T G GACA T A C T A C C T A A G G A G T C AAAGGACAAGGATCGCGTGTTTA T T T T A A A C T T G T C A A C TC A T A T TTTATGGTTAAG A C C C G G T G C C G CA A G C T T T G A G TAGAAGTTTTCACA C A G G A GC A A A T A G T A T C A T G C C AGTCACACCTCC GT C C T A G T G T C A A GC GA G A AG A T C C G G G G A CA T C AATTTGTTATACCA A T A G C G A T T T G G TA T C C T G A A G TACATTTGGTGACG G A G G A A CG T A T T G A A A T A C C A G ATTAGCTGATTA C GA A A T G G T A T C T CC G AA T CA A G A C A A G C T G TA C TAAAAGTAAGGACT G T G G A A G G C T G G T CG T C A T A A A GTTTGCATTGACCA G T G T A T C GA G A T T T A C T T G T T G GTTGACTGTACG T T AA T T T T T A A A A TT T T AA AA G A A A C A C C C A T GA GTCAATTAAATT C T A G A G A A C C G T C A C A TA G T A T T TAGATCTGAATA A C A G G T C T C G C CA C G T G A C A A T A AGTGGCAGGA G T T G A T T AG A A T T C A G C T A G C C T GCTTGCTTCAAA C A CAAT C A G C G A T A A T G G G A T T G G CGGATTCTCAGAGTCCTGA A A A G T G A A T A T A A T C A T C AA G C T TGTCGAAATT T A G A A A C G A T T G C T AC A T C A A G A ACAGACTGGCGA G A A G T C A T G AA C T T T A A T T G A G A GGGCAATAGTGA C A A G CA A C C A G A A A A A A A G T A C G ACAAAGAGAG G TA A T G C G A A T G G C G A A G C A C T T T TACACCTn AACCATT C A C A T G A G A A C C C C C T A A G T T Toit CATTCCAACCTTTTT T T A A A G C A T C G A C C T A G T CCTACGT G A T G C G A A T T G C T G T T GatnAeATTGACATTCAACCTAATTGA A T A A T C A A T C G G C C TGAGAGGGG C T T A T T C C G G T TiAACATTCGCGAAGACCATGTACGGTACGTGTGTTC A A A T T T A T TGATTGC T T C T G G Ar C G C A A C A A A C T T G A A T C GAGCTG T C A T Co T A T T T T A C T T A C T A G G T A T AGTGAGTA T A'3- C C T A T T G A A C C T T G A C C A C C C G TATAATT'5 TAC G G A T T A T A A T G T C A C G G C G T T G G CiCCATCG T T C C A A G T A A T G G G A G T G T G T GneCcTG TTAAATAT A T G T T C A C G T A A A A A T G G TnCAAACGTCGGAACTATAGTA T T A A G G C C C G C C A G G TAACTTATT G A A A T A A T A C C T AeAuGGqAATCACACTTAATATAAACAGATTAGGG A G T A C T C A G A TAGTAGGTT G G T A G G G CeACCACATTTTAATGCGGGGTGATAATATTATATACAGGTAGAGAGGCTGGTTAACGCAGT C A G A TAAACGATCAGCT C AGAAA CS G G T T T A G G A T G C T C T T T C A T T T A AGGCGezislato)p3Tb2(41193OQNESDI3242P V PeMC MVmL _ 4 LC_aGA0 GA5NR R 0 R R00G G G C C T T C A T T T G C T C A G T G A C T T G G T G T C C CGGACTGCACCTTGAACTCG T T G C T A T G G C G T A A A C G A AG G G G T C A C T AGGCCCACTTCC C G T C C A A A T T A G G TG G A T T C C T T T G C T C TTGAATAGACCCGT T T T T A A A CT C T C T G A G T T C T G T G A A A G T TGATCATGTACG A G TG C C T A T G A T C A T GT C T ACC T C A T T C C C A T A A T A A TGCCGCCTCCCGA G T T A T G C A T A C G A T A A A A T A G T AC G G G T GTCGACACCTAAGT T G T A A A A G T T T T C T G G TG A C G G G A A C G G AAACAGATAAGT C T A G T T A A A C G TT C G G T C C G C C A T T A C C ATAGAAGTGACT A A A A C G AG G C G G C A C T C A A A A T A T G T A G ATCTGAAAATAA T AC C G A T A A A T C T G T C AA C TC T CT A G T A A T T T C A A G G CC C GAGTCCCGTGGA T T A G C T C A A T A C G A C C C A G T CT C T T G T A GCAAACCACTCC A G A G T A A A A A T G A T A GC C G C C T T A A T A G TTATTATTATAT A G A T G G G T C T TG G T T C T G C G T A G C C T T A CAAAAGTTTTTTTA G G G A AG T G A C A T A G C C G T A T T T G T A T T A GCCGGACTCGTGG G T G G A T C T G C G A C T ATG T G AG G T A A T T T C G T A G GC C T CGTCGGTACGAG C T A A A A A A T T A T A A T T G A A TG C G C C T A G CAGAAGCGGCATCT G G C T G T C T A T A A C AC T C A C T G A C G C G G A ACTGGCAAGAGG T C C G C A C T GC G T G T A G A C A C G T G C C T T T GAATTGTCTTCG C A T GCCT G A C C G T G C G G A A G G A G G T T T C T CTATCGATATACCGCGTTTCTTA G G C T T T G A A A A A A C T T A T C G G C AT T G G A CGAGAGGACCCC G G A A A A A C G T T G T A T T C TG G G C T G G G G T ATTTGTGCCATA G A T A C C G C T C A G AG T T G A A G T T C G T T G A TGAGAAATTTAC C G A G C C T TG C C C T C T T C G A T G T A T T A T T AGTCTTTTATTCAC T TC G A C T T T A T T G T A AC C GC TT T T G T C A T A T C G G T A CG GCACAGAACCCCTC A A A T G A A C T G A A G C G A T A G C GG G G A G A T TTTAGCATCACT A T T G A C T T A G A A T T A GG A G C C A T A G G A C CATACTATTTTAGG G C G A T A A A C TG G A C C G G A C G C G A G T T C A CTCTTTTTTTTA G T T C GT G C A C A G T G A A C G G A T C G A A A T A TAATTGGTTTCCG T G C C A G A G T G C T G T ACG G G AA T C T A C C T A T T A T TT T A CCGAATTTTTTAAT T G G T T T C G T G G A C A G T T T GG T C T G C T T A AACTTGTATAGC C A A A G T C T T A T C C CC T A C T G T A G T A T G A TATCCGGCTGTA G C T T T T T C AG C G C T A C T T A G T T A A T T A A TGTACGGAATAA C C G GC G G T C A T C T A A T CG A C T TGG G T A A C T A A A G T A T G C ACCGGGTGCAGAA T T G C C C T A A C A C T T C G C T A C G G GC G C T G AACCATAGTTGA G G G C C T T A T T A T A T T T G TC G C C T A T C C C GAGATGTAGCAA T A A C A C T G T T G G AnG A T T G G T A C G G T A T G TTTTGCTACTTA C C T T T A T Coit CCGAGCTGTCTTATCTCCGTTTCTGGTAAAAATTTTACCCTTCCTTTGTGTTGT A C G AATTTCGATTCatnGeGGiGCA G T A T T T T G C T T G A C A G C G G G A A T T G AGA CGCGATGGGTACGCTCAT C C G G G G G A G T T T T G A T A T C A T TCATCCTCT C G A T T G C A T T T C A T A T C C Gr G T G A T C T T T CCCAAATTAC C A A G T A A A T G A T C T Go3 C C A G T T G A C T G A T GGACTATTCT A A G G A A G A G T T'- C A G A C T A A G A A C T C T C T TCGAGAATGTAG A A G G T C5 C G A C C C A C A G G C C G T T C G A A A A AGTGTGTA T G G' G C A A C T A A A T G G G T G C T C C A T A T T T GAGGTTTTAniGeGGcGGATGT C C G G A T G A T G C T T C C A T A G T C G A G A GGGGAGTCGTTGA C A A C T G C T G A A T G G T A A T A C AnAeCCuGCATAGTCTCACATTCTTCCCGAGAC T A C G A G T T T A T C A C C C CCAGAGCACAA A G T G T G A G T T T A AqAGGTCGCCTCGTGAGTCTTATGGGATCAATGCCCCTTTCTTTT T A T A T A C T ATTTTTTAGATAT G G A CeCTTGCCTCACCGATCACGCACGAATCGCGATGAATTGCACTGT C C A T C A G C CGAAGAGAATGS G C AGTCTAACTTTTGCTGAGTGTAAAGTGATTCezislato)p7Tb9(73OQNESDI52PeMV LCm_aGA6NR R00C G T C T G C T C A G T A C A A G T G G G C G T T G T C A GATAAGTATACCACGGTTAA A A C A C G A G C T T T G T A A GG A T A G A C G A CGAATTTTGGAG A G A T A T A T A C A TA A T A T T G A G C T C C T AGTCATCAAGAA C G C T A G TA G G A A G T C C A T C C A A C C G A GAAGTAAATTTG G CG C T A T A A C A T T G TA C TA GT T T C T G T G T G T G G C GT TGTAGACGGCGC C C T A G T C G C C A A A T G T G T C CG G G A A T GGTCGTTCAAGT C C A G G G G T A C A A T C CT A A A C C A T A G A TCGCTCTCTCCA G A C C G C C T C GC G G G A G A G G T A C C G G G GCGATCCCAATA A T C A GG T A A C G C T T A G A A G A T A A C C C TCTTGATAGCCGT A A T A A T G A A T A G G TGT C G GC C C C A T C C A C T A AC G A GCACCGCTCTAG T C G A A C G G T G T G G T C C C TC A C G T C A A GATGTTCACAAA T G G T A C T G G C C C TG T A A A G G C G T C C T TTTCCAGGTTTG T T A G T G T TA T C A T T T T A G A A C G T A A G TTATTATCTTCA A C TA T A C A T A C A A G TC A C TAG C T C C T A C A C T A T T T AGGGTTTCTAGTC T T G G G A A T G A C A T A T T T C A T TG G G A T CCTGGCAGTTGT A T G A T T A T C A A G C G T TA T T A A T C G T T ATCCAAGTTGGG T T A T C A A C T A GA G G C T C C A A C C G C C A TTGGTACGACTC G C A G T GG A T A A T A C G T T A T T G T C T G C GGATGTGGTAGG AG T G T T T G A T C T G T GT AT A AT C G C T T A G A A C C C AG G GACATTTTGGAC A C A C T C C T C T C A A C A A T T GT A A T A T A GGTCATCTATAG T A A C C T C C C G A T T GG A A T T A A A G C C C TTATGCTGGGTT T T G T T A C C GG G G A A G C T A A A A C T T T A CCATATTGGTAA T G G CTGA G A T G T G A G G C G A G A C C T C G A ATGATTCTCTTTCGATTTATA C T A A G A T A A G G C A A T C T G T A T CC T T T ACAGGTTTTGTG A T A A G G C C G A T C A C T T TT A G T T G G T C CTTGGTGGCTCT T G A T A G T C T T C TC A T A A A T T T G A A T A TCGCCTTCAGTATA G C A G A GG G G T T G C T T T A A A C T G G G G T CAATTCGGTTCT GT G T G A A C T C A A C T AA AT G GT T A A T C A A G T C G G AC A AAATATTTCCAG A T C A G T A C G A G C T T G C T T AC A G G T T C AGTAGGAAAAGG C G G C A A T A C A C T T AT G A A A G A A T T A G TAAAAAGGATTT A A C C C A A T GA A A A T T G A C C T G C T A T C CCCAGAGGGCAA C C A TATG C A A A T A C A C T G T T T T C G A T G ACCGTCAAGTAGAATTTATAA T T A C T C T T A G G G T C T T T A C G T CG T T T TTGCCTTCCAGT C A T G A G A C A G C A T A T C AT A C C A T G T C ATATCACCCATC G G C A A G A T T C G GA T T T T A A A T A A T G A AACTTGGTTTTC G C C G A T AnT T C T A T T T C T C A A G G T G T C AATGCGGGGC C A Coit C T T T T A G T T T T C C A T T T C T G C T A TTCCTGGAAatGnGTeGGT T A A T T T T A A G C A C A C C T A C G G C C A GiTACAGCATATGTATATGAC T A T T A A G G T C G G A G G T G T G G ATTAACTTTCTCAGTA A G A T C C A G A C A C G C A T CAGGTGACG T A G G A C C T T T T T C Gr C A C T A T C A G A G A TATCGTGTTA A C C C T G C T T Ao3 T A T T G A G A T C A A G C G T GGAGTTTATT T T C C G G'- C T G A A T A T C A T G T G T C T T G G GGTTCATCGC T G'5 TGG T T C A T C C T T A T G G T G A G T G C A A ACTAAAAATGGCA A T A G T A T T C A C T T A A T T C G T C C C GnieGcAAAAAAGTGTAATAATG C G G C A G C C A A A T C A T G A C A GATAAAACACT G G T T A T C G C T G T C T A AnGeAAuCACTATTGTAGTCAGTCCAGCTTGGGGTGCAT A T A T G A G C G G G GCAGCGAGCGT T A A C G A G AqTTATTTGACTTACCATCCGAAGTAGATTAACGAGCAAGACTTACTGAAG A G G CTGAGTTATGCeTGT G G G T G C T A G T G G A T T T A C G G T G G G GGAS ATTCGGATCTAGTCAGGCTATGTGTTCTATATTTGTTACAAAATTTGGTGAGAGCAezislato)p94Tb(13OQNESDI62PeMV LCm_aGA7NR R00T G A A T A C T A T T T T A A T C G G A T A G T A A G A T A A TGTAGACTTGTGGATCATGG C T A C C T G G A T A A A C G A A T AA A T A G T T A A GTATATCAGAGC T G A A G G A T T G A G T CC G A G A A C T G A A C T T AGTTAACTCTGT A C T G A A A A AA A T G C T G A A C A A C G G A G A G AAATGAATTACC G G T TCCG T G C A T T T C T C G A T A G A C A G T A A CGGGGACTTGACAGCCCCCGC G G G G A A T C A A A A A G T T A T A T G G A TT T T T GTCAATATTGGT T T G A G A A A T A A G G T T A T C GT A T G T A A T T CTTTTTAATTAA A C G A A T A T A G T A C TA G G T G A G A C G T T G C TCTTCTAACATT T G A A A G A G GA A T T A A T T G T G A A T C G T T T TCGTGGTTTGTG T C A TGTA C T A T C A A C G T T A T T C A T A G T C T CGTATGACGCTGAGTCGGGAT T G A C T T G A T A A G C G A C C A C G A C G GT T C A CGGTTAGCCTCA C T A T C G T A C T C A T T T C A A TA C G C T A T T A CTAACCTAGACT G G A A C A A C T G C G T CG C G C C A C T G T T A G T TAAAATATTGGT T C T T G C G G GA C G T T G C T A G G G T T C A T A A TAAAAACACTAC C G T TAAA A C C G G C A A T T C C C A T A A A A A T G CCTTTTCGTTTTATCTTAAGT T A G G A A C A C A A A A T G G G A C C T T G TT T G T TACAATAATTCT A T C T G T T A A A A A A C C T G T AG T T C T T T A T GCGTTGAGGTGG A T C A T A A G A C G G C TT T C C T C G T T G T A A A AACGGTTGAGGT T A A T T A T T TC A T C C C A T T C A C A C A G T A G ACAGCAATCTAT G C C TCCC A A C G T T C C T G C T C A C G T T A G A T TAGACTCTAATGTTCTGTTCA G T T C A G C T A A A G T T T T T G T T T T C AT T T G CCGGGTAAAGAT A A G A G A A A A A T T A T T A T G AC C C G A G A G A CTACCTTTAGAG T T C C A A A T C C A G T GC C A G C A T A T C T G G T TGAGCGATTCTA A T A A G T T T AC G C G G C A G A A G G A C A T G C C CAGTAAATCGAA T T C ACGG T T A A C T C C T G C T A G T C G C A A A G ACCGTAAGTATGGGGAGGTAC A G T C T T C T G G C T C C A A T T A C A G A TA G A A AATTGAATAGGT A A T T T T T G C A T T A T T T A A AC G C G A A T G A GTGTAGGATTGT A T A C C T T T G A A T G AG T G A T C T T T G G A T T TCATGCCTGTTG T T T T A C T T AA C G C A A T G T T T T C T A A G C A TGGATTGTCAGA G C A TCAG G T T G A G T G T T T A C G T A A T A G A A AGGTTATAATCCTGTTTTTAG A T T T T G A A T A C T G T A T A C C A A T T AA A C A AAGTGTACTCGT T G G A A A G T T G A G T C G T C C AG A C A G T A C A GCAAGAAAAAAT A T T T G T A C T G T C T GA A A T G C A A A G T T A T TTTTGCTCTGCG A T G C A T T T TT A G G A T C A G A A T T A A C T G G TATGATAATGGG T T A GTTG T A G T C A T G T T T T G C C A A G C A A C TGTTGGTCTGTAACGGGGACG C G C G T A T T T G G C A A A A A A A T T C T AnT T C T CTCCCGTTTT G A A A G G T G A A A T A T A C C G T Toit TTCCCGCGCTCCTTAAACAATGCCAATGTA T A T G A T C T T C A T T G G GCAAGTGGA G A T A T T C G C C G T AatnAeAGAATGTGTTCTTAATGTGGTATCAGTCATTACATTAAAGTAG G T G T A T T C CAACTTTATGC A T G G GiGGTGGAGGTTTGTTATATTCTGTTAAC T C T G G C A A C ATGGACGTCAGATrT T C G G T C T T A G G A A A A GoG3 GGGCAAAT G T T C C G C T T T A A A C T T T T C T G C G G A'- C T C CCGTTTTTCT C G A T T A C G T G A A A T C A G C T A T5 C C G C G T C AGAGAGCC G T T T T C A G C A A G T G C C C A' TiTTTACACTGCAAGAGTAGTAAATATGCATGGTG G C A G T G T T C G G C A AATCGCTGGTT A T A T G T T A T AneC G G A T A T G T G A C A T A G A A GTACACCAAT T C A T T AcGnTTAAGGTTTACGATCATAAGTATGTATACGGGTCGTAGGGCTCGTGAACTCACAGAG A GGTCTGTCeCuAAqGGGGACGAG A A T A A C A A G A A G T A T C T A A A A G G T CAACTCCCTTC G T T A A G T T C G C G C T T T G T A G CeAAGTTGGTCCAGCAGTTCTTGCCCTCTA C T G G T T G A G T G C G T T G TAACAGGGG T T T T T T T T T A A A T GS C C T A T A C C A C G C G T TACAGATTATACGATATGTCACGCATCATGGezislato)pTb(OQNESDIemaNC C C T A A C C G T T A A G T T G G G A A G C A T C C C TCGTCAACTTCATCGCCCGACCGC A G T T T T C C G T A A T TA T G G G C T C T A C ACATTTTTTACTCG C C A T G G T AC C A G A G C C G A G A T G A A T CAGTTAAGTCTAAT T AT T T A A G G T T C G T AG G TT G AA G A G T T C G A C A A A AA G CAATCGTTTTTCAC T C C T T A A T T G T T C G A T AA G G C G T A C CACTCACGTGCTAA A C G T G C T A A G CG T A T G T T A A A A A T G ATTACAAGCCAATTCT T T A TT T A C T C C C G G CC T T C CTG G T T T T G A T G T C T A C TCGAGACTGACTTAC T A G A T C A T T A G T T C A A T T CG C G G T T CCTCTCTCCTCCGG G T T G A G C A G T C T CA A T A C G C C T T A A ATCTCAATAATACT T T T A A T TT A T A G C G C A C C C G G C A T C TAGCGCCTTATCAG CT C T A A G A T G C C A T GG TT G T GT T A T T A C A C C A T TT A A ACTTAGACTTTCCG C C G A T G A T G A C G T G G CC G T C T C C G T CAGCTAGAACAAGGGG T T G C G T A T TT T T C A T G G A C T T G G A G T AGTTGTGAGGGC T A C TTTC G A C T G T T G C G T T A G T G G C G T AAGTCAAGATCTAAAATTAAT G G G T T T T C T A T G T A T T T A A G G TC A C C CCGACTGTGCAT G C G A C C T T A T A T G T G A CG A A A A A T T A GCGGAAGTTAGC A T C A A G G A T T C CT T A T C T G G C A T C T A ATTTTTAGGTCC G G G C G A GG C G T A A A T C A T A C G G C C G T TTCGGCAGTCTA A GT C G G C A A A T C T T G GA T CG G GA A C A G C G G G T C G T CA T AGTCCCCAAAAC T A T A G C G T A A T A G A T C T T GC C A A C A T CATCCCAAGGTA G G A G G C C T C C G G G GT G C T A C A C G C T G ATTGGTAATTTT A G C A A A T A TA T C A G G C A T T T G G T T A A AATCAGGGGCTT G T C TCTC T A T G G G G G C T A T G A C C G A G T CTTACTAGAGTAGTCGTTGTA G T G A G C G T C C A A A C T C C A C A C GA C G C GCCGTGTGTCTT G A T T T T A C C C G C C T G A AG G A C G A C C C CTATGGATGTACCT C C G T T G G T G A TA T C G A G G T G G T A C T G GTAGGACTATAT T T T G G GG C C A C T G T A G C A A G A G C T T G GCCTTTACGTTA GG G C G G A G C C G T A C TT AA T AG A T T G A T G T A A A T CG A TGGGAAACTAGC A A C C C A A C C A T G G T A C A T AA A T T G C C AACGTCCTCAAC C T A A T G G G C G G A T TG A A T G T G A A T G T AGGGATACATGT T T T A G T C T AT T A G G C A G T G A C C A A C C AGGAACGTTGGC A G A GT A T T G G T A G G G CA T G C TGA A C A A G T T T T A A A T G GGACGCTTGTAAT C T A A G A T C A A T G T C C C A C T A CG A A G C GTTCCCTCACGG G T A G T C A T G C G A A C G Tni T T C T C T T A A C GCTGGTAGAA T T G T T A T T G T G Aot A G G C G T T A A C G C A G GGTAGATTCA T T T G C A T CtG A T G A C T C C C A C G A G A G G GGTGGGTA G A A A CanG A T G C T T T G T C G G C T T G T T T A AGAGATTTGA AeCiCA C A C A T G G A T C G T T T T G G C A T C A T GATAGGGGTAATGTA T A A G G C G T C G T G T T T G G T T A A Ar T A C G GAATTCACGG A C G G C A C A T T G T C T T G A Co T G A T T G T A ACCAAACTTG A A C A G T T A A C A A A T'3- GATACCAGTTATTTCAACACATCTCGTAGCGTAGTTAA C C A G C T G T A TAGTTTAGA T C T T T A G'5CCAGGAACGATCTTTCCCAGAACAGTTCGCAATAATGTTAATTGTTTGCTGCG A G TCACGCATGnieCcCA G T T G T C A C T G T A A A T C A G G T C T T T C AGGnTGAACAAGCG T T C A A G G C A T A G T A T A T C C G A A AeTuCAqGGACCTATCCTCTTCCA T G G C G G C A A A C G C T T C A A A GGCTGTTGT T T C T T A G T A A G T G T A T AeTACATTGATGCGTTCCCGATTTCTTCTCGCCTGCTGCAGAAA A C C G T T A A G A T G G GGTCATTGTCGGATCT A T G C T G T G T CGGTTTA T G A A C A C AS G C C A T G C A C A T C A C G T A A G ATACTCGTGCGACCCGGCAezislato)p 25Tb(79281OQNESDI7282PeMV P Vma LCG_MA8 LCG_A9NR R00 R R00T A A C G T A C G A A T T T T G G A A G A T T A A C G G A TTAAAAGTTTCCCACTGGAAATAT C T A A T A A A G T C T T G AA T G T C T A T T T G T ATTCTTTCCCCA T C T G T G T C T GT A G A G C G C C G G A T T A G G GAATGCTTTGTT T G A C GA T G C G C A G T G C A A T A T T T A T G G ATTCGCAAGCAGT A T C G A C T T A G A C T A CTA T C GG C A T A T T A T C C C TT A T AGTGACCCCCGT G A A T A C T G G T T T T C T A T A TA T A G C C C G TCGAGATGATTG G A A G A G T G A C C C C CT G T T G G A G T A G A T TTTACGTCGTCA T A G A G G T T AA T A C A A C A T C G A T T T G T A GTGAGAATCGTG G G A CTAA T T T A G C A T C A C C A A T C A A G C A TTTACGTCTGATTAGTTGGTC A T C A T A G T G A G C A T A G C T C A C G CA T A A CCACGTCATAAC A A T A G A G G C C T T T T T G A CT A T G G G A T T AAAACAACTCTA C A A C C C A A A C G G CA T G C C T C T C A G T T T GTTCCTTAACGT A T C G A A T TT G T T C T T G G C T C C C A C C C A TAGTATGACTAGGC G AA C A T G A C T T A T T A TT T AT AT A T G T T A T G A T G G G TA TTAAATCAGGCA T T C G G T T G C T T T G C A A G T G G GT A T C A G ACAATAAACCCT C A T A A G A T A T C A C T A TA T A A C T A T C A T TCCCCTCCTTCC A G T G C G T G T C CT A T T C T G C T A A C A T A G CGTACAATCATT A G A G A CA T A A A C A G A A A A G A A A C T C G C ATGAAACTGTAT GT A T A G G G A C T G G A A AT TA T AT C T G C A G A T G A C A AT G TAGGGGAACAACGC A A T A G G T T A C C T T C T G C G CA T A A G A A A AATGGACTTAAA T G A A G T A C T G T A G TT A T C C G A T G C G G G AGGCTTGCAGGA G A A C A T T G CA T G T T G C T A T C A T C A T T G TCTATCTAACTG C T T GTGA T G C G T T C C G A C C A T G G G T A T T CGTTCTTCGGTTTAGTAGTAG T G G T G G T T A C T G A T T T A T C C G T GC T G A CTTCAGAGGGCA G T A G T T G A T A T G C A G G G GA G T C C G A T A CGTTCTTAATTG T A C A A T A C G A G A TG T G T C T C G C C T C C T CTTGTGTACCCGTT G C A G G A AT A T G C G G G T C G G T G T T C A G T TATCCACCCTCC A CA T G T G A T T G A G A A TA C GA AT C C G G G G T C C C C G C GA TCAGGTAGTATT A A T C T C C A C G G G G A A C A G A C GC A T T C A AAAAAAAGGCTG A C C A G A T G T C A C T G T TA T A A C G G T A C G CAGTTTCAGAAT T A A T T C T C A C CG A T C T T T A T G A A A A C G CGTAATACGGTT T G C T C AT T A G C G A T A G T C T T A T A T A T G TGTATTCCTGAG GA G T T C C A T C T C G T T CA AC T A TA C G G A A A T A T T T C TT A T ATGTGAGCTGGA A T C T T T A T G A A T G A C C T T TA T A A T G G G GCATCCAGGAAG T A C A T A T T C A A T C TG A T T C A A T T A G C T ATCTTGTGACGT C G C A C T T C AnT T A A C C A C C C A C A A G T T C GCACTGAAAC T C T G Toit CtGATTAAAGTGTAGGTGGCGTCGTGGT T A C G T C T G AATCTGAATTCTAa G A C T A T T C G A C G A G C CnAeAAiACTTAGCCTAC A G A G G C A T G A T A C T G C A T G A C T C AGGTGCGGGAAGATCCATT T C G G A A C C T T C T T T G T T G ACCTTATAA A T A T C G A T G C C A T T T Ar A A C A A C C G G G T GAACTTAAAT G G G A T G T C T T C Co3 C C A A G A C A A A G A T C A GTTAATCATG T A T A G T T T'- TTACTAGTCCCCCTCATCCCTCGTAATCGTGAGACTTATTTGCTGTTGTACG G A A TTAGTCATG C'5TAA T G A C C G T A C C A G T C A C A C C A T T T C CTGTTnieTCcCAACTTAAGGGC G T T G A G T G C C G T T A A T T C T T G A ATACACCCTTAAC A A A C C T T C A G A A T T C A A CnAeAAuGCTAGACGCCTCACGATGTGGATAGATATT A T G T T G A A C T C C C ATGGCTGGTTT A T G T T T G C T AqTACTGCTGATGTGTTGTTGCGGCATGATTATATTTCAACGCAAGGTT C T C C C GTTATTTTCTA C TeT A T A C T T T C A G G A T T T A A A C T C G C T CCAAGTTSTTTAACGGGTTCAGTTCCGGTGTTAATGTTTCGTCGAAAAATGTTTCCTTCACCTCCCezislato)p8Tb6(12OQNESDI92PeMV LCm_aGA0NR R10A A G T A T C G G A A T T A T T C G T G A C G C G A C T CCTTCTTAAAATATGCTCAACGTTTG T C T G G A A A A A T G AT A G T A C C A C T A A CACCATACCTTGTCTA A C T T A TCTG A A C C C A G C A A C G G C T G C ACGGTTCCAGTAGACAGAGATATTTATTC A A G T C G A C T A G C T T A T C A GC G C C T T TTGGAGTAAAAGTTTT T C A T A A C G T G A GC G A G G A C T C A A A C GTTAGAGTGCCCAT A G A C T T TC A G A G A T G G G C A G T A T T T C CCTAAGTGCCCGCG AC C T A G G T G T A C T T A GC CA G G CC C T T G T A A G A A T CG G G GAAGTCTAATTAAT T A C T C C T C G C T A A C C G TA A G A A T T T C TTTATCCATCGCGT A G A G C G G C T G CA G T A A G G G T T C T T G G TACCTGTCCTTTTA A C T T CCGT C C T G A T T T C C C T T C C C A A T CGGCAGGACAGGTACGCGGTGAACC G T A A A C C T T G A T G A T A G A C G CT G A C A TCTCATGTCAACTC A G A G T G A C C C C A G T CA G C G A T T A G T A ATCTCACGATCTTA G A C G G C C A GC G C T C C T G T A G A A T T C A TTAAGTTGTGAGGG T C AA G T C A T G A T C A A GA C G CA AA T G A T C A C C A T A G G CC TCTTTTCTAGGA T T G A A C A T G T C T T G C C C A A T CG T T A T A TCCGTCTAGACA A A A T T T T T T C G C A G G CG C G T T A T C G T T CTTCAAAAGATT C C T T A G G T T T CG A T C T A T T C C G G T C C T TTATTCTAGATA A A G C G GT T C T T A T T C G G T C T C C A G C G T CAGGGCCGGGTC TC C A A C C C A A T A T T T TT CC G CC G T G T G T T A T A G C CG A CCTTAGGTTGAA T T A C C A T G G A G T A G C C A T A TA C A T T A G TATTAGATTTTA T G A T C T C C G T C T G C CC C C A C A C G C C C A AGTGTTTAGCTC A G C A C C T G T CC C A T T G T T G A T T A A T T G CAACGTTGACGA G C T C AA T C T A G A T T T A G G A C A G C T A A G GTCTCAGCGCATG G T T A T A C G T T G T A T GTA A A AT A C A C A T G A A T G CG T G TTTAAAACGTCC T T G A A T C C T A T C G A C A G T GT A T T T A T A CGTGTACAGAAC A A C C A C G G C C A G C TT T A G A T C C A T G A G GTATCGTGAA G C G T C A T G G TT C C T A T A C G A T A A A A G G CGGTCCTGAGCC C G C T CG C C C T T T C G T A G A A A G T G G T T C GTAGGTGCGACCA G G A T T T C T C C A A G G GCG T A CG G A A G T G A T T T G TG A G ACTTCTAGAAGT T A A A A G A T C G T G A T A G C T AA C T A A T A C CACTTCGAAGAC T A C C A G A T G G G C T TT G G A C G A G C C C G A ACTGAGACCTCC A A C T A T T T TC T A A A T A A T G G G T T T C G G AGTTTAAGACCG A T T GTGG C C C G G A A A T T C A A C G A T C G T T GCCAGTGCCATACTGTAAGAG G C A G A C T A T C T G A C G A T C A A C C Tni G G C A ATGTGCCAGA T G T A G T T C A C G C A A A A A G Tot T G G A T T A G TCGCCGTGCA T A T A G T T G A G G A C A TtT T G C A A A A C G T T CCAGAAAC A T C C G A A T G A C TanCeGG A A A A A A T G A C T A G ACAGCCTTCT G A C G A T C CiTTTGGGTATAAAGAATTACGTAATGAGCCTCACATGTATGATTTCCTTGCAATGTTGCAGCGAGA A C T CTCGAAACCAACr AC G A T A A A G T G T G C G Co GATGGCCACT C C G G T T T T G A G G C C A G A G T A G G A'3- GACGAGTCGGAGTAATTCACAA A T A C A A G G G C A C A T G A A T CGAATATCT G C T T A A A G T A G G A T G C'5GAATGGTGGTCATTTAGAATTAGTCGAAACCTAGTA C C A T C A T A A G C TAAGTACGACC G A G G G A G TnieAcCTATCTCGTTACTCGGTACTTTTGGCACTCAAGATATCTGTAAATCCGTGG A C G CCCGAAGTGTGnGeGAuAAC C T G G T G G G G T C T A A A T G G T T C G A C TGTqGAGACATAAAA C T G T A C C C G T C G G T G G G A A T T CeTACAGATGTTTAAGGCTATGGTCAATGAGTG A C A T T C T C T T A T A G A T G CCCGGTGTAGCTTCAC C A T C A T T C T G C T T TTATTCGGC A C A A T T A T A G GS G A G G G G A A T G G T T T C A TTGATTACCAAGTAACCTTCATCTGezislato)p 9Tb(60836OQNESDI0313PeMV P Vma LCG_MA1 LCG_A2NR R10 R R10G G T A C A T A T A A C A G C G A T G A T A T C C A A T CGGTGGATGCGTCAACCAGAATATTA T G C C T T C C A C T T AG T T A T G C T C G A A ACCCTACAGCCTCT A T A C A G TG C T A A G G T G G C G A C G T T G CTGAAAGAAAACCGTTG C T C C T T T G T G C A A CTC A C A TG C A C T A T A G T T CT G A C CCGCCCTCCATAAGGA A C C A G T A T C A T C T TC T C C C G G T C C C GAAGTTCAGAGTGT A T G A G A A GG T C C C G G T C G C C C G A A A TTTGATTGGAATGGAG TA T A T C C A G A A A G G TG AG G A GG G A G C T G T C G A T GA C T TGGTCAATTCGAAAAG T G G A G A C G C G A T C A AT G G G T G G C A G AAGAAGTGCAGGGT T T A G T A G A AG G T A T A A C C A T T A A G A TGTGGCTTTAGAAAGA A GG A C C C C G T G C A C AG A TA A CA A C A G A A A T A A A G CA A CATCGACAGCTACCCC G A G G G T T C C T C A G C A CT T G G G T G T C GAAGATCAGACTGT C T A A G A G A A TT C G G T C G A T G C G A G A TTTTCTCTATAGATCA G T CT C T G A T G G A G T GC C T CT GT A G G G G T G A G A G G T GA ATTGTCTACAGGGCCG A G C C C C G C T T C G T G G C AT T T C C C A A ATTAATTTCGGGGA T C T C T G C A G G CA C A A C C G C T A G T T A GCTTTCTCGACTTTTT G T A GA T C C T A A G C T TA T C A AAC G G T C G T A T A T T C C T AG TTCTACGCCTCCAT C A C A C T C C C G G A T C G G G T GT C C T T C G CGTTGAGCTCGC C C G G A T A T A C G A C TA T T A C T A C C T G G ACCGGGATCTACTC T T C C A C A TA T C A G G A T T A T T C A A C A C CTTATAAGACCG C A TG C C G A C C T T C T C CG T G TAC A G C C T T T T A C A A C C TAGTCGTGCCT A C A A C T C C A G T G T T G A A C A C A A GT T A T TCTTTTTGGCGC G G T G G C G T G T C A C A T C A TT T A G A C G C G GCTAAATAAT C A G C T G C T C G C G A CG A G T A T T G T A A T A TGGTCCGTGACA C A A A T A T A AG C G T G T C T C G A A T G C G T A TAGCGCCATATG T C G GAAA G G T T G T C G G A A T A T C A T T T C A GGCCAACAAGTATTCAATT C T T C T A A A C C C A A T G A C A T A A C A CT C C TCTTCCCACCGC T G G C A G C A G A C T A C C C G A CC G C T T C C A AGCGGAGACG A A C A T G C T T C A C G A TC T G T C G T T G A T T GCATCCCGCACC G T T T G A C A A AT T C T A A T T G C G A A C G C G AGTCACCCCA C T T C A AA A G C T C G C G C T G A T G T C A G C G TAAACCGGATAA TT T G T G A T G C A T A G CA CG CT G T A A G A C A T G T G A TG TTCAATAAGCTT C A A A A G C A A A A G G A A C T G A A GT A C G C T TTACTGGGAC A G C T G T T T A T C G C T G G TC C T T T A C T C G TGACGTGTAGTA A C T A C T G C C C A Tni A C C T A G T C C A T C T G C CGCAACCT G C T T T C C A Got T G C C C C G T T G C C G C C C C A CAGAGTTCAG A A G A AtT A C T C T T A G A T T G G A G G C T G G T AACCCC A G AanT G G T A C G C C C T T A C G T A A A T G A T A AGGGTAAACeGiAAGCA C A G T C C G G C C G A G G A C C A T G C G G G A TGACAGCCC A G T C G G C G G G T A T G C T G G A C A A Tr A G C T CAACTAGC A T C G G C G G A A G T T T G A G C A To A G G T T A A ACCAATTCTG C T C A C T A C T A G C G G A T'3- GTACCGACCTGGGACGGTTCTACAGCCCGAGGG C A T T C A A T T T T A CAGTGTAAT C C C T C A G T A A'5GTTGAAGGTTATTCGGAGAGGAACCATCGGGGTCACAGCTGGATA A G G G C A GCACCAGTAGT A A GnieAcCA C A T T T A A T C G C A A T G A T G G A C C GACAGAAGnGAAG G C T A C C C A G T C C C A C T T G G T T A G G AGAeAuTAAqGTTGGAAGTC C T G C A A C G T C G A C T C A G T C G C A GACAGAGATGT A C C G G G G A A T G A T G T A G A GeGAGCAGGGTAACTGTACCCAAATTAATGTCAACTCG G G G C A C A T A C C G C G A AGGGACAGGAAGGTCG A C C G T C A G C A A TCGAAAC A G A G C A G G A GS A G G T C G C T G G T C G C A G G ACAGCGGATAGCGGCATGGCTGGezislato)p 79Tb(07442OQNESDI2333PeMV P Vma LCG_MA3 LCG_A4NR R10 R R10C C A G T G C T A C A A T G T T G T G T A C T C C T ATACGGGCAAAGTTACCGTCCGAACA T G A A C T A T G T GT A A T C A T C G C G A T TAGTATGTACGGTT A A G C TTGT C T G G C C G G T T C T G C A G T GAATAATTAATCATGTACCATCACC C A G T T T A T A C A T T C C G C C CT C A T A ACGCGGTTGACACT T G T A C C A G G T A G CC C A C C C T G G T A GCGGGAATCACGAC T T G C A A GA A C G C G T C G C G G T T A G G CGGGTATGTCACGC TA T G A C T T T T A G C T CC AA A G CA T G G T G C C C G C CC T T CCCGTTATGGACTG G T A G T A G T T A G A G T CT T C C A G C A C GATTCACCTTAATA A C G A G T T C AT C C T C G T C C A A C A A C CAAAGGTTGAGGCT C A GA G G G T T A T C C C GC C T TG GT A A T A A G T A T G G A GG TACATAGGAAACGA C T A T A A A A C C G A C G A C CA G C G T C G GTCCCCAGTCGTTA C C T T T G G T C C CC A A T A T A G T T C T T AAGCGAATTTAGTA A G C C AA C G C T T G A C C T A T A A A T A C GAACGGCAGGTAT G A C G C T A A C T A A T AGG T G G CG C G G T G T A A A TT G C T AGTGAGGTACTCCA T T A A T T G G A G T G T GT G T A A T T T G T ATACTTCTCCGTCC T T C T G C A AT G T C T A T G T C G A A T T G CACCCGTTCTTGAT C CT T G A A A T A C T C A CT G GG T AC C G T G T G A C C G A GA G GCGATAAAGATCAC C G C G C A A G T T G A C A T TA G G G G A G C GAGTTGGGAAAAAC C T A G T G G G G GT A A T T A A T G T C G G G GTGATTACCTGGTT G G G GT T C G C A A C T C TC T A T AAA A A G A C C G T A C G C A AGTTCAATGGAATGT C G G A C T A A A A T G G C A T C CT C G G A A AGTTTGATAGGGGA A A C A A C G A C T G TG G A T G A A C A C G A GATAGATCTCACAG T G G G G GG T G G T A A T C G T A A T T A G T GTTGGTATCTCG G GA T T G C A A T C C G A CG T AA TT G C A G A C T A T C T C GA ATCGCTGAAGGT G G A A T T A G G T C A T C T A T G GA A G C A A ACCTGGTGAG G C T G G T A T G T C A C A GA G T G G C A A G G GAAAATACCGTA T A G G A G A G T AG A C A A T C A T T A C A A G CCGTAAGTTATG T A T T CT A A G A C G G A A C C A A T G A T G T CGATTTATAAGCA T G A T T G A C A T T T G TCA T G AG T G A A T A A G G A GG G A ACCGTTCCTTGC G C A T G G T T G T T T C A G A AT A T A G C T G AACGATCCGACG C T G A G A C A T T A GC T G G A C A A A A C C G AACTCCGGCCAT C C T A G A TT C G T G C G G A G C G G G A G T C CGAATTCTCTTG A TA T A T T A G T T G T G TG C CnTT A A C G G G T T G T T G Goit ATTCGGGTATTTCG T A A A C G C T A G T T A A T T T T T T TAAAAGGAG A C G G G G G T A C A T C T T G A TatnTeTAAGTAACTCGATTATTCTCTGGGTTG T T T C T C C G C A G A A ACGCTCACTGC T C A T A T G G A GiAGTTCGAAAGAAACACGTAACATCTCACGGATATTTTGTCGGGC T C A T A GGCCGGTAC C A Ar T G G A G A G G A G G T G C T G A A C A C T CTTGGCAGo3 T G A A A C T G T G G C A GG'- C5 TGG G G C G A A C C G A T GTGGTCGGA A T C G A G T A T G A C G G G A G T G G T' T C G T AGTAGGAGCA C T C A C T C A T A C A A G G T GiG A T C C A A T CTCACAATTG T A A A A T T A G A G C GneGcTT T T A G T C C T C T GTTCTAAGTA A A T A A T T T GnAGGTCACGAGTGGTCTATCCGAAGCATTTGGTAAACTATATGTGT C A T A GTATGGACTCC GeCuCA A C A T A A A C G A A G G G T C A C T C T G A ATTTGqTGGTGT T C C C A C T G A A T A C G A A T A G A C C C GeTCTCTCTACGCGGAC T G G C A C A G G T T A C G T T C C G A ACCCGTA T C T A G T A T C T A A C A T A A A GS A C C A A C A TCTGATATCGATGGTAACGTGGTCAGTGCGAGAGACCAGGGezislato)p 5326 3Tb( 27471OQNESDI435363P P PeMV CMV MVma L _A5 LC_A6 LC_A7NGRR10GRR10GRR10G C T T A A A G G A A A T G C C A A C C T A A T T G T C T ATTTCATCGTCCTCATTAATTC C A T T G G G G G T G T C A C AC A A T C G C C C T CGAGACGATTCAAA A G T C A G T C T TA T A T A A T G T A A T T T G A GAAATGAAATATTG C G T CTTA A T T T G G G C G T C C A T A G C T A A TACCCGTTCTGTAAATTCACGTC A G T G G T T A G T G C C C A C C C T T TT A A A A TTCCATCTTTCTGA A A A T T C G C T A A T T C GT T A G C A T T G A T TATAATTGGCGGTA T A A C A C T G TT A A A A A A T G T A A C T T A A ATGTGTTATATA A A C TA C A A T A A A A A A AA A A T CAG C T A C C T G C T C A A A G AGACACAGTTATCGG C T T A G T T C A C C T T C G G C A T CG G C G T T TGGCGACTTACACT T A T G G C T T T A T A C TG A G T T C G T G A T T ATTATAACATCACC G C G A G T C GC A A C A A G G T T A C G G T T C A TAAGAGGGTTAACT C AG A T A G A C G T C C C T AT T TT C TA T C C C G A A A G A A G GC T ACAAATAGTAGGTG T T C C T A A A G A G G C A C T G TC A T T C A G G GATACTAAAT T G C A A T T C G A C A G G CA T A A A G A A C T A T TTTTTGTGGCCT C T T A A G T T A AA T C A T T G A T A A C T T A T T CGATTAAGATTC T A A T AA T T A A A G C A G C A T T C A A C C C G G ACGTTAGCACTCA A T T G C T C C G A T T T G TTA T A TG A A G G G T T T A C A CA A A CTTTTTGCTTTG C A T A A A A C T T G T T A A C A C CC C T C T C G C TTCGAATTTCCA T G T T T G C C C C G A T AA A C T A T A T G G T T T TAATAGACGGTT T A T T A G A C TA A T T A T C G G T T T T T T G G G CACCTATGTC C A T C GA A T T G T C A G G A T T C A T T T T A G C GTTGTGACTACTA A C C T C C C G A T G T T T CCA C T TC C C T G T T T A A T A TA T A CCTCTGTTCTAA A G T G A C T G T T T T G A T T G G CC C T A T C T C GACTTTGTTTAA T G T G C G A T C C A A T CT T G C T C G G A C A A T GTATCGACCGGG T A A A G A A C GC T G A A T T T G C A C T G G T T C ATTAACATAGAT T A T ATGG T T T A C A A T T T T G T C G C C A G G C GTGCAACAGCATAAGACTT C T C T C T T T G A A G G T T A T G T T A A G CT A A GAAGACTTCGAC T T T G C A T G C C G T T T G C C T GC G A A G T C T CGGGATTTTTAA C T T A T G A G A G A A C AG A T C G T T T T C A A T CCCCCCACGTCA A G T T A C T T TA A T G T T C A C T A T T A G C C A TCCAGATGTTCT A G A CAAC C A A T T G T C A T T T A C T T C G T C G AGGAATAATGTGATTCTGATT G C T C G T G C A T G A A A G T T C A G A T TT A T T ACTAGGAATGTT A A G T T G A C G T A G C G G A T TG T A T T C G A C CGATTCTGAT T T G C A A C T G T A C T TA T C T G A T C T C T A G TAAAAGAGAGAC A C G G T A T A TG C T A G C G T T G A C A T T C T G AGGCACCTGTAT C G T AnG T T A T C A T T T C G A A A A T T T G G T T ATACCTTAACoit CtAG T T A A A G T C A T G A T A A G T A C G G G C G T ATCanGTeTGATTAATT T G T T T T T T A G A T T C C T T A A A T A GiGCGGTGTATCCACAATAGTGATTATCAA T G A G A T T C C T C T G A A T C C TCTGCTCAATGTAGAG A A G A T G A G T T C C T C CATCAGA T G T A G A G A G T T T Tr G T A G A A T T G A A A T A TAGGGGTGTA A G T A A T C T To3 T T G G A A T C G A C A A G A T A T AAAAGTAACG C T A C T'- C T T A C A T T T C A A C A G T C A T T G A AAACTGAATC T5 CGA T C A C T G A T G A TC G'C T A G T G A G T T A T A C T GTGACTCAA C C T C C A T A A T T A C T C A A T A C C T G GnieCcCTTAATCACTTTCTTCTTA C A A A G T G C C T G G A A T T T T A TCCCAGAGTTT A T T A T C G G A A T T T C T GnGeATuCTCACAGTTGTACACCTCAGTTTTTTTGTAA A T A G G A A T A G A G TAGAAAGAACT C G T T G A A A CqCATTTTCATTATAACACCTTACGATGTACAAAGCACCAGCGATTGCCGG T A G A TATATCAAGTA TeT T A A G C T G C T A T T T C C A C A G A C T A C A CATCASCATAACTTATGTACTAACAAATCACGAATCGAGAAAAGCTTCTATGTAACCCCGAATCezislato)p69Tb(21OQNESDI73PeMV LCm_aGA8NR R10T T T C A A A G T G G T A G T A A G T C G C C A A G G T C CGTGAATCTGAAAACGTATCTA C A C C A A A A T A T C G A A AG G A A T G G C T C TAAGAACTGCCACA C C T C C A A G C TG T A C A A T T A A T T A C T G AAATCTACGCTTAT C C G TT A T G A T T T A C C AC C G G CCG A T A G T C C G T G A C T G GCACATTCCGCGGTC T C T T T A T G T A G T T C C G G G C AC T C G T A CACGTACAAAACTT A A C T T T G T T G T G C CC T G T A C G T G T T A GACACATAATCCCT A T C G T A C AG T T A G G G T A A G T G T G T C G GACCGCTGGTCG C C GT T T T A T A T C T A T AT A C AA TA T C G G T C C C T G A T G GT TTCTATAGTACCGC C G G C T C C A G T A T G G A C T A AG T G A C G A ATACCAAAGTTTAC C A G T T G A A T T A G GG T C A C A G C A G A G T TACGATGAATGGGG A C G A G A AT T C T T A G A A T A C C G G C C T G TTCGAATAGCTGGC GT A G A T A G A C C G T C A AC AG G T CT C A T C T G G T T T G GG T T TTCTAAGTTTCA C A C G T A T T T G A A A A C T C T GT T G T A T G T TCGGAAATCT A C A C T T A C A G C G G C TG C C G T A T G T A A A GTAAGGAGTTTT T G C A G T G T G AT T C A C C A A C C A A A G T A A AGAGGGTTAGGT C G G T GA T C C G T A C G A C T A A G G G T A G G C GCGCGGTAAGGAT T T T A A C T T T G G C C A GGC G A TA T A T G C G A A A A T TT T T CCGTCAATATTG G T T A G A C T A G A T T A C G C C CA T A T A T G A AAGTGTTCCGAA C A T A G C T A C T A C C TG T G A T A T G C A G A C ACAGTGTAGTCC T A G C G G C G CT T T A A C G T A G T C C A C G C T TACCTAATAC T A T A GC A T C A G T T T T T A A A G A A C T A C T ACCGTTGCCTAAA T T T G G C A T C A A T T A AGC A C CC T G G C G A T A A G A AT C T GTCTTCCTACGT A C C A C A G T T G A G A G C T G C AC T T A T A G G TTACCATCCAAA G T G T T T C C T T T T A GC T T C G A T G T T G A T CAAGATGTTTCA C T T C C T T G AT C A C G C C A A A A C C A G A A T AAATAATGTTCT T C G GCTA G C A G G G T T T G C G T A T C C T G C T CTATACTATAGCAAGTTTG A G T C C C G T A C A C C T G T C T C A T C G AC C T TTTTGACAGTAC G T A A T T C T T T A C C T C G C T AC G C T A G G T CTTTCCTCGACG A T T G A A G A C G T C C GA T C A T T A C C T A C A ATTTGTGAAGTA A T G C A T G A AG A C A T T A G G C G C C T C T T A AGTGGCCGGTAA T T A CAGC T G A A T C A A A G A A G C C C A T G A G GCTTTCTTCACGCTGAAAAGC A T G C T T A T G G T A C A G C T A T A A T AA T A A TTCCCCAACAGT T C A T A A C T A T A C C A A A T AT T C T T T A A G TCTCATTTAT T T A T A C C C A G T T C CC G C A A A A T G G A A G AACGATTCATTA T C T G G T G A TC A G C G A C C G A T C G A A C A T TTTCTTAAAAGT G C C GnC T G A T A C A A G C C T A A A G A A G T A C TCCGTACGGAoit CtAT T T G C G G C C C T T C C A T C T A T T T T T G T TGGanTTeTTTTAAACC A T T T C T A A G C G C T A T G C T C C C C TiGTAATGAAATACTCCCTGGAAGAGTGAC T C A G A A T A T A A T A T C A C G ATAGATCCACCATATT T G A A A A T A A T G C A C ATGTCTG G G C T T C A T C A G C Gr T T C T A T C A A A C C G A TTCACTTCCT A G G T C C T T Ao3 A A T A A C G A T A A T T G A G A C TTGTTGAACT T C C C G'- T C T C A T T A A A T T G T A A C A T A C A ATTCCACCTC T5 GTT A G G G T A C G C A AG C'T G T C T T C C G C T G T C G TGCAGGTCA A G G G A T C A A G A C A A T C T T T A A A C AnieCcACATTGTAGCCGTTACTTG G T G T G A A A A G T A G C T T C A C AGGTATTAGGG T C G G A T C T A A T G C A C GnAeTCuGCTTGTTTATATTGCGCTCTATATGACCCCA T A T G T G G T T A C A GGCTCGTATAT T T T T C C T C AqTCTGTAACTACGCAAGGTTTATCCCTGGAGGGGCCGACTTAACCTGCAC A G C A CAAACTTATGT GeT A A A G T T C C A T A T A A G A G A T C G C G C A GCAGASGAATTTACGTTTTAGGTCGTTTACCTCTCGGACCAATTGTTAAACGGTGAAGTCCCGGezislato)p44Tb(82OQNESDI83PeMV LCm_aGA9NR R10G C A T A T A A C T T G A A A A C C T T C T A T T G A G T TAGGTCGCCTATACATGAATAGGG T G A G G T C C G T A C G A TA T A G T A A C A A G CAGGTAGAATCACA C G A T A G T C CG C A A G A C G T C A G G C A A C ATCCCTGCGGAT G G C A GA T A C T A A A T C C A A C C A G T T T G T AGATCTCCTAGAT T A A G A T A G C G T C G A AAC T A TT G T G G A T T C A T A AG G A GAGAACCACGTG G G G C A A G T C A T C A A C C A A TA A A G A A T C ATCAGTTGGGGG A T C G G T C C C T G T G TA G G T C G T A A C G C A TTGAAAGCTTTT T A A T C A A A TG T A C C T A C G C T G G C A A A A TTCGTCTAAGAA T A A TTCT A G G T T A A T G A C G C A A C A C A G T ACCCACGATAAGGTGTTTGTC A A T G C A A G G A T G C C C T T A T T G C AG A G C TATCCAACGTGT A C A T A C T A A A A A C C C G T GT T A A G A A C T TAGATTAGGTCA T C T A G C T C T A G T AA T T T T G A A C C G T G T GAAACTCTCCCG A T G A T T C GC A A A A T C G A T T T G G A A C G G CGTTAACATTCTAT C TC A A G C A T T C A C G C CG G CG CG A G C T C C C T G T T T T GA TAAGATGTTCCA T G A T G G G A G C T T C T A G C T C C GC T A C A A CGTGAGTGCTGG G C A C G A T G A T T C T T A GC T A C T G A C T T G GGCACGGAAGTA T C T C G G T C C C TT T A T T C C C G T G T G C A A CACCTGTACGAA G G A G C TA T A T C C A T T G A C G G A A G A A G A AAGACACACCTC TG T A A G C C A G G G T A A GG CA T GA T G C T A A T G T T C T CC T TAGTCTTTTCATTT G A G T G A T T C T G A A A G G A G CC T G T G A A A CATGTAACCTAC C C C G C A T C G A C C A GC T G A A T G T A A G A G ACCTCTCCTAGT A G G A A A A C TT T G C A A T A C G G T G A A T G C ATCGAGTGGACT A C C CTGT A C A T G T C T T A G A A G T C C T G A A AAGAAAGCCTCACTTGGTACC G T G T C C G A G C T T G C A A A T T G A T AT C A T GAATACTGACGC T G A T C C G G T G G C C A T C A GT T A T G A A T C GGGCGTTCAGCT T A G T G T G T G A G G GT C A G G A A T G A G T T T GCAATGTACGAGAC G C T G A G GT T A T A T A G T C A G C A G G C C T A TCGTGAAGGAAC T AT C G A C A T T A G A A A AA G AT TT A T C G T G G A A A A G T AG TAGAAATAAGTT G T G G C A A A C T A C G A T G C T A G GT A T A G G GAGTAGAGATGG G A A T T A T T G G G G C C T GT G A A A A T G A G G AACATGAGACGT A C G T A G A A C G AT A T C C A C G A T G G C C G C TAAATTTGACCC A A G A G CG T A A T G G T G A T T C A G A C A A G A TGGGTTTAGACA TT A T C A A T A G A T A T T AC TT C G TG C A C A C T A C T G A G TT T A TCCCTAGCTGCA G A A C C T C G G A G T C A G A A A CT A C A G C A T TTATATAATTCG G T T G T A C A A T C A C AA T T C A G A T G G A G G TGAGGCCTAGTC A C C T G A T G AnC A T A C T G A A G C T T G G T A G CTATCCGCAA A T G A Coit TtTGAAACAACAGGAGGAAACCTACCCC T C C T G C C A GAATTAGACTATAa C C C G G G A G G G G C A A A CnTeTTiTGTTATCTAGT A A T T G C T G C G G A C G C G A G T T T C G AGATGCCACTCGATATTTT T C C C G A T C C T T C T C T T A A GTCCAATCA A A C G A T A C G T T A T C A Ar A T T T A A T T G A T GCTAAGGCTT C C A C A C T A A A C Co3 G C C G A C C A A C G T C G G CGCCTGAAGG G C T A G T A T'- AGTTCTAACTTCGTAGCGAGTTCGGGTGCTACGGTCATAAGCATCCGTTAAA A A G AGAAGATAA A'5TGT G C C A C T A T A T T G C G A C G A T G G G G T CAAGGnieTAcAGGGATAGAATA G A G G A G T C A T A A T C T G T G T T T C TCAAGGACAGGAG T G A T T A C C T C A G G A T G A GnAeAGuGTGTTGTGTTTTAGTAATATTGTCCGCCCC A A T A T A A A A A C T C GAGACCAATTA A C G C T T C T C CqTCCCGATCCAGCCTGATCATAGCGGGACCGCAACGTAGCATCTTAGG A T A A A TGGGCTTAAGA G AeC T G C T A A T T A C C A C C G A C G G A T A G A GAGAGGTSGATATCGAAGACTCAATGGACCCTCCCTTGGTAATTTTTCCTGGCATCCGTTGTGGGAezislato)p5Tb7(51OQNESDI93PeMV LCm_aGA0NR R20G G A T A A G G C C A T A A A T T C G G T C C T T G AGATCGAGACCTCGTCCTTC T C T T C G C T T T C G G TA T C A A T A T C AGGTTTTCTTAA A T T C C G T T CT C C A A T A C T G G T A C AGTAGTCAGTCCTA T T GA G T C A T A G T G TC C T TTC G T T T G T G A A A C C TAAACGTTCTCCCCT G G C C T T C C T T T C G C G G AA A G A C A ATCTCTTGGTTT A A G T C T T C C T A TT G G T A C A C C C G GAGTGTTTTCTTCC C G T C A CA A T C A C A A A C C G G T T A A ATCTGAATGACC TG C T T A C A A G C T T AC AG C C TG G G A A G A C A G T CA A T AGATGTACTTAA C A T T T G C T T G T A T C CA A A C C T C C CACGATAGTAAATT A T C A C G A T GT T T C T T G G G C C C C C GGTTCTCGCCAG T C A AA A A C A G T T A TG A C C GTT A T T G C T T C G T G C C AGCGAATCATAGA G T G A A G T T G G G C A T G A G CA T A C C TAATGTAGACGACG G T G A T T G C T C A GC T A G G T A C C T T CCGAATTCGAAT T T C C C T GA A G T G T T A A C T T T T A T AGCACTTTCAGG T GT C G C A T C C C G T TT T AG CA A A T T C C T A T C T CA CAACAGAGTTCGGT G C T A A A A T T C T C T G C TC T G A G C T ATGAGGAAAGGA C T C C C G A C T A GA C T A G C C C G G G A GAATTTCTTCAGTT C A A A AC C G C T C T A G A G A A C T T A T ATTTCCATTCTAT T T G T T G C T C A C A CAG C G G TA A C A T T C C T T AG G A G CCGTATGCTTCA T A T T T A T T G G C C A TA A C A C C C T T GCCTTTAGACTGA T T C T A A C G AG G A T T T T C T T T C G T T TAACAAGGTT C C C T CA T C T C C C G T C T T T G G A A G T TTTGTCAATGTGT A T C C A T G A C T T A TGG C TG A T A A A G C A A T GA A CGTGTAAGTAGA G A C A G T A T G T C T A G G T TA A A C T G A TACGTCTGTA C G A A T G C T T T G T CT G A A A G G C T C T TGAGATAATTGT T G T T A A A GG G C A G T T C C C A T T T T T TTTCCTATGC C C T GA A G A T C T T T T A A A A G A T A A G TGGGGCTTCGG G G G C C A C G C T C T ACG G TA T A T T T T T A C A TT T GGTTAAGGTCAT T A A A T A T C A C T T A C G C CC C T C T T C GCCTTTCTTT T C G G T C C T C A T C GT G C G A A G G A C G CTATGCGAGAGA G C G T T T T AC G A A C T T A G C A G A A G C TTTTTAGTTA T T T CCTT T A G C A C A G C T T C T T T T C G TACAGCATGTTCGTGTCTT C T T G T A T T T G C A G C G G A G A C TC T G GAAATACGTTCC C A A T T G T G G G T C G T G Tni C A T A A C A A AACCCTCC T T T G T T G T G T C A Tot G G C A T T T C A C A TTCTATTATA G G A T G C G G AtA G G A A A T A T G C A A T T TTTTTG C T T G T G TanA G T A G T C C T A C C G T T G T TCACTGTGAT T G TeC A C G A A T G A A T C T T C T A A A G T CGATTAATiCGC G G G C A G A G T G T A A A T C G G T G A G TTAr TTCTTGAT T C G A G C A T A T A C T G A T T A G G Ao A G A ACACTTTT T G C G C T A A G G T C G G C T T G'3- AAACCCATCTGTGTTTCCTTTTG A A G G G T G G T T A C C C TATCCGTCT A A G T T G T G C G G T'5GAGGGGCGCGTTAAAATCGTGGGGTTTTTTTC T C A A T G T A T A TTATTCTTC A T T C A C G CnieAcATATCAATCACCCCAAAACTTACTATATTGAGTATGTTCCG C C G A A TATTGGGAA C G TnTeACGCGTCTCCAAAGTATTTAGTGGTCTATATTTTGTAAGTTACCGTTCTTA CGTTGTuAqTGeTTT A C A A C A A G A A T T T G T G G T C C T T A TACATTCCTCATC C T A C G A T T T G T T A T G C C T A A TAGTC C A G T A T G T T T T T T G G G C C A AS C T T A T AAGGTATACCAATACGTTTTATTTTTTCTGAGTTCACCTATCAezislato)p43Tb(01OQNESDI04PeMV Cma L _ 1NGRAR20A T G A A C T A T C A G G G C A C T A A T G T T T T T A GCTGGCTTTCAAGGGCGCGGAGGATG G A T T A C G A T C C T AT A A G G A T C A G C A TTCGTTCTGTGGGG T C A T T T TG C T A G C A G C A T C T G G G T A AATTGCGTAGTCTTACT T T A T C C T G C T T C G AGC A A A AT T T A T C A C A T T TG C A A ATGCTTTACACGTACG G G G T G G A C C A C T C AT C G T A A A T A T C CTTCTTTTATTTTGAA C A G C T C TG C T A G A T A T T T T A C C G A T GACGAACACTTGCTAAA T T C T G A A C G A C A G TAG T A G AT T A A C T G C T T G GT C C G CGAGAGGGAGTATCTA A A C T T A C T T C T C T TC C A G T T C A C G G AGTCACAGTCCACG G T C T C C A AT C C T G T A C A T T G C T T A A CGATTTACTCTCGGAT AT T T C G A G G G G A T T AG CC G A GT A T T G T A G G G C A CT T A GTGGTAGACGGGTGAC T G C C T T A T T T T T G G CT G C G A C A C A C CCCCCGGGTACTTTGA G C A G A T T CT C C C T G G G T A T T C A C G T GGAGTGAGTTCCGGGC TG C A T G T A G G A T C T TA TG C C CG T G A G T C A C G A T GT C A GTGAGAATGACCAACC A T G C T T A T C A T G C A TC T G A T C C A T G AGAAGCAATGAACT T T G C T G G A CG C G A G A T A G A C G T A C C ATTGTTATATGTGCCG A CG T A C G C C C A A C A GA G CG T AC T C A C A C C G A C A G AA C GCTTCCTGACATGCGG A T C A T T C A C G G T G T A CC T A C A T C G A AGTGAGGAGTGGTGG C A A A A T T T A AG A T A A G A T C T G G A C C T GATCATTAGGAACC C C G AACC T G T T G T G C C T C C T G A A G C A G ACTCCCCATAGTCATGACGTAGA T T G A C T A T G A A G C A G C G C G T TG G T A G GGACCGTTCTAGTC G C G G A A T A A T G C A T CT T C T A T C T C A C GCCTCGTGATCAGT T A C T G A C T CG A C G C G C A T A T A G A T C C GATTACGCGAGT G G G TA G T C C A G C G G T GC T T A CAA G T C C T T A A T A C C C A AGGGCTCTTTGGATC A G A G T T A G C A T A C T A T C T A AC G T A T A GAGGTTGGGTGTCA C A T A G G A G T T G T T CT T T C T G G C A C A A T GACATCCCCT T T A A T C G A A TC A A A C T G T G C T G C T C T T CTGCTTTGACCT A T C A CA C A T T C T A A G G A A G T C T C T T A G TCCAGTCAAG AA G A T T A C C G T C A C G TA TG G CG A A G C T T T G T C C A TT T CAGCGCAATC A G G A G T T T A C A C A C T G C C G T TC T T T T T TCGAGACAGGTC C G T C T C C T A C T A T A C TT C A T T T A G T G T AGTGTCTATACT C G T C T C G A T G TG C T C T G T T A A C G A C A C TACTTAATAGTA A T G G A TA T G A A A C C G C C T C G C T T T C T G ATACGTAAGA G TA T T A C G T C G T G A T AA A TnAA A A T T C G T T T T G A A Toit ACTCCTTTCTA A T T C C A A G C C C C C G C T C T A A T C G TTTTCATGG A G A G T C T C A C T C C C C T A T G A TatnCeGCCTGTACGACGGTGGAAAAGT A C C G G G G G T C G C G C C A C TGTTCTACCTG A A G C A G T G G C C C G TiAAGGTCCTTTTCATAGACTTCCGTAGCGAAGCAACGATAT A A A A T C A A G TCTGAGCTA G C G G C A Cr G A T C A T A T G T T A A T T G G T A A GGGGGACC T C C Go G C A C T T A C A T G G A T C G G T A G A T T GTCGAGTTCT'3- T C C A C A A T C G G T G C A G A A T A A G T A A A T TAA'5 CTTTGTGTT G C C T T A T G A C A G C C C A T A C C G A C AiT G G AACTGTAT C T A A C G T C A A T A C T A C A G A A AneGcAT T G C G ACGGATTGAA T G C T A G T C C G A A T T A A AnCTTGTTCGAACAAGAGTGTACAGCAGATCCGGG A T C A A T T A C T A T ATAACTACCCA A T A T C C G G TeAuCAACTCTGAACAGGAGATTTACCCTAGCGAATCCAGGTTGTAGCTG A G C A T CCATTATGTTC G CqT G C G C G A A T T G T A T A T A T G T C G C A A TAGACTTeCTGGCCT G T C A A A G G T G G A C T G C T G G A G T G A CS G G TCCGGTGAAGTTTCAGAAACGTGTTCGGGTATCATGTAATTTGGAAATTACTGezislato)p 5 59Tb(2377721OQNESDI142434P V P PeM MV Vma LC_CNGRA2 L _MCR20GRA3 L _R20GRA4R20A A T A A C A A T G A C A G A G T C A C A A G A G T G G TAACCAATCGAAACCACTTACTAC A G G A T T C A G A G G T TC G T T G C C A C A G TGGATAGCCATAGT T A G T G A T GT G A A T G T C T T G A G A T C C TTTATTGTCGACAC T CC A T C A A T C C C T T AT T TT G GG T T G G C C A G G G T T CC A AGGTACGTTTGCTT C T C A T C A C G C T A C A G T CA C C G T A A C TTCCTTTTGAATTC C T T C T T T G G T AA G T T A C G A T C T A A T TGCCCCCCATAGAGGC T G A GC A C C C C T T T C CT T T A TCT A A T C G A C G A A C T T T CAAGCCGGATACGAC G G G G A A T T A G G T A C C T C C CA T T G A T ACCATATACGAATT T C A T G G T A G T T G TC C G C C G A T C T C T AATTTGACCCCACTTG G A T C G CA A T T G G C T A G T T C T T A A T C AATAGCTTTCGGCTT G C C T A G C C A T C G T TAA C A G GC C C C T C T C T C C AT A T A CGGACCCTCTTTTG G C T T C T G T G T C T C G CT T G G A T C C G G TAAGTATTTTCGTAGG A A T T T T C TC A T T C T T A A G C T C A T A C CTCAAAATTAGTTC A GG A T A A T C C A T T A GG G TA G GA T C C T C C C A T T A C GG T ATTCAGTAACTAGG T G G T T T G C G A A T C T A A GA G A T T A A G AGTAAACGCAATTC C T C T C T G T C C TT G T T G A T C C C T A T C TGGGGGGGCCATGC A T G C AAAA T A T A A A C C T A C G C T A T C A GTTCCTTTCGTGGCGGTCGAGTTAA C C A T T G A G T C A A A A G C T A C AA G G G A AATAACGATGTTCATT T C A G C G A A G T C C CC T G A T T A A T T T T TCTCATATCGACGA C G G T T G CT C A C A A T T G T T C G G C G A C ACCCCTCGTTTCGC GG T C T C A T A A G T C T AG AG C T CG C G C G A G T C T A G TA T A TATTAAGAAAGTGGAT A A G G G G T C T G T T C A TG G G C T T C T A G T AATCCCAACTAA A G A T A C T T C GA A A C C T A G A T T G T G A C GTGTTCGAGGAA C T C A TA T G A T T A G T C G A T T A A T A G G A ACTTATTTATCGG A A T T A G T C A A T T C A TCA G G C CG A T A A T T A T G A CC T C C GATAGCTGTTCC C C C C A A T A C C A G C T C G AC A C T T A G C C TGGTTTCAGTGT C G C A A A G T C A G CG G A T T A A G A A T T T T AGTGTAGCATTC A C C G C G TT A C G T A T C G C T C T G G G G C C ATCATATCAGTG T TT C C T A T A A A G C C CG C TA GT A A A A T G C A G A C T G GA GCTTACACGG G G G T T C C T A T G C T G T A A T C G A GT G C T T TTTTGATGTC G T G C A T G T T G A A G G G A T GC G G A T C C T C CCTTCATGATTC C T C G T A A G A C C G GT A A T C A C A T C A G A C CTTACCGCGG C T A G C A G A CA C C A G G T G C T A A A G G A A G AGGGTTTGAA A C T A AnA G C T T T T T A C C T T T T G A A C C G A GTCCTTAG C Goit T A T T T C T C T A C G T T T G G C T A A C A C T CAGCCAGatCnTTeTCC T A G G A G C C T T T T G T C C G A T T A A C G T AAGCGTTCG T A T G C T T G A A C C C A A C G A G G T C TiTTACCGGATTACGCATAAA A T G G C C C A G G G C A G G T C C C GTAGTGCGT T A A T T C T A C A G T A A G G Ar G A A A C G G A A G ACAGTCCT A G T C T C T G T C T G A To T T A G C T A A G A C A T TTCAGTAG C G T T T T T A A C T'3- TACTGGTTGAGCCTTATGCGTTCCCATAGTTCGTACTTCATTC A C A G T C T TTCGAAA G G G C C T'5ATCGAGAAGACACCTATGTCTCACTTATTATAACGGTATTGTTAAAGGGCTTG C C GCACGCGTAnieGcTT G A C C A C C C C A T A T T C T C T T C G C C A T CTGnACTAATCGGC A C G A A A T G C C A T C A C A A G A C G C TeAuAAqTTACGTGGAAGGGGATT G C G A T T A A C G T C T T A T C T T TCGGGAGTT C C A G T T C G G T C G G A C C TeCCGCATCCTTCATTGAACGGGGTTCCATGCATGTTATTGTAC T A G A T C T G A A G C T TTCCAGTATACGACGC T C C A T C G T T TATTTTC A T G G G C A TS A A A T A G G C C A A A T C G T A C G TGCTAATGTTGTCTGCCTTezislato)p 59Tb(80681OQNESDI4454PeMV P Vma LCG_MA5 LCG_A6NR R20 R R20T T T T G C T G G C A A A G C C A C A T A G C C T TCCTTCATCAGGAGAAGACCCA C T G C C G C T C G C GT T T C C T A C G T GCGTGCCGGACA T A C G A C AT C C T G C C G T C A G A T A CGGCCGCCCGATAT GT C T C C C C G G C A TA AT C TA A G A A G G C C T A CT A TGGGGTCGCGTGTG G C C C A C C A G A T G A GT G C C A A C A TGGTCTACAAGGGC C A T G T T G GT C T T C A C G T G G A C G ACCCGAGTGGAGGT A GT G T C A A C G T A AT C AT AG G A C C T A T C G C A CT AGATATCCTGTACG G G A T A C A A A G T G C C TC C A G A C G AGTGGTGTTTCCTC C C A A G G G C GG A T C G T C C T G G T G CCAACAGCGCCTCG T C AG C C A G G C C C CT C A ATC T G G C A G C G G G C C ACGGTGCGGTGTA A C G T A T C G A C A A C A A A G AC G A G C CCCGAGGGGCTC A T G G C A A G C C G A TG T A T G G G C T G TCATTCGGCGGG C A G G C C T AC C C G A G A A A G C G G G T AAGTCCGTGG C C C CGCC C A T A G C T A G G G G C C A A A TTTTGACTCGGCTCGGCGGAC T A A C T G T G C C C A T T G G G C GA A C T ACGACCATGCGT T G C G G C A G C A A C G TC A C G C G G G C ATATAGGCTG T C C A G C C A A CC G C A C T G T A A C G A TACCCCGCTCAG A A C A GG A G G C T A C T G A A C A C C A T CCAGTCTCCCCGA T T G T G C T T G T G C CGG C G TT T A C A C G A T G CT T T CTCTGATAAA A T G T A G A A A C C G A T A TG G C G T C T AATGACGGAGTC G A G C C C G A C A CC G A G A C A A A A T G CCCGCTCACACC T G G C C GG T C A C A G C C G T G G C A C G TAGCCGAACAAC AG C C C T C G C T G A GC CA GT C C C A G G A C G C T AC GGACCACAGGAC A G T T C A A C A A G C G C T T TA A G G G A CTAGAGGCTGTG C G C T C A A T C G T GT C T C T T G T A T A TTGCCGACGACA C C T G G C AT C G T C G T A G C C A G C G T ACAACAGCCT G C CA C T G C A G G A G CG A C GGG G G G A G C T A C T A A TGGTGGTCTCT A A T G G G T C G G A T G C C T C G GG T A T TTTAACCTTAGA G T C T G G G G A G C A A CT G C C T T C T A GGATGCCCCC A A A A G A A C C CC T A G A T G G C A C G A GGGGAACATACC C G A A CG A T G G A C G G G G A G T T C A C AGGAAAACACACT T T T C C T C G G G C A CGG C A CG T C A A A C C G C CA C G TGATGCCCTT T G G A G G T C A A T T C A A CA C G G A T G CGCCAACAAA T G C C A G C C C C G C Tni A T G A C T G T C G T GCCCGACC C T A G G A C T T Cot C C T C T T T T T G G G G A CCTCCGTC T G A C G T TtC T C A T T T C T A A G C C G C C CTGC T T T G A TanC G G G G T C A T C A T C C G C C A ATCCCACC G G CeT G T A G A C C T G A A C C G C A C A A G CCGGAACGiC T G G G A G C A T A G A C T C G A T G G C G A CTTrCGGCA T T A C A C T T G G C G C T C C A A C G C C To G AAATTCCT C T T G A G G A G A G T A C C T G G A A'3- TTGCCCTTACCGCACCCAA C C G G C A G G A T G A C A A C CAGACGG C A C C A T G C T C C G G C A'5CCGACTTTCGCCCTTTACGGGGATGC C A C G A G T A C G G C TAAATAGAC G C C C A T T T C TnieAcCTGCCTTCCCGAGTTGGAGCGGGGGCCACCGGAACCCC T G A A G C CCTGCGTAG G G G GnCeCTTGAGTTCCATGTGGAGAGGGTAGGTCCCGGGTCTGTCAGTCATCT G TATGTCTAuGqCTeCTC T C T A A G G C G A C G G A A T C G C C T T TTTGATTCGATAC A A G T T G A C G T G G A A T T T A C CCACC T C G C C G G A A T A C C C A C G A TS A A G T G CTCTCGGAGGAGAGGTCCGGGCACGTCAGAACTCGGATCACezislato)p64Tb(01OQNESDI64PeMV Cma L _ 7NGRAR20T A G G G A T G A T G T G A C T A G C A A C T A T TACTCTTGGGAGGGCAAATTAAGTAAGCAG G A A G A T G CG C C A T C A G A G G A A A TAATAGGCTGGCCCTT CC C C C A A G G T C G C G TA GC A G A C GC A T G C T C C C AT C A G G AGTGGACCGAACTGTC A A C G T C G T A GC T G A C C G G G T C T CCCTCTAGGAGGGGTACC G AC G A C A A C C G A T A GG G CG A C C GC C C A G G G C G G GA C C C GGGGGGGGTCGGGCTGAT A G G G A A C A A GC T C G A A G T C G G C GCTAAGGTAAGCAAAG C C GC C A A T A T C G T TT A T C AT TG G T C T C G G C C C C A CC CCAACTCCTAGTAGGC T C A A T C T C G C T C T T TT C T T T C A A CACAGGCCGAGCTGGG T G C A C T T GC A G T T C C A T C G C G A G GAAACATTCCAACC C AA G G C C G A A C G T A TG T AC A T CC G C A A A C G T T C AC G T CCCCCGAGAGATCCAC T C A T C G A G A T T C AT G C G C C C C A C ATAGATATGCGGAGGG A G T T C TA G G T C C T T G C A T G G G A G ATTCCTCTTACTCAT A A A T C G G T C G C G G GCA A G A A CC T A T C C G A A GA A T A A TGAATCCGGAGTATTA G G T C C C C T T C GC C C C T C C T T T G A AACATGTCGGGATGTT C T G GG T T T T C C G A CT G C A TGT T A C G G A G T C T G G C CGTACGACTTCGCCGAA T A T C T T G G G T C A G T A GT T A T T T A AGAGGAAATCACGAGC A G A T T A T C GG T C A G C T G C A C T C G CACAGTATTCCTGCTA G GT C C T T C A A G T A AT A CG C AT C T G A G C C C T C C TG A TTGCTTGACCGGACTG C A C G G G T A A T T T A CG A C G T G A G G ATCAGCCTTTGGAGAG T A A G A C GA A C A A T C A G G T A T T G C AGGTTAGCCACCCCCAC C A C C C C G A T A A C GGC G T TT T G C T T A T A G T AC A C TCCCGCTTCGGCTG A A T C A G C C C A G G A A CG C C T C T C C A TAGCCGTCGATC T T T T T C T G G C CA T A A C G T C A C A T G A GTGCTCTTGAGA T A G A A CA G T C T G A G G G A T T C A T C T C GCCTGATGTC G TA G C T C A T A A T C T CG T TA GC C A A C A T A G A C G C CC GCATTCGGGT G A T G G C C C G G G A G G G A A G A TG T T A C GCCGAGATAACG A A T C G T G A G T A A A G CG C C A T A C A C C AACCGGTCTG G T A T G C C C C A TT C C T C G T C G A C T G T TACGATAATCGT C C A T C TC C T T G A C G T T C C T A G A G C G AGTTCGGCGGAT TG T T T T C C G C T A C C CT CA T TT G A A A G A A C G A C Tni A C CTTAGAGC G G C G A T A A T A T C A T A C G A T Tot GtACTGAATACATTGATCATGG G A T C G T A T A C T G C A A T C TATTGGA T G G C G C G G G G G C T T G CanC G G T T A C G G A TGATCCCT C A G A G G T T A A C T TeAiGAAGCGGATTATCGTATGCGCGAACTCCTTGCATCCCTCCTAATTGA T G T A C G G C T G TGCCGATAAGTTA A T T G G C A CCCGACG C A G C A Gr C A A G C G G C C A A T C C G T C C A T GGTACTGG T T To C G A G T G A T C C G A A T T C T T A G A C C ATCCTC T'3- T T C C C G T C C C G C C T T T A A A T C G G C G CGGTA'5 TAAGAA A T C T C T G G A A A C C C C A G G A A G G T T CTGACCCCA A A G A G A C A C A C C C G G C G T G A G AnieAcAGnGCTCAATACGAAGC C G G T C G A C T G C C A C T C C T T TATCCCACG A T T A T T A T G G C A T T C C TeGTCTCCGACGACCTTTAGGGTGTACTAT C G T G T A C C C C C C T CGCCCGACT A T C C G G T G G T GuTqCACCTGTAAGGTCTAAGGACACCAGGTTTCCTGCGGA C G T G C A C A TGAAGAAAT A G G C C TeCCCTTATTAGTGCACAGTCTATTACCGACGCCTCGATGGAGGTTCAAATGA C T AACCATC TS G C G T G G C G A G G G A G C T C C T A C G T C T GGTCTezislato)p 49640 8Tb( 6 50561OQNESDI74849405PeMV P V P V P Vma LCG_MA82LCG_MA9 LCG_MCA0 LG_A1NR R 0 R R20 R R30 R R30G G A A A C T A C G T A G A C T G T G A C A G T T C A T A CTCATGTATTACACCTATTCACTA A T T G T C A A C G C T T G CT C C C T A G G G C G CGACCGGGTAAAAG A A A A A C G A CT T G A G G G T A C T C G A G G A TGAAAATTCTTATA T C CT T G A G A A T C T T T GC T A GG CT A A A A C C G A C A A C G AT ATCCTAACATATGC T C T T C C G A T G A T G A G G A G AT C C C C A T ACTGGTTTCCGCGA A A A G T G A T T T A G AT C G C C A C A A G C G G AGACTAGAAAGAAGTG A T G A T GT T T A G A C G A G G G A C G C A T C A ATGAACATATTATTT C A G G C G A G A T A C T A TCT C C T CG G C A A A A A A A G GC A C C CTAATGGACGACGT C C T C A T G A G G A C C C G TC A A T C C G A A T AAGCGCGATCGAAATG T A A T G T G A AT C C A G T T C A G T C G T T T A A GAGCAGGCAGTA A G A TTGG C C T C A C A A T A G T C T C G A G T A G ATCGTTTAGAACTGGTGAACT C C G A A C A G T T T G A G C C C T T A C A GG A G G CTCTCTTATAAAAA G T T T C A A T T G G T C A T T GA C C T A G A C G T TATAGCTCCTTC G A T C G G A T A T A TT T A T C T C C A A C G A C T TACAGAATCTAA G A T C T A CT T C C C T A G T C G T T G G A C G A A CGTTCAACTTCT T CT G G T G T T A T A T A G TT T CG GG T T T A C C C C G G A A A AG CGAGGAGACGAC G C A T G T G A T G A G T T G T A C C C AA T C T T A ATGATGGGATCA C G A C A G A C G A C A G C T AA C C C A T T G T A T CCGTGTAATCTC A C A A C G G T T T AA T T G G T A T A C T G A G C T AAACTCCAAGGCTT T T G A GT A T G G C T C T C A A C G T T C G A T G G CCTTCCATTTTGC T A A G G T A T C A A C G C TAG C G TC G C A T C A T T C C A GA A G CACTTATGAGAT C G C T G T G A T A G T C T T C A A AG C G G A A T G ATTCGACCCAGGGT A A C T G C G C T A T G TT G T G T T G A T A T C A A TAAACATGTGTC A T T G A A A AC G C T T C T G G C C A A G C T T T C CACTCCACATCA A C AT T G T A T T C T A G A CT G T AGA C C T T A A A G C C T C T T CTGAATGTGGACATC C T G G C A T G G G A G A A C A G T C G CT C G A G C CGGTAAGTAGAG A C G G A A T T C A T A C C T CC G A C T G G T G G G CTTTTAATCGTA C A C C C A T T A A CA T G C C A A T T A T G C T A C TATAACTGGCTG G T C T T GA G T A G G T C G G T G T T C G C G A T T GTTAACCGAAAA GT A C T T A A T G T C T A T TA GA G CT T T G G C A A A A C A A AA G TTTGACGTTCAA C T T A T C A C A A G T T G A C G A T TT T T T A G A CGGTTCATAACT C T A C C T T G A C A G G T TT C C G A G A T A T C C TTTTACAAGACCGG A T G A G A A T GC G G C C A T A G T T A G G T T T C TACCTCCACTTA T C A CT G T G C C T A T G C A T T A C T A A G A A G AGTCTCTAGGAn Ti TACCGGTC T A A A A T C C T T A C G A T G C A A A T C G Cot T C C ATAGAAGTATAG G G C T C C T T C G A G G T T C C T GtT C C G C A A A AGAGAGTG T A A G T C G G G T T A T T C GanAeGG G A C A C G G A A AGTAGCTCGG A G G T G G T A C T T TiTTTCTGCCCACTCACTAACTACTGTATACGTCTGGGGTAGCTGTTAGCCGGCGGAGTCACT C A A G C T C GAGAAGGAATTGATAAACC T A TTTTTCGAGr C T T G C C C G G T C T G A CTo T CA A G A C G G T A A T T T C'3- AGTTCTATTGTGGTGG G A C A T T C G C C T G A G G C C T A T G TGGTTAACGAC T G A T A C G A T A T G A A G T A T'5TGGTAGTTTCTCCCACTTAACTCTAGTTCTTT T C T C T C G A A T A C A CTAGCAGTGGT A T C G A C T C A GnieAcACATGTACAGGGTTGTGCGTGTCAATCTAGGTCATAAAATGTGGAGG C A T C A AATGAATTTCAGA CnAeTT A T G G G A A G G C C G C G T A C T G C G A C T GAAGTuTAqCGACGTCCC A A G A G T C C G T A T G A T C A A T T T A GeTGAATCTTGTGTCTCACGAGACTAGACC A C G A G C C T T A A G G A T A C A ACTCTTAACTCCGCGCGCT G C A T A C A G C G A C A CAGAATGTG A A T T A T A A A G AS T A G T T G T T A A T C T T C G CGGCAATAGCACCCTTAATCTGACTezislato)p7Tb3 8(2413OQNESDI1525P V PeM MVma LCG_CA2 LG_A3NR R30 R R30G A T C T T A C G A T G G G A C G G T C A G T T A G A A A AGACCCCAACAATACTGGGGTG G T A T A A C G C T A C C A G AA C A T T C G G A G AAGGTATAATCAGC C G C C C T G C A CT T A C T C G A T T G A G T T G AGATCGCTCTCGGG T T C TCTG C T A C G A T A G T G A C A A G C T C T AAGCTCAGAGTCTCTTCTGCTTA C C A T C A G T G C G G C T G T T C G C AA G A T C CCGTCAAAGATCAG A G A A T A G C A C C G G C GA T T A G A T G T T T AGGCAGACACACGA A C C C C T A A TA T C A A C A A A A T G G G T C A GTCGTGAACCAC C A A TG T C G T G T A A T G AA T C C GAG A C G A G C A G G A C C T T AGAGCTAATCTTCGA A G A G T G T T A C G G T G C A C A C GA G A G C A TAGAGTACAAGGGA C C T C T G A T G A A C G GA A C A G C C A A G G A TTCCTATATCGT G C C A C G G C AA C A C A T G T G A G G A A A A G TCTATGGGACCGTA T T CG A G A A A A T G T G T GA G T CT CA G C T C C G G C A A A A C CT AGTGTATACGTGGA T A G T A T T A G T A T C G G G A C GA A C C A G C TTCTGCCTAGGG T T T T T T C A G T G A C GG A C T C A G T T A A A TGGGTCCTTTCACT C A G A T A T TG T A A T T A A C A G G G A T C C T TTTTGGAACGTTCC A GA C C C T C T A T A G G T GG A TT G AA A G C G T A C T C C G C CG A GGATACAAATCA C G G T T A A C G A A C G T C A A A TA G C C T C C AATCAGAAGACG A A A C A T T G G T C C A G AC A T A G G C A C T G A GGTCAGTCCTCC G C T G C T T A A TT G C A C T A A C C A A A G A T T TTTTTTTTTAGC C A C A AT T A C T C T T C G G G C T A T A G G T C A AAGCTAACGG CT A G A T C T A T T A T G A CG GG A AT T A G T G C G G A C C T GT C CTAAGCAACTAT A G A C A T G A G A A T G T G G C T A TT C T A A C G AACAAATATGTA A G C G C A T G C T T C C C AC C A A T A G T T T A A GGAAGCACTT C T T T A C G T C C CG G C C T T A G T A A G T A A C CAGCTCGACGGT T C C T A AT T C C T T C T A A T A A T C A G A C G A GAACCCTGACCG CG C C G G G G A G T G T C A AA TG A GA A G C C T C A G C C G G GT C ATAACTTGAC A G G T C A A G T G G C T A C G C G T G GA A C C C T CTTATTAAGTGT G C C C T T C C C C A A G C C AG G G A G T A A C G A ATAGTCCTGTCT C G G T C C A T C T AG A T G A A C C A A A G A A A T GTTTCCATTCTC C A C T C CA A T A G C A T G A C G A C A T T T C C A CATACCGTGG T CT C T C T A A T T T C A A GT A TA TG T C T A C T A G G G G C G GT GACACCCCTCCA A G T T G A G G T T A G C A T G C A A G TT G T C G T TAGAATTCTATT A G T G T C C T C C G C T G G TT G C A T G C G G A A AATGTAACTT T G C A C C A C T T C CA A C T A A T A A G T G A C A AATTGCCGTCCG C C C C C A AT A G T A T A T C T T A A A C G C T A G GTATCAGCGCGC G Gni C A G G T C C C A C G G GG G Ao A G T T T C T A G C T G T C G Gt CtTAAA G A C T G C T A A A G G A C A T A G A T G C C A T AanTeCTCCACCAATA A T G T G T T T A A C C C A A A C C A C G GiTCGGAATATCCGGAAAAGCATTTCTGTCGCT A T A A A A T G G C C C A C C C C GGTAGATCCGAGAAAG G T A G G G T C G T T T G TCTCATA T C A G G G A C G C A Gr A A T A C A T T T T A T G T T GCTATTCCAG A G A G A C G Go3 A T C A T G C T A T A T G T T G G C T TACAAAGTCG A A T A'- A T T C T G G A C T G G A G A G A G A T T C G CTCCATCACG5 GAA T C A T A C C C A G AA'T T T C A G A G A G A C T C G CAGGGTCCC G C C G A A T A G T G A T T G A A A A C G T G CnieCcCATTACTTCGTGAGCGATT C A G A T T A C A G G A G C C T C C G CCGATCCAGAC A T A G C C G A A C A A A T A GnCeGAuAGTTCTTTTAGAAGCACACGGGACTAAAAAA A G G T A T C C T G G T GGCCACTCGCC T C C C T A G C AqTGACTTAGTCGCCGTACTGACTAAGTTTCTCTTCTAGAAATCTGACTGC C A T T ATTGTGCTCTT TeC G G G C A C T A G A C A T A T C A C G G G C T T T CAAAASGGGGGGTCTTCTAAAAGTAGTTAAGTATGAGTTACAGTAGGTACCCACATTCAAGAAGezislato)p 7Tb(76OQNESDI35PeMV LCm_aGA4NR R30C G G G C A A A T G A T A T T A A A C A A C T T G T A T ACGTGCCCACGTGGCGTAGGTGAT A A A T A A T A T A A T A GC C G G G T A C C A T AAGCTTCGAACTGG T C T G C A G CC C T C G A A C T C C C T G T G A TTTCCTTGTGGCTAAT TG G G C A C G T T G A T T CA AA A G AA G A T C T G G G A T T AG A T CGTAGTCCCTGATTCC G T A A T T C T C T T G A T AA G A C T G G G C C GCGACGCATGGGTT C T G T C T G T GC A C A T T G A T C G T T T C A TATATAATTAGATTCA C AG T C G G G A C A A A C AG C TG T GG G T T T C A C G C C G C TG T GCGGGGGCCTCCTT C T A T A T T G A C T T C C A T AA T G C A A C C AAACGCTATCGAGG T T G G C T A C A T GC G A C C A C A T T A C C T CTGATTTAAAATTCTT G G A GTGG G G G A C C T A C A C A T A T T A G A A TACATTTAACGATGTTGGGTCGT C C C C T A G A T C G T A C C C T C T A AA T C G G TGTCTTTAGCTT C T C T A C A G C C T C A G T AA T T G G T C C C A AGTAAAGTGAAATA A T G G C T C G T AA C A C C C T C G C T C T T C G GTTACGATAAAC C G T A CT C C C G T C T T C G T T G G T G T G A T GCCAGATGTAACA T C C G C A A T G A C T T GCC C A GC A A T C T A G T T A T CG C C GGACGCTGTTATTA C A C C T T C T T T A T C G A T CG T T G C G C G C TATGGTTGTTAA C G T A T T C C G T T TG A T A C A T A A C T A G C TTTAAGGTTAATAA C A G G T TT C C G G C G A T A C C A G T A G A A T GACATCGTTGTT CC T C A G C T C T C C T A G GA AG C C GA A C T A T A G T C C T AG T G TATTCGATTCGT T T A G T G A A T C G A T C C A A GG A T G C A C G TCCTCGAAGGTA A A C G A A A G G T T A GC A A C C C A G T T T G A AGTGTTAGATAA A A C A A T G TT C G C T C G G A C T A G C T T T T TTGGTAGGACAAGA A AC T T G C C A T T C C A TA A TG TT G A A C A T T C G G G C C AA CAGTTGGTAGTCCC T C T T C A G C C A C A C T T G G G GG T C G A G T TTAACACGGTAT T A G A A T A A T C T A T TT T T G C C A C C A C G AATATGAAATAACT A T C T G C A CG C G T G G A C C T T T T C T A A C ATAAGGATGAAT G G TT T A C G C C A G A G GT T C CTG C A A G C T C A C T G G A A GTTACGGAGGGGT A A C A T T A A A A C T A G A G G A A C AC C T C T GTTCTGAGTTAACG T A T C A T T A A G A C T T CA C A G G A T C C G C ATCGATTTTGGT T T G T G C G T C GC C C C G G T C G C A C G T A A ACCACGTGATTACT A T G TGAC A C C A T G G A T T A A T C C A A A G C CGTTGAGTCGTGTAAGCGGTCAT A G C C A T A T A G C A T G T G C T T C CG T C G C CATCGACGAATC T T A G A G T T A C G G A T C TG C T A G C T T T T GAACTAAGTGAC A G T A T C A A T A Tni G A G G C T A C G T G C T T C AAAGATTAAA C G G C C T Tot GCTCTTTGGCGCATTACAATCACGACAAGATGTCTGGTAATTATATGGATAAGGAA T GCGTTGTatnTeGCTG C C G C A T A C G A A A A T C G T G A T A A G C CAAiGTTGCTTGTCGCC C T C A C G C T A T A C G A T T A A C A T T GCCGCATTA T C G A A G A A G A A T A C A A G T G Tr T G G G G T G TAAACAAA C C A C T G C A T A A C T A C T Co G T T A T T C A A G GGGATCTA G A T G T T C A C T A T C A'3- TGTTTCCGTTGCGGTTCTGGAGACGACAGAGATGCTG G G T T C T C T C G CCAAGGTTA A G A C C T A T'5TGACGTTCTCGTTGTTAGTCATTTTGATGGCGTCTAGGTTTTTGAGAAA G T A C TCTCTACGATC CnieTcGA A C G C G T A G C C T T T G T A T A T G G G C G GGAGTnTTTGATGG G A A G G G A T C C A A G C T A G A A T G T T CeGuTCqGGCAAGATTATGAAT C G T C G T T T T G G T T G A A C A C G GCTTGACTC C G A G A T A A G T A A A G C C T AeTTTTGAACACCACGCAACGATTTTACCAGCCACTTCCCA C A A G C T T A C A T A A G GTCGACTTTGCTCATT T T A G A A A G G A GACTGAG T A C T T A A C AS T T G G G G G T T A G C T T T T C A ATTACACGAAACAGACTCCAAezislato)p 98Tb(61551OQNESDI4555PeMV P Vma LCG_MA5 LCG_A6NR R30 R R30C G G T T T A T A G T G C T T G A A A C C T T T A C C A A AATTCGGGACTTTGACTAATAT G T C A G C C C T C C A G A T TT G T T A T T G C A CGGACAAGACAATC A T C A C G T T C AT T T C C A A T T A T C C G G C AGTGAGGGGCATGA T G G AC A C T T A T A C C G AA T T A CCA T A A T C G T G C T A C G A TTAAGAAACTAGACT C T T C G G C T A C G T G C T G A T G CT A C T T G TTACTTTGTGGAGG A A A T T T T T C T A A G CG A T C T T A T C C C G TACGTAACATTTTA C A T T C A A AA A T G T G T T C C G T T G G A G A GCTACTACACCG T T AG A C A T A T T A C T T TC G C TT AG G C A A T G T C T C A A A AG AACATAAAATCGTT G C G G A G T C C C T T C T A A A A CA A C T A C C AATGAACGTAGGTT A G T T A A A T C A C A GA T A C T C C A A T A T A G CCCATTTCTAGA A C G C G C G TA C A T G C A A A T C G C A G G A C G GAACAGAGAATG C G CT T A T T T T A G A G A TT T A ACC G A G A G A A A T A C A T G GCTCAACTTGGTT A T G G C G T A C T T A C A A T A G A T A AA G A A A ACAATCTTCT G A G G C G A C T T A A A G G T T CC T A C C C G T T TGTTTCAGAGAT T A G T G G A T T T G A TA T A C A T A T T T T T A G GCAACGGAATCA A G T T A G A TA T A G A G C T C A T G A T T C T A A AGTAAATCAGTG G G CC A A A A G G A A A T G AA C G GCA C G G C A A A T T C A C T G ATCAAAACTTTAT C T G C G A C G T A G T G G T A C T A A A GC T A T T TCACACCTCAGG T T A C A T A T G T C C G G A A GA T A C C T T A A A GAATTAGTTACA T G T G A A G G A T G AT C A C T C C T A C T A A A A CAAATTCTAACA C T T G A A GT G A G T C T T C A A A T C A A T A G C TAGCGCATGAGT G AA T A G T C T T A A T G C GA A CA TA C A T G T C T T A G G T G TC AAATCTTCGCAT T T A A T G A G A C T G A A T A G G T T TA T A C T T TTGGCCTAACAT A A T A A G A T C T G T G A G GT C A T G T A T A C T ATGCGCATATAA A C T A C T C T T G AA T A C T A C G C A G T A G T G ACTATCCTTGTT T C C A A CT A A A T T A T G T T A G A A A A A A T T AAATTTACAAAA AA C A A G A G C A T A T G GG AT CA G C C G C C C A C T T A T AA GAAGGTATATAC T C A G A T A C A A G A A A A A G T T G AC A C T G A AAAAATCGAAAC C A C A A T G G C T T A A C T AG G C C T G T A G T C ACCGGATGAACG C T G A T A C A T A GT A A T T A C T A G A A G A C G ATATTCTTTTCT T G T C A TA C G G T A T C C A T A G G A T A T T T G ATACTACCGGTA CC G T T T C C T C C A G A G TG TG G CG A T C G C G T T T T A A TA G GTCCCTGGACAC A C A G G C A C A G G T T T G C A T A AA A G G G G A GAATAAAAAGAT T C A C T A T A A A A T C A CA C C A A G G A C T A A CTTCTGTAAACA T A C T T T T C A GC T A A G T A G T C T C G C A C T TTATTTAAAGTT C T A C GnG G A C T T A A A A C G C A C G A A C T T A CTACTACGAA Aoit G A C C G C G G C A T T A C C G A G A T C G T C C T AAGAAatGnCAeTACGTGC T T T T G C A A G C A A G A A A A C C G T C G GiTACTAACTGCTGAGAACTATAAGAT T G T G A T G T T G T A G C T G T C G GAATACTATGTTAATG C A G A C A A G T G T T T T G ACTTCCA T C T T T T T T C C A T A Ar A C C T C G T G A T C T A TAGGGAAATA T A A T G G T T A Go3 C G A A T A T A A T T G A A T A A ATAATATCCA T A C G A A'- T G C T T G T G G T A A A C G G A A T A C TGGTCCCACT G C'5 CCG A A A G T T T A G T A C A G C A T T T G T T G TACGAGATTCCCA G A C G C A A G T G G A T A T G G T C T T G A G AnieCcCGGACCTGCGCTTTCAT T A G A A T A C C G A G A T T T A G A G GCCATCTTTTT A T C C T T G G C T T T C A A T CnCeCGuGCCGTGCGCTTCCTTATGAAGACAACAGATAC A C T G G A A T T A T T CCAACCATTCT A C T A T A A G TqTTCAGGGTGGACCGATTGATCACAGACCGGTTCATGGGACCGCAAGATC C A C G GATCTTTCGTT GeT G T A A A T T T G T T A T G T A G T A A T A C C T GATTASGAACACCAAACTACTTTCATTTTGGACGTCCGGAAATTAACACACTCCGTTAACCTGTezislato)p53Tb(22OQNESDI65PeMV LCm_aGA7NR R30C A G T T G C C T A G C C C C A A T A C C A C C T T C C T TGAGTGTCCTGACTTCTCCTCC G T A C A A C T T A T T C A C AG A C C C G C T T G TTTACAACTTTG T C T T C T A C C T AT T G G G G A G C A C G G T A TTTTCTAACAACTA C C C A AC T G C A G C T C T C A A T C T T C C G T ACTTTTATACCAG C G T T T G A A A C A T T A GTG T C C CG G C T T C T A C C T AA G T G TGGGGCTCGTTTTT A A A A A A T A C C A C C C A AA G C G C G A G C C TGTATCTAGCGACT G C C T A C T T C AA A G T T G A T A G G G A C G T CTATTCTCTACC T C C C CTAC A A T G A C C T G T G A G T G G C A A CTCCCCTCCTATAATGAAACTCACG C T G A T G A A T T T A T C C C C T C C AA G C T C AACAGCTTTAATCA T T C G A C C A A C T G C C AA T A C T C A G C T C TTTGGGATTTTG C T G C T A T C C AT A G G T C G A C T T T A T A T TGATAGTCCCTACT C T A CC A T C T G C G A G C TT T A C AAC T A C C G T T T A C A A C C AAACAGTATCGACGA A G G C C T G C G G T T A C T C T T T TA C A G T C AACCGTATCCTT A A C T T T C T C A T C A C AG T A A A T T C C G C TCTCGGACGGGGAA T C T C T T C A GT A T A A C A C T G C T T G G C T GCCCTTAATCTACA T A GA G G A T G C T T C A C CT T T AT AT T A A A T A C C A C C A G GT ATGCACTACTCC A C G C T T T C C G A C C T C T T C T TA C G G G A TCCCCAATATCACC A C A A T T T A T A A C C CA T T T G G C G G G C C CACATGACTAACTA C C T C C T T GA G T T T G G A A G G T T G A T A C G ACCCCTTGTTTC C A TGAG T C C A A G C T A T T T A T G C A C T T A G ATCCCCCACCAGCGTTGTG C G T C A T C A A A G G A C A A C T C C T T AA G G C AGGGGTCGGCTA T G C C T A G A A C A T A T C A A TT T G G G A A T C GGAGTTTTTCCC C G C A C C T C C T T T CG A A T G C G G G A C C A T TCCTCTTGTC T T A C C A T C GG G A T G C C T T C A C A T G T A C TTTACATCGTAC C A T TGTA C T T T G C C A G T T G T A A T T A T C G CCTCCCTTCCACCGTTACCTA G A C G T C C G C T G C T T T T A C A A C C CC T A A TCTTGCGCTG G A A T C T T T G G A A C T C C A T AT C T T C C T G CACAAAGCCCCC A T A G G A C C A C C C A GG G T T C T T G G C G A A TGGCATATGT A T A T C C C C T AA T C C A C A T C C A G C T A G G CAGCTTCACATC A A T C CA G T G T T C T A C C A A T C T G A G T C C CTACCCTACT TG T T T A C C G A G C T G A CA GT A GC G C T A C T T T T A T C TG T TTATTTCGTGAC G G T A T G A T C G C T A G C A C T C GG T C T T T G GCCTCACCTGTC T T T C G C A C T T C C A T TT A G C T T G G A G C C TCTGGGGGAA G T C C T A C T C C GA T A T T T A A A G C T T A G A GATTAAATGTAT C T A T C TA T G A G C C G A C A A C C T T A T A C T CCTCTACCCCCC Cni A C T C C A G G G C C A C GT Aot GC A C A A T C C C A T T C A TtGAGCTC G C G G T C T C T G G G G T T T T C T T T A T C CanGeAA AGAGGTTGAG C C C A C G T T G T G C A A A C A T T C CiCAAAAATGTAACACCCTATTACTGGGAATCCGCC A A T G T T A C C C C T C C A C AGCCATTGAACATCCT C T G T C C T A C T C A CAAAGCG T C T A A C T A C C Gr T G C G C C T A G A G A A C G C TTCTACTACC C C C C C C Ao3 A G G G C C A A A C A A G C A C G T T A CCTCTTCCCC A T G'- A G A G T C T G C C G C T T G C A C T C T A A C TTACCACAT'5 AGT T A G G C G C A A G T T A T T G T G A C T T A C T T AGCACACTGTT G T G C C G C C A C C A G T C C C T C C A A GnieTcAAAGAGACCCCACAGGTCGAC C A T G C C A G T A C T T G T T C C TGGGGTCCTTT A A A G A C T A A A A C C C GnAeCGuAACTAAGTCTGGCGCCTTTTCTTTTACCTGCAC A A C A T C C C C T T AAATCGATTAC C T C C C A A CqATGATATCGCCTATGGACGCCGGGAGTACCGGTGGAACTACTAATCAATCC T C C ACACCCCTCTCeC G A A G C C T A A C T A T G C A A G T T T C T C C A ATCSGTAATACGAGCCACTGGAATCGGGAAGTACCCGTGGTCTCTGCATAAATATACCTCTCezislato)p75Tb(02OQNESDI75PeMV LCm_aGA8NR R30T G T G G T T G T A G T T A T C G T T T T C T C C T TGTCGAAACAGCCTTTTTTTTTAC C G G T T T A G T T G TG G T G A T T T G G C AGGGGGTTTGTTCG G T C G T CACA T A C T T A G T T T T A C A C GGGAGGAGGTTCTTTAAAATTGCGATC C G T G T T C G T C A T A C A A A TT C C G G TCCTCTTCCACAACTC G C C C C C A C A G TG A T A G T T T T A T T ATTACTATACGATT G C T T GA T A G T T T C G TA A T C G TCT T A A C C G T T G G A G A TATTCCTCCCTTACG T A T A C G G C G C G A T C G G TT G G G G A TTCATGTTGAAACGGG G A A T C C C T T TA A A G T C T C C A T T G TTTAGGAATCGAGT G C T TA C G A C C C C G T GT C C C TA AT G C G A T T A A T C G C TA TACGGCTTAGAT T A T A T G T C G G A A T T G C A AG A G A C C AAAAGATCGATGAA A G C T A T C A T T G GT T G C A A A G A A T T CTGCTGGAACCG C T T C C T TA C G T C C C G T T T T G A A A G GAGTTTCTTAACAC CA A A C G T A A C A C A TC CG G CG C C C A A T G T T C T GG A TATTTCCGTTTTCA A T G T T T G A C C T T G C C GA A G C A T A T TTCCTATAGCCT G A G A C T T T A A TG T A G C T C T A G T T G TTGAAGAACGGTAT T C T A CA A A A C A A T T T C A T C G A G C T GACTAACACGTCA C A C G A C A G C C A C C GAT G A C CA A A G T A T T A T CC T T T GTGAATTATACG G G G G T G G G T T T C C C GA C A G T A T T G TTCGTGAACTCACA A A C T T G G T TA T C A T G G G A A G A C T G GTCCTGTAGCGT G G G CT A G T A T G T T C AT T A G AAA C C A G A T G A T T T T T CGCCGGGCGATTA G T T T A C C G G G C T T T A C A C CA T T C A CAGTCCATCCTTAA G A T G G A T A G T T G GG T C C C T T A T G C ACTTTTGCGTAA C G T T A T G AG C G G C T C C G T T T G C A G CCCTAAGCTTTGTA A GG C G C G T C A A T T TA C TA TT T T G C G T G A A G G C GT TGCAGAGCCATATA G G G C C T C A T T T C A G G G TT C T G T T G AGTACAAGATCT T T G G A C C G T T G GT C C T G T A G C T A G AAATTCGACACTAC G T G T T GT C G G A A C A T C G A C G A A A A GGTAGCTGAGAT AT G A G C A A T G C A G C CG CC G A TT T G G G T A T A T T AT A T GGTAACAGATTA C G C G G T A G T T C T C G A TG C T G T A A C GCTTTTATGAATTC A G T G G T G T C TA A T T G A G C T C G G A C TACGTAGCATTG C T G C AGAC C A G A T A G T A A G T G C T G G AGAGGGACCACGGCGGTACGAGC C C T C A G G T T T A G A C C G G C T AnT A A G AAAGTAACTCCT T T G T A G A G C T G G T T Coit CATGTCGCCGACACGGTTTTATATAATGAAAT G A C A T G A T C T CCAATGAACGG C A C A C G GatnAeGGATACGGAAAGTACTTCTAACAGTCCTCGATCATCAGGGATATATG G G TTGTACGGGAiGAACCAA G A C A C T G G T T G C G G G G T G C T C Ar A T TTTGACTTCTGT T G T T C A T A A T A A A G T A Ao3 C A T A C C C TAAGTGTATT C C T C C G C C C G C G C'- T5 TGTAGTCAACCTGTTTGAGGTGAGAATGTTCCCC T T T A G G A A G A CGAAC A T C G G G C T G C' G A A T A A A C T A T T T T T T TTTTGCTG T G T C A A TiT T A T A A C T G T A C T A C G C C C TATCCT C C C T CneG C C C C G T T T T C T T T T T C G T T G TCGTAACA G CcTnCG G G A T C C A T T G C T T C T T G G T A G T TCTATGeCT G T T T A T T C G A G T A A C T G A G G G C G T TGTuTGqTATTTT A C G T T C G G T A C C A T G G T T C G C A T TCTAAAACA T C G G A T T G C A A A T C C T T C G T CeCCTTGTCAAATGATTGAC G T C A T T A A C C G G G C G T T T CGGTGAA G G T C C C A G T T G G T C G A AS A G C T T A A T C AAATCTAAAACACTCTTTGTAACTTAGTTACAATGCCezislato)p 306058Tb( 9 331OQNESDI859506P P PeMV CMV MVma L _A9 LC_A0 LC_A1NGRR30GRR40GRR40T C C C C C A A C A T C C T T C A G T T C G C G A G T T TGAGCAGTCCATCAATAAGCGA T C C C T G T A T A G G C T CT A A T C C G C C G TCCTTGGTGCGCAG G C T G A T G C GT C C C A A A A A T A C T G G G GGTATGGTTGTCAA G T TT G C C A C G A G A C CG T C TT TG G G T G T C A A C A G C C TT CACTCCCTCTGAGG G G T T A T G T C C C A T G G C C AT A C T G G A AAAGATTCAAGT T C G C C A G G C G T G G CT C G A G A C C A A A C GCTCCTCGGGGG A T G C G G T T AT T T G T T A A A T C C T T G C C AGTTACTTAGGT C C G TTTC C C C G T A C C T C C C G T G G G A G A ACGCCACGTTCTCGCGTCCAA G C G G T C G G G G C A A A A G A G G A C GT T A T CCGGACGGGGAT A T T G C A C A A G A A G A G G TT T G G G T G A T TCTGTGTTTCGT A T T G G C G C G C A TT C G G C G T A A G C C C A TTCTCCACGTCG G A C C A G AT T A T C G T G A G A C T C C G G G A GAAGGAGCATTG A TA A T A A G T A A G A C CT A CT AA G A A G A A G G G C C G C TG CATGGCCTTG A T C A A C T A G C T C G A T G G G G C AT G C A G CAGAAAGCGGTT C T G A G C C A G T G G G A G CA T A C A A G T G G TACGGCGCGTTA G T A G C T G G G A CC G G C G T A C T T A T T T G CCGAGGTGGGAC G A T A C GA G G G T T C T T G G C C T G C G A A A GTGGACGCTTGG AA T G A G G C C A T C C C AA GA G CG T A T G A A A T A C T C AG A CTTCGGACGTGC A G T C T A C G C A A A G A C A C T CA C G G G C A TAACAAGACCGC G C A G C T A A A C T G T GG G A T A T G C G C A C GTAGGAGCCGGA G G G C T C G T GT T C G C G T C G C A C A C A T G AGGACGAGAGGG T C C GGAG G C A T T C G T G T C C G G G G G C T G GAGCCAGATACCAGAGCATTA T A T A A C T G A T A A T G T G A A G T C TG G T C AAAACAAAGAGG T C A G C G G C T G A G A G C T GT T C T G A T G G GAAACCCGAGGT T A G T G A A C T C C AG C C T G A T T A G G C A C GACCAGGGTGTC T G G C C G AA G T T G A G G G A T C T G A T A G T ATGGATTATGTC A AA G C G T T G A T C T A AT G AGG T C A G T A G C A C G C A TGACCGGATGGGA G G C T C C G G C G T T C C G G G A T A AA C A A G TGGACGAGTACT A A A T G G A T A G G G T C G CT C C C G G A A T C ACTCGCTGGTCG T G G C G A A C T T GG G T A A A C G T A T C T G G CGTGAAGGGCCG C C A T T GG T C G A T G C C C G C C A G C T T T T GAGAGCGCGGTT GT T C A A C G A T G G C C AT TG G GA A G C G A T T G G G C C CT T TGACCCTAGGGT A T A C A G G A C G A A G G G A G A GC C C T C T A TGTTCTTTTTTA G G C T A A A G A G G T G GA T T G T A C C A A A C CTAAGTCGATCA T A G A T A C T GA C T A C C G C C A C A G C A A G CGGAGAGGCGAC C G A CnT G A T C T G G A G T C T G G C T T T G G C AGCCAGAGGToit TtTC C T G C A A G C T G T G G G C T G A T C C T C T TCGanATeTCCATTGTT T C A G C T G G G A T C A A T C G C T C G AiATAGCAATCATCTCCTCAGCGTTATCTA C C G T G G A G C G A T T C C T A CACGTGGAGGTTGTTC G C A A A A A T C G A C G CAGGAGCGT C G G A G C T T T T Tr A G T G G T C C G A C T G G G CTACTGAAAC C T C A T C Co3 G A T T C C A G A A A A A C G G C G A GCTGTCGCCA T A A'- C A G T C A T T G G C C A T C T T A C G C C T GTGCCGTGT'5 AGCTAG T C A C G G T T G C C A C A C G A C C T T G C C TGGCTTATTTG A A G G C G G G T C A T A A G G A T T G GnieAcTAGCCTACTTACTCCCCGTAGCT T T A A G G T C G C A G G A C T GGGAGTCTACG A G C G T T C A T C A A TnGeGTTTCATAGTTCTGATTGTCTTTACCAAGGGGACCTGCG C C G A C C G G CGGTTGCTGGG A C A A CuTqAT C C T A A T G C G C G A G A A C T G C GGGAATTCTT CeGT G C G T C T A G T G A A G C G G T A C A T G C CGAGGGTTCCG T G T A A A G T C A G G A A C G T G C G T G C T TS T T TTCTCTAGTATACGAGGAGAAGTCGCCGAGACGAGTTACGTGAGGGGTCCCCTezislato)p52Tb(01OQNESDI16PeMV LCm_aGA2NR R40A C A A T G C C T C C A T C T G C T T A G A T C CTCCAAACCGTCTTGCGGTCCGAGATCAAA G A C A G G AC C G C C C A G G A C A A G AAGGGGACACTTTGGCA G A C T C T A T C C C A TGC T G C T G TA G G T A A G T TT C A T C G CCTGTCGATTTATACG T T C T A A T CG C T C C A C G G G C T A ATTCCAGAGCGGAGGATTT T G C T A C G G T C A C CGC T A G C CG C T G A G A A GT T T G C TCCGTGACATCATGGTAG T G C C T T G AC T G T G A G C A G G G G CTGAGGGTGTCTTTT G CG A T T A A A T C G C TG G TT G C CT G A G A G A T C G A CT T T CGTAGCACTGGTCA G C A C A C G A G T G A CC G A G G A C A G CCCGTGGCTTCCAT A G T T T A G TG A T T A A G C A C A T G C T CGTGAGAGGGGC G A AG A G C G G A G C G TG A C CA CT C G T C A T G G A T A A CG TTTCAGGGAGGGTC A G A T G C T G G T T A T C G AA T T C A G T GTCTCACTTCGGAG G T T A T A T T A GT G T C C A C T T T A G A CTTGGGGCGAAT A A C A GAGG T T T A G C C G G A G A T A G T ACGTTCACTGGGTAGTAAAGTTA G T C T A G T T A G G G T T C T T G AA C T T CTTACACGCGACTG T A C G G A G T C T C A AT C C G A C T A T C AAGTCCCATACT G T A T C C C GT T G A C C G T C C T G A T T TCTGAAATCACGTT A AT C G A A T A C C C A AC C GT CC C C C T G T A C T C T GT AACCTAGTTGTTCC C T G A T G C C G A C A A C C AT C C C T T C TTAATGAATGTT T G G G C T T T T T AT C G C G C C G T C G T TGTTAGGACTATCG A C T A GT T T A A T G T A T A T C C T G A A TTTGATATCGGGT C A T G T T C C C G G G AGT C C T TC T A T T T A C G A AT G C C CTAGTTCCATTT T A T T G A G T T A C G C AT A A C C A G G C GCGCTCCCCACCTA T T A T G G C AT C C T G C C A T C G C C T T C CAGAAGTATTAA T A CC A C C G C A C T T TG C A CCT C C T G A A G T T A A C G CTTCGAAATCT A T C T C T A T A A G T A C T A C G G CT A G A CGGCCCTCACCA T A T G G A T A C C G G A A TC C T C A A A T C TGTATGTCGG A G A C T T T G C A TA T A T C C A C C C C G A TACCGGGCTAAG G G G T G CC C C C G T C T C T T G C T T G A T CGTGTAAACG A TG G A T T A T C C G A GT G TA GT T C G A T C T A A T C A AG TGAGGCACGC G T T A T A A A A T A T T G T G C G GT T C T C AATGTATCCCCA T C A C G G A C T G A T A GG C A C C A T C A C CCATGATAAT G G A T C G A C A TnA T T G G G G A C T A A T T CGAAGATAGA T T A C C Coit ATAGCAGAAGGAGTACGGCGTTCCGTCGTAAATGGATCTCCCGTATA C T TCTAGACGGatnAeGC G C T T T A G T G C G T A A G G A T T T C A TGGiGAACGGGCTCAGCT C C T C T A G T C T T A G T T C G C G AGTCCGCGG T A C T A C A A A A A T C G C A Gr A G C T G A T TTCCCCACGT T A C G A G C T T G C T Go3 A T G T A G T T G T C TGTCTGAG G T T A T T T A A T'- G5 GGAATGTCAAACGCTTCGTCTGTCAACGGAGGTAGGGGAGG C T C C A TCGACTT G C C T' G C G A T C G C A A A A A C C C G C G C GATGGCCGGCiA G A C T C G C C G C A TTneGG A G A A T A G T C C G CcATnGGACCAAGG A G G A C A A A C G A T C T A C T G A GeTAGCCCTGGGGCGAGCTAAAT T C A G C G G A C C A A C A C GCCGCTCTTGA G C G G A T A A G G A GuTqGTTTCTTTCTCGACCACGGTCACTCTGGGGTGCG T C C C A A A G AGGTAAAAGGT G G A T GeGSTCCGCGGGAGGGTCGTGGACAGTGTGTATGGCTGGATGAAGCTACCGCTTCGTGGGTTTTTCGCGTTAC G ATTGATACGGTGAezislato)p 4Tb(82930101563OQNESDI26364656P MV P P PeV V Vma LCG_MA34LCG_MA4 LCG_MA5 LCG_A6NR R 0 R R40 R R40 R R40G T T A T A A A A C A A G C T T A A A A T T A C C C G G A CCGCGAAGGAATCCGAGATGCCGT G T G C A C C G C A G C C G GT G G T G G G G G C G GCCAAACTTCAGAT T A A C T C T A TA T A G C T G T T T A A G G A G T C GCCCAGGCTATA G C A CCAC G A A T A T A A G C T A C T G T T T C G T CAGAATTGAGGCTTAGAAGTA C C A A T A A A G A G T T C C A C C G C G G TT C A C ATTGGCGTACCC T A A G C C G T C C C G A T G A G CC G C T A A T T A AGGGAAGGAACC A T C C G G T A G T A G GT T T C G T T A G A G C A A AACCGTTGTTCG G T C G G A T AC T T G G G G A G C A A G A C A A T G GGTGATTCCTAT C A GA T G T A G C A G G G C TG T C GGC T T T G G G T G T G A G C C GGACGGTCGTGGA A T G A C G C G G G T G T A G G G G G C G GT A G T A AACTAAGGGAAC A G T T A T G C C T T G A T G A TG T T G A C T A G T TATGATAGAGGA C G G T C T T G C T C CG T A T C G A G A G A A G G T GCCCCGTACACG C C G G A C CG C A C G A C G A A G G G A G T G G C T TGGGTATACTTCAT GA G C T A T C A C G G A A C TT GC T GG G T C C G A C T C C T C GC T AGGAGCCGAAGG A T G A T G A G A G G T T T T T A A T GG A G A G G T AGCATCAGGTCG T C A G A G C G T C C C T T AG T G C T G G A T G A T GTGTCGAGAAAA A G A C C G G C G GT C A C C G A A G G G C A A G A A AGGGTGTAATGG T A G G AG T G C C T C T T A A C C C A G G A T A C T TTGGGCGTTACCG A G A C A A C A G C G A G C GAA C T GG T T C C T A G T A T G AC C A AATGTTATTGCGTG G G A G T G A T A C A A A C C C T GA G T C A T G T A AGGAAAACCAAG A A T A G G C C G G C A GT A T T A T G C C A T A A G CAAACTGTCACA A T A T T T T TG G T T T G A C G A G G C G G G T G C GCAAATATGTTC G T TT A T A A A G G T G A G TA A A TGT A G C G C T T T A G T G C C AGCGGTGGGGGAG G C G C A T G G A A G T T A A C A C A C A GA G G G T CAGAAAGGGCAG A G G C A G C C G T G A G G T C AC G T T A C A G T G GAAGAACTTAGC A T G C G A G G T T A CC A T C A A G G A T A G G G C GAAGAACGGTCCTC T G T A C TC C A A A A C T C T G A G A T T C A T T G ATCGTACTAATA GA T A C A A C C G T T G A G AT AC G TG A G C G A C G G G C T A AC A TGGCGGTCAGGG G A A A A T A G T T A G C T G G A C G AT A T T A T G AAGCCTCGGGAA T G A G T A A T G T G G C A CG A C G C C A A A T G T GGAAGTATTTAA A C T A C A A A C AT A A C A T G C G T A T A A G G A TTTGAGGGATGC T C A A CC T C A G G G G G G G G A C T A G A C C A G TCTTCGAGAACTT A T A G T G G G T G G G T T AGC C G AA A T C A T A G T T C G AT G T CACAGACAAAAG T A A T C A G G T A C C T T C G G G GC G G G C T G A GACCGGTGATAA A T A T C T C A A T T T A AC G T A C G G G G A A A C CAGAGAACCTGC C T C A G C G T GnC T G T T T A G A G A C G G A G G T TACGACCAAC A G A G Toit CtACGTTGATTTAGGCGGTGAGGCGCCA A A T T T C G G AAGTCTGTTAACTa A A G A A G C G A G A C T T T GnTeGGiTGAGCAATCTG C T A A A A A C G A T A T G A G C G A T C C G GAGTGCTCGCAGAGGATAG A A G A G A A G T T A T T A T T A A GGGAGTGAA A A A G G C G T C C G C T C G Tr G C C A C C A A A G C AAGAAGATTT G T G G T T A G G C T Co3 G G T A G G G C A G C A A C C GGAATTTGTC G A T A T T C C'- TAACTGCTTCGTAGGACGATTTGTGACGAGAGCGGGCATATCGGGGATGACG A T A CAAGGGAAA T'5CGA T C T A A C C G T G A A A G G A C G T A A T A G TAGCCnieGCcGCACCGATCTAC A G A C C T G A A G T A G A A G G T A T T A AGCAGGACGGACG A G G G A T T T G T A C T C C C T GnGeTAuACCATGGCAACGCATCATGTGTGAGAAGTG C T T T A A G G C C T C T TCACACGATTT G G G A A C T A G GqCAGCTTAATTCTTGACGGGTGGGAGCTTACGGGTTGCATTACCTTCT T C C A A AGCCTTGACCG G AeG T C G C T T G A A T C G T T G A T T C T G C T C AACAATGSGGCCTAAATTTGCGCGCAAAAGTCGTTGGTACGTTTTTGTCTTCGATATCGTGACAGTezislato)p0Tb9(76OQNESDI66PeMV LCm_aGA7NR R40T C A G A G G C T G C A G G T G C C G G G A A G A T C T A A A AATATGGGGTGGGGACGGTC T T G G G T G A A G G C T G A C T C AG C C A G T G G G TTGTGCTGTGTG C A C G G T G T G A T T A CT C T A G C A A T G T T T G ACGGGCCAGATG A T C G T G T A CA C T A G G C A T T T G G T A A A C A AAGCAAGTGAAT T A A TCCT A G T A G C C G C G G T G A A G T G A A G G GCGTCCTGCCGTTCCCGACGG G C G G G A G C G G C A T G G C G G A A T A T GG G A C GACGAGTATTCT A A A A C G T A A A G G T A A T T A GG A A T G G C C A CGTCCGGGGGTA A T A G C A T G A A T T A AG T G G G T C G A G C C G A AAGAGATGGAAA A A G G A C T A GT T T A C G G G G T C C A A G A G T T CCACACCAGGAT T G C TTCT C A G G A T A A A G C G G G T A C A G C G G GTGTTTCAGATTGGGAAAATA A T A A T G A G G A T T G G A A A T G T G A T CC A C G GAAGACCTCGCT T G G A A C C G G T T T T C T T T C CC G A G A A G G C TGTGAAATGAAG G C T T C A A C C G C A T TG A A A T G T A T T C G G T CAGAGTCTCTAG A C G T G G A C TT C A G A A C C T G T G T A G A A C C CACATACAGTAA T A A GCAG A T C C T A G T C C G C A G A C C T G A A T CACCATCGTTGGTGTTGAGTG C T G G C A A A A G G C G G A A A G G G A C T TA A A G TTCGGTAGTGAG C A G A A G T T T C G A G G G A C T CC C G G A A T G C GACAGAGGTGGA T C A A G A C A G G A T T TC C A G T G G A T A T A T A TGGTCTACCACG T T A T G T A C TG A T T A A T G T C C C C G G T T A C GAGAAGAGGGTA T T T GTGG C C G A T T A T C G C G T A C T C G C C A G CTCTAGACGTCAGGATGTAGT C C G C A G G G A G A C C A A T A G G T T T A GC A T T ACGCGTCTGTTC G T A A A G C T T G A G T T C T C G TC A T T C G A T T GCCGAAGCGGAC T C T C G G G C A C T T T CC G G G G A G G T T G G T A CGAACTCTCTTT A T T A G A C T GT T A G T G A T T T A G T G C G G C C CGCCTCATTCCA T C T AGAC G T A C C T T C C T T A G A G C T A C T A G GCCCGGTTACGCTGGGTGTAA G C C T T G A C G A T T G G T T T G G C T T T AG T T A GGTGGCCCCGGG A A C A G G A T G C T A G T G T C T GA A C T A G A C G GCCCAACGGGGA G A C C C C A A C G G T T TT G T G G A A G G T G G A A CGAGGACTCCTC A A G G T T C T GC G G A G G C G C C G G A G G C G T G GACGAACGGTCC T C T AGAT G C G G C G A C A G A A C A G G G T A A G G GTTTACTATAACCCAAAGGGT C T A T G A A A A G A A G G G A T A A T T C A GG T A G AGAGTCCGCGTG C G G C T G C T G G C G G C T G C C AG C C G G C T G G CTGCCGTACGTT G G C C C T C A A C G G A AG G T T A A C T A C A G C C GGGTTTACCACC C A G C A T A T AA G A A C G C G A G T G C G G G A A T CACGTCAACCTT C T A CCCA T G G A A C A T G A G A A C G C G A T G A G GCTACTCCTCATCTTTAAGGA G C C C G A A C T A A A G A G T T A C G A C A TnT G C C GACTACCAAC G C A G A G G A A T G T T G A T C C T Goit TTGTCGGAAGAAGATCGGGAGTTTCCCGAA A G A T C C A T G A C A G C T TCCAGATAC A A G A C G C C T A T G AatnCeACGGGAGAGGGGGTGTGGTGTGACGGGGAGAGCGCACGCTGCG T T G A C A T A ATGTGGACGGA T T T A TiAAAGAAGAGGGTAGGTTGCTTGAGGAG G A T T G A A A A AGGTCTTTGAAAArA A C T G A C G G A A A G T C C GoG3 GAGGAAGT G G C G G A A A G C G C T T T G A T A G G T A C T'- G T A GCGTCTGCGT T T G A T G A A C A G G T A G C T G T G A5 A C A G G G G AGGGGCGG C T A G C C A G G C A T T G G T G G' CiCGGGGTGAGGCTACCGGAGTGTTATGGAGAGGG G T G T A A A A C A G T T TAGGGGTAAGA A C A C T C T T A TneT A A A A C C T G G A T A G G G T C ACGGGGTCAT A A C C A CcCnTGGACGAGGTGGTCGTAGGCTCGGAATGAAGGACGCTTCGTGGTGGTGCGGTACGTC A ACTGATTAeTuTTqTTGAAATGT G G G C T C A G G G G C C C C G G A G A G A G T AGACAGTCACC G G C A G G G G A T G A G A A G A G T C AeCGGAGTACCTTCTGATCCTGGGTGTGCG A T G G A C T T A C G G A A G A TGGGAGACA A A C G G A A A A C C C T AS T C C G G G T G A G C A A G ACCAACTTGCAGAGTCTAAGATAGAGAAGAAezislato)pTb(OQNESDIemaNA C T A T C C T T C A T T G T T G T G G G C A T A G C G C C G GTCAACTTTGTCCGGAACGT C A A C C T T T T A A A A G A T T T GT T C G T C A T A GATTTTCATACC A A G C A C G G G G C C C CG C A A T T C G A T A C G A TTAATCTTGAGG C G G A T G C A CG T A T T T A G A T G G G G G T A G T TACCCGAATGGG G C C GGAC A A T C C A A C G A A G G T C G T A C G A G GGATCTGTGTGGCTCTATTTA C C A G G A G A A A G T T G A G A A T A C T C TG T T T TACACTCAAGTT G A A G G G G C T G G C C G A G C T CA C A G A G C G A CCAGTCTGGAGA T G T T A C T T G C G C A CG T A G G T A A T C A T T A GGGTGAATGGAG G A G A C T C C CG T A A G C C G T T C T C A A G C A T TTATCACTCAAC G C G ATGT A A G A G T A C T T T C C T G A C A T A C T CCGAGGTACCCGTTATACTTC C C G C T T G C T A A A C T G C C C C A G C T CG T T C GTCGTCTGTTAT G A G C C T G A A A C G G A C A C C CA C T C T G G T G ATTATGAGATCT G A T A A C T A G A G T T GG G C C A T G A C C T G C G CGGGTCTGTTCA C C C G T T G G GA T A T C C A A C A T T C A T G A C T CGTTCCCAGAGC A A A GGGT T A A T C G C A A A A A C C A G T T G C G T GTGTACCGGTTGCATACCTAC A C A A A T T A C T C T A A T T T C T G A G T CA A C C ATATTTCCACTG G T G T C A A C G A C G C G G A G T AC C T T A G A T C CGGTAGATAACT C C A A G C T T T G A G C GT T C A A T G G C A T A C A ACATTTTCTACT C G C A T G A A AT C G A T G G G A G A A A G G G T T G GCCCCTCGGCGG A A C AATT T C A T G T C G C A G T G A T T T A T T A T TAGAGGTATTCACTAAACCGG T C C T A A G A T T T T A G T C C A A G G C C CC C T T TGTCGGGGACCC A T A C G T A A T A G C T C G G C C TT T G T A G A A G TCGAAGTAGCTG T C G T G T C T G A G A G TA C A G T A T C T C A T A A TTATTACTCTTG C A A A C T T G GG T A T A C G C A A C T C G G C T C C GTCGTGATTGGG C A T TGTT A C T G A C C A C C A T T G T G T A G G G A GTGCTTTCTTCCCCATGCGTT C G G G C A C T T T T T A A G T A A A A A A C TT T A C AAACCTTGATTG G A T T G C A C A T C C T C A A C G AC T T T T G C G C TTATCGTTACTG A A T A A T T A A G G T G TT G T T T G T T A T T G G A TATGAAGCACTG C T G A G A C G CT T A C T T C A T G T T A G C G A T A AGTGTTTAAACG A C T TAGC A C T C C C T G A A A T C A A C G A A C C T GAACCGTACTCATTACCTCCC G C A C C A C G C C A T G C C T C A T A G A G GG T C G AGAACACCGCGC G T A G A A T T T G T G T T G T C T AT C C A A C T T G GGAGGTCAAACG G G C G A A T A C A G C C CA T T A G T C T T A G A T C TTGTGGTTCAAT C C A T G A C C TG T C G G C T T C C T C C T T A T C A AGTTCTTAACTT C T A TATT T T T A G G G C A C C A C A T G A A G T T A CGGGGCTGGAAATTTTGATTC T G T C G A C A A G C G G C G C G G C G G C A AnC C C A ATGGTGGGAG G A T G A A G A T C T A A A T A T C G Goit AGTCCTCACCTCTCTAATATGGTCTTATGT T C T A T G C T C A A G C C G AGGATTTGC C T A G C C A C G T C A TatnGeGTCTTAATGTCTTGACCTAATATACAATCGCGCGTTTTGTTTA T C G C T C T G CTCACTCTGAA A T T G TiAGTCCTACTTACAAGACTTCTAATCTA C G G T C C G C T AAGAGCCCAACTGrC C T T T T C T A A A G A A T C AoT3 ATCTTGGC T C T C T A A T T C C C C T G C A A A T G C C C T'- G T C AGTCTGAGAC T G T A C A T C A T G G C T A A A T C A C5 G T C A G G A TGGTCGTA G A A G A T T T A C C A T A C T A C' AiCTCTTTATCAGCTTTCTTGCCGATAACAGCACT C T T G G C A G A C C G G CGCTTGAAGCA T G T G G T G T A GneG G C T C A T T C A T A T C T A A T TAATCCAAAT A A G G G TcTnTTTCTCTTACAGGTTCGGAGAGTTATAAGCAGAGAGGTCCCAACACGGGTACAAGAT T GGTCGTTCeCuTCqCGTATTCCT G A A T C A A C A G A C T T T G G G G C T G C A GTGTTTCCATC A A A T T A C G C C C A T A T G T A C C TeGTTGTTAAGATTCTCCAAGTACGCACAG G G A G C T G C C A G G C C G G CAAAATAAG T G A A G A G G G G T A T GS T G C A G T C A C A T A C A AGTACTATTAGTAACCAAAAAGACCCCAGTTezislato)pTb(OQNESDIemaNT A C A C C A T G A G G G A T T C A A A T G T T C C CTATCCGAATTTTGGGTGTGAT G C A T A A C C C G C C TC C G T G C C T T C GGAACCGATTTTCG A C C A T C TG T G G A G T A G C A C A A A A GACATAGCCGGTTT CG C T T C T G T A G C C TT CT G CA T T C G A C C G A T C TC T CACGTTTGTCGG A C G C A G T G T T A G A A A C TC C T T T A C GAACATCACTTA A G T G A T T A G G T TT C A A A C C G T A C T CTCTTTACGATT A T A G T T AT T A T A A A A T A C G G T G A G CAAATGTCTTTT G TC T A G G T T G A A C AC A CT TT C T A A G T T G T G G C CG GAAACATTCACA T T T A T A G A C A A A T C A T C AC T A G T G CTTTAATGTCCT A T A C T G G T G C C T AT C T T G T A A C T A AACTTAGTATAG A T A G A G G TT A T A T T A G A C T C A C A T ATAGTGTTCCAC G G CC C G C T A C T G C AT T A CTA T C T A A T T C G G T C A TCGGGAAATGTCA G T C C A T T T A A A A G A T A C C AC G T A A TTTTAAGATA A C T T A T C A G T C A T C CC G T A G A C T A GACCCGTTGTAC G C C T G A G C T CA A C A G C C C A A A G T G ACTTCGATGGTG A G T T TA C A A G C C A C T C T A T A C T T G CTATTACCGCTCT C G G T G C A A T A T T TAG G A AG A G A A A A A C T C CG A C GGAAGGAACCCA G C C C T A A A A A A G C C C TT A T T C A A A CGAGACCTAAAG T G C G T T A G T T CT G G C T C T G T G G G C GTACTTCTCTGT A G A T A TC A A T A G G G C T T A C T C A A G AGTGTAGGGTCC CT A G C C G A G G A G A GA AG C GT A T T T C G C G A A A AT C TTCGAGATAAGA G A C A T C T A G G A C T T A T GT G T C C C T ATAGTACGAGAC C T C A T G A C T A C TC A T C T T T C T G C A CGGAATACCGTC T T C C G C GC C T A A G T G C T G A G A G T T TGGAGAAGGTCA T TG C A T C A A G A T T GC T CG CG A T A T C A A A A T T A CA CGATTGAAATTT G C T A G C G T T T G C T G G C A TG G T A C A GCAGTCTTTC A A T A T A T C G T G A G TA A A C G T T G T C CGACTGGAAATT T A A G C A A T GC A C T G A T T G C T A G C T CAGCCCTCGTTT C C C GCGT A G T C A C T T C G A T A C A G C A CTTCGACTTTCTTCAGTGCAG T G G C G G A T C C G G C G A C A C T CC C A T GGGTGGGTAGAT T A T A A T A A T C A A C C CT C A G A T A G C GCTTCATAGAAA T T T G G C G C T TC T T G T C T T T A T T A T TAAATCAGTTCG T A A C GC T C G A G G A T G C T C T A C T A A ATCCCTTGTCCTC T A T C G G G A T C C G CCT T A CT A A G T C T A A C C Tni T T T CCTGCTGGAA A C C G A A A A T G A G C G T T Cot G A A A A T G GAACCGCACG A A A A T A C G C G C T GtG G G G A C A G C G T GTCACCCA A T T T G A G G T CanT A T T T G G T G G T A G T TAAGTAACTT A A T A C CeCiCTTTTGTATAGATTCTCACTCAAGGCCGTAAACCTTTGACCAACGCGGC T TACCTACCrCGAGTAA A A A C C C C C C A C A A T A G G A A G C Go A G TTCAATCGTC C A C A T A A A A T C T A G G G A T'3- GTGAACGAACCGGAGGTTGGTTTGAC C C C T C A G G T T T A C TCCGGAAAG T T T T A C T G C A C'5CACTGACCCCACGAGAGTAGTTACGTATCCGAGATAATCG A C G A C A AGATACGTGGT C C AnieAcTC T A A C C A A G A A C T G G A A A G G AGACTCTTCnGTTAGA G C C G T G C C C T G A T C G A T C C G C TeGuCCqCAAGGCTAACTGTGAT G T A C T A A A A G A T G G T A T TTAATATCAGG A G T A C T T T A C C A C TeGTGCGTACACTACATCATATGTAGGCTAAAGGGCGGTGTTTCCCTA A T C C C A T G C ATGTATAACTTAATTG G T T A T GGGGTGCTC C C AS A G G T G C T G T T G G A C A G C T A T A C TGGTCAGTGezislato)p 6109Tb( 501OQNESDI7686P PeMV C V _MCmL L _aGA84 GA9NR R 0 R R40C C T A A G A A T G T C C C G A C C G T T A G T C TCACGGATTGCACAACCACCGACGTT G G G C A A T G G CT A A G T A C C G C G A ACCAGATTGTTACT T G G GA T G T A C A T G TT C T A TCA G T C A G T A A T A C A C TCCTATCCCTATG T A G T C A C G T G A A C T T T A AA T T C C GGACTTCTGCTTCG C G A A T T C T T A A TC C C G C C T G A A T GAACATTAAAATAT T A T A G CG G G G T T A T C C T A G C T A A TGAGATTTAGAACTA T T G C C C A T A G G A GAT T C TG G G A C A G C A G CC T C CTCCTAAAGCCGAA G G T G A A T A A G A A G CT A C C G A G T C CATGTTACTGATAG A T G T G C C GC C C G A C T A T C A C G A A TTCTAGTTGGATCA G AT A A T C C A A A T A CA A GT TG G A T C A A A A A G C AC TCTCTCATTTCGTT G A G A G A A T T T C T G T A CC C G T G T C TTAATCGTCGGGTG T T C G G C A T G GC G C T A G C G C C A A G GAAGATCGAGATCT C G A GCTT A C T T A T T C G C A G C A C T G GGTTATAGGGAGTACTGACATAA A G G T C G A T A C A T C C A A G CT T G C A TATCAAAGACTACA G G T A A A A A T T T TC C G G C C G C C G G TGTGGTCCTCTCAT A C C A G GC T A T T C T A C A A G T G C G C AACCCCCTCGAA AC A C A T A C T C G C T TA AC C TG T C T C T T C A C T G AT C TGGCCCCATTAT G T G C G A C C C G A G T G G A AC G T T T T A CTGGTCTTGTTG G T C T A A T C G G G TC A C C T C T T T C C T CACAGTCAGG G A T C T G G AC G C T G T T G C A G G G G A G TGAAAATTTTCT T G CT A C C A G C G T G TT G A GCT T G A G C C G G A A C A G GCCGCAAACTTTC T C A T G T G G G C C T T G C C T T GT G G G T TCTTATCGAT T T A A T T T A G A A A A G TT G A T T G T A T GTGTCACCAGTC T T A T A C A A G CA A C C C T C G T T T T A C CTCAATTAGACA C A G A GC C T C C C T G C C T T T G G T A G A TTTCCACTGCCGC T T A T T T T C T A A T GGC G CA C T T T A A A A A C CC A TAATCCTTACCA T A T C G G A A T T A G A A T C TT A G A T T G AGAACCGGTGTA A G C C C T A G A G C CG A G A C A C G T T A G TCAAGGTGTTAG A G G G G A GA A G A C C T T A C A T A G A C C TTGATAGTCG G C AA T A T C C A C C T AG T T CCG T A A G A T G A A T T A G ACACAGCGTCCCT C T C C A C C G T C T A T G C G C G CC G A A T GGTGGCTCAAAA T G A G A T C T A A G T G TT G G A T C T A C G AAAACGGGAA A A C T C G T G A CC G G C A C T A T A G G C C CAATCAACTCTG T C A C CnT T G T C C T T G G A A G G C G A A T AGATTCACGT Coit T C G C G C C A A A C G A G C A C C A A G G A GGGGGatCnTGeTGTGGC T T T A C C A G G G G G G A T T T T A A G CACTTCCTTCC A A A T A A C G A T C T C C A G G TiGACTGGTTGCTCGGTTTTCCGCAGAA C G T G C A G T A C T G T CGCCGGCGA G C A G A A G T T C Tr C C G A C T T C T A A A G GTCTTTCA G C A G T T C To T G T C A C T C C C A T A G A A CCAACTCAGA T T T G'3- C'5 GAGCGGGCCTATATTGCCGAAGTGCTGTGGTCCACCTCCAACGTCCACAGGGTATGGTC iTA A C T T C A G A A G G G A G G A A T T A C T T G TneACcGTGGTCC T T T A T A A A G C T A A A T A A C T T A TnTGGGGGGAACCTGTTC A T T G A G C G C T A G G C T C A C CTTTGTAGA T A G G G C A A T A C T C G G GeTuGGqGATTGGCTAGTATAGTAATTCAGA A A C G T G G C T A A A T TGTAAGCTA T T A T A T G G T G TeCCACGGGCTTCTTCCCTGCTAAATCTAGCGGAGGCAGGGGGCTTCTGAATCATC A T G A A A G TCTCACAGATTTT C C A G ATGTC G G G CS C C C C T G T C A A A A G C G C A A A T A CGGTGTATAATezislato)p 772Tb( 769OQNESDI9607P PeMV C V _MCmL L _aGA05 GA1NR R 0 R R50G A T T C C C T T C G C G T T C C C T A G A T T G G G T G GGGGACCTGTCCCTTGATTA G G G C G G T C G A G C A A G T CA A T G G C C T A CCTACTAGGCCG A C A G T G C G C C G GG G T C G G C G C C C T C G CACACGCGTACG A T G C T G TG G T C A A G A C C C T A T T C C C A CGGTCGTGGGGG A TC A T A G C A C C C G C TG T AC CC G C T C T C T C A A T G A TT ATTCATGCCGGT C A C T G C T C T C T A G C A C A T T CT G T C G C TCGTTCCCGACTGT C T T G G C G T C C C C G TC T C T G T C G G C T C TCGGGGGCCGAT A A C T C C T G AC G C C T T A T T C C C T T G T C ACCCTGGGACTC C G T CTGG G T A G T A C T C G T C G C C C T C T T TCAGAACTCCGAAGGCTCCATCG C T G C T T T A T G T T C G C T T T T A AG G A C A CATCTTCAGTCG C C G A T C G C T C T T T G C GG T C A A C T C C G TTCTTCCTGCCT C T A G C C A G G T AT C C G A C G T T T T T T A G AGTCGCGCCGGC C C G A C CT T T G G T T A C C A G C T G C T G G C ATCAGTAGGCCCGGT C C A T C C C T T G T A C TGA G G CA T A A C C T G A G G G GA G G ACACTGTCTGGG T G T G G T T T C C C C T A G C A AA T T G A T C G TCAGACCCTTCG T A C G C T C T C C A C CT T C A G T C T C C C A T CGGTAAGCCACTTC G T C C A G TC T T A T C T T C A G G T C G G A A T CGAGTACGTGAG A GT C C G G G T G G G G T TA G AG CC G G C C T C T G G A G G T AT TTCGGGGGGCTT T G T T C T A G G G C G A T A T C T C AC A C T A T ACTACGGAACATTC G G G A T G T A G T T C T AT G G G A A C A C T C G TCCGATCACACG T A G A C T G C TC T A A G C G G G T G A A G G C C TGACTACAACCG A A G ACCT C T C C A G T T C C G T A G C C C C T T TTGAGGGTGCGATCCCAGCCAAG G G G A A A T G G C C T G C T T G A A T GC C C A A CGGAAAAGTCTT C T A A T T G T T A T A C A C GC T G C A C T G T C CACGTTCGTCGC G T C C C C C C T C TC C T G T C C G A C G A T G C GCCTGGGCCCAC T G C A C CC C C A T T G G C C T C C G C T C G A C CTTCTTCCGGTAAGC T G G T C G A G A C T G A GGT C T TC C G T T T T C T G A G GT C C ATTCGACCCTCC C C A T G C G T G C G C C T A C G CT T T G A C C C TCGAATCACACG G T G T A T A A C G A G TG C G T T C C G G G C A T AATTGCCTTCGG C C C T C G A CC G G C T T T T A A C C C C C G A T GACATGAACACT G C GC G A G G C G G C G T GC G T ACA A C A C C A C T G A C A G C TTTCAAGGACCTA G T T A A C C T C C T G G T G A C T T C GA C G A T GCATACCTCCACTC G A G G T A A G A G C T C T GT T A A C T C T G T A TCATTATTGTCC C A A T G T G T G AA C A A C C A G G G C G T T C G TCCTCACCCGGA A G C T GT C C C A C C A T G C A T A G G C T T A A GCTCAATGATTGni T C C T T G T C C A G C C C TTot T C CA G T C A C T C C C T C GtC T GTCTCTAC G C A G C A G G G G A T A C C G C T A G AanCeTC T C C ACCTCTGCCT C C C G A G C A G C T G C C C G GiTTGCTTTCACCTGAGCTCCGCATACCGTTACCGAAAACCGTTT C G A C G T C G C G C A GTAACGCAGTTGCGTCCGA C T T A A C C GTCTCCTCC G C T C Gr A C G C T G A A T T T A T A A C G A C T C GCTTTCCTGA Co3 C C T C A G G A A T A C TG G'- CC G G G T G G C A T G C G A ATACCCTTC A T T A G G A T G A G C A T T C C A A T T A C T'5CGCCCCACCGCTGCTTC A T T C A T A G T T A G G T C T G T A G CTAGGGGAC A G T G C A T A T A G C T T C C G TnieAcATCCGACCCCCACGGACACCTCCTATCT A C C C C T C G C C C G A G TGACCGACCTG C A C G C C C T G A CnAeCCCGGGGCATCCCATTGAGGTTTTAACGGTCTGAGTACCCAC G A A A C T C GGTCACCCG C A G G TuTqCTCACGTCCTTTTCGTTACAAAGCAACTGCGCGCCTAGTCCAGGGTGCAGCGTG G TGACTGTAeCTCCG T C C C T T T T A C G G T T T C G A C C G A C T G CS G AACCCTCCACTGATCTCCCCGACTAGGCTCACCCCAACAAGGCGTCGGTGGTGATezislato)p75Tb(02OQNESDI17PeMV LCm_aGA2NR R50A T C T A C G G G C T C T G T C T G T T G C C C G T C C A TAACAGTTAGTCGAGATAAGTTAC T G T G T C C T G C T T C T GG T G C A G A G C A G TTACTTCTTTCATT T G T G C C T G AG T A G A A G T A C T A T C T G T GACTAGTCTTCGGCTG T CG A T G G C G C G G G T G TG T CA G TC T T T G G G C A A G A A CG A TAAGTCCTCAGG G G T G A G T A T C T G A T C G T C C CA G A C A A T CAGGATGACTGC T G T G T G G G G G T G C T AC G G G A G T C T C T A TTCGTTGGTTACTT T T T C A G C G GA A G G G A C G C A G T C T G T C T GGTTCGACTACT G C T TCTA T T G A G G T A G G T G T C T G T C T C C CGGGTGGTGGTGTATGTTAGT T G C T A T G T G T C T G T T T T A G G G T CG G A T GTATTGTCAGTGCG T G G C T C T C G C G A C T G C AG G A C G A A C A A CTCATTGCCTGG T G T T G T G C G A A CG T A T T T C G A G C T A T A TTGCTTGATCCACA A C G A C TT T G A C T A G G A A G T G C A T G T G A TCGCCGAGAAGC TT A T T C G T G G C C T A C GC CT T A GT A T C T T C T C G C T T CT C A GGGGGTCTCTCC C G T C T G T G T C G T C G G A T C GA G A G G G G T CACGGTGGTCAC C C T C T T A T T A C T C TA A A T G A T C C C T G C TTGCTTGGTTGC C G C T C C C T CG G G C A G T C C T C G T G T C T G TTGTGTGTGCTACA G C CT T A C A C A A G G C T GC T G TGT G T C T G T A A T G C T C A CACCCTCTACTCTCC G G C C T G C A C C T G A G G T A G C G CG T C T T C TCGAACGCGTCG T G C C T C T C G T G G G G T TT A A G C T A G C T C ATAGTTCGTTGCTT G G T G G T G A C GA G G T G C C G T A A T T A T G T GCTTGTCCGTCG C A C C GC T G G A C C G A G G C C T C C G T A T T G TACTCGCGCCGGG C G C G C G T C A A G T G T GTC C T GT G C C C A C C T G A A CG G G AACGTAGCACTCGG T A T G T G T G T T C T T A G C C CT C C A A A A T G TTCCTTGACTGC T G T A G C C G C G C T TG C G G C C C G A A C A T C TTACTTCGTTGTAC T A G G C C CG T A T A C G G G G T G T T G T C T G T TGTATGTTCAGG G CA G A C A T G G T G A G T GT G GC T AT G T A T C G T G C A T C T GG C GCAAAGAGATTG T G T G T C T G T C T T G T G G G C A TG A A G G G C TTAACGTCGTGG T C T C T G C T C A G C C A CG G G T A G T C C A G T TTGTTTGATCCA T T C T G C C T T TG C T G A G G G C G T G G T G T G TTGGCTGTCCTGTC G G T CACC T C G G A G A A G C T C T A T G T G T G A GGTAAGGGTCTTCATTGAGGT A G A G A G C T C C G T C T G G C T G G T T CG G T C AGAAAAAGGACA G T G T G T G T C T T G C G G C C GT T C C G A T T G GACGGCTTGCTTCC T G T G T T A T G C T GG G G G T G A C T T C G G T G TCAGTTACTTCT G C T A C G TC G G G G C C A G A G T T C T C C C C G TGATGTGCTCGC C GA A T G T G G T A T A C G TT T Tni AG T G T G T C G T T T T C T Cot ACGAGGCATGGG T G A G G T C T G T C T G T G C A C G A A AtC A G C G GGTACGGG G A C T C T C T C T G C T C C A G C AanGeAA A T A T C A AACTCGGTGGTT G T G T G T C A G G G T T TiCGTTGCACGGCACCCGGAGCGACCACACGCTGATTGGGCATTTGGGGTTTTGAGC T C G T A C G A T CCTTGGCTTTGCATGGTTG C T C T CGTGCTCTC G Cr A G G C A G C A G C C A GG A GoA A C G T G T G T T G G C G C G'3 A- TGTGACGCTCC G T C G A C A T G T C T G T C T T C G A A G A TTGAGCCGTGG C G G C T A T C T G C G T A T G A G G C'5ATCGCTTAGTGGAGTCCGCAGGGGGGGT C C G T C T C T T C G T C T G ATTTTACTTGCTT C T C T T C C C A G GnieTcGGTGTAATCGGCCCGAAACAGAAGTTGCTTCGCTTTCCGTTCGCT C T C A G G GTTTGAGTTGGGG A AnCeCC C T G T A T A A G A G T A T G T C T G T C C T TGGCCGTuGTqTGTTCGT T G G T C G C T G C C T C T G T T T T G C T G TeCGCAACAGGTATACTATAACCGGTG G G A C T G T G G C T A T C G A C A A CACACAAGCGCCCCTTCAT T A T G T C T T T T G G C C CTTCGTTAC T C T G T A G G G T G GS C T C T C G T G A A C A A T G TTCGTTGCTTCTCGTTGTCCTGGTCAAezislato)p1Tb5 5(0532OQNESDI2737P V PeM MVma LCG_CA3 LG_A4NR R50 R R50T T C A A C A G A G G C G T C G T C C G C A G T T GCGTTTTGCTTACTTGATTA T T C C G T T T G A T G GG G A C T C T A G AGACCCAGGGAT G G C T G A G AG A G T C G T G A T C G G T CGTGTGTCCTTA A G AT C T T A T T T A CA T G ATC T C G C C G C G C A T T ACCCGAATGTCCA G G T G T A A A C C T A A C A T TT G A G C CGTGTGTACTAC T T G A C G G T T T T AT C C T C T C A C C GACGGGTAGTGGAA T G A C T CG T T T G C T C G G T A A G T T GCGGTGTATAGA GG G T T T A C C A A C GG GG T GA G T G G A G T A T T GT C GTTCTCCAGTGG G G T A G T T G A A A A G G TC T G A A T G AGTACACATACACG G A A C A T T T CC C C A C G A C G G G A A GAGGTCGGATGT T T C GTGG C T C A G C T G G G G G G G T A ACCGGAAGTGGTGTCTTGGAA G G G G C A G G A A C A G G T A G CG T C G AGCACTTTTACCGC A A C C G A T G G A A TT T C T C C T C T T CTTGTTCCCACT A A T A A T CC G A C T C T C G G C G G A G GAGAAGGTTTCA T GG A C C C A G C T A AA A AG GA A C A G T C T G G A A TG GCTGTCATGGTGTA A C A T A G G T A G A G A G GT C C A G A A CGTAAACCTTGC C T G C T C G C G TT A C C T A T A C T C C TGATCCGGAGCA G G G A TC G A C C G A C T A C T A A G A G AAGTGTAGTTAGA A A A C T C G T C A A A ATG G C C TT T G C G T A C C TT C G C CTCCGAGGTGGT T G T T T G A G G A A G GC C T G A A G A C GTCCATCATAAA T C T C C G G TA T C T A A A C C T C G T A GAACTTGGGCCT A G TC T A G G A C T C C CT C T GT TT A G A A A T A G T T C TA TCTTACTAGCTA G G T G A T G A A C C A G C G TC T C C C T CCCGAGGACGAC T G C T T C A G T T TA T G G T T T T A C G AGTTCACACTAC G C G C C TC T A G G C A G C T T G C C G T GAGAACTGTCAGGCT T C A G T C T A C T GT TA TC C G A T A A A A C A T CC TTCCATCCTC C C G T T T C A A T G G C G T G G TC T T T G TCTCGCCAGC C T T A A A C G C C T C A TC T A T G A C G T GTTCGACTTCTA G G T T G T A T CT T G A A G C A A G G T G G GACGAAGCTG T T C T GT T T G C G C C G A A C G G G A G A CTCAACGGGT TC T G G C G T C G G G TT TT CC T A T G C C C A T A T TT TTGGTGGTTTCG G T T T A A G T G A C G C C A G AC C G C T C TAGAGCGTTT C A G T T G T A T A A T CG T T G T T A T A T TCGAGACGTC G T T G A T G C Ani A C G A T T A T C T G A G C TTAGAGGG T C A G C Tot CTTCAGTGTAGGGGTACCAGTATGGTCCTCACGTGATTCATCTGGTAG G TAGTTCCatnTeTT T A C G G C C G C T A G A T C C C A T G G TGTiACCTGCAGCTC A G T G A A G T A C C G C G A A A T T TCGTGGTCA T T T G C A G A G G A G C C A G Ar A T T A T G TGTGACTC G C G A G A A T T C C A A To C C C T T T C C A TTCGGC C G C G G T T A T C A C C'3- CATCGACCTGCGCTGGCTCTTTTGCGTATT C G G C T A G A G G TTTTCTG A T T A G A G A A'5CTTCCTGAGGTGTTGAGTCGCGCTGACTGTAGAACCTC A A A A T C CCACCTG A A A C CnieGcCTGCTCTGCAATGCAGGCATTAAAACTCCTGACATGTAGCTTCAT G A GCGTTTGGAnCeTA A C A A G C G T T G A T T T A C C G G T A G CGAuCGqAGG C G C G G G G A G G T T C A G A A G T A C T CeCATCTGGTATA C T A A A C G G A T C C A C T C C A G T GGTGCACTTTCCC C G A G G A A G G C C T A T A A A GTCCT G T T T G C T G C G T A C T C A GS T C G T G C T CCGAGTCAACGGATTACGTCTTGCTCGTTGTCCCGACezislato)p75Tb(01OQNESDI47PeMV Cma L _ 5NGRAR50C G A C A A T T A T A A A A T A T T C G A G A A G T T AAACAAACACGAAGGAATAT A C A A A C G G A A G C A T AC G G A G G G G A TCCGGCTTTATT C T G A A C G C C CT T A G G G G G G C T T G T TCGCGAGTTGAAAC G G C ACGG G T T A T A A T T C C A T G A G A A GACGGTTTCTTAAGTCGATTCCC G G A A G C A T G C A T A G C T G A CC T T C C GTCGGGTCCCTT C T C T A A A G G G A A A GT C C A A G T A A G ACCGGTTTAAGCAG A T A A A A T TT A C T G G C C A A A C T C G G TGGATTGCTCAA G A TC G T A T G C C A G AC G G AGC A A A A A G T T G A T A G TGGTGTCAGGGAT C C A C T T A C A T A C C A A T A T CG A G G G CAACGAGCGAAGAT C A T G G C G A C C A A TA C G G T A G G A G A CAGTCGTGAAGG G T C G A G G AC C A G T C G A T G A G A C A G AGGTGAAAAAGAGA G CT G T T C T T C T A A TA T CG TA T C A A G A T A A T A C GG CGCTGTCCCACAAT C C A G A C T C C G T G G G T C AA T T G T T T GATTGTCCTAAA T C T A C A A A A T T GG G T G T A C G A A T C ATTCCTTCAGGC A A C C A T AA T C G G T G G A A T C A T T T C GTCTAAGCTGTT C CC A C T T G G A G A G C AT T GA A TC G G A C T G G G A A T GC C CTTCCTCTAAAA A A T T C C A A A C A T T C A T GT G C T C T G CGATAGCACTTGTC T C A C C C A G T A AG A T C G C G A C C A C A ACAGATGAACTA T A T A T CT T T A G C G T C G T T C G C A A T TTATCTAGAACTTTA T A G T A A T A G C C C TGC A T AC C A A T C T A C A T AC G C GCGTAGATTAGG G C G C C A C T A C A A T A T AA T G A G A A G TTCTGTAATCGC T T A G G G T G A G AA T T G A T A G G G G C A ACTTTAAAGGAAAG A A T A AC A T G T C C T G G A C T A C C A G A AGTACACTTCATC G T A T G A A A G C A A A TAT T A T GT A C A G C G A T T CC G T A ATGGACTACCTC C A G C C G T A G T A C C T GT T G A A T A G T CTTAAATTTTTAGA T T T G G A T T GG C T G A G A A C G T A C C A AAGGAAGATATC G T A GTCG A A A G G G C A A A T T C A A A A T CACGGCGTATCCTGTCGAAGG A T T G T C G C A T T A A G C G G T G GC A G A AAGAGGGGTTCCGT G A T A A G A T C T T C T GC G T G C G A A C A TATTGAGCTAGT A C T C T A G T GT A A T C G G G A A G A T A T GTTCCGTGTCGTAT G T CA A C G G G A G C G TA A C TTC C G T A T G A T G A G C G CTAGACGTACGAGAC A A A T T C T G T G G T T C T A G GT A C A C A GTCGAGACACGC A A C G A A T C C T C C AC A G C G T T C C C T AGTCTCCCATAC G C G G T T T Gni T T T G A T A G C A A C C T T T GTAGGTTGAT A G A Tot C G T T A A G G C A A A A T T T G A T T ACCTATCCGAAatAnTAeTCA A A G A G G G A C G C A A A T C T C T G C T ATCCCCAGGGTAA T G A C T C T C A T T T G A A C A GiTCCAGTGGGAAAAAACAGACCTTT TCT C G A T C A C T T G C G T GCTTGGAAC T G A G A C A G C T Ar A C A G C C A A G A C A G T ATCTCTTG T G T G T C G Co A C T A C C A C T A T G C C A A C CAGCAAAG G C C G G'3- G'5 TTGCGTTCCCCGCACGGGTTTCAGCTAGACACACTTAGAGCCTGGGGGAGC A GTACAGGT iTAAA T C A G G T T G C T T C T C T G C G T C G C G AneGcACCATGTTGGG T C T T C A T G C C A T C G T C C C A AnGCGGTAATAAACAGATCGGA T A A T T T C A A A G G A T A C TTGTTACCA G C T A T G A A T C C G C T TeTuGTqGCGGAGCTAACATGCGAGCATTTTGGTA C T T A A T C G G T C T CCGGTACCT G C G T T T C G A TeACGCGTAAAATATGGGCGTGTAGAGGTATCTCCCGCATGTGTTACACTGCGGTTTT A T A T A A A TCAATCCTGGGTT G G A T CTTGA G G G GS T T G G A A T G A C G C G G C A T G T T A A ATCGGACTCTTezislato)p 667Tb(4711OQNESDI5767P PeMV C V _MCmL L _aGA65 GA7NR R 0 R R50C G T T C G C T A C T T C T G C T A T G C A A A G C G T C AAGCTCGTGAGGAAGGGCTA T G T G G C C T A G A C T A T A CC T C T T T C A A CGCCTACACAGA G A C C G A T T C C A GG G G C A C C G C A C T C T AGTGAGAACCGA A A A C T A TG C C A A C C G T C T T C C T G C A T AGAACGAAACAA T TG A G G G T T G T G C T CC T AC CT C A C G A T G T T A A C C TG ACGAGGTCTAAA A T G A T A C A T T G T C C G A G T C CG G T G C A ATATCCACGCTCTA C G G C G A C A G C T C C TA T C A C C G C G C T C GACACCGAGATT A G G G A T A G AG G G G A T T A A C C A T A C G A TGGAAGATCCGT C G T CTGG T A T G C G C A C G C G G A C T G A G T GAAGTAAGTCGGGTAGGGCTTAC T T C T T A T A G C T C C T C A A T C C AA C A G C TGTGGCTACCCC G A C A T C G A T A G A A G C GT A G A C A A G G T AACTCAACTGAC A G T C G C A G A T AA C A C C C C T A A C G A G T CTGTAAGAAGCA C T G G T CC C G G G T T C T G G T C A T T T A T A TGTGGCAAGACCTGT G G G T C C C A C C G C A TGG C G TC T T C A A G A T G A A GA T G AGTGTGGGATCA A A A G A G T A G A A A G C A G C AC C C A G T T C CCCCCCACTTCA A C T G T G G G T C C C CG A A A T T G C G G G C C ATAAACCATAGCAA A G C G G G TG C C A C C T A T A A C C G C A C T A TGGCATTTAGAG G GT T T A C T C G A G C C CG T AT CT A C G A G C A G T C A T A AT GGGAAACACACC C T A G T T C A G C T G C C C C T C G AT G T A G G GGTGTGGCATCTTG A A A T T C G G A C C C A AC T A G T T G T G T A A GTTCCAGGGGTT T G G C C G G A TG G C A T C T T G G T C A T C G T GCAGTAGGTGAA G A A ACCG T G T A C G T T A A T A T C C G C T T C TAGAGCCACCGAGAGGTTCTCTG A G C A A T T C G T A G C C C C A G T A GG A G T G TGAGGGTGGACG T A G T C A A A A G C C G C A GT T T T G C A A G A ACCCAAAGTAGC C C A G A A A T A C TA G C A G C G T C G A C C T A ACCGTCGAGAGC C G T C A CC A G A A T T C G T A T T A C C A A T T GCTACTACAGTAAGC A A C C C A C T T C G A A TGC G T TA G A A A A C T C T T A GC T G GTCCACCGAGTG A A G A C T G G A G C A C A C A C CA C A T C C A G CGAAACGGGAAG T T A A T T C G A G C C TA T C T G T A T G G A G A CTGTTGCCTGTA C G G C A C A CT T G C G T T T A G C A C T T A G C CCAATTTTTCGC G A GA C G G T C A C T G T GC T A AAG C A C G T C A C A G G C G T TATTAGTGCTCTA G A C C T G G T C A C A C G C T T T C C CA G A T A TAATTAACCTGGCG A C C T G T C A C A C C T A AA C A T G C T A A G T GAGCGACCCCGT A G C G C T A A A AT C A C G C T G A G C A A A A G ACGTTGTCCCGG G T G A GT G T A T T T A A G C C C C G T G A C T T AGGACGTAGCCAni T T T C C C C A A T C A T G GAot G A GA G C G C G T C C C C C CtT C GAGCGGGT G A T A C C A C C T G G C A A A A C C C GanAeCC A G A CACGGAGCAG G G C C C A A T A T G G G G G A AiCCCCAACGTGCCTAACCGACCGAGACAATATACCAGTCACTCG T G C G G G A G A T A A GGATCGACCTTGAAAAACC T G A A A G A GGAGCCCCA C C T A Gr C C T C T C C A A G A T C G A A C A T A G GAATTACGAA Ao3 T C A G T T A G C G G T GA C'- CT C C A G G A G A A G G C A TCCCCGGGT A G C G A A T A A G T C T G C G G A A G G C T T'5TTCCGATTTGCTTCGCC C G C G G G G C A T G T C T A G T T C A CCGGATGAA T G T T C C C T T G G A G G T A G TnieCcACGAACGCTACCTAGCTCGATTGTTCGA C A T C C G C A A A T G G G TTCTACCCGGG G A G C A C T G A G CnTeAGAAATGCGTGCCGGCTGGGGTTCTCGGAAGGAAGTACGCGG G A T G A A T GATGTTAAG C G A T TuAqAATCCGCTATCGACGGTGTTCCCACACGTGGCCATTTCTTTGGAGAAGGGGGCC C TGAACGTAeTACCC G A T A G C C C C G C C G C T T G G A A T T G A A CS A ACCTCAATTGTCACGGGGATCACCTAGTGGTTCCGAGCGGAAACCCGAGAACAATezislato)p75Tb(02OQNESDI77PeMV LCm_aGA8NR R50A A G A C G T A C A A A C C T T G C G G G G G T T A G T CTGTCATGGTGAGATTAACGTGCG G A A T C A T T T A T G C TG G G A G T A A C G C ATCGAGACTCCCAG T C C C T G T CT T C C G A C A C T A G G T A T C GCGATCGCTCTCGTCT TC C T G A C T C G C C T T AA TG G T GA A A T T C C G G C G C CG G T GCCCATCCAGTCGA C C A A C G C G T G G T C A T TT T C T G G G A C ATGGTATCGTTCAA A C A G C A C G T CG C A C G T G A C A A G G A C TGATCGTCCGACCTCT G C GT T C G T C A G G C C GC T G TA CT C A G G G C G C C A A C G CC ATTGGCTGGTTTGG G C G A C G G T G T A C A G A C G GA A G C G G A AAGAATCTCAAAAT A G G C G A G A G G A GG A T T A T C C C C A A T GGGAGTCCCGGACAGG C A G C GGAC G C A G A T A C C C C A A G G C T G GTTCTGGTCTATGGACTAGAGAACA G C G G C C G C A G A C G T G C T C A AT C T A A CACCAACGATGACT A G C T A C G C T A A A A GC T C T A G A A T G T GGAACACCTCAGGTCA G T C G T C GC C A G G A G G A T C A A C A C C A CCTGTCATCTCGGT AT T C T A C G T C A C G C GC GG T C CG T A G A G T G C C T C AG T A CAGACGTGACACAA G A A A T C G T A G C T C A T CT C A C T T T C C CGCACGTTACAAACCT T A G C A C C G AC C C C A T G G A G G C T C C C AACCTAAGGGAGAG G C GT A C G T G G G T A A GT G G AC GC T C G G G C T A G C C A A TT TCGGTACAATCTTA C C T G C C G A T A A C C T A T T CC G A G G A C CGGCGACCTTCCCACT A C C C C C C A G A GA G A G T C C C T G A T G G CGTAACCTGGGGTG A A T C GGAA A G C C A C C A C C T C A T G T G G CGTCTGGTCCTACCAGGATGGAACA C C G G C G C T A A A C T C A T A C C GC A G A T A CCCAGACTGTGCCC G C A A C C C C A T G A T AC A G C C A C C G C A A TCGTACGTCTAC T G C A G T G T AA A A T T G C T A G T C T G G C T ATCAAGGGCGGGCC T A TC A G C T T C G A A C CT C C TCC G T T C G C T C G T G T C T AACAGACACGAGGAA A G C T C T A G A G A C T C G C C C C GA A G A T T CACAGACGACAC G A T G G C G C T G T A C C AC G A A T C A T T T A GCACACAACGTG C T G C G C T G C CA A A A T A A G G A A T G A G T GGACGAGAGGAG C G T G AAGT G G A C A T A C C G G G G T A G T A T CGACGGGCGAGTTGGTGGTCCAA G A C G T A C G C T A G C G A A T C A T G TT C A C TAAGTGGCCAAG A A G T A T G T G A G C T T A A CC C G A T A C T A TCAACCCGCGAC A A C G T A C G T G G GA G G G C G C C A G C A T G CAGGATGTTTGAGC G T A C G GG G A G G A C A A G C G C T C G A G C T TCTTGAAGGGTT GG A C A T C G A A A C G A CA AnG AT G A A T G A C G A G G C Goit ACTCGCAGCTGAATCT C G C G G G T A T A G C G G T C G A G T GCTCAATCCCG A A A C G G T A T T C C G A T T AatnCeTTCAGAACTCATTGGTCGGAGATCCTACACA T T A C T T C G G C C A TCCGGTCATTTCG A C G T C G A GiTGTATCCGACGGGGTACGTACAGAAATTAGCGAAGACGTGTGACGGGTAA G G G GCAGGGAGGGGr A G G A C A T A G C G C G AGo3 CG T A T C G G T C G T A G T C'- TA5 GCGCACTAG C A C G G G A G A T C A T C T T C G G C C A C TGAGATT A A T A C T C C G A T T G G T G G T C T T A' G C T A A CCGGTCCCTC C C G C G A A A G T T C G G C T T TiT C C G C G G T C TTCTCCTA T G A T C A T C C G T G C C AneCcCT C A G A A C G A G G GCGCAAGA A T A G G A A T T A C GnAACTACAGGACCGACGGACATACACTAAGTACAAAATAAC A T T G C C C G AAGTCGTTAGC C C G G TeCuCCAGGACACCGTGGGACCAACCACGGATCTAATTATACGGGACGATGTGTCAAG G CACTTACAqCeGGGTA C T A G T A G C T G T T T C A C G T A A G G G G G GCTATAGAC T C C T T G T G A C A A G G C T C A A A G G AS G C G G ATAGATGGTCGGTTGCCCCTAGAAGTTTCTGGCTCTGGCTCCCGAACCCezislato)p 13824Tb(331102OQNESDI879708P V P PeM MV Vma LC_CNGRA9 L _MCR50GRA0 L _R60GRA1R60C G T C C C G C C A A G C C T T A A C A T A A G A C G G T GTCTTTTTACAAGACTGTCAAGAT A C C G A G T C G C G G A T TT C T G C T A A G T T CCTCGTACCATT T T T C A A T A G A CA T C T A C G G A T T A T G G T ATCTCTGCTTGA C T G T C GA C A T C C A G A C C C G T G G A T G G T ACCGTTCGGGGC TT T C A A C G T T T A C T C AC CC C CT T T G A C G T G G T A A AC C TTTCTGAAACCA T A A G A A G A T T C G G G T G T G T CC G T T G C A GGTTAGACGAGC C A A T G T T A T G T C T C AT T G A G C C T T C A A AGGCACATACAG T T C C C G A C A CG C T A A A A A A G T C C A G C T AGTGATATCTCT T A T T TT T A C C G G A G A C A G C A T T T C G C C TATGTGGCGCAGG C T C G G A G T C T C A C T CTT C G AA A C T A A T G T A T C CC G T CAGAAACTCAAT T G G C C T T T A C T A C A A A G T CT A C T C T A C AACCTAAGTTTA C T G C A T G C G G G T C TC A G C G G C C C A A G G CCCTAAGATGGC C G G G G G C T CG C T C G T A G T T T T G C A C A C GCAGTTGGGGGACT G C GA C T T G G G G C A C C TT T A ATG T T G T T C T G A G C G C A GTATAACTTGAAA T T C G A C T C G A T C C A T G T A G C C GA C G C A CAAGAACGATCC G G G A C T C G T A C C A T T A AT A T G G A T T T C ACAAGGACGTCA A G G C A T C A C T C AT T T T G A A G G G T G A C G TAATTTTGTTAA T G C G T C CC C T G A G A G A G C T A A T T A C C G CAACCGCGGGGC C AT G T A G T A C G A G A C AG C CC AC C T T T T C A A C G G G A AA GCACCACTAGACAT A T C A T A T A A C G G A G T T T G G AC A A G T C T GATAGTTGACCG C G T T T A A G T A T C C T CC A C T C A G A G G T G CAAGGTTTAATG A G G C G T A C C GT C A A G T C G A A A G T T A C A CACCTACTACAT G G T C TA C A G A C T G G G A A C C C T T C T G G A GGGCGGGAGCTAA C T G G T A C G A T A C G C CTC G A CA A T A G G A G A A A C TT T A AGTCTGAGCAAG C C G T C G T T C T G A C T C G A T CG C C C T G G A TAGACAGGTCTT C T A C G A G C C T G C C CG G A C C T A G G G T G C GTCACGGCTGTGTC G C G G G T C CA T A T T C A A G G T T C A C T A A G TTGTGGTCCTCA T C CC C C T C T C A G A T G GG G G CGC G C T A T C A G C C T T G C ACTGAATTCCCAA C A G C A G C T G C T T A A A C G C G A C CC T C G G AGACACGCCATA A C G G T A C C A G C G G G C C AC T A T G T G C G G AAGCGTTGGGAT A G A A G A G T G C G AG T A G T C G C G A A T G T C GTTTAACCTTAT A G G T A G AA T A A A T C A G T T A A C A A T A A A CGGGGAGTTGAC A CC C A C T C G T G G T T C CT C CA C AA C T T A T G A A G G A G G CA T GAGCTTCTGCAA G T A G C C A G T G A G G C T A A G G CA A G T C T T CACACCAAGTCT G G G A G C G A G C C A G A AT C A A T C G C G A G A ACAAATATCGTT A T C G A C C T C CnT T G C T C C A G G A C G G T C C ACAGTCGCAA G T C G C Aoit TatTCGGTCGACGTTCTGATCCAAGGTAAGCGGGGGATTACTGGGCAGATGTTACCCG C GCTGTTGAnCeTAiATTCGGA G T C G C C C A G G T G T C T T C T G C A A T G GGACAAGGGTGATTCGTAT A T C G G C T A A T T T A G G C A C T GCTACCAGA C A T C T A A A C C G T C T T C Cr A T G G G A T C T T ATGCTAAGGT G A T A G C A C G A T C Ao3 G C T T A A T C G G A C C G AATTCCATTG A C G G T A C C C'- GGTTTGGAAGCCTTGGTTTGAGGGCGAGACTCTTTCCGTAGAGGTAGAAG A A A C CGTCCACAC T A'5A G T A T C G G A C A A A A C C A A T C G C A C C ACATTGCniCeGTcCCTTTACAG T G T T A C C A C A C A T T A A C G C A G A A CCGTACGTCGTTC T C T C G G T A T A A C G G C G G C AnTeGGuATTACTTCCTGTACATTGAATGTATGTT A A C A A A C A T G A G G G GGTCTCAGCTT T C C T G G C A G A GqCCTCTGTTGAACCAGCGACCAGATATCGTAACGGATAAAACACAG A C A C A C ACGACGCCCTG C T CeT A T C A G G A T G C G G A C C A A T C A G G C CGGCCAGCCSTTATCGCTATTAGACACGCAGTGAAGATATTCCTCATTGCAATGACGGACAGCAGTCGezislato)pTb3(76OQNESDI18PeMV LCm_aGA2NR R60T C A T C A A G T C A G A C A G G A G T A G T C G A A G T ACAACACAACACCTGACTAA A G A T G G C C A G G C C A C G TT G T A A T C T A CCGAGAGGCCAC T C G G T T T A C C A AC G T C C A T A C C T A T A ACACGGGGGACTCC G G C G G CT G A A A C G C G T T A T G A C G T A G CCCACTCGTACT GA T G C T A A A G C A C C AG TC C TG G T C C A T A A C C C A CC G CAAACCAGTAGA G A G T G T T G G A G G T C C T T C TG A G A A C C GGAACGGTCTAGTC G G G C A T G C T C T T CA A T C C G G A C A G C C CGTGAAGAAGGA C A C C C G C GG G G G A T A C C A T G G G A A G G GAGTACCCCCCC T C TA G A G C A C C G C C AG A C CCG T A C C G G T A A G G T A T TGGGCCTGAATCGTC G A G A A T A G C A C G A C G A G G A AG G G A C C CAAGTGAGGGGC C A A C C A T G C T C T G C CG A C C A A T A C C G GGGCTGAGGCAC A C T C G G C A T TA G G A T G C C G T A A G C A A TGGCGAATCCCT T T T C GCTT A C A G C C G A T T A A A C C G T A C ACCCGCCACCTTGGTCCCACTAT A A T C A C A C G T C T C T G C C T G G T AA G C A CGTCTAGACTCA A G G A T C A A G G T C A G C C TA T G C A C C T C GGAGGACGGCCT G C C G A A G C A C C AA C T G C A G G G G A G C A CTGTGTCGTCGAGC T G C G G CA C C C A A A A G G G A A C A G G A G G ACACGCGCATGT TT C C A C C A C T A A C A GC CA A AT T T C A T C G T G C G T GC C CCTAGACAGCGA C A C A T A T G T A A C C C G T A G TG C C C A G A ACACGCGCTGGAGC C G G C A A A C A A G A TG A G A C T G C A T C C T GGGGGACACCGC A T C C C T T TG G T C A A G A C C A G C T A G T T GACGTTCTCCCC C A CT G G A C C A C G C T AC G G CCC T T T T C T G C A C C T T A CGTCAGCAAGATATC A C C T C C G C C C T A A C G T C A T CG G G C A A GCATGCGGAGAA A G T A T A C G C G C G G G AG G A A C C A C G T C CCCAGGATCCCG C T G A T T T A T GC A T C A G G G G C C A G T C A GGGTCCTTGGTC A C C C ATCT C G C G T T A G C G G G C C A T C C A CACCATTGATGGTGACCGGATCA C C C A T G G T C G C G C C G T T A T A A CA C T T ACAGTTGCCACC G T A G A T T G A G A C A C G G GC G C A C C A T C CCCTGGTCAACC G G T C T A C A A T G GC G C C A C G A G A C A C C CTCTGTCAGGTCGG T G C C G GT G G A C T G G G A T A A A A G A T A G GGTCCAGGGCTT AT A A G A A A T T G G C T GA CG C CC A G C A T A C C T T C G GT A AACTCGAGGCTA G C C G A A G A C G C G C A C A C A AC C C T C C G TAATGCCAAAGATG G G C T A T C G A C G C CC C C C A A T A T A A A G CGAGGGGCTACG C G G C C A A CC G G A C C A C G A A C G A C A C C AACTAACTCGGT C G CC A G C G A G C G C C CC A T Tn T G T A C G C A G A C T T C G Toi Tt CCCAGGTGGG G T A A C G C G C G C T A G A A T G C A A GtC A G A TACACACG A C A C A G T G C C C T A C G C C C GanTeCT G T A A C CAGCGCCACG G T C T T A C T A T G C C C AiCCC TTACTAGCAAATCTGCACCCTAATTCGGGCGGAATCACGGCTTGCTC A C G A C C A T C G GTAAAGGGGAGCAACACGT T C G G A GTTTCCC T T C Cr C C T T C A A C C A A G C G T A G G T C A C T TGGCCAGC Co3 G T C C G G C C C C G A AC C'G A A A G T T C C G C C A A G T- GTTCCCA A A T A T A T A T G T C C T A A C C T T G G C T C'5TTGTCCACCGCCCAT C C C C C C T G G G C G G C C A A A G T C TCACTTCGC G C T T T T T A T A C T G C C A C C AnieTcTTTCCTACCGTACTATGGAAGGAGCT T G G A A C A G T G G A C C C CTCCGTCAGAC G C C T C A T C T C G CnTeTAuCCCTTTCCATCCCAGAACTGCCCTATGGCCGCGTGACAC C C G G A C T G AGGCTATCT T C A T G CqAATCCTGGAACGACGTTGAAACGCGGGGCAGGAGGGTCCTTACGGGTACATG C G CCTCTGATATeACT C T G A A C T C T T T G G A C A G G T C T C T T C C AS CCGCCGAACTGCAACCCTGCTCCAGAAAGGTTCCAGAAGCTATGTCGTCCTAGCAACezislato)p08Tb(02OQNESDI28PeMV LCm_aGA3NR R60G C A G T C T G T A A C G G G G A T T G C A T T A A AACCTTCAGTCCAGTAGGAAAATAAACA A C A G G A G T T AA C G A T T A G T T G A T TTCTGTTTTTGATCGG C A TA A C G T G C A T T C TT G C TT C AT G G T A C T T C T A T C TA T ATATCTCTTCAGTC A T T C A G A G A A C C A A G TC A G C G C G T TTTCGTACAAGAAA C T A T A T A G T AG G G A G C T G T C A C T A AATAATTTGTTGTT T T A TG C T C T T A A T G TC T T A GG AG T G T A A A T A C C T A T TT GTTGTCTGTCACAC T G C C A A A T A A A G T C C T TC T G T T C C CTTTTGTCTTTCTC G C T T T T C A T G TG T T G A T G C T A A T G TGGTAGTTGATGTC G A T T AG G C T C T T T C CA T G T A AGA A A G G G C T A T A C T T T ACAACGTTACTAGCC A A T C G A T G C A A C T C T A T AT G C A C C GGTCCTTTAACAAA C G T T A A G T T T A GC T C C A G A C T C G T ATTGGTATAAGTTA G A T T T AGAC T C T A C A C G T G T C G T G G CGAAGACTGCATTATTCGCATATAACC C C T G T T T C G G T A G A T T G A CC A C T T ACTCCACTATTTTG C T T G A A A T T T A G TT A T C T T G T C T C GTTAACGAGTTGTT T G T T T T GC C C T A C G G G C A T T A A A T AATCAACTATGTTAGTC A T A T T G G T T C T T T TTC T G C TC A G G C C A A A T GC C T A CTCTAAGCCACGAG T A A G T A T A C A T A A AA A T A A G G A T C ATCCGTAAAATGTG T C C A G C T AC A A C A T T G C G A T T C G G CTGGGTATCAATTCTG TC T C T C A C T A A A T T AT GC C A TA A G T A T T T T C T TC G T TAGACAAGGCTGAC C C A A A T A C A A A T A G GA A T C T A C G C CATAGTGAGTTACG T T T A T T T T GC G C T A A G T C G G G A A C ATCCAACACACTTAAA C TC A C T A A C G G G G G TC T TC C TG A T A A A A A T T A T TC T C GCGGACAGATCGTG A G G T T T A A A A C T T A A TC C T T T C T G G CACACAGTATAT C A G T T C T A T T CC T C G T T T A G C T A T A AAGGATCGGACACC G T T T AG T A T C T A A T G G A T A A T G A T C ACCGACACGATAC C C G A T T T A T A A G C TAA G CA T A A T C A C G T T A TC T CCGGTCACGC T T A A G G G A C C G A T A G A G T T GC T C T G C TACTCCCAAGAA A T T T T G A A A A T T T G GC T G C C A G G T C T TGATAAATGT G G A T T A T A T T GT A G C C C C T C T A C C A A TCGACATAAG T G T T T C TT C G A T T C G A C C T A G G G T G A ATATTGTCTG T A CC A A C T A C A C T G TA T T GTT A A A T T T C T C T C A C T TTTTAACACTC G T A G G T G A T C T A C A G G C A A T T AnT C C T TAATGCTC A G T A T T A A A T A T T C A A G C Goit CTGTTCTCTAGGTATTTTATATGCA G C A A C A G A T A A C C T T TGCAAACGT T A G A A T T T G A T T CatnTeTTATACGTCTACATGACTCGGTATTACCATGTTGTG A C A T A G T T T TCTAGTACTCT A T C T T TiTATCTTGTTCTCCAAAACTTCTATCCTGTTAGGTTCACCGATTGCATCTAC T T CTAAATCTTr G T A C A G C C A C C C T TGo3 GG A T A A T T T T T A A T A'- GA5 GCCCCCGCT A G G T A G A A C T T A C C T T T T T C T C TGACCAT T T C A G A A T T T A C C T A A T C T C A' G G T T T CGTGTGGAGT A A G T T C C C T A A C T T T T CiG A T C C T G A T TAGACCGT T T T G T C C A C A T C C AneTcTG T T G C T C G A T T AGATACAA G G G C A A A T A G TnTACCATCGTTTGTATCAATTCGACTCACGACGCTGATACT A T G T C C A CACGATAGACT G T C TeCuCGGCATCAACTGTGTACCGGTAGTTCTGTGTAGTTTCATGAAAGGATAGTCAAA CCCCGTqCeCGAAACAG A C G G C A G A C C A A A T G C T G C G T A G TATTCAGAA G C T T T T A T C C C A T G A G T T C A TS C T A C C TTTTCTTGTCCTTTTACTCTTGGTAGATATCTTAATTTCTATGAGezislato)p 3 758Tb(569372OQNESDI384858P PeMV MV P MVma LC_NGRA4 LC_CR60GRA5 L _R60GRA6R60A T A G T A T G C T A C A G A T A A G C T C T G G C A A ATTCAACCTAATATAGTA A C A G T T T T T T G A T G T C TT T T A A C C T CCAAAAACTTTA T C G A T T T T A T T TA C A C C T T T T C C T T TCGCGAAAACCC A T G G T G CT C C T C G T C T A T A T T A A T T CTTACAAACA A T GA T A G C A T C T A G AA A T TGT G A C T C T T G T T T A C TACACCGTCTACC G C A A A C A T T T G T T A T C G A C AC G A C T CTGTCATCTAAT A G C C A T T C C A C T A C TC A C A C C T T A T CACACGAGTT A C A T T G A G G C CA T A A G T C T C A G A A G TAAAAAACTTTG A A G A A TA T C T A A C C G A T C C T T A C A T TAAAACGTGAGG AA C A A C A T C T A C C A AA CC C CA G C C C T A A T A T C CA T CATGAAATTT A A A A A A A A G T C G A A T C A C GG T C C C T CCTGAAAAACTA G T A T C C A C A G A T C AT C C T G A A C C T A GACAATACGTCT G A C T A T C A GA A C C A T T T C T T G C T G T GACTAGGGGGCT A T C AT C C T G T A G C A T T C C A C T A A A G GTAATCAGACC T G C T C T G A C C A G T AGA A T TC C A A A A A G A C C GT T C GGGAAGATTGAA T T A C A T T A G A C A A G T C GG A C T T T A C CATTTACGTAAA T A A G A T A G A A A AG T C C C C C C G G T G C CAAAATGTTT A A T A A T A CA T C A A G C G T A G T T A C A A TCCAGAGAAAAT C G TC A C A A A T T C C T TC C G GTG C T G A T A G T A G T T T ATCTTCTTAGACT T G A A T G C T A T A G A T A G A G A AT T G G T GCTCATTCAA T G C T A T G A G T T A C A A AA C G T C A C A G GGGAAGTGAATG T T T G T A C C A A AA T G T C A C A G G G A G C GACCGAACTATT A G C A C TG G A G A G C A A A A T G T A A A A T CTTTGGACAACT AT T G G C A G T G C A A AA CT AT T T C G A C G C G C T A GG AAGTGAACCGTG T T T A A C A A A A A C G A T G T G GT G G A A C GTCTAGTATAGA A A G A C A T A T A T C A GT A A A G C G G A T G ACTAGGTTCCTT T T T A A A G G TA T C C G A A T G T T C A T G C ATGGTTTTTG T T T G CA A G T A A C C A T C A T T T T A T A T CAGCTGGACGAGC G G G T A C C A T A T T G TGC G G GT A T G A T T C A A T GT G A TAGACCGGCCGT G A A T G T C C G G T A A A C T CC G C A A A C A GGTAAAGGTA T T A G A T T G A A G C TT G G G T C T C A T A G GAAAAGTAGGTT A T T G G A G CA A A T A A G T G G G T T G T C A GGAACAACGTAA A G GA T G A A A A T G G T GA A T ACC A C A C A A G T G A T A G GTTTGAGATCT A T T T T T G A A T A T G G T T C G A T AC T C C CGACTCAGTAAG T T C T T G G T G T A T T G C TC T G T T A T A C GATAAAATGGTC A A T G T A T G A T CnG T G A C G C A T A A G T A TTCAACCTCA A T A T A T Coit AAGTGCCCGGAGCTTATCAATCAATTGTATTTTCCCTCGTACAATGG G C C AAGATGGAT TatnAeCA T A A G G A T C T A T G G T G A T T C A C C TGGGTiTACGGGAGTTCGGG T C T C C T A A T C A A A C T A G G G A CAGTTCT T C A A A C T C T A C G C A T T G G Ar A A C G C G ATTCTCTAAA G G T A G A A C T A T G A A Go3 T C G A A T C T T A TCTTTGGTTG A A A A T T T T T G T'- T G A C A G A C A T A A T T GTACCCGAGT G T G G C A C5 T A T T G T G G A T G A T A G A T A GTATTT T T A G T' A A G G G G G A G T T G T C G A T A A T ATTGTGTGGA CniTeTC G T G G G A C A T A A T T G G A T C G G G G GGGGATCcGTTA A A G C A T C C C C A T A A G C G G T T T G G A TnTeAATuGCGAAGT T A C G A G C T A C T A T T A A A G G A G G TGCATGAAC G C T G A G G C T T A A G A T T A A A CqATCCAACCGAGCTTTCGTAGAT A C T T G A C G A G T G G T A T GTGAATCAA C T A T T C A A T T G A C TeGATATTTAGTGAGTTCCCCGTAAGGATTAAAT T C T T A T G G G G G TTACGCA C C A A C G G G G TS A C G C C C A C T T T G T A C G CAATTGATTCCAAGGTTGTGAACezislato)pTb(OQNESDIemaNC T T A A G A T G C G T G A C G T C A T T G C C A T T T T TACATGACCTCGTACGTCATTTAT A A C A A T G G A T G T A T TC T T G G A T A T C G CCGAAAGCTAAATG A T G C A T A A GA T T A T A C A T T G T G C T T A CGACCCTAGGGACA G C GA T T A C A G T A T T C GA G A TT GA T A T T T C G T A G G G T TC TTCACCAGGTCATA G C A C T C G A T T T T T G A G G G AA A T G A G T GAATGATTTTCAAG A A A C A G A G C G T T TC G C A A G T A G T T T G ATTGTAAACCCCTA T G A T A A AT G C C G G T A T C T A A A A G T C C TTCAATGCCCGAAA AT T T A G T T C T T A A G A AC AC A T CA A T G T G T T A A A T GT T C AGTGCTTTGTTAAT T T T G G A G G T T C C G T G C AA A G C G G T G A GTTTAACCAAGACA A A T C A T A T G T GA T T C T T T A G G G A G T G AATACTTGTAACAT C G A T ATCA A A T T T A A T A T G C A A A T A C T TAGTCTATATCATTCTAACAACCGT T C A C C T T C C A A T T A A G A T C T GT G T T G TTTACTTCATTACG C G G A A C T C A T G T G T GT G A T G T T A T A T AACTAGAGGATCCC T C T C A T A T AT A C T G C T C A T A C G C G T A TGGAAACGGTGTCT T G AG C A C G G T T C G T A TC C A TA TT T C A C T A A A G A T C C CC TAATATGTGTTGCG G T C G C C C A T A T T T T A T A C GG C T T T T T TAGCAACATAGCAG G A A G T C C C G T A C TT T G A A G T C G C T T G AGAACTAAAGGTCC A C T T A T AA T G A C T G A C C T T T T A G C A T A AAAAGCCTAAAG T AT T A C C G G G T T T A C CG G CT GG G T A A T T T G A T T G A AT TGAAATCTGGAT T T C A G T T G T A T T G G A C A T T T CC C T C G T GGTTACATGCGG T G T A T T T A T T G T T T G CG T C T G T G C G C T GACCGGTTCGGA C A T G G A T A T G AG T G T T T G A G T A T C T A A TACTCCCCCTCT A C C T T AT C T T T C T G T C G T C T C T C A T T T GAAAGGACCGGC TT C G T C C C T T A A T G T AC TT T TC A T T T T T G T T C T C CG A CACTGTAGATTT C G T C A A G C A T C T C T A T C A T TT T T T G T G TTGCGGGGATGC C A C A T G T A A A G C A C TA G T G A C G G G T A A TATCGCCGTCAA A T T A A G C A G AC T T T C A G C A C A C C T G C G TGTATAATTACA G C G G CT G C T G T A G A T A T T C T T T A A G A A GAGAACCAGGAGT G G T T T A T A A T T C G C ATC C G TT A A T T T A A A C A A TT G T AACTTGTCCAAT T G G T C A A C T G T T C C T C A T GA A T C G A C G TATCTTTCTTAG T G A C A C C T T T C T T GA C C C T C G T C G A C C TACGTAATAGTT C T T C C A G A TA T G G A C A G G T A T T C C C C A CTTATGTGTCTG A A C TACT A G C G C T T C A T G T A C C C G G G T T AAACAAATGTGTCACAACTGT G G G G A C A A G A G A T A G T T T C C C T Ani A A A G AATGTTTGTT A T G C A C A T A C T A G G C A G G Aot G G C T G A A A CTAAGTTACC G G G A C T C G T T T C A T AtT A C C T C T T G C A G AGATTGGT A C A C G A C A A T C GanAeCC T T T A A G T A G T G G T CGACACTTGA G A C A C T C TiAATCCGTATTGGACCGTTATGGATCTTCTCCCGTATGATCGGAGGCGTAGTAGCGATCGAACATA G T C AAATCAGATGGAr AG T T A T T A C A T C C T T Co AACTGGGACC A C G A A T T G G G T C T A T A A A G A A G A'3- CTTTACGAACAGAGAAAATAGA G T T G A G G A A A T A C A G C T A AGCTTCCTT A G T A T T G T C T A A A C T A'5TTTGCTGTACTCGGTGTACGAAATCTCCTTGGGGCA A A T C C C T G C T T CGGAAACTATT C G A A A T A CnieCcAACGTCCCACGTGAGCGTATCTGTTAAAGGGCGTATCGCGGAGTTTACTGA C C C GGGGACGGTTAnCeGTuCAC C A T T T C G G A T A T T G A G G G A A T T A G AAAqCACTATCGACA C A G A T T A C C A A G T T T A G A C A G GeTGATCGATTGAAAGTTAGGCTTAGACGGTAA T T T C G G A G T T C T A A A G T ATTATGAAGTTTACCA A G C G C C A G A G C A G CGCTTTGCT A C A G T T G A A C GS G T A C G T G G T A C A T G A A CCCAAAAGTAAATTATTTTAAAATTezislato)p9Tb5 9(9941OQNESDI6878P V PeM MVma LCG_CA7 LG_A8NR R60 R R60C A A T A A C A A C A T A C T G T A G T A A G T TCAATTTATTGCCCTCCGGGGAAATG T A T C T T A C GT G T T A G G A T G A A CTCCTGAGGAAACA A A TG A T C C T G C C C CT C T CG T GC C G G C A A T T T A GT C ACAGGTTTGAATTT C G C G A T G A T A T T GA A T A G C A G ACGAAAACAACGACAT A G A C A GTAG T T T C C A T A A A C T C TATTAGCGTACCACTAAGCGAACGTTGGT A T C A A T T A C A A C A C CA G A G G C TTACAAGTCTTCCT C G C T T G C A GT T A G G C G A G T A T TTGCCCATTTTGATTA T AA T C G C T A C A C CT A CA A AT C G T C C C C T A C AG A TAATCCCACCGGTGGA A A T T C C A G A A A TA T A G G T A G G GCTAACAAAGTATT G A T T G AAAA A G A T T T C T T G A G C ATACCAATCAAATTATGAGAGGGGATGGT C T T A T A C A T G T A T T AT G A T A T TCACGACAATAAATCG A G G A C T C CA A A A G T G G A A T A T TGACATAGACGCTA A CT C C C A A T A C C A AT T CA A G AC T C C T C G T G G TC T G TAACGACCCCGAGT G C A A C A T A C G A TA C A A G A C T A G TCGTTTTCTAATTA A A T G A CC T A A G C C A A G C G C C G A TATTATACTAGC AA C C A T C G G C G T T CC AC T C AT G A G A A T A T A AA T A TCTCTACTACCG T A C T A G G A A C A A T A TA T G A A T T T GTGCGGTGATAT A T A C C C A A A CA T T T C C T A G T T G A TACATCGGGC A T A T C TT C A G G C T C A T T G G T G A A TGGATTATGATT TG A C G T G A G G C T AT CT TA A A G C A A C T G A T GG GTTGAGATCT C G A T A C A G A A C T A C G T G C TT A T A A TTTCAGTA T C T T T T T A G C T T C C T TC T G G T T T T CCGTGATGTA A T G T A C T T A C T TT A C G G C T T T G T T ACGATAATCT C C T A C G A AT A T A A G G T A G T C C T A G CTATAATATC T T C CC C A T A T T C C T T G G T C A C A T A TGGCCGAT AG A A A A T T C A A G T TC TA TT C G A A A A C T T T T TA TTCTATAT G T C A A T A A C A C T C G G C T A T CC C T T TACTCCAGTA T A A A G C C C T A A C T A T GA A T A C A G C GGAGGTCT T A T A T T T A G G A C TA T A A G T T G A C T TTAACTTTAA T T T T T T A C TG C T T T T C A A T A A A T T ACAGGTGTTT C C T C AA G T T C C T G G T A C G C T A C G A TACAGTCTCT TG T T C G G A G G G A CC CAA G C A T A T G G A T A T TnCTTGACAT T C G T G A G C G A G G C T T T C G A C Aoit TTTTGGTTATTCAA A C T G A C A A A A C C T C C T T T CTGATTC T G G T A T G T A T T G G G A T CatnAeTTAGGAGAGCTTGACCGATTG A A A T A T C C G T A T A A GGTTCGAGG C G A G T A A G C A C AiTTTAGGACTTACACCTACGAATGGGAATACCTTGA A T A T G A A T GAATTAA A C T T T C Ar T A T A T C G T C C C A A T A C C GCACCG C T T T Co A A T T T G T T C A A C A G A C G G T TATTACTA C G'3- A5 CTAATATCATAGCATAAACACATGA T T C A A T G T A AAGTCGG'C C C T A C G T A A A A T AiCCAT A T A T C A G A A A A T C A C G A A A T A C CneTcTACGTAAAC A T C A C A C T T T A T A T C G T T A TnTAAAGAATGTGCGCCTTT T A A A A T T T G G G A T A G C GGAAACATA C A A T C T G A T A A T A AeAuCTqGGTATTTTACCAACCCTCTTCAACCA A A G G G T A A A A C ACGATATAA A G T T C A G A AeAATAACCAACATTTCGAACACATTACCGTATGCGAGGCTCTAAGGTTTATTAAGGGT A G G T C ATGTACTGTATTG T A TGACG A AS T T G A A A T G T T A T C G A C T G A T A G CGAACCGezislato)pTb3(14499OQNESDI8898P V PeMC MVmL _ 9 LC_aGA6 GA0NR R 0 R R70C A C T T A G G C G T T A A A A T A G T G A T T C A G A T ACGTACGGATTTTACATAATTT C G T G T A A G T C G T C C A TC A A A A T T A C A TTCTCTAGTTCC T C T G A A G G A G TG C A A A G G G A G T T G A G TCTACCGCTTCAAG T A G G TA A C A A T T T A A A A G G C G G A G C T ATGGAGAATTAAA G G A A G C C C C T G T A A ACA T A T CG C T C A G T T C G C AA G G T TGGGTGTTCAGAAT G G A A A T G A A A G T G T C AA G A T A G T T A A ATAGTAAAATCCAT T G A A A T G C T CG T C G A C C T T T A A A A A C ACTTCGTCGAAC A G G T ATCC A T A C T T T T T G A A T G A C A C A GAGACACAGGGGTACTAGATCAT G C C A T A C T T A A A G T A A T G T T A GA T A A GCATTATCACTCTC C T A A A T T A A G A T G G C TA T C C T A G A C G AGGCAAATACTT T T A G A A C A A G TG T C T T T T G C A C A T A T ATTAATGGAACAAT G A G T AACC C A T T C T C A C T T A A A A A A T T ATAACAAAACACTAATGGTTCGTGA T T G T T A G A T A C C A A A G A T T G TG T T G T TATGATGATACT C C G A A A C A T G A A A T T AT G G T T T C C A A ACCATTAATTGGTG G A T T G A C T G TT C G A A T A G T A T A A T A G CAGCAGATTAAT A G T C CCGC G G A C T G A G A T C T A T A G G A G CTGAAGGTAATTTATTACTAAAG G T A T G C C C C C T A A G T A G A T G C TA T C C TATAACTAAACTAG C C C T A A A G G C T G C A G CG G C A T T C T A C AGTTTATATCCTAG G G G T A G G A T CA A A T T C A T C T A A T T T T TGAGGGGACGTATT G T A GCTA C C G A C G T A A C G A G T T G T T T G TAAGCTCACGTTAAATAAATGTT G A C G A G A A T G T A A T A G A T T T GA C C C G ATGGGTAGTATATT C A A T G A A A G T C C G A AG C T C A G A A C C A TTAAAATTTCAAGA T G T A A G T A TG G T C C G C C G A T A G A T T T ACCGTGGCCTGG A C A CG A A C G T C T T C C AT G T G CGT G A G A T C T G T G G T A G TTAGTTTGGTAGGTA C C A A T T T G C G T C G T T A A C T CA A T T A A CTTCTATATAGATC T G G A G A A A A C C A C TC T C A A C A C C A A A TATCGTATCAGG G T C A A G A C TT C T T A G T A G T A C T A T G A ATCTGTTACGAGGA C T AA A T A T T G G T T C TT T G TAA T G C A G A T A A A T A G T GGAAGTCCAGTCACG T T C A T A A A A G C A T C A A A A A AA A C A G C GGTTATAAAAGC A T A A A C A A T G A A G T GA A G T A A G A T T T GAAAGAAATTCTTT C C C A G T C C TT G G A C T T A G T A G G T A T A CCCGAACTAAAAAA A T CT T G A C A T A A A A T AT A C CT AG T A A C A T T T A A T G C TC CAGACGGCAGAG T G A G A A A G A G C C T T T C C A A AC A A G T T ATTTTATAGTTTAA A T A G T T C C T C A T T Tni C T A T C C C C C G C C CTGTTTTG G T C G T A A A T C A Aot G A A C T A T G G G C G T T C AAAACCTTCA C A A C C A G CtA T A T C C G T T G T A A C A C T C T TGGCAG A G T T A TanG T G G C C A T T A T A A A T G T G G A C GATTGGATCT C CeT T G A A C A C A A A T G A T T T G A A A G A G T GCTGAAGiGTTAACC A G T A C T C T T A G T C G G G C A G T G T C C Tr T T TTTCTAAG T C A C C T A A T C G G A T T T A G T A T Co T T G A T TGTCTCCGTA A C C T G A A T A G C T T T T A C T'3- CACCAACTTTCGAACAAAACAGTTGTACT G C G A T G G T C A A A T A TTCTGTTGA C T G T C C C T C T T A'5TCTCATTACCGTGAGAGGGTTATCATATACTCCGGTGAATG A C A T T A A C CTCTAACTGGT A T G A AnieTcAT G C G C T C T A T G G A A C C A A A G C TAGCATCAAA TnTG G G G C T C A T T A C A A G T G A T T A C A G G TCGTCeCAuTCTqCCGAATT T G T C A G C A A A T A T G A C C C T A T C A TCTTTCGGATG A T A A A C G T T G G T T C T T T G G TeCTTTTTTGAACCCTCTCTTTTTAGATAGTAATACATC A A A A G A T C T A C C A A T TATATTGTATTATCTA G C T T T C T A T T A TTATGGG C G T A A C C A A CS A T A C T C T G A A T T T A G A G AGAGTTGCAACAAGTTATAATTTezislato)p84Tb(89193OQNESDI0919PeMV P Vma LCG_MA1 LCG_A2NR R70 R R70T C T A A C G G C C T A A T C A C C T T A C C TTGCAAGAACTGGGGTCACCCCATCTCTGGGG G G G T G A GA A G T G A A C T T T A G T G AGGAAACACCATATTGT A T A A G G T T A T T T TGG A A G G AT G T T T A T C C CT A C A G AACGGCGCAGTCCTCC A T C G T T T G C TT T T A G G A A T A T C CGTCGCCGGATTCCGG T C CT A A G A A G G T C CA T T GC C TA G T A G G T G G T C G AT G TTTATGAAATCTATAGGC T T T C C A G C T C T GA G C C G A G C C C TGGTTACGCTATCAGT C T T T GC G T C A G A A AT T T C A CTG A A C A G G G A C A A T T TTTCCAAGTTATACCTT G A C T T A G A T C A G T C CC G C T C T A ATCTACTCACCTCGACGA A A A A C G CG G G G A A G G G C T T G G A GACGTCTGCTACATCTT G T A C C A A T A A C T TAA C C C T TC A A A A C A G G AT T G T C TGACGTACTGTAACTT G C T A T G A T T GA C T C G T C G T T G T TATGTGGAACGTTGAAAA A TC G C A C C G C C T C CA T CT A C TT C C A A T C A T T A AT A C CACTTGACGTAGGGAT C T G G A C C A T T A TT C C A C G A G C T ATTTTACTAGCATGAA T C G A AACT A C A A C A C A G C T C A G C ACTAGGAAACTTTTCTCAGTCTCAGC G G A G G G G G C A C G A A A G A CC A A G A TAATCAGGTAGAAA A A A T T T T C A T A TT A A T C C G G A C A CTCGACAGACTTTC T C A A C TG G T A A C T G C C A C G C G G C T ACCCGCTCGACCCCT A A A A T T A G G G C A GGG C G CT T T C C A T A T C T TG A G CGGAGCGGGGGT A T C G C T G T G T G T A A T TA C G G G T A G AAGGGTCGGGAC T C T T T A T A G T TA G A A C T C T C T A A C CAGCACCCGTACCC C A G G AA T G C A T A T T A C C C T G C C T T CCAACTCATAGCG A A C T C G T G A G A A GAG C A TG G A T A T T G G T T TT A T A CTATGAACAA T T C G A T A A T C C A G T A A TT T C G A A T G TAACTATACTAA A T A A C G C T C C G CC C T T C C G T A A A C A AAACTCCGCC G T A C C A T GC T T A T T G A A T G C C A T C T GATGTCCGAT T C T TA T C A C T G G C A T G A T A C A G T C A CGTAACTTGTT G G T G T G A C C A T C CAC A TC C A T C A G A G A A G TC G TGTTCACGTG C G G T G T G T T G G T A T A T T A CT A T A C T GAGTAGGATA A C G A G C T T C C T A C G TC C A T C C A C A T ATCACCTGTA T A T C T A C T C G AT G C A T T G G T C T C G C CAGTCACATGGC A C A T G CA T A C A T G A G G C T C T G A G T C TGAGACTGGA A Cnoi C G T T T G G G T G T C A G G A C A T A C G C TAGCCGAt CtGA T T A C G A C G C T C T G A A G A A C A A A T A GanTCGCGTCCGC G T C C A G G A C A C T C A C G G A A A AeAiATCATATTACGGAATGAGTGTGAG T A A C C T G T C C G C A T A G G CGACGACCGCATT A C C T C C G G T A T C T G GATGCAT G A G G A G C A C G G T Gr A A T G C A G A T C T C CTTAGTAGTA G T C G A A G C Go3 T G C T C G G C C C T A A T T G GCCACAGG G A A A G A'- CTTATACCTAAACCGTGGGATAGTCAATTTGTGCAGGGTAAACGCTCAC T A CTTAGGC T'5GTT C C A T A C T C C C C C C A G A G T G G G T TGAGAnieTAcGTCnATGAATT C C A G C C T A G A C C A A A C A T T A A ATTTAGTCT A A T C C C C T G C C A A T C T G G AeAAGGAAATGAGTCAACTAGCAT T A A T A G T T A T C A T A G AGCATGCACTC A G C G A A T T A A G TuGqTTTCGCACCTCACCGGACTACTACAAGATAACAATG A C C C T C G A AGAGAATTG G C C A C CeCCTCGGGTTGTTAAGACCTGTAAGGTACGTTAGTGAATCGTTTGTACTT T T GCACCATGGS C T A C T C G T G A A A T C G A C C A T A A T T A CGTezislato)p 0146269Tb( 5 3 255OQNESDI29394959PeMV P V P V P Vma LCG_MA37LCG_MA4 LCG_MCA5 LG_A6NR R 0 R R70 R R70 R R70A C T A A A A T G T G G C T G A A C T T A T C C G T AGTTAAATCGAGAGTAGTGGCGTATAAGTG G G C T A T T T AG C A A A G C C C T A G G A AGTGTGGCTCACTCCA A AA A A T T G A C C G C A TT A GA G A A CA A G A T T A T T T C AG A A C TACGTTATGGAAACAC A C T A C C C T T C G CA A T G C T G G A A C CGTTAACACTGGGTTTTT A C T GA G T G C G G G T A AC A G T AA G TA A A A A T G T T C A T G TA G GGTATAGGTTTGTTTA A G A T A C G C T G A T C T AC T T C C T C C C AGAGTTGACCTAAT T T C T G T G C TG G A G C T C T T A A A A A T GAACCCGTGCTACGTT G TA G A G C G G A G A A C GT T AA A AA C T C C A G G C A T C CA A AGCAAGAACCCACATC G C A G C A G A G T C A G G GA C A T A G C G G TGACGCTACTTGAA A G A T C T T A AG C A C A G T C A C A G G A T GATGATGCTCGCGCGT A AA G C G C G T T A T A G AG A CA G A AA A A A G G A T A T T G CG A C GGGCTACCCAGTCCAT G A C C T A T C T G A G G CA G G A T T G G G T TTCACAAATGATGC T A A C C G T AG G T G A A T T T C A A A A T A GGGCGATACACGGATC GA G C A C T C T C T T A C TA TT T T GC T G A G T A C T G T TG T A TAACGACCTAGACGTT A G G A A G T G A A A A T GA T C C C A C T C A AGGGGCTTTGTAGA A A C C C A C AG C C G C C G A A C T A T T A G GCCTACGTTCATTTGG TA A C G G C C T T A T A T AA GG C T A GT A T A A A T A T A C AG G A G TTTGCGAAAAGCCAGA G C A A G A T G G G A T AT A G G C A T A A G T GTCGTTAGTTTA A T A T A T A T CT T A G A A A G G G G G G G C C AACAGCTATCACTT T T TG C G C G T G A G A T GA T A GG CA A C G A G G T C C C A T T AG TGGTCACGTAAAAT A A T G A G G G A A C G G A T C G CA A A A T C C T TAAAAGACTA A A A G G A G A A T G G T CG A C T C A C C A A C G ATCATGAGATGT G T G C A G G G GG T G C T G A G A T A A A G A C A ACAATTTGTCAT T A A AGAG T G T A C A A C A A T T A G G T G A A C GTACCGTGACAGTCAAACC A G G G T G C G C A G A T T C C C A A C C C AA T C TGTAGGGTGAAT A G A C T G G C C T A C C A C G G GC G G C T T C A AGTCCGGGAT A A G A T A T G C A A A T GA T G T T G G C G A T T CTCATCTAACAT C T G T A C A C TG A G G A A G G A A C T C T A G G AGGCCCGGAT T C A G TG C T A C G T T A A T C A A A A A G C A T CTTAAAAGAGAGA T C T A G G T A T G A A A CAC C C GA T T A G T C T T G T T TA G G TTTACATGGTAC G T A C A A G A A A A T T A C T G TA A A C C T A A ATTCGCTACG A A A C G A T C A A A C T CnC C C C G G C G A C T T AAAAGTAGAG A C C T G A T T G Coit CCAACAACTTGAGGGTGAAGGAAAAAGCTACGAAGAGAATTTTAAT G G A G T TCAAACGTC A C TatnGeAC G G A G G G A G A G C C A G A A C A C G A AATGTTTGiCGCCA T T T C G A G T A C T T G G T C A G A T C A T CTTGGTACCTT C A T C A C A T C T A C T A A C A A A T A Tr C G T G ACCGAAAACA T A A A A C C C G A G T G A C T T Co3 T A T G C C T G TAGCGAAA A A G G G A T A C T T A T G G'- C5 CCCGATGCGTATACACTGAGTGCTGAACACTGTGG T C G C A T G A C T CCTAACA G G A G A A C T A' GTGGGGATAGGGAACAGTTCCGAGCGGTTATCAGTGGTGCAGAGCAAT T T T T AAGTAGTAT A AnieC A A A A T A A C G T A G G G G T G T G C C T G ATAGTCTcCnTCeGTCTCCCGC G A G T G T G T T G A A A T A T T C A T G C TGGGGGCATAC C T C C T A G G T A A G G T C T T T TuTqAGTGAGTGACGTACAGGCAATGTC C T A G T G A A A T T A T C G AACGTCGGCTA G T T G A T T G G G T TeACATATCGCTGAAATTGTAGCCTAAGTACCCTGTTTGCAGGG A T A A A A C AATAATGGA G A A T AS C A T A G G A A G G G T T C C T G G A A A AGGAGGAGTCTAAezislato)p 9 4 5 7Tb(23973367OQNESDI69798999P V P V P PeMC M MV MVma LG_A7 LCG_CA8 LG_CA9 LG_A0NR R70 R R70 R R70 R R80G T A A A C T T C T G T T C C G T T C T A A C A A C A A TTTAAACCAGTTCGGAAACAACGG G C A C C G A C C C A A C GC T A T A T T A G A A ATCACCCCGCGCCG T T G T A A T GC C T T G G C C G C A C G T G A G TGTCTTCTCCGCACCA TT G A C A G T G T C T A G CC GC A C GA T G C G G G G T T T C GC A G ACGTAAGACCATCA T A A C G T T T T T T G T T T TC G G G G T T C G TCGGTGGCGGATTG C G T C T A T G G GT G G T T C A G T T G G C G C GTCTGGACGCGTGACC T G GT A T C T T A G G C G GT G G TG CG T C G G A G G G A C G T C CT CCGACAGATAAAAT G T T G C C G G A G A T C T G C A TC T G T G T A TGGGGCGCTAGGGG G A C G G C A T G T T TT C G T A G C C T T G T G ATCTCGAGTGTGTCCC T G T T TTAC C A T A A G C T G G G A C A C G C G CAGGATTAACATGCATTCTATCCTAAG A T C G A T G C G G C T T A C T T G GT C G T T A ATGACGATCTGCTT T G C G A C C G C T C A AT T A T A T T T G T G A TCCCTAGCGTAGGTAC T C T A C CA A T T C G T T T C A T T G C G A T T TTCGAAGGTCTCACT G T A G T C T T G T T G T TCA A T C GC G G G G A C A C A T GA G T T TGAGATCAGGACTA G T C G G G T G T T A T T C TA T T G T T G A G T AAAACGCAGAAGGAAC T C C A A C T AG T T A A T A C G G A A T C G C C AGTTGTTAACTCCT C AT T T A G A A T T A C C TT T GG T TA G C C C C G T G T T G T TT T TCGGAATTTTTCTC A T G G G G T C C C T T T T G A CC A T G T A T T ACTCATGGTTCTCTCC C T G A T T G C C AA A T A T T A T C C G G G T G TGCCTTCAGTTCTT A C T TA G T T C T C T A C AA T T C CGT A C T G G C G G T A C C C T GTTCTTTCTGTGAAC C T C T A C T T G T G T G C G C C C TG A T C C A CGGACACGATGGAGCG C T C A G T T A T C T CT T T A G T C G T T G A C TTCCCGTCGCCGTA C A T T G AC C T T G G C C T C T A G C C C G A A G CCCTGGGCATCGTTT C T C T T C T C A T A T A CGC T TA G A C C G C C T A G C T GA G TTTGTTATCTCC T C C C G T C T T C G G C C C G A T T GA A T C A T T CGGACCAGAT T T C G C G G A G C T G C T T GC C T G T G A A A C G CTCGCTTCGA G T G C G G G T T C T GT C T T C A G A C G T A G A G CAGGACCTGG A T T G T T T TA T C T G T A A G A G G T C A C G A A GGGGGCGCTGGG C C CTAG A T T A T A T C T A T G G C A T G A A T G C AGATTTTCTCTATTACT A T A C A A A T A T A C C G C G C T A T G T T GC T C ATCTTCAACT G C T A C T C C G T G T A G G T T C C GA C A T G A T ATGAACTCTCAT C G G A G G C C T G C C T G TT C A T T C G A A T T T TCGCTCCTAG A G T A C G T G T G GC C T C T T G A C C C A T T G C AGAGTACAAG C T C T A G Tni T T G G G A A A C T C T C C C G A C C C GCCCCGTA T A T Tot T C A T T T A T T G T G G T G T G T C A G G C CGGCGGACTCtGnTC G T T G T A A A C A TCa A G C A C C C G A G T T T C T TeTACGAATT G A C G T T T T A T C C C C A T C A T C G T G TiTCTGCCCATGGAATTAA T A C G A A C G G G T G A G C C A A C T AACATGGGC A T G C T C G T G G G G G A A T T Tr C A A A T A A A G TGAGGCTT T C A G C G A A G C A G T C Co C C C C T A T A T C G A AGAAACGC G C G C C T A C T C C C'3- GTCTCGCGAGTACATAGTGGTCTGCCTTGAAACTGGTCCCC C A C A A G C C GGCGGGGAG G T T T C T'5GniACTTCAGGTTTTTCATTGGAGAGGACGGGGGCCCATAGATGTGTAGCGTAAA T C GGTGTAACGAeTcATnGTC A C T G A T T G T G T A G C C C C G C G T T G T C GCTTCGGAGTA A A C A T A C G T T T G C T C G C G T T C AeAuATqCATAGGGATTTTACAGGTG G C C C C C C C G C G G T G A C T A TAGTCATGG T C G C G G C T T T G A A C C CeCGATAAAAACCTATGTACCATACATTTCTACGGATGTGAAACGCG T T T C G C C T G C A A CACTAGTGCCTTGCCG G G G T G T G G CCAGGAC G C G A G A GS G A C G A G T A T G A G T G T G C T G G CGAGTGATCCAGGCAACezislato)p 081Tb(2632OQNESD0I01101PeMV P Vma LCG_MA1 LCG_A2NR R80 R R80G G T G T C C T C C A A T T G A A G T A A A G T T G TTATTGGCTTCTTGGCCCGGTC T T A A C G A T A A A A TC A C C G G G A T T AGATACGGGTAT A A T G T G T AA T C G G A A C G A A A A C A ACGACACTTGTCTG A CT A G A G G T C G G T AT C AG AG C A A A C T T C T T A TG CTGAGTACGTACTG T T G G C G A G C G C A T C A TA C T G G G A TGATGTTATGTT A G G C T G A C G T CT A A T G A A C G T C T TGGCGACTGTCTCA T A T A GG G C C T G A G G G C T T A A T G T AACTTTGCGGTTG G G T C T T T A A G A T GTT A T C TG G G C A C C A A C AG C A C GGTCGCGAGGCT G T A G T T C A G T T T A TA C C A T T G G A TAATTCAACAGGGC T T A T C C T CC C A G T T A A G C C G C A A ATTCAACTGTTA A C TG G C T G T G G G T AG T T AG GC G C C G T C A A T A A G CA CATACTAGTGAGAA C G C T A C G A A C T G T A T CA C G G A G A GGTTCGATGATC A T T A G A T A C T T GT C T C G G C G C A G T TTCAACTCTA A T T G C C T AC T C A G A C T T G T G T G G T TGAGAGAATGAT C A GAGT G G G G A A A T A T T G A C A T C C T GTTCTCAACTCTTTGTGAT A A C C T A A G T G C T T T T A C A G GC C C A CCGCAGACTG G T T A T T C T A T G C T A G GT T G C C A G G GAAGATATCCCC T A T T T A T T C G GC G G T C G T G C G C G T CCGTAAAGTA A G T A G A AT T A T T G C T C G T G C G G C C CGATTAAATCGT G CG A T A T T T C T T T TA T TTA G G A A T A A C C A C T GACCCTCTCTCGC G A T T C A T T T G T C C A A A G C AG G T T C GACGTTTCAT A G G C T T A G C A T A T T AT A A T C G C T G AGTACAATCTCC G T A T A A A A A AG C T T C T T C T T G C T C GGTTCAGATA A A G C A AA T T G G C T C C C A T T T T T T A GTAAAAATAAGG TC G G T G T G C G A C C TA AT G GG C A C C A T T T T A G CC G TGGAGTTACGAA G A C G A T T T C C A T T G G A GG A C G T G T ACCAGCGCCG G A C T C G T T C T T T GT A C T G A T C A G C TTAGGCTTAGTA G A T A C T T GT C C C T C T C G A G C C G C C ATGAGTCTTT A C C TACT C A A C A C A C G C C A G C A G A T CTTCAAAGTCGATGTTACA G T A G A T C A G G G T T G G T T T G T GT T T CACGTCAAATAA G C A A A A C G C T G T C G C GT T C T G C G G GAAACCTCGT A G G T T G A G G A C CA A G C G C C G G T G C GTGCTACTTATT T G T A C G TT G T G G C C T G T T C T G A G T CGGTTGGTAT C T CC G A A T T G T T A GA C T GTT C G A G A C T T T G G T C Ani CGTCCCGC C T G A A T C G T G G G T A G A T A A G Got A C C GACTTCTGTG C T C G T T A G C C T C G G T A AtG G C T C C C CGACAC C G A G C A T T T A G T C C CanTeCG G C C C C G G AGGAATCTAA T T C G A T T A A C TiTATCAGCAAGTGGGTGTGTGGAGACGTTTTCCTACGGGTATAGTCATGAGTATTT A A T T A A TGCTTTATCAACAAGA G A CTTTTCC Tr C A G G C T T G T C T TG To TC T G A A T A A T T A T A T'3- TACAGTCTTCC A G G T A C T C G G T T T T G A T A A T TTGAACTAA A G C A C G A A G A T A A T A T G T'5CGAGTCTTAGAGCAGACAGAACT C T A G C G G T T A G A G A GCTTCGTTGTT G A A G C A T C A C TnieTcCGTCGCTGAGTTTGGGTCTTTTGTGCGAAGTGTTAG T C C G T A C GATCAAGTATA G G G TnGeTAACCTAAACGTCAACCCCTAACAGCTGTCGCGTAATTCGTCTATGTAAA GGCCTTTCuCqGC C G G T T G G G T C T C G G T A T G T G C A A T TeTTAATATACCG C C A T G A T A T T G G A C T A A C C C T TTTGC G G G T G G C T C C A A A G A T G T A A CS A A G T TAGTAGTTTGTGATAGTCCTCTCTATAATTCCAATGATAGACCGTezislato)p 7Tb(37OQNESD2I01PeMV Cma L _ 3NGRAR80C T G C T G T C A C C C C C C T C T C C C C A C A T C C AGATTGGGGTGTACCGACTTAT G T T A C C G G C G C C A A TA C A G T G A A G T GCGTTCACTCAG G T T A G T C A A CG T A C C G G C G G T A T C T AGGAGCCTTCAGGC G A G CAGT T G G C T G A C C C A C C C G G C A G ATCGAGTACCGTCTTCGGGGGAC G T C G C C T C C G T G C A C G C C G AG C T G A ATTACGGCGGTT A G C C G G A A G G T T A T CG A C T C T C C T G ACCTTTCGTTTTTT C T C T T G T G CG C T G G A A A A A A C C C G T CCCGTTCCCCGG T G C CG T G A A G C A G C CA C T A TTC G C C A C A A G G T A G G C GCCCTGCAGATCC C A T T C T G C G C G G T G A G C T C CT T G C C GTCGAGAACTCTTT A G T T A A T T A T T T T CG C T G G T A T C C A CATCCTCCATCC G A A T T G G A CG G T G G G C C T C A T C C G C GGCGATCACGAGGT A C TT C T A A A C C C C A GT A A AC CT T A G C C C T G G G T G G AT GCTGAGGCCTGCGT C C A A C G T A C G A G G G A A T AT A C A G C G GTCACGGCCCCC T G G G G C T T A C C A CG T C G A C G A C C G T GGACGTGAGGGGGC C A T C C C CT G T A G A G C G C T T A C T T T T GGAGTCTTACCC G CA A C C T C G A A T C C GA A CC A CC C C T C T G G A A T C A CT T CGTAAACTGGAC C A G A C C T C G G A A A C G A G GT T T T G C G TTCCACTACCGTCC A A G C C G T T G A A AT G A T T T T C C C A T G TGGGAGGGACAGGG T T G C A CC A C G G C A A G C T A G C G C A G C GTATAAACGCAGGAT T G G T T G G G A T C A C TCC T A TC A G C A G T G G A G CA C C GGGCCTGACTGGTC C C T C C C T G C T A T G A T CT T C G A C G T T ATTAGTGTCCGC T C A T C A A G A T AA A T C G A G G A G C T A C AGACGGTGGGACCG G T A T CC G G G T C A T C G G G A C C C G C C A CTTACGGACACTT G T T A A G C C A T T A C GTC A G C GC G G G A G C C T A A GG T A G TGCGGCCTCGGGAC A A T A G G T A G G T A A A TG A C T C G A G G A CGCTAATCCCGAGG A T G G C A A G CA G A C T T C T T A A T C A G G GACCGACGCGTT A A G TG C G C C C G T C C CG C A T TTA G T T T G G A G T C T C C T CCGTATGACGTGG A T C A T G C C T A G G G T A A C A C GG C C C G CCTCCTTGTCACTG T C C A A A G C C A A A C GA C G G G C T C G G C CTCCCCGCAACA G T C T T G A T CC A G G A C C C T A G C G A T C CGTGGCGAATAATG A G GC T G A G T C C T A G TT G A ACG A C G C A T G A C C A A G ACGTGTACCCCTCGA T A T C G T C G C G G G T G C A A G CT G T G G A GACAGCGCCTAC C T T G G A C G A C T C G CT G G A G T A C A G G CTCTCCCGTTCGAG T T C G C A G Ani G C G G G C C C G T G C G C C C A GGTCGCATCA G G A Aot G T G G T C A C G C G C A G G C C G C A G TCCTTGTCCGGatGnGCeACG T G C G C T T G C C G A C C G G C A C T T A G GTAGTCAGGATGT T T T A T T C T C A G C G A C C C A TiCTCGTGCTACCCTTTTCTGTGCCCGCTTT C C C C C G C T G G G T T GCTATCACGCA T A C G C A A G C Ar C G A A G C C T T T A C C T C TCCGAGATCT A C T G A Co T T A A G T C C C G G T C A C C C G T TGTATGGAGGGA C'3- C C A C G G G T C A T C G A C C T A G C C A T T CCACA'5 GTTTTGGAGAT C A C C C T G A T T T C G G G C C C C G CiC C T G CCCCGCGTGT G C G G A C C C A T A C C C G G TneCcCA C A G C G A ACCTCCTTTACC C C C G C T C T A A G CnATCTACGCCGACACTCACTAGCTTTTATCTTCTCCCCCGTGA T A C A T A CTCACGCACCATC T CeAuGT T G G C C G G C T G C T G A T T G C G T G GCGGAGAqGTCTTGAGAA C C T C G T G C A C G T A C A T T A T G CeTTCGCCCCGGGGGTAA C A A T A T T G T T C T G T G A C T C T AGGACCG C T T C G C A C G C G C A A G T C T GS C T T T T G T C TACGTTCCCTTGTCCCTCTACCGAATTCCTGTCATTCACTGezislato)p 35516Tb( 9 569OQNE30405SDI 1 101P V P V PeM M MVma LC_NGRA4 LC_CR80GRA5 L _R80GRA6R80A C A A T T A A C A A A C G T C T G G C T T G G A GGAGAGACCATCGGGCTATT C G T C C C A A G C T G AT C T A G C A C T TCTGGGTGGAAT C G G G T C A CC T A T A T G G C T C T G G CGTCTAGTCGAC C A GG G T A G A A G C CC T G GAC G T A A T A G C C C G A GAAATTTGAGCCG A C A T T T G C G G G C C T G G AC A T T A GGGGGACCGCCG T T C G G T G C A G T CT C C T T A T G C G AGACCGGCGCCTGT T C A G C TT A A C A G C T C G T C G G T C TCGTTTCAGAGT GC C A C T A G G C T T CG AT T AT A A C G T C G T G G AT G TATCCCGTTTCC C T G G C G G G T C A C C A AA T C T A G C CGTAACGGGATC A A G T C G C G C AC C G T C G A G C C T T GGGCCGAGGGTC C C G C TA C T T T A A A T T G G C T T C C TATGGCTGTGGAG G A T C C C T C T G A ACT T G AG G C A T T G T A T GC G A TATTGCTGTCCGAG A G G G A T G T C T C G GG A A T C A C A G AGACCTCAGGTG T A T G C A G GA C A T A A G C T C C T G G CTAACGCTAGTC G G TT C T A C A G G G AG G G CGC G G A C A G C G C A G T GACGTACATTATA T G A A G G G G C G A G A A A A GC A T C C ATTCTGAAACTG A T A G T C G T G A G GC G T C A C C A G A CGTCGCCCGTCG G G G A C G CG T G A C G C A T G C C T C T TGGTAGTTCAGG T TA T T A T G A G C A C GT T CC G GA G C C T A T C A G T GA T AAGGTGTGTTCC C C G T T T T C G C C C T G AC C C T C C T CGGGAGCACGGT A G T A T A T G A GA T G G G G T C G G G C ACTGGGACTGGC C G A G ACGC G A G G A T T A G A C G G G C GTCAAATCGTGCCGTAAAATAGG G G G C C T G A T A A A C C C T A GG T G G TCTGATCTCCAC A G G C C C T G C C C G TA T T T G C T G C CCCGGGTGTCGC C A C G G C G CT C T T T G C T A T A G C C GCTCCCGTAACGGA T CC C A T C A C G C C TA T TC TA G T T C T G C C T A C CG TAGAGTCAACCT G T C C C T C A T T T G G T A TT C T A T G CTCGAACGTTCG G C G C A G T G T G CT A T A G A A C C T C TCTGTCAGGCTA C T G G T TC G C C A G T C T T G G C C C G CGGTTTCACTCA CC T T T C A T G C A A GC GG A TG G T G C T A T A G G TA T ATCTCTCATA G G G T G A T T C C G T C T G C TC T A C G C GCCACTGTGCTT C C A A G T T G C T T CT A A T A G C G G G T TAGCGGTCTG T A C T C G A TG A T T C T T A G A G T T T A TTCGTCTCGA T G C TnG G T T C T C A G C G A C C C C G G T AAGCTAGC Coit T T A G T T C C T C T C G T G T A G A A T T TCAGTatGnTAeCGA T T T A C C G C G G T C C C G G G C T C G TGACTCCTC T C T C C G T A G T C T A G T C T T TiGTGGTGGAAAATCTGCGC T A G G A C G T T G A A C G G C AGAGAAC G T C A T T C T G A C A T T Cr C T T T T G T G A GAGACG C C T T A A A A G A C C Ao C T G A C G T G C G A GATCCA T C A C C C A C C C T'3- CATCGATCTCACCGACTGACACGTTCGCTGCGCC C G C A C G C T TATCG G T G G C T G C'5TTAATCCCCACCTTGGTGGGGGCACAATTGAGGTCCTGTA G G A C T GGTGGTG C T G TnieCcTTAGGTTAACGTAAAGTCCGTCTGTCCCTGAAGACGAGGTGTTGCAT A TACGCCATnAeTG T T T A C G C A C C C C T C T T G G C G C G G CuTTqCTGAC C T A T T G C C C G T G C C A G C C C A C TeTCCGCTGTCCCCTC T C C T T C T A G C T C A A G A C C C AGACACTTCTGAC G C C T C A G A G C C T C T T C CAGTA T T A T C A A T C G G G T G C CS C G A T C C T C GCGAGCTTGTGGACCGGACGTGGTTGTCAACCTGAezislato)p1Tb4(31OQNE6SDI01PeMV Cma L _ 7NGRAR80G C A C A A C G C G A T G A A C C T G G A C T G G G GTCAGCCAGAAGATGGTTCAGACGGATC T G C G T C A C A CG A T G T G G G C C G C A ACTAAGTCCTCAGCGG C G TT G A T G A A A C C G GA T A CC T T GT T C G C G T A G C T G GG C G ATTAAGGCCCTCGTCA G T A G T A C T G A C A AT T A G G T G T T A GGAACCCCTACGTCAC G G C A C GCGT A T G C T G C C G C G C C C C GCCTAGATCCAGTACGTCCCGAGTGTTCG C C T A G T C T C G T C C G T T C GG C G C G G TACAGCTAACCGGC A C G A G G G A G G G TG G C G T T T A T C C T AGACTCGGACCTCA G C A A A TG T T C C T C C C C G C C C T A C T ATCTCGGCCGACCCT C C G T T G T G C T A T C AGT C C A G CC G C C T A G G C A TT T A C A ATTAGGTCGCTATG G G C T G G C C T T T T CG C A C G A T A C A C CAATAAGCCCGTCGAG G C C A C CG T A C A C A C T G C G A C G A G T CTCGTCTGAACAAAA C C G G G C C G A G G A T GGA G C A T AG T G C G T C C C G TC C G C C GATCCTCGAACTTT A C A A T C T C G C A G AG C G A C T T G C T G CACCCGACGCTGAG C G G C G G GC C A C G G C G C T T C G G A T A AAACGACACAGG C G TA G C G A T G T C C G TT G A CT AG T A C A A C T G A G A G C TG GGGGGGTCCTTC T C T A G T A G A G C C G G G T A G TG G G G C T ACGTCCTCACCT G A G C T A G G A G C G A CG C T C G T T A G C G CCGTCGGTGCCT G T A C T C A C GA G T C G C C C T C A C G G A T AGGGGCCATGAAGG G A TG A C C G T T G C T G CT G G TGG G C C C G T C C A G C A A TGCGACAAAGCGA G T G T A C A C A C A T C A G A G G A AG T T A T ACCGTTGGGTCC T G G A G C G C T G A G T G CT C A A C C G G T G CGGCGATAAACACA A G G A G T C G AC A C A C T A A A T A A A G G C GCTAAACGGTGT T G T TC C T G C C G C C C GC C A T TGA A T A T T T C C G A C C G C CGGTCAGTAGCCA C G A T C G C C A C C G A A C G C A G GT T C C T ACGCGGGTCGGCAA T G C G C A C T G T T C A TA C T G C G G G T C A GGAACGTCGACG G A A A G C G G TG C A T C G G C C G G C C T C A ATCACCACCCAA C G A AGAC C G C T A A T G T C G G G C C G T G G AAGCGACGTTCGCCGTAAGTGGC G G T C C G G A G A C T T A A T G T C TG T C A T GTGTCGAGACTT G A G T A C T C A T G G C G AA C T C T T A A C T GCATGCTGTCAG C A G A A C T G T CC T C A C G A A C A T C G A A TCCCGACTGGGC C C G T CGGC C A C G A A A A T C A C C C A G C A ACAGGTTACTTGAGGTCCCGGGT A G G C G G G G C T C A T C G C A T C T GnT C T G GGTTAGAGAG G A A A T T C G C G G G C T C C Aoit TGCCCTTCTGTCCGGTGATCGAACGGCGAC C G C G A A G G T C C C CGTCGGGTG C G C G A G T T G T GatnAeGGGTCTGAGGGGGGGCTGTGTTCACTTTAAGCTACCATTC G A T C G G C GCCGTTCGCCT T A C GiAAACCTGGGAACTCATGGGACCCCG C G G C A T T C A GACGGAAGGACrA G T T C A G G A A A T T T G ToA3 GCCCCT A C G G A C G G C T C C T C G A C C C C G A A G'- G5 ACAACCAAACAGCG T C A G A C T A A T A A C A A A C T C C ACGCTTC C T C T T T G G G G T C G A G T C C A' C T C C G A T TCACGCTGGG A A G A T A C G T G G C C T AiT C C G A G C G A A C TGACAGTA G A C T T C T A A G C AneTcCC C G G T G T C C T C C T CCCGACGTCC G A A G A A A TnGCCTTTCGTGTATCGCTTCGGTGCATCCTGACGGATGCTTCTCTGC T G A C AGGGGGTGGTC CeGuGA C T G T C C T C T G G G T A G C A T G G T T T CCAGGqGGGCTC C G A A A T T G G T T G G G A C G T T C A T A GeTCACAGCGAACTACC G G T C T G T T T G A G T G T C C G A C TTGAAGAAA C C T A A G A G T C C T C T G C A CS A C C C C A G T CCGGAGGCGTCATGATGGTCCTTCACACCTGGTCTAGGGezislato)p 20Tb(09550401OQNE7SDI08109101P PeMV MV P MVma LC_NGRA8 LC_CR80GRA9 L _R80GRA0R90T G G A A C A A T G A A A A G C T G T T A T C T A G G ACATCGGTGACTATAACATAAAAA A T G T A C C G A G C G AA C G A G G T A A A T AAAGACTGGCGACT T G T A T A AC C T T A A A G T T A C T C C A T TCTCAGAAATGATA GT G G A A T A T T A T G A AA AA T A GA G A G G C T A T A A TA A A AAGACTGTCCGTTC T C T C G A G C A G G T C C AA T A T T T A G T ATTTAGGCATATTT G C G A A A A T CC G G A T A A A T C T A G C C CAAAATATTGAGTC A T AA G A G T A T T A A G AT T T AT TT A C T A G A T C G T G T GC AAATAAAAGGGGAT C A A C T T T C A T A A T G A G AA A A A C G T ACTGTATCGGGATC C A A C C T A A C T AT G C A A G A C A T C T G TGTCCTAGTAGCGT T C A A GATG A T A A G A C A G A C A C A T T A GTCGGGTCACTAGAAACGTGGAGAG G C A T C T T T C A C G T G A C G A AT A A T A GAGGAGAATCCCCC A T T C G G A A T G A G TC G T G A G A C G G G TGATTGTTTAACCA T G A C A T TA A T A A T C G A A A C T A T T T CTAACTAGTGTAAC TA A T G T A A A C C T A A GT AA A C TA G A C C A G G A A C GC C A GAGTAAACAGGGTT G A A A T T C A C A T A C C AA T T A T G G T G ATAAGTTACCTTTA T C G A A A A A AG G A A T G A T A A T T T C C CAATTAGATGGCGT G T CA A T G T A G T C G C AT G A TG GG A T A T G A T T G T A C TA TTTTTTATCATTCT T T C T C T C T C A T G T G A T AG A A T A T G TGATTCCAAAAGAG G G C G T A C A A G CG A G T A T A C A A T A A ATCTTTCCTAATAC C C T T TACA G A A A A T A G A C T T A T T G A TCCGTAGACCCATCACCACCAGTAA C A A A T C G C G C A A T T C A T T AG A T A G AATTATAAATTTGT A C G T C T T C A C A C TG A A C T A T A C C G ATCAGCTACGGTGG A A A G A A CA A A A T G T A G T T T T T A T T A AGATTCCTAAAG T AG C A A G G C C G A G A TA C GA AC G C C C G C T C A C C G AG ACTGAAAAGCCAGG C A C T T T T T T T A T C A C T A CT A C A T G A ATCAGCCTCACT C G C T A C T T A G A A AA C G A G A T G G A T T TCGCCTGCTTTA C T A A A T G GA A T C T A T G G C A C T T G T T TAGTTCTTTCCA A A AA A A A T A C A G T T AG A C CAT T C A T T T C T C A T A C TGAACAGTTGCTG T C C C G A T T C T T G C A T C A A A TT T G C G ATTCATCATGAG A A A T C C A T T T G T G G CC A A A T G T A G C GACATCATTCTG A G C T T A G T A CT A T T G A A G A T T T T T C TAACACCTCTCT C A T T TG C C A A A A T T T A G T T T C C T A T TGTTTATGTCTAA A A C C C T A T C T T A C AGnA A AT T T G A G T C T T C Toit GAACAGCGTTAATAAAAG T A T A T G G A A A G C T T T A G T TGTCAACCA A A T T A C G T T C A A A A C GatnAeATATTTACGAAACCTAATGAGAACAGGTTAC C A A G G T T T G T A TTAAGTCAAGA T T T G T T A TiCTAAGACTTTAGATTAGAGAAATAAACTACCGAGGCTGGATAGATCGT A T A GTTGAGAGAACr C A A G A A G A T A T G T ATo3 C TC A A T C T G T T T A G T'- C5 GCAGGGTACAATGGT A C C A A A C A G T T C T C T C T A A TTACGTTTG A G A C A A C T G A C A A T T A T' A A T A T T T A TACCGTTGTG A T T T G A C T T T T C TiA C G G A G A A A A T C CAGGATGTTA C C G T T T C T AneAcAA A A G A A G G C G A T A C T GGCGAAATAT T G T A GnAGACGTTTGAGTAAGACTCAGTTCCCTCGATTCTCCTGGGGTCACTGATTAG T AAATATATeTuAGqGAT C A T G G A T A A G A G T T G C A G C T C G A T CAAACAAGT A A G T A G T T G T C A A G A A A T T A T CeCAGAACGTGTAATAAGAAT C C T C T A T T T T C A G T G T A C TGACGTA G T C C T T C T G C C A A A A T TS A G T A G G A A A TAAGGAGTTTGAACTCGGATTTGTCAGTTTTGTTATGezislato)p 53Tb(69627301OQNE0SDI11112111P PeMV MV P MVma LC_NGRA1 LC_CR90GRA2 L _R90GRA3R90G C A T A A A C G T A G C A T A A T A A G C TTCAGACACAAAACATTTAAACCCATTG A C A A T TCGA T T A C A C T T T A A GAAAAGTGTGCTTCAAGTTTGTTACACTA C C G C A A A G T G T T AA T T C A A CCGAATATATGACACA A T T G A TGAG T C T A C A T C A G A CTACATGGTTCGATCAAAACGTCGGATCA A C A G C A C A A C T G CA T G A T T TTTACGAATTCCAAGGGA G T C T CGAA T A A C T A C G C C C T GAGGGCTAGCCGATGAAGCACTTGTT G T A A T A G T T T A A T C CT C A C A ACATGAACGAATTC C C A A A C G G TG A C A A A T T C G A CTAGTGGTTTTTTGAT A TA A T T T C T A T G AC C CG A GA A A G T T A A C A GT G GTTCTCACTACTTA G A A A C A C C T A A TA T A T T T A A ACTAATCACGGTCC T G G T C TAAT C A A A A A T G A T C T GACGTTTAAATAGTAA TAGGGCTGTT T A G A T C A T A T C T C C T CT C A T A TGGAGAGAAAAT C A C T T C T A C A AA T C G C C A T G A ATAGGATAAATT A T A A A TA T T T T T G C T A T A A A G CCGAAACACTGG TT C C T G C T C C A A TA CT G TC T G T G C A A T C GA T ATATAGTCATCA T C G G C A G T G T G C G TT T A T T A C ATAAGGGTCGTT A A T T T A T T TT T G C T T T T G T G G AACTTTAACAAGTA G T AA A T A A T G A G CC A A TAT T A C T A A A C C C A CGCACAAGTTGAT T T C C A A G G A C A G G T C TT T G T T TACATCAGTGGA T A T A T G A T G T AT T A T T A A T A C GCACAAATGTAATA G T T T CC C G C T A C T G A C A A T A C TACAAGAACACCT G G T G G A T A G T G GGA T T AC A T T G A C G T AT T T ATTAATGACT T C T A G A C T T C A A A T GA A T T T T T ATAAAGACTCTG C A C A C G A C T AG T A A T A T G A C A T AAGTAATTTT T G A G A CA C A C C A T T T T A G T A G A CTTCATCACA A GC T A T A G A G T T AG C GAG G G T A G T T A C A T GAACATGACGA G A A A A G C A C A T G T T A A A AG C A T ATAATTGCTA G A A C C C T T C C G G A CT G C T G T A T TCATGCCTGA G A T G A C A T C TC A A A A A T T C G A G TTCTTAGACT A A G C T GT G T C A A T T T G A G G G C T ATCCAGTGGCGT AG A T T C T C T A A G AG Ani AA T C T T A T T T T T Aot CCtTGAGAGTTC T G T A G A A C C T A T T A A C A T ACTCTGA T T T G G T T C A C G T T C C A TanG G A G G TGAATCTCTA A A G G A G A A C T C A AeTiCAGCATTTTTAGATACGGAATCTCGTAGCGATAACATTGG T T T C G C C G T CAAAACACCTACT A T A G C T GCATC T T T G A Gr G G C T A T T G T G T C T C A A T CATGTTTC C A Go3 T A A T G A T T T G G T A A T T T T T C CAAACC T'- T A T T G A T T A T A T C G A C T A A T T A ACTCG'5 TTA C C A T A A A T A C C A A C T C A C T A G T GTATT T G A T A T C G G A G C T G C T G T G A C GnieTcAATnTCTTTGG G A A G C A T A T T T T G A G T A T C CATTAGT A T C T T G G T G C A T A A G C A TeGGGCGTTACTAAATAAG A G T T A A A C G A A T A A G CATAGTACA C A C G T A C A T A C A GuAqTGTTCAACTTCACACCTTCACAACTGA A T T C T C T C G A ATAGGAC T G G T T C A T CeCACGTTTTTGGTTTAAGAGGATTCCAACGATATGCG T T T A G A GAGATAT T C G T AS T G T T G G T A C A T G G G C G A C AATCAGAGAGAATezislato)p 3 0Tb(7600405OQNE31415SDI 1 111P P PeMV C V V _MC MCmL 4 L _ L _aGA A5A6NR R90GRR90GRR90T A G G C A G G A T T T T C C C G G G A C G C C T G C A GCAATAGACGCCCGAAATTAATCCGT T T A A T A C A T T A T AT G C G C A G G A C T A TTGAATCTACCCTT T G C C A T GC A G T A C A G C T T A C T A G A A TAATCAACTTCATGGAT A A A A T T A T T A A A C GTG A A G GT G A A C A C T G T T CT A G T TTCAGTACGACGAT C C G G T G A T A A T T T A T CA A A A G T G A C G AAAGACGAAACT A A A A G A G C T T AC A G A T T C C A T G C G G A CACTTGTACGATCC T A C A CC G G G G C G A A C C C A T T G A A T A A CCATTTCGTCATT A A G T G G T G T T T G C G AGG A C A AT A A A C G T C A G A TT A G T CTTGTAATGCAT C A T G A T T C A A T T G A T A CG A T C A T G A C GGTGACTCTAAAAC A T A A C A T T G A TT A C T A A G A G A A G C T C AGTACCGCGGAA C A G T T TC G C A G C A A G C A A A C T C T T A T ACCACATTTGAATTG T T G A A G T T T A G A T ATT T G GC A A A A T C A A A C C AC G T AATTTGCCAAAGTA T G C C G T A G T T T A A A A C GC A A G G C G C G GGTTGTATACTG C T T C A T G C T G G TG A G G A G A C A A T A T C GGGTAGGCAGTAAG A A G T G AA A G A G T A T G A A C A T G T C A T A AGTACATTTAGT AA T C A T T G C G A T C A T GG CT A A GA C G A G A G G G T A T CG T T GAGATGGTGACG A G T C T T G T G A A G G T T G C AT A G A A C T C GCGAATACTATGGT A G G G A A G T A A C AC T T A T T T C G G T T G G ATTGATTGAATT T T T A C A GA A A A G A T C A G A A A A G T C A A CTTGTTTTTTTTCA AC T G A A C C C G T T A G TT AT A TT A G G G G T C A A A T A CT G AGACCCGACAATCC A G T T C A G A G T T C A C A G T TA G A G G A T A GCGTATTGATTT C G G A C T A A T C A C TC T T G A G A G G A T C A TCCCTACAAAAAGG C C C T C A TG A T C C A C A A C A G A A T C T C G ATATAAAGATTA T AG G C T T C C A G C T T C TT T GA A CC C G G G G A C T A G A T TC G CGAGGGGCTAGGAT A G C T A G A A A A A C T A A C T AT A T A A G A T CCATAACCTTTCTT A A A C A C G A T A T TG A A G G A A G T C T T T C TTGAACAACACA T G C C A C AA G C A A C T G C G A A A G G T T A A ACGACAGACGAAAT CT G A C A T G T A T T T A TT AC A CA C A A G G A G G A C A G CG G CCCACGATCCCTCC A A G T C G C G G A G T G T C A A GA T T T C A C A GACTACTGAAAT G G G T A G G G T T A C GG G A G A A G A A C T A T CCCACGGAAAAAGG T G T C A T AG A A T C A C T C G A A C T C T T T G AAGCTTTAGGGA A GG T A C A T A T C C T A A TT A AC A GA C C T T A G C A C A G T TG G TAACTACCTGGC G A C A C C C G C C T A T A T G A A AT A C T C G C TTGCTTATATAAAT T G G G C C T A T T A G Ani C C A A T G A C A A T G C TCGACGCGAG T A C T C A A T Tot AAGGGAAAGTGTGTCTTGGAGTAAGTCGCAAGTCCGTAGGAGTTTCGATAC A G A AAAATCTTT TatnCeATGC T C C G A T T G T T T A A G G T G G C G C T TCACTiTTTACACGGGTTGCGGGCT C C A C A T C G A A C T T T G A A A A CACGCGCGAAA C A T A A T T C G C A A T A T Tr T T A A G C C G C A AAGTCATGTA T A A G A C C G T T C Ao T G A G G T G A G G A G C G CCATTGATCGGT A T T T T T A'3- C'5 AAGATATGTCCGGTGAGGTGAAAATAGGCTACTCGAAAGAAACTAAAACTCG A A ATCCTTAGGA iTGTCCT T A C T C A A G A T T T A C A A C A C T T T G AneTcTC ACCGGGTCGAGT C A A T C T C G A A G G A G T A T T AnACCAACTACTGTTAGGTGGTATATATA G A A A C C A G T A A T T A ACGTGTGAAGAAT C G A T C T G G C AeGuGAAGGCGGTATTAGAGTCGAAATCACTGATCTTGTGCAGATCGAT C C A A T CAAAGAGAACTAT AqAeAA A T T A T C G A A A C T C G T C A T C A A A T CCATACTCCGTCGAA A T C G A A C T C T T C G C A A G A T A A AS A T C A CAAACGGGGGCAACCCTGGTGCTCTTTAACAGCAAAGACACTATGACAezislato)p 2 471Tb(340851OQNE617 8SDI 11111P V P PeM MV Vma LC_CNGRA7 L _MCR90GRA8 L _R90GRA9R90T T T T T C T C C C T A C T T T C T G T T T G T G TCAAATGGTCTACCTTACCTTAAACT C A C G T G T C C GG G G C G C T G A A C A GGAGTGTCAGACGTAT T T GA C G T A T T T A A AG A C AT A AC A C T A A G G A G C T CT C CAAAACCAGATCTC C A A T A G C G G C A A A CT G G T G G T T TAGTGTCGTGATCACA A C T G G G AG G A T T A A T T T G C A T T TCGAATCTTGAACACCA A G A C G A A A C T C A CCC C T A C GA C T G G A A G T CA G C C T ACGTTACCCATTAA A C C G G A T A A A TC A G T A A G A G T C CATAGCGCCTATTCAA C A C CT G G C C G T T G TA A G C CG AG A A T A T A A A A A G G AA CGTCACGTTTTACACC A T G T G C A C A C G G A CG A C A G T C G T TAACAGGGGATACC G G G G T C A TT G C C A C A T T C G C C G T GTATCTGAAAGATA A AC A T C C T A C T T G CA T AT T GT A A G A G T T A T G A CA C TTCAATCTCCGCTT G T C T A G A G C G A T G T CA A C C C T A T TCGGATTTATTT A A G G T G A T T TA A C T G T A A A T A T T CGGCTAATTAACAA A G C AC A A T A T A T C TC T G C GCC T G C T G G T C T T G T C TGCGATCCCTATCAA T T T T T T A A T A G T T G A A AA A C T C A TTAGTACATTACAA C A T A G A T G C A CA A T C T A A C A A A T ACACTAAACTTGTT A T T A CG A A T T C T C T T A T T G C T A G CCCTCGACAAAC TG G C T T A A T A T A G TC CG G CG C A C G T T T T G T G TA G CTTATGGGAA C C G T A T G C G A T T T A A C T GG A G C G A GGGACGTTCCGG T T G T A C A C G G A C TT A G T G T T T A T G TTAAAAAGGACC T C G A A A A CC A T A A T C C T A T A A A A T TTGTTCTTTATC A A AT A A C A A C A T T CC G G ATC G G C C T C A T T A A G G AAAGAACTCGAGT T A C T C T T A G A A G A A C T A A GT G G T A GCTGATTTACTA C A A G C A G A C G C C C GA G A T G T T A T C CATGTTTTCGCT A G G A A A T A GT T T C T T T G A C G T A G G TCTTATATCT G A C G GC G G T T C T A A G A T T G A C G A G ATCATAGCGAGAA T A A T T A T T A C G A GTG C G CC G T G T C G T A G T AA C G CCGTACACTCCG T T T T A A T A G T T A A A G CT A T T G C T T AACTCCTAAGTT A C C T C T C A G A GC C C T T G A T T G C A A TTGTAGAATAAT A G T G G AA G T T A A G C T G T G T T G C T G TATTCAAATAGA CG A C T G C A T C G T T AA AT C GA G T T T T C T A C T C AC T ATTAGAGCAA C A T G A C A C A G T T A T G C A GnG A A C G A CTTAACTATT C T C T A T C A C A T G G Aoit TGTCGATCAACTTATAATGATCGATCTTTTGCAA A G A T C C C G A GAGGATTTA T G T A T G CatnGeGATCTCGCAACCTGACTAATTCCGAAAATAATTTACATGAACGTAAC A A AAATCAGACTiTTCCC T A T T T T A C A A A A A A T G A C G T C G Ar C CCTAATCCTA A T T G C G T G A G G A G G A C C A To3 C A C A C CTAAGCCA T C G A A G A A C A G A T T G C'- T5 AGACATATAGGCTTTTCCGTGCAGCATAA A A A C T G G C T T G ATAATCG T C T T A A A G G G C' T A A T C A T C T G A T T T TAACTACA T C C A C A C TiA T A T C A C A G T T T A A C G T TAGCATCT C C C G CneT T C C G G T A T C A A C G G A C G A G CGAATTGA A AcCnGT C C T T C G C G C A T G A G G A A T T A T ACTCGCTeTGTG C T C C C C G A A G A G A T C A A G A T T C G CuGqGAAGCGTAT G C C A G C C G T A G T A C A A A T T A A ATATGTTGT A C C T T T T T T T T T A T G A G A AeTAGACCGATGAGTTTTTCTTCCC A A G A C A T A T G A T G T C AGATTAT A A T C T C A A C A G T A AS A C G G A T A T A A A TGATATTCAATTTGACTTTGGGATGAACTGTezislato)pTb1 8 1(543384OQNESD9I10121121P V P PeMC MV CMVma L _A0 L _A1 LC_A2NGRR01GRR01GRR01C A A T A G C A G A A A C A A G A A C T T T T A A T G G GGTAACTATACAATCAAATGAAGG A G T A T C T A A T T A A TG G A A T G C A A G C AACTAAAAAATCAG T A G C T A A TT T T G A G T A A T G A G A G A G CGAACTGTAATAAAAT TC G C T A G G T C T T G A TG CG A A AT T T C C G T A G C A G AG A T TAAACAATTTCAAA T T A A A G G G T C T T A T T CG G C C A T A T C AGATTTAGACAACT T T A A T A T A G TC T T G A G C T T G T G G G C AGTTGCCATACTCGAG T T TT C C T A A T A A A C TT T A TC AT A C T A A G T C A C A T A TG ATGTGAGAATAGGA A G T A A T C T A A A A G G A T A AA A G G T A T TGTAAATTGAATTT C A T C C G A G A A C CC G C A G T A C A C A G C TATAAAATCAATATCC T A A T AAGG C A A A T G A C T A C A A A G C T C TCTCCACAACGGTAGTAAATACCGA T C C A G G A T A T T A G G T T C A T AT T G A A GTGTTTTTCGCACT A G C G T A A T T T T T C GA T A G A G A T T T A CCTAATAGGTGTTGTT A A T T T A TC C G A A T T A T T A C T T T A A C TAAAAATTATATAC GA A T G A C A A T C G A A GA AC C G GT A C A T C A A A T T A AA G A ACTGGTCGACCAAT C T A T G A C A A T A A A G T CG A T C C G T A T TAATCAATAAAATTTG A T A C C G A C AG C A C T C C T T G T G C T A G TGAAATCACGATTA A T AA C T T G T A T C G A AG G A AC CT T T G A A A C A G T T A T GT TAAAATCCGATTCC A T T T T A A G T C T G A A T C A GG A C G C A C TACCGACAAAATACTA C C G T T A C C T G TG T A G T C T T A C T T C A G CGTATTTAACTT G A C T A CG C T G T A T T C T A C G G T A C A C G CAGATCCTATAA GT T G G T G A C T T T G T AT TT T TT T T T A A T T T G T T T AT C CTCGGAAATATGTT T A T T A A C G T T A A G T A T A AA G C A A C T C ATTCCATAAATC T G T A A C A T A T T A GG T G A C G T G C G T T C AAGTTTCTTCGGAA A G T T T A CA T T G A A A T A T A A A A T A A A A TTTTAATTTAAA T TA T A A C C T T A A A C C AG A GT A CT A A G C C T A T T G A T TT C TGTGTACGAGTG T T T C A C A A G T A T T C G T A A AG A A G G G A CAGTGCAATATC C T A A A T C A G G A T A TA T C A T G G T T T G C CAGAGAGTTCTC T T A A A T C T TA T G T T T T A C T T A T A T A T CCATTTTCTAATTA A G TC C G A G G G C A T T AT A T TTC A A A T C T C T A G T G A G AAGTACTATGGAT C T G G T T G A T A A T G A A A A T A T CA T A G T TTATCCACTT T T G A G T T G T A C A A A C C T TT A A A G C C T A GATTTTTAGATA A T T T C T G A A T A C AA T T G G T T T C A A T T C GAGGTATGAC T A G A T G T C TT C A T A G G C A A T T A T T G G T AAATTTTAGT T G T T TnT T T T C A A G T A C C A T C G A T G G T C GTTAAGTT G Aoit A A C T T C C T C A T A G A T T A A T A A T T A A TACTATTatGnACeCCG G A C A T A A T A T A G G A A C A A C A T A T A T AGAAGGATT A T A A A T A C T T G A C T T C T A A T A A AiGTAGAAGAACAAGCTAGCT T T T C A G T A G A G T T C T A G A A GATGTGACA A G T A G G A G C A G T A T T A Ar T A T C T G T T T G AATGAAAT A T A T T G T T T T G G A To C C A C A T T T C T T T G TATCAGTT T G A G T A T G A G A'3- ATGGATGAATCATTCGCACTTAAAGCGACATTTACAATTATCA T G C A A T T ATGTTTTCG A A G T A'5AniAGATCAAAACCTATTCCATTTCTCTTTGTATTTTTACAAAATCTGTGGGTGTTT T CGATTACAeCcTCnCTT T T A C A C C C A G A C T T T T A A C T A A T T T CGCTTCAACGA T C T T T A C T A A G T A G G T C A G G A AeCuTAqTATAACCATTTCCCTTACT T T G A C A G T T C A T T T A T T A ATACGTTCA T A T T T T C T C C T T A A T AeCATAATTTCAAGTAAGATGCACAGCATCTTTATTATTACGGCGTT T C A T A C A T T G A T GTGTCCGAAAATCTAT T G C C A A T T AACGATT T C G C G T AS T A T G A G T A A C C C A G A A A T G T AGATCTATCGTTGATAGezislato)p 282Tb(9381OQNESD2I23121PeMV P Vma LCG_MA3 LCG_A4NR R01 R R01T A G T C G C G T A T A T T G T A T T G A G C A G A GTTATCGCGTATCCTATAAACTCT T A A C T C G G G G A TT A A T A T T C T G T TAATTAAGAACCAG T A T T G CAAC T T T A A T T T T T A A T A A TTCCGGGGGTCAAGGAAAGTTAACTCC T T C G T T A T A T T T G A T G A GA A T C C TAATGGAGCATACAAT T T C A T G C G A A CT T T A T G A T A A T T AGAAATAGAAACAC T C G A TA G A T G T C T T TT G G G A CTA G T A A T C A T C G G C A GCACTATCTGTTATG T A A T C A A A C G C G A G G A AG A A G G A TATTAAGATATTAG T T T G C A A C G A TT T A T T C T G A T A A TAAGAAACCTGTCG C C A C TA A A T A A T T A CC A G G C ATA T A G A T C A G G G A G T ATGAAGATTACACTA A C T G T A T G A A T T T T G C GA A A C A G TAATCTTATTCACGAC G G T A G A T T T TA T A T G T A G G T A C A TTAAGTTCCTAGTG A C G GA A A A A A C T A T CG A C C TA AA T C A A T A C G C A A C CA TCACCCGTCTTCAA T A T A A G A A A G A G A A T AA G G G T G T AGTAACTATAAGAT G T A G C G A G C AT A A A C A T G T T T A T ATTATCATGTCGGG A T A CC T A G G G A A T C AC T G G GC GA G A T C A G C G G A C A TT TAAACTTGAGACTA A T G A A T T G T T G G T G G CT G T G C A T ATGAATTAACAAAATA A A G G A A G C GT T A G A A T C T A A A A T AAGCCATTCATG A T G G TT C A G T C T A T C A A A A A G T G A CTCCCAAAAAGT CG T C A T G A G A A T T CA TT TA A A C A T G T G A G A C TA CTCCTCAATG T G T G T A A A A G A T G T G T A C A CA T A G C TACGAGTTTA T C A T G C A C A C A C A A A GT T T A G C A G A AAGTTAAATAAT T T T C G G A G G A TT T C A A T C A A T G T G T AAACCTTGTT T G T A A G TT T A A T A A A T C A G C T G A T C TGTTTGTCTCGG T TA C A A A C G A T A C TG T ACG A T G T G C T A T C G G A CTTTCATATATAA A T C T A T C T A G T T C C T T A T C AG G A C T CGTTTCAGTC T T A T C T C T T A C G G C A TT T A G T T G A C ATCATTTAGT T A A A C T A C T C T TA A A G A A T A A A T A A ATAGAAAAGA T T C C C G A CG T A G A C T T A A T T A C T A G CACCGCGGACCG A A GATA A T A T A A T T T C A C T C A T T T T C AGACCAATTCATCACGAAA T A A C C C A A T T A A T T T C A G T A AG T A G GCTGTACATA G A A A A A A C A C A C A G C A TT G G G G A C G GAGGGTACAAGT A T C C T T T G G A T CT G A C G C T A T T T T A AACTTTTGTC G C A T C C T TT T T T G T A C G T C A A G T A T GCGAGTAATG T G C AnA G T C G A A G A T T A A A T A A C A G C GGCCATCG Coit A T T G T T T A A T T G T T T A A A A T C T A T ATCCGatCnGCeGTAGTA T T C A T A G A T G C A G C A A G C C C C T ATGACAACTTC G C G T T T T T A C T G A C A G C A GiGAACTGATTATAACCAGGTGTTA A T G T G T G C A G G A A G A AGACGTATT T A T T T G A C T C G T Cr T T A T G C A T T T C T CAACCAAT A G T C T C C T A Go A A A T G T G C A C T T T T T GTCTTGTT G C G C A A G'3- GAAAAAGATAATTGCTTTTATTTGTTCATCGGACCATTATGTGTACG T C T GGTCAATAG A'5C A A T A T T A T T C A T A A A G C T T C G C G GGACTniAeACcATACGAT A T A A T G A G T A T A A A T T T T G A A GnTGGTTGAAACATTACG T A A C G A T T A C A T G G A T A A AGACTAACTCT T A C G A T C T A T C C C A AeTuAAqAATTCTAACAGGTGAATAACCGATAATAC A C T C T A C C C C A AGCTAGTGC G T A G A G G G AeCACGGTTCTCCTACCTTGGGCTCCAGCTCGATTACACATGCATGTGCATTACTGATACGTCA C G T A A TTTTTAGCGAAGG G A ACGAT A CS T A C T T A G C T A C A A C T A A G G T C G C T CGAAAGGezislato)p31Tb(21114OQNE425SDI 121P PeMV C V _MCmL L _aGA50 GA6NR R 1 R R01A T A A G T T G C A A A T T C A C A G A T A C G A G T T T ACCCTACAAACAAAGAAGAT A G A T T C T A A C T G A C G G CT T A G T G C A G CGTAGTCCATAT A G G A T G T A A T G GC C C A C A A T T T A G C T CACCATCGTTTC A T A C C A TT T T T T A C A T C T A A A A A C C G GTACAATAATAG G TT T T T G A A G G C A A AC G AT TT T C C A G T C A T A C T A TA CTTACTCTGTTT T G G A A T T A C C A A A A G A A T C CT G A A C T GTTCTATAGTTGGA A C T T T T G T A T C A T TT T C A T A T A A A T A ATTCAGGCTCTG T T A A T G A C AC T A T A C C A A G C T G T T G T AACTTATCCTCT G A A CTAC A T A G A G A A T A G T T T T A A A C T GATGTAAAGCGGTTGATAAATGA A G C C G G A A G A G A T C A T T G C T AT T C T A TTATTGTATCTT G A T T C T A C C G G T G A T GC A A G A A A A T A GAAATTTATGTC A A T A T T T A T C AA G G T T C A G T A A A A T T ATCCGTTTTCGG T T G A A CG T A A T G A A C A T A T T T T T A T C AGTATTTCCAACTGT A T G T T T G T A C C A T TGG A A AG T A T G C C A T G A A GA G A GACGTTCTAATG C T T A A C C C T G C A G T G A A AC T G T A A A T AATTCTAAACTT A A C A G C G T T A T G CA T A T A T A C T A A G A TAACAATTATCGAA G A T G C A TA A A A T A G A G T A T A A T T T A T CCTTAAGTTGGA A GA A C C G T C A T T A C CT G AA CT T T T C G G A T A T T C A AG GGAGTTAAAAAA T G A A A G C T C A A T C A C A T T C AT A A T T A CCGACTAAGCTCAT A T T T T C G A A G T C G AT C A T C T C A A T A A GAACATCACTGA A T T A A C T G TC C C A A A C T A C T T T T G T T AACCACTCTTGC C G A AGGA C C T T T A T A T T A A T G A C T C T T TCTCGCCGTCGATTTTACTAATA G T C T A A A T T A A A A G T G C A C C GC T A A C AAAAATTAATCT A A G G G C A A A G T T C C G GG C A C A T C A A C GACATATTATAG T C C A A A T C A G TA A A A T T A A T A A A A C T TTTTGTGTCACC A T C A A CT T G C G T T G T C G A A A T A C T A G GAAGTGTTAAGAGGT T T A A T T T A C A A A A AGT A C CG A C T T T G T A A T G GA T T ATCGTAATACAT A A C C T G A T C C T A T A T G C CT G A C C A T C ATTAACCATAAT G A A A T T T A T G A T TT A T A T T C A A T C T A AGAATCTACCAAAG T A A T T C CT G T A G A A A T A G A C T C A T A A TGATATATACCA A GT A C A A T T A G C G A AC T AG TA T G C C C T A C T C G A C AA GTCCTAAATGAT A A T A A T T T A A C C A G G T C A G CC T A T A T CATAGCTCCAAAAT C A C T C A C A A T A C A CT G T C T T T A A A T A GTTTCAAGACAC A G C A A C C C AT T C T T G G C A C A A T C A T C CATTGTTATAAT T G C Cn G C A A T T T T A G C A A A C A T C C G T T ACAGGGTCTGCoi At GGTGTGTT A T T A A A A A T A T T T C G A T C C G C G TtA T A CTATATTC A C A G C T T A G A T T T A C A T C A AanAeCT T A A T TACGGTGAAT T T T A T G T G A T A A G A C GiCATGATACTGATTATTAATTTTGCGATTACGGATTATCCTTTAACA T A C A G C G A A A G AAAACAGCGGTATCCAGTA C T T C C T ATAAAAAAC G C C Cr T G G A G C T T C T C A G T T T C T T A C T TCATGAGCGCo3 A T T G A G A T C C T A T CG'- CCTT T T A C T C C T G G A C AATTGTAAG A A A T A A G G A T A C A A G C A T G G G G T'5GTTCCGCTTTTGAAAAAGA A A G T G G T C C A T A C A A T C A A CTTGAAAGA A A A A T T A C A C T A C T G G TnieAcTGCTCTGCTAGGTAGTTACTAAGATGGGTG T A A C T A T T A G T C T TCATATTTATC T A A A G G G G C CnGeGACTCAGATAGGATATTATAAAGTCCACCTTTCCTTAGTGATAT A T T A G G GAACATTAT G T T TuTqAA T T C A A A A A A T T T C T A A A C A C A TGAGAGGT TeAA A C G A A A A T A C T C G A A C C C A A A A T C TGGTAATATTT T A T A C A G T A T T T C A G A A G A T A T G A CS C T TCTGATGCTTAAAGTTAAATAATATAAGTCTTTGTAATCTTTAAGGATGGGATezislato)p75Tb(02OQNE6SDI21PeMV LCm_aGA7NR R01A T A C G A G A C T C G C A T T T G C C G A A A C C A T T CCCACCTTCCGTTCCCGCCGAGTA G C C C G T G A A C C G A G CG G A G A G C C G C T TTCACAGGGCTAGC G T A C G G A A CG G A T C G C C T A C C T G G T C TTCGTTCGAACATG A A TA T T C C G G C C G C C CG A A TC CG G G C G A C C G G A A G T TG GGAGAGGTGGAGTG A C T G T G T A T C G A G T A C G T CG A C C T G C GACAGCATCGAGGT A A C G G A T T T T A G GA C T A G G C C A T C T C GAACACGCCCCGCT A G A C G T TG C C G G G G G G C T T T G T G T T C TGTTAGAAGGTATA AG C C G G G C G G T C C C T GG CA A C AA C G C C C A A A A T A AG G A AACACCTACGGACT C A G A G G T A G C C C C T A A TG T G G C G C G T GCGTTGGAGCAACA C A A A C C A A T A TT G T C A T A A C A C G A G G GAAACTCCACAGAG A A A T CCGC G C G A A A C T T T C T A T G T A C C TAGGGAAGTATGTAAGGACGTCCGC T C A C C C C G A T A T T T C T A C G T CG T A G C GCCAGCTAGCCTCC G G A C A C C C C G A T A T AG C C T A T C G T A T TGAGGGAACGTGAG C G G A A T A G TT C C G A T T A G T T T C G C A A CGGCTGTACCGAAG A A AC C A G T T G C G A A G CT C G TG GA A G G C G G G C T A T G A CG AGGGTGGCAATACG G C A T A G A C A T T A A C A A T A GA A A C C G T CGAGATCCCCTCCG G A C C C C A G A G T T GA A C G A G A C G C C C A GGGACCAAACCCCG A T A T T T GG C T A C G A T G C C C C C T C G A T GCGACACAAAAAGT TA C T A C G A C G C G G C C TT GG C C CT A C T A G T G A C G G AT C C TCATCACAGAGACA G C C G G G T C C G T C G T G T AG C C C C T C G T CCCGGCGGGGGC T C A C T T G G A A A A GG G C A C T G T C A T T A C GAAGACTCCCAC C A G A C C C TA T C A G G A A G C C C A T G A G A A TTTGGGGTGAAA A T TC C A A A T A C G C T G AT C G TAT T A A C C C C A A G C A C G ACCCCGGTACTAG C A A C A C C A A G G C C G T C T T T A T TC T G A G GACTCGGCTACG T T A C A T C C T G C A C C A A CT C G G G T T G G G CGGTCACAGGGC C C G T A G C T G G C GT C T T A G C G A G A T A G A AAATTTGACTAG G G G A A G AA C G C C G C C G A G A A A C A A C G C CACAGGACCTCC A AC T G C G T G C T G T G A AA A CC CG A G C T C A A T C T T A A AC CACCCGACCCCC G G G T C A G G G C T C T A T C T G G A GA T A G G A GCAAGGGGGACT C G A T C C A T G C G G T A T AA G G G G A T A G G G GCCCTGAGATCA C C C G A A G A G T CC A T C T A G C A T T G G C G A ATCTCCCGTTAC T A G G A AC C G T G T A C C T T A T C T A C C T G T ATATAGTGGACT CA T G T T T T C C G C C C C GC CA C GA A C T T A A G A G T T T GA T ATCGAGACGTGC G G C C A T G G C C C T A G A A A T T Gni G G C C C A T TGTGGGGGTC C A T A C C C C T T A G G A T Tot G G C C C A C C C T G CTTCTAGAGC A G G T C G A A A A C CtA A G G A C C G C C A C C C A AACAGGAG A G G C C C A A TanG G G T A A G G C T C G A C C G C G TGTCCGAACT A T T C TeT G G A A A G G T C G A A C G A A C G G G C GTAGTTGCCA CiC T A A A G T A T G T G G A A A G C C A A C G A G T TACTTrGTGACTCTT G C G C T T T A C A G A C A C G T A A G G A C To C G C CAAAGCCGTA T G C C A G G C A C C A T G A G A T A G'3- GTACGGACTACACCGCGGCACGTACGCC C A A A G G C C C T A T C C T TGTGTCGTG C A G C G A C T C T A T C'5CGACGTCAGGATGGGTTAGTGAAGTATCGGTACCGCTTATAC G T G C C C T T CGGAGAACGAA G G G T AnieAcTC C G G T T C T A C T C C A T G C T G C A GTCACTTGCC CnAG A T T T C A C G C C T T C C A C T T T A G T C T CGTCGeTGuGAGqGCCGGATCGT T C G G C A C C G G C C G G G T G C T G G T GATAATGGGTA A C C C A A A A G A A C T T C T T G GeACCTTTCTAGAACTTCTGGGCTCCAGCGAGTCTGGCAATC G C G C G G A C T G A T A G TACCTATGTATGCAGC T T A A T T C T G T CAACCCCGA G C C G A A T CS T T C T C G G T G A C T T A T C G C G ATAGGACCCTCTACAGAACezislato)p30 2Tb(5119OQNESD7I28121PeMV P Vma LCG_MA8 LCG_A9NR R01 R R01A T T G G G C A G T C G C G G T C G A A A T T T C C G GGTTCAAGGACGACATACTTAACCCA T G A A A C G T A T T GA G T A A C T A A C A G TGAGATATCAACAC A A T T A GTGT C A A C G G G G A T C C T A G A TATACTATCTTCCTCTCTTTTACATCA G T G A C C A A G A G T C T A T G C CA C G C C CGAAAGAAGTTGGGAG C G T A C C A T T C T TC G T G A C T A C A A A CAGTCACAACTGTT T T T T C TA G T G G C A C T C C T T T A T A A T CCGTATTTATCTCAG T T G G T G A C T T C C C TTG T C TC A A A T A A T A T A TA T G CGAATTCGTCCGTT T G C G C T T A T G A C T T G TG A A G C C T A T GGATCCTGTATG T T T A G A T A T C AT C G G G G A A T A C G G T TGTCCCGTTATTTA A A G G GC A G G A T C A C T C T T T T T A A T A CAACGCTTTAAAG T T C C T C A G T C T C T TAT C G T AC G A C A A T G C T C AA A T C GCCTTCGAATAAGT T C T C T A C T G A T T C T TC G C G G G C T T A GACCATTATTCTCC G A T T C T T G TC T T A A A A A G A G A C A G C TCTGAAACCGAA T A T TC C A G T C C T T T AA A C G TGT T G T C C T A A T A G A A G CTTGCCAGCGACA A T C A T C T T G G T A A G A G C C T TC A T G T GAGTTTTCTCGCGT G T C T A C A T T G T A C AT C C A G G A T A G G TGAAATTCTTTC T G G A G T T C TT G T C T A G C A T A T G C A A TAATAGATCATGGC C T CT T A G A A A G T A T AT C C GA CG T A G A A A T T T T G C A GC TCTTTACGTGGTTA G A T C T T T T G T T C T T T G A TG G T C G C G AATAGAACTAGG C G C A A A T A T A T G TT A T G A G A T A T G A AAAGAGACCCTCAC A C A T G T GC C C G A G C C G A A C G C C C T G TAGTGTTACTCG T CC T A G T A G G T A C C TA C AA T GC T T A G T A G C T A C T CA C TACGAAGGTTTC T A G T C A C C A T T T A A T G G CC A C T C T C GCCAATAAGTGTCC C A C A A G A G T T G AT C A A T G G G T T T A A T CACAGAGAATTA G A A T G T TT G C A C A T T T G A A C T A C T A A TAAAGAGTAACT C CT G A A T C T G C T G A GG G GAT C C C C A T A G A A T C G AAGGGGGTTCTCT A C A T T G T C G C C A C G T T C T G A GT T T A G GCGTCAATCC A G T T C T G G A G A T C T T C TT G C C T G A A T AGAGTACTGCCA T A T C A A T A C A C AT C T G T A G C G T C C T T ACCAACCATG A G G A A C T CT G G A T C T T A G A T G T A A G C AACGAGTAAGCA A G GA G G C A T A G A T C TT C T GAA T C C C A T A T T A A A G T ACTGAGTGCAAAA A G T G A A T G C T C G C A T G A G T G CC C A T T GATGGTGTAG T A T T A C G T A T C T G G G T AT G C T T G T T A GACCGATTTCAC T C A T T G A G T T C Tni C G C C C T G C A A A T A C CCCGGTAC T T G G T A G T Cot T A A C G C A A G T C T C T T A T CAACATATGA T G T T AtT G A A T A T A T C T T G T C C C C A A T GAAAAT A C GanA T G A T C A T C A C A G T G G G G T G A T A GATCACTGGeAiTCGCTGCC A G C C T T T T G T G G G A C T C T G G A C T TCATTCGTG T A C G A T C T A A G A T C A G T A G T Tr A A C A T ATGTGCTC T C C T T A C T T T T G G T A C G Go C C G C A A A G ACGTGGTGGT C A C A T C T T A A T G A T'3- TCCGAGACCCGGAGTCAGGTTTGGGTCGTTATGTA C C G T G C G A T G GAGTGGAAT T A A T T G A A'5CCTCCCTGGAACGTGAGAACAAGATCTTCTGGCGACCCAAACAACAG T C T T AAAATTGAGTG AnieGcCA C A G G G C A T C C G T C G T A A T A T A A C GGTCTnCGTGACGACA T G A T G T A A A T A T T A T G A G C T T CeTuTTqTCCGGTGAGTCTGAGCA C A T A T G C C T C T T A C G T G T TTGTAGGCTAA C T G C A G C A G C T T T T CeCCATTTATAAGAATCAAAGAACCCTACGAACGATTTCTACGATAA A A A A A A C C T G T CATTGGCATGTGTTAT T A C G T T T GCTAAGA C T A T T GS C A T A T T A A A G C T A C T C T C T A GCCGACCAGGATTTTezislato)p 521Tb(7521OQNESD9 0I2131P MV PeVma LCG_MA0 LCG_A1NR R11 R R11G T T C T C G G C C T C A C C G C G A A A C T A G A C G GGAGACAGACAGGGTGGCCCTTACAT G G G A C G G G G G G A CT A A G C A A G T A C C CGTACTCACCTACGAA G T A A C CCGA A T C G A G C G G A T C A T C C T GTTTTACCCAGGAAAGCCCCCTCTATG G C T G A C T G G G A T A T C C C A C AG T C C G CAGCGTACGAGCCACC A G G C A C G G C G G C AC A T C A C A G C T T G GGTGTATACACCCAGT A A A G C CTCC G G A G A A G T G G G C C A C A C TACGACACCACTAGGGCGACGTCTAAC G G T T G G C C G G G G G G C G G C A TA A C C C CCTTACTATCCGAGAG A G A G T T C G T A T T AA C C T G C T A C C C C GGGAGGTATTCATGTA T A C T G CCTG C C A G C A G T G C T G G C A C C ACAGACGACCGTCAACGAACTTCTACA C A C T G G T G G C G A C G A C C A C CC C C G C CCGAACCGGCGGATCA T G G G C G G C A G C A CG T C T C C G C C G T C CTCTGCATCGTTCC C T G C A G C GC T G A G G G C G A A G G T A G G C GAGACAAGAAGGGG T GG A G A G A G A A C G G GG C TG CT G T T T G T A A C G A G T CA CTCAAACAAGTCCC A T C T C C G C C G A A C G T G T C CC C C A T C A GCCGGCTCCCCGTA T C G T A C A G A C T G GG G G A T C C G G A C T C TGAACGGGACTCGA C A C C G G AG G A G C G T A T C C G A T G C T C C TCAAACAACCCA T CA A G T A G A C C C A G T AC G CG C GA C G G G G C A C G A G G AC C GGGCCAACCCGTCC C A A C C C A G A T A C A A G G C GC T A G A C C C G CCACCGTTCATA C G G G C A T C A A A G AG C C T A C G C A C G G T C TGGCGCGTAC A T C G G G C T AG T G C A T G T C C G C A G C T A G GCGCCGTGTCAA T T G CAGT A T G C G C C G A G A A G G C A A G C A T CCACCCCGATTGCGGTCCGAC G T G T C T A A T A A C A T C A G A C C C C GG T C A GCAACTCAGC G T G C T G T G G A C G A A A A A T AT T G G G A T C TCCGTAAGGCCA A A G A G G T C T T A A G GT T A G T A C C C C G C T CTCCGAATGCCG T G T C G T T G GT A C A A C C T G T G A G C T G T G AACAATGCGGTT C T T AC C C G C C T A A A A G A A A G T A C G A T T TGATGCCTCCA A G G G C G C C T G T G C C TTC T A GG G C C C A A C A T A T GG T A TGTCTGATCGAT G G A C C G G A C C A C C G A C G A GA C A C T C C A CCAGTGACCTGG A A C A C G G A G C G T C AC G G G A C C C A C C G T AAGGTCCGAA C A A C C T G A C GT T G A C G C A G T T A T G A A A CCAGTCACCAAC A A C T TC T T G C T T G G T C C T A C G A C G C C T GCCTGCCAACACT A G A T C C A C A C A A C G GCA T C AG G G C A A T T T G C G AA C G GGATCGACCT G G A C G G G G A G C A A A G A A A A CT T C A C C C GCCGTACTACCA G G G T T C G C C A G C G G Tni G A A G A T A A C C G C ACGACGTTCT A C A T A T G C G A Aot T C A T G A T G C G T G C G T G GTAGGGTAAC T A A T G A GtC C C A G A A T T T A T A A G G A A G C AGAACT C C G T AanC G A A G T T A C G C C C G A T G A A T A C TAGAACCGGC CeGiTA C T A T C G T A C T T A A A T C C A A A C A C G TACGGAGAAACGA T T A G C T C C C A C C C G C G C C G G A G T Gr C C C GACGACCC G G A G C A A A G C G C A A C A G C G C Co T G C T C C CTCATGGTAT G C T A G T G T C C A C A C G A G'3- CGGGGAAACATCGTTCTCGAACGCGTTCACAACA T C T C A A C A C C G A GGGAGGGAG C C C A C G T G A A'5GTACGTGTCTCTCAATCTACTCTCGGCCGGACTCAGCGGGAATTA A A T G G G AACAACCAGTA T C CnieAcCT T C C C C C C A T G A C T A T A C A T C T C GCCGTCCCGnCGATCG C C G C T C A G C C C A G C G A A A T A T C C C GeGuTAqGAGTTCCGCTAAA T A C C C T C G G G A G G C C A A G C C T AACCACGGGAC T G T G A G A G T T A A A C G C C GeGAGTCACTTCTCGCTCCCCCTCATCCCGCGTAGCTAGTTATCG A A G G G G C A C A A G G GCCCTTTCACTATCCT A A A G A G C A G GAAGCAC C A C A G C T TS T C A G C T G C T C C C C C G C C C T CACACCGATGTTGATAATTezislato)p 254Tb(3903OQNESD1I32131PeMV P Vma LCG_MA2 LCG_A3NR R11 R R11T C A G T C G T C A C A G A C T C G C C G G C G C T C C GCGTGGGGGACGAATAAACT A T G C A G G C C T G C G T C TG A T G G A T C A CCTGAGTCCGAG A A C T C T C G T C CA C C T T A T G G C C G C G CTACTCCCCTCGAC G A C A GG C G C T G T G A T C G A G C A G C A A AGGACCGCGCGAG T G G C G C A G A A G G A CGG C G A GC G T G A G A G G G G GC A T G TACCGCTACGAG T T C C T C T T T A A G A G G AT C T A C T G C T CTCAACGAGACATG C G C A A G C C A GC G A G C G G C C G C A A G C TTCAAACGGGGG A C C C GA T C T C C G A G G T T A G C A T C C T AAGCTCCCGTGGT T T G G C G G G C C G C A GGC A G GT C C C G A G C G A A AG C G TGGTTGGAGGATAA G G A T C A G C G G T T A C G GA C T A A A C T T CGTGGACTCCCT T T T G G C T C A A GC A T C A A G C T C G A A C CCCCCCGGAGTGGC C G A T GC C C C G G G T C T T G A C T G G T C A ATCCAGTACGGGC A T A G G G A C T G T T C AAT C A G GA T C C T A C A G G A TA T C G GGGGAATCATCT G A T C G C T C G A T A G G C CA A C A T A C T G ACGGTATCGACT C C G G C C G T G C CT G T G G C T G A A A G A A GCCTTTAACG A G G A T C C TG A C T T T C C C G C T G A G A T G GGAGAACGAGCC C C CTCG A G A G A C G A T C T G A C C T G A C C C TTGGAAGTTCTCGAGACCG A A A C C G A A A A C G G G C G C G T G G CA G G G CGACGGTCTA C G T A A G C G G G A C G G C T G GC A A A G A G G CGGCTGATACCG G T G A G G C G A G C T TG G A C G C G A G A C C T GGGGTGGACT A T C G C G A C TC T A G C C T G A C T G T G A C A CCGCGATGTG G A C A TA G A G A C C A G C T G T A C C C T G A C CCGGACCAGA AC A A G C G A C T G C T T AA CG C AA G A C G C G C C C G G G AA A AACCATCGGG C G A T C G C G T C A G A G T T C A G TT T A C C G ATTAAGTCCCAT G C A T T G G C A T G C G A TG T A C C G C T C C T AAAAACCCCA G G A G A C G C G A CG G A C A A C C C A C A T G C GCAGTAAGTACG C T A A G GT G A A A G G C C C G C T A A G C C G G GTAGTGGAAG A TA A A G A T G C G C G C AA A TCC C A T C G A G C C A C C C AGGGAAGAGGT G C G C G C A C A G C A T G A T C C C A C TG C A A GCCATCCGGTAG C C C G A C C G G G G C T G G T CA G A C A A A C T CTCGAAATTT C G G G G G A C T G T G TC G G C C G T G C C T T T CCACTAGGTACA G G G A T G T AC A A A A T T T G A C A A C A A T C AGGTCTCGAG A A C CGAG C G G G T G G C C A A A A A G G C A G G CGAGTCCCGCGTGGTCTGG T A G G A G T T G C T A G T A G G C C C G A AT C C ATGGATAACT G G A T A G A A G C A A G C C G G C GA C G G A C A TGGGTTCAAA C G A C A G G G G A A G A A AnA C C T T C G C G G C GTCCCGACTT C T G G T G C T C C Coit AAAACTGACAGGAGCTTCGAGAGTTCGTCCACCAAGGCGGG T G T G G T T GGTACGTCC C G C C GatnAeCGTCACCTCATACGTACCGACAACGCCATCACCACGTTCGGCCTCCGAGAGT T GACTCTACiATTCA G T C T A C G C A G A T C T T G A A C G C G C T Tr A GAGAGAGG G T G A C A T T G C C G A C C C T A G G C Go3 A C T A GGGGATGG T C T G C T G C G A T C C C C G A G A'- A T G G T A G GAAGTGGATG T G A C T G C A T C C T C T A5 A A A T G C T T C C A GTATCA C T A A T C T C G G G T A' AiTAAGAGGGTGACCCTCTAAGTTGGCCTCCCTCCGCTCCA G C G G G G G A ACGGTCTCA A T T A C TneC A A A G G G C C G C A G C T T A A G C CCGGGGAGTC C AcAnTG C A A T G A C G C C G G C C C C T G T G G A GCGGACGeCGuTAAAG A G A A C T C T T T C C A A A G C A T C A G C GqCCGCGGTTCAGCGG A A A T T T C C G A C A G T G C C T A C GTGTCACCCGG C C G C T G C A T A G T A C C C TeTAGAGGGACGCCCGAAACGGTAACAGGGA G A T T G G G A A C C A T CGGTGGACA A A G G C C C T C C GS C G T G A C A A G A G T A C C CCTGACCCTGTCGCCGAAGCCGGGGezislato)pTb(OQNESDIemaNC A A A C A G C T T G G A A G C A G A A A A T C A T C A GATTCCCTACGCTTCTTTTTAGACTA G C C C T G G A C C A G TG A G T C G C C G G G A TACTCTCGGTTTTGGT A C T T A GGTC T T A G G G G T G G A A T A A T C ATCTACTCGACCTGTAGTGGGTGAACC C G T T A T A C C A G A C C T G A T C TG A G G C TCGGTAAACCGAAGTT G C C G T A C A G C A T CA G G A C G T C C T G G CTTGTTCCTAGGTGGA C A C C A AGTT A G G A C C G T T G C A T G T G G GTTACGGTACATCCCCCGCAAGATAAC A T T T G T C G G C A T T G G G C G G AA A G G A AACAAGTAACAACTAT A A G C C C A G A G G A GG G G T A T C A G C T T GCTCCTCTCGGACCGC T G T A A GTGG G G G A C T A C T C A C G C C A G AATCAATCGCTGTACTACTCAGGACGTCC G G A T A C G G T A G T C C A C T G AC C C T C G TGAGATAATCTATAAT C T C G T C A C C G T CG A G C A G A A C A C T G ATGTCTGGGTACGT G T G C G C GA A T C C T A T T G G A G C T T T A C GCCAACTGACATTT AC G G A T C T T G G A G T CA GA T AC A T G T T A G T G C T T AC G GGCCAGGCTGGCAA A A T A G C G C T C G T C A T G C GA T A G A G T G CACCCAATTAGACT A A T G G A G G C C C GG C G G A C G T A C A C T T GTTGGAATAACAAC T T A A C GG G A A G T G G A A A G T T C A T C G G GAATTCTACACG GG A C G C C G A G C A T T T AG TA C T TA A T A T G C A A T T A AC T G ATGGACTCGAATCG T T T C T C C G C G C C G G T G TC G A A G T C C A AGATCTTACGGTTT T T A A C A G C C G TC G A C A G T G G T A G T T G CTACTGGACCCT T G G C T AG A C G A G C T G T G T T A A A A G A C ACGTCTAGGACGTTG C A A C A C C C T T C T A A GAA G A C AG T G G A T G G T G G AC A T C AGGGACATTGCTCG T G C G A A A A T G T A G T T CC G G A G G C C G A ATCTTGACCTCAAT C C G A T G G C G GT T G A G T G T T C G G T T A C CCAGAACAGATATT G G G AT G G C G G G C G G T GG T T G TAT C T A C C T T G A C A C C A CCTGGTAATGGCCGT A T T G T A T G C T T A A A T C T A G CC A A G C G CTTGACCAAAGT G C T C G T A C G A A G C G CT T A G C A C T A G T ATTAGAGTCCTTCA T G G C T T C A TT C G G G C G G G G A A T G T C T TAGTAACTGCGGAG G G TT A A A T G G A C T G G TA G T GG CA G T T C G C G A A A G T C TA ACAAGCTGGTA C C C T G T T A T T T T C C C G A A T A CT G A A C G CGATCTCTGGGT T G A C C C G G G A A G C C A TC T G G G A T C C A T TGGTTAGAGCAG A T G G G C C T T G TA T G G G G T G A G C A A A A A TGGTGGGAGACA G T G C T TT G A T A T C A G A C A C G T G C T T T A GAGGGAGGGG G CG A G T G G G G G G C T C TA G TnGG G A T G C T G A A G G C G Aoit AGATTGGCTCATCA T G T T T T A G A A A T G A A G A C T G A T GGGTTTGAC C A T G T G T A A A C A G G T A T G G TatnCeGATCACTTGAAACGCGCAAACAATCTT G C A G G A T T A G G C G G G ATAGAGCGGAT G A C T G A A T A A T CiTCTCCGTCACAGATGACTATTCTGGGGTTCCTCAAGTTTTAGTG G T A G C C G CGTCATCCA G A C A Tr C C G G G A T C G A T T G C T C T T G A G T TATGTGGC A Ao3 A C C G G G C G C G A T AG G C'C G G C T T A T G G A A G G G A- C5 AGTTTA A A G A A G G T C G A G G G C T T G A C A G A T C' A C TGACAGATTT G A G G G G A A G G T G C T C G C T G A AiG C C C C T ACCTAGTT T G A T G A A C A A A T G G G G G CneCcTT A A G C T G C TGTTTAGATT C G C C G A C A G G A A T GnACGGTCGGGGGCTAGTATTTAGTAGCCATCCATATCTAT G C C A T A C C A TATAAAATGAA C G A T A GeTuTCTGTGAAGTGACACGACCAGTTATAGGCAGCTAGAGTTTTCACGGCGTGAG G G TCGGTTAACTqTeGGAAGAAT C T C A T G T G G G C T T T T G G T C C C G G C TTTTCGGAG G C T T T T T A A T G T G A G C T C A A A GS A A G T A CAGGGCCCTTCTTGAAAAGATAGTATTGGCTACGGCGGGCGCTCGTGezislato)p 64275Tb(642172OQNE334 5SDI 13131P V P PeM MV Vma LC_CNGRA4 L _MCR11GRA5 L _R11GRA6R11G G T C C T G T G G C A T A C A G C T T C C C A C T G C A C T CGTCCAGGGAGCAAGGCACG A G T C G A C T T C G G T A C A A G AC A A G G C G T T CGCGTATAAAGG G G T C T T G T A T G C T GC T A G G G A T C A A G A A GAAAGTCACTCT C G C G C G G A TC T T T A A G C G G G T A A A C G G C TCTCAACGGTCC G A C CGTC T C T G T C C G T T G A A C G A T A C C C T ATTTCCATCCGGACGGCGTCT T G G T A A G G C A G G G T C C C C G T C G G CT C G C TTTTTGTCCGCC T T G A C T G T A A C A G T A T T A AG T T G G T T A A CGACCGATACTG A A C T A T C T A C C G C CG C T A G T T G C A G A A C GTTTTCCCCCAC T T G A C T T A CA G C C T T T G C C C A G C G G T G T ACCCCGTTAGTA G C C TCCG G G C T T A G G G A T T T T C T C T C G C G TGGTTGAAGTAAACCGGGTAT T C A T G G C G A T C G C A C A C C T A A T A AG C A G GTTTACCGTCTG T T T A C C C G A A A C G A A C A C AG C C G G T A G A CTGGTAGCCAGT C G T T C A C A T C G C C GT T G T G T T T C C G G C C ACCGTTGCCCGC G G G G C T G T GA T G A T G C T G A G A A C G A G G T TCCACCCTAGAC C G T GGTC A C G T G G G A T G G A A G A T G C G C C C GGGTGTATCGGCCCGACCAAT A T A C G G T C T T C C C T A T A C G T T G C TG C T C TGACCACCACCT A C C C A G G G T C C C T A G A G G TG T C C T C C C T CCGTACGCCATC T G T A C C C C C T C T A AG G C G A A G A T T A C T A GTAGGGACCGGC T C G T C A T A AT G G G G C T C A G G T T C T C A T G TTTTTCCAGCGC A A G GCAA T A A G A T G G T C A C C C G G G T G C C T TCTTACGGAGACACCCGTGAG C T G G G T T C G C A A A C C T A G G C G G C CG A T G AGTCATGGTGAG T C C C G T T G G C C C T G C G T A TT G C G A C C G C CACAGTATTCAG G A T T G A G C T C A G C AC G T G A T C G G G G A A C GCAGGGACCAGT C C T T C C T C AC A A T G C G A T A A T G T G C G G G AGTAGTACGGAG A G A GCTT G C A C C C G G C T A T G A G T G A A A C A TAACGAGGAGACAGACAAGGA G A A A A A G T G C T C G G T T G G A T A A G AA G G C ACCCAGAAATCC C C T T A G A T A C C A T C C C C G GG G T T T C C A C AGTGAATCATGG G A T C T C C G A G A A G GG T C C T G G A G T C C T T GACACACCCCAT G C T C G T A T GA C T C C T G T C C G G C C A C G G T CTCGCCCAGGAA A T C ACGC G A C G A G T T G A C C A C G G C C A T T G TCCCGCTGGACGTGTGGGAGT C A C A A C T C A C C C C C A C C T C C G G T CT T G G TCTATCGCGCAC C C C A G G C C C A A T C T C T C C GT C A G G T C T G CCAGAATACACG G T G T C T C G G A T C T AA T C T G C A G C C A C A C CGAAAATACGTT G C T T G C C C GA C C A A T T A T A G G C C G C C C A TCTGTGTCGGAA G A G GAGC A G C G C G C G T A G A T A C C G C T C A T CGCTGGATTGGTTCGAGGCAT C G C A A C T C G G G T T T C T T C A C A G T TnT T C T CGGCGTCGTG T T G C G A A G G T G C C C C G C A A Goit TTTTGTAGAAGAAGGGCACGTAGATGGAGC T G G T G C T C G C A G C A G AAACTCGAG C T C T C G T A A C G G AatnCeCCGACTAGTACCCACGTAACCCTTCCCCTCTGGGGAGCCGCAC A T C C G T G T CGTCCTGCTGC T A A A GiGTTTCTGACCGGCTCGGTATGAGTTAC G A C C C G G C G TCAAAGGCGAAGTrC G G G C G T G C T C C A T T G AoT3 CCATGATT G C T A T T T G A T G G C A A T T G G A G A C A G'- C C G TTTAGCGTGG T A C G C C G A G G G C C G T C A C C C G5 C T A C C G A TTATTTCT G C A G T T A T G C T T C A A G G T' AiCCACCTCTTCTCTCTCTAATCGCAAGACAAAAG A C C A T C G C C T T C A AGAGCGACCCT A C T G C A C A A GneC C T C G G C T C C A C G G A A G G TTTCCCTGGT A A A C C TcCnCAGCGTTAAAGCGGCCAACCCCTTATCACGGAGGGCTACACTCACCTCCGGATCATC G CCGAATGTeCuGTqACTCGGATG A T T G G A C C C C G T A G G A A C C C A T G C TGCCCTCCCTT G T G G T T T C T G G C G G A A G C A T CeAGCATTGTTCTTCCGCACGTTCCTACGT A T C A C G G A T G G C T T G C ATGTCTCTG C G T G A T G G T A A T G CS T C A G A T T G C C A C C T GTCAGGGGAGTACCCACGTAAAGCTACTAGGezislato)pTb(OQNESDIemaNG A T A T T A A T A C C C C C C G A A A C C A A G C G G C TATCTAACATCTGCCTCGAGTT C C C T A T G C T T C G A C A GA T C A C A G T C A GCATAGTAGCGGTC G C C C G G A T T AC C T C G C A C G G C C C C A T CGTATCCCCTCAGT A G A AT A T A A T G G A A G TA G T C GCA A C C T G T G T T A G G A T ATGTTCATACGGACT C G C C G C T G C G C A G C C G G A T TC G C T G A ACAACGGACGTGTC T C G A T A T T A A G G A AC T T A A A A C C C T C GGTCTCTACGCGGA T T G C A A C AC C G C G C G G T G C C T C G T G G ACCCGTCGAGTC C G CG C A A A G G T C G A T CG C T AT CG T C C T T C A G G A T A A GG ACTGTGAGTAGGAG A C G T A T C C G A A A A G C A A A AG G C T C T T CACGTCCACACGGA T A T A T G T A A G G T AT G C G G C G A C G C A T GGTGGAGAAACTGA C C G T G C AA A A A G C T G G A G G C A T T T A C TGGTTACACCCAAC CG C T A C G A G T T A T A A AG GG T CA G C C T T A C T G A C A AA C TACCTGGGCGAA A A C T C C G A T T C A C G C T G G T AG G T C C A G TCCTATCCTA G C G G C A T A C A C A G G C AG A C T G G T G G A G CCAGATTTCACG C T C C T G C A G T TA C G C G G C G G C G C C C A C GAGAGGGAGCGA G G C A T GG T T T A G C G G G A A G C C C A G A A T ACGGGATGGCGT AA T T A G A G T G T G C G C CC GG C TG C A G G C G C T A A G G GG T ACACACATTTCC G T C A T G A G A A A G T G C A A T A GT C C A T C T TCTATGACGGAA A C T C A C G C G G A A C C GC C A T T T G T C A G T CACGTGTCGATG C G C G T A C C G TT T T T T A C C C T A C A C C C G TAACCGTATTCG A T A G TC G T T C A G T C T G G G A G A T T G A G C CGTCCCGAGACCC T C T T T T C A G T T G G G CTT C G TA G A A G C G A C G A A TC G T CGGGTACGTACT G C A A A C C T G A G T A C T T A C TT A T T G A G C CCTTACCGTGTG C G T T C T C C G C G C C CC A A G A C A A C C G C A CACACAACCGGT A G C G G A T T CG C T A C G C T A C T T G G C G C G GCAGGAGGGGTA C G T AGAC C G T A C T G G G C G G T A A A T G A G T CCCCGAGCACTCACTACGC G T A T A G C A T G C A G G A T A A A T T A C GT C C GATTACGAAATC G T C G T T A G A A C G C C A A G C GC G C A C A G G CGAACCGTCATA C G A G A C T G C C C A C GT T G T G C T T A C A T C AGTAGATGGTGA C T T G C C G A AG A A T G A C G T A G A G C G A T G GAAAACAGCAGA A G C CCTC G T T T G T C A G A A C G C G A G A T A C ACGCCGTCCACGCTACGTCCT T C A G T C A C G C G G G G C G A C G A A T TT A G G TGTAAGTATTGA C C C G C G T T T C A A T G C A G TG A G G A G G T A CAGTCCCCCT C T G G C T G G T G A G A GT A G G C G T T A A A C A CGGTTCGACGGG T T G G G G A A CA G A A A A T C T A G C G T G C T A ATCCCTCAGACT G C C AnA T C G C C T T C A A A A A T G C G C T G A A CCCAGGTCCCoit GtAC T C A T T C G G G C C C T G T G C T A G C A T A C AAAanGAeAAGACGTGA G T A T G C T A G A T A C A T T T C T C G C TiACCCAGATATTCCGACAATCCCGCTATT G A T C G G G G C C A G C C G C G A CCTTAGATAGCGTAAG T G A T C T A A T T T C G C CATCCTT C G A C G T T T C G G T Gr T T T G A G A T C T C C C C CGGCTGGACC A C A C C A G C Ao3 G C A A A G A C G G T T C C G A G A CGAGAAAAAC C C T C A'- G T C T T A T T G C T C A T G C T C C A A G ACGTCCGCAT G5 GAT G T A T C A A A C G CG G'C G C A G C C A A G T T A G T TGTCGGACG T A C T C G T G T A T T A G T C C A C C C A G TnieGcTTGTCCATGAGCGGAAGCG T G A A C C C T G T A C C G T C T G T GCTGAATTGTC C C C A G T G G G G C T T T C TnAeATuGTGGTCTAGATGCCAACAGTAGATACCGTACGCC T T G G G G A C T C C GGCCCGTTGCT C A T A C G A CqGCCGCTCCTAGTGTCGTCAAGACGTACAATCTTTCTCGGTAGGAGGGCGCG G G C ATGTGGGTAACeAAT T C C G A C G G T C G T C G G T A A A G T C T A G AAAS ATTCGTATGGGGTAATGGGCCTAACCCGAACTCCCCCATGTGGGATCCGGGGAGTCCezislato)p53Tb(33OQNE6SDI31PeMV LCm_aGA7NR R11A C T G C G C G C C A C A A G C A C G C C T C G C T A G A TAACCGTGCTGAATAAGTCCGA A T T A A C G G G G G C G C G AT A T G T T A G G G TGTGGTTGATCGTC C G G C G C A C T GT G T A T A G G A A C A T A A G CGGTCTAGTCAGAC G C C GATA T A A A A G A C G T C T A G T G G C G G GGGAACGGCGATTGTAGGGAGGT T C T C A A G G T C A A A T G C C C G T AC T G T A ACAGGCCCGGGAGG T G A C C C C A T G G T G C AC C G G G C A G A A A ATCTAGAACTGCGA T G G G C C G C CG C G A G C A G C G G G C C G C T TTTAGGGGGGGC G C G CG C T G A G G T A G A TG C T G CTA T G T C A C G T T C T A T A AGTGAAAAAGGAAGT C G G T G C G C C T C G C C C G G C T CT T G G A C GGTTCTCGTCCGAC G T A A G T T A C T A C G CG C C G G G A G G T C G AGATCGAACAAAGG C C G C G G A CT T T A A A C G G G C A G G C T G T CGACGGATCGCGCC C CC T C C G C C G G G G T A AG C GG G AG C G G C C G A G G C C C AT A CGGACATCGGTTCG G C A T G C T G C C T C G C C C T CT G G G G C T A GACTTCTCTTGA C C G G C A G C C G C G CT T A A T G C G A T G T C GGTAACATCTCGAA C T C A G C CT T C G T G C A C C C G A T C C G T C CGGCGGGCTTTCGC AA C C A T C G A C G G A G T AA GG C CC A C C T C G G T C C A C AA G CGGTCCCACC A A C G G G A T C A G C T C A C C A G C TC A T G A T TCCACCTCCTCG T A C C G A T T C G G G G A C GC G G G C T C T C C T TTCCTAGAGCGA G T C C C G C C T G GC A T T C C C G G G T T C C A G ACGACCGCCAGG G A C C G TA G T A T G T T T A A T C T G A G G C T C CCCGTGGCAT G CA G C G T A G T A C A G T GG C CA AT C G A C T T C G G G A G C CA CCTGGAGTGATC A G G A C A A C T C C T C G G C T G G C CT G G G A G AGGTTTGGTCAG G G T T A T A C T C G C G C A GT A A A C A A A T A A GTCGGACGGCTC T C C T C G G G T C TC A C A T C G A C A A G T G A A AAGCTATCGTAC C C C C C AG A T T C G T C C C A A C A T C A G C T C GGGCGGGCGTAC CG C C G T G C G C C C C G T CA AG A CG C C C C G C C G T T G A AT T CGGCCGACCA A C T C C T T G C G T G G C C G T C T G AC C C G T G TGAAACCACTTT T C T A T C T T T G G C C G G AT A A G A G C C T C G CCTAAACGATGC T T C C G C G C T C CA A C C G G C A T G G A G C C T TTTCGATCAGCA C A C C T AA C C G T T C C G T C T A G C T T C T C C GCCCGCCAGA T CA C C A C T C G G C G G C AT C AA AG T A A C T T C C C A G G G CA ACGGACATACAG A T A A G A A C T G T A C C G A G G G G GA T G G A A AGTCCACCTCTT C T T C G C C C G A G C G A T TC T A G C G C C C C G CCGAATTACT T T C G G C G C C C C CT G C A G G G C G C A T G G A ACGACTAGACCC G C T G G C GG A A C A A G T G C G T G G T T T C C G GCCTTAGGAGGC C Ani G C C C C A A C G T T G AG T Go T A C C G C A C C A C C G A C Tt GtGTTAAA C A C A G T C C C C A T T G T C C G G A C G T A CanTeTC ACCGAAGCAC G T A T A C A C C G G G G C T A A T T C TiCACGGTACGGCAGAGCCCTAACCTACCTCCTGGG G G C A T G C G G G T G A C G C TGGGTTTCCGACGTAA C A C G C C A C G G A C TTATTTG C A C G C C A G A C Cr A C T T A G A T C G A T G C C T TGACTCTGCC G A C G A T Go3 G T C T G G T C A G A A T C C T C C C G CCCCCGGTCT A C T'- T C T G G G T T C T G C T C G G T C T A C C G G GCGGGCCTA'5 CAT T T A T C T A G G A C A G A C A A A C C A C T A C G CTCCTGCGTAA C T T A G C A G A G T C C A G A A G C G G C GnieAcCGAAGACACAATGTCATTAGC A G C T G A C C A A C C A C C G A G GGCCGGTCTCG A A T T C T G T C T T A G A AnGeGTuACCCAAGAAAAAAGGATCGTCCAGGACTGCGCT C T A C C A A T G C G GTAGCGCCCGC T G G C C C G TqACATCCCCTTCGTGGACTTCTAGAGATACACGGGTCAGCGGACTATCGCCA C G G AAGAGTAAACAeTAC T G G T C A A G C G G G G T T G G T C C C G G G G GGTS CTGGAAAGGCCTCACGGGAGAAGACGAAGCAACTGAACGGGGCTGGCGGGGAACTAGezislato)p58Tb(24OQNE7SDI31PeMV LCm_aGA8NR R11A G G T G A C A G A T C G A G A A C C G G T A T C C G G C A T AAAGTCGACGGTCCAGAGTT G G T T A A A G A T T A A C A G T A TG A C G T G G C A GCGGAGACCATA T T T A T G C T T C G G A GT G C G G A T A C T T A G C CCCGAAGGAGTC T C T T G G G G AC G A T G A G A G T C C A T C C A G A ACTGTTTACGGA T G G TCCA C G G A G A G T T A A C T G G G G C C T T C CACTAAATGGGTACCAGAACA T G T A C G A T C A A T T C G T A C T A G A T AC C C C GCTTTGTTCCAG C G G A A T A A G A G T A C C G G G CG C A T T A C C T GTTTAAGTCTAA C T G T G T C T A A G A T AT C G C C T T C T T C T A G AATCCTTTGCTA T C C G T A C G GT T T C A A C G C C C A A T A C A A C GCCCTCATTGAA G T T ACCT C G A A T A C T A A A C G T A C C A C C T G ACAGAGTGGGGTCTCCACGTG C A T T T G A G A T C A C A T T A T T C C C A TG T C C CAGCGGATCAGA T G A G T A T T G T G A G A A T A A TT T A A T T A C C TGCAGGAAGAAG G G C A C T A T G C A A A GC T C A A A C G G C A A C G GTCACTCGGTTT G C A T A C C G GA T G G G G T G A T T C A G G C G A G GTCTCGTGGAGC T T T ACGG G G G G C G G C T A T A A T T C G G G C C G AACGTTAACAAGACACACTAA C C G G G C T C C G A A C A T G C T A A G A A GA T T C GCCGACGGAAGT G C T A A T G C A T T G T A A T G A AA C C T T G C T C TAGTGGTGTCAC G A C G C C T T C G T G A AA G G A C C C C C T G A C C AAATTCTTTTCC T A T A T A T T AC A A T C G C G T C T G G A C G T A T TTTTATTTTCAG A G A ATGA C C C A G A C A G G T C T G G G A T C C A C GGTAGAACAGTTGGAGTTTTC T T C C A T A A C A A A C G C G G T T C G T G CA A A T CCCCGCGTCACG T T G C C A G C A T A T A G G T G G GT G G C T C C A C GGTACGTTCACG A T T C A C T C A T A G G GA A T G A G T A C T G A C C AGAGGTCACACA A C A C A A G T AA C G T T A C C C T T G G G G A T C G TGACAGACATTC A A T AACG C G T C C G C C C T A G T G A T T C G C T A AACAAAGACCCAGGCAGACTA G G A A T G G G C C C T G T G T T G C A T T A TC A C C ACGGGGATGATA A G G G A A G A C A G T T A A T T G TG A G C A G T A A GTTTCTCCCTGC G A C T G T T T G A A C A CA T A G G A C A A G C G C C ATTAAAATACAA T A A T C G C A CA A G G G G C C G T C T C A C C A G G TCCCTCTAGTTA T G A CAGA G G G G T G C C T C G G T A C A G T T C C T CGAGTGGCACGTTATTGCGTA C G C A T C G T G C C C T T C T C A G A C T A AG T T G AAGGTCACTGGT C A C G A C C C G G C A T G G A T A GT G T T C G A C C TGATTCGTCTCG G C G A G C G T T T G G T TT T A G G A C T C C C G G C GGGAAGTTGAGA G T G G G A A A TT G A G A G T C C A T A A T G A A A G AAATTATAAAAA C A C AACG G T G A C T C A T G A A T C A A T C C T G G CCTTGTCGACGAGACTCGTTG C A C G C T C G A C T C T A C A A A A A A T C AnA C C G GTCCGGATTA C A C G C G A T C A T G T C C T A A A Aoit ACGGAGGTCGCCTCGTAGGTTACTAAGCGT C T T G A C C A T C T C C C C GACCCTACA T T A T A T A A T T A A TatnGeATGGACTGAGTAACTAGCAAATAGACTTCTGGAACTGATACAC C A T A G T A G GTTCCTATGGT A A G G CiCTAGTCACCTCCGACGTTGGCAAACAG T G A T A T C C C AATCTCTAAATGTrG T T T A T T G A C C C C C A A CoT3 AATTACCG T C A G A G G A A G C C C C C A T C A A T C G T T'- A C T GGGTGCGCCT C G G G T T C T A G G C T A C C T G A C G5 C G A T A T A TCCCTGTT T C A G C G A G C A C T C A A A G A' TiCGGGAGGGACGGATCGAGGTGCTCTTTTGAAGA T T C T G C C T C C G C A TTAGCCAACGA A G T A A A C A C CneA T C A G T C C C A A G G T C T G G TGGCATCCCC T G C C C AcGnATTACTTAATGCGGGCGGCGTGAAGAAATCTACTGGATCCGGACATCCTTGTACCCA T GACTACAAeTuTCqCAAGATACT A A A A A G C G C C A A A A A A C A G A T T T G GCCGCAGTCTC G T C G C C C A A T A G A T G C C A C G AeTAGTTTCTGGCGCCGATCGAGGTTTCTA C A T T A C A T T G A T C T T G GCCCCAGGG C A T C G A A G T A A G A AS A C A C T C G A G G A C T G GAATAGGTTACTACGACTAAAGTCAAAATGAezislato)pTb(OQNESDIemaNC C G A A G G A G C G G C C T A T A G G C A T T C C G AAAAGCGTTATAAAGAGGATTA T C A C C C C G C T A C G TC A G T A T G A T C TCTCAGTATCGTGA T G G C C T G AC A G C A C A G G T A C G G T T GTGCGACGCCAAAC T CC C T A G G G G T T C GG G CT GT G C C T G A C T T C T C GA GTTAGATACGAAGA T T A A G G C C T G C C T T C A AA T A T G A G GGGACCAGGAGTGT C T G T C T C T C T GT A T C T G G G G C T G G TGGCGCTAATCTGT T C G T AG C C A C A G A A G C G G T T A A T T ACGCGCCAATTCT A G C C G G G C G T G A C TGG A A C TG G G C C A A G A G GC C C A AGGTATGAGTACCC G T G A G T G G C C A G G GA G C C T A G T A T GGAGAACAGGTACG A T T T C A G AC G C A T A G T G T G G G G A C CAGAGACCCCCTAC A CA G T C T G A C T A T G GC G TC T AA C C T G A A A C C T A GT C ATACCGTGGGGAGC T T A A G G A G G C A G C C T AC C T G G C A C TGACCTGAGCCGTA T T A G A G A T G AA G G A A A C A T C T T G C CTAGAAGTGACA C C C C AGAA T A A C C T A T A G A C C A A T G ACAGTGTCTCTATGCCCTCCAAA A C C C C G T T G A T T G T T T C T C T AG A A G ACTCGAGCGCGG G G C T C T G T C C C A G C C CT G C T A A G T T AACTTAGGGATC G T C T C C C T T A GA A A G A G G T A C C G T T CCAGATGCTTCA T A C C C GT A C T A A A A G T A G C C A A G A C GTTCGCCTTGAG GT C A G A G A G A C C T G CA TG T CT A T T A T C G T C G C CG T GACAAAACGT G T T A T C A A G A C T A G C G A T GC G G G A C ATGTATTGGGAT G A G G C G T G A C T G C GC A T T A G G A A G T TCCTACTGAACT T A T A T A A T GG G G T A G T G G G A A C C C C TGTTGCACCTAC C C C CGTG G A C T C T T G G A G C C A A C A T C CGCCTTCTTTCTACTGGATCG C C G A A C G C C A G A C T T T C C C A GC T C G TTGCGAGGGGCG C G G C G A A A C A T A C T C AC G G A G A G G T CTGCGAATGTAA G C A G A A C A A A TG G G C T C A A C A T T C T TAATCGACCT G C A C C C TA A G G C G A C A C T C G C G G G C CTATATTCTCCG G AC G T G T G G C G C A G TC T TT TT A G A T A T C C C T T T CG TCGAGCAAGTAG G A C A A A C T A A G C G T C T G A GA C A G G G AGTGAGAGTG C T T T G C C T C A C A C T AC A G A A T A A G T GGTGATGCCTAA G T A G G C A T C CT C T T A T G G G T T A T A G GAGAGGTCCACG A T C C CG T A C C T A G T T C G A A T T G G T G GTCGGTCGCCGTA A A C G G A T C C T G C CCG G AT T A T C A T A G G T T TA A AAAAGGGAACGG A G C C T T C C G T G G G T T C C Tni A C A G A A C GTCGTTCCGT T A A T T T A T G T C A C Tot A G A T C A A A C G G ATTGATTATG A A C G C T G C G GtT G C T A G A A C G G C T G C CAGGGCTG T C T G A T AanCeGG A C A A C G T G G A G G T A T A GGGCCCCC T A A C TiTCGTAACCGGTTGGTCTGAGGGATGTTGTCGCGCCTAACAGACCCGCTTCCG C CGGTCGTTrG G A T G A A T A G C A T G A T A A G T G G T T A G T CoTTAGAAA T A T T C G T G T G A T A A G G G C C C C G T G'3- GTTCAATGTACACAA T C G G T A A G A G A G A G G G A T T T TGTTGAC A T C C G A A G A G A C A T T A C C T'5GTGGCAAAGAATTTGTGCTACTTCC G C A G T C T A C T T C T T G TCCTTTGAA A T C G A C C G G T G T AnieGcTAGTCACCCATTTACGTAGTTACTCCAGAGGATTAG G T T C A T T T T CCTCAAACT C C A C C C AnTeTGATCGGTCAAATGGGGAGAAAAGAAGAATTAATAACGGGAGCAA C C G C TCCGCGCTT T TuCqAT T A A G C T A G T T C T G G T G G G T T G T TGATTCGeGTGTA G C T G T T A A T A G A G G G A T A C G T C C A TTCCTCG T G G C C G T G T G A A A T C C T C C C C G TS A A C GTCGAGGTGTAGATCAAAGTCTTAAGACCCAGGCGTCTCCGCGAGTCATezislato)p 1Tb(35OQNESD8I31PeMV Cma L _ 9NGRAR11A G C T C G A T C G A G T G C G A C C G A C T C T C A T G C GGGAGCGCTTGCTCCGGGAT A G A C T G C G A G C T G C C A C TA T T T G A A A A GGAGATGAATCG T C T C G C C T T G A C TA C G A A C G C C C A C T G GAAGTCGAAGAGAG A C T T G A AG T T G A C T A T G C T C G T C C T A G AGTGTTCAGAGA A TT T G A G G G T G A A C T GA C CA C AC C A C A T A C C A A A C T TC C TGTGATAACTTC A T C G G C C G C C C C T G C A G G A AC G G C G A G GACCACTGTAGATC T G C C T G C T A G A G G CC A T C T G G G C G C T T GCCCAGTCCCAC G G T C G G A G CG A G T C G T C C A C G T T T C G G AGAATAGACCCC G C G GTGA G T A A T C T A T G A A T A T G C G A G G TACACACTCAGTGAAGAACACCT G G G C T G T C A C C C G G G G C T G G C AT C G G G TACGAGGGTTAG A A G T G A C A G A A C C T T G CT T T T A C G A G G CGTGTTGTGTGTCC C C G C C C C T C T GC G G A A C G C A T C C A T T G GACGTCGAGGAG T A T A C GC G G C A G G C A C T T T G A C A C G A A CTCCTAGTGACTCGC G A C C A T T C T T C C C C AAT C G TG G T G C C G C G A C T CT A G ACTCTGGTCCAC A T A G T G A C C A A G C G A C A T TT A A A C A T C GGGGGGAGAAGC T C C C C T G C C A A A G GC C G C T C T A A A A G T AGGCATCAGTCTCC T T G T A A G AC C G A T T C T C C C A C G A G T G G TACTCTCTGCCC C A AT C T G C A C C C C C A GA A C AC TA T T A G G T A C T G T C A C AT CGGAGGTCCTGC G G G A C G T T A A T C T T C G C T C C TC T G G C T TCGTATTAGCGCTA G C T C C G C T T T G C C C AT A G T T G T G A C A A AGAATCTCCTGA T G T T C G T A G CT A T A C T C G A C G G T G C T G ACTCGTGGGCCCCG C T A GAAG C T G C C G C C G G C T T C A G T T T T T CGTCACTAAGGTTCGGGGGGTAG T A G T G A G A T A T G C T A C T C C T A TC C A G A CTGGTGTGGTCG G T T G A C T A C G C T C T G C CC C A G T C T T C G GGGGGGAGATCCGC G T T A C C C T T A GC C T A T C A A A G G G A G A C AACTACTCGACA C G T A A GG T G G C G G C C C A A A T C C C C T A T GCGCCTCGAAGATGT C G G T G G C T A A G G G A TCC C G GA C T T C A G A T A G T TT A A ATAACGTCCCCG G C G T C A A C C G T A A C C A A C CC C G G T C C T GACGTCCTGGAC C G C G A C G C C G A T C GC C G A T T C G T T C C C GTGGGTCGAGTCCC A T G G A T T AT G G C C C C T C C A C G A C G T C C CTCCAGCGGATG T C CT G G A G C T C C C C C AG T T AC TG A A T T C C C C G A T A A T TC TACCGTCACCTA G C C T C T C A G T C C C A C C C C T T TC T C G G C GACACCAGACCGTG T C A C G A G A G C C C G C CC C A G A G T C C C C T TTGAGTTGTCGT G T G T C C G A G GA G C G C A C T C A G A T T T A T TCAGACTAACCT T G G C CC A C T G G T A C G A A C G A C C C T G G A TAGACTAGGTCAni C C G C G A G G C T T A G T AGot G A CC T G A A G C G T T A T C AtA C CGTGTAGC A G C A A G C C C A T G A C A A C A A G A CanGeAA T A A CGTGATCTCGAG A A C C C G A C C G G T C C T G GiCACGCTCCGTTGTGTGCTTCGTCCGGGTAAGGGGTTTGATTCCGAC C G T C G A G C A C C A TACAAGCGCACCGGTTCCT G G T A T G A CCTGACTCC A C T C Gr C A T T T C G C G T A A C A C T G G C T G T CGGAGCGAAC Go'3 T A C C A G A C G C G T T T G T T T C T G C C T T A ATCGTTC- ATCCT G G A C T C C G A T G T C C G A C G G T C G C A G C T'5GTCCCCAACATTC C C C G A G C T T C G G T C A C C C T A C A T TTCAACTGTCA C A C G T A G T T G G T G C G C A C T CnieTcAAACCCTATCAGGTCGCATTCGGAGC T C G G C G T A G G A T T G C G GATTGTTCTCT C G T A C A C C C G T A TnAeTCuACTCGAGGAAGACCACCGATACTCGATACCCGACAGATA C G T T C G G C A TTCCTGACCTC T T T T G TqACTCCGATCGGGATCCGGAAGGAGGATGTCCGGCCCCACACAATACCAGCTGCG T T ACTCTTCTCAeCCA T C G A C C T G T A G G C G T C G C G T C A G T T G A TS GTCCCCCGTAACTGTCCAACACGTCTGAACCACTCAAGCAGCGGTGTGTCGTAGTCATCezislato)p23Tb(12OQNE9SDI31PeMV LCm_aGA0NR R21C G C C A T G T C T C A G A C G G C G G C A G G A G T T C CGGACCAAACGTTGACTCCCCC T C G G T T A G T C T A A T A CC G C G C A C C C T AACTGCCGGAGTTC G A C G G A A T G TC A C A C C T C C A A C A C A G TGTTTAGGTGATAC T C A TACA C T C A G C C A G C C C C C A C C A C T CTGTTTGTGTCCGGTCGCCGCTG G G A A A C T T G T G T C G T C A C G G TC A C C A CACGAAGCCCCATT C G T C A C G T C G C G G T CC G T T T C C G C C C GCCCCAACCGTCCC G G C A C G G T TG T T G C T C G C C T T A C A C C TCTGGTAGAAAT C A T AT T T T C G C C T G T GT A T G CCG C A G G C G G T C C C A C G CGTAGGCTGTAACAT T G A T A G T A G C T G T G C A T C G TA G T T G C CCAAGAGGATTCCT A C T T C T G A C A C G A CT G C C G G C A A T C A CCCCGCGTGGGG T A G C G C G C CA G G C G A A A C C C G T T G A T TACGGGATCCAATC A G CA A G A A C G C T T C G TC C T CC AC G G G G C G A A G G T T T TA GTCCGCACGAACCC G C A G C T T G T A A C G T G A G A CG A A G C G T ATGAGCTTTAAG C G G A A C G G A A C G C TA A C G C A C T T A T G CTCGGGTGGCCATG G T C A T A C CA T C A G G C A A C T G T C G C G C AAGGAAACTCAGGT C AG C C A G T T G A T A G C AA G GT C CC C T G C G G T C T A C G TC T AATATCTACTTT C G C T C T G G A A G A C T A A G T CC T C A C T A CACCCAGCCCCCCC G G A A T C C T G A T C GG T C C C T G T T A T C G CGAGGGGTACGCGG T C A C A G AG A C G C G G A A T C G A T C T G T T AGACGTGCCTGGAG GT C C G A T G A T A G A G TA TG A GA C T A A C A G G G T C A CA G CGGCAGCCCAACTG T C T C T G G C C C G T G G C G C GC G T A G C G C TTCCAGGCTTATCG G C T G G C T A A T T AA A C C A C G C T C G T G C CGTCGGCGAGGTTA G G G T T CG G A G G G G C C T T C A A C G G A C A CTCGAGAGCAGGTGG C C G T T T C G T C C A G C TAG C C G TT C A G T G A C G A A AA A C G TAGATCATAAACCT A C G A A C A G A G C A T T T TA A T G C T A G C C TGATCCCAGCGGGC G G A A G T A C G GG A C A T A G A T C A A C A A G GCAGGTCGACCT C G A T AAGG T T G T A G T C T C C C C A G T A C C TCTGTTGTCTCCCTTGCCGCAATTC T T C A C C A G C G G C G C T A C G C A GT G C A A ACTATTGCCGATAC C C G A T G G A C C A G A C AT T C C C G G A A C C CTGCTCTTAAC A T A C T A A G A G AA A T T T C A A A A C A A C C C TGGCAATCCGAA G A A A T CC G A A C C T G T G T G G T G T T G A A C CCAGAGTGATCA GG A C C C C A A C A G G T T GC AG T GT T G G G A T G G C G G A AA A CATAGCAGTA T G A G C T G C C T G A A C A T A T T C AG C C A A G TCTCATCACTCC A A G G G A C C T A G G G C G Gni A T C C T A C C C T C TTACCCATTG G C G G G A A G T T T Got A G A C T G T C G T T T T A C TGAGCATAGA A T C T G A A AtG T C C C T T A G C C A C C C A G A C ACCATGGC A T G C GanG A T T T C G A T T C T T G A C A G G C G A GCCAGTGTAC GeAiTG G T T T A A A T A T C T G A G G G C G C G G G C TAGACTGGATCCA T C G A T G T C C A T G G A A A C G A G T C T Ar A G T ACAAGCCT T A T T C T A T T G A A G T T C A C G C Go G G A C T A TCTAGACTTG C C G C A A C A A C C C C G G T A'3- GGGTAGTTCCCAAAAAACCCGGTATGTCTATTTG G C A A C A G G A C G G GTTTGAAGG T G C T T C G G T A'5TTTTAGTCCCCCAGAACCCATAGATACCTTATGACGGGTATAAAA A C T G C G AAGAGTTCCCA G T AnieGcAT G C A C T T C A G T T A G C C T C T T A C G TCATGCCGTnCATGTC G A C C A A A C G C G T G G C C A C A G C A A G AeCuTCqAGCCTTTCCTCAT C T A C C A C T A G T G G G C A C C G C T AATATCAGCCC T T C A C A A T A T T G C C T G T AeGATGTGCTGGCTACCCGCGCTATGAACCTAACCGCAACCATGC C G A G A C C T G A T A C AATAAGGGATGGGGGG T C C T T C C A G GAACAGTAA C T A C C T TS C A G C T T C A T A G C A T A A G G G A AACACGGCGAATATCATezislato)p4275Tb(1102OQNESD0I41141PeMV P Vma LCG_MA1 LCG_A2NR R21 R R21T A A T C G C A G G A A G C T C CCGCTCCCTTCA G A A A C A T CC G C T C ACCGACCG G C A A GC G C G A C A A CTTATGGTAT TT T T G G A CA TCG G C C A G T ACGCGAGAT C C G G A C C A T TC C C ACGCTAGA G A G A C T CG T C A A C GGTACTTTAC T T TG C C G C C A G G T GTGCTTTAA T T T T G G ACC TA T G T C T CG TTCTCCAG T T A T T G C T GA G C C CGTCAAGGCT A G G T AG T G T T G G G ACCCGTTA T GGTC C G A C G G C C T CCAACACCTCCCT C A G A C A T C G C GT C TAACCCCTGG C A T T A C GC T G T T G TCCGAACA A G G GC C T C G T T C T CTTGATGA AT A G A T C AT CCT C C T T T T TCCATACCTCC C T T T G G C C GT C C A TCGGAAGT T G A G T AG C T C C T C AACTTCAC C C AG T A C A T C C C C CCCGAATAT A A T G A G AAA G CC A C G G T TA T CCCACGTG G T T A A A G AG A C G T TTCGGCTT G A C G CG C A T G C G G CAAACAAT G GA T C C T CT A GCC A T G A G G T GGTATAGTC G C G C G A G C G TA C C AGTGTCGGTT C A G T A CA C C T C G C ACTTTCTT T T GGTC C C G A C G A A TACCGACGGCGTTCA T C A A C A T C A G CT T TTCACCTA C T G C C G G TC C T G C GCCGGACA C C G G CG T C A C A G A CTGAAGAACT GG A C G A G AC ATC C C T G G C ATGACCGGC T A A C A A T G T AC A C TACCTGTG G A A C A C GG A G T C C CAGAGTGCCA A A AT T T C T C G A G A CTCTCCCGC T C C C G A GAnCG G G A T G Aoit TCGATCCG G G A A G G A C T A ATTCTTT C T G T A T G C TatnGeAGGTATCTGATGCGG G C T G T G GGTTTGC G G T A TiTCTCTCCCCCCCACTCAGAGTTTA A C ACTCAGG GroC C G T G T G A A C C C CTAGG'3 G- AC C A T T G C G C T A T C A5 CC T A C G T G A T T C T C A T' ACCCTC A A G G A G G G C C A CiC C ATCG T T G C G T G G C C TneTcTA A TGGA C G T G C G G C T TnCGTCGCTGCACT A G T A T T G T CTACCGT T T C A A T GeTuAAqACAATCCGCCACACAGC T T T C C TGCGG A G C C TeGCCTACGTACCAGCTCGTAGCGAGCTGTTGG T T T TCTGGGGACA G AAA T CS C C A A C A C A G C G G CAGCCATezislato)pTb(OQNESDIsriapeesam ba=Npb

[0062] In some embodiments, a vector provided herein further comprises a promoter. In some embodiments, the promoter is a minimal promoter. In some embodiments, a minimal promoter comprises one or more short sequences capable of promoting transcription. In some embodiments, a promoter comprises an RNA-polymerase II binding site, a TATA box, a TF2B recognition element (BRE), a motif 10 element (MTE), or a downstream promoter element (DPE). A TATA transcriptional regulatory activation site is described in e.g., François et al., (2005) J. Virol.79(17):11082–11094.

[0063] In some embodiments, the promoter is a human beta-globin minimal promoter.

[0064] In some embodiments, a promoter is recognized by RNA polymerase II. In some embodiments, a promoter is recognized by RNA polymerase III. In some embodiments, a promoter is a human U6 (hU6) promoter, a mouse U6 promoter or a human H1 promoter.

[0065] In some embodiments, a promoter is a constitutive promoter. In some embodiments, a promoter is an inducible promoter. In some embodiments, a promoter is a tissue-specific promoter. In some embodiments, a promoter is the chicken beta- actin (CBA) promoter, the GUSB240 promoter, the GUSB379 promoter, the HSVTK promoter, the CMV promoter, the SV40 early promoter, the SV40 late promoter, the metallothionein promoter, the murine mammary tumor virus (MMTV) promoter, the Rous sarcoma virus (RSV) promoter, the polyhedrin promoter, the EF-1 alpha promoter, the dihydrofolate reductase (DHFR) promoter or the phosphoglycerol kinase (PGK) promoter.

[0066] In some embodiments, a vector provided herein comprises (a) the promoter; (b) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a reverse complementary sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; and (c) the heterologous nucleotide sequence.

[0067] In some embodiments, a vector provided herein comprises (a) the promoter; (b) the nucleotide sequence of any of SEQ ID NOs: 4-18; a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; a complementary nucleotide sequence of any of SEQ IDNOs: 4-18; a reverse complementary sequence of any of SEQ ID NOs: 4-18; or a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 4-18; and (c) the heterologous nucleotide sequence.

[0068] In some embodiments, a vector provided herein comprises (a) the promoter; (b) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse complementary sequence of any of SEQ ID NOs: 1-141 and 152; or a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152; and (c) the heterologous nucleotide sequence.

[0069] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) the promoter; (ii) (a) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (b) a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (c) a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (d) a reverse complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; and (iii) the heterologous nucleotide sequence.

[0070] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) the promoter; (ii) (a) the nucleotide sequence of any of SEQ ID NOs: 4-18; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 4-18; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 4-18; and (iii) the heterologous nucleotide sequence.

[0071] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) the promoter; (ii) (a) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longerhaving at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152; and (iii) the heterologous nucleotide sequence.

[0072] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) (a) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (b) a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (c) a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (d) a reverse complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; and (ii) the promoter; and (iii) the heterologous nucleotide sequence.

[0073] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) (a) the nucleotide sequence of any of SEQ ID NOs: 4-18; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 4-18; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 4-18; and (ii) the promoter; and (iii) the heterologous nucleotide sequence.

[0074] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) (a) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152; and (ii) the promoter; and (iii) the heterologous nucleotide sequence.

[0075] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) the promoter; (ii) the heterologous nucleotide sequence; and (iii) (a) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (b) a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (c) a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (d) a reverse complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or (e) a nucleotide sequence comprising oneor more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.

[0076] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) the promoter; (ii) the heterologous nucleotide sequence; and (iii) (a) the nucleotide sequence of any of SEQ ID NOs: 4-18; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 4-18; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 4-18.

[0077] In some embodiments, a vector provided herein comprises, in 5' to 3' order: (i) the promoter; (ii) the heterologous nucleotide sequence; and (iii) (a) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; or (e) a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152.

[0078] In some embodiments, a vector provided herein further comprises an enhancer.

[0079] In some embodiments, a vector provided herein further comprises or encodes a polyadenylation (polyA) signal sequence. As used herein, a “polyadenylation signal sequence” refers to a DNA sequence that when transcribed regulates the addition of a polyA tail to the mRNA transcript. In some embodiments, a polyA signal sequence is a SV40, human, bovine or rabbit polyA signal sequence. In some embodiments, a polyA signal sequence is a SV40 polyA signal sequence. In some embodiments, a polyA signal sequence is a β-globin polyA signal sequence. In some embodiments, a polyA signal sequence is a human growth hormone polyA signal sequence or a bovine growth hormone polyA signal sequence.

[0080] In some embodiments, a SV40 polyA signal sequence comprises or consists of AACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTC ACAAATAAAGCATTTTTTTCACTGC (SEQ ID NO: 142).

[0081] In some embodiments, a human growth hormone polyadenylation signal (bGHpA) sequence comprises or consists of Gggtggcatccctgtgacccctccccagtgcctctcctggccctggaagttgccactccagt gcccaccagccttgtcctaataaaattaagttgcatcattttgtctgactaggtgtccttctataatattatggggtggaggggggtggtatggagcaaggggcaagttgggaagacaacctgt agggcctgcggggtctattgggaaccaagctggagtgcagtggcacaatcttggctcactgc aatctccgcctcctgggttcaagcgattctcctgcctcagcctcccgagttgttgggattcc aggcatgcatgaccaggctcagctaatttttgtttttttggtagagacggggtttcaccata ttggccaggctggtctccaactcctaatctcaggtgatctacccaccttggcctcccaaatt gctgggattacaggcgtgaaccactgctcccttccctgtcctt (SEQ ID NO: 143).

[0082] In some embodiments, a human β-globin polyadenylation signal (hBGpA) sequence comprises or consists of Gctcgctttcttgctgtccaatttctattaaaggttcctttgttccctaagtccaactacta aactgggggatattatgaagggccttgagcatctggattctgcctaataaaaaacatttatt ttcattgcaatgatgtatttaaattatttctgaatattttactaaaaagggaatgtgggagg tcagtgcatttaaaacataaagaaatgaagagctagttcaaaccttgggaaaatacactata tcttaaactccatgaaagaaggtgaggctgcaaacagctaatgcacattggcaacagcccct gatgcctatgccttattcatccctcagaaaaggattcaagtagaggcttgatttggaggtta aagttttgctatgctgtatttta (SEQ ID NO: 144).

[0083] In some embodiments, a vector provided herein further comprises or encodes a Kozak sequence (for example, a DNA sequence transcribed to an RNA Kozak sequence). In some embodiments, a vector comprises a Kozak sequence upstream of the transgene. In some embodiments, the Kozak sequence is encoded by GCCACC (SEQ ID NO: 145). In some embodiments, the Kozak sequence (e.g., RNA Kozak sequence) comprises or consists of ACCAUGG (SEQ ID NO: 146), GCCGCCACCAUGG (SEQ ID NO: 147), CCACCAUG (SEQ ID NO: 148) or CCACCAUGG (SEQ ID NO: 149).

[0084] In some embodiments, a vector provided herein further comprises or encodes a woodchuck hepatitis virus post-transcriptional element (WPRE). See, e.g., Wang and Verma, Proc. Natl. Acad. Sci., USA, 96: 3906-3910 (1999). In some embodiments, a vector comprises or encodes a hepatitis B virus posttranscriptional regulatory element (HBVPRE) and / or an RNA transport element (RTE). In some embodiments, the WPRE or HBVPRE sequence is any of the WPRE or HBVPRE sequences disclosed in US 6,136,597 or US 6,287,814. In some embodiments, a vector provided herein further comprises or encodes a WPRE3 or a wsl3 regulatory element.

[0085] In some embodiments, a WPRE3 comprises or is encoded by GATAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTAT GTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATT GCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTAGTTCTTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTG GGCACTGACAATTCCGTGGTGTT (SEQ ID NO: 150).

[0086] In some embodiments, a WPRE comprises or is encoded by AATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCC TTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGG CTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCC GTTGTCAGGCAACGTGGCGTGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGG CATTGCCACCACCTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGG CGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGAC AATTCCGTGGTGTTGTCGGGGAAATCATCGTCCTTTCCTTGGCTGCTCGCCTGTGTTGCCAC CTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCGGACCTTC CTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTCGCCCTCAGACG AGTCGGATCTCCCTTTGGGCCGCCTCCCCGC (SEQ ID NO: 151).

[0087] In some embodiments, a vector provided herein further comprises an artificial intron. In some embodiments, a vector provided herein further comprises a chimeric intron.

[0088] In some embodiments, a vector provided herein further encodes a 2A self- cleaving peptide.

[0089] In some embodiments, a vector provided herein further comprises or encodes an internal ribosome entry site (IRES). In some embodiments, an IRES is located on the 5′ end of the gene of interest and enables the translation of RNA in a cap- independent manner. The transcribed IRES may directly bind to a ribosomal subunit, such that the initiation codon of an mRNA is appropriately oriented in a ribosome to perform translation. The IRES sequence is usually located in the 5′ UTR of an mRNA (directly upstream of the initiation codon). An IRES functionally replaces the need for various protein factors that interact with the translation mechanism of eukaryotes.

[0090] Provided herein is a vector comprising (a) the promoter; (b) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3, or a reverse complementary sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; and (c) the heterologous nucleotide sequence; and comprising or encoding one or more of the following: an enhancer, a polyadenylation signal sequence, a Kozak sequence, a WPRE, a hepatitis B virus posttranscriptional regulatory element, a RTE, a WPRE3, a wsl3 regulatory element, an artificial intron, a chimeric intron, a 2A self-cleaving peptide, and an IRES.

[0091] Provided herein is a vector comprising (a) the promoter; (b) the nucleotide sequence of any of SEQ ID NOs: 4-18, or a reverse complementary sequence of any of SEQ ID NOs: 4-18; and (c) the heterologous nucleotide sequence; and comprising or encoding one or more of the following: an enhancer, a polyadenylation signal sequence, a Kozak sequence, a WPRE, a hepatitis B virus posttranscriptional regulatory element, a RTE, a WPRE3, a wsl3 regulatory element, an artificial intron, a chimeric intron, a 2A self-cleaving peptide, and an IRES.

[0092] Provided herein is a vector comprising (a) the promoter; (b) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152, or a reverse complementary sequence of any of SEQ ID NOs: 1-141 and 152; and (c) the heterologous nucleotide sequence; and comprising or encoding one or more of the following: an enhancer, a polyadenylation signal sequence, a Kozak sequence, a WPRE, a hepatitis B virus posttranscriptional regulatory element, a RTE, a WPRE3, a wsl3 regulatory element, an artificial intron, a chimeric intron, a 2A self-cleaving peptide, and an IRES.

[0093] In some embodiments, a vector provided herein further encodes nuclear localization signals (NLSs). In some embodiments, a NLS is a simian virus 40 (SV40) NLS. In some embodiments, a NLS is a nucleoplasmin NLS.

[0094] The genetic regulatory elements provided herein can be used to restrict a gene therapy intervention (e.g., gene replacement, gene modulation, gene editing, and / or modulation of cellular activity) to distinct neuronal populations in the CNS while preventing or reducing the effect of the gene therapy intervention in any other organs.

[0095] In some embodiments, the heterologous nucleotide sequence encodes a protein.

[0096] In some embodiments, the heterologous nucleotide sequence encodes a gene silencing nucleic acid. In some embodiments, the gene silencing nucleic acid is a short- hairpin RNA (shRNA). In some embodiments, the gene silencing nucleic acid is a short interfering RNA (siRNA).

[0097] In some embodiments, the heterologous nucleotide sequence encodes a CRISPR-associated protein. In some embodiments, the heterologous nucleotide sequence encodes a nuclease-deficient CRISPR-associated protein (also known as a catalytically inactive CRISPR nuclease, a dead Cas protein, or a dCas protein). In some embodiments, the heterologous nucleotide sequence encodes a CRISPR-associated protein and a guide RNA (gRNA).

[0098] In some embodiments, the heterologous nucleotide sequence encodes a transcription activator-like protein effector (TALE) protein.

[0099] In some embodiments, the vectors provided herein are plasmids or viral expression cassettes that comprise additional nucleic acid sequences. In some embodiments, the vectors provided herein may be used to generate recombinant virus particles to serve as viral vectors for gene delivery. In some embodiments, the vectors provided herein are formulated for use with via non-viral delivery systems. Further provided herein are plasmids comprising any of the vector nucleic acid sequences disclosed herein.

[0100] In some embodiments, a vector provided herein is a non-viral vector. In some embodiments, the vector is a plasmid vector. In some embodiments, the vector is a bacterial plasmid vector. In some embodiments, the vector is a yeast plasmid vector. In some embodiments, the vector is a bacterial artificial chromosome vector, a yeast plasmid vector, or a yeast mini-chromosome vector.

[0101] In some embodiments, a vector provided herein is a viral vector.

[0102] In some embodiments, the viral vector is an adenovirus vector. Adenovirus vectors and recombinant adenoviruses are described in, for example, U.S. Patent No. 10,781,427. In some embodiments, an adenovirus vector is a helper-dependent adenovirus vector that lacks all viral genes except the ψ packaging and inverted terminal repeat (ITR) sequences.

[0103] In some embodiments, the viral vector is an adeno-associated virus (AAV) vector.

[0104] In some embodiments, an AAV vector provided herein is self-complementary. In some embodiments, an AAV vector provided herein is single-stranded.

[0105] In some embodiments, an AAV vector provided herein comprises a first AAV ITR located upstream of the heterologous nucleotide sequence, promoter, and the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse complementary sequence of any of SEQ ID NOs: 1-141 and 152; or a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152; and a second AAV ITR located downstream of the heterologous nucleotide sequence, promoter, and the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse nucleotide sequence of any of SEQ ID NOs: 1- 141 and 152; a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse complementary sequence of any of SEQ ID NOs: 1-141 and 152; or anucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152. ITRs are sequences that mediate AAV proviral integration and packaging of AAV DNA into virions.

[0106] In some embodiments, an AAV vector provided herein comprises a first AAV ITR located upstream of the heterologous nucleotide sequence, promoter, and the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a reverse complementary sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; and a second AAV ITR located downstream of the heterologous nucleotide sequence, promoter, and the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; a reverse complementary sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.

[0107] Provided herein is an AAV vector comprising a 5' AAV inverted terminal repeat (ITR) and a 3' AAV ITR flanking: (i) a heterologous nucleotide sequence; (ii) a promoter; and (iii) (a) the nucleotide sequence of SEQ ID NO: 1; (b) a reverse nucleotide sequence of SEQ ID NO: 1; (c) a complementary nucleotide sequence of SEQ ID NO: 1; (d) a reverse complementary nucleotide sequence of SEQ ID NO: 1; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1.

[0108] Provided herein is an AAV vector comprising a 5' AAV inverted terminal repeat (ITR) and a 3' AAV ITR flanking: (i) a heterologous nucleotide sequence; (ii) a promoter; and (iii) (a) the nucleotide sequence of SEQ ID NO: 2; (b) a reverse nucleotide sequence of SEQ ID NO: 2; (c) a complementary nucleotide sequence of SEQ ID NO: 2; (d) a reverse complementary nucleotide sequence of SEQ ID NO: 2; or(e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 2.

[0109] In some embodiments, an AAV vector provided herein comprises a first AAV ITR located upstream of the heterologous nucleotide sequence, promoter, and the nucleotide sequence of any of SEQ ID NOs: 4-18; a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; a reverse complementary sequence of any of SEQ ID NOs: 4-18; or a nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 4-18; and a second AAV ITR located downstream of the heterologous nucleotide sequence, promoter, and the nucleotide sequence of any of SEQ ID NOs: 4-18; a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; a reverse complementa...

Claims

CLAIMS 1. A vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (b) a reverse nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (c) a complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; (d) a reverse complementary nucleotide sequence of any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO:

3.

2. A vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of any of SEQ ID NOs: 4-18; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 4-18; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 4-18; (d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 4-18; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 4-18.

3. A vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (b) a reverse nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; (c) a complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152;(d) a reverse complementary nucleotide sequence of any of SEQ ID NOs: 1-141 and 152; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NOs: 1-141 and 152.

4. The vector of any one of claims 1-3, wherein the vector further comprises a promoter.

5. The vector of claim 4, comprising, in 5' to 3' order: (i) the promoter; (ii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; and (iii) the heterologous nucleotide sequence.

6. The vector of claim 4, comprising, in 5' to 3' order: (i) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; (ii) the promoter; and (iii) the heterologous nucleotide sequence.

7. The vector of claim 4, comprising, in 5' to 3' order: (i) the promoter; (ii) the heterologous nucleotide sequence; and (iii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity.

8. The vector of any one of claims 1-7, wherein the vector is a non-viral vector.

9. The vector of claim 8, wherein the non-viral vector is a plasmid vector.

10. The vector of any one of claims 1-7, wherein the vector is a viral vector.

11. The vector of claim 10, wherein the viral vector is an adeno-associated virus (AAV) vector or an adenovirus vector.

12. The vector of claim 11, wherein the AAV vector comprises a 5' AAV inverted terminal repeat (ITR) and a 3' AAV ITR flanking: (i) the heterologous nucleotide sequence; (ii) a promoter; and (iii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity.

13. The vector of claim 12, comprising, in 5' to 3' order: (i) the 5' AAV ITR; (ii) the promoter; (iii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; (iv) the heterologous nucleotide sequence; and (v) the 3' AAV ITR.

14. The vector of claim 12, comprising, in 5' to 3' order: (i) the 5' AAV ITR; (ii) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; (iii) the promoter;(iv) the heterologous nucleotide sequence; and (v) the 3' AAV ITR.

15. The vector of claim 12, comprising, in 5' to 3' order: (i) the 5' AAV ITR; (ii) the promoter; (iii) the heterologous nucleotide sequence; (iv) the nucleotide sequence, the reverse nucleotide sequence, the complementary nucleotide sequence, the reverse complementary nucleotide sequence, or the nucleotide sequence comprising one or more regions of about 100 bp or longer having at least 85% or greater sequence identity; and (v) the 3' AAV ITR.

16. An AAV vector comprising a 5' AAV inverted terminal repeat (ITR) and a 3' AAV ITR flanking: (i) a heterologous nucleotide sequence; (ii) a promoter; and (iii) (a) the nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; (b) a reverse nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; (c) a complementary nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; (d) a reverse complementary nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to any of SEQ ID NO: 1 or SEQ ID NO:

2.

17. The vector of any one of claims 2-16, wherein the promoter comprises an RNA- polymerase II binding site, a TATA box, a TF2B recognition element (BRE), a motif 10 element (MTE), or a downstream promoter element (DPE).

18. The vector of any one of claims 2-16, wherein the promoter is a minimal promoter.

19. The vector of claim 18, wherein the minimal promoter is a human beta-globin minimal promoter.

20. The vector of any one of claims 1-19, wherein the vector further comprises an enhancer.

21. The vector of any one of claims 1-20, wherein the vector further comprises or encodes a polyadenylation signal sequence.

22. The vector of any one of claims 1-21, wherein the vector further comprises or encodes a Kozak sequence.

23. The vector of any one of claims 1-22, wherein the vector further comprises or encodes a woodchuck hepatitis virus post-transcriptional element (WPRE), a hepatitis B virus posttranscriptional regulatory element, an RNA transport element (RTE), a WPRE3, or a wsl3 regulatory element.

24. The vector of any one of claims 1-23, wherein the vector further comprises an artificial intron.

25. The vector of any one of claims 1-24, wherein the vector further encodes a 2A self-cleaving peptide.

26. The vector of any one of claims 1-25, wherein the vector further comprises or encodes an internal ribosome entry site (IRES).

27. The vector of any one of claims 1-26, wherein the heterologous nucleotide sequence encodes a protein.

28. The vector of any one of claims 1-26, wherein the heterologous nucleotide sequence encodes a gene silencing nucleic acid.

29. The vector of any one of claims 1-26, wherein the heterologous nucleotide sequence encodes a CRISPR-associated protein.

30. The vector of claim 29, wherein the heterologous nucleotide sequence further encodes a guide RNA (gRNA).

31. A viral particle comprising the vector of any one of claims 1-7 and 10-30.

32. The viral particle of claim 31, wherein the viral particle is a recombinant adenovirus particle.

33. The viral particle of claim 31, wherein the viral particle is a recombinant AAV (rAAV) particle.

34. The viral particle of claim 33, wherein the rAAV particle is a MyoAAV, MyoAAV 4A, MyoAAV 4B, MyoAAV 4C, MyoAAV 4D, MyoAAV 4E, MyoAAV 4D, MyoAAV 1A, MyoAAV 1B, MyoAAV 1C, MyoAAV 1E, MyoAAV 1F, MyoAAV 2A, MyoAAV 2B, MyoAAV 2C, MyoAAV 2D, MyoAAV 2E, MyoAAV 2F, MyoAAV 3A, MyoAAV 3B, MyoAAV 3C, MyoAAV 3D, MyoAAV 3E, MyoAAV 3F, AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10, AAV11, AAV12, AAV13, AAVrh.8, AAVrh.10, AAVrh32.33, AAVrh.74, AAVhu.68, avian AAV, bovine AAV, canine AAV, equine AAV, ovine AAV, snake AAV, bearded dragon AAV, AAV2i8, AAV2g9, AAV-LK03, AAV7m8, AAV Anc80, TM-AAV6, AAV-PHP.A, AAV-PHP.B, AAV-PHP.S, AAV-PHP.eB, AAV- CAP.B10, AAV2-r3.45, AAV2-LSS, AAV2PFG, AAV2-PPS, AAV2-TLH or AAV2- GMN serotype particle.

35. The viral particle of claim 33, wherein the rAAV particle is a MyoAAV, MyoAAV 4E, MyoAAV 4A, AAV9, or AAVrh.74 serotype particle.

36. A population of viral particles comprising a plurality of viral particles of any one of claims 31-35.

37. A pharmaceutical composition comprising the vector of any one of claims 1-30, the viral particle of any one of claims 31-35 or the population of claim 36, and a pharmaceutically acceptable carrier, vehicle or diluent.

38. A nanoparticle comprising the vector of any one of claims 1-9 and 17-30.

39. A cell comprising the vector of any one of claims 1-30 or the viral particle of any one of claims 31-35.

40. The cell of claim 39, wherein the cell is a mammalian cell or an insect cell.

41. A method of producing a rAAV particle, the method comprising: (i) culturing the cell of claim 39 or 40 under conditions allowing for packaging the rAAV particle; and (ii) harvesting the cultured host cell or culture medium for collection of the rAAV particle.

42. A method for selectively expressing the heterologous nucleotide sequence in cardiomyocytes in a subject in need thereof, the method comprising administering to the subject the vector of any one of claims 1-30, the viral particle of any one of claims 31-35, the population of claim 36, the pharmaceutical composition of claim 37, or the nanoparticle of claim 38.

43. A method for selectively expressing a heterologous nucleotide sequence in cardiomyocytes and skeletal muscle cells in a subject in need thereof, the method comprising administering to the subject a vector comprising: (i) a heterologous nucleotide sequence; and (ii) (a) the nucleotide sequence of SEQ ID NO: 152; (b) a reverse nucleotide sequence of SEQ ID NO: 152; (c) a complementary nucleotide sequence of SEQ ID NO: 152; (d) a reverse complementary nucleotide sequence of SEQ ID NO: 152; or (e) a nucleotide sequence comprising one or more regions of about 100 base pairs (bp) or longer having at least 85% or greater sequence identity to SEQ ID NO: 152; or a viral particle, population of viral particles, pharmaceutical composition, or nanoparticle comprising said vector.

44. The method of claim 42 or 43, wherein the vector, the viral particle, the population, the pharmaceutical composition, or the nanoparticle is administered to the subject intravenously.

45. The method of claim 42, wherein the vector, the viral particle, the population, the pharmaceutical composition, or the nanoparticle is administered to the subject via injection into cardiac muscle tissue.

46. The method of claim 43, wherein the vector, the viral particle, the population, the pharmaceutical composition, or the nanoparticle is administered to the subject via injection into skeletal muscle tissue.

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