Pharmaceutical composition for skin diseases, and method for searching novel use of medicine

WO2025095039A1PCT designated stage expired Publication Date: 2025-05-08TIR RES CONSULTING LLC
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Patent Information

Application Number
PCT/JP2024/038820
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-10-31
Filing Date
2024-10-31
Publication Date
2025-05-08

AI Technical Summary

Technical Problem

The prior art is difficult to effectively treat skin diseases caused by anticancer drugs, especially hand and foot syndrome (HFS), and the lack of an appropriate drug evaluation system makes it difficult for animal models to accurately evaluate drug responses for skin diseases in drug development.

Method used

A topical drug combination containing cappa opioid agonist and Chinese medicine ingredients was developed to prevent and treat HFS through protective effects on skin cells. In addition, a comparative transcriptome analysis method was used to analyze the impact of drugs on the gene expression of skin cells and find new drug uses.

Benefits of technology

This drug combination can effectively protect skin cells and relieve the symptoms of HFS. Through comparative transcriptome analysis methods, it was found that Capa opioid agonist and Chinese medicine ingredients have anti-inflammatory, promoting cell regeneration and inhibiting skin damage, providing a new method to treat skin diseases.

✦ Generated by Eureka AI based on patent content.

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Abstract

A comparative transcriptome analysis according to the present invention is a very useful method as a method for searching a novel use of an existing drug. As employing the comparative transcriptome analysis to use a protective action of keratinocytes as an indicator, it is found that κ-opioid agonists and Chinese herbal medicines can become therapeutic agents for skin disorders that are side effects of anticancer drugs.
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Citation Information

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